Aliases & Classifications for Keloids

MalaCards integrated aliases for Keloids:

Name: Keloids 38 76
Keloid Disorder 76
Keloid 55

Summaries for Keloids

MalaCards based summary : Keloids, also known as keloid disorder, is related to hypertrophic scars and localized scleroderma. An important gene associated with Keloids is H19 (H19, Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Integrin Pathway and Toll-like Receptor Signaling Pathway. The drugs Fluorouracil and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and endothelial, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 76 Keloid, also known as keloid disorder and keloidal scar, is the formation of a type of scar which,... more...

Related Diseases for Keloids

Diseases related to Keloids via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 hypertrophic scars 32.1 CD36 SMAD2 SMAD3 TGFB1 TGFB3
2 localized scleroderma 30.2 MMP1 SMAD3 TGFB1
3 gingival overgrowth 29.6 CD36 MMP1 TGFB1
4 nephrogenic systemic fibrosis 29.5 SMAD2 SMAD3 SMAD7 TGFB1
5 keloid formation 12.6
6 torticollis, keloids, cryptorchidism, and renal dysplasia 12.5
7 x-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome 12.0
8 premature aging syndrome, penttinen type 11.4
9 lobomycosis 11.4
10 frontometaphyseal dysplasia 2 11.0
11 desmoid tumor 11.0
12 trueb burg bottani syndrome 11.0
13 chromosome 16p13.3 deletion syndrome, proximal 10.2
14 autosomal recessive cutis laxa type i 10.2 SMAD2 TGFB1
15 penile disease 10.2 SMAD2 TGFB1
16 blastomycosis 10.1
17 osteochondrosis 10.1 CD36 TGFB1
18 spastic paraplegia 3, autosomal dominant 10.1 SMAD2 TGFB1
19 burn scar 10.1 FAS TGFB1
20 odontogenic myxoma 10.1 CD36 MMP1
21 gingival disease 10.1 MMP1 TGFB1
22 lattice corneal dystrophy 10.1 FAS TGFB1
23 pustulosis palmaris et plantaris 10.1 SMAD7 TGFB1
24 newcastle disease 10.1 CD36 TGFB1
25 recessive dystrophic epidermolysis bullosa 10.1 MMP1 TGFB1
26 peyronie disease 10.1 TGFB1 TGFB3
27 osteofibrous dysplasia 10.1 CD36 TGFB1
28 kashin-beck disease 10.1 FAS MMP1
29 epithelial basement membrane dystrophy 10.1 FAS TGFB1
30 obstructive nephropathy 10.1 SMAD2 SMAD3 TGFB1
31 tuberculoid leprosy 10.1 TGFB1 TGFB3
32 loeys-dietz syndrome 4 10.1 SMAD3 TGFB3
33 ocular cicatricial pemphigoid 10.1 CD36 TGFB1
34 pulmonary fibrosis 10.0 SMAD3 SMAD7 TGFB1
35 fibromatosis, gingival, 1 10.0 CD36 MMP1 TGFB1
36 gingival fibromatosis 10.0 CD36 MMP1 TGFB1
37 basal cell carcinoma 1 10.0
38 burns 10.0
39 basal cell carcinoma 10.0
40 dermatitis 10.0
41 spondylocarpotarsal synostosis syndrome 10.0 SMAD2 SMAD3
42 interstitial keratitis 10.0 CD36 TNC
43 osteoarthritis 10.0 H19 MMP1 TGFB1
44 bethlem myopathy 1 10.0
45 pemphigus vulgaris, familial 10.0
46 insulin-like growth factor i 10.0
47 dermatofibrosarcoma protuberans 10.0
48 pemphigus vulgaris 10.0
49 systemic scleroderma 10.0
50 myopathy 10.0

Graphical network of the top 20 diseases related to Keloids:



Diseases related to Keloids

Symptoms & Phenotypes for Keloids

MGI Mouse Phenotypes related to Keloids:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.14 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
2 cardiovascular system MP:0005385 10.07 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
3 homeostasis/metabolism MP:0005376 10.06 CD36 FAS MMP1 SMAD2 SMAD3 SMAD7
4 cellular MP:0005384 10.05 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
5 digestive/alimentary MP:0005381 10.02 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
6 hematopoietic system MP:0005397 9.98 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
7 craniofacial MP:0005382 9.97 FAS SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
8 immune system MP:0005387 9.97 CD36 FAS MMP1 SMAD2 SMAD3 SMAD7
9 endocrine/exocrine gland MP:0005379 9.93 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
10 liver/biliary system MP:0005370 9.72 CD36 FAS SMAD2 SMAD3 TGFB1
11 nervous system MP:0003631 9.7 CD36 FAS SMAD2 SMAD3 TGFB1 TGFB3
12 neoplasm MP:0002006 9.65 FAS MMP1 SMAD2 SMAD3 TGFB1
13 skeleton MP:0005390 9.43 CD36 FAS SMAD2 SMAD3 TGFB1 TGFB3
14 vision/eye MP:0005391 9.1 CD36 FAS SMAD2 SMAD3 TGFB1 TGFB3

Drugs & Therapeutics for Keloids

Drugs for Keloids (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 110)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 4,Phase 2 51-21-8 3385
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 124-94-7 31307
3
Povidone-iodine Approved Phase 4 25655-41-8
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
6
Tocopherol Approved, Investigational Phase 4 1406-66-2 14986
7
Ethanol Approved Phase 4 64-17-5 702
8
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
9
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
10
Petrolatum Approved, Investigational Phase 4 8009-03-8
11
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
12
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
13
Tetracaine Approved, Vet_approved Phase 4,Not Applicable 94-24-6 5411
14
Prilocaine Approved Phase 4 721-50-6 4906
15
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
16
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
17
Morphine Approved, Investigational Phase 4 57-27-2 5288826
18
Verapamil Approved Phase 4 52-53-9 2520
19
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
20 Tocotrienol Investigational Phase 4 6829-55-6
21 triamcinolone acetonide Phase 4,Phase 3,Phase 1,Not Applicable
22 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 1,Not Applicable
23 Antimetabolites, Antineoplastic Phase 4,Phase 2
24 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Hormone Antagonists Phase 4,Phase 3,Phase 1,Not Applicable
26 glucocorticoids Phase 4,Phase 3,Phase 1,Not Applicable
27 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1,Not Applicable
28 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Hormones Phase 4,Phase 3,Phase 1,Not Applicable
30 Antimetabolites Phase 4,Phase 2
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Not Applicable
32 Triamcinolone diacetate Phase 4,Phase 3,Phase 1,Not Applicable
33 Anesthetics Phase 4,Not Applicable
34 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
35 Emollients Phase 4,Phase 3
36 Calcium, Dietary Phase 4,Phase 1
37 BB 1101 Phase 4
38 Antineoplastic Agents, Hormonal Phase 4
39 Autonomic Agents Phase 4
40 HIV Protease Inhibitors Phase 4
41 Gastrointestinal Agents Phase 4,Not Applicable
42 Antiemetics Phase 4
43 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
44
protease inhibitors Phase 4
45 Protective Agents Phase 4
46 Tocopherols Phase 4
47 Hydrocortisone-17-butyrate Phase 4
48 Tocotrienols Phase 4
49 Micronutrients Phase 4,Phase 2
50 Central Nervous System Depressants Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 97)
# Name Status NCT ID Phase Drugs
1 Pilot Study to Evaluate Clinical Outcomes With the Use of Biovance Following Keloid Scar Revision Surgery Unknown status NCT02521402 Phase 4
2 Keloid Scarring: Treatment and Pathophysiology Unknown status NCT01295099 Phase 4 5- fluorouracil;Triamcinolone
3 A Randomized Clinical Study Comparing Two Closure Techniques of Excised Keloids Unknown status NCT00519493 Phase 4
4 Surgical Excision and Intralesional Steroid Injection for Prevention of Post Caesarean Keloid Recurrence Completed NCT03239964 Phase 4 Dexamethasone
5 A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars Completed NCT00754247 Phase 4 0.5% hydrocortisone, silicone, vitamin E lotion;Onion extract gel;Cetearyl alcohol lotion
6 Effect of Transparent, Self-drying Silicone Gel on the Treatment of Hypertrophic Abdominal Scars Completed NCT01078428 Phase 4
7 Radiesse® Injectable Dermal Filler for the Treatment of Nasolabial Folds in Persons of Color Completed NCT01012388 Phase 4
8 Treatment of Keloidscars With Intralesional Triamcinolone and 5-fluorouracil Injections-prospective, Randomized, Controlled Trial - Pilot Study Completed NCT02155439 Phase 4 5-fluorouracil;Triamcinolone
9 A Post-Market Study to Evaluate Adverse Event Incidence Rates in Patients With Skin of Color Undergoing Correction of Nasolabial Folds With Hylaform, Hylaform Plus and Captique. Completed NCT00293163 Phase 4
10 Pilot Study of a Novel 532nm KTP Laser for the Treatment of Fresh Surgical Scars Completed NCT01789346 Phase 4
11 Effect of Silicone Gel Versus Contractubex Phonophoresis for Post-burn Hypertrophic Scars Completed NCT03777891 Phase 4
12 Post Market Safety Study and Effectiveness With Evolence in Subjects With Skin Color Types IV-VI Completed NCT00891774 Phase 4
13 7% Lidocaine/7% Tetracaine Cream Versus 2,5% Lidocaine / 2,5% Prilocaine Cream Completed NCT02372786 Phase 4 2,5% lidocaine / 2,5% prilocaine cream;7% lidocaine / 7% tetracaine cream
14 The Efficacy of Laser Assisted Hair Removal in the Treatment of Acne Keloidalis Nuchae; a Pilot Study Completed NCT01548898 Phase 4
15 Facial Lipoatrophy Correction Experience With SCULPTRA ("FACES" Study) Completed NCT00360932 Phase 4
16 Use of On-Q Pump for Pain Post C-Section Enrolling by invitation NCT02579629 Phase 4 Ropivacaine 0.1%;Ropivacaine 0.2%;Normal saline
17 Pain Outcomes Following Intralesional Corticosteroid Injections Not yet recruiting NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
18 Verapamil vs Steroid to Prevent Keloid Recurrence Terminated NCT01720056 Phase 4 Verapamil;Kenalog 10
19 Safety and Efficacy of Infrared Diode Laser on Improvement of Scar and Prevention of Recurrence of Excised Keloid Unknown status NCT01158196 Phase 3
20 Scars After Central Venous Catheters Unknown status NCT01113125 Phase 3 Betamethason-17-valerate and fusidic acid;Fusidic Acid
21 Silicone Gel Versus Onion Extract Gel as Prevention for Postsurgical Scars Unknown status NCT01861119 Phase 3 Silicone gel Kelo-cort™;;Onion extract gel Contractubex™
22 CICATRIX in the Treatment of Hypertrophic Scars and Keloids Scars Completed NCT00993005 Phase 3
23 Efficacy of Intralesional Triamcinolone and 8% Topical Pirfenidone for Treatment of Keloid Scars Recruiting NCT02823236 Phase 3 Topical Pirfenidone;Triamcinolone + Pirfenidone;Intralesional Triamcinolone
24 PRP Use in Diabetic Patients Undergoing Cesarean Section Not yet recruiting NCT03602950 Phase 2, Phase 3
25 A Study to Evaluate the Effectiveness and Safety of RXI-109 on the Outcome of Keloid Excision Surgery in Healthy Adults Completed NCT02079168 Phase 2 RXI-109;Placebo
26 Exploratory Study of the Efficacy and Safety of Juvista 250ng When Administered Following Excision of Ear Lobe Keloids Completed NCT00836147 Phase 1, Phase 2 Avotermin (Juvista);Placebo
27 A Pilot Study of Apligraf for the Treatment and Prevention of Recurrence of Excised Keloids Completed NCT00587587 Phase 1, Phase 2
28 Evaluation of the Initial Safety and Efficacy of Keloid Lesions Treated With MF-4181 Completed NCT01446770 Phase 2
29 Trial of Juvista (Avotermin) Following Removal of Ear Lobe Keloid Scars Completed NCT00469235 Phase 1, Phase 2 Avotermin
30 Safety of Juvista When Administered Following Excision of Ear Lobe Keloids Completed NCT00710333 Phase 1, Phase 2 Avotermin;placebo
31 A Study to Evaluate the Safety and Efficacy of AZX100 Drug Product Following Excision of Keloid Scars Completed NCT00825916 Phase 2 AZX100 Drug Product;AZX100 Drug Product;Placebo
32 A Study to Evaluate the Safety and Efficacy of Additional Doses of AZX100 Drug Product Following Excision of Keloid Scars Completed NCT00892723 Phase 2 AZX100 Drug Product;Placebo;AZX100 Drug Product
33 Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix Completed NCT00129428 Phase 1, Phase 2
34 Study of GBT009 for Treatment of Incisional Wounds Following Breast Reconstruction Surgery Completed NCT01053897 Phase 2
35 Efficacy, Safety, and Tolerability of MRG-201 Following Intradermal Injection in Subjects With a History of Keloids Recruiting NCT03601052 Phase 2 MRG-201;Placebo
36 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts Recruiting NCT02705352 Phase 2 5-Fluorouracil
37 Imiquimod for Preventing Keloid Recurrence Not yet recruiting NCT03760250 Phase 2 Imiquimod 5% cream
38 Light Emitting Diode-Red Light (LED-RL) Phototherapy for Skin Scarring Prevention Not yet recruiting NCT03795116 Phase 2
39 Therapeutic Study of Bevacizumab Injection Directly Inside the Keloid Tissue Terminated NCT01408953 Phase 2
40 Sorafenib for Patients With Extensive Keloids Terminated NCT01425216 Phase 2 Sorafenib
41 Efficacy 2 Part Study of Identification of Keloid Biomarkers and Effect of QAX576 on Keloid Recurrence Terminated NCT00987545 Phase 2 QAX576;QAX576 placebo
42 Comparison of Dual-mode ER:YAG Laser in Patients With Long Keloid/Hypertrophic Scars Withdrawn NCT02546076 Phase 2
43 Calcium Electroporation for the Treatment of Keloids Unknown status NCT01941914 Phase 1 Calcium chloride
44 Fractional Photothermolysis for the Treatment of Burn Scars Unknown status NCT01005992 Phase 1
45 FS2 Safety and Tolerability Study in Healthy Volunteers Completed NCT02340325 Phase 1 Acute Application of kynurenic acid cream;Chronic application of kynurenic acid cream
46 High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin Completed NCT02630303 Phase 1
47 A Pilot Study of Intralesional Injection of Triamcinolone Acetonide for Desmoid Tumors Recruiting NCT03627741 Phase 1 Triamcinolone Acetonide
48 Phase 1 Study of HF-LED-RL in Fitzpatrick Skin Types I to III Recruiting NCT03433222 Phase 1
49 Study to Evaluate Fractional Collagen Synthesis Within Keloid Scars and Identify Biomarkers of Keloid Scars Terminated NCT01978301 Phase 1 Triamcinolone acetonide;Placebo
50 Prevention of Hypertrophic Scars or Keloids Unknown status NCT00849004 Not Applicable

Search NIH Clinical Center for Keloids

Genetic Tests for Keloids

Anatomical Context for Keloids

MalaCards organs/tissues related to Keloids:

41
Skin, Liver, Endothelial, Kidney, T Cells, Heart, Breast

Publications for Keloids

Articles related to Keloids:

(show top 50) (show all 942)
# Title Authors Year
1
Radiation Therapy, Keloids ( 29763148 )
2018
2
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ? ( 29240586 )
2018
3
Facial Plastic Surgery Controversies: Keloids. ( 29636144 )
2018
4
Evaluating the Therapeutic Success of Keloids Treated With Cryotherapy and Intralesional Corticosteroids Using Noninvasive Objective Measures. ( 29701618 )
2018
5
Centella asiatica (CentellicumAr) facilitates the regular healing of surgical scars in subjects at high risk of keloids. ( 29623705 )
2018
6
Genomic risk variants at 3q22.3 are associated with keloids in a Chinese Han population. ( 29511450 )
2018
7
The Effects of Postoperative Intralesional Corticosteroids in the Prevention of Recurrent Earlobe Keloids: A Multispecialty Retrospective Review. ( 29381548 )
2018
8
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ? ( 29240593 )
2018
9
Treatment of auricular keloids by triple combination therapy: Surgical excision, platelet-rich plasma, and cryosurgery. ( 29663626 )
2018
10
Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids. ( 29498630 )
2018
11
Comparison of intralesional verapamil versus intralesional corticosteroids in treatment of keloids and hypertrophic scars: A randomized controlled trial. ( 29886113 )
2018
12
The efficacy of excision followed by intralesional 5-fluorouracil and triamcinolone acetonide versus excision followed by radiotherapy in the treatment of ear keloids: A randomized control trial. ( 29534885 )
2018
13
The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review. ( 29401161 )
2018
14
Optimizing Radiotherapy for Keloids: A Meta-Analysis Systematic Review Comparing Recurrence Rates Between Different Radiation Modalities. ( 29239971 )
2018
15
Combination therapy for bulky auricular keloids: a clinical experience. ( 29757045 )
2018
16
Efficacy and the toxicity of the interstitial high-dose-rate brachytherapy in the management of recurrent keloids: 5-year outcomes. ( 29305151 )
2018
17
Coexistence of keloids and pilomatricoma in a patient with Rubinstein-Taybi syndrome. ( 29469775 )
2018
18
Dose Effect in Adjuvant Radiation Therapy for the Treatment of Resected Keloids. ( 29970316 )
2018
19
Further evidence for T-cell involvement in the pathogenesis of keloids. ( 29668095 )
2018
20
Methylation of secreted frizzled-related protein 1 (SFRP1) promoter downregulates Wnt/I^-catenin activity in keloids. ( 29455276 )
2018
21
Erosive Arthritis, Fibromatosis, and Keloids: A Rare Dermatoarthropathy. ( 29850357 )
2018
22
Complete excision of proliferating core in auricular keloids significantly reduces local recurrence: A prospective study. ( 29083048 )
2018
23
Optimizing Radiotherapy for Keloids. ( 29319568 )
2018
24
A retrospective analysis of surgical resection of large ear keloids. ( 29962005 )
2018
25
Abnormal Presentation of Aggressive Fibromatosis After Radiotherapy for Keloids: Case Report and Brief Literature Review. ( 30557185 )
2018
26
Commentary on The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review. ( 29309344 )
2018
27
Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial. ( 30340861 )
2018
28
Two Cases of Granular Cell Tumors that Clinically Mimicked Hypertrophic Scars and Keloids. ( 30464145 )
2018
29
Botulinum toxin type A for the treatment and prevention of hypertrophic scars and keloids: Updated review. ( 30548742 )
2018
30
Downregulation of miR‑637 promotes proliferation and metastasis by targeting Smad3 in keloids. ( 29845237 )
2018
31
A comparative study of various modalities in the treatment of keloids. ( 29993130 )
2018
32
Plasma Angiotensin-converting Enzyme Levels in Patients With Keloids and/or Hypertension. ( 30059342 )
2018
33
Comparison of Intralesional Triamcinolone Acetonide, 5-Fluorouracil, and Their Combination in Treatment of Keloids. ( 30083505 )
2018
34
Drug-free microneedles in the treatment of keloids: a single-blinded intraindividual controlled clinical trial. ( 30101410 )
2018
35
Spontaneous Keloids: A Literature Review. ( 30114700 )
2018
36
Aesthetic reconstruction of extensive pubic keloids using bilateral modified keystone flaps. ( 30126023 )
2018
37
Gallic acid inhibits fibroblast growth and migration in keloids through the AKT/ERK signaling pathway. ( 30265275 )
2018
38
Gene Expression of Neurotrophins and Their Receptors in Keloids. ( 30325834 )
2018
39
Patient-reported outcomes for keloids: a systematic review. ( 30375208 )
2018
40
Two Cases of Sclerotic Fibroma of the Skin that Mimicked Keloids Clinically. ( 30464146 )
2018
41
Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids. ( 29069016 )
2017
42
Reconstitution of Human Keloids in Mouse Skin. ( 28507865 )
2017
43
Pediatric dermatology procedures and pearls: Multimodal revision of earlobe keloids. ( 29266377 )
2017
44
Intralesional cryotherapy for hypertrophic scars and keloids: a review. ( 29799581 )
2017
45
Treatment of Keloids With Excision and Adjuvant Radiation: A Single Center Experience and Review of the Literature. ( 27775986 )
2017
46
Measurement of Pressure in Compressive Magnet Therapy for Auricular Keloids. ( 28607859 )
2017
47
Morphological and morphometric analysis of the effects of intralesional tamoxifen on keloids. ( 28440733 )
2017
48
Techniques for Optimizing Surgical Scars, Part 2: Hypertrophic Scars and Keloids. ( 29282183 )
2017
49
Identification of skin-related lncRNAs as potential biomarkers that involved in Wnt pathways in keloids. ( 28404955 )
2017
50
miR-141-3p inhibits fibroblast proliferation and migration by targeting GAB1 in keloids. ( 28619509 )
2017

Variations for Keloids

Expression for Keloids

Search GEO for disease gene expression data for Keloids.

Pathways for Keloids

Pathways related to Keloids according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CD36 MMP1 TGFB1 TGFB3 TNC
2
Show member pathways
12.92 FAS SMAD2 SMAD3 TGFB1 TGFB3
3
Show member pathways
12.75 SMAD2 SMAD3 TGFB1 TGFB3
4
Show member pathways
12.72 SMAD2 SMAD3 SMAD7 TGFB1
5 12.71 FAS MMP1 SMAD2 SMAD3 TGFB1 TGFB3
6
Show member pathways
12.66 SMAD2 SMAD3 TGFB1 TGFB3
7
Show member pathways
12.65 MMP1 TGFB1 TGFB3 TNC
8
Show member pathways
12.52 SMAD2 SMAD3 TGFB1 TGFB3
9
Show member pathways
12.46 SMAD2 SMAD3 TGFB1 TGFB3
10
Show member pathways
12.4 SMAD2 SMAD3 TGFB1 TGFB3
11 12.35 SMAD2 SMAD3 TGFB1 TGFB3
12 12.3 SMAD2 SMAD3 TGFB1 TGFB3
13
Show member pathways
12.24 SMAD2 SMAD3 SMAD7
14
Show member pathways
12.23 SMAD2 SMAD3 SMAD7 TGFB1
15 12.19 FAS SMAD2 TGFB1
16 12.17 SMAD2 SMAD3 TGFB1 TGFB3
17
Show member pathways
12.13 SMAD2 SMAD3 TGFB1
18 12.1 SMAD2 SMAD3 TGFB1 TGFB3
19 12.06 MMP1 SMAD2 SMAD7
20 12.05 MMP1 SMAD2 SMAD3 TGFB1 TGFB3
21
Show member pathways
12.02 SMAD2 SMAD3 TGFB1 TGFB3
22 11.99 SMAD2 SMAD3 TGFB1 TGFB3
23
Show member pathways
11.99 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
24 11.99 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
25 11.98 FAS SMAD3 TGFB1
26
Show member pathways
11.97 SMAD2 SMAD3 TGFB1 TGFB3
27 11.92 CD36 MMP1 TGFB1
28
Show member pathways
11.82 SMAD2 SMAD3 TGFB1
29 11.82 SMAD2 SMAD3 TGFB1 TGFB3
30 11.8 MMP1 TGFB1 TGFB3
31 11.79 TGFB1 TGFB3 TNC
32
Show member pathways
11.72 SMAD2 SMAD3 TGFB1
33 11.72 SMAD2 SMAD3 SMAD7
34 11.7 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
35 11.68 CD36 TGFB1 TGFB3
36 11.65 SMAD2 SMAD3 SMAD7 TGFB1
37 11.63 SMAD2 SMAD3 TGFB1 TGFB3
38
Show member pathways
11.62 SMAD2 SMAD3 SMAD7 TGFB1
39 11.58 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
40 11.57 TGFB1 TGFB3 TNC
41
Show member pathways
11.53 SMAD2 SMAD3 TGFB1 TGFB3
42 11.52 MMP1 SMAD3 TGFB1
43 11.52 SMAD2 SMAD3 SMAD7 TGFB1
44 11.49 CD36 TGFB1 TGFB3
45 11.46 MMP1 SMAD2 SMAD3
46 11.31 MMP1 TNC
47 11.22 MMP1 SMAD2 SMAD3 SMAD7 TGFB1 TNC
48 11.21 SMAD2 SMAD3
49
Show member pathways
11.17 SMAD7 TGFB1 TGFB3
50 11.15 SMAD2 SMAD3 TGFB1 TGFB3

GO Terms for Keloids

Cellular components related to Keloids according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.46 CD36 FAS TGFB1 TGFB3
2 transcription factor complex GO:0005667 9.43 SMAD2 SMAD3 SMAD7
3 SMAD protein complex GO:0071141 8.96 SMAD2 SMAD3
4 heteromeric SMAD protein complex GO:0071144 8.62 SMAD2 SMAD3

Biological processes related to Keloids according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.98 SMAD2 SMAD3 TGFB1 TGFB3
2 positive regulation of gene expression GO:0010628 9.97 CD36 SMAD2 SMAD3 TGFB1 TNC
3 protein deubiquitination GO:0016579 9.91 SMAD2 SMAD3 SMAD7
4 negative regulation of gene expression GO:0010629 9.91 CD36 SMAD2 TGFB1
5 in utero embryonic development GO:0001701 9.88 SMAD2 SMAD3 TGFB3
6 regulation of cell proliferation GO:0042127 9.87 TGFB1 TGFB3 TNC
7 response to hypoxia GO:0001666 9.87 SMAD3 TGFB1 TGFB3
8 platelet degranulation GO:0002576 9.85 CD36 TGFB1 TGFB3
9 cellular response to transforming growth factor beta stimulus GO:0071560 9.78 SMAD3 SMAD7 TGFB1
10 SMAD protein signal transduction GO:0060395 9.78 SMAD2 SMAD3 TGFB1 TGFB3
11 extrinsic apoptotic signaling pathway GO:0097191 9.75 FAS SMAD3 TGFB1
12 positive regulation of protein secretion GO:0050714 9.73 TGFB1 TGFB3
13 embryonic cranial skeleton morphogenesis GO:0048701 9.73 SMAD2 SMAD3
14 gastrulation GO:0007369 9.73 SMAD2 SMAD3
15 positive regulation of bone mineralization GO:0030501 9.73 SMAD3 TGFB1 TGFB3
16 mammary gland development GO:0030879 9.72 TGFB1 TGFB3
17 negative regulation of mitotic cell cycle GO:0045930 9.72 SMAD3 TGFB1
18 response to progesterone GO:0032570 9.72 TGFB1 TGFB3
19 digestive tract development GO:0048565 9.72 TGFB1 TGFB3
20 mesoderm formation GO:0001707 9.72 SMAD2 SMAD3
21 positive regulation of protein import into nucleus GO:0042307 9.71 SMAD3 TGFB1
22 face morphogenesis GO:0060325 9.71 TGFB1 TGFB3
23 developmental growth GO:0048589 9.71 SMAD2 SMAD3
24 positive regulation of epithelial to mesenchymal transition GO:0010718 9.71 SMAD2 SMAD3 TGFB1 TGFB3
25 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.7 SMAD3 TGFB1
26 positive regulation of collagen biosynthetic process GO:0032967 9.7 TGFB1 TGFB3
27 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.7 SMAD7 TGFB1
28 adrenal gland development GO:0030325 9.69 SMAD2 SMAD3
29 endoderm development GO:0007492 9.69 SMAD2 SMAD3 TGFB1
30 embryonic pattern specification GO:0009880 9.68 SMAD2 SMAD3
31 signal transduction involved in regulation of gene expression GO:0023019 9.68 SMAD2 SMAD3
32 activin receptor signaling pathway GO:0032924 9.68 SMAD2 SMAD3
33 secondary palate development GO:0062009 9.67 SMAD2 TGFB3
34 lens fiber cell differentiation GO:0070306 9.67 SMAD3 TGFB1
35 cell-cell junction organization GO:0045216 9.67 SMAD3 TGFB1 TGFB3
36 ureteric bud development GO:0001657 9.67 SMAD2 SMAD3 SMAD7 TGFB1
37 pathway-restricted SMAD protein phosphorylation GO:0060389 9.66 SMAD7 TGFB1
38 positive regulation of SMAD protein signal transduction GO:0060391 9.66 TGFB1 TGFB3
39 nodal signaling pathway GO:0038092 9.65 SMAD2 SMAD3
40 primary miRNA processing GO:0031053 9.65 SMAD2 SMAD3
41 response to cholesterol GO:0070723 9.65 SMAD2 TGFB1
42 transforming growth factor beta receptor signaling pathway GO:0007179 9.65 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
43 salivary gland morphogenesis GO:0007435 9.64 TGFB1 TGFB3
44 embryonic foregut morphogenesis GO:0048617 9.63 SMAD2 SMAD3
45 pericardium development GO:0060039 9.63 SMAD2 SMAD3
46 response to laminar fluid shear stress GO:0034616 9.63 SMAD7 TGFB1 TGFB3
47 common-partner SMAD protein phosphorylation GO:0007182 9.62 SMAD2 TGFB1
48 negative regulation of macrophage cytokine production GO:0010936 9.62 TGFB1 TGFB3
49 positive regulation of extracellular matrix assembly GO:1901203 9.61 SMAD3 TGFB1
50 SMAD protein complex assembly GO:0007183 9.61 SMAD2 SMAD3 TGFB1

Molecular functions related to Keloids according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.8 SMAD2 SMAD3 TGFB1 TGFB3
2 R-SMAD binding GO:0070412 9.51 SMAD2 SMAD3
3 transforming growth factor beta binding GO:0050431 9.48 CD36 TGFB3
4 enhancer binding GO:0035326 9.46 SMAD2 SMAD3
5 co-SMAD binding GO:0070410 9.43 SMAD2 SMAD3
6 I-SMAD binding GO:0070411 9.4 SMAD2 SMAD7
7 primary miRNA binding GO:0070878 9.37 SMAD2 SMAD3
8 type II transforming growth factor beta receptor binding GO:0005114 9.32 TGFB1 TGFB3
9 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.26 SMAD2 SMAD3
10 transforming growth factor beta receptor binding GO:0005160 9.26 SMAD2 SMAD3 TGFB1 TGFB3
11 type III transforming growth factor beta receptor binding GO:0034714 9.16 TGFB1 TGFB3
12 type I transforming growth factor beta receptor binding GO:0034713 8.92 SMAD2 SMAD7 TGFB1 TGFB3

Sources for Keloids

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