MCID: KLZ004
MIFTS: 20

Kala-Azar 1

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Kala-Azar 1

MalaCards integrated aliases for Kala-Azar 1:

Name: Kala-Azar 1 57
Leishmaniasis 59 73
Leishmaniasis, Visceral, Susceptibility to, 1 57
Kala-Azar , Susceptibility to, 1 13
Kala-Azar, Susceptibility to, 1 57
Leishmaniasis, Visceral 1 57
Kaza1 57

Characteristics:

Orphanet epidemiological data:

59
leishmaniasis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-5/10000 (Worldwide); Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

OMIM 57 608207
Orphanet 59 ORPHA507
MESH via Orphanet 45 D007896
ICD10 via Orphanet 34 B55.0 B55.1 B55.2 more
UMLS via Orphanet 74 C0023281

Summaries for Kala-Azar 1

MalaCards based summary : Kala-Azar 1, also known as leishmaniasis, is related to leishmaniasis and visceral leishmaniasis, and has symptoms including exanthema, fever and pruritus. An important gene associated with Kala-Azar 1 is KAZA1 (Kala-Azar (Visceral Leishmaniasis), Susceptibility To). Affiliated tissues include skin, and related phenotypes are arthralgia and abnormality of the oral cavity

Description from OMIM: 608207

Related Diseases for Kala-Azar 1

Diseases in the Kala-Azar 1 family:

Kala-Azar 2 Kala-Azar 3

Diseases related to Kala-Azar 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leishmaniasis 12.8
2 visceral leishmaniasis 11.1

Symptoms & Phenotypes for Kala-Azar 1

Clinical features from OMIM:

608207

Human phenotypes related to Kala-Azar 1:

59 (show all 25)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 59 Frequent (79-30%)
2 abnormality of the oral cavity 59 Very frequent (99-80%)
3 abnormality of the nose 59 Very frequent (99-80%)
4 splenomegaly 59 Very frequent (99-80%)
5 pancytopenia 59 Very frequent (99-80%)
6 abnormal bleeding 59 Very frequent (99-80%)
7 episodic fever 59 Very frequent (99-80%)
8 hepatomegaly 59 Very frequent (99-80%)
9 lymphadenopathy 59 Very frequent (99-80%)
10 abnormality of macrophages 59 Very frequent (99-80%)
11 abnormality of oral mucosa 59 Very frequent (99-80%)
12 night sweats 59 Very frequent (99-80%)
13 papule 59 Very frequent (99-80%)
14 skin plaque 59 Very frequent (99-80%)
15 skin ulcer 59 Very frequent (99-80%)
16 pallor 59 Frequent (79-30%)
17 weight loss 59 Frequent (79-30%)
18 anemia 59 Frequent (79-30%)
19 elevated hepatic transaminases 59 Frequent (79-30%)
20 hypoalbuminemia 59 Frequent (79-30%)
21 increased antibody level in blood 59 Frequent (79-30%)
22 thrombocytopenia 59 Occasional (29-5%)
23 leukopenia 59 Occasional (29-5%)
24 anorexia 59 Occasional (29-5%)
25 fatigue 59 Occasional (29-5%)

UMLS symptoms related to Kala-Azar 1:


exanthema, fever, pruritus

Drugs & Therapeutics for Kala-Azar 1

Search Clinical Trials , NIH Clinical Center for Kala-Azar 1

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Kala-Azar 1

Anatomical Context for Kala-Azar 1

MalaCards organs/tissues related to Kala-Azar 1:

41
Skin

Publications for Kala-Azar 1

Variations for Kala-Azar 1

Expression for Kala-Azar 1

Search GEO for disease gene expression data for Kala-Azar 1.

Pathways for Kala-Azar 1

GO Terms for Kala-Azar 1

Sources for Kala-Azar 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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