MCID: KSH004
MIFTS: 38

Kashin-Beck Disease

Categories: Bone diseases

Aliases & Classifications for Kashin-Beck Disease

MalaCards integrated aliases for Kashin-Beck Disease:

Name: Kashin-Beck Disease 40 17 71

Classifications:



External Ids:

UMLS 71 C2745963

Summaries for Kashin-Beck Disease

MalaCards based summary : Kashin-Beck Disease is related to osteoarthritis and arthropathy. An important gene associated with Kashin-Beck Disease is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Selenic acid and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and brain, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Kashin-Beck disease (KBD) is a chronic, endemic type of osteochondropathy (disease of the bone) that is... more...

Related Diseases for Kashin-Beck Disease

Diseases related to Kashin-Beck Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 osteoarthritis 32.5 TNF IL1B COL2A1
2 arthropathy 30.4 TNF IL1B COL2A1
3 dwarfism 10.7
4 rheumatoid arthritis 10.6
5 rickets 10.5
6 osteochondrosis 10.5
7 avascular necrosis 10.5
8 soft tissue sarcoma 10.3 TNF BCL2
9 autoimmune disease 10.3
10 osteoporosis 10.3
11 odontochondrodysplasia 10.3
12 ehlers-danlos syndrome, dermatosparaxis type 10.3
13 spondylometaphyseal dysplasia, sedaghatian type 10.3
14 chudley-mccullough syndrome 10.3
15 body mass index quantitative trait locus 1 10.3
16 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3
17 bone mineral density quantitative trait locus 8 10.3
18 bone mineral density quantitative trait locus 15 10.3
19 keshan disease 10.3
20 brugada syndrome 10.3
21 goiter 10.3
22 dental fluorosis 10.3
23 exostosis 10.3
24 juvenile rheumatoid arthritis 10.3
25 muscular atrophy 10.3
26 posttransplant acute limbic encephalitis 10.3
27 rapidly involuting congenital hemangioma 10.3
28 physiological polycythemia 10.3 TNF IL1B
29 systemic onset juvenile idiopathic arthritis 10.3 TNF IL1B
30 staphylococcal toxic shock syndrome 10.3 TNF IL1B
31 vulvar vestibulitis syndrome 10.3 TNF IL1B
32 palladium allergic contact dermatitis 10.3 TNF IL1B
33 congenital cytomegalovirus 10.3 TNF IL1B
34 anaerobic pneumonia 10.3 TNF IL1B
35 jejunoileitis 10.3 TNF IL1B
36 metal allergy 10.3 TNF IL1B
37 actinic prurigo 10.3 TNF IL1B
38 stachybotrys chartarum 10.3 TNF IL1B
39 eales disease 10.3 TNF IL1B
40 carbuncle 10.3 TNF IL1B
41 chemical colitis 10.3 TNF IL1B
42 aortitis 10.3 TNF IL1B
43 palindromic rheumatism 10.3 TNF IL1B
44 anthracosis 10.3 TNF IL1B
45 pneumonic tularemia 10.3 TNF IL1B
46 tularemia 10.3 TNF IL1B
47 lung abscess 10.3 TNF IL1B
48 chlamydia pneumonia 10.3 TNF IL1B
49 lumbosacral lipoma 10.3 TNF IL1B
50 peptic esophagitis 10.3 TNF IL1B

Graphical network of the top 20 diseases related to Kashin-Beck Disease:



Diseases related to Kashin-Beck Disease

Symptoms & Phenotypes for Kashin-Beck Disease

GenomeRNAi Phenotypes related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.23 FAS IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.23 BAX FAS IL1B TNF
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.23 BAX

MGI Mouse Phenotypes related to Kashin-Beck Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 BAX BCL2 COL2A1 DIO2 FAS IL1B
2 cardiovascular system MP:0005385 9.95 BCL2 COL2A1 FAS IL1B TNF TXNRD2
3 growth/size/body region MP:0005378 9.95 BAX BCL2 COL2A1 DIO2 FAS IL1B
4 craniofacial MP:0005382 9.85 BCL2 COL2A1 FAS IL1B TNF
5 digestive/alimentary MP:0005381 9.83 BCL2 COL2A1 DIO2 FAS TNF
6 muscle MP:0005369 9.72 BAX BCL2 FAS TNF TXNRD2
7 nervous system MP:0003631 9.7 BAX BCL2 COL2A1 FAS IL1B TNF
8 neoplasm MP:0002006 9.65 BAX BCL2 FAS IL1B TNF
9 renal/urinary system MP:0005367 9.35 BAX BCL2 COL2A1 DIO2 FAS
10 skeleton MP:0005390 9.1 BAX COL2A1 DIO2 FAS IL1B TNF

Drugs & Therapeutics for Kashin-Beck Disease

Drugs for Kashin-Beck Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Selenic acid Approved Phase 2 7783-08-6
2 Antioxidants Phase 2
3 Protective Agents Phase 2
4 Garcinia Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of the Effects of Antioxidant Supplementation in Patients Suffering From Kashin-Beck Disease Unknown status NCT00376025 Phase 2

Search NIH Clinical Center for Kashin-Beck Disease

Genetic Tests for Kashin-Beck Disease

Anatomical Context for Kashin-Beck Disease

MalaCards organs/tissues related to Kashin-Beck Disease:

40
Bone, Testes, Brain, Heart, Colon, Thyroid, Monocytes

Publications for Kashin-Beck Disease

Articles related to Kashin-Beck Disease:

(show top 50) (show all 337)
# Title Authors PMID Year
1
Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease. 61
32517548 2020
2
Effects of methylation of deiodinase 3 gene on gene expression and severity of Kashin-Beck disease. 61
32458485 2020
3
Inhibiting the aberrant activation of Wnt/β-catenin signaling by selenium supplementation ameliorates deoxynivalenol-induced toxicity and catabolism in chondrocytes. 61
31808557 2020
4
Endemic Kashin-Beck disease: A food-sourced osteoarthropathy. 61
31548049 2020
5
Proteomic analysis of knee cartilage reveals potential signaling pathways in pathological mechanism of Kashin-Beck disease compared with osteoarthritis. 61
32322000 2020
6
Comparison of the responsiveness of the WOMAC and the 12-item WHODAS 2.0 in patients with Kashin-Beck disease. 61
32213176 2020
7
Abnormal expression of chondroitin sulfate sulfotransferases in the articular cartilage of pediatric patients with Kashin-Beck disease. 61
31845005 2020
8
Serious Selenium Deficiency in the Serum of Patients with Kashin-Beck Disease and the Effect of Nano-Selenium on Their Chondrocytes. 61
31175635 2020
9
A comparative study of clinical effect of total knee arthroplasty in the treatment of primary osteoarthritis and osteoarthritis of Kashin-Beck disease. 61
32232536 2020
10
Comparison of the toxic mechanism of T-2 toxin and deoxynivalenol on human chondrocytes by microarray and bioinformatics analysis. 61
31863870 2020
11
ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease. 61
31734379 2020
12
Screening for differentially expressed circRNA between Kashin-Beck disease and osteoarthritis patients based on circRNA chips. 61
31678276 2020
13
Relationship of the mobile forms of calcium and strontium in soils with their accumulation in meadow plants in the area of Kashin-Beck endemia. 61
31111334 2020
14
The effectiveness of treatments for Kashin-Beck disease: a systematic review and network meta-analysis. 61
31376086 2019
15
[Stepwise treatment for knee lesion of adult Kashin-Beck disease]. 61
31870062 2019
16
Expression and localization of the small proteoglycans decorin and biglycan in articular cartilage of Kashin-Beck disease and rats induced by T-2 toxin and selenium deficiency. 61
31478096 2019
17
Cytotoxic Properties of HT-2 Toxin in Human Chondrocytes: Could T3 Inhibit Toxicity of HT-2? 61
31731600 2019
18
DR4-Associated Death Receptor Signal Promotes Cartilage Damage in Patients With Kashin-Beck Disease. 61
31762289 2019
19
Association between DIO2 polymorphism and the risk of Kashin-Beck disease in the Tibetan population. 61
31433532 2019
20
The urinary levels of CTX-II, C2C, PYD, and Helix-II increased among adults with KBD: a cross-sectional study. 61
31639015 2019
21
The role of the fibroblast growth factor family in bone-related diseases. 61
31260189 2019
22
Decreased Expression of CHST-12, CHST-13, and UST in the Proximal Interphalangeal Joint Cartilage of School-Age Children with Kashin-Beck Disease: an Endemic Osteoarthritis in China Caused by Selenium Deficiency. 61
30661165 2019
23
Roles of glycoprotein glycosylation in the pathogenesis and effectiveness evaluation of the sodium hyaluronate treatment of an endemic osteoarthritis Kashin-Beck disease. 61
31655502 2019
24
Selenium Content and/or T-2 Toxin Contamination of Cereals, Soil, and Children's Hair in Some Areas of Heilongjiang and Gansu Provinces, China. 61
30607701 2019
25
A preliminary analysis of microRNA profiles in the subchondral bone between Kashin-Beck disease and primary knee osteoarthritis. 61
31062252 2019
26
Prevention and control strategies for children Kashin-Beck disease in China: A systematic review and meta-analysis. 61
31490368 2019
27
Conservative tibiotalocalcaneal fusion for partial talar avascular necrosis in conjunction with ankle and subtalar joint osteoarthritis in Kashin-Beck disease: A case report: Erratum. 61
31441903 2019
28
Expression Profiles of Selenium-Related Genes in Human Chondrocytes Exposed to T-2 Toxin and Deoxynivalenol. 61
30406490 2019
29
Conservative tibiotalocalcaneal fusion for partial talar avascular necrosis in conjunction with ankle and subtalar joint osteoarthritis in Kashin-Beck disease: A case report. 61
31335683 2019
30
Genetic variants in the ITPR2 gene are associated with Kashin-Beck Disease in Tibetan. 61
31066235 2019
31
Hair multi-bioelement profile of Kashin-Beck disease in the endemic regions of China. 61
31109624 2019
32
Changes in the NF-κB signaling pathway in juvenile and adult patients with Kashin-Beck disease. 61
30951708 2019
33
Differential gene expression in articular cartilage between rheumatoid arthritis and endemic Kashin-Beck disease. 61
31196963 2019
34
Integrative Analysis of Genome-Wide Association Studies and DNA Methylation Profile Identified Genetic Control Genes of DNA Methylation for Kashin-Beck Disease. 61
31220921 2019
35
Pathway-based network analyses and candidate genes associated with Kashin-Beck disease. 61
31045836 2019
36
Long-term efficacy of repeated sodium hyaluronate injections in adult patients with Kashin-Beck disease of the knee. 61
30460780 2019
37
The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease. 61
29653292 2019
38
The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016. 61
30764809 2019
39
The Importance of Se-Related Genes in the Chondrocyte of Kashin-Beck Disease Revealed by Whole Genomic Microarray and Network Analysis. 61
29948913 2019
40
Outcomes of total knee arthroplasty in the adult Kashin-Beck disease with severe osteoarthritis. 61
29971707 2019
41
Individual and combined toxicity of T-2 toxin and deoxynivalenol on human C-28/I2 and rat primary chondrocytes. 61
30251759 2019
42
The levels of urine CTX-II, C2C, and PYD in children patients with Kashin-Beck disease in Qinghai Province of China. 61
30635000 2019
43
Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China. 61
30719180 2019
44
Imbalance of dietary nutrients and the associated differentially expressed genes and pathways may play important roles in juvenile Kashin-Beck disease. 61
29426639 2018
45
Geochemical valuation and intake of F, As, and Se in coal wastes contaminated areas and their potential impacts on local inhabitants, Shaanxi China. 61
29948537 2018
46
The study of GPX3 methylation in patients with Kashin-Beck Disease and its mechanism in chondrocyte apoptosis. 61
30153510 2018
47
Death of chondrocytes in Kashin-Beck disease: Apoptosis, necrosis or necroptosis? 61
30680829 2018
48
T-2 Toxin Induces Epiphyseal Plate Lesions via Decreased SECISBP2-Mediated Selenoprotein Expression in DA Rats, Exacerbated by Selenium Deficiency. 61
30596260 2018
49
Comparison of bone texture between normal individuals and patients with Kashin-Beck disease from plain radiographs in knee. 61
30504816 2018
50
3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro. 61
30119244 2018

Variations for Kashin-Beck Disease

Expression for Kashin-Beck Disease

Search GEO for disease gene expression data for Kashin-Beck Disease.

Pathways for Kashin-Beck Disease

Pathways related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.64 TNF IL1B FAS COL2A1 BCL2 BAX
2
Show member pathways
13.26 TNF IL1B FAS BCL2 BAX
3
Show member pathways
13.08 TXNRD2 TNF IL1B FAS BCL2 BAX
4
Show member pathways
12.9 TNF IL1B FAS BCL2 BAX
5
Show member pathways
12.84 TNF FAS COL2A1 BCL2 BAX
6
Show member pathways
12.79 TNF IL1B FAS BCL2 BAX
7 12.72 TXNRD2 FAS BCL2 BAX
8
Show member pathways
12.58 TNF FAS BCL2 BAX
9
Show member pathways
12.56 TNF IL1B FAS BCL2 BAX
10 12.49 TNF IL1B FAS BCL2 BAX
11
Show member pathways
12.47 TNF IL1B BCL2 BAX
12
Show member pathways
12.47 TNF IL1B FAS BCL2
13
Show member pathways
12.33 IL1B BCL2 BAX
14 12.28 TNF IL1B BCL2 BAX
15
Show member pathways
12.27 FAS BCL2 BAX
16
Show member pathways
12.21 TXNRD2 TNF IL1B DIO2
17 12.17 TNF IL1B BCL2 BAX
18
Show member pathways
12.16 TNF IL1B BCL2
19
Show member pathways
12.15 FAS BCL2 BAX
20 12.13 TNF IL1B BCL2
21 12.11 TNF IL1B FAS BAX
22
Show member pathways
12.09 TNF IL1B FAS
23 12.08 TNF FAS BCL2 BAX
24 12.03 TNF IL1B FAS
25 12.03 TNF IL1B BCL2 BAX
26 12 TNF IL1B BCL2
27 11.97 FAS BCL2 BAX
28
Show member pathways
11.94 TNF BCL2 BAX
29 11.92 TNF IL1B COL2A1
30 11.92 TNF BCL2 BAX
31 11.9 TNF IL1B BCL2
32 11.88 TNF IL1B FAS
33
Show member pathways
11.88 TNF FAS BCL2 BAX
34 11.84 TNF IL1B BCL2
35 11.8 TNF BCL2 BAX
36
Show member pathways
11.72 FAS BCL2 BAX
37 11.66 FAS BCL2 BAX
38 11.46 TNF IL1B BCL2 BAX
39 11.44 TNF IL1B BAX
40 11.39 TNF BCL2 BAX
41
Show member pathways
11.34 FAS BCL2 BAX
42 11.27 IL1B BAX
43 11.27 TNF IL1B
44
Show member pathways
11.25 TNF IL1B FAS BCL2 BAX
45 11.24 TNF IL1B FAS
46 11.23 TNF IL1B
47 11.21 TNF IL1B
48 11.18 TNF IL1B
49
Show member pathways
11.17 TNF FAS BCL2
50 11.16 BCL2 BAX

GO Terms for Kashin-Beck Disease

Cellular components related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pore complex GO:0046930 8.62 BCL2 BAX

Biological processes related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.96 IL1B FAS BCL2 BAX
2 regulation of apoptotic process GO:0042981 9.87 FAS BCL2 BAX
3 positive regulation of protein phosphorylation GO:0001934 9.83 TNF IL1B FAS
4 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.73 TNF FAS BAX
5 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.7 BCL2 BAX
6 apoptotic signaling pathway GO:0097190 9.7 TNF FAS BAX
7 protein kinase B signaling GO:0043491 9.69 TNF IL1B
8 negative regulation of mitotic cell cycle GO:0045930 9.69 TNF BCL2
9 lipopolysaccharide-mediated signaling pathway GO:0031663 9.69 TNF IL1B
10 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 9.68 BCL2 BAX
11 homeostasis of number of cells within a tissue GO:0048873 9.68 BCL2 BAX
12 regulation of mitochondrial membrane potential GO:0051881 9.68 BCL2 BAX
13 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 TNF IL1B
14 positive regulation of interleukin-8 production GO:0032757 9.67 TNF IL1B
15 negative regulation of neurogenesis GO:0050768 9.67 TNF IL1B
16 response to gamma radiation GO:0010332 9.67 BCL2 BAX
17 limb morphogenesis GO:0035108 9.66 COL2A1 BAX
18 release of cytochrome c from mitochondria GO:0001836 9.65 BCL2 BAX
19 B cell homeostasis GO:0001782 9.65 BCL2 BAX
20 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.65 TNF BCL2 BAX
21 positive regulation of glial cell proliferation GO:0060252 9.64 TNF IL1B
22 apoptotic mitochondrial changes GO:0008637 9.64 BCL2 BAX
23 negative regulation of lipid catabolic process GO:0050995 9.63 TNF IL1B
24 astrocyte activation GO:0048143 9.63 TNF IL1B
25 endoplasmic reticulum calcium ion homeostasis GO:0032469 9.62 BCL2 BAX
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 TNF IL1B
27 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.61 TNF IL1B
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 TNF IL1B
29 extrinsic apoptotic signaling pathway GO:0097191 9.61 TNF FAS BAX
30 positive regulation of chemokine biosynthetic process GO:0045080 9.6 TNF IL1B
31 positive regulation of neuroinflammatory response GO:0150078 9.59 TNF IL1B
32 response to salt stress GO:0009651 9.58 TNF BAX
33 regulation of establishment of endothelial barrier GO:1903140 9.58 TNF IL1B
34 necroptotic signaling pathway GO:0097527 9.57 TNF FAS
35 ectopic germ cell programmed cell death GO:0035234 9.55 IL1B BAX
36 leukocyte homeostasis GO:0001776 9.54 BCL2 BAX
37 positive regulation of fever generation GO:0031622 9.51 TNF IL1B
38 cellular response to organic substance GO:0071310 9.5 IL1B BCL2 BAX
39 sequestering of triglyceride GO:0030730 9.49 TNF IL1B
40 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 TNF IL1B
41 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.43 TNF BCL2 BAX
42 positive regulation of developmental pigmentation GO:0048087 9.4 BCL2 BAX
43 regulation of nitrogen utilization GO:0006808 9.37 BCL2 BAX
44 negative regulation of apoptotic signaling pathway GO:2001234 9.33 TNF BCL2 BAX
45 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.26 TNF IL1B COL2A1 BCL2
46 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 8.92 IL1B FAS BCL2 BAX

Molecular functions related to Kashin-Beck Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 TNF FAS COL2A1 BCL2 BAX
2 channel activity GO:0015267 9.16 BCL2 BAX
3 BH3 domain binding GO:0051434 8.62 BCL2 BAX

Sources for Kashin-Beck Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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