MCID: KSH004
MIFTS: 42

Kashin-Beck Disease

Categories: Bone diseases

Aliases & Classifications for Kashin-Beck Disease

MalaCards integrated aliases for Kashin-Beck Disease:

Name: Kashin-Beck Disease 42 17 74

Classifications:



External Ids:

UMLS 74 C2745963

Summaries for Kashin-Beck Disease

MalaCards based summary : Kashin-Beck Disease is related to osteoarthritis and rheumatoid arthritis. An important gene associated with Kashin-Beck Disease is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Selenic acid and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and monocytes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 77 Kashin–Beck disease (KBD) is a chronic, endemic type of osteochondropathy (disease of the bone) that is... more...

Related Diseases for Kashin-Beck Disease

Diseases related to Kashin-Beck Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 osteoarthritis 11.9
2 rheumatoid arthritis 10.5
3 arthritis 10.5
4 rickets 10.4
5 exudative glomerulonephritis 10.3 IL1B TNF
6 staphylococcal toxic shock syndrome 10.3 IL1B TNF
7 vulvar vestibulitis syndrome 10.3 IL1B TNF
8 burns 10.3 IL1B TNF
9 glossitis 10.3 IL1B TNF
10 laryngitis 10.3 IL1B TNF
11 haemophilus influenzae 10.3 IL1B TNF
12 cerebral artery occlusion 10.3 IL1B TNF
13 opisthorchiasis 10.3 IL1B TNF
14 retinitis pigmentosa 60 10.3 IL1B TNF
15 irritant dermatitis 10.3 IL1B TNF
16 acute vascular insufficiency of intestine 10.3 IL1B TNF
17 congenital cytomegalovirus 10.3 IL1B TNF
18 actinic prurigo 10.3 IL1B TNF
19 osteosclerotic myeloma 10.3 IL1B TNF
20 crohn's colitis 10.3 IL1B TNF
21 periapical periodontitis 10.3 IL1B TNF
22 autoimmune gastritis 10.3 IL1B TNF
23 central nervous system vasculitis 10.3 IL1B TNF
24 stachybotrys chartarum 10.3 IL1B TNF
25 jejunoileitis 10.3 IL1B TNF
26 endometrial disease 10.3 IL1B TNF
27 dental pulp disease 10.3 IL1B TNF
28 primary systemic mycosis 10.3 IL1B TNF
29 osteoporosis 10.3
30 cerebrotendinous xanthomatosis 10.3
31 body mass index quantitative trait locus 1 10.3
32 keshan disease 10.3
33 dental fluorosis 10.3
34 hypoxia 10.3
35 atlantoaxial subluxation 10.3
36 blau syndrome 10.3 IL1B TNF
37 endometritis 10.3 IL1B TNF
38 aseptic meningitis 10.3 IL1B TNF
39 scrub typhus 10.3 IL1B TNF
40 pulpitis 10.3 IL1B TNF
41 joint disorders 10.3 IL1B TNF
42 middle ear disease 10.3 IL1B TNF
43 lacrimal apparatus disease 10.3 IL1B TNF
44 adult-onset still's disease 10.3 IL1B TNF
45 commensal bacterial infectious disease 10.3 IL1B TNF
46 perinatal necrotizing enterocolitis 10.2 IL1B TNF
47 dengue shock syndrome 10.2 IL1B TNF
48 critical limb ischemia 10.2 TNF VEGFA
49 q fever 10.2 IL1B TNF
50 malignant teratoma 10.2 BAX BCL2

Graphical network of the top 20 diseases related to Kashin-Beck Disease:



Diseases related to Kashin-Beck Disease

Symptoms & Phenotypes for Kashin-Beck Disease

GenomeRNAi Phenotypes related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 BAX BCL2 FAS IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 BAX BCL2 FAS IL1B TNF

MGI Mouse Phenotypes related to Kashin-Beck Disease:

47 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.11 BAX BCL2 FAS IL1B SELENOP TNF
2 cellular MP:0005384 10.1 BAX BCL2 FAS SELENOP TNF TXNRD2
3 growth/size/body region MP:0005378 10.08 BAX BCL2 FAS IL1B SELENOP TNF
4 hematopoietic system MP:0005397 10.07 BAX BCL2 FAS IL1B TNF TXNRD2
5 cardiovascular system MP:0005385 10.04 BCL2 FAS IL1B TNF TXNRD2 VEGFA
6 immune system MP:0005387 10.04 BAX BCL2 FAS IL1B SELENOP TNF
7 mortality/aging MP:0010768 10.01 BAX BCL2 FAS IL1B SELENOP TNF
8 craniofacial MP:0005382 9.95 BCL2 FAS IL1B TNF VEGFA
9 integument MP:0010771 9.88 BCL2 FAS IL1B TNF VEGFA
10 limbs/digits/tail MP:0005371 9.85 BAX FAS SELENOP TNF VEGFA
11 liver/biliary system MP:0005370 9.83 FAS SELENOP TNF TXNRD2 VEGFA
12 neoplasm MP:0002006 9.8 BAX BCL2 FAS IL1B TNF VEGFA
13 nervous system MP:0003631 9.8 BAX BCL2 FAS IL1B TNF TXNRD2
14 muscle MP:0005369 9.77 BAX BCL2 TNF TXNRD2 VEGFA
15 renal/urinary system MP:0005367 9.55 BAX BCL2 FAS SELENOP VEGFA
16 reproductive system MP:0005389 9.43 BAX BCL2 FAS SELENOP TNF VEGFA
17 vision/eye MP:0005391 9.02 BAX BCL2 FAS TNF VEGFA

Drugs & Therapeutics for Kashin-Beck Disease

Drugs for Kashin-Beck Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Selenic acid Approved Phase 2 7783-08-6
2 Antioxidants Phase 2
3 Garcinia Phase 2
4 Protective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antioxidant Supplementation in Patients With Kashin-Beck Disease Unknown status NCT00376025 Phase 2

Search NIH Clinical Center for Kashin-Beck Disease

Genetic Tests for Kashin-Beck Disease

Anatomical Context for Kashin-Beck Disease

MalaCards organs/tissues related to Kashin-Beck Disease:

42
Bone, Endothelial, Monocytes

Publications for Kashin-Beck Disease

Articles related to Kashin-Beck Disease:

(show top 50) (show all 210)
# Title Authors Year
1
The levels of urine CTX-II, C2C, and PYD in children patients with Kashin-Beck disease in Qinghai Province of China. ( 30635000 )
2019
2
Decreased Expression of CHST-12, CHST-13, and UST in the Proximal Interphalangeal Joint Cartilage of School-Age Children with Kashin-Beck Disease: an Endemic Osteoarthritis in China Caused by Selenium Deficiency. ( 30661165 )
2019
3
Death of chondrocytes in Kashin-Beck disease: Apoptosis, necrosis or necroptosis? ( 30680829 )
2019
4
Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China. ( 30719180 )
2019
5
The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016. ( 30764809 )
2019
6
Imbalance of dietary nutrients and the associated differentially expressed genes and pathways may play important roles in juvenile Kashin-Beck disease. ( 29426639 )
2018
7
Polymorphism in rs2229783 of the Alpha 1(XI) Collagen Gene Is Associated with Susceptibility to but not Severity of Kashin-Beck Disease in a Northwest Chinese Han Population. ( 29773097 )
2018
8
The Importance of Se-Related Genes in the Chondrocyte of Kashin-Beck Disease Revealed by Whole Genomic Microarray and Network Analysis. ( 29948913 )
2018
9
Dietary exosome-miR-23b may be a novel therapeutic measure for preventing Kashin-Beck disease. ( 29556257 )
2018
10
Outcomes of total knee arthroplasty in the adult Kashin-Beck disease with severe osteoarthritis. ( 29971707 )
2018
11
Comparative Analysis of Gene Expression Profiles of Human Dental Fluorosis and Kashin-Beck Disease. ( 29317700 )
2018
12
The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease. ( 29653292 )
2018
13
Serum levels of PIICP, PIIANP, and PIIBNP are decreased in patients with an endemic osteochondropathy, Kashin-Beck disease. ( 29843748 )
2018
14
The characteristics of positive and confusing hand X-ray signs in diagnosing Kashin-Beck Disease in children in China. ( 29459762 )
2018
15
Integrating genome-wide DNA methylation and mRNA expression profiles identified different molecular features between Kashin-Beck disease and primary osteoarthritis. ( 29514696 )
2018
16
Prevalence of hand osteoarthritis and knee osteoarthritis in Kashin-Beck disease endemic areas and non Kashin-Beck disease endemic areas: A status survey. ( 29320581 )
2018
17
FGF8 and FGFR3 are up-regulated in hypertrophic chondrocytes: Association with chondrocyte death in deep zone of Kashin-Beck disease. ( 29626475 )
2018
18
Effects of five types of selenium supplementation for treatment of Kashin-Beck disease in children: a systematic review and network meta-analysis. ( 29511006 )
2018
19
RNA-seq analysis reveals different gene ontologies and pathways in rheumatoid arthritis and Kashin-Beck disease. ( 30256536 )
2018
20
The study of GPX3 methylation in patients with Kashin-Beck Disease and its mechanism in chondrocyte apoptosis. ( 30153510 )
2018
21
Long-term efficacy of repeated sodium hyaluronate injections in adult patients with Kashin-Beck disease of the knee. ( 30460780 )
2018
22
Comparison of bone texture between normal individuals and patients with Kashin-Beck disease from plain radiographs in knee. ( 30504816 )
2018
23
Genome-wide DNA methylation profiling of articular cartilage reveals significant epigenetic alterations in Kashin-Beck disease and osteoarthritis. ( 28818737 )
2017
24
Altered expression of chondroitin sulfate structure modifying sulfotransferases in the articular cartilage from adult osteoarthritis and Kashin-Beck disease. ( 28274888 )
2017
25
Evaluation of the Sensitivity and Specificity of the New Clinical Diagnostic and Classification Criteria for Kashin-Beck Disease, an Endemic Osteoarthritis, in China. ( 28292355 )
2017
26
Zinc: the Other Suspected Environmental Factor in Kashin-Beck Disease in Addition to Selenium. ( 28224461 )
2017
27
Association study of candidate genes for susceptibility to Kashin-Beck disease in a Tibetan population. ( 28651521 )
2017
28
Long noncoding RNA expression profile reveals lncRNAs signature associated with extracellular matrix degradation in kashin-beck disease. ( 29242531 )
2017
29
The expression of ERK and JNK in patients with an endemic osteochondropathy, Kashin-Beck disease. ( 28807789 )
2017
30
Associations Between Selenium Content in Hair and Kashin-Beck Disease/Keshan Disease in Children in Northwestern China: a Prospective Cohort Study. ( 28983831 )
2017
31
Comparison of microRNA expression profiles of Kashin-Beck disease, osteoarthritis and rheumatoid arthritis. ( 28373711 )
2017
32
Chondrocytes damage induced by T-2 toxin via Wnt/I^-catenin signaling pathway is involved in the pathogenesis of an endemic osteochondropathy, Kashin-Beck disease. ( 29042209 )
2017
33
Selenium status of children in Kashin-Beck disease endemic areas in Shaanxi, China: assessment with mercury. ( 29018984 )
2017
34
Increased Chondrocyte Apoptosis in Kashin-Beck Disease and Rats Induced by T-2 Toxin and Selenium Deficiency. ( 28549491 )
2017
35
Nutrients Other than Selenium Are Important for Promoting Children's Health in Kashin-Beck Disease Areas. ( 28921450 )
2017
36
Genome-wide association study identifies COL2A1 locus involved in the hand development failure of Kashin-Beck disease. ( 28059113 )
2017
37
Detection of the Urinary Biomarkers PYD, CTX-II, and DPD in Patients with Kashin-Beck Disease in the Qinghai Province of China. ( 28549495 )
2017
38
Reliability and validity of the 12-item WHODAS 2.0 in patients with Kashin-Beck disease. ( 28439626 )
2017
39
Genetic association, mRNA and protein expression analysis identify ATG4C as a susceptibility gene for Kashin-Beck disease. ( 27742532 )
2017
40
The efficacy and safety of intra-articular injection of hyaluronic acid in the knee and physical therapy agents to treat Kashin-Beck disease: A prospective interventional study. ( 27446269 )
2016
41
PPARGC1B gene is associated with Kashin-Beck disease in Han Chinese. ( 27108113 )
2016
42
Accidental or linked: separated odontoid process fused to the enlarged anterior arch of the atlas associated with atlantoaxial subluxation in a Kashin-Beck disease patient. ( 27652680 )
2016
43
Distribution and translocation of selenium from soil to highland barley in the Tibetan Plateau Kashin-Beck disease area. ( 27071616 )
2016
44
Comparative analysis of signaling pathways in peripheral blood from patients with Kashin-Beck disease and osteoarthritis. ( 28101186 )
2016
45
Reliability and validity of the EQ-5D-3L for Kashin-Beck disease in China. ( 27917330 )
2016
46
Effects of sodium selenite on c-Jun N-terminal kinase signalling pathway induced by oxidative stress in human chondrocytes and c-Jun N-terminal kinase expression in patients with Kashin-Beck disease, an endemic osteoarthritis. ( 26948765 )
2016
47
Exploring Genome-wide DNA Methylation Profiles Altered in Kashin-Beck Disease Using Infinium Human Methylation 450 Bead Chips. ( 27554126 )
2016
48
Population-based comparative analysis of differentially expressed genes between Kashin-Beck disease grades I and II. ( 26767981 )
2016
49
Investigation of MMP-1 genetic polymorphisms and protein expression and their effects on the risk of Kashin-Beck disease in the northwest Chinese Han population. ( 27245218 )
2016
50
Evaluation of the relationship and genetic overlap between Kashin-Beck disease and body mass index. ( 27053287 )
2016

Variations for Kashin-Beck Disease

Expression for Kashin-Beck Disease

Search GEO for disease gene expression data for Kashin-Beck Disease.

Pathways for Kashin-Beck Disease

Pathways related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 BAX BCL2 FAS IL1B TNF VEGFA
2
Show member pathways
13.37 BAX BCL2 IL1B TNF VEGFA
3
Show member pathways
13.26 BAX BCL2 FAS IL1B TNF
4
Show member pathways
13.1 BAX BCL2 FAS IL1B TNF TXNRD2
5
Show member pathways
13.05 BCL2 FAS IL1B TNF
6
Show member pathways
12.83 BAX BCL2 FAS TNF VEGFA
7
Show member pathways
12.8 BAX BCL2 FAS TNF VEGFA
8
Show member pathways
12.75 FAS IL1B TNF VEGFA
9
Show member pathways
12.68 BAX BCL2 FAS TNF
10 12.67 BAX BCL2 FAS TXNRD2 VEGFA
11 12.63 FAS IL1B TNF VEGFA
12
Show member pathways
12.53 BAX BCL2 FAS IL1B TNF VEGFA
13
Show member pathways
12.47 BAX BCL2 IL1B TNF
14
Show member pathways
12.43 BAX BCL2 FAS IL1B TNF
15
Show member pathways
12.39 BCL2 FAS IL1B TNF VEGFA
16
Show member pathways
12.36 BAX BCL2 IL1B
17
Show member pathways
12.33 BAX BCL2 IL1B
18
Show member pathways
12.32 FAS IL1B TNF
19
Show member pathways
12.27 BAX BCL2 FAS
20
Show member pathways
12.21 IL1B SELENOP TNF TXNRD2
21 12.19 FAS TNF VEGFA
22
Show member pathways
12.15 BCL2 IL1B TNF
23
Show member pathways
12.15 BAX BCL2 FAS
24
Show member pathways
12.15 BAX BCL2 FAS TNF
25
Show member pathways
12.09 FAS IL1B TNF
26 12.09 BAX BCL2 FAS TNF
27 12.08 BAX TNF VEGFA
28 12.08 IL1B TNF VEGFA
29 12.06 BAX BCL2 IL1B TNF
30 12.05 BAX BCL2 VEGFA
31 11.97 BAX BCL2 FAS
32
Show member pathways
11.93 BAX BCL2 TNF
33 11.91 BAX BCL2 TNF
34
Show member pathways
11.89 BAX BCL2 TNF
35 11.87 FAS IL1B TNF
36 11.85 BCL2 IL1B TNF VEGFA
37 11.8 BCL2 IL1B TNF
38 11.77 IL1B TNF VEGFA
39
Show member pathways
11.73 BAX BCL2 FAS
40 11.73 BCL2 IL1B TNF VEGFA
41 11.66 BAX BCL2 FAS
42
Show member pathways
11.59 BAX BCL2 FAS IL1B TNF
43
Show member pathways
11.58 IL1B TNF VEGFA
44 11.44 BAX IL1B TNF
45 11.41 BAX BCL2
46 11.41 SELENOP TXNRD2
47 11.4 IL1B TNF
48 11.39 FAS TNF
49 11.39 BAX BCL2 TNF
50
Show member pathways
11.37 IL1B TNF

GO Terms for Kashin-Beck Disease

Cellular components related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pore complex GO:0046930 8.62 BAX BCL2

Biological processes related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.89 BAX BCL2 FAS
2 cytokine-mediated signaling pathway GO:0019221 9.88 BCL2 IL1B TNF VEGFA
3 kidney development GO:0001822 9.83 BAX BCL2 VEGFA
4 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.81 BAX FAS TNF
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.79 BCL2 TNF VEGFA
6 post-embryonic development GO:0009791 9.78 BAX BCL2 SELENOP
7 positive regulation of interferon-gamma production GO:0032729 9.73 IL1B TNF
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 IL1B TNF
9 positive regulation of phagocytosis GO:0050766 9.72 IL1B TNF
10 protein kinase B signaling GO:0043491 9.72 IL1B TNF
11 neuron apoptotic process GO:0051402 9.72 BAX BCL2
12 apoptotic signaling pathway GO:0097190 9.72 BAX FAS TNF
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 IL1B TNF
14 negative regulation of mitotic cell cycle GO:0045930 9.71 BCL2 TNF
15 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.71 BAX BCL2
16 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 9.71 BAX BCL2
17 homeostasis of number of cells within a tissue GO:0048873 9.71 BAX BCL2
18 positive regulation of protein phosphorylation GO:0001934 9.71 FAS IL1B TNF VEGFA
19 positive regulation of p38MAPK cascade GO:1900745 9.7 IL1B VEGFA
20 regulation of mitochondrial membrane potential GO:0051881 9.7 BAX BCL2
21 positive regulation of interleukin-8 production GO:0032757 9.7 IL1B TNF
22 negative regulation of apoptotic signaling pathway GO:2001234 9.69 BAX BCL2
23 negative regulation of neurogenesis GO:0050768 9.69 IL1B TNF
24 positive regulation of protein complex assembly GO:0031334 9.69 TNF VEGFA
25 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.69 BAX BCL2 TNF
26 B cell homeostasis GO:0001782 9.68 BAX BCL2
27 apoptotic mitochondrial changes GO:0008637 9.68 BAX BCL2
28 release of cytochrome c from mitochondria GO:0001836 9.68 BAX BCL2
29 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.68 IL1B VEGFA
30 negative regulation of lipid catabolic process GO:0050995 9.67 IL1B TNF
31 positive regulation of glial cell proliferation GO:0060252 9.67 IL1B TNF
32 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.67 IL1B TNF
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.66 IL1B TNF
34 endoplasmic reticulum calcium ion homeostasis GO:0032469 9.66 BAX BCL2
35 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 IL1B TNF
36 regulation of protein heterodimerization activity GO:0043497 9.65 BAX BCL2
37 extrinsic apoptotic signaling pathway GO:0097191 9.65 BAX FAS TNF
38 response to salt stress GO:0009651 9.64 BAX TNF
39 positive regulation of chemokine biosynthetic process GO:0045080 9.64 IL1B TNF
40 ectopic germ cell programmed cell death GO:0035234 9.63 BAX IL1B
41 cellular response to organic substance GO:0071310 9.63 BAX BCL2 IL1B
42 regulation of establishment of endothelial barrier GO:1903140 9.62 IL1B TNF
43 regulation of protein homodimerization activity GO:0043496 9.62 BAX BCL2
44 ovarian follicle development GO:0001541 9.61 BAX BCL2 VEGFA
45 leukocyte homeostasis GO:0001776 9.6 BAX BCL2
46 necroptotic signaling pathway GO:0097527 9.59 FAS TNF
47 positive regulation of neuroinflammatory response GO:0150078 9.58 IL1B TNF
48 positive regulation of fever generation GO:0031622 9.57 IL1B TNF
49 response to glucocorticoid GO:0051384 9.56 BCL2 TNF
50 sequestering of triglyceride GO:0030730 9.52 IL1B TNF

Molecular functions related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 BAX BCL2 FAS TNF VEGFA
2 cytokine activity GO:0005125 9.33 IL1B TNF VEGFA
3 channel activity GO:0015267 9.26 BAX BCL2
4 BH3 domain binding GO:0051434 8.62 BAX BCL2

Sources for Kashin-Beck Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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