Keratinizing Squamous Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Keratinizing Squamous Cell Carcinoma

MalaCards integrated aliases for Keratinizing Squamous Cell Carcinoma:

Name: Keratinizing Squamous Cell Carcinoma ¹² ¹⁵

Squamous Cell Carcinoma, Keratinizing ¹² ⁷³

Keratinizing Epidermoid Carcinoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5521

NCIt ⁵⁰ C4105

SNOMED-CT ⁶⁸ 18048008

UMLS ⁷³ C0334247

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Summaries for Keratinizing Squamous Cell Carcinoma

Disease Ontology : ¹² A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris.

MalaCards based summary : Keratinizing Squamous Cell Carcinoma, also known as squamous cell carcinoma, keratinizing, is related to basaloid squamous cell carcinoma and cervix carcinoma. An important gene associated with Keratinizing Squamous Cell Carcinoma is KRT5 (Keratin 5), and among its related pathways/superpathways are Bladder cancer and Platinum drug resistance. The drugs Cisplatin and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, cervix and pancreas.

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Related Diseases for Keratinizing Squamous Cell Carcinoma

Diseases related to Keratinizing Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)

#	Related Disease	Score	Top Affiliating Genes
1	basaloid squamous cell carcinoma	31.9	CDKN2A TP53
2	cervix carcinoma	29.9	CDKN2A TP53
3	vulvar keratinizing squamous cell carcinoma	12.5
4	cervical keratinizing squamous cell carcinoma	12.5
5	vulvar non-keratinizing squamous cell carcinoma	12.4
6	cervical non-keratinizing squamous cell carcinoma	12.4
7	squamous cell carcinoma	10.6
8	inverted transitional papilloma	10.2	CDKN2A KRT5
9	optic nerve sheath meningioma	10.2	CDKN2A KRT5
10	lymphoepithelioma-like thymic carcinoma	10.2	CDKN2A KRT5
11	anal canal squamous cell carcinoma	10.2	CDKN2A KRT5
12	nasal cavity squamous cell carcinoma	10.2	CDKN2A KRT5
13	pleural cancer	10.2	CDKN2A KRT5
14	anus cancer	10.2	CDKN2A KRT5
15	nasopharyngeal carcinoma	10.1
16	malignant spiradenoma	10.0	KRT5 TP53
17	breast squamous cell carcinoma	10.0	KRT5 TP53
18	adenosquamous carcinoma	10.0	KRT5 TP53
19	prostate squamous cell carcinoma	10.0	KRT5 TP53
20	pharynx cancer	10.0	CDKN2A TP53
21	bladder squamous cell carcinoma	10.0	CDKN2A TP53
22	spitz nevus	10.0	CDKN2A TP53
23	breast benign neoplasm	10.0	KRT5 TP53
24	bladder carcinoma in situ	10.0	CDKN2A TP53
25	thoracic benign neoplasm	10.0	KRT5 TP53
26	vulva squamous cell carcinoma	10.0	CDKN2A TP53
27	scrotal carcinoma	10.0	CDKN2A TP53
28	eccrine sweat gland neoplasm	10.0	KRT5 TP53
29	vulvar disease	10.0	CDKN2A TP53
30	nasal cavity adenocarcinoma	10.0	CDKN2A TP53
31	bartholin's gland disease	10.0	CDKN2A TP53
32	anal squamous cell carcinoma	10.0	CDKN2A TP53
33	megaesophagus	10.0	CDKN2A TP53
34	glycogen-rich clear cell breast carcinoma	10.0	CDKN2A TP53
35	gastric adenosquamous carcinoma	10.0	CDKN2A TP53
36	anogenital venereal wart	10.0	CDKN2A TP53
37	cervix uteri carcinoma in situ	10.0	CDKN2A TP53
38	uterus carcinoma in situ	10.0	CDKN2A TP53
39	oral leukoplakia	10.0	CDKN2A TP53
40	meningeal melanomatosis	10.0	CDKN2A TP53
41	suppressor of tumorigenicity 3	10.0	CDKN2A TP53
42	hidradenocarcinoma	10.0	KRT5 TP53
43	dedifferentiated liposarcoma	10.0	CDKN2A TP53
44	liposarcoma	10.0	CDKN2A TP53
45	endocervical adenocarcinoma	10.0	CDKN2A TP53
46	cervical adenocarcinoma	10.0	CDKN2A TP53
47	penile disease	10.0	CDKN2A TP53
48	cervix small cell carcinoma	10.0	CDKN2A TP53
49	small cell carcinoma	10.0	CDKN2A TP53
50	verrucous carcinoma	10.0	CDKN2A TP53

Graphical network of the top 20 diseases related to Keratinizing Squamous Cell Carcinoma:

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Symptoms & Phenotypes for Keratinizing Squamous Cell Carcinoma

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Drugs & Therapeutics for Keratinizing Squamous Cell Carcinoma

Drugs for Keratinizing Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Cisplatin

Approved

Phase 2

15663-27-1

2767 441203 84093

2

Bevacizumab

Approved, Investigational

Phase 2

216974-75-3

3

Fluorouracil

Approved

Phase 2

51-21-8

3385

4

Sirolimus

Approved, Investigational

Phase 2

53123-88-9

46835353 6436030 5284616

5

Cetuximab

Approved

Phase 2,Phase 1

205923-56-4

56842117 2333

6

Everolimus

Approved

Phase 2

159351-69-6

6442177

7

Miconazole

Approved, Investigational, Vet_approved

Phase 2

22916-47-8

4189

8

Cediranib

Investigational

Phase 2

288383-20-0

9933475

9

Maleic acid

Experimental

Phase 2

110-16-7

444266

10

Immunoglobulin G

Phase 2

11

Immunosuppressive Agents

Phase 2,Phase 1

12

Antibodies, Monoclonal

Phase 2,Phase 1

13

Angiogenesis Modulating Agents

Phase 2,Phase 1

14

Antibodies

Phase 2,Phase 1

15

Immunologic Factors

Phase 2,Phase 1

16

Angiogenesis Inhibitors

Phase 2,Phase 1

17

Mitogens

Phase 2

18

Antimetabolites

Phase 2,Phase 1

19

Endothelial Growth Factors

Phase 2

20

Antimetabolites, Antineoplastic

Phase 2,Phase 1

21

Immunoglobulins

Phase 2,Phase 1

22

Anti-Bacterial Agents

Phase 2,Phase 1

23

Antifungal Agents

Phase 2

24

Antibiotics, Antitubercular

Phase 2

25

Anti-Infective Agents

Phase 2,Phase 1

26

Protein Kinase Inhibitors

Phase 2

27

Vorinostat

Approved, Investigational

Phase 1

149647-78-9

5311

28

Azacitidine

Approved, Investigational

Phase 1

320-67-2

9444

29

Lenalidomide

Approved

Phase 1

191732-72-6

216326

30

Histone Deacetylase Inhibitors

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Bevacizumab, Cisplatin, Radiation Therapy, and Fluorouracil in Treating Patients With Stage IIB, Stage III, Stage IVA, or Stage IVB Nasopharyngeal Cancer	Completed	NCT00408694	Phase 2	Cisplatin;Fluorouracil
2	Temsirolimus With or Without Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Cancer Who Did Not Respond to Previous Therapy	Completed	NCT01256385	Phase 2	Temsirolimus
3	Cediranib Maleate in Treating Patients With Recurrent or Newly Diagnosed Metastatic Head and Neck Cancer	Completed	NCT00458978	Phase 2	Cediranib Maleate
4	Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma	Recruiting	NCT03422536	Phase 2	Ficlatuzumab
5	Vorinostat and Azacitidine in Treating Patients With Locally Recurrent or Metastatic Nasopharyngeal Cancer or Nasal Natural Killer T-Cell Lymphoma	Active, not recruiting	NCT00336063	Phase 1	Azacitidine;Vorinostat
6	Lenalidomide and Cetuximab in Treating Patients With Advanced Colorectal Cancer or Head and Neck Cancer	Active, not recruiting	NCT01254617	Phase 1	Lenalidomide
7	Stereotactic Body Radiation Therapy in Treating Patients With High Risk Locally Advanced Head and Neck Cancer	Terminated	NCT02388932	Not Applicable

Search NIH Clinical Center for Keratinizing Squamous Cell Carcinoma

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Genetic Tests for Keratinizing Squamous Cell Carcinoma

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Anatomical Context for Keratinizing Squamous Cell Carcinoma

MalaCards organs/tissues related to Keratinizing Squamous Cell Carcinoma:

⁴¹

Skin, Cervix, Pancreas, Lung, Endothelial, Thymus, Uterus

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Publications for Keratinizing Squamous Cell Carcinoma

Articles related to Keratinizing Squamous Cell Carcinoma:

(show all 18)

#	Title	Authors	Year
1	Human papillomavirus (HPV) and Epstein-Barr virus (EBV) in keratinizing versus non- keratinizing squamous cell carcinoma of the oropharynx. ( 30455727 )	Broccolo F...Toniolo A	2018
2	Endosonography and Confocal Endomicroscopy of Primary Keratinizing Squamous Cell Carcinoma of the Pancreas. ( 28184374 )	Modi R.M....Krishna S.G.	2017
3	Invasive keratinizing squamous cell carcinoma of the left external auricular canal and the middle ear - case report. ( 29556651 )		2017
4	Carcinoma ex-pleomorphic adenoma of the parotid gland consisting of high-grade salivary duct carcinoma and keratinizing squamous cell carcinoma. ( 25782724 )	Magaki SD...Lai CK	2015
5	Sinonasal non-keratinizing squamous cell carcinoma with nasal skin extension as the initial presentation. ( 22775560 )	Guo R....Crowson A.N.	2012
6	Mammary invasive ductal adenocarcinoma and vulvar invasive keratinizing squamous cell carcinoma in a woman with disseminated discoid lupus erythematosus (DDLE) - a case review. ( 21876498 )		2011
7	Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: report of two cases. ( 21119270 )		2010
8	Psammoma bodies in cervical smear in association with keratinizing squamous cell carcinoma of cervix: a case report. ( 19217043 )		2009
9	Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology. ( 17060483 )	Ou S.H....Anton-Culver H.	2007
10	Keratinizing squamous cell carcinoma of the cervix in a sexually inexperienced woman: a case report. ( 17039710 )		2006
11	Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus. ( 15688099 )		2005
12	Vulvar keratinizing squamous cell carcinoma in a 26-year-old woman. ( 11175649 )	Echeverri C....Valente P.T.	2001
13	Case report: primary cystic keratinizing squamous cell carcinoma of the liver in a patient with treated nasopharyngeal carcinoma. ( 9142640 )	Chou Y.Y....Hsu H.C.	1997
14	Primary keratinizing squamous cell carcinoma: an exceptional tumor of the gallbladder. ( 19864815 )	Al-Hady S.M....Al-Saed A.	1997
15	Basaloid carcinoma and keratinizing squamous cell carcinoma of the vulva: a case of two primary carcinomas. ( 8572644 )		1995
16	Neoplastic cell spreading in rodent transplantable tumor models. II. Santamaria tumor (syngeneic keratinizing squamous cell carcinoma). ( 2378738 )	Roveta G.	1990
17	Glandular cell properties of cell line (HKUS) derived from small cell non-keratinizing squamous cell carcinoma of the uterine cervix. ( 2838556 )	Ishiwata I....Iizuka R.	1988
18	An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen. ( 2429552 )		1986

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Genes for Keratinizing Squamous Cell Carcinoma

Genes related to Keratinizing Squamous Cell Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KRT5	Keratin 5	Protein Coding	15.21	DISEASES inferred ¹⁵
2	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	14.95	DISEASES inferred ¹⁵
3	CLSTN2	Calsyntenin 2	Protein Coding	14.86	DISEASES inferred ¹⁵
4	GLE1	GLE1, RNA Export Mediator	Protein Coding	14.83	DISEASES inferred ¹⁵
5	ANKK1	Ankyrin Repeat And Kinase Domain Containing 1	Protein Coding	14.68	DISEASES inferred ¹⁵
6	TP53	Tumor Protein P53	Protein Coding	14.66	DISEASES inferred ¹⁵
7	AKAP13	A-Kinase Anchoring Protein 13	Protein Coding	14.31	DISEASES inferred ¹⁵

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Variations for Keratinizing Squamous Cell Carcinoma

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Expression for Keratinizing Squamous Cell Carcinoma

Search GEO for disease gene expression data for Keratinizing Squamous Cell Carcinoma.

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Pathways for Keratinizing Squamous Cell Carcinoma

Pathways related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Bladder cancer ³⁷ ¹	11.3	CDKN2A TP53
2	Platinum drug resistance ³⁷	11.27	CDKN2A TP53
3	Regulation of TP53 Expression and Degradation ⁶⁶ Show member pathways Regulation of TP53 Degradation ⁶⁶ Regulation of TP53 Expression ⁶⁶	11.23	CDKN2A TP53
4	HIF1Alpha Pathway ⁶⁴	11.05	CDKN2A TP53
5	Photodynamic therapy-induced AP-1 survival signaling. ¹	10.96	CDKN2A TP53
6	Oncogene Induced Senescence ⁶⁶	10.66	CDKN2A TP53
7	Inhibition of Ribosome Biogenesis by p14(ARF) ⁶⁴	10.3	CDKN2A TP53
8	TP53 Network ¹ Show member pathways Activation, translocation and oligomerization of BAX ⁶⁶	9.97	CDKN2A TP53

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GO Terms for Keratinizing Squamous Cell Carcinoma

Biological processes related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Ras protein signal transduction	GO:0007265	9.16	CDKN2A TP53
2	positive regulation of apoptotic process	GO:0043065	9.13	AKAP13 CDKN2A TP53
3	replicative senescence	GO:0090399	8.62	CDKN2A TP53

Molecular functions related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	disordered domain specific binding	GO:0097718	8.62	CDKN2A TP53

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Sources for Keratinizing Squamous Cell Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

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¹³ diseasecard

¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia