Keratinizing Squamous Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: KRT003 MIFTS: 41	Keratinizing Squamous Cell Carcinoma Categories: Cancer diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Keratinizing Squamous Cell Carcinoma

MalaCards integrated aliases for Keratinizing Squamous Cell Carcinoma:

Name: Keratinizing Squamous Cell Carcinoma ¹¹ ¹⁴ ¹⁶

Squamous Cell Carcinoma, Keratinizing ¹¹ ⁷¹

Keratinizing Epidermoid Carcinoma ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:5521

NCIt ⁴⁹ C4105

SNOMED-CT ⁶⁸ 18048008

EFO ¹⁶ EFO_0000559

UMLS ⁷¹ C0334247

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Summaries for Keratinizing Squamous Cell Carcinoma

Disease Ontology: ¹¹ A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris.

MalaCards based summary: Keratinizing Squamous Cell Carcinoma, also known as squamous cell carcinoma, keratinizing, is related to basaloid squamous cell carcinoma and transitional cell carcinoma. An important gene associated with Keratinizing Squamous Cell Carcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Endometrial cancer and Malignant pleural mesothelioma. The drugs Amifostine and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include cervix, lymph node and endothelial, and related phenotypes are Decreased viability and Increased transferrin (TF) endocytosis (mild increase), increased transferrin (TF) endosome elongation

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Related Diseases for Keratinizing Squamous Cell Carcinoma

Diseases related to Keratinizing Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 622)

#	Related Disease	Score	Top Affiliating Genes
1	basaloid squamous cell carcinoma	31.4	TP53 SYP NUTM1 NKX2-1 NAPSA KRT7
2	transitional cell carcinoma	30.2	TP53 KRT7 EGFR CDH1
3	adenoid squamous cell carcinoma	30.1	TP53 KRT7 KRT5 CEACAM5 CDH1
4	keratoacanthoma	29.9	TP53 PIK3CA EGFR CDH1
5	breast ductal carcinoma	29.9	TP53 SYP KRT7 KRT5 EGFR CDH1
6	cervical squamous cell carcinoma	29.8	TP53 PIK3CA EGFR CEACAM5 CDKN2A CDH1
7	skin squamous cell carcinoma	29.7	TP53 KRT5 HRAS EGFR CDKN2A CDH1
8	vulva squamous cell carcinoma	29.7	TP53 PIK3CA HRAS EGFR CDKN2A
9	ductal carcinoma in situ	29.7	TP53 PIK3CA KRT5 EGFR CDKN2A CDH1
10	nasopharyngeal carcinoma	29.5	TP53 PSMB9 PIK3CA EGFR CDKN2A CDH1
11	gallbladder adenocarcinoma	29.3	TP53 SYP KRT7 HRAS CEACAM5 CDX2
12	squamous cell carcinoma	29.2	TP53 PIK3CA NKX2-1 KRT7 HRAS EGFR
13	head and neck cancer	29.2	TP53 PIK3CA HRAS EGFR CDKN2A CDH1
14	squamous cell carcinoma, head and neck	29.1	TP53 PIK3CA HRAS EGFR CDKN2A CDH1
15	vulva cancer	29.0	TP53 PIK3CA KRT7 HRAS EGFR CEACAM5
16	adenoma	28.6	TP53 SYP PIK3CA KRT7 HRAS CDX2
17	cervix carcinoma	28.4	TP53 TAAR6 PIK3CA KRT7 HRAS EGFR
18	gallbladder cancer	28.3	TP53 PIK3CA KRT7 HRAS EGFR CEACAM5
19	vulvar keratinizing squamous cell carcinoma	11.6
20	cervical keratinizing squamous cell carcinoma	11.6
21	cervical non-keratinizing squamous cell carcinoma	11.6
22	vulvar non-keratinizing squamous cell carcinoma	11.5
23	penile urethral cancer	10.4	KRT5 CDKN2A
24	cervical basaloid squamous cell carcinoma	10.4	KRT7 CDKN2A
25	adenosquamous breast carcinoma	10.4	TP53 KRT5
26	lymphoepithelioma-like thymic carcinoma	10.4	NUTM1 KRT5
27	basaloid lung carcinoma	10.4	TP53 KRT5
28	laryngeal adenoid cystic carcinoma	10.4	KRT7 KRT5
29	b-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	10.4	TP53 CDKN2A
30	microinvasive cervical squamous cell carcinoma	10.4	KRT7 KRT5
31	ceruminoma	10.4	KRT7 KRT5
32	tonsillar pillar cancer	10.4	EGFR CDKN2A
33	subareolar duct papillomatosis	10.4	KRT7 KRT5
34	prostatic urethral cancer	10.4	KRT7 KRT5
35	atrophic vulva	10.4	KRT7 CDKN2A
36	nipple benign neoplasm	10.3	KRT7 KRT5
37	rete testis neoplasm	10.3	KRT7 KRT5
38	adenosquamous gallbladder carcinoma	10.3	KRT7 KRT5
39	rete testis adenocarcinoma	10.3	KRT7 KRT5
40	breast mucoepidermoid carcinoma	10.3	KRT7 KRT5
41	ovarian mucinous cystadenofibroma	10.3	SYP KRT7
42	mucinous cystadenofibroma	10.3	SYP KRT7
43	ovarian mucinous adenofibroma	10.3	SYP KRT7
44	cloacogenic carcinoma	10.3	SYP KRT5
45	ceruminous adenocarcinoma	10.3	KRT7 KRT5
46	lung meningioma	10.3	SYP NKX2-1
47	posterior pituitary gland neoplasm	10.3	SMARCB1 NKX2-1
48	gastric squamous cell carcinoma	10.3	KRT7 KRT5
49	vagina leiomyoma	10.3	CEACAM5 CDKN2A
50	bile duct mucinous adenocarcinoma	10.3	TP53 SYP

Graphical network of the top 20 diseases related to Keratinizing Squamous Cell Carcinoma:

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Symptoms & Phenotypes for Keratinizing Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

²⁵ (show all 11)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-1	10.07	EGFR HRAS PIK3CA
2	Decreased viability	GR00055-A-2	10.07	EGFR HRAS PIK3CA
3	Decreased viability	GR00221-A-1	10.07	CDH1 CDKN2A EGFR HRAS PIK3CA SMARCB1
4	Decreased viability	GR00221-A-2	10.07	HRAS PIK3CA SMARCB1
5	Decreased viability	GR00221-A-3	10.07	CDKN2A HRAS SMARCB1
6	Decreased viability	GR00221-A-4	10.07	CDKN2A EGFR PIK3CA
7	Decreased viability	GR00249-S	10.07	SMARCB1
8	Decreased viability	GR00301-A	10.07	CDH1
9	Decreased viability	GR00381-A-1	10.07	SMARCB1
10	Decreased viability	GR00402-S-2	10.07	CDH1 PIK3CA
11	Increased transferrin (TF) endocytosis (mild increase), increased transferrin (TF) endosome elongation	GR00363-A	8.32	HRAS

MGI Mouse Phenotypes related to Keratinizing Squamous Cell Carcinoma:

⁴⁵ (show all 11)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.25	CDH1 CDKN2A CDX2 CEACAM5 EGFR HRAS
2	neoplasm	MP:0002006	10.24	CDH1 CDKN2A CDX2 CEACAM5 EGFR HRAS
3	growth/size/body region	MP:0005378	10.22	ARL2BP CDH1 CDKN2A CDX2 CEACAM5 EGFR
4	endocrine/exocrine gland	MP:0005379	10.07	CDH1 CDKN2A CDX2 CEACAM5 EGFR HRAS
5	muscle	MP:0005369	10.06	CDKN2A CEACAM5 EGFR HRAS PIK3CA PSMB9
6	digestive/alimentary	MP:0005381	10.06	CDH1 CDKN2A CDX2 CEACAM5 EGFR HRAS
7	cellular	MP:0005384	10.03	ARL2BP CDH1 CDKN2A CDX2 CEACAM5 EGFR
8	no phenotypic analysis	MP:0003012	10.02	CDH1 CDKN2A EGFR HRAS NKX2-1 PIK3CA
9	cardiovascular system	MP:0005385	9.85	CDH1 CDKN2A CDX2 CEACAM5 EGFR HRAS
10	reproductive system	MP:0005389	9.65	ARL2BP CDH1 CDKN2A CDX2 EGFR NKX2-1
11	skeleton	MP:0005390	9.28	ARL2BP CDKN2A CDX2 EGFR HRAS NKX2-1

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Drugs & Therapeutics for Keratinizing Squamous Cell Carcinoma

Drugs for Keratinizing Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Amifostine

Approved, Investigational

Phase 3

20537-88-6

2141

Fluorouracil

Approved

Phase 3

51-21-8

3385

Cisplatin

Approved

Phase 3

15663-27-1

2767 5702198 441203

Carboplatin

Approved

Phase 3

41575-94-4

10339178 38904

Nivolumab

Approved

Phase 3

946414-94-4

Gemcitabine

Approved

Phase 3

95058-81-4, 122111-03-9

60750

Radiation-Protective Agents

Phase 3

Protective Agents

Phase 3

Antineoplastic Agents, Immunological

Phase 3

Immunologic Factors

Phase 3

Antimetabolites

Phase 3

Immunosuppressive Agents

Phase 3

Antiviral Agents

Phase 3

Anti-Infective Agents

Phase 3

Immune Checkpoint Inhibitors

Phase 3

Cetuximab

Approved

Phase 2

205923-56-4

Bevacizumab

Approved, Investigational

Phase 2

216974-75-3

135329020

Sirolimus

Approved, Investigational

Phase 2

53123-88-9

5284616 6436030

Miconazole

Approved, Investigational, Vet_approved

Phase 2

22916-47-8

4189

Clotrimazole

Approved, Vet_approved

Phase 2

23593-75-1

2812

Cediranib

Investigational

Phase 2

288383-20-0

9933475

Maleic acid

Experimental, Investigational

Phase 2

110-16-7, 110-17-8

444266 444972

Immunoglobulins, Intravenous

Phase 2

Immunoglobulins

Phase 2

Antibodies, Monoclonal

Phase 2

Antibodies

Phase 2

Immunoglobulin G

Phase 2

Angiogenesis Inhibitors

Phase 2

Endothelial Growth Factors

Phase 2

Mitogens

Phase 2

Protein Kinase Inhibitors

Phase 2

Anti-Bacterial Agents

Phase 2

Antifungal Agents

Phase 2

Antibiotics, Antitubercular

Phase 2

Lenalidomide

Approved

Phase 1

191732-72-6

216326

Vorinostat

Approved, Investigational

Phase 1

149647-78-9

5311

Azacitidine

Approved, Investigational

Phase 1

320-67-2

9444

Histone Deacetylase Inhibitors

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Treatment of Childhood Nasopharyngeal Carcinoma With Neoadjuvant Chemotherapy and Concomitant Chemoradiotherapy: A Groupwide Phase III Study	Completed	NCT00274937	Phase 3	Amifostine;Cisplatin;Fluorouracil
2	An Open-Label, Phase III Study of Platinum-Gemcitabine With or Without Nivolumab in the First-Line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma	Active, not recruiting	NCT04458909	Phase 3	Carboplatin;Cisplatin;Gemcitabine
3	A Randomized, Phase II Study of Ficlatuzumab With or Without Cetuximab in Patients With Cetuximab-Resistant, Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma	Completed	NCT03422536	Phase 2	Ficlatuzumab
4	A Phase II Study of Concurrent Chemoradiotherapy Using Three-Dimensional Conformal Radiotherapy (3D-CRT) or Intensity-Modulated Radiation Therapy (IMRT) + Bevacizumab (BV) for Locally or Regionally Advanced Nasopharyngeal Cancer	Completed	NCT00408694	Phase 2	Cisplatin;Fluorouracil
5	Phase II Clinical Trial of AZD2171 Monotherapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Patients	Completed	NCT00458978	Phase 2	Cediranib Maleate
6	A T1 Translational Multicenter Randomized Phase II Study of Temsirolimus Versus Cetuximab Plus Temsirolimus in Patients With Recurrent / Metastatic Head and Neck Cancer, Who Failed Prior EGFR Based Therapy	Completed	NCT01256385	Phase 2	Temsirolimus
7	Enhancement of Cetuximab-Induced Antibody-Dependent Cellular Cytotoxicity (ADCC) With Lenalidomide in Advanced Solid Tumors: A Phase I/IB Study	Completed	NCT01254617	Phase 1	Lenalidomide
8	A Phase I Trial of 5Azacitidine and Suberoylanilide Hydroxamic Acid in Patients With Metastatic or Locally Recurrent Nasopharyngeal Carcinoma and Nasal NK-T Cell Lymphoma	Active, not recruiting	NCT00336063	Phase 1	Azacitidine;Vorinostat
9	Phase I Dose Escalation Study of Stereotactic Body Radiotherapy for Carcinoma of the Head and Neck in High Risk Patients Who Are Ineligible/Refuse Standard of Care Therapy	Terminated	NCT02388932

Search NIH Clinical Center for Keratinizing Squamous Cell Carcinoma

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Genetic Tests for Keratinizing Squamous Cell Carcinoma

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Anatomical Context for Keratinizing Squamous Cell Carcinoma

Organs/tissues related to Keratinizing Squamous Cell Carcinoma:

MalaCards : Cervix, Lymph Node, Endothelial, Lung, Thymus, Trachea, Skin

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Publications for Keratinizing Squamous Cell Carcinoma

Articles related to Keratinizing Squamous Cell Carcinoma:

(show top 50) (show all 277)

#	Title	Authors	PMID	Year
1	Survival comparison of different histological subtypes of oropharyngeal squamous cell carcinoma: A propensity-matched score analysis based on SEER database. ⁶²	Li T...Chen C	36317416	2022
2	Condyloma acuminatum of the urinary tract demonstrates atypical squamous cells in urine cytology. ⁶²	Velez Torres JM...Kryvenko ON	36244465	2022
3	Solitary rib metastasis from primary nasopharyngeal carcinoma: A rare clinical presentation. ⁶²	Abrar S...Abbasi AN	36280995	2022
4	Cuneiform (cuniculatum) variant of oral squamous cell carcinoma revisited: Presentation of two cases and literature review of a rare entity. ⁶²	Beute JE...Urken ML	35064717	2022
5	High-risk HPV Does not Appear to be an Important Risk Factor for Sinonasal Carcinomas in Turkish Population: A Tertiary Center Experience. ⁶²	Apaydin Arikan E...Ozluk Y	35404169	2022
6	Retrospective analysis of clinical features and prognosis of nasopharyngeal carcinoma in children and adolescents. ⁶²	Gong T...Lu J	36186630	2022
7	Re-irradiation with Moderate Hypo-fractionation Using Intensity Modulated Photon or Proton Radiation Therapy in Locally Recurrent Squamous Cell Carcinoma of Nasopharynx. ⁶²	Nam H...Noh JM	33781049	2022
8	Detection of a second primary cancer in a 18F-fluorocholine PET/CT - multicentre retrospective analysis on a group of 1345 prostate cancer patients. ⁶²	Cegla P...Czepczynski R	35137934	2022
9	A Novel Prognostic Risk Model for Cervical Cancer Based on Immune Checkpoint HLA-G-Driven Differentially Expressed Genes. ⁶²	Xu HH...Wang XQ	35924232	2022
10	Underdiagnosis of early cervical cancer with an invisible cervical transformation zone in an elderly patient: A case report. ⁶²	Ishikawa M...Kyo S	34671469	2021
11	Oropharyngeal Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN): A Case Report and Literature Review. ⁶²	Robinson L...van Heerden WFP	33709305	2021
12	A Poorly Differentiated Non-keratinizing Sinonasal Squamous Cell Carcinoma with a Novel ETV6-TNFRSF8 Fusion Gene. ⁶²	Bubola J...Dickson BC	33394379	2021
13	Thymic cancer: A not-so-indolent cause of pericardial effusion. ⁶²	Whiting A...Song D	34659744	2021
14	Value of 18F-FDG PET/CT for Assessment of Advanced Lacrimal Sac Non-Keratinizing Squamous Cell Carcinoma Successfully Treated with Concurrent Chemoradiotherapy. ⁶²	Liao CY...Lin YH	34829312	2021
15	Notably small bronchial carcinoid accompanied by peripheral squamous cell carcinoma. ⁶²	Miura H...Yamamoto T	34589229	2021
16	Carcinomatous-like mastitis due to axillary lymphadenopathy in a case of nasopharyngeal carcinoma: A case report. ⁶²	Oprean CM...Bredicean AC	34373712	2021
17	EGFR Protein Expression Relates with Tumor Histology, Methylation Status of EGFR and HPV16 E6 Viral Load in Oropharyngeal Carcinoma. ⁶²	Suzuki Y...Ikeda K	33428063	2021
18	Malignant pleural neoplasm with both differentiation of epithelioid mesothelioma and squamous-cell carcinoma, a rare phenomena. ⁶²	Re A...Ren S	33347735	2021
19	Descriptive epidemiology of nasopharyngeal carcinoma at Tikur Anbessa Hospital, Ethiopia. ⁶²	Beyene ET...Gebremariam TA	33980204	2021
20	[Extracranial/intracranial vascular bypass to control carotid artery blowout in postirradiated nasopharyngeal carcinoma patients]. ⁶²	Wu P...Raymond King YT	34304473	2021
21	Rectal Squamous Cell Cancer. ⁶²	Nibir IL...Bollinger JW	34159035	2021
22	A case of human papillomavirus infection and vulvar cancer in a young patient - "hit and run" theory. ⁶²	Kostov S...Yordanov A	33869714	2021
23	Metastatic Patterns and Prognosis of de novo Metastatic Nasopharyngeal Carcinoma in the United States. ⁶²	Xu Y...Chen J	32833262	2021
24	Clinical and Pathologic Presentation of Primary Ocular Surface Tumors among Zambians. ⁶²	Julius P...Angeletti PC	33869164	2021
25	Tonsillar p16-Positive Follicular Dendritic Cell Sarcoma Mimicking HPV-Related Oropharyngeal Squamous Cell Carcinoma: A Case Report and Review of Reported Cases. ⁶²	Hutchison B...Faquin WC	32189159	2021
26	A Rare Case of Invasive Keratinizing Squamous Cell Carcinoma of the Foot. ⁶²	Sahu KK...Mohan V	34113181	2021
27	Oropharyngeal carcinoma: A single institution study of 338 primaries with special reference to high-risk human papillomavirus-mediated carcinoma with aggressive behavior. ⁶²	Alexiev BA...Samant S	33113454	2020
28	Tumor Embolism Through Right-to-Left Shunt Due to Venous Invasion of Esophageal Carcinoma. ⁶²	Araki S...Miya F	33010722	2020
29	Image-guided interstitial brachytherapy boost for keratinizing squamous cell carcinoma of inferior wall of the nasopharynx. ⁶²	Murakami N...Itami J	33299579	2020
30	Nonkeratinizing Nasopharyngeal Carcinoma, Undifferentiated Type With Trisomy 2: A Case Report and Short Review of Cytogenetic and Molecular Literature. ⁶²	Pontoriero F...Bajaj R	32755442	2020
31	Telangiectatic Squamous Cell Carcinoma of Uterine Cervix: A Previously Undescribed Variant of Squamous Cell Carcinoma. ⁶²	Jha S...Adhya AK	31651557	2020
32	[Teicoplanin-induced hypersensitivity syndrome in a diabetic foot patient with malignant ulcer]. ⁶²	Shao JM...Han CM	32829619	2020
33	EGFR and αvβ6 as Promising Targets for Molecular Imaging of Cutaneous and Mucosal Squamous Cell Carcinoma of the Head and Neck Region. ⁶²	Baart VM...Cohen D	32516897	2020
34	SMARCB1 (INI-1)-Deficient Adenocarcinoma of the Sinonasal Tract: A Potentially Under-Recognized form of Sinonasal Adenocarcinoma with Occasional Yolk Sac Tumor-Like Features. ⁶²	Shah AA...Bishop JA	31468350	2020
35	Upper Gastrointestinal Bleeding Due to a Duodenal Metastasis from Primary Testicular Squamous Cell Carcinoma. ⁶²	Gonzalez JJ...Reichert ZR	32392185	2020
36	Survival comparison of Three histological subtypes of lung squamous cell carcinoma: A population-based propensity score matching analysis. ⁶²	An N...Chen Z	32062199	2020
37	Histological subtype remains a prognostic factor for survival in nasopharyngeal carcinoma patients. ⁶²	Pan XX...Li CR	31188486	2020
38	Cervical Cancer Care Continuum in South India: Evidence from a Community-based Screening Program. ⁶²	Vidhubala E...Mahadevan S	32175707	2020
39	Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study. ⁶²	Ogun GO...Nwaorgu OG	32774641	2020
40	Comparative study on the mutational profile of adenocarcinoma and squamous cell carcinoma predominant histologic subtypes in Chinese non-small cell lung cancer patients. ⁶²	Ding Y...Zhang Z	31692283	2020
41	Comprehensive Molecular Characterizations of Chinese Patients With Different Subtypes of Lung Squamous Cell Carcinoma. ⁶²	Qian J...Yu Y	33363036	2020
42	The effect of histological subtypes on survival outcome in nasopharyngeal carcinoma after extensive follow up. ⁶²	Wu SG...He ZY	32042784	2019
43	Phase I trial of belinostat in combination with 13-cis-retinoic acid in advanced solid tumor malignancies: a California Cancer Consortium NCI/CTEP sponsored trial. ⁶²	Luu T...Newman EM	31522242	2019
44	Lymph Node Status and Outcomes for Nasopharyngeal Carcinoma According to Histological Subtypes: A SEER Population-Based Retrospective Analysis. ⁶²	Guo R...Wu SG	31559602	2019
45	Adenoid Basal Carcinoma of the Uterine Cervix in Association with Keratinizing Squamous Cell Carcinoma: a Rare Diagnosis. ⁶²	Pathak P...Tanveer N	31496589	2019
46	Nasopharyngeal undifferentiated carcinoma with sarcomatoid features: Pitfalls in the immunohistochemistry. ⁶²	Lee M...Yu IK	31427557	2019
47	Molecular profile of tongue cancer in an 18-year-old female patient with no recognizable risk factor. ⁶²	Ambele MA...van Heerden WFP	31236464	2019
48	Radiation therapy for vaginal cancer in complete uterine prolapse with intrauterine adhesion: a case report. ⁶²	Ishibashi N...Okada M	31122220	2019
49	Lung squamous cell carcinoma: A postoperative recurrence analysis of keratinizing and nonkeratinizing subtypes. ⁶²	Chen R...Yu Y	30389303	2019
50	Rapid Progression of Intracranial Dural Metastases in a Patient with Carcinoma of Unknown Primary Site. ⁶²	Takeda H...Yoshioka T	31572156	2019

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Genes for Keratinizing Squamous Cell Carcinoma

Genes related to Keratinizing Squamous Cell Carcinoma (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	6.2	DISEASES inferred ¹⁴
2	KRT5	Keratin 5	Protein Coding	6.11	DISEASES inferred ¹⁴
3	NUTM1	NUT Midline Carcinoma Family Member 1	Protein Coding	5.61	DISEASES inferred ¹⁴
4	TP53	Tumor Protein P53	Protein Coding	5.56	DISEASES inferred ¹⁴
5	NKX2-1	NK2 Homeobox 1	Protein Coding	5.38	DISEASES inferred ¹⁴
6	KRT7	Keratin 7	Protein Coding	5.22	DISEASES inferred ¹⁴
7	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	5.21	DISEASES inferred ¹⁴
8	SYP	Synaptophysin	Protein Coding	5.13	DISEASES inferred ¹⁴
9	EGFR	Epidermal Growth Factor Receptor	Protein Coding	5.05	DISEASES inferred ¹⁴
10	PSMB9	Proteasome 20S Subunit Beta 9	Protein Coding	4.58	DISEASES inferred ¹⁴
11	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	4.58	DISEASES inferred ¹⁴
12	CDH1	Cadherin 1	Protein Coding	4.57	DISEASES inferred ¹⁴
13	TAAR6	Trace Amine Associated Receptor 6	Protein Coding	4.57	DISEASES inferred ¹⁴
14	NAPSA	Napsin A Aspartic Peptidase	Protein Coding	4.54	DISEASES inferred ¹⁴
15	CDX2	Caudal Type Homeobox 2	Protein Coding	4.52	DISEASES inferred ¹⁴
16	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	4.5	DISEASES inferred ¹⁴
17	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	4.49	DISEASES inferred ¹⁴
18	ARL2BP	ADP Ribosylation Factor Like GTPase 2 Binding Protein	Protein Coding	4.47	DISEASES inferred ¹⁴

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Variations for Keratinizing Squamous Cell Carcinoma

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Expression for Keratinizing Squamous Cell Carcinoma

Search GEO for disease gene expression data for Keratinizing Squamous Cell Carcinoma.

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Pathways for Keratinizing Squamous Cell Carcinoma

Pathways related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 26)

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.47	TP53 PIK3CA HRAS EGFR CDKN2A CDH1
2	Malignant pleural mesothelioma ⁷⁴	12.41	CDH1 CDKN2A EGFR HRAS PIK3CA TP53
3	Hepatocyte growth factor receptor signaling ⁷⁴ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development HGF signaling pathway ²² Development Neurotrophin family signaling ²² Drug-mediated inhibition of MET activation ⁶⁶ MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ PLC-gamma1 signalling ⁶⁶ Trk receptor signaling mediated by PI3K and PLC-gamma ⁶¹ TRKA activation by NGF ⁶⁶	12.33	TP53 PIK3CA HRAS CDH1
4	Breast cancer pathway ⁷⁴ Show member pathways Embryonic stem cell pluripotency pathways ⁷⁴	12.32	TP53 PIK3CA HRAS EGFR
5	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ⁶¹	12.32	TP53 PIK3CA HRAS EGFR CDH1
6	NF-kappaB Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ Apoptosis Pathway ⁷⁰	12.27	TP53 PIK3CA HRAS EGFR
7	MAPK Signaling: Mitogens ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	12.09	TP53 PIK3CA HRAS EGFR
8	Epithelial to mesenchymal transition in colorectal cancer ⁷⁴	11.98	TP53 PIK3CA HRAS CDH1
9	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	11.94	TP53 PIK3CA HRAS CDKN2A
10	Senescence and autophagy in cancer ⁷⁴	11.83	TP53 HRAS CDKN2A
11	DNA damage response (only ATM dependent) ⁷⁴	11.8	TP53 PIK3CA HRAS
12	Signaling by EGFR ⁶⁶ Show member pathways EGFR downregulation ⁶⁶ GAB1 signalosome ⁶⁶	11.78	PIK3CA HRAS EGFR
13	Thyroid hormones production and peripheral downstream signaling effects ⁷⁴	11.68	HRAS PIK3CA TP53
14	mTOR Pathway ⁷⁰ Show member pathways TGF-beta Pathway ⁷⁰	11.62	TP53 PIK3CA HRAS
15	Gastrin signaling pathway ⁷⁴	11.6	PIK3CA HRAS EGFR CDKN2A CDH1
16	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ⁶¹	11.56	PIK3CA HRAS CDH1
17	Pathways affected in adenoid cystic carcinoma ⁷⁴	11.49	TP53 PIK3CA HRAS
18	Pre-implantation embryo ⁷⁴	11.45	NKX2-1 CDX2 CDH1
19	Posttranslational regulation of adherens junction stability and dissassembly ⁶¹	11.35	CDH1 EGFR HRAS
20	Head and neck squamous cell carcinoma ⁷⁴	11.22	TP53 PIK3CA HRAS EGFR CDKN2A
21	Transcription_Transcription factor Tubby signaling pathways ²²	11.21	TP53 HRAS EGFR
22	a6b1 and a6b4 Integrin signaling ⁶¹	11.13	PIK3CA HRAS EGFR CDH1
23	E-cadherin signaling in keratinocytes ⁶¹	10.84	PIK3CA EGFR CDH1
24	Bladder cancer ⁷⁴	10.62	TP53 HRAS EGFR CDKN2A CDH1
25	Relationship between inflammation, COX-2 and EGFR ⁷⁴	10.58	PIK3CA EGFR
26	Mammary gland development pathway - Involution (Stage 4 of 4) ⁷⁴	10.57	TP53 CDH1

Sources

GO Terms for Keratinizing Squamous Cell Carcinoma

Cellular components related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	germ cell nucleus	GO:0043073	8.92	TP53 SMARCB1

Biological processes related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of DNA-templated transcription	GO:0045893	9.4	TP53 NKX2-1 EGFR CDX2 CDKN2A CDH1
2	positive regulation of miRNA maturation	GO:1903800	8.96	TP53 EGFR