KAZA1
MCID: KLZ004
MIFTS: 39

Kala-Azar 1 (KAZA1)

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Kala-Azar 1

MalaCards integrated aliases for Kala-Azar 1:

Name: Kala-Azar 1 58
Leishmaniasis 60 74
Leishmaniasis, Visceral, Susceptibility to, 1 58
Kala-Azar , Susceptibility to, 1 13
Kala-Azar, Susceptibility to, 1 58
Leishmaniasis, Visceral 1 58
Kaza1 58

Characteristics:

Orphanet epidemiological data:

60
leishmaniasis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-5/10000 (Worldwide); Age of onset: All ages;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

OMIM 58 608207
MESH via Orphanet 46 D007896
ICD10 via Orphanet 35 B55.0 B55.1 B55.2 more
UMLS via Orphanet 75 C0023281
Orphanet 60 ORPHA507
UMLS 74 C0023281

Summaries for Kala-Azar 1

MalaCards based summary : Kala-Azar 1, also known as leishmaniasis, is related to cutaneous leishmaniasis and visceral leishmaniasis, and has symptoms including fever, pruritus and exanthema. An important gene associated with Kala-Azar 1 is KAZA1 (Kala-Azar (Visceral Leishmaniasis), Susceptibility To). Affiliated tissues include testes, t cells and skin, and related phenotypes are splenomegaly and hepatomegaly

Description from OMIM: 608207

Related Diseases for Kala-Azar 1

Diseases in the Kala-Azar 1 family:

Kala-Azar 2 Kala-Azar 3

Diseases related to Kala-Azar 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 281)
# Related Disease Score Top Affiliating Genes
1 cutaneous leishmaniasis 12.9
2 visceral leishmaniasis 12.8
3 mucocutaneous leishmaniasis 12.7
4 leishmaniasis, tegumentary 12.3
5 leishmaniasis 11.3
6 kala-azar 2 11.2
7 kala-azar 3 11.2
8 chronic rhinitis 11.1
9 chagas disease 10.5
10 malaria 10.5
11 trypanosomiasis 10.4
12 arthritis 10.3
13 acquired immunodeficiency syndrome 10.3
14 hemophagocytic lymphohistiocytosis 10.3
15 human immunodeficiency virus infectious disease 10.3
16 rheumatoid arthritis 10.3
17 sleeping sickness 10.3
18 lupus erythematosus 10.2
19 hepatitis 10.2
20 systemic lupus erythematosus 10.2
21 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.2
22 pancytopenia 10.2
23 lymphoma 10.1
24 dermatitis 10.1
25 hansen's disease 10.1
26 splenomegaly 10.1
27 trypanosomiasis, human east-african 10.1
28 leprosy 3 10.1
29 leukemia 10.1
30 pulmonary tuberculosis 10.1
31 filariasis 10.1
32 glomerulonephritis 10.0
33 erysipeloid 10.0
34 bacterial infectious disease 10.0
35 squamous cell carcinoma 10.0
36 vaccinia 10.0
37 myeloma, multiple 10.0
38 autoimmune hepatitis 10.0
39 paronychia 10.0
40 schistosomiasis 10.0
41 sporotrichosis 10.0
42 lymphopenia 10.0
43 human immunodeficiency virus type 1 10.0
44 lepromatous leprosy 10.0
45 toxoplasmosis 10.0
46 basal cell carcinoma 1 9.9
47 psoriatic arthritis 9.9
48 acute liver failure 9.9
49 chronic granulomatous disease 9.9
50 diabetes mellitus 9.9

Graphical network of the top 20 diseases related to Kala-Azar 1:



Diseases related to Kala-Azar 1

Symptoms & Phenotypes for Kala-Azar 1

Human phenotypes related to Kala-Azar 1:

60 (show all 25)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 splenomegaly 60 Very frequent (99-80%)
2 hepatomegaly 60 Very frequent (99-80%)
3 fatigue 60 Occasional (29-5%)
4 arthralgia 60 Frequent (79-30%)
5 anemia 60 Frequent (79-30%)
6 pancytopenia 60 Very frequent (99-80%)
7 pallor 60 Frequent (79-30%)
8 abnormal bleeding 60 Very frequent (99-80%)
9 weight loss 60 Frequent (79-30%)
10 elevated hepatic transaminases 60 Frequent (79-30%)
11 thrombocytopenia 60 Occasional (29-5%)
12 skin ulcer 60 Very frequent (99-80%)
13 anorexia 60 Occasional (29-5%)
14 papule 60 Very frequent (99-80%)
15 lymphadenopathy 60 Very frequent (99-80%)
16 abnormality of oral mucosa 60 Very frequent (99-80%)
17 increased antibody level in blood 60 Frequent (79-30%)
18 leukopenia 60 Occasional (29-5%)
19 abnormality of the oral cavity 60 Very frequent (99-80%)
20 skin plaque 60 Very frequent (99-80%)
21 hypoalbuminemia 60 Frequent (79-30%)
22 episodic fever 60 Very frequent (99-80%)
23 abnormality of macrophages 60 Very frequent (99-80%)
24 rhinitis 60 Very frequent (99-80%)
25 night sweats 60 Very frequent (99-80%)

Clinical features from OMIM:

608207

UMLS symptoms related to Kala-Azar 1:


fever, pruritus, exanthema

Drugs & Therapeutics for Kala-Azar 1

Search Clinical Trials , NIH Clinical Center for Kala-Azar 1

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Kala-Azar 1

Anatomical Context for Kala-Azar 1

MalaCards organs/tissues related to Kala-Azar 1:

42
Testes, T Cells, Skin, Bone, Bone Marrow, B Cells, Spleen

Publications for Kala-Azar 1

Articles related to Kala-Azar 1:

(show top 50) (show all 2295)
# Title Authors Year
1
Tissue and Blood Protozoa including Toxoplasmosis, Chagas disease, Leishmaniasis, Babesia, Acanthamoeba, Balamuthia, & Naegleria in Solid Organ Transplant Recipients - Guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation. ( 30900295 )
2019
2
The activity of encapsulated meglumine antimoniate in stearylamine-bearing liposomes against cutaneous leishmaniasis in BALB/c mice. ( 30898544 )
2019
3
Expansion of urban cutaneous leishmaniasis into rural areas of southeastern Iran: Clinical, epidemiological and phylogenetic profiles explored using 7SL high resolution melting-PCR analysis. ( 30912874 )
2019
4
Gene expression profile of cytokines produced in biopsies from patients with American cutaneous leishmaniasis. ( 30273562 )
2019
5
Fractional Ablative CO2 Laser Followed by Topical Application of Sodium Stibogluconate for Treatment of Active Cutaneous Leishmaniasis: A Randomized Controlled Trial. ( 30281141 )
2019
6
Case Reports: Late Emergence of Cutaneous Leishmaniasis in an Immunocompromised Patient in a Non-Endemic Setting. ( 30520412 )
2019
7
Presence of parasite DNA in clinically unaffected nasal mucosa during cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis. ( 30616010 )
2019
8
Evaluation of point of care tests for the diagnosis of cutaneous leishmaniasis in Suriname. ( 30616544 )
2019
9
Microneedle-Based Delivery of Amphotericin B for Treatment of Cutaneous Leishmaniasis. ( 30617619 )
2019
10
Endemic Human Cutaneous Leishmaniasis Incidence in the United States-Reply. ( 30624559 )
2019
11
Endemic Human Cutaneous Leishmaniasis Incidence in the United States. ( 30624563 )
2019
12
Eligibility for Local Therapies in Adolescents and Adults with Cutaneous Leishmaniasis from Southwestern Colombia: A Cross-Sectional Study. ( 30628567 )
2019
13
Autochthonous cutaneous leishmaniasis in urban domestic animals (Felis catus / Canis lupus familiaris) from central-western Venezuela. ( 30633896 )
2019
14
Assessment of intralesional cytokine profile of cutaneous leishmaniasis caused by Leishmania donovani in Sri Lanka. ( 30642262 )
2019
15
Label-free quantitative proteomic analysis reveals potential biomarkers for early healing in cutaneous leishmaniasis. ( 30648003 )
2019
16
Anti-TNF-associated cutaneous leishmaniasis: a single-institution experience. ( 30659588 )
2019
17
Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1. ( 30665936 )
2019
18
How cutaneous leishmaniasis and treatment impacts in the patients' lives: A cross-sectional study. ( 30682151 )
2019
19
The increasead of neglected cutaneous leishmaniasis in Gaziantep province of Turkey after mass human migration. ( 30710533 )
2019
20
Cutaneous Leishmaniasis: Updates in Diagnosis and Management. ( 30712756 )
2019
21
Isolated conjunctival involvement in a case of cutaneous leishmaniasis. ( 30722746 )
2019
22
Detection, genotyping, and phylogenetic analysis of Leishmania isolates collected from infected Jordanian residents and Syrian refugees who suffered from cutaneous leishmaniasis. ( 30729301 )
2019
23
Intralesional sodium stibogluconate under inhaled anesthesia for the treatment of cutaneous leishmaniasis in children: A retrospective cohort. ( 30731176 )
2019
24
Protection induced by Leishmania Major antigens and the imiquimod adjuvant encapsulated on liposomes in experimental cutaneous leishmaniasis. ( 30738195 )
2019
25
Host's immune response in unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis treated by meglumine antimoniate: A case-control study of Th1 and Th2 pathways. ( 30771740 )
2019
26
Rhinophyma-Like Cutaneous Leishmaniasis due to Leishmania aethiopica Treated Successfully with Liposomal Amphotericin B. ( 30774067 )
2019
27
Chitosan-based biocompatible dressing for treatment of recalcitrant lesions of cutaneous leishmaniasis: A pilot clinical study. ( 30785121 )
2019
28
Leishmania spp. Infection Rate and Feeding Patterns of Sand Flies (Diptera: Psychodidae) from a Hyperendemic Cutaneous Leishmaniasis Community in Panamá. ( 30793681 )
2019
29
Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates. ( 30802261 )
2019
30
Thirty years of cutaneous leishmaniasis in Tadla-Azilal focus, Morocco. ( 30805563 )
2019
31
Histological and immunological differences between zoonotic cutaneous leishmaniasis due to Leishmania major and sporadic cutaneous leishmaniasis due to Leishmania infantum. ( 30810524 )
2019
32
Anti-leishmanial activity of a topical miltefosine gel in experimental models of New World cutaneous leishmaniasis. ( 30815688 )
2019
33
Diel periodicity and visual cues guide oviposition behavior in Phlebotomus papatasi, vector of old-world cutaneous leishmaniasis. ( 30835733 )
2019
34
Disseminated Cutaneous Leishmaniasis in a Patient Infected by Leishmania panamensis. ( 30843505 )
2019
35
Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis. ( 30845223 )
2019
36
Imported cutaneous leishmaniasis: a 13-year experience of a Polish tertiary center. ( 30858788 )
2019
37
Alterations in monocyte subsets and cytokine production after TLR activation in American Cutaneous Leishmaniasis. ( 30870579 )
2019
38
Performance of immunohistochemistry as a useful tool for the diagnosis of cutaneous leishmaniasis in Panama, Central America. ( 30885795 )
2019
39
10-Year Trends in Epidemiology, Diagnosis, and Treatment of Cutaneous Leishmaniasis in Hamadan Province, West of Iran (2007-2016). ( 30891438 )
2019
40
Randomized, double-blind study on intralesional metronidazole versus intralesional sodium stibogluconate in Leishmania donovani cutaneous leishmaniasis. ( 29764246 )
2019
41
Residual Efficacy of Insecticides Sprayed on Different Types of Surfaces Against Leishmaniasis and Filariasis Vectors in Egypt. ( 30753681 )
2019
42
Visceral Leishmaniasis and Glomerulonephritis: A Case Report. ( 30787856 )
2019
43
Association between Insulin-Like Growth Factor-I Levels and the Disease Progression and Anemia in Visceral Leishmaniasis. ( 30761980 )
2019
44
Good response to pentamidine isethionate in a case of Mucosal Leishmaniasis caused by Leishmania (Viannia) braziliensis that was difficult to treat: Case Report. ( 30652793 )
2019
45
A randomized trial of AmBisome monotherapy and AmBisome and miltefosine combination to treat visceral leishmaniasis in HIV co-infected patients in Ethiopia. ( 30653490 )
2019
46
Unusual manifestations of visceral leishmaniasis in children: a case series and its spatial dispersion in the western region of São Paulo state, Brazil. ( 30658589 )
2019
47
Accuracy of a TaqMan-based real-time polymerase chain reaction combined to a Novy-MacNeal-Nicolle medium culture for the diagnosis of American tegumentary leishmaniasis. ( 30659669 )
2019
48
Eliminating visceral leishmaniasis in South Asia: the road ahead. ( 30670453 )
2019
49
Visceral Leishmaniasis. ( 30673546 )
2019
50
Comorbid infections induce progression of visceral leishmaniasis. ( 30674329 )
2019

Variations for Kala-Azar 1

Expression for Kala-Azar 1

Search GEO for disease gene expression data for Kala-Azar 1.

Pathways for Kala-Azar 1

GO Terms for Kala-Azar 1

Sources for Kala-Azar 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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