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MCID: KRT003
MIFTS: 36

Keratinizing Squamous Cell Carcinoma

Categories: Cancer diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Keratinizing Squamous Cell Carcinoma

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MalaCards integrated aliases for Keratinizing Squamous Cell Carcinoma:

Name: Keratinizing Squamous Cell Carcinoma 12 15 17
Squamous Cell Carcinoma, Keratinizing 12 74
Keratinizing Epidermoid Carcinoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5521
NCIt 51 C4105
SNOMED-CT 69 18048008
UMLS 74 C0334247
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Summaries for Keratinizing Squamous Cell Carcinoma

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Disease Ontology : 12 A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris.

MalaCards based summary : Keratinizing Squamous Cell Carcinoma, also known as squamous cell carcinoma, keratinizing, is related to basaloid squamous cell carcinoma and cervix carcinoma. An important gene associated with Keratinizing Squamous Cell Carcinoma is KRT5 (Keratin 5), and among its related pathways/superpathways are Bladder cancer and Platinum drug resistance. The drugs Bevacizumab and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include endothelial, t cells and cervix.

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Related Diseases for Keratinizing Squamous Cell Carcinoma

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Diseases related to Keratinizing Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 basaloid squamous cell carcinoma 32.2 CDKN2A TP53
2 cervix carcinoma 30.2 CDKN2A TP53
3 vulvar keratinizing squamous cell carcinoma 12.6
4 cervical keratinizing squamous cell carcinoma 12.5
5 vulvar non-keratinizing squamous cell carcinoma 12.4
6 cervical non-keratinizing squamous cell carcinoma 12.4
7 squamous cell carcinoma 10.6
8 inverted transitional papilloma 10.3 CDKN2A KRT5
9 optic nerve sheath meningioma 10.3 CDKN2A KRT5
10 lymphoepithelioma-like thymic carcinoma 10.3 CDKN2A KRT5
11 anal canal squamous cell carcinoma 10.3 CDKN2A KRT5
12 nasal cavity squamous cell carcinoma 10.3 CDKN2A KRT5
13 pleural cancer 10.3 CDKN2A KRT5
14 anus cancer 10.3 CDKN2A KRT5
15 malignant spiradenoma 10.2 KRT5 TP53
16 breast squamous cell carcinoma 10.2 KRT5 TP53
17 adenosquamous carcinoma 10.2 KRT5 TP53
18 prostate squamous cell carcinoma 10.2 KRT5 TP53
19 pharynx cancer 10.2 CDKN2A TP53
20 bladder squamous cell carcinoma 10.2 CDKN2A TP53
21 spitz nevus 10.2 CDKN2A TP53
22 bladder carcinoma in situ 10.2 CDKN2A TP53
23 vulva squamous cell carcinoma 10.2 CDKN2A TP53
24 breast benign neoplasm 10.2 KRT5 TP53
25 scrotal carcinoma 10.2 CDKN2A TP53
26 thoracic benign neoplasm 10.2 KRT5 TP53
27 eccrine sweat gland neoplasm 10.2 KRT5 TP53
28 thyroid lymphoma 10.2 CDKN2A TP53
29 vulvar disease 10.2 CDKN2A TP53
30 nasal cavity adenocarcinoma 10.2 CDKN2A TP53
31 bartholin's gland disease 10.2 CDKN2A TP53
32 anal squamous cell carcinoma 10.2 CDKN2A TP53
33 megaesophagus 10.2 CDKN2A TP53
34 glycogen-rich clear cell breast carcinoma 10.2 CDKN2A TP53
35 gastric adenosquamous carcinoma 10.2 CDKN2A TP53
36 anogenital venereal wart 10.2 CDKN2A TP53
37 cervix uteri carcinoma in situ 10.2 CDKN2A TP53
38 uterus carcinoma in situ 10.2 CDKN2A TP53
39 oral leukoplakia 10.2 CDKN2A TP53
40 meningeal melanomatosis 10.2 CDKN2A TP53
41 hidradenocarcinoma 10.2 KRT5 TP53
42 suppressor of tumorigenicity 3 10.2 CDKN2A TP53
43 dedifferentiated liposarcoma 10.2 CDKN2A TP53
44 liposarcoma 10.2 CDKN2A TP53
45 endocervical adenocarcinoma 10.2 CDKN2A TP53
46 cervical adenocarcinoma 10.2 CDKN2A TP53
47 penile disease 10.2 CDKN2A TP53
48 cervix small cell carcinoma 10.2 CDKN2A TP53
49 small cell carcinoma 10.2 CDKN2A TP53
50 verrucous carcinoma 10.2 CDKN2A TP53

Graphical network of the top 20 diseases related to Keratinizing Squamous Cell Carcinoma:



Diseases related to Keratinizing Squamous Cell Carcinoma
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Symptoms & Phenotypes for Keratinizing Squamous Cell Carcinoma

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Drugs & Therapeutics for Keratinizing Squamous Cell Carcinoma

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Drugs for Keratinizing Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3
2
Fluorouracil Approved Phase 2 51-21-8 3385
3
Cisplatin Approved Phase 2 15663-27-1 441203 84093 2767
4
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
5
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
6
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
7
Cetuximab Approved Phase 2,Phase 1 205923-56-4 56842117 2333
8
SB-649868 Experimental, Investigational Phase 2 110-16-7, 110-17-8 444972
9
Cediranib Investigational Phase 2 288383-20-0 9933475
10 Immunoglobulins Phase 2,Phase 1
11 Antimetabolites Phase 2,Phase 1
12 Angiogenesis Inhibitors Phase 2,Phase 1
13 Antimetabolites, Antineoplastic Phase 2,Phase 1
14 Immunoglobulin G Phase 2
15 Immunologic Factors Phase 2,Phase 1
16 Angiogenesis Modulating Agents Phase 2,Phase 1
17 Antibodies Phase 2,Phase 1
18 Antibodies, Monoclonal Phase 2,Phase 1
19 Immunosuppressive Agents Phase 2
20 Mitogens Phase 2
21 Endothelial Growth Factors Phase 2
22 Antineoplastic Agents, Immunological Phase 2,Phase 1
23 Antifungal Agents Phase 2
24 Anti-Infective Agents Phase 2
25 Anti-Bacterial Agents Phase 2
26 Antibiotics, Antitubercular Phase 2
27 Protein Kinase Inhibitors Phase 2
28
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
29
Azacitidine Approved, Investigational Phase 1 320-67-2 9444
30
Lenalidomide Approved Phase 1 191732-72-6 216326
31 Histone Deacetylase Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bevacizumab, Cisplatin, Radiation Therapy, and Fluorouracil in Treating Patients With Stage IIB, Stage III, Stage IVA, or Stage IVB Nasopharyngeal Cancer Completed NCT00408694 Phase 2 Cisplatin;Fluorouracil
2 Temsirolimus With or Without Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Cancer Who Did Not Respond to Previous Therapy Completed NCT01256385 Phase 2 Temsirolimus
3 Cediranib Maleate in Treating Patients With Recurrent or Newly Diagnosed Metastatic Head and Neck Cancer Completed NCT00458978 Phase 2 Cediranib Maleate
4 Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma Recruiting NCT03422536 Phase 2 Ficlatuzumab
5 Vorinostat and Azacitidine in Treating Patients With Locally Recurrent or Metastatic Nasopharyngeal Cancer or Nasal Natural Killer T-Cell Lymphoma Active, not recruiting NCT00336063 Phase 1 Azacitidine;Vorinostat
6 Lenalidomide and Cetuximab in Treating Patients With Advanced Colorectal Cancer or Head and Neck Cancer Active, not recruiting NCT01254617 Phase 1 Lenalidomide
7 Stereotactic Body Radiation Therapy in Treating Patients With High Risk Locally Advanced Head and Neck Cancer Terminated NCT02388932 Not Applicable

Search NIH Clinical Center for Keratinizing Squamous Cell Carcinoma

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Genetic Tests for Keratinizing Squamous Cell Carcinoma

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Anatomical Context for Keratinizing Squamous Cell Carcinoma

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MalaCards organs/tissues related to Keratinizing Squamous Cell Carcinoma:

42
Endothelial, T Cells, Cervix, Skin, Kidney, Pancreas
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Publications for Keratinizing Squamous Cell Carcinoma

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Articles related to Keratinizing Squamous Cell Carcinoma:

(show all 18)
# Title Authors Year
1
Human papillomavirus (HPV) and Epstein-Barr virus (EBV) in keratinizing versus non- keratinizing squamous cell carcinoma of the oropharynx. ( 30455727 )
2018
2
Endosonography and Confocal Endomicroscopy of Primary Keratinizing Squamous Cell Carcinoma of the Pancreas. ( 28184374 )
2017
3
Invasive keratinizing squamous cell carcinoma of the left external auricular canal and the middle ear - case report. ( 29556651 )
2017
4
Carcinoma ex-pleomorphic adenoma of the parotid gland consisting of high-grade salivary duct carcinoma and keratinizing squamous cell carcinoma. ( 25782724 )
2015
5
Sinonasal non-keratinizing squamous cell carcinoma with nasal skin extension as the initial presentation. ( 22775560 )
2012
6
Mammary invasive ductal adenocarcinoma and vulvar invasive keratinizing squamous cell carcinoma in a woman with disseminated discoid lupus erythematosus (DDLE) - a case review. ( 21876498 )
2011
7
Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: report of two cases. ( 21119270 )
2010
8
Psammoma bodies in cervical smear in association with keratinizing squamous cell carcinoma of cervix: a case report. ( 19217043 )
2009
9
Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology. ( 17060483 )
2007
10
Keratinizing squamous cell carcinoma of the cervix in a sexually inexperienced woman: a case report. ( 17039710 )
2006
11
Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus. ( 15688099 )
2005
12
Vulvar keratinizing squamous cell carcinoma in a 26-year-old woman. ( 11175649 )
2001
13
Case report: primary cystic keratinizing squamous cell carcinoma of the liver in a patient with treated nasopharyngeal carcinoma. ( 9142640 )
1997
14
Primary keratinizing squamous cell carcinoma: an exceptional tumor of the gallbladder. ( 19864815 )
1997
15
Basaloid carcinoma and keratinizing squamous cell carcinoma of the vulva: a case of two primary carcinomas. ( 8572644 )
1995
16
Neoplastic cell spreading in rodent transplantable tumor models. II. Santamaria tumor (syngeneic keratinizing squamous cell carcinoma). ( 2378738 )
1990
17
Glandular cell properties of cell line (HKUS) derived from small cell non-keratinizing squamous cell carcinoma of the uterine cervix. ( 2838556 )
1988
18
An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen. ( 2429552 )
1986
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Variations for Keratinizing Squamous Cell Carcinoma

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Expression for Keratinizing Squamous Cell Carcinoma

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Search GEO for disease gene expression data for Keratinizing Squamous Cell Carcinoma.
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Pathways for Keratinizing Squamous Cell Carcinoma

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Pathways related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Bladder cancer 38 1
11.3 CDKN2A TP53
2
Platinum drug resistance 38
11.27 CDKN2A TP53
3
Regulation of TP53 Expression and Degradation 67
Show member pathways
 11.23 CDKN2A TP53
4
HIF1Alpha Pathway 65
11.05 CDKN2A TP53
5
Photodynamic therapy-induced AP-1 survival signaling. 1
10.96 CDKN2A TP53
6
Oncogene Induced Senescence 67
10.66 CDKN2A TP53
7
Inhibition of Ribosome Biogenesis by p14(ARF) 65
10.3 CDKN2A TP53
8
TP53 Network 1
Show member pathways
 9.97 CDKN2A TP53
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GO Terms for Keratinizing Squamous Cell Carcinoma

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Biological processes related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.16 CDKN2A TP53
2 positive regulation of apoptotic process GO:0043065 9.13 AKAP13 CDKN2A TP53
3 replicative senescence GO:0090399 8.62 CDKN2A TP53

Molecular functions related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 CDKN2A TP53
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Sources for Keratinizing Squamous Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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