Aliases & Classifications for Keloids

MalaCards integrated aliases for Keloids:

Name: Keloids 38 76
Keloid Disorder 76
Keloid 55

Summaries for Keloids

MalaCards based summary : Keloids, also known as keloid disorder, is related to hypertrophic scars and localized scleroderma. An important gene associated with Keloids is H19 (H19, Imprinted Maternally Expressed Transcript
The results confirmed that knockdown of H19 inhibited mTOR and VEGF expression.
Dysfunction Pattern: Expression [low expression]), and among its related pathways/superpathways are Integrin Pathway and Toll-like Receptor Signaling Pathway. The drugs Fluorouracil and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and bone, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 76 Keloid, also known as keloid disorder and keloidal scar, is the formation of a type of scar which,... more...

Related Diseases for Keloids

Diseases related to Keloids via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 hypertrophic scars 30.9 CD36 SMAD2 SMAD3 TGFB1 TGFB3
2 localized scleroderma 29.9 MMP1 SMAD3 TGFB1
3 gingival overgrowth 29.5 CD36 MMP1 TGFB1
4 nephrogenic systemic fibrosis 29.0 SMAD2 SMAD3 SMAD7 TGFB1
5 keloid formation 12.4
6 torticollis, keloids, cryptorchidism, and renal dysplasia 12.1
7 x-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome 11.9
8 premature aging syndrome, penttinen type 11.2
9 lobomycosis 11.2
10 frontometaphyseal dysplasia 2 10.9
11 desmoid tumor 10.9
12 trueb burg bottani syndrome 10.9
13 osteochondrosis 10.4 CD36 TGFB1
14 burn scar 10.4 FAS TGFB1
15 epithelial basement membrane dystrophy 10.3 FAS TGFB1
16 recessive dystrophic epidermolysis bullosa 10.3 MMP1 TGFB1
17 odontogenic myxoma 10.3 CD36 MMP1
18 spastic paraplegia 3, autosomal dominant 10.3 SMAD2 TGFB1
19 pustulosis palmaris et plantaris 10.3 SMAD7 TGFB1
20 lattice corneal dystrophy 10.2 FAS TGFB1
21 penile disease 10.2 SMAD2 SMAD3 TGFB1
22 gingival disease 10.2 MMP1 TGFB1
23 urinary tract obstruction 10.2 SMAD2 SMAD3 TGFB1
24 tuberculoid leprosy 10.2 TGFB1 TGFB3
25 type i 10.2
26 osteofibrous dysplasia 10.1 CD36 TGFB1
27 endotheliitis 10.1
28 fibromatosis, gingival, 1 10.1 CD36 MMP1 TGFB1
29 chromosome 16p13.3 deletion syndrome, proximal 10.1
30 gingival fibromatosis 10.1 CD36 MMP1 TGFB1
31 pulmonary fibrosis 10.0 SMAD3 SMAD7 TGFB1
32 ocular cicatricial pemphigoid 10.0 CD36 TGFB1
33 interstitial keratitis 9.9 CD36 TNC
34 burns 9.9
35 blastomycosis 9.9
36 osteoarthritis 9.8 H19 MMP1 TGFB1
37 bethlem myopathy 1 9.8
38 insulin-like growth factor i 9.8
39 scar contracture 9.8
40 leiomyoma 9.8
41 dermatitis 9.8
42 myopathy 9.8
43 herpes zoster 9.8
44 psoriasis 9.8
45 light chain deposition disease 9.8 MMP1 TNC
46 pneumoconiosis 9.8 FAS H19 TGFB1
47 anterior segment dysgenesis 1 9.7
48 pemphigus vulgaris, familial 9.7
49 torticollis 9.7
50 axenfeld-rieger syndrome, type 3 9.7

Graphical network of the top 20 diseases related to Keloids:



Diseases related to Keloids

Symptoms & Phenotypes for Keloids

MGI Mouse Phenotypes related to Keloids:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.14 SMAD7 TGFB1 TGFB3 TNC CD36 FAS
2 cardiovascular system MP:0005385 10.07 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
3 homeostasis/metabolism MP:0005376 10.06 CD36 FAS MMP1 SMAD2 SMAD3 SMAD7
4 cellular MP:0005384 10.05 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
5 digestive/alimentary MP:0005381 10.02 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
6 hematopoietic system MP:0005397 9.98 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
7 craniofacial MP:0005382 9.97 FAS SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
8 immune system MP:0005387 9.97 CD36 FAS MMP1 SMAD2 SMAD3 SMAD7
9 endocrine/exocrine gland MP:0005379 9.93 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
10 liver/biliary system MP:0005370 9.72 CD36 FAS SMAD2 SMAD3 TGFB1
11 nervous system MP:0003631 9.7 SMAD2 SMAD3 TGFB1 TGFB3 TNC CD36
12 neoplasm MP:0002006 9.65 SMAD3 TGFB1 FAS MMP1 SMAD2
13 skeleton MP:0005390 9.43 CD36 FAS SMAD2 SMAD3 TGFB1 TGFB3
14 vision/eye MP:0005391 9.1 CD36 FAS SMAD2 SMAD3 TGFB1 TGFB3

Drugs & Therapeutics for Keloids

Drugs for Keloids (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 110)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 4,Phase 2 51-21-8 3385
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 124-94-7 31307
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Povidone-iodine Approved Phase 4 25655-41-8
5
Ethanol Approved Phase 4 64-17-5 702
6
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
7
Petrolatum Approved, Investigational Phase 4 8009-03-8
8
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
9
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
10
Prilocaine Approved Phase 4 721-50-6 4906
11
Tetracaine Approved, Vet_approved Phase 4,Not Applicable 94-24-6 5411
12
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
13
Morphine Approved, Investigational Phase 4 57-27-2 5288826
14
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
15
Verapamil Approved Phase 4 52-53-9 2520
16
Tocopherol Approved, Investigational, Nutraceutical Phase 4 1406-66-2 14986
17
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
18
Butyric Acid Experimental, Investigational Phase 4 107-92-6 264
19 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1,Not Applicable
20 Antimetabolites Phase 4,Phase 2
21 Antimetabolites, Antineoplastic Phase 4,Phase 2
22 glucocorticoids Phase 4,Phase 3,Phase 1,Not Applicable
23 Hormone Antagonists Phase 4,Phase 3,Phase 1,Not Applicable
24 Hormones Phase 4,Phase 3,Phase 1,Not Applicable
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Not Applicable
26 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 triamcinolone acetonide Phase 4,Phase 3,Phase 1,Not Applicable
28 Triamcinolone diacetate Phase 4,Phase 3,Phase 1,Not Applicable
29 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 1,Not Applicable
30 Anesthetics Phase 4,Not Applicable
31 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
32 Emollients Phase 4,Phase 3
33 Calcium, Dietary Phase 4,Phase 1
34 Antiemetics Phase 4
35 Antineoplastic Agents, Hormonal Phase 4
36 Autonomic Agents Phase 4
37 BB 1101 Phase 4
38 Dexamethasone acetate Phase 4 1177-87-3
39 Gastrointestinal Agents Phase 4,Not Applicable
40 HIV Protease Inhibitors Phase 4
41 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
42
protease inhibitors Phase 4
43 Anti-Infective Agents, Local Phase 4
44 Antioxidants Phase 4
45 Central Nervous System Depressants Phase 4,Not Applicable
46 Cortisol succinate Phase 4
47 Hydrocortisone 17-butyrate 21-propionate Phase 4
48 Hydrocortisone acetate Phase 4
49 Hydrocortisone-17-butyrate Phase 4
50 Micronutrients Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 86)
# Name Status NCT ID Phase Drugs
1 Pilot Study to Evaluate Clinical Outcomes With the Use of Biovance Following Keloid Scar Revision Surgery Unknown status NCT02521402 Phase 4
2 Keloid Scarring: Treatment and Pathophysiology Unknown status NCT01295099 Phase 4 5- fluorouracil;Triamcinolone
3 A Randomized Clinical Study Comparing Two Closure Techniques of Excised Keloids Unknown status NCT00519493 Phase 4
4 Surgical Excision and Intralesional Steroid Injection for Prevention of Post Caesarean Keloid Recurrence Completed NCT03239964 Phase 4 Dexamethasone
5 A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars Completed NCT00754247 Phase 4 0.5% hydrocortisone, silicone, vitamin E lotion;Onion extract gel;Cetearyl alcohol lotion
6 Effect of Transparent, Self-drying Silicone Gel on the Treatment of Hypertrophic Abdominal Scars Completed NCT01078428 Phase 4
7 Radiesse® Injectable Dermal Filler for the Treatment of Nasolabial Folds in Persons of Color Completed NCT01012388 Phase 4
8 Treatment of Keloidscars With Intralesional Triamcinolone and 5-fluorouracil Injections-prospective, Randomized, Controlled Trial - Pilot Study Completed NCT02155439 Phase 4 5-fluorouracil;Triamcinolone
9 A Post-Market Study to Evaluate Adverse Event Incidence Rates in Patients With Skin of Color Undergoing Correction of Nasolabial Folds With Hylaform, Hylaform Plus and Captique. Completed NCT00293163 Phase 4
10 Pilot Study of a Novel 532nm KTP Laser for the Treatment of Fresh Surgical Scars Completed NCT01789346 Phase 4
11 Post Market Safety Study and Effectiveness With Evolence in Subjects With Skin Color Types IV-VI Completed NCT00891774 Phase 4
12 7% Lidocaine/7% Tetracaine Cream Versus 2,5% Lidocaine / 2,5% Prilocaine Cream Completed NCT02372786 Phase 4 2,5% lidocaine / 2,5% prilocaine cream;7% lidocaine / 7% tetracaine cream
13 The Efficacy of Laser Assisted Hair Removal in the Treatment of Acne Keloidalis Nuchae; a Pilot Study Completed NCT01548898 Phase 4
14 Facial Lipoatrophy Correction Experience With SCULPTRA ("FACES" Study) Completed NCT00360932 Phase 4
15 Use of On-Q Pump for Pain Post C-Section Enrolling by invitation NCT02579629 Phase 4 Ropivacaine 0.1%;Ropivacaine 0.2%;Normal saline
16 Verapamil vs Steroid to Prevent Keloid Recurrence Terminated NCT01720056 Phase 4 Verapamil;Kenalog 10
17 Safety and Efficacy of Infrared Diode Laser on Improvement of Scar and Prevention of Recurrence of Excised Keloid Unknown status NCT01158196 Phase 3
18 Scars After Central Venous Catheters Unknown status NCT01113125 Phase 3 Betamethason-17-valerate and fusidic acid;Fusidic Acid
19 Silicone Gel Versus Onion Extract Gel as Prevention for Postsurgical Scars Unknown status NCT01861119 Phase 3 Silicone gel Kelo-cort™;;Onion extract gel Contractubex™
20 CICATRIX in the Treatment of Hypertrophic Scars and Keloids Scars Completed NCT00993005 Phase 3
21 Efficacy of Intralesional Triamcinolone and 8% Topical Pirfenidone for Treatment of Keloid Scars Recruiting NCT02823236 Phase 3 Topical Pirfenidone;Triamcinolone + Pirfenidone;Intralesional Triamcinolone
22 A Study to Evaluate the Effectiveness and Safety of RXI-109 on the Outcome of Keloid Excision Surgery in Healthy Adults Completed NCT02079168 Phase 2 RXI-109;Placebo
23 Exploratory Study of the Efficacy and Safety of Juvista 250ng When Administered Following Excision of Ear Lobe Keloids Completed NCT00836147 Phase 1, Phase 2 Avotermin (Juvista);Placebo
24 A Pilot Study of Apligraf for the Treatment and Prevention of Recurrence of Excised Keloids Completed NCT00587587 Phase 1, Phase 2
25 Evaluation of the Initial Safety and Efficacy of Keloid Lesions Treated With MF-4181 Completed NCT01446770 Phase 2
26 Trial of Juvista (Avotermin) Following Removal of Ear Lobe Keloid Scars Completed NCT00469235 Phase 1, Phase 2 Avotermin
27 Safety of Juvista When Administered Following Excision of Ear Lobe Keloids Completed NCT00710333 Phase 1, Phase 2 Avotermin;placebo
28 A Study to Evaluate the Safety and Efficacy of AZX100 Drug Product Following Excision of Keloid Scars Completed NCT00825916 Phase 2 AZX100 Drug Product;AZX100 Drug Product;Placebo
29 A Study to Evaluate the Safety and Efficacy of Additional Doses of AZX100 Drug Product Following Excision of Keloid Scars Completed NCT00892723 Phase 2 AZX100 Drug Product;Placebo;AZX100 Drug Product
30 Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix Completed NCT00129428 Phase 1, Phase 2
31 Study of GBT009 for Treatment of Incisional Wounds Following Breast Reconstruction Surgery Completed NCT01053897 Phase 2
32 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts Recruiting NCT02705352 Phase 2 5-Fluorouracil
33 Therapeutic Study of Bevacizumab Injection Directly Inside the Keloid Tissue Terminated NCT01408953 Phase 2
34 Sorafenib for Patients With Extensive Keloids Terminated NCT01425216 Phase 2 Sorafenib
35 Efficacy 2 Part Study of Identification of Keloid Biomarkers and Effect of QAX576 on Keloid Recurrence Terminated NCT00987545 Phase 2 QAX576;QAX576 placebo
36 Comparison of Dual-mode ER:YAG Laser in Patients With Long Keloid/Hypertrophic Scars Withdrawn NCT02546076 Phase 2
37 Calcium Electroporation for the Treatment of Keloids Unknown status NCT01941914 Phase 1 Calcium chloride
38 Fractional Photothermolysis for the Treatment of Burn Scars Unknown status NCT01005992 Phase 1
39 FS2 Safety and Tolerability Study in Healthy Volunteers Completed NCT02340325 Phase 1 Acute Application of kynurenic acid cream;Chronic application of kynurenic acid cream
40 High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin Completed NCT02630303 Phase 1
41 Phase 1 Study of HF-LED-RL in Fitzpatrick Skin Types I to III Recruiting NCT03433222 Phase 1
42 Study to Evaluate Fractional Collagen Synthesis Within Keloid Scars and Identify Biomarkers of Keloid Scars Terminated NCT01978301 Phase 1 Triamcinolone acetonide;Placebo
43 Prevention of Hypertrophic Scars or Keloids Unknown status NCT00849004 Not Applicable
44 A Substantial Equivalence Study of RD04723 and Predicate Device Unknown status NCT01736969 Not Applicable
45 Influence of a Silicone Gel (Dermatix®) on Thoracic Scar Formation After Harvesting of Autologous Rib Cartilage Unknown status NCT00565552 Not Applicable Silicone gel (Dermatix®)
46 A Prospective Comparison of Robotic and Endoscopic SMG Resection Via Retroauricular Approach Unknown status NCT01726907 Not Applicable
47 NdYag Laser for Acne Keloidalis Nuchae Unknown status NCT00757315 Not Applicable Topical corticosteroid alone
48 Intralesional Cryosurgery for Basal Cell Carcinoma - a Feasibility Study Unknown status NCT01633515 Not Applicable
49 Treatment of Keloid Scar by Autologous Platelet Rich Plasma Obtained With RgenKit-BCT Completed NCT02922972 Not Applicable
50 Assessing and Improving Patient Knowledge About Keloid Scars (Keloids) Completed NCT01176877 Not Applicable

Search NIH Clinical Center for Keloids

Genetic Tests for Keloids

Anatomical Context for Keloids

MalaCards organs/tissues related to Keloids:

41
Skin, Endothelial, Bone, Liver, T Cells, Breast, Kidney

Publications for Keloids

Articles related to Keloids:

(show top 50) (show all 1033)
# Title Authors Year
1
Radiation Therapy, Keloids ( 29763148 )
2018
2
Angiomatoid and desmoplastic Spitz nevus presenting as a keloidal nodule. ( 29582459 )
2018
3
A Rare Case of Misdiagnosis: Recurrence of Dermatofibrosarcoma Protuberans That Was Treated Surgicallyas a Keloid. ( 29416224 )
2018
4
Delayed diagnosis of dermal leiomyosarcoma mimicking keloid scar. ( 29374640 )
2018
5
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ? ( 29240586 )
2018
6
Facial Plastic Surgery Controversies: Keloids. ( 29636144 )
2018
7
Three-dimensional poly lactic-co-glycolic acid scaffold containing autologous platelet-rich plasma supports keloid fibroblast growth and contributes to keloid formation in a nude mouse model. ( 29122407 )
2018
8
Evaluating the Therapeutic Success of Keloids Treated With Cryotherapy and Intralesional Corticosteroids Using Noninvasive Objective Measures. ( 29701618 )
2018
9
Centella asiatica (CentellicumAr) facilitates the regular healing of surgical scars in subjects at high risk of keloids. ( 29623705 )
2018
10
Genomic risk variants at 3q22.3 are associated with keloids in a Chinese Han population. ( 29511450 )
2018
11
The Effects of Postoperative Intralesional Corticosteroids in the Prevention of Recurrent Earlobe Keloids: A Multispecialty Retrospective Review. ( 29381548 )
2018
12
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ? ( 29240593 )
2018
13
Keloid formation after syndactyly release in a patient with macrodactyly - methotrexate treatment. ( 29973103 )
2018
14
Treatment of auricular keloids by triple combination therapy: Surgical excision, platelet-rich plasma, and cryosurgery. ( 29663626 )
2018
15
Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids. ( 29498630 )
2018
16
Comparison of intralesional verapamil versus intralesional corticosteroids in treatment of keloids and hypertrophic scars: A randomized controlled trial. ( 29886113 )
2018
17
The efficacy of excision followed by intralesional 5-fluorouracil and triamcinolone acetonide versus excision followed by radiotherapy in the treatment of ear keloids: A randomized control trial. ( 29534885 )
2018
18
The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review. ( 29401161 )
2018
19
Tumor suppressive role of miR-1224-5p in keloid proliferation, apoptosis and invasion via the TGF-I^1/Smad3 signaling pathway. ( 29050938 )
2018
20
Optimizing Radiotherapy for Keloids: A Meta-Analysis Systematic Review Comparing Recurrence Rates Between Different Radiation Modalities. ( 29239971 )
2018
21
Combination therapy for bulky auricular keloids: a clinical experience. ( 29757045 )
2018
22
Efficacy and the toxicity of the interstitial high-dose-rate brachytherapy in the management of recurrent keloids: 5-year outcomes. ( 29305151 )
2018
23
Coexistence of keloids and pilomatricoma in a patient with Rubinstein-Taybi syndrome. ( 29469775 )
2018
24
Gene-based evaluation of low-frequency variation and genetically-predicted gene expression impacting risk of keloid formation. ( 29484647 )
2018
25
Dose Effect in Adjuvant Radiation Therapy for the Treatment of Resected Keloids. ( 29970316 )
2018
26
Further evidence for T-cell involvement in the pathogenesis of keloids. ( 29668095 )
2018
27
Methylation of secreted frizzled-related protein 1 (SFRP1) promoter downregulates Wnt/I^-catenin activity in keloids. ( 29455276 )
2018
28
Erosive Arthritis, Fibromatosis, and Keloids: A Rare Dermatoarthropathy. ( 29850357 )
2018
29
Complete excision of proliferating core in auricular keloids significantly reduces local recurrence: A prospective study. ( 29083048 )
2018
30
Optimizing Radiotherapy for Keloids. ( 29319568 )
2018
31
Keloid formation on neck after jugular central venous catheter placement: An unsightly unusual complication in a young female. ( 29416158 )
2018
32
A retrospective analysis of surgical resection of large ear keloids. ( 29962005 )
2018
33
Commentary on The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review. ( 29309344 )
2018
34
Downregulation of miRa89637 promotes proliferation and metastasis by targeting Smad3 in keloids. ( 29845237 )
2018
35
Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids. ( 29069016 )
2017
36
Reconstitution of Human Keloids in Mouse Skin. ( 28507865 )
2017
37
Pediatric dermatology procedures and pearls: Multimodal revision of earlobe keloids. ( 29266377 )
2017
38
Intralesional cryotherapy for hypertrophic scars and keloids: a review. ( 29799581 )
2017
39
Treatment of Keloids With Excision and Adjuvant Radiation: A Single Center Experience and Review of the Literature. ( 27775986 )
2017
40
Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis. ( 28287424 )
2017
41
Measurement of Pressure in Compressive Magnet Therapy for Auricular Keloids. ( 28607859 )
2017
42
Expansion of CD26 positive fibroblast population promotes keloid progression. ( 28454879 )
2017
43
Association of plasminogen activator inhibitor-1 and vitamin D receptor expression with the risk of keloid disease in a Chinese population. ( 28088270 )
2017
44
Morphological and morphometric analysis of the effects of intralesional tamoxifen on keloids. ( 28440733 )
2017
45
Techniques for Optimizing Surgical Scars, Part 2: Hypertrophic Scars and Keloids. ( 29282183 )
2017
46
Relationship between Keloid Formation and YAP/TAZ Signaling. ( 28740772 )
2017
47
Identification of skin-related lncRNAs as potential biomarkers that involved in Wnt pathways in keloids. ( 28404955 )
2017
48
miR-141-3p inhibits fibroblast proliferation and migration by targeting GAB1 in keloids. ( 28619509 )
2017
49
Histological analysis of hyalinised keloidal collagen formation in earlobe keloids over time: collagen hyalinisation starts in the perivascular area. ( 28467018 )
2017
50
Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population. ( 28437551 )
2017

Variations for Keloids

Expression for Keloids

Search GEO for disease gene expression data for Keloids.

Pathways for Keloids

Pathways related to Keloids according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CD36 MMP1 TGFB1 TGFB3 TNC
2
Show member pathways
12.91 FAS SMAD2 SMAD3 TGFB1 TGFB3
3
Show member pathways
12.75 SMAD2 SMAD3 TGFB1 TGFB3
4
Show member pathways
12.72 SMAD2 SMAD3 SMAD7 TGFB1
5 12.71 FAS MMP1 SMAD2 SMAD3 TGFB1 TGFB3
6
Show member pathways
12.66 SMAD2 SMAD3 TGFB1 TGFB3
7
Show member pathways
12.64 MMP1 TGFB1 TGFB3 TNC
8
Show member pathways
12.5 FAS SMAD3 TGFB1 TGFB3
9
Show member pathways
12.46 SMAD2 SMAD3 TGFB1 TGFB3
10
Show member pathways
12.4 SMAD2 SMAD3 TGFB1 TGFB3
11
Show member pathways
12.37 SMAD2 SMAD3 TGFB1 TGFB3
12 12.35 SMAD2 SMAD3 TGFB1 TGFB3
13 12.3 SMAD2 SMAD3 TGFB1 TGFB3
14
Show member pathways
12.24 SMAD2 SMAD3 SMAD7
15
Show member pathways
12.22 SMAD2 SMAD3 SMAD7 TGFB1
16 12.19 FAS SMAD2 TGFB1
17
Show member pathways
12.18 SMAD2 SMAD3 TGFB1 TGFB3
18 12.16 SMAD2 SMAD3 TGFB1 TGFB3
19
Show member pathways
12.12 SMAD2 SMAD3 TGFB1
20 12.09 SMAD2 SMAD3 TGFB1 TGFB3
21 12.06 MMP1 SMAD2 SMAD7
22 12.05 MMP1 SMAD2 SMAD3 TGFB1 TGFB3
23
Show member pathways
12.01 SMAD2 SMAD3 TGFB1 TGFB3
24
Show member pathways
11.99 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
25 11.99 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
26 11.98 FAS SMAD3 TGFB1
27 11.98 SMAD2 SMAD3 TGFB1 TGFB3
28 11.91 CD36 MMP1 TGFB1
29
Show member pathways
11.82 SMAD2 SMAD3 TGFB1
30 11.82 SMAD2 SMAD3 TGFB1 TGFB3
31 11.8 MMP1 TGFB1 TGFB3
32 11.79 TGFB1 TGFB3 TNC
33
Show member pathways
11.72 SMAD2 SMAD3 TGFB1
34 11.72 SMAD2 SMAD3 SMAD7
35 11.7 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
36 11.65 SMAD2 SMAD3 SMAD7 TGFB1
37
Show member pathways
11.62 SMAD2 SMAD3 SMAD7 TGFB1
38 11.58 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
39 11.56 TGFB1 TGFB3 TNC
40 11.52 SMAD2 SMAD3 SMAD7 TGFB1
41 11.51 MMP1 SMAD3 TGFB1
42 11.49 CD36 TGFB1 TGFB3
43 11.45 MMP1 SMAD2 SMAD3
44
Show member pathways
11.4 SMAD2 SMAD3 TGFB1
45 11.31 MMP1 TNC
46 11.22 MMP1 SMAD2 SMAD3 SMAD7 TGFB1 TNC
47 11.2 SMAD2 SMAD3
48
Show member pathways
11.17 SMAD7 TGFB1 TGFB3
49 11.15 SMAD2 SMAD3 TGFB1 TGFB3
50 11.14 SMAD2 TGFB1 TGFB3

GO Terms for Keloids

Cellular components related to Keloids according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.62 CD36 FAS TGFB1 TGFB3
2 transcription factor complex GO:0005667 9.43 SMAD2 SMAD3 SMAD7
3 extracellular matrix GO:0031012 9.26 MMP1 TGFB1 TGFB3 TNC
4 SMAD protein complex GO:0071141 9.16 SMAD2 SMAD3
5 heteromeric SMAD protein complex GO:0071144 8.62 SMAD2 SMAD3

Biological processes related to Keloids according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.99 SMAD2 SMAD3 TGFB1 TGFB3
2 regulation of cell proliferation GO:0042127 9.92 FAS TGFB1 TGFB3 TNC
3 positive regulation of gene expression GO:0010628 9.92 CD36 SMAD2 SMAD3 TGFB1 TNC
4 negative regulation of gene expression GO:0010629 9.9 CD36 SMAD2 TGFB1
5 in utero embryonic development GO:0001701 9.89 SMAD2 SMAD3 TGFB3
6 response to hypoxia GO:0001666 9.88 SMAD3 TGFB1 TGFB3
7 platelet degranulation GO:0002576 9.86 CD36 TGFB1 TGFB3
8 BMP signaling pathway GO:0030509 9.82 SMAD7 TGFB1 TGFB3
9 cellular response to transforming growth factor beta stimulus GO:0071560 9.78 SMAD3 SMAD7 TGFB1
10 SMAD protein signal transduction GO:0060395 9.78 SMAD2 SMAD3 TGFB1 TGFB3
11 extrinsic apoptotic signaling pathway GO:0097191 9.75 FAS SMAD3 TGFB1
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 CD36 SMAD3
13 positive regulation of bone mineralization GO:0030501 9.74 SMAD3 TGFB1 TGFB3
14 digestive tract development GO:0048565 9.73 TGFB1 TGFB3
15 positive regulation of protein secretion GO:0050714 9.73 TGFB1 TGFB3
16 gastrulation GO:0007369 9.73 SMAD2 SMAD3
17 mesoderm formation GO:0001707 9.73 SMAD2 SMAD3
18 negative regulation of mitotic cell cycle GO:0045930 9.73 SMAD3 TGFB1
19 mammary gland development GO:0030879 9.72 TGFB1 TGFB3
20 embryonic cranial skeleton morphogenesis GO:0048701 9.72 SMAD2 SMAD3
21 face morphogenesis GO:0060325 9.72 TGFB1 TGFB3
22 positive regulation of protein import into nucleus GO:0042307 9.72 SMAD3 TGFB1
23 developmental growth GO:0048589 9.71 SMAD2 SMAD3
24 embryonic pattern specification GO:0009880 9.71 SMAD2 SMAD3
25 positive regulation of collagen biosynthetic process GO:0032967 9.71 TGFB1 TGFB3
26 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.71 SMAD7 TGFB1
27 positive regulation of epithelial to mesenchymal transition GO:0010718 9.71 SMAD2 SMAD3 TGFB1 TGFB3
28 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.7 SMAD3 TGFB1
29 cell growth GO:0016049 9.7 TGFB1 TGFB3
30 signal transduction involved in regulation of gene expression GO:0023019 9.69 SMAD2 SMAD3
31 negative regulation of DNA replication GO:0008156 9.69 TGFB1 TGFB3
32 activin receptor signaling pathway GO:0032924 9.69 SMAD2 SMAD3
33 endoderm development GO:0007492 9.69 SMAD2 SMAD3 TGFB1
34 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.68 FAS SMAD3
35 pathway-restricted SMAD protein phosphorylation GO:0060389 9.68 SMAD7 TGFB1
36 secondary palate development GO:0062009 9.67 SMAD2 TGFB3
37 lens fiber cell differentiation GO:0070306 9.67 SMAD3 TGFB1
38 positive regulation of SMAD protein signal transduction GO:0060391 9.67 TGFB1 TGFB3
39 cell-cell junction organization GO:0045216 9.67 SMAD3 TGFB1 TGFB3
40 ureteric bud development GO:0001657 9.67 SMAD2 SMAD3 SMAD7 TGFB1
41 response to cholesterol GO:0070723 9.66 SMAD2 TGFB1
42 nodal signaling pathway GO:0038092 9.66 SMAD2 SMAD3
43 salivary gland morphogenesis GO:0007435 9.65 TGFB1 TGFB3
44 primary miRNA processing GO:0031053 9.65 SMAD2 SMAD3
45 transforming growth factor beta receptor signaling pathway GO:0007179 9.65 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
46 pericardium development GO:0060039 9.64 SMAD2 SMAD3
47 embryonic foregut morphogenesis GO:0048617 9.63 SMAD2 SMAD3
48 common-partner SMAD protein phosphorylation GO:0007182 9.63 SMAD2 TGFB1
49 SMAD protein complex assembly GO:0007183 9.63 SMAD2 SMAD3 TGFB1
50 regulation of striated muscle tissue development GO:0016202 9.62 SMAD3 TGFB1

Molecular functions related to Keloids according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.83 SMAD2 SMAD3 TGFB1 TGFB3
2 R-SMAD binding GO:0070412 9.51 SMAD2 SMAD3
3 transforming growth factor beta binding GO:0050431 9.49 CD36 TGFB3
4 enhancer binding GO:0035326 9.48 SMAD2 SMAD3
5 BMP receptor binding GO:0070700 9.46 TGFB1 TGFB3
6 co-SMAD binding GO:0070410 9.43 SMAD2 SMAD3
7 I-SMAD binding GO:0070411 9.4 SMAD2 SMAD7
8 primary miRNA binding GO:0070878 9.37 SMAD2 SMAD3
9 type II transforming growth factor beta receptor binding GO:0005114 9.32 TGFB1 TGFB3
10 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.26 SMAD2 SMAD3
11 transforming growth factor beta receptor binding GO:0005160 9.26 SMAD2 SMAD3 TGFB1 TGFB3
12 type III transforming growth factor beta receptor binding GO:0034714 9.16 TGFB1 TGFB3
13 type I transforming growth factor beta receptor binding GO:0034713 8.92 SMAD2 SMAD7 TGFB1 TGFB3

Sources for Keloids

3 CDC
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10 dbSNP
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17 ExPASy
19 FMA
28 GO
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