KAZA1
MCID: KLZ004
MIFTS: 28

Kala-Azar 1 (KAZA1)

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Kala-Azar 1

MalaCards integrated aliases for Kala-Azar 1:

Name: Kala-Azar 1 58
Kala-Azar, Susceptibility to, 1 58 13
Leishmaniasis 60 74
Leishmaniasis, Visceral, Susceptibility to, 1 58
Leishmaniasis, Visceral 1 58
Kaza1 58

Characteristics:

Orphanet epidemiological data:

60
leishmaniasis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-5/10000 (Worldwide); Age of onset: All ages;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

OMIM 58 608207
MESH via Orphanet 46 D007896
ICD10 via Orphanet 35 B55.0 B55.1 B55.2 more
UMLS via Orphanet 75 C0023281
Orphanet 60 ORPHA507
UMLS 74 C0023281

Summaries for Kala-Azar 1

MalaCards based summary : Kala-Azar 1, also known as kala-azar, susceptibility to, 1, is related to cutaneous leishmaniasis and visceral leishmaniasis, and has symptoms including fever, pruritus and exanthema. An important gene associated with Kala-Azar 1 is KAZA1 (Kala-Azar (Visceral Leishmaniasis), Susceptibility To). Affiliated tissues include skin, t cells and liver, and related phenotypes are splenomegaly and hepatomegaly

Description from OMIM: 608207

Related Diseases for Kala-Azar 1

Diseases in the Kala-Azar 1 family:

Kala-Azar 2 Kala-Azar 3

Diseases related to Kala-Azar 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 284)
# Related Disease Score Top Affiliating Genes
1 cutaneous leishmaniasis 12.9
2 visceral leishmaniasis 12.8
3 mucocutaneous leishmaniasis 12.7
4 leishmaniasis, tegumentary 12.3
5 leishmaniasis 11.3
6 kala-azar 2 11.2
7 kala-azar 3 11.2
8 chronic rhinitis 11.1
9 chagas disease 10.5
10 malaria 10.5
11 trypanosomiasis 10.5
12 arthritis 10.3
13 acquired immunodeficiency syndrome 10.3
14 hemophagocytic lymphohistiocytosis 10.3
15 human immunodeficiency virus infectious disease 10.3
16 rheumatoid arthritis 10.3
17 sleeping sickness 10.3
18 lupus erythematosus 10.3
19 hansen's disease 10.3
20 leprosy 3 10.3
21 systemic lupus erythematosus 10.2
22 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.2
23 hepatitis 10.2
24 pancytopenia 10.2
25 dermatitis 10.2
26 lymphoma 10.1
27 splenomegaly 10.1
28 leukemia 10.1
29 pulmonary tuberculosis 10.1
30 trypanosomiasis, human east-african 10.1
31 bacterial infectious disease 10.1
32 filariasis 10.1
33 glomerulonephritis 10.1
34 erysipeloid 10.1
35 squamous cell carcinoma 10.1
36 vaccinia 10.1
37 blood group, colton system 10.0
38 myeloma, multiple 10.0
39 human immunodeficiency virus type 1 10.0
40 autoimmune hepatitis 10.0
41 paronychia 10.0
42 schistosomiasis 10.0
43 sporotrichosis 10.0
44 lymphopenia 10.0
45 lepromatous leprosy 10.0
46 toxoplasmosis 10.0
47 basal cell carcinoma 1 9.9
48 psoriatic arthritis 9.9
49 acute liver failure 9.9
50 chronic granulomatous disease 9.9

Graphical network of the top 20 diseases related to Kala-Azar 1:



Diseases related to Kala-Azar 1

Symptoms & Phenotypes for Kala-Azar 1

Human phenotypes related to Kala-Azar 1:

60 (show all 25)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 splenomegaly 60 Very frequent (99-80%)
2 hepatomegaly 60 Very frequent (99-80%)
3 fatigue 60 Occasional (29-5%)
4 arthralgia 60 Frequent (79-30%)
5 anemia 60 Frequent (79-30%)
6 pancytopenia 60 Very frequent (99-80%)
7 pallor 60 Frequent (79-30%)
8 abnormal bleeding 60 Very frequent (99-80%)
9 weight loss 60 Frequent (79-30%)
10 elevated hepatic transaminase 60 Frequent (79-30%)
11 thrombocytopenia 60 Occasional (29-5%)
12 skin ulcer 60 Very frequent (99-80%)
13 anorexia 60 Occasional (29-5%)
14 episodic fever 60 Very frequent (99-80%)
15 papule 60 Very frequent (99-80%)
16 lymphadenopathy 60 Very frequent (99-80%)
17 abnormality of oral mucosa 60 Very frequent (99-80%)
18 increased antibody level in blood 60 Frequent (79-30%)
19 leukopenia 60 Occasional (29-5%)
20 abnormality of the oral cavity 60 Very frequent (99-80%)
21 skin plaque 60 Very frequent (99-80%)
22 rhinitis 60 Very frequent (99-80%)
23 hypoalbuminemia 60 Frequent (79-30%)
24 abnormality of macrophages 60 Very frequent (99-80%)
25 night sweats 60 Very frequent (99-80%)

Clinical features from OMIM:

608207

UMLS symptoms related to Kala-Azar 1:


fever, pruritus, exanthema

Drugs & Therapeutics for Kala-Azar 1

Search Clinical Trials , NIH Clinical Center for Kala-Azar 1

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Kala-Azar 1

Anatomical Context for Kala-Azar 1

MalaCards organs/tissues related to Kala-Azar 1:

42
Skin, T Cells, Liver, Kidney, Myeloid, Eye, Prostate

Publications for Kala-Azar 1

Variations for Kala-Azar 1

Expression for Kala-Azar 1

Search GEO for disease gene expression data for Kala-Azar 1.

Pathways for Kala-Azar 1

GO Terms for Kala-Azar 1

Sources for Kala-Azar 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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