Aliases & Classifications for Keloids

MalaCards integrated aliases for Keloids:

Name: Keloids 39 77
Keloid 56 17
Keloid Disorder 77

External Ids:

Summaries for Keloids

MalaCards based summary : Keloids, also known as keloid, is related to hypertrophic scars and localized scleroderma. An important gene associated with Keloids is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Integrin Pathway and Toll-like Receptor Signaling Pathway. The drugs Fluorouracil and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and endothelial, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 77 Keloid, also known as keloid disorder and keloidal scar, is the formation of a type of scar which,... more...

Related Diseases for Keloids

Diseases related to Keloids via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 hypertrophic scars 31.9 CD36 SMAD2 SMAD3 TGFB1 TGFB3
2 localized scleroderma 30.3 MMP1 SMAD3 TGFB1
3 gingival overgrowth 29.7 CD36 MMP1 TGFB1
4 nephrogenic systemic fibrosis 29.4 SMAD2 SMAD3 SMAD7 TGFB1
5 keloid formation 12.6
6 torticollis, keloids, cryptorchidism, and renal dysplasia 12.5
7 x-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome 12.1
8 premature aging syndrome, penttinen type 11.4
9 lobomycosis 11.4
10 frontometaphyseal dysplasia 2 11.0
11 warburg-cinotti syndrome 11.0
12 desmoid tumor 11.0
13 trueb burg bottani syndrome 11.0
14 autosomal recessive cutis laxa type i 10.3 SMAD2 TGFB1
15 penile disease 10.2 SMAD2 TGFB1
16 chromosome 16p13.3 deletion syndrome, proximal 10.2
17 osteochondrosis 10.2 CD36 TGFB1
18 systemic scleroderma 10.2
19 spastic paraplegia 3, autosomal dominant 10.2 SMAD2 TGFB1
20 burn scar 10.2 FAS TGFB1
21 odontogenic myxoma 10.2 CD36 MMP1
22 gingival disease 10.2 MMP1 TGFB1
23 burns 10.2
24 blastomycosis 10.2
25 lattice corneal dystrophy 10.2 FAS TGFB1
26 pustulosis palmaris et plantaris 10.1 SMAD7 TGFB1
27 osteofibrous dysplasia 10.1 CD36 TGFB1
28 recessive dystrophic epidermolysis bullosa 10.1 MMP1 TGFB1
29 basal cell carcinoma 1 10.1
30 basal cell carcinoma 10.1
31 dermatitis 10.1
32 peyronie disease 10.1 TGFB1 TGFB3
33 ocular cicatricial pemphigoid 10.1 CD36 TGFB1
34 kashin-beck disease 10.1 FAS MMP1
35 epithelial basement membrane dystrophy 10.1 FAS TGFB1
36 obstructive nephropathy 10.1 SMAD2 SMAD3 TGFB1
37 tuberculoid leprosy 10.1 TGFB1 TGFB3
38 loeys-dietz syndrome 4 10.1 SMAD3 TGFB3
39 pulmonary fibrosis 10.1 SMAD3 SMAD7 TGFB1
40 fibromatosis, gingival, 1 10.1 CD36 MMP1 TGFB1
41 gingival fibromatosis 10.1 CD36 MMP1 TGFB1
42 pemphigus vulgaris, familial 10.0
43 scleroderma, familial progressive 10.0
44 pemphigus vulgaris 10.0
45 herpes zoster 10.0
46 pemphigus 10.0
47 aortic aneurysm, familial thoracic 1 10.0 MMP1 SMAD3
48 spondylocarpotarsal synostosis syndrome 10.0 SMAD2 SMAD3
49 bethlem myopathy 1 10.0
50 insulin-like growth factor i 10.0

Graphical network of the top 20 diseases related to Keloids:



Diseases related to Keloids

Symptoms & Phenotypes for Keloids

MGI Mouse Phenotypes related to Keloids:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.14 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
2 cardiovascular system MP:0005385 10.07 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
3 homeostasis/metabolism MP:0005376 10.06 CD36 FAS MMP1 SMAD2 SMAD3 SMAD7
4 cellular MP:0005384 10.05 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
5 digestive/alimentary MP:0005381 10.02 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
6 hematopoietic system MP:0005397 9.98 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
7 craniofacial MP:0005382 9.97 FAS SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
8 immune system MP:0005387 9.97 CD36 FAS MMP1 SMAD2 SMAD3 SMAD7
9 endocrine/exocrine gland MP:0005379 9.93 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
10 liver/biliary system MP:0005370 9.72 CD36 FAS SMAD2 SMAD3 TGFB1
11 nervous system MP:0003631 9.7 CD36 FAS SMAD2 SMAD3 TGFB1 TGFB3
12 neoplasm MP:0002006 9.65 FAS MMP1 SMAD2 SMAD3 TGFB1
13 skeleton MP:0005390 9.43 CD36 FAS SMAD2 SMAD3 TGFB1 TGFB3
14 vision/eye MP:0005391 9.1 CD36 FAS SMAD2 SMAD3 TGFB1 TGFB3

Drugs & Therapeutics for Keloids

Drugs for Keloids (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 117)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 4,Phase 2 51-21-8 3385
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 124-94-7 31307
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
5
Povidone-iodine Approved Phase 4 25655-41-8
6
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
7
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
8
Ethanol Approved Phase 4 64-17-5 702
9
Tocopherol Approved, Investigational Phase 4 1406-66-2 14986
10
Petrolatum Approved, Investigational Phase 4 8009-03-8
11
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
12
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
13
Allantoin Approved Phase 4 97-59-6 204
14
Tetracaine Approved, Vet_approved Phase 4,Not Applicable 94-24-6 5411
15
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
16
Prilocaine Approved Phase 4 721-50-6 4906
17
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
18
Morphine Approved, Investigational Phase 4 57-27-2 5288826
19
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
20
Verapamil Approved Phase 4 52-53-9 2520
21
Calcium Approved, Nutraceutical Phase 4,Phase 1 7440-70-2 271
22
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
23 Tocotrienol Investigational Phase 4 6829-55-6
24 Antimetabolites Phase 4,Phase 2
25 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 1,Not Applicable
27 Hormones Phase 4,Phase 3,Phase 1,Not Applicable
28 Triamcinolone diacetate Phase 4,Phase 3,Phase 1,Not Applicable
29 Hormone Antagonists Phase 4,Phase 3,Phase 1,Not Applicable
30 Antimetabolites, Antineoplastic Phase 4,Phase 2
31 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1,Not Applicable
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Not Applicable
33 triamcinolone acetonide Phase 4,Phase 3,Phase 1,Not Applicable
34 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 glucocorticoids Phase 4,Phase 3,Phase 1,Not Applicable
36 Anesthetics Phase 4,Not Applicable
37 Anti-Infective Agents Phase 4,Phase 3,Early Phase 1,Not Applicable
38 Emollients Phase 4,Phase 3
39 Calcium, Dietary Phase 4,Phase 1
40 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
41 BB 1101 Phase 4
42 HIV Protease Inhibitors Phase 4
43 Gastrointestinal Agents Phase 4,Not Applicable
44 Antineoplastic Agents, Hormonal Phase 4
45
protease inhibitors Phase 4
46 Autonomic Agents Phase 4
47 Antiemetics Phase 4
48 Micronutrients Phase 4,Early Phase 1
49 Tocopherols Phase 4
50 Hydrocortisone hemisuccinate Phase 4

Interventional clinical trials:

(show top 50) (show all 99)
# Name Status NCT ID Phase Drugs
1 Pilot Study to Evaluate Clinical Outcomes With the Use of Biovance Following Keloid Scar Revision Surgery Unknown status NCT02521402 Phase 4
2 Keloid Scarring: Treatment and Pathophysiology Unknown status NCT01295099 Phase 4 5- fluorouracil;Triamcinolone
3 Surgical Excision and Intralesional Steroid Injection for Prevention of Post Caesarean Keloid Recurrence Completed NCT03239964 Phase 4 Dexamethasone
4 A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars Completed NCT00754247 Phase 4 0.5% hydrocortisone, silicone, vitamin E lotion;Onion extract gel;Cetearyl alcohol lotion
5 Effect of Transparent, Self-drying Silicone Gel on the Treatment of Hypertrophic Abdominal Scars Completed NCT01078428 Phase 4
6 Radiesse® Injectable Dermal Filler for the Treatment of Nasolabial Folds in Persons of Color Completed NCT01012388 Phase 4
7 Treatment of Keloidscars With Intralesional Triamcinolone and 5-fluorouracil Injections-prospective, Randomized, Controlled Trial - Pilot Study Completed NCT02155439 Phase 4 5-fluorouracil;Triamcinolone
8 A Post-Market Study to Evaluate Adverse Event Incidence Rates in Patients With Skin of Color Undergoing Correction of Nasolabial Folds With Hylaform, Hylaform Plus and Captique. Completed NCT00293163 Phase 4
9 Pilot Study of a Novel 532nm KTP Laser for the Treatment of Fresh Surgical Scars Completed NCT01789346 Phase 4
10 Effect of Silicone Gel Versus Contractubex Phonophoresis for Post-burn Hypertrophic Scars Completed NCT03777891 Phase 4
11 7% Lidocaine/7% Tetracaine Cream Versus 2,5% Lidocaine / 2,5% Prilocaine Cream Completed NCT02372786 Phase 4 2,5% lidocaine / 2,5% prilocaine cream;7% lidocaine / 7% tetracaine cream
12 The Efficacy of Laser Assisted Hair Removal in the Treatment of Acne Keloidalis Nuchae; a Pilot Study Completed NCT01548898 Phase 4
13 Facial Lipoatrophy Correction Experience With SCULPTRA ("FACES" Study) Completed NCT00360932 Phase 4
14 Pain Outcomes Following Intralesional Corticosteroid Injections Recruiting NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
15 Use of On-Q Pump for Pain Post C-Section Enrolling by invitation NCT02579629 Phase 4 Ropivacaine 0.1%;Ropivacaine 0.2%;Normal saline
16 Verapamil vs Steroid to Prevent Keloid Recurrence Terminated NCT01720056 Phase 4 Verapamil;Kenalog 10
17 Safety and Efficacy of Infrared Diode Laser on Improvement of Scar and Prevention of Recurrence of Excised Keloid Unknown status NCT01158196 Phase 3
18 Scars After Central Venous Catheters Unknown status NCT01113125 Phase 3 Betamethason-17-valerate and fusidic acid;Fusidic Acid
19 Silicone Gel Versus Onion Extract Gel as Prevention for Postsurgical Scars Unknown status NCT01861119 Phase 3 Silicone gel Kelo-cort™;;Onion extract gel Contractubex™
20 CICATRIX in the Treatment of Hypertrophic Scars and Keloids Scars Completed NCT00993005 Phase 3
21 Efficacy of Intralesional Triamcinolone and 8% Topical Pirfenidone for Treatment of Keloid Scars Recruiting NCT02823236 Phase 3 Topical Pirfenidone;Triamcinolone + Pirfenidone;Intralesional Triamcinolone
22 PRP Use in Diabetic Patients Undergoing Cesarean Section Not yet recruiting NCT03602950 Phase 2, Phase 3
23 A Study to Evaluate the Effectiveness and Safety of RXI-109 on the Outcome of Keloid Excision Surgery in Healthy Adults Completed NCT02079168 Phase 2 RXI-109;Placebo
24 Exploratory Study of the Efficacy and Safety of Juvista 250ng When Administered Following Excision of Ear Lobe Keloids Completed NCT00836147 Phase 1, Phase 2 Avotermin (Juvista);Placebo
25 A Pilot Study of Apligraf for the Treatment and Prevention of Recurrence of Excised Keloids Completed NCT00587587 Phase 1, Phase 2
26 Evaluation of the Initial Safety and Efficacy of Keloid Lesions Treated With MF-4181 Completed NCT01446770 Phase 2
27 Trial of Juvista (Avotermin) Following Removal of Ear Lobe Keloid Scars Completed NCT00469235 Phase 1, Phase 2 Avotermin
28 Safety of Juvista When Administered Following Excision of Ear Lobe Keloids Completed NCT00710333 Phase 1, Phase 2 Avotermin;placebo
29 A Study to Evaluate the Safety and Efficacy of AZX100 Drug Product Following Excision of Keloid Scars Completed NCT00825916 Phase 2 AZX100 Drug Product;AZX100 Drug Product;Placebo
30 A Study to Evaluate the Safety and Efficacy of Additional Doses of AZX100 Drug Product Following Excision of Keloid Scars Completed NCT00892723 Phase 2 AZX100 Drug Product;Placebo;AZX100 Drug Product
31 Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix Completed NCT00129428 Phase 1, Phase 2
32 Study of GBT009 for Treatment of Incisional Wounds Following Breast Reconstruction Surgery Completed NCT01053897 Phase 2
33 Imiquimod for Preventing Keloid Recurrence Recruiting NCT03760250 Phase 2 Imiquimod 5% cream
34 Efficacy, Safety, and Tolerability of MRG-201 Following Intradermal Injection in Subjects With a History of Keloids Recruiting NCT03601052 Phase 2 MRG-201;Placebo
35 Therapy of Scars and Cutis Laxa With Autologous Adipose Derived Mesenchymal Stem Cells Recruiting NCT03887208 Phase 1, Phase 2
36 Light Emitting Diode-Red Light (LED-RL) Phototherapy for Skin Scarring Prevention Recruiting NCT03795116 Phase 2
37 Therapeutic Study of Bevacizumab Injection Directly Inside the Keloid Tissue Terminated NCT01408953 Phase 2
38 Sorafenib for Patients With Extensive Keloids Terminated NCT01425216 Phase 2 Sorafenib
39 Efficacy 2 Part Study of Identification of Keloid Biomarkers and Effect of QAX576 on Keloid Recurrence Terminated NCT00987545 Phase 2 QAX576;QAX576 placebo
40 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts Terminated NCT02705352 Phase 2 5-Fluorouracil
41 Comparison of Dual-mode ER:YAG Laser in Patients With Long Keloid/Hypertrophic Scars Withdrawn NCT02546076 Phase 2
42 Calcium Electroporation for the Treatment of Keloids Unknown status NCT01941914 Phase 1 Calcium chloride
43 Fractional Photothermolysis for the Treatment of Burn Scars Unknown status NCT01005992 Phase 1
44 FS2 Safety and Tolerability Study in Healthy Volunteers Completed NCT02340325 Phase 1 Acute Application of kynurenic acid cream;Chronic application of kynurenic acid cream
45 High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin Completed NCT02630303 Phase 1
46 A Pilot Study of Intralesional Injection of Triamcinolone Acetonide for Desmoid Tumors Recruiting NCT03627741 Phase 1 Triamcinolone Acetonide
47 Phase 1 Study of HF-LED-RL in Fitzpatrick Skin Types I to III Recruiting NCT03433222 Phase 1
48 Study to Evaluate Fractional Collagen Synthesis Within Keloid Scars and Identify Biomarkers of Keloid Scars Terminated NCT01978301 Phase 1 Triamcinolone acetonide;Placebo
49 Evaluation and Comparison of Keloids and Second Degree Burns Blisters Fluid Unknown status NCT01627769
50 Prevention of Hypertrophic Scars or Keloids Unknown status NCT00849004 Not Applicable

Search NIH Clinical Center for Keloids

Genetic Tests for Keloids

Anatomical Context for Keloids

MalaCards organs/tissues related to Keloids:

42
Skin, Breast, Endothelial, Bone, Testes, T Cells, Heart

Publications for Keloids

Articles related to Keloids:

(show top 50) (show all 1888)
# Title Authors Year
1
Botulinum toxin type A for the treatment and prevention of hypertrophic scars and keloids: Updated review. ( 30548742 )
2019
2
Reply to comments on "comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial". ( 30655058 )
2019
3
Efficacy of fractional CO2 laser with intralesional steroid compared with intralesional steroid alone in the treatment of keloids and hypertrophic scars. ( 30770627 )
2019
4
The Efficacy of Combining Fractional Carbon Dioxide Laser With Verapamil Hydrochloride or 5-Fluorouracil in the Treatment of Hypertrophic Scars and Keloids: A Clinical and Immunohistochemical Study. ( 30829753 )
2019
5
Immunohistochemical Expression of Cyclooxygenases in Hypertrophic Scars and Keloids. ( 30881820 )
2019
6
NEDD4 Is Involved in Inflammation Development during Keloid Formation. ( 30273597 )
2019
7
Inactivating the ubiquitin ligase Parkin suppresses cell proliferation and induces apoptosis in human keloids. ( 30784061 )
2019
8
Consensus Guidelines on the Use of Superficial Radiation Therapy for Treating Nonmelanoma Skin Cancers and Keloids. ( 30881578 )
2019
9
miR-96 promotes collagen deposition in keloids by targeting Smad7. ( 30651862 )
2019
10
miR-188-5p regulates proliferation and invasion via PI3K/Akt/MMP-2/9 signaling in keloids. ( 30668826 )
2019
11
Fractionated de-volumizing Keloid tissue - The 'pop' method- A novel technique to facilitate administration of intralesional corticosteroid in difficult keloids. ( 30703450 )
2019
12
Advances in diagnostic methods for keloids and biomarker-targeted fluorescent probes. ( 30734778 )
2019
13
Successful Treatment of Intralesional Bleomycin in Keloids of Vietnamese Population. ( 30745985 )
2019
14
Comparing the Efficacy of Intralesional Triamcinolone Acetonide With Verapamil in Treatment of Keloids: A Randomized Controlled Trial. ( 30775139 )
2019
15
The 1470 nm diode laser with an intralesional fiber device: a proposed solution for the treatment of inflamed and infected keloids. ( 30783604 )
2019
16
Vitiligo at a keloid scar: A possible case of Koebner phenomenon. ( 29923631 )
2019
17
Use of neodymium magnetic discs as pressure earrings for earlobe keloid postexcision. ( 29723556 )
2019
18
A Role for the E3 Ubiquitin Ligase NEDD4 in Keloid Pathogenesis. ( 30471838 )
2019
19
A thermosensitive RGD-modified hydroxybutyl chitosan hydrogel as a 3D scaffold for BMSCs culture on keloid treatment. ( 30529347 )
2019
20
Analysis of Keloid Response to 5-Fluorouracil Treatment and Long-Term Prevention of Keloid Recurrence. ( 30531622 )
2019
21
In vitro analysis of the role of tumor necrosis factor‑stimulated gene‑6 in keloid. ( 30569148 )
2019
22
Tension enhances cell proliferation and collagen synthesis by upregulating expressions of integrin αvβ3 in human keloid-derived mesenchymal stem cells. ( 30597173 )
2019
23
Integrated Interaction Network of MicroRNA Target Genes in Keloid Scarring. ( 30604399 )
2019
24
MicroRNA-152-5p inhibits proliferation and migration and promotes apoptosis by regulating expression of Smad3 in human keloid fibroblasts. ( 30638178 )
2019
25
Combined Therapeutic Strategies for Keloid Treatment. ( 30640767 )
2019
26
Targeting mTORC1/2 with OSI-027 inhibits proliferation and migration of keloid keratinocytes. ( 30650200 )
2019
27
Comparison of Fractional CO2 Laser, Verapamil, and Triamcinolone for the Treatment of Keloid. ( 30705785 )
2019
28
Aligned topography mediated cell elongation reverses pathological phenotype of in vitro cultured keloid fibroblasts. ( 30724474 )
2019
29
Correlation between Serum 25-Hydroxyvitamin D Levels with Keloid Severity. ( 30740162 )
2019
30
Successful Treatment of Intralesional Triamcilonon Acetonide Injection in Keloid Patients. ( 30745979 )
2019
31
Multi-dimensional models for functional testing of keloid scars: In silico, in vitro, organoid, organotypic, ex-vivo organ culture and in vivo models. ( 30761660 )
2019
32
Galectin-1 and Galectin-3 and Their Potential Binding Partners in the Dermal Thickening of Keloid Tissues. ( 30801341 )
2019
33
Chondrocutaneous Bilateral Advancement Flap with Postoperative Radiation Therapy for a Helical Rim Keloid. ( 30805689 )
2019
34
A multimodal therapeutic approach improves the clinical outcome of auricular keloid patients. ( 30809792 )
2019
35
Discussion: Treatment of Keloid Scars with Botulinum Toxin Type A versus Triamcinolone in an Athymic Nude Mouse Model. ( 30817648 )
2019
36
Corneal keloid presenting forty years after penetrating injury: case report and literature review. ( 30849427 )
2019
37
Improving the anti-keloid outcomes through liposomes loading paclitaxel-cholesterol complexes. ( 30863067 )
2019
38
Managing keloid scars: From radiation therapy to actual and potential drug deliveries. ( 30864269 )
2019
39
STAT3 Signaling Pathway is Implicated in Keloid Pathogenesis by Preliminary Transcriptome and Open Chromatin Analyses. ( 30916811 )
2019
40
Radiation Therapy, Keloids ( 29763148 )
2018
41
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ? ( 29240586 )
2018
42
Facial Plastic Surgery Controversies: Keloids. ( 29636144 )
2018
43
Evaluating the Therapeutic Success of Keloids Treated With Cryotherapy and Intralesional Corticosteroids Using Noninvasive Objective Measures. ( 29701618 )
2018
44
Centella asiatica (CentellicumAr) facilitates the regular healing of surgical scars in subjects at high risk of keloids. ( 29623705 )
2018
45
Genomic risk variants at 3q22.3 are associated with keloids in a Chinese Han population. ( 29511450 )
2018
46
The Effects of Postoperative Intralesional Corticosteroids in the Prevention of Recurrent Earlobe Keloids: A Multispecialty Retrospective Review. ( 29381548 )
2018
47
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ? ( 29240593 )
2018
48
Treatment of auricular keloids by triple combination therapy: Surgical excision, platelet-rich plasma, and cryosurgery. ( 29663626 )
2018
49
Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids. ( 29498630 )
2018
50
Comparison of intralesional verapamil versus intralesional corticosteroids in treatment of keloids and hypertrophic scars: A randomized controlled trial. ( 29886113 )
2018

Variations for Keloids

Expression for Keloids

Search GEO for disease gene expression data for Keloids.

Pathways for Keloids

Pathways related to Keloids according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CD36 MMP1 TGFB1 TGFB3 TNC
2
Show member pathways
13.09 FAS SMAD2 SMAD3 TGFB1 TGFB3
3
Show member pathways
12.75 SMAD2 SMAD3 TGFB1 TGFB3
4
Show member pathways
12.72 SMAD2 SMAD3 SMAD7 TGFB1
5 12.71 FAS MMP1 SMAD2 SMAD3 TGFB1 TGFB3
6
Show member pathways
12.66 SMAD2 SMAD3 TGFB1 TGFB3
7
Show member pathways
12.64 MMP1 TGFB1 TGFB3 TNC
8
Show member pathways
12.51 SMAD2 SMAD3 TGFB1 TGFB3
9
Show member pathways
12.4 SMAD2 SMAD3 TGFB1 TGFB3
10 12.3 SMAD2 SMAD3 TGFB1 TGFB3
11 12.29 SMAD2 SMAD3 TGFB1 TGFB3
12
Show member pathways
12.24 SMAD2 SMAD3 SMAD7
13
Show member pathways
12.23 SMAD2 SMAD3 SMAD7 TGFB1
14 12.19 FAS SMAD2 TGFB1
15 12.17 SMAD2 SMAD3 TGFB1 TGFB3
16
Show member pathways
12.12 SMAD2 SMAD3 TGFB1
17 12.1 SMAD2 SMAD3 TGFB1 TGFB3
18 12.06 MMP1 SMAD2 SMAD7
19 12.05 MMP1 SMAD2 SMAD3 TGFB1 TGFB3
20
Show member pathways
12.02 SMAD2 SMAD3 TGFB1 TGFB3
21 11.99 SMAD2 SMAD3 TGFB1 TGFB3
22
Show member pathways
11.99 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
23 11.99 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
24 11.98 FAS SMAD3 TGFB1
25
Show member pathways
11.97 SMAD2 SMAD3 TGFB1 TGFB3
26 11.91 CD36 MMP1 TGFB1
27 11.83 SMAD2 SMAD3 TGFB1 TGFB3
28
Show member pathways
11.82 SMAD2 SMAD3 TGFB1
29 11.8 MMP1 TGFB1 TGFB3
30 11.79 TGFB1 TGFB3 TNC
31 11.72 SMAD2 SMAD3 SMAD7
32 11.7 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
33 11.68 CD36 TGFB1 TGFB3
34 11.65 SMAD2 SMAD3 SMAD7 TGFB1
35 11.63 SMAD2 SMAD3 TGFB1 TGFB3
36
Show member pathways
11.62 SMAD2 SMAD3 SMAD7 TGFB1
37 11.61 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
38 11.57 TGFB1 TGFB3 TNC
39
Show member pathways
11.53 SMAD2 SMAD3 TGFB1 TGFB3
40 11.52 MMP1 SMAD3 TGFB1
41 11.52 SMAD2 SMAD3 SMAD7 TGFB1
42 11.49 CD36 TGFB1 TGFB3
43 11.46 MMP1 SMAD2 SMAD3
44 11.31 MMP1 TNC
45 11.22 MMP1 SMAD2 SMAD3 SMAD7 TGFB1 TNC
46 11.2 SMAD2 SMAD3
47
Show member pathways
11.17 SMAD7 TGFB1 TGFB3
48 11.15 SMAD2 SMAD3 TGFB1 TGFB3
49 11.14 SMAD2 TGFB1 TGFB3
50 11.1 SMAD2 SMAD3

GO Terms for Keloids

Cellular components related to Keloids according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.46 CD36 FAS TGFB1 TGFB3
2 transcription factor complex GO:0005667 9.43 SMAD2 SMAD3 SMAD7
3 SMAD protein complex GO:0071141 8.96 SMAD2 SMAD3
4 heteromeric SMAD protein complex GO:0071144 8.62 SMAD2 SMAD3

Biological processes related to Keloids according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.98 SMAD2 SMAD3 TGFB1 TGFB3
2 positive regulation of gene expression GO:0010628 9.97 CD36 SMAD2 SMAD3 TGFB1 TNC
3 protein deubiquitination GO:0016579 9.91 SMAD2 SMAD3 SMAD7
4 negative regulation of gene expression GO:0010629 9.91 CD36 SMAD2 TGFB1
5 in utero embryonic development GO:0001701 9.88 SMAD2 SMAD3 TGFB3
6 regulation of cell proliferation GO:0042127 9.87 TGFB1 TGFB3 TNC
7 response to hypoxia GO:0001666 9.87 SMAD3 TGFB1 TGFB3
8 platelet degranulation GO:0002576 9.85 CD36 TGFB1 TGFB3
9 cellular response to transforming growth factor beta stimulus GO:0071560 9.78 SMAD3 SMAD7 TGFB1
10 SMAD protein signal transduction GO:0060395 9.78 SMAD2 SMAD3 TGFB1 TGFB3
11 extrinsic apoptotic signaling pathway GO:0097191 9.75 FAS SMAD3 TGFB1
12 positive regulation of protein secretion GO:0050714 9.73 TGFB1 TGFB3
13 embryonic cranial skeleton morphogenesis GO:0048701 9.73 SMAD2 SMAD3
14 gastrulation GO:0007369 9.73 SMAD2 SMAD3
15 positive regulation of bone mineralization GO:0030501 9.73 SMAD3 TGFB1 TGFB3
16 mammary gland development GO:0030879 9.72 TGFB1 TGFB3
17 negative regulation of mitotic cell cycle GO:0045930 9.72 SMAD3 TGFB1
18 response to progesterone GO:0032570 9.72 TGFB1 TGFB3
19 digestive tract development GO:0048565 9.72 TGFB1 TGFB3
20 mesoderm formation GO:0001707 9.72 SMAD2 SMAD3
21 positive regulation of protein import into nucleus GO:0042307 9.71 SMAD3 TGFB1
22 face morphogenesis GO:0060325 9.71 TGFB1 TGFB3
23 developmental growth GO:0048589 9.71 SMAD2 SMAD3
24 positive regulation of epithelial to mesenchymal transition GO:0010718 9.71 SMAD2 SMAD3 TGFB1 TGFB3
25 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.7 SMAD3 TGFB1
26 positive regulation of collagen biosynthetic process GO:0032967 9.7 TGFB1 TGFB3
27 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.7 SMAD7 TGFB1
28 adrenal gland development GO:0030325 9.69 SMAD2 SMAD3
29 endoderm development GO:0007492 9.69 SMAD2 SMAD3 TGFB1
30 embryonic pattern specification GO:0009880 9.68 SMAD2 SMAD3
31 signal transduction involved in regulation of gene expression GO:0023019 9.68 SMAD2 SMAD3
32 activin receptor signaling pathway GO:0032924 9.68 SMAD2 SMAD3
33 secondary palate development GO:0062009 9.67 SMAD2 TGFB3
34 lens fiber cell differentiation GO:0070306 9.67 SMAD3 TGFB1
35 cell-cell junction organization GO:0045216 9.67 SMAD3 TGFB1 TGFB3
36 ureteric bud development GO:0001657 9.67 SMAD2 SMAD3 SMAD7 TGFB1
37 pathway-restricted SMAD protein phosphorylation GO:0060389 9.66 SMAD7 TGFB1
38 positive regulation of SMAD protein signal transduction GO:0060391 9.66 TGFB1 TGFB3
39 nodal signaling pathway GO:0038092 9.65 SMAD2 SMAD3
40 primary miRNA processing GO:0031053 9.65 SMAD2 SMAD3
41 response to cholesterol GO:0070723 9.65 SMAD2 TGFB1
42 transforming growth factor beta receptor signaling pathway GO:0007179 9.65 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
43 salivary gland morphogenesis GO:0007435 9.64 TGFB1 TGFB3
44 embryonic foregut morphogenesis GO:0048617 9.63 SMAD2 SMAD3
45 pericardium development GO:0060039 9.63 SMAD2 SMAD3
46 response to laminar fluid shear stress GO:0034616 9.63 SMAD7 TGFB1 TGFB3
47 common-partner SMAD protein phosphorylation GO:0007182 9.62 SMAD2 TGFB1
48 negative regulation of macrophage cytokine production GO:0010936 9.62 TGFB1 TGFB3
49 positive regulation of extracellular matrix assembly GO:1901203 9.61 SMAD3 TGFB1
50 SMAD protein complex assembly GO:0007183 9.61 SMAD2 SMAD3 TGFB1

Molecular functions related to Keloids according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.8 SMAD2 SMAD3 TGFB1 TGFB3
2 R-SMAD binding GO:0070412 9.51 SMAD2 SMAD3
3 transforming growth factor beta binding GO:0050431 9.48 CD36 TGFB3
4 enhancer binding GO:0035326 9.46 SMAD2 SMAD3
5 co-SMAD binding GO:0070410 9.43 SMAD2 SMAD3
6 I-SMAD binding GO:0070411 9.4 SMAD2 SMAD7
7 primary miRNA binding GO:0070878 9.37 SMAD2 SMAD3
8 type II transforming growth factor beta receptor binding GO:0005114 9.32 TGFB1 TGFB3
9 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.26 SMAD2 SMAD3
10 transforming growth factor beta receptor binding GO:0005160 9.26 SMAD2 SMAD3 TGFB1 TGFB3
11 type III transforming growth factor beta receptor binding GO:0034714 9.16 TGFB1 TGFB3
12 type I transforming growth factor beta receptor binding GO:0034713 8.92 SMAD2 SMAD7 TGFB1 TGFB3

Sources for Keloids

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17 EFO
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