MCID: KSH004
MIFTS: 38

Kashin-Beck Disease

Categories: Bone diseases

Aliases & Classifications for Kashin-Beck Disease

MalaCards integrated aliases for Kashin-Beck Disease:

Name: Kashin-Beck Disease 40 17 71

Classifications:



External Ids:

UMLS 71 C2745963

Summaries for Kashin-Beck Disease

MalaCards based summary : Kashin-Beck Disease is related to osteoarthritis and arthropathy. An important gene associated with Kashin-Beck Disease is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Selenic acid and Protective Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Kashin-Beck disease (KBD) is a chronic, endemic type of osteochondropathy (disease of the bone) that is... more...

Related Diseases for Kashin-Beck Disease

Diseases related to Kashin-Beck Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 osteoarthritis 32.6 TNF IL1B COL2A1
2 arthropathy 30.3 TNF IL1B COL2A1
3 rheumatoid arthritis 29.5 TNF IL1B FAS COL2A1
4 dwarfism 10.7
5 rickets 10.5
6 osteochondrosis 10.5
7 avascular necrosis 10.5
8 soft tissue sarcoma 10.3 TNF BCL2
9 autoimmune disease 10.3
10 osteoporosis 10.3
11 odontochondrodysplasia 10.3
12 ehlers-danlos syndrome, dermatosparaxis type 10.3
13 chudley-mccullough syndrome 10.3
14 body mass index quantitative trait locus 1 10.3
15 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3
16 bone mineral density quantitative trait locus 8 10.3
17 bone mineral density quantitative trait locus 15 10.3
18 keshan disease 10.3
19 brugada syndrome 10.3
20 goiter 10.3
21 dental fluorosis 10.3
22 exostosis 10.3
23 juvenile rheumatoid arthritis 10.3
24 muscular atrophy 10.3
25 cytokine deficiency 10.3
26 posttransplant acute limbic encephalitis 10.3
27 rapidly involuting congenital hemangioma 10.3
28 systemic onset juvenile idiopathic arthritis 10.3 TNF IL1B
29 staphylococcal toxic shock syndrome 10.3 TNF IL1B
30 vulvar vestibulitis syndrome 10.3 TNF IL1B
31 palladium allergic contact dermatitis 10.3 TNF IL1B
32 congenital cytomegalovirus 10.3 TNF IL1B
33 actinic prurigo 10.3 TNF IL1B
34 stachybotrys chartarum 10.3 TNF IL1B
35 eales disease 10.3 TNF IL1B
36 palindromic rheumatism 10.3 TNF IL1B
37 irritant dermatitis 10.3 TNF IL1B
38 idiopathic neutropenia 10.3 TNF IL1B
39 autoimmune vasculitis 10.3 TNF IL1B
40 periapical periodontitis 10.3 TNF IL1B
41 dental pulp disease 10.3 TNF IL1B
42 laryngitis 10.3 TNF IL1B
43 bagassosis 10.3 TNF IL1B
44 paratyphoid fever 10.3 TNF IL1B
45 glossitis 10.3 TNF IL1B
46 cardiac sarcoidosis 10.3 TNF IL1B
47 polyradiculopathy 10.3 TNF IL1B
48 subacute thyroiditis 10.2 TNF IL1B
49 opisthorchiasis 10.2 TNF IL1B
50 burning mouth syndrome 10.2 TNF IL1B

Graphical network of the top 20 diseases related to Kashin-Beck Disease:



Diseases related to Kashin-Beck Disease

Symptoms & Phenotypes for Kashin-Beck Disease

GenomeRNAi Phenotypes related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 BAX BCL2 FAS IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 BAX BCL2 FAS IL1B TNF

MGI Mouse Phenotypes related to Kashin-Beck Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.95 BCL2 COL2A1 FAS IL1B TNF TXNRD2
2 growth/size/body region MP:0005378 9.95 BAX BCL2 COL2A1 DIO2 FAS IL1B
3 homeostasis/metabolism MP:0005376 9.92 BAX BCL2 COL2A1 DIO2 FAS IL1B
4 craniofacial MP:0005382 9.85 BCL2 COL2A1 FAS IL1B TNF
5 digestive/alimentary MP:0005381 9.83 BCL2 COL2A1 DIO2 FAS TNF
6 nervous system MP:0003631 9.7 BAX BCL2 COL2A1 FAS IL1B TNF
7 hearing/vestibular/ear MP:0005377 9.67 BAX BCL2 COL2A1 FAS
8 neoplasm MP:0002006 9.65 BAX BCL2 FAS IL1B TNF
9 renal/urinary system MP:0005367 9.35 BAX BCL2 COL2A1 DIO2 FAS
10 skeleton MP:0005390 9.1 BAX COL2A1 DIO2 FAS IL1B TNF

Drugs & Therapeutics for Kashin-Beck Disease

Drugs for Kashin-Beck Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Selenic acid Approved Phase 2 7783-08-6
2 Protective Agents Phase 2
3 Antioxidants Phase 2
4 Garcinia Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of the Effects of Antioxidant Supplementation in Patients Suffering From Kashin-Beck Disease Unknown status NCT00376025 Phase 2

Search NIH Clinical Center for Kashin-Beck Disease

Genetic Tests for Kashin-Beck Disease

Anatomical Context for Kashin-Beck Disease

MalaCards organs/tissues related to Kashin-Beck Disease:

40
Bone, Thyroid, Liver, Colon, Monocytes, Breast, T Cells

Publications for Kashin-Beck Disease

Articles related to Kashin-Beck Disease:

(show top 50) (show all 332)
# Title Authors PMID Year
1
Serious Selenium Deficiency in the Serum of Patients with Kashin-Beck Disease and the Effect of Nano-Selenium on Their Chondrocytes. 61
31175635 2020
2
Comparison of the toxic mechanism of T-2 toxin and deoxynivalenol on human chondrocytes by microarray and bioinformatics analysis. 61
31863870 2020
3
Screening for differentially expressed circRNA between Kashin-Beck disease and osteoarthritis patients based on circRNA chips. 61
31678276 2020
4
ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease. 61
31734379 2020
5
Relationship of the mobile forms of calcium and strontium in soils with their accumulation in meadow plants in the area of Kashin-Beck endemia. 61
31111334 2020
6
Inhibiting the aberrant activation of Wnt/β-catenin signaling by selenium supplementation ameliorates deoxynivalenol-induced toxicity and catabolism in chondrocytes. 61
31808557 2019
7
Expression and localization of the small proteoglycans decorin and biglycan in articular cartilage of Kashin-Beck disease and rats induced by T-2 toxin and selenium deficiency. 61
31478096 2019
8
Abnormal expression of chondroitin sulfate sulfotransferases in the articular cartilage of pediatric patients with Kashin-Beck disease. 61
31845005 2019
9
The effectiveness of treatments for Kashin-Beck disease: a systematic review and network meta-analysis. 61
31376086 2019
10
[Stepwise treatment for knee lesion of adult Kashin-Beck disease]. 61
31870062 2019
11
DR4-Associated Death Receptor Signal Promotes Cartilage Damage in Patients With Kashin-Beck Disease. 61
31762289 2019
12
Cytotoxic Properties of HT-2 Toxin in Human Chondrocytes: Could T3 Inhibit Toxicity of HT-2? 61
31731600 2019
13
Decreased Expression of CHST-12, CHST-13, and UST in the Proximal Interphalangeal Joint Cartilage of School-Age Children with Kashin-Beck Disease: an Endemic Osteoarthritis in China Caused by Selenium Deficiency. 61
30661165 2019
14
Roles of glycoprotein glycosylation in the pathogenesis and effectiveness evaluation of the sodium hyaluronate treatment of an endemic osteoarthritis Kashin-Beck disease. 61
31655502 2019
15
Association between DIO2 polymorphism and the risk of Kashin-Beck disease in the Tibetan population. 61
31433532 2019
16
The urinary levels of CTX-II, C2C, PYD, and Helix-II increased among adults with KBD: a cross-sectional study. 61
31639015 2019
17
The role of the fibroblast growth factor family in bone-related diseases. 61
31260189 2019
18
Selenium Content and/or T-2 Toxin Contamination of Cereals, Soil, and Children's Hair in Some Areas of Heilongjiang and Gansu Provinces, China. 61
30607701 2019
19
Prevention and control strategies for children Kashin-Beck disease in China: A systematic review and meta-analysis. 61
31490368 2019
20
A preliminary analysis of microRNA profiles in the subchondral bone between Kashin-Beck disease and primary knee osteoarthritis. 61
31062252 2019
21
Endemic Kashin-Beck disease: A food-sourced osteoarthropathy. 61
31548049 2019
22
Conservative tibiotalocalcaneal fusion for partial talar avascular necrosis in conjunction with ankle and subtalar joint osteoarthritis in Kashin-Beck disease: A case report: Erratum. 61
31441903 2019
23
Expression Profiles of Selenium-Related Genes in Human Chondrocytes Exposed to T-2 Toxin and Deoxynivalenol. 61
30406490 2019
24
Conservative tibiotalocalcaneal fusion for partial talar avascular necrosis in conjunction with ankle and subtalar joint osteoarthritis in Kashin-Beck disease: A case report. 61
31335683 2019
25
Hair multi-bioelement profile of Kashin-Beck disease in the endemic regions of China. 61
31109624 2019
26
Genetic variants in the ITPR2 gene are associated with Kashin-Beck Disease in Tibetan. 61
31066235 2019
27
Changes in the NF-κB signaling pathway in juvenile and adult patients with Kashin-Beck disease. 61
30951708 2019
28
Differential gene expression in articular cartilage between rheumatoid arthritis and endemic Kashin-Beck disease. 61
31196963 2019
29
Integrative Analysis of Genome-Wide Association Studies and DNA Methylation Profile Identified Genetic Control Genes of DNA Methylation for Kashin-Beck Disease. 61
31220921 2019
30
Pathway-based network analyses and candidate genes associated with Kashin-Beck disease. 61
31045836 2019
31
Long-term efficacy of repeated sodium hyaluronate injections in adult patients with Kashin-Beck disease of the knee. 61
30460780 2019
32
The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease. 61
29653292 2019
33
The Importance of Se-Related Genes in the Chondrocyte of Kashin-Beck Disease Revealed by Whole Genomic Microarray and Network Analysis. 61
29948913 2019
34
Individual and combined toxicity of T-2 toxin and deoxynivalenol on human C-28/I2 and rat primary chondrocytes. 61
30251759 2019
35
The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016. 61
30764809 2019
36
Outcomes of total knee arthroplasty in the adult Kashin-Beck disease with severe osteoarthritis. 61
29971707 2019
37
The levels of urine CTX-II, C2C, and PYD in children patients with Kashin-Beck disease in Qinghai Province of China. 61
30635000 2019
38
Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China. 61
30719180 2019
39
Imbalance of dietary nutrients and the associated differentially expressed genes and pathways may play important roles in juvenile Kashin-Beck disease. 61
29426639 2018
40
T-2 Toxin Induces Epiphyseal Plate Lesions via Decreased SECISBP2-Mediated Selenoprotein Expression in DA Rats, Exacerbated by Selenium Deficiency. 61
30596260 2018
41
Geochemical valuation and intake of F, As, and Se in coal wastes contaminated areas and their potential impacts on local inhabitants, Shaanxi China. 61
29948537 2018
42
Death of chondrocytes in Kashin-Beck disease: Apoptosis, necrosis or necroptosis? 61
30680829 2018
43
The study of GPX3 methylation in patients with Kashin-Beck Disease and its mechanism in chondrocyte apoptosis. 61
30153510 2018
44
Comparison of bone texture between normal individuals and patients with Kashin-Beck disease from plain radiographs in knee. 61
30504816 2018
45
3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro. 61
30119244 2018
46
Selenium-Related Transcriptional Regulation of Gene Expression. 61
30205557 2018
47
RNA-seq analysis reveals different gene ontologies and pathways in rheumatoid arthritis and Kashin-Beck disease. 61
30256536 2018
48
Changes in osteogenic gene expression in hypertrophic chondrocytes induced by SIN-1. 61
30116317 2018
49
Associations Between Selenium Content in Hair and Kashin-Beck Disease/Keshan Disease in Children in Northwestern China: a Prospective Cohort Study. 61
28983831 2018
50
FGF8 and FGFR3 are up-regulated in hypertrophic chondrocytes: Association with chondrocyte death in deep zone of Kashin-Beck disease. 61
29626475 2018

Variations for Kashin-Beck Disease

Expression for Kashin-Beck Disease

Search GEO for disease gene expression data for Kashin-Beck Disease.

Pathways for Kashin-Beck Disease

Pathways related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 TNF IL1B FAS COL2A1 BCL2 BAX
2
Show member pathways
13.25 TNF IL1B FAS BCL2 BAX
3
Show member pathways
13.05 TXNRD2 TNF IL1B FAS BCL2 BAX
4
Show member pathways
12.96 TNF IL1B FAS BCL2 BAX
5
Show member pathways
12.82 TNF FAS COL2A1 BCL2 BAX
6
Show member pathways
12.8 TNF FAS BCL2 BAX
7
Show member pathways
12.77 TNF IL1B FAS BCL2 BAX
8 12.71 TXNRD2 FAS BCL2 BAX
9
Show member pathways
12.68 TNF FAS BCL2 BAX
10
Show member pathways
12.54 TNF IL1B FAS BCL2 BAX
11 12.49 TNF IL1B FAS BCL2 BAX
12
Show member pathways
12.46 TNF IL1B BCL2 BAX
13
Show member pathways
12.45 TNF IL1B FAS BCL2
14
Show member pathways
12.35 IL1B BCL2 BAX
15
Show member pathways
12.32 IL1B BCL2 BAX
16
Show member pathways
12.26 FAS BCL2 BAX
17 12.26 TNF IL1B BCL2 BAX
18
Show member pathways
12.19 TXNRD2 TNF IL1B DIO2
19
Show member pathways
12.16 TNF IL1B BCL2
20
Show member pathways
12.15 FAS BCL2 BAX
21 12.14 TNF IL1B FAS BAX
22 12.12 TNF IL1B BCL2
23
Show member pathways
12.08 TNF IL1B FAS
24 12.06 TNF FAS BCL2 BAX
25 12.01 TNF IL1B BCL2 BAX
26 11.99 TNF IL1B BCL2
27 11.96 FAS BCL2 BAX
28
Show member pathways
11.93 TNF BCL2 BAX
29 11.91 TNF IL1B COL2A1
30 11.91 TNF BCL2 BAX
31 11.88 TNF IL1B BCL2
32
Show member pathways
11.88 TNF BCL2 BAX
33
Show member pathways
11.88 TNF FAS BCL2 BAX
34 11.87 TNF IL1B FAS
35 11.82 TNF IL1B BCL2
36
Show member pathways
11.71 FAS BCL2 BAX
37 11.64 FAS BCL2 BAX
38 11.46 TNF IL1B BCL2 BAX
39 11.42 TNF IL1B BAX
40 11.37 TNF BCL2 BAX
41
Show member pathways
11.36 TNF IL1B
42
Show member pathways
11.33 FAS BCL2 BAX
43 11.27 IL1B BAX
44 11.26 TNF IL1B
45
Show member pathways
11.26 TNF IL1B FAS BCL2 BAX
46 11.22 TNF IL1B
47 11.22 TNF IL1B FAS
48 11.21 TNF IL1B
49 11.17 TNF IL1B
50 11.16 BCL2 BAX

GO Terms for Kashin-Beck Disease

Cellular components related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pore complex GO:0046930 8.62 BCL2 BAX

Biological processes related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.98 IL1B FAS BCL2 BAX
2 cytokine-mediated signaling pathway GO:0019221 9.89 TNF IL1B BCL2
3 regulation of apoptotic process GO:0042981 9.88 FAS BCL2 BAX
4 positive regulation of protein phosphorylation GO:0001934 9.83 TNF IL1B FAS
5 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.75 TNF FAS BAX
6 neuron apoptotic process GO:0051402 9.71 BCL2 BAX
7 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.71 BCL2 BAX
8 protein kinase B signaling GO:0043491 9.7 TNF IL1B
9 ovarian follicle development GO:0001541 9.7 BCL2 BAX
10 negative regulation of mitotic cell cycle GO:0045930 9.7 TNF BCL2
11 positive regulation of interleukin-6 secretion GO:2000778 9.7 TNF IL1B
12 lipopolysaccharide-mediated signaling pathway GO:0031663 9.69 TNF IL1B
13 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 9.69 BCL2 BAX
14 negative regulation of apoptotic signaling pathway GO:2001234 9.69 BCL2 BAX
15 homeostasis of number of cells within a tissue GO:0048873 9.68 BCL2 BAX
16 regulation of mitochondrial membrane potential GO:0051881 9.68 BCL2 BAX
17 negative regulation of neurogenesis GO:0050768 9.68 TNF IL1B
18 positive regulation of interleukin-8 production GO:0032757 9.67 TNF IL1B
19 response to gamma radiation GO:0010332 9.67 BCL2 BAX
20 limb morphogenesis GO:0035108 9.67 COL2A1 BAX
21 apoptotic signaling pathway GO:0097190 9.67 TNF FAS BAX
22 release of cytochrome c from mitochondria GO:0001836 9.66 BCL2 BAX
23 B cell homeostasis GO:0001782 9.65 BCL2 BAX
24 apoptotic mitochondrial changes GO:0008637 9.65 BCL2 BAX
25 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.65 TNF IL1B
26 positive regulation of glial cell proliferation GO:0060252 9.64 TNF IL1B
27 negative regulation of lipid catabolic process GO:0050995 9.64 TNF IL1B
28 astrocyte activation GO:0048143 9.63 TNF IL1B
29 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 TNF IL1B
30 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.63 TNF BCL2 BAX
31 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 TNF IL1B
32 endoplasmic reticulum calcium ion homeostasis GO:0032469 9.62 BCL2 BAX
33 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.61 TNF IL1B
34 positive regulation of neuroinflammatory response GO:0150078 9.61 TNF IL1B
35 positive regulation of chemokine biosynthetic process GO:0045080 9.6 TNF IL1B
36 response to salt stress GO:0009651 9.59 TNF BAX
37 regulation of protein heterodimerization activity GO:0043497 9.58 BCL2 BAX
38 extrinsic apoptotic signaling pathway GO:0097191 9.58 TNF FAS BAX
39 regulation of establishment of endothelial barrier GO:1903140 9.57 TNF IL1B
40 ectopic germ cell programmed cell death GO:0035234 9.56 IL1B BAX
41 necroptotic signaling pathway GO:0097527 9.55 TNF FAS
42 leukocyte homeostasis GO:0001776 9.54 BCL2 BAX
43 regulation of protein homodimerization activity GO:0043496 9.52 BCL2 BAX
44 positive regulation of fever generation GO:0031622 9.51 TNF IL1B
45 sequestering of triglyceride GO:0030730 9.48 TNF IL1B
46 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 TNF IL1B
47 cellular response to organic substance GO:0071310 9.43 IL1B BCL2 BAX
48 positive regulation of developmental pigmentation GO:0048087 9.37 BCL2 BAX
49 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.33 TNF BCL2 BAX
50 regulation of nitrogen utilization GO:0006808 9.32 BCL2 BAX

Molecular functions related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 TNF FAS COL2A1 BCL2 BAX
2 channel activity GO:0015267 9.16 BCL2 BAX
3 BH3 domain binding GO:0051434 8.62 BCL2 BAX

Sources for Kashin-Beck Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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