Aliases & Classifications for Kashin-Beck Disease

MalaCards integrated aliases for Kashin-Beck Disease:

Name: Kashin-Beck Disease 41 73

External Ids:

UMLS 73 C2745963

Summaries for Kashin-Beck Disease

MalaCards based summary : Kashin-Beck Disease is related to osteoarthritis and systemic onset juvenile idiopathic arthritis. An important gene associated with Kashin-Beck Disease is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Selenic acid and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include bone and endothelial, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Kashin–Beck disease (KBD) is a chronic, endemic type of osteochondropathy (disease of the bone) that is... more...

Related Diseases for Kashin-Beck Disease

Diseases related to Kashin-Beck Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 osteoarthritis 11.8
2 systemic onset juvenile idiopathic arthritis 10.6 IL1B TNF
3 staphylococcal toxic shock syndrome 10.6 IL1B TNF
4 autoimmune myocarditis 10.6 IL1B TNF
5 vulvar vestibulitis syndrome 10.6 IL1B TNF
6 burns 10.6 IL1B TNF
7 laryngitis 10.6 IL1B TNF
8 cerebral artery occlusion 10.6 IL1B TNF
9 haemophilus influenzae 10.6 IL1B TNF
10 retinitis pigmentosa 60 10.6 IL1B TNF
11 irritant dermatitis 10.6 IL1B TNF
12 acute vascular insufficiency of intestine 10.6 IL1B TNF
13 actinic prurigo 10.6 IL1B TNF
14 poems syndrome 10.6 IL1B TNF
15 crohn's colitis 10.6 IL1B TNF
16 central nervous system vasculitis 10.6 IL1B TNF
17 osteosclerotic myeloma 10.6 IL1B TNF
18 stachybotrys chartarum 10.6 IL1B TNF
19 dental pulp disease 10.6 IL1B TNF
20 jejunoileitis 10.6 IL1B TNF
21 eales disease 10.6 IL1B TNF
22 blau syndrome 10.5 IL1B TNF
23 endometritis 10.5 IL1B TNF
24 aseptic meningitis 10.5 IL1B TNF
25 scrub typhus 10.5 IL1B TNF
26 joint disorders 10.5 IL1B TNF
27 pulpitis 10.5 IL1B TNF
28 middle ear disease 10.5 IL1B TNF
29 pleural disease 10.5 IL1B TNF
30 commensal bacterial infectious disease 10.5 IL1B TNF
31 q fever 10.5 IL1B TNF
32 lacrimal apparatus disease 10.5 IL1B TNF
33 adult-onset still's disease 10.5 IL1B TNF
34 soft tissue sarcoma 10.5 BCL2 TNF
35 perinatal necrotizing enterocolitis 10.5 IL1B TNF
36 aphthous stomatitis 10.5 IL1B TNF
37 palindromic rheumatism 10.5 IL1B TNF
38 dengue shock syndrome 10.5 IL1B TNF
39 extrinsic cardiomyopathy 10.5 IL1B TNF
40 viral encephalitis 10.5 IL1B TNF
41 complex regional pain syndrome 10.5 IL1B TNF
42 idiopathic neutropenia 10.5 IL1B TNF
43 uterine anomalies 10.5 IL1B TNF
44 chikungunya 10.4 IL1B TNF
45 keratoconjunctivitis sicca 10.4 IL1B TNF
46 prostatitis 10.4 IL1B TNF
47 acute respiratory distress syndrome 10.4 IL1B TNF
48 euthyroid sick syndrome 10.4 DIO2 IL1B
49 bacterial vaginosis 10.4 IL1B TNF
50 intracranial hypertension 10.4 IL1B TNF

Graphical network of the top 20 diseases related to Kashin-Beck Disease:



Diseases related to Kashin-Beck Disease

Symptoms & Phenotypes for Kashin-Beck Disease

GenomeRNAi Phenotypes related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 FAS IL1B TNF BAX BCL2
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 FAS IL1B TNF BAX BCL2

MGI Mouse Phenotypes related to Kashin-Beck Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 BCL2 FAS IL1B TNF BAX TXNRD2
2 homeostasis/metabolism MP:0005376 9.8 DIO2 FAS IL1B TNF BAX TXNRD2
3 endocrine/exocrine gland MP:0005379 9.77 BCL2 DIO2 FAS TNF BAX
4 neoplasm MP:0002006 9.55 FAS IL1B TNF BAX BCL2
5 nervous system MP:0003631 9.43 BCL2 FAS IL1B TNF BAX TXNRD2
6 skeleton MP:0005390 9.02 DIO2 FAS IL1B TNF BAX

Drugs & Therapeutics for Kashin-Beck Disease

Drugs for Kashin-Beck Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Selenic acid Approved Phase 2 7783-08-6
2 Antioxidants Phase 2
3 Protective Agents Phase 2
4 Garcinia Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antioxidant Supplementation in Patients With Kashin-Beck Disease Unknown status NCT00376025 Phase 2

Search NIH Clinical Center for Kashin-Beck Disease

Genetic Tests for Kashin-Beck Disease

Anatomical Context for Kashin-Beck Disease

MalaCards organs/tissues related to Kashin-Beck Disease:

41
Bone, Endothelial

Publications for Kashin-Beck Disease

Articles related to Kashin-Beck Disease:

(show top 50) (show all 118)
# Title Authors Year
1
Imbalance of dietary nutrients and the associated differentially expressed genes and pathways may play important roles in juvenile Kashin-Beck disease. ( 29426639 )
2018
2
Polymorphism in rs2229783 of the Alpha 1(XI) Collagen Gene Is Associated with Susceptibility to but not Severity of Kashin-Beck Disease in a Northwest Chinese Han Population. ( 29773097 )
2018
3
The Importance of Se-Related Genes in the Chondrocyte of Kashin-Beck Disease Revealed by Whole Genomic Microarray and Network Analysis. ( 29948913 )
2018
4
Dietary exosome-miR-23b may be a novel therapeutic measure for preventing Kashin-Beck disease. ( 29556257 )
2018
5
Outcomes of total knee arthroplasty in the adult Kashin-Beck disease with severe osteoarthritis. ( 29971707 )
2018
6
Comparative Analysis of Gene Expression Profiles of Human Dental Fluorosis and Kashin-Beck Disease. ( 29317700 )
2018
7
The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease. ( 29653292 )
2018
8
Serum levels of PIICP, PIIANP, and PIIBNP are decreased in patients with an endemic osteochondropathy, Kashin-Beck disease. ( 29843748 )
2018
9
The characteristics of positive and confusing hand X-ray signs in diagnosing Kashin-Beck Disease in children in China. ( 29459762 )
2018
10
Integrating genome-wide DNA methylation and mRNA expression profiles identified different molecular features between Kashin-Beck disease and primary osteoarthritis. ( 29514696 )
2018
11
Prevalence of hand osteoarthritis and knee osteoarthritis in Kashin-Beck disease endemic areas and non Kashin-Beck disease endemic areas: A status survey. ( 29320581 )
2018
12
FGF8 and FGFR3 are up-regulated in hypertrophic chondrocytes: Association with chondrocyte death in deep zone of Kashin-Beck disease. ( 29626475 )
2018
13
Effects of five types of selenium supplementation for treatment of Kashin-Beck disease in children: a systematic review and network meta-analysis. ( 29511006 )
2018
14
Genome-wide DNA methylation profiling of articular cartilage reveals significant epigenetic alterations in Kashin-Beck disease and osteoarthritis. ( 28818737 )
2017
15
Altered expression of chondroitin sulfate structure modifying sulfotransferases in the articular cartilage from adult osteoarthritis and Kashin-Beck disease. ( 28274888 )
2017
16
Evaluation of the Sensitivity and Specificity of the New Clinical Diagnostic and Classification Criteria for Kashin-Beck Disease, an Endemic Osteoarthritis, in China. ( 28292355 )
2017
17
Zinc: the Other Suspected Environmental Factor in Kashin-Beck Disease in Addition to Selenium. ( 28224461 )
2017
18
Association study of candidate genes for susceptibility to Kashin-Beck disease in a Tibetan population. ( 28651521 )
2017
19
Long noncoding RNA expression profile reveals lncRNAs signature associated with extracellular matrix degradation in kashin-beck disease. ( 29242531 )
2017
20
The expression of ERK and JNK in patients with an endemic osteochondropathy, Kashin-Beck disease. ( 28807789 )
2017
21
Associations Between Selenium Content in Hair and Kashin-Beck Disease/Keshan Disease in Children in Northwestern China: a Prospective Cohort Study. ( 28983831 )
2017
22
Comparison of microRNA expression profiles of Kashin-Beck disease, osteoarthritis and rheumatoid arthritis. ( 28373711 )
2017
23
Chondrocytes damage induced by T-2 toxin via Wnt/I^-catenin signaling pathway is involved in the pathogenesis of an endemic osteochondropathy, Kashin-Beck disease. ( 29042209 )
2017
24
Selenium status of children in Kashin-Beck disease endemic areas in Shaanxi, China: assessment with mercury. ( 29018984 )
2017
25
Increased Chondrocyte Apoptosis in Kashin-Beck Disease and Rats Induced by T-2 Toxin and Selenium Deficiency. ( 28549491 )
2017
26
Nutrients Other than Selenium Are Important for Promoting Children's Health in Kashin-Beck Disease Areas. ( 28921450 )
2017
27
Genome-wide association study identifies COL2A1 locus involved in the hand development failure of Kashin-Beck disease. ( 28059113 )
2017
28
Detection of the Urinary Biomarkers PYD, CTX-II, and DPD in Patients with Kashin-Beck Disease in the Qinghai Province of China. ( 28549495 )
2017
29
Reliability and validity of the 12-item WHODAS 2.0 in patients with Kashin-Beck disease. ( 28439626 )
2017
30
Genetic association, mRNA and protein expression analysis identify ATG4C as a susceptibility gene for Kashin-Beck disease. ( 27742532 )
2017
31
The efficacy and safety of intra-articular injection of hyaluronic acid in the knee and physical therapy agents to treat Kashin-Beck disease: A prospective interventional study. ( 27446269 )
2016
32
PPARGC1B gene is associated with Kashin-Beck disease in Han Chinese. ( 27108113 )
2016
33
Accidental or linked: separated odontoid process fused to the enlarged anterior arch of the atlas associated with atlantoaxial subluxation in a Kashin-Beck disease patient. ( 27652680 )
2016
34
Distribution and translocation of selenium from soil to highland barley in the Tibetan Plateau Kashin-Beck disease area. ( 27071616 )
2016
35
Comparative analysis of signaling pathways in peripheral blood from patients with Kashin-Beck disease and osteoarthritis. ( 28101186 )
2016
36
Reliability and validity of the EQ-5D-3L for Kashin-Beck disease in China. ( 27917330 )
2016
37
Effects of sodium selenite on c-Jun N-terminal kinase signalling pathway induced by oxidative stress in human chondrocytes and c-Jun N-terminal kinase expression in patients with Kashin-Beck disease, an endemic osteoarthritis. ( 26948765 )
2016
38
Exploring Genome-wide DNA Methylation Profiles Altered in Kashin-Beck Disease Using Infinium Human Methylation 450 Bead Chips. ( 27554126 )
2016
39
Population-based comparative analysis of differentially expressed genes between Kashin-Beck disease grades I and II. ( 26767981 )
2016
40
Investigation of MMP-1 genetic polymorphisms and protein expression and their effects on the risk of Kashin-Beck disease in the northwest Chinese Han population. ( 27245218 )
2016
41
Evaluation of the relationship and genetic overlap between Kashin-Beck disease and body mass index. ( 27053287 )
2016
42
The roles of selenium, insulin-like growth factor binding protein 2 and suppressor of cytokine signaling 3 in the pathogenesis of Kashin-Beck disease. ( 27099071 )
2016
43
Field synopsis and meta-analyses of genetic epidemiological evidence for Kashin-Beck disease, an endemic osteoarthropathy in China. ( 27256326 )
2016
44
Staged total knee arthroplasty for bilateral complex knee deformities from Kashin-Beck disease and skeletal dysplasia. ( 27923623 )
2016
45
A bivariate genome-wide association study identifies ADAM12 as a novel susceptibility gene for Kashin-Beck disease. ( 27545300 )
2016
46
Effect of calcium and vitamin D on growth, rickets and Kashin-Beck disease in 0-5 year old children in a rural area of Central Tibet. ( 27102369 )
2016
47
Reliability and validation of the joint dysfunction index as a new assessment instrument for therapeutic efficacy for Kashin-Beck disease. ( 27094942 )
2016
48
Total hip replacement in adult patients with severe Kashin-Beck disease of the hip. ( 27422624 )
2016
49
Integrative Multivariate Logistic Regression Analysis of Risk Factors for Kashin-Beck disease. ( 27113769 )
2016
50
Identified molecular mechanism of interaction between environmental risk factors and differential expression genes in cartilage of Kashin-Beck disease. ( 28033256 )
2016

Variations for Kashin-Beck Disease

Expression for Kashin-Beck Disease

Search GEO for disease gene expression data for Kashin-Beck Disease.

Pathways for Kashin-Beck Disease

Pathways related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.47 BAX BCL2 FAS IL1B TNF
2
Show member pathways
13.21 BAX BCL2 FAS IL1B TNF
3
Show member pathways
12.91 BAX BCL2 FAS IL1B TNF TXNRD2
4
Show member pathways
12.84 BCL2 FAS IL1B TNF
5
Show member pathways
12.81 BAX BCL2 FAS TNF
6
Show member pathways
12.71 BAX BCL2 FAS TNF
7 12.67 BAX BCL2 FAS TXNRD2
8
Show member pathways
12.64 BAX BCL2 FAS TNF
9
Show member pathways
12.51 FAS IL1B TNF
10
Show member pathways
12.49 BCL2 IL1B TNF
11 12.42 FAS IL1B TNF
12
Show member pathways
12.4 BAX BCL2 IL1B TNF
13
Show member pathways
12.38 BAX BCL2 FAS TNF
14
Show member pathways
12.37 BCL2 IL1B TNF
15
Show member pathways
12.34 BAX BCL2 IL1B
16
Show member pathways
12.31 BAX BCL2 IL1B
17
Show member pathways
12.29 FAS IL1B TNF
18
Show member pathways
12.24 BAX BCL2 FAS
19
Show member pathways
12.13 DIO2 IL1B TNF TXNRD2
20
Show member pathways
12.12 BAX BCL2 FAS
21
Show member pathways
12.12 BCL2 IL1B TNF
22
Show member pathways
12.05 FAS IL1B TNF
23 12.05 BAX BCL2 FAS TNF
24 11.99 BAX BCL2 IL1B TNF
25 11.96 BCL2 IL1B TNF
26 11.93 BAX BCL2 FAS
27
Show member pathways
11.89 BAX BCL2 TNF
28
Show member pathways
11.88 BAX BCL2 FAS TNF
29 11.87 BAX BCL2 TNF
30
Show member pathways
11.84 BAX BCL2 TNF
31 11.83 BCL2 IL1B TNF
32 11.8 FAS IL1B TNF
33 11.74 BCL2 IL1B TNF
34
Show member pathways
11.68 BAX BCL2 FAS
35 11.59 BAX BCL2 FAS
36 11.48 IL1B TNF
37 11.45 BAX BCL2 IL1B TNF
38 11.42 IL1B TNF
39 11.42 IL1B TNF
40 11.41 IL1B TNF
41 11.39 BAX BCL2
42 11.39 DIO2 TXNRD2
43 11.38 BAX IL1B TNF
44 11.37 IL1B TNF
45 11.36 FAS TNF
46
Show member pathways
11.35 IL1B TNF
47 11.33 BAX BCL2 TNF
48
Show member pathways
11.27 BAX BCL2 FAS
49 11.26 IL1B TNF
50
Show member pathways
11.26 BAX BCL2 FAS IL1B TNF

GO Terms for Kashin-Beck Disease

Cellular components related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pore complex GO:0046930 8.62 BAX BCL2

Biological processes related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.96 BAX BCL2 FAS IL1B
2 positive regulation of apoptotic process GO:0043065 9.89 BAX FAS TNF
3 regulation of apoptotic process GO:0042981 9.88 BAX BCL2 FAS
4 cytokine-mediated signaling pathway GO:0019221 9.88 BCL2 IL1B TNF
5 positive regulation of protein phosphorylation GO:0001934 9.81 FAS IL1B TNF
6 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.72 BAX FAS TNF
7 positive regulation of interleukin-6 production GO:0032755 9.71 IL1B TNF
8 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.71 IL1B TNF
9 protein kinase B signaling GO:0043491 9.7 IL1B TNF
10 positive regulation of interferon-gamma production GO:0032729 9.7 IL1B TNF
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.7 IL1B TNF
12 apoptotic signaling pathway GO:0097190 9.7 BAX FAS TNF
13 ovarian follicle development GO:0001541 9.69 BAX BCL2
14 neuron apoptotic process GO:0051402 9.69 BAX BCL2
15 positive regulation of phagocytosis GO:0050766 9.69 IL1B TNF
16 negative regulation of mitotic cell cycle GO:0045930 9.68 BCL2 TNF
17 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.68 BAX BCL2
18 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 IL1B TNF
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.68 IL1B TNF
20 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 9.67 BAX BCL2
21 response to gamma radiation GO:0010332 9.67 BAX BCL2
22 regulation of mitochondrial membrane potential GO:0051881 9.67 BAX BCL2
23 homeostasis of number of cells within a tissue GO:0048873 9.66 BAX BCL2
24 positive regulation of interleukin-8 production GO:0032757 9.66 IL1B TNF
25 release of cytochrome c from mitochondria GO:0001836 9.65 BAX BCL2
26 negative regulation of apoptotic signaling pathway GO:2001234 9.65 BAX BCL2
27 B cell homeostasis GO:0001782 9.64 BAX BCL2
28 apoptotic mitochondrial changes GO:0008637 9.64 BAX BCL2
29 negative regulation of lipid catabolic process GO:0050995 9.63 IL1B TNF
30 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IL1B TNF
31 endoplasmic reticulum calcium ion homeostasis GO:0032469 9.62 BAX BCL2
32 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.61 BAX FAS
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL1B TNF
34 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.61 BAX BCL2 TNF
35 response to salt stress GO:0009651 9.6 BAX TNF
36 regulation of protein heterodimerization activity GO:0043497 9.59 BAX BCL2
37 positive regulation of chemokine biosynthetic process GO:0045080 9.58 IL1B TNF
38 regulation of protein homodimerization activity GO:0043496 9.58 BAX BCL2
39 extrinsic apoptotic signaling pathway GO:0097191 9.58 BAX FAS TNF
40 ectopic germ cell programmed cell death GO:0035234 9.57 BAX IL1B
41 regulation of establishment of endothelial barrier GO:1903140 9.56 IL1B TNF
42 necroptotic signaling pathway GO:0097527 9.54 FAS TNF
43 cellular response to organic substance GO:0071310 9.54 BAX BCL2 IL1B
44 positive regulation of fever generation GO:0031622 9.51 IL1B TNF
45 leukocyte homeostasis GO:0001776 9.49 BAX BCL2
46 sequestering of triglyceride GO:0030730 9.48 IL1B TNF
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 IL1B TNF
48 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.33 BCL2 IL1B TNF
49 regulation of nitrogen utilization GO:0006808 9.32 BAX BCL2
50 positive regulation of developmental pigmentation GO:0048087 9.26 BAX BCL2

Molecular functions related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.46 BAX BCL2 FAS TNF
2 channel activity GO:0015267 8.96 BAX BCL2
3 BH3 domain binding GO:0051434 8.62 BAX BCL2

Sources for Kashin-Beck Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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