MCID: KRT003
MIFTS: 41

Keratinizing Squamous Cell Carcinoma

Categories: Cancer diseases, Skin diseases
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Aliases & Classifications for Keratinizing Squamous Cell Carcinoma

MalaCards integrated aliases for Keratinizing Squamous Cell Carcinoma:

Name: Keratinizing Squamous Cell Carcinoma 11 14 16
Squamous Cell Carcinoma, Keratinizing 11 71
Keratinizing Epidermoid Carcinoma 11

Classifications:



External Ids:

Disease Ontology 11 DOID:5521
NCIt 49 C4105
SNOMED-CT 68 18048008
UMLS 71 C0334247

Summaries for Keratinizing Squamous Cell Carcinoma

Disease Ontology: 11 A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris.

MalaCards based summary: Keratinizing Squamous Cell Carcinoma, also known as squamous cell carcinoma, keratinizing, is related to basaloid squamous cell carcinoma and transitional cell carcinoma. An important gene associated with Keratinizing Squamous Cell Carcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Endometrial cancer and Malignant pleural mesothelioma. The drugs Amifostine and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include cervix, lymph node and endothelial, and related phenotypes are Decreased viability and Increased transferrin (TF) endocytosis (mild increase), increased transferrin (TF) endosome elongation

Related Diseases for Keratinizing Squamous Cell Carcinoma

Diseases related to Keratinizing Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 622)
# Related Disease Score Top Affiliating Genes
1 basaloid squamous cell carcinoma 31.4 TP53 SYP NUTM1 NKX2-1 NAPSA KRT7
2 transitional cell carcinoma 30.2 TP53 KRT7 EGFR CDH1
3 adenoid squamous cell carcinoma 30.1 TP53 KRT7 KRT5 CEACAM5 CDH1
4 keratoacanthoma 29.9 TP53 PIK3CA EGFR CDH1
5 breast ductal carcinoma 29.9 TP53 SYP KRT7 KRT5 EGFR CDH1
6 cervical squamous cell carcinoma 29.8 TP53 PIK3CA EGFR CEACAM5 CDKN2A CDH1
7 skin squamous cell carcinoma 29.7 TP53 KRT5 HRAS EGFR CDKN2A CDH1
8 vulva squamous cell carcinoma 29.7 TP53 PIK3CA HRAS EGFR CDKN2A
9 ductal carcinoma in situ 29.7 TP53 PIK3CA KRT5 EGFR CDKN2A CDH1
10 nasopharyngeal carcinoma 29.5 TP53 PSMB9 PIK3CA EGFR CDKN2A CDH1
11 gallbladder adenocarcinoma 29.3 TP53 SYP KRT7 HRAS CEACAM5 CDX2
12 squamous cell carcinoma 29.2 TP53 PIK3CA NKX2-1 KRT7 HRAS EGFR
13 head and neck cancer 29.2 TP53 PIK3CA HRAS EGFR CDKN2A CDH1
14 squamous cell carcinoma, head and neck 29.1 TP53 PIK3CA HRAS EGFR CDKN2A CDH1
15 vulva cancer 29.0 TP53 PIK3CA KRT7 HRAS EGFR CEACAM5
16 adenoma 28.6 TP53 SYP PIK3CA KRT7 HRAS CDX2
17 cervix carcinoma 28.4 TP53 TAAR6 PIK3CA KRT7 HRAS EGFR
18 gallbladder cancer 28.3 TP53 PIK3CA KRT7 HRAS EGFR CEACAM5
19 vulvar keratinizing squamous cell carcinoma 11.6
20 cervical keratinizing squamous cell carcinoma 11.6
21 cervical non-keratinizing squamous cell carcinoma 11.6
22 vulvar non-keratinizing squamous cell carcinoma 11.5
23 penile urethral cancer 10.4 KRT5 CDKN2A
24 cervical basaloid squamous cell carcinoma 10.4 KRT7 CDKN2A
25 adenosquamous breast carcinoma 10.4 TP53 KRT5
26 lymphoepithelioma-like thymic carcinoma 10.4 NUTM1 KRT5
27 basaloid lung carcinoma 10.4 TP53 KRT5
28 laryngeal adenoid cystic carcinoma 10.4 KRT7 KRT5
29 b-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) 10.4 TP53 CDKN2A
30 microinvasive cervical squamous cell carcinoma 10.4 KRT7 KRT5
31 ceruminoma 10.4 KRT7 KRT5
32 tonsillar pillar cancer 10.4 EGFR CDKN2A
33 subareolar duct papillomatosis 10.4 KRT7 KRT5
34 prostatic urethral cancer 10.4 KRT7 KRT5
35 atrophic vulva 10.4 KRT7 CDKN2A
36 nipple benign neoplasm 10.3 KRT7 KRT5
37 rete testis neoplasm 10.3 KRT7 KRT5
38 adenosquamous gallbladder carcinoma 10.3 KRT7 KRT5
39 rete testis adenocarcinoma 10.3 KRT7 KRT5
40 breast mucoepidermoid carcinoma 10.3 KRT7 KRT5
41 ovarian mucinous cystadenofibroma 10.3 SYP KRT7
42 mucinous cystadenofibroma 10.3 SYP KRT7
43 ovarian mucinous adenofibroma 10.3 SYP KRT7
44 cloacogenic carcinoma 10.3 SYP KRT5
45 ceruminous adenocarcinoma 10.3 KRT7 KRT5
46 lung meningioma 10.3 SYP NKX2-1
47 posterior pituitary gland neoplasm 10.3 SMARCB1 NKX2-1
48 gastric squamous cell carcinoma 10.3 KRT7 KRT5
49 vagina leiomyoma 10.3 CEACAM5 CDKN2A
50 bile duct mucinous adenocarcinoma 10.3 TP53 SYP

Graphical network of the top 20 diseases related to Keratinizing Squamous Cell Carcinoma:



Diseases related to Keratinizing Squamous Cell Carcinoma

Symptoms & Phenotypes for Keratinizing Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

25 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 10.07 EGFR HRAS PIK3CA
2 Decreased viability GR00055-A-2 10.07 EGFR HRAS PIK3CA
3 Decreased viability GR00221-A-1 10.07 CDH1 CDKN2A EGFR HRAS PIK3CA SMARCB1
4 Decreased viability GR00221-A-2 10.07 HRAS PIK3CA SMARCB1
5 Decreased viability GR00221-A-3 10.07 CDKN2A HRAS SMARCB1
6 Decreased viability GR00221-A-4 10.07 CDKN2A EGFR PIK3CA
7 Decreased viability GR00249-S 10.07 SMARCB1
8 Decreased viability GR00301-A 10.07 CDH1
9 Decreased viability GR00381-A-1 10.07 SMARCB1
10 Decreased viability GR00402-S-2 10.07 CDH1 PIK3CA
11 Increased transferrin (TF) endocytosis (mild increase), increased transferrin (TF) endosome elongation GR00363-A 8.32 HRAS

MGI Mouse Phenotypes related to Keratinizing Squamous Cell Carcinoma:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 CDH1 CDKN2A CDX2 CEACAM5 EGFR HRAS
2 neoplasm MP:0002006 10.24 CDH1 CDKN2A CDX2 CEACAM5 EGFR HRAS
3 growth/size/body region MP:0005378 10.22 ARL2BP CDH1 CDKN2A CDX2 CEACAM5 EGFR
4 endocrine/exocrine gland MP:0005379 10.07 CDH1 CDKN2A CDX2 CEACAM5 EGFR HRAS
5 muscle MP:0005369 10.06 CDKN2A CEACAM5 EGFR HRAS PIK3CA PSMB9
6 digestive/alimentary MP:0005381 10.06 CDH1 CDKN2A CDX2 CEACAM5 EGFR HRAS
7 cellular MP:0005384 10.03 ARL2BP CDH1 CDKN2A CDX2 CEACAM5 EGFR
8 no phenotypic analysis MP:0003012 10.02 CDH1 CDKN2A EGFR HRAS NKX2-1 PIK3CA
9 cardiovascular system MP:0005385 9.85 CDH1 CDKN2A CDX2 CEACAM5 EGFR HRAS
10 reproductive system MP:0005389 9.65 ARL2BP CDH1 CDKN2A CDX2 EGFR NKX2-1
11 skeleton MP:0005390 9.28 ARL2BP CDKN2A CDX2 EGFR HRAS NKX2-1

Drugs & Therapeutics for Keratinizing Squamous Cell Carcinoma

Drugs for Keratinizing Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amifostine Approved, Investigational Phase 3 20537-88-6 2141
2
Fluorouracil Approved Phase 3 51-21-8 3385
3
Cisplatin Approved Phase 3 15663-27-1 2767 5702198 441203
4
Carboplatin Approved Phase 3 41575-94-4 10339178 38904
5
Nivolumab Approved Phase 3 946414-94-4
6
Gemcitabine Approved Phase 3 95058-81-4, 122111-03-9 60750
7 Radiation-Protective Agents Phase 3
8 Protective Agents Phase 3
9 Antineoplastic Agents, Immunological Phase 3
10 Immunologic Factors Phase 3
11 Antimetabolites Phase 3
12 Immunosuppressive Agents Phase 3
13 Antiviral Agents Phase 3
14 Anti-Infective Agents Phase 3
15 Immune Checkpoint Inhibitors Phase 3
16
Cetuximab Approved Phase 2 205923-56-4
17
Bevacizumab Approved, Investigational Phase 2 216974-75-3 135329020
18
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030
19
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
20
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
21
Cediranib Investigational Phase 2 288383-20-0 9933475
22
Maleic acid Experimental, Investigational Phase 2 110-16-7, 110-17-8 444266 444972
23 Immunoglobulins, Intravenous Phase 2
24 Immunoglobulins Phase 2
25 Antibodies, Monoclonal Phase 2
26 Antibodies Phase 2
27 Immunoglobulin G Phase 2
28 Angiogenesis Inhibitors Phase 2
29 Endothelial Growth Factors Phase 2
30 Mitogens Phase 2
31 Protein Kinase Inhibitors Phase 2
32 Anti-Bacterial Agents Phase 2
33 Antifungal Agents Phase 2
34 Antibiotics, Antitubercular Phase 2
35
Lenalidomide Approved Phase 1 191732-72-6 216326
36
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
37
Azacitidine Approved, Investigational Phase 1 320-67-2 9444
38 Histone Deacetylase Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Childhood Nasopharyngeal Carcinoma With Neoadjuvant Chemotherapy and Concomitant Chemoradiotherapy: A Groupwide Phase III Study Completed NCT00274937 Phase 3 Amifostine;Cisplatin;Fluorouracil
2 An Open-Label, Phase III Study of Platinum-Gemcitabine With or Without Nivolumab in the First-Line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma Active, not recruiting NCT04458909 Phase 3 Carboplatin;Cisplatin;Gemcitabine
3 A Randomized, Phase II Study of Ficlatuzumab With or Without Cetuximab in Patients With Cetuximab-Resistant, Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma Completed NCT03422536 Phase 2 Ficlatuzumab
4 A Phase II Study of Concurrent Chemoradiotherapy Using Three-Dimensional Conformal Radiotherapy (3D-CRT) or Intensity-Modulated Radiation Therapy (IMRT) + Bevacizumab (BV) for Locally or Regionally Advanced Nasopharyngeal Cancer Completed NCT00408694 Phase 2 Cisplatin;Fluorouracil
5 Phase II Clinical Trial of AZD2171 Monotherapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Patients Completed NCT00458978 Phase 2 Cediranib Maleate
6 A T1 Translational Multicenter Randomized Phase II Study of Temsirolimus Versus Cetuximab Plus Temsirolimus in Patients With Recurrent / Metastatic Head and Neck Cancer, Who Failed Prior EGFR Based Therapy Completed NCT01256385 Phase 2 Temsirolimus
7 Enhancement of Cetuximab-Induced Antibody-Dependent Cellular Cytotoxicity (ADCC) With Lenalidomide in Advanced Solid Tumors: A Phase I/IB Study Completed NCT01254617 Phase 1 Lenalidomide
8 A Phase I Trial of 5Azacitidine and Suberoylanilide Hydroxamic Acid in Patients With Metastatic or Locally Recurrent Nasopharyngeal Carcinoma and Nasal NK-T Cell Lymphoma Active, not recruiting NCT00336063 Phase 1 Azacitidine;Vorinostat
9 Phase I Dose Escalation Study of Stereotactic Body Radiotherapy for Carcinoma of the Head and Neck in High Risk Patients Who Are Ineligible/Refuse Standard of Care Therapy Terminated NCT02388932

Search NIH Clinical Center for Keratinizing Squamous Cell Carcinoma

Genetic Tests for Keratinizing Squamous Cell Carcinoma

Anatomical Context for Keratinizing Squamous Cell Carcinoma

Organs/tissues related to Keratinizing Squamous Cell Carcinoma:

MalaCards : Cervix, Lymph Node, Endothelial, Lung, Thymus, Trachea, Skin

Publications for Keratinizing Squamous Cell Carcinoma

Articles related to Keratinizing Squamous Cell Carcinoma:

(show top 50) (show all 277)
# Title Authors PMID Year
1
Survival comparison of different histological subtypes of oropharyngeal squamous cell carcinoma: A propensity-matched score analysis based on SEER database. 62
36317416 2022
2
Condyloma acuminatum of the urinary tract demonstrates atypical squamous cells in urine cytology. 62
36244465 2022
3
Solitary rib metastasis from primary nasopharyngeal carcinoma: A rare clinical presentation. 62
36280995 2022
4
Cuneiform (cuniculatum) variant of oral squamous cell carcinoma revisited: Presentation of two cases and literature review of a rare entity. 62
35064717 2022
5
High-risk HPV Does not Appear to be an Important Risk Factor for Sinonasal Carcinomas in Turkish Population: A Tertiary Center Experience. 62
35404169 2022
6
Retrospective analysis of clinical features and prognosis of nasopharyngeal carcinoma in children and adolescents. 62
36186630 2022
7
Re-irradiation with Moderate Hypo-fractionation Using Intensity Modulated Photon or Proton Radiation Therapy in Locally Recurrent Squamous Cell Carcinoma of Nasopharynx. 62
33781049 2022
8
Detection of a second primary cancer in a 18F-fluorocholine PET/CT - multicentre retrospective analysis on a group of 1345 prostate cancer patients. 62
35137934 2022
9
A Novel Prognostic Risk Model for Cervical Cancer Based on Immune Checkpoint HLA-G-Driven Differentially Expressed Genes. 62
35924232 2022
10
Underdiagnosis of early cervical cancer with an invisible cervical transformation zone in an elderly patient: A case report. 62
34671469 2021
11
Oropharyngeal Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN): A Case Report and Literature Review. 62
33709305 2021
12
A Poorly Differentiated Non-keratinizing Sinonasal Squamous Cell Carcinoma with a Novel ETV6-TNFRSF8 Fusion Gene. 62
33394379 2021
13
Thymic cancer: A not-so-indolent cause of pericardial effusion. 62
34659744 2021
14
Value of 18F-FDG PET/CT for Assessment of Advanced Lacrimal Sac Non-Keratinizing Squamous Cell Carcinoma Successfully Treated with Concurrent Chemoradiotherapy. 62
34829312 2021
15
Notably small bronchial carcinoid accompanied by peripheral squamous cell carcinoma. 62
34589229 2021
16
Carcinomatous-like mastitis due to axillary lymphadenopathy in a case of nasopharyngeal carcinoma: A case report. 62
34373712 2021
17
EGFR Protein Expression Relates with Tumor Histology, Methylation Status of EGFR and HPV16 E6 Viral Load in Oropharyngeal Carcinoma. 62
33428063 2021
18
Malignant pleural neoplasm with both differentiation of epithelioid mesothelioma and squamous-cell carcinoma, a rare phenomena. 62
33347735 2021
19
Descriptive epidemiology of nasopharyngeal carcinoma at Tikur Anbessa Hospital, Ethiopia. 62
33980204 2021
20
[Extracranial/intracranial vascular bypass to control carotid artery blowout in postirradiated nasopharyngeal carcinoma patients]. 62
34304473 2021
21
Rectal Squamous Cell Cancer. 62
34159035 2021
22
A case of human papillomavirus infection and vulvar cancer in a young patient - "hit and run" theory. 62
33869714 2021
23
Metastatic Patterns and Prognosis of de novo Metastatic Nasopharyngeal Carcinoma in the United States. 62
32833262 2021
24
Clinical and Pathologic Presentation of Primary Ocular Surface Tumors among Zambians. 62
33869164 2021
25
Tonsillar p16-Positive Follicular Dendritic Cell Sarcoma Mimicking HPV-Related Oropharyngeal Squamous Cell Carcinoma: A Case Report and Review of Reported Cases. 62
32189159 2021
26
A Rare Case of Invasive Keratinizing Squamous Cell Carcinoma of the Foot. 62
34113181 2021
27
Oropharyngeal carcinoma: A single institution study of 338 primaries with special reference to high-risk human papillomavirus-mediated carcinoma with aggressive behavior. 62
33113454 2020
28
Tumor Embolism Through Right-to-Left Shunt Due to Venous Invasion of Esophageal Carcinoma. 62
33010722 2020
29
Image-guided interstitial brachytherapy boost for keratinizing squamous cell carcinoma of inferior wall of the nasopharynx. 62
33299579 2020
30
Nonkeratinizing Nasopharyngeal Carcinoma, Undifferentiated Type With Trisomy 2: A Case Report and Short Review of Cytogenetic and Molecular Literature. 62
32755442 2020
31
Telangiectatic Squamous Cell Carcinoma of Uterine Cervix: A Previously Undescribed Variant of Squamous Cell Carcinoma. 62
31651557 2020
32
[Teicoplanin-induced hypersensitivity syndrome in a diabetic foot patient with malignant ulcer]. 62
32829619 2020
33
EGFR and αvβ6 as Promising Targets for Molecular Imaging of Cutaneous and Mucosal Squamous Cell Carcinoma of the Head and Neck Region. 62
32516897 2020
34
SMARCB1 (INI-1)-Deficient Adenocarcinoma of the Sinonasal Tract: A Potentially Under-Recognized form of Sinonasal Adenocarcinoma with Occasional Yolk Sac Tumor-Like Features. 62
31468350 2020
35
Upper Gastrointestinal Bleeding Due to a Duodenal Metastasis from Primary Testicular Squamous Cell Carcinoma. 62
32392185 2020
36
Survival comparison of Three histological subtypes of lung squamous cell carcinoma: A population-based propensity score matching analysis. 62
32062199 2020
37
Histological subtype remains a prognostic factor for survival in nasopharyngeal carcinoma patients. 62
31188486 2020
38
Cervical Cancer Care Continuum in South India: Evidence from a Community-based Screening Program. 62
32175707 2020
39
Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study. 62
32774641 2020
40
Comparative study on the mutational profile of adenocarcinoma and squamous cell carcinoma predominant histologic subtypes in Chinese non-small cell lung cancer patients. 62
31692283 2020
41
Comprehensive Molecular Characterizations of Chinese Patients With Different Subtypes of Lung Squamous Cell Carcinoma. 62
33363036 2020
42
The effect of histological subtypes on survival outcome in nasopharyngeal carcinoma after extensive follow up. 62
32042784 2019
43
Phase I trial of belinostat in combination with 13-cis-retinoic acid in advanced solid tumor malignancies: a California Cancer Consortium NCI/CTEP sponsored trial. 62
31522242 2019
44
Lymph Node Status and Outcomes for Nasopharyngeal Carcinoma According to Histological Subtypes: A SEER Population-Based Retrospective Analysis. 62
31559602 2019
45
Adenoid Basal Carcinoma of the Uterine Cervix in Association with Keratinizing Squamous Cell Carcinoma: a Rare Diagnosis. 62
31496589 2019
46
Nasopharyngeal undifferentiated carcinoma with sarcomatoid features: Pitfalls in the immunohistochemistry. 62
31427557 2019
47
Molecular profile of tongue cancer in an 18-year-old female patient with no recognizable risk factor. 62
31236464 2019
48
Radiation therapy for vaginal cancer in complete uterine prolapse with intrauterine adhesion: a case report. 62
31122220 2019
49
Lung squamous cell carcinoma: A postoperative recurrence analysis of keratinizing and nonkeratinizing subtypes. 62
30389303 2019
50
Rapid Progression of Intracranial Dural Metastases in a Patient with Carcinoma of Unknown Primary Site. 62
31572156 2019

Variations for Keratinizing Squamous Cell Carcinoma

Expression for Keratinizing Squamous Cell Carcinoma

Search GEO for disease gene expression data for Keratinizing Squamous Cell Carcinoma.

Pathways for Keratinizing Squamous Cell Carcinoma

Pathways related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.47 TP53 PIK3CA HRAS EGFR CDKN2A CDH1
2 12.41 CDH1 CDKN2A EGFR HRAS PIK3CA TP53
3
Show member pathways
12.33 TP53 PIK3CA HRAS CDH1
4
Show member pathways
12.32 TP53 PIK3CA HRAS EGFR
5
Show member pathways
12.32 TP53 PIK3CA HRAS EGFR CDH1
6
Show member pathways
12.27 TP53 PIK3CA HRAS EGFR
7
Show member pathways
12.09 TP53 PIK3CA HRAS EGFR
8 11.98 TP53 PIK3CA HRAS CDH1
9
Show member pathways
11.94 TP53 PIK3CA HRAS CDKN2A
10 11.83 TP53 HRAS CDKN2A
11 11.8 TP53 PIK3CA HRAS
12
Show member pathways
11.78 PIK3CA HRAS EGFR
13 11.68 HRAS PIK3CA TP53
14
Show member pathways
11.62 TP53 PIK3CA HRAS
15 11.6 PIK3CA HRAS EGFR CDKN2A CDH1
16 11.56 PIK3CA HRAS CDH1
17 11.49 TP53 PIK3CA HRAS
18 11.45 NKX2-1 CDX2 CDH1
19 11.35 CDH1 EGFR HRAS
20 11.22 TP53 PIK3CA HRAS EGFR CDKN2A
21 11.21 TP53 HRAS EGFR
22 11.13 PIK3CA HRAS EGFR CDH1
23 10.84 PIK3CA EGFR CDH1
24 10.62 TP53 HRAS EGFR CDKN2A CDH1
25 10.58 PIK3CA EGFR
26 10.57 TP53 CDH1

GO Terms for Keratinizing Squamous Cell Carcinoma

Cellular components related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 germ cell nucleus GO:0043073 8.92 TP53 SMARCB1

Biological processes related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-templated transcription GO:0045893 9.4 TP53 NKX2-1 EGFR CDX2 CDKN2A CDH1
2 positive regulation of miRNA maturation GO:1903800 8.96 TP53 EGFR

Sources for Keratinizing Squamous Cell Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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