MCID: KRT003
MIFTS: 36

Keratinizing Squamous Cell Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Keratinizing Squamous Cell Carcinoma

MalaCards integrated aliases for Keratinizing Squamous Cell Carcinoma:

Name: Keratinizing Squamous Cell Carcinoma 12 15
Squamous Cell Carcinoma, Keratinizing 12 73
Keratinizing Epidermoid Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5521
NCIt 50 C4105
SNOMED-CT 68 18048008 189568009
UMLS 73 C0334247

Summaries for Keratinizing Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris.

MalaCards based summary : Keratinizing Squamous Cell Carcinoma, also known as squamous cell carcinoma, keratinizing, is related to basaloid squamous cell carcinoma and cervix carcinoma. An important gene associated with Keratinizing Squamous Cell Carcinoma is KRT5 (Keratin 5), and among its related pathways/superpathways are Bladder cancer and Platinum drug resistance. The drugs Cisplatin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include t cells, endothelial and cervix.

Related Diseases for Keratinizing Squamous Cell Carcinoma

Diseases related to Keratinizing Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 basaloid squamous cell carcinoma 32.1 CDKN2A TP53
2 cervix carcinoma 30.1 CDKN2A TP53
3 vulvar keratinizing squamous cell carcinoma 12.4
4 cervical keratinizing squamous cell carcinoma 12.3
5 vulvar non-keratinizing squamous cell carcinoma 12.3
6 cervical non-keratinizing squamous cell carcinoma 12.3
7 inverted transitional papilloma 10.6 CDKN2A KRT5
8 optic nerve sheath meningioma 10.6 CDKN2A KRT5
9 anal canal squamous cell carcinoma 10.6 CDKN2A KRT5
10 cervical clear cell adenocarcinoma 10.6 CDKN2A KRT5
11 nasal cavity squamous cell carcinoma 10.6 CDKN2A KRT5
12 pleural cancer 10.6 CDKN2A KRT5
13 anus cancer 10.5 CDKN2A KRT5
14 squamous cell carcinoma 10.5
15 malignant spiradenoma 10.4 KRT5 TP53
16 vulvar intraepithelial neoplasia 10.4 KRT5 TP53
17 sarcomatoid squamous cell skin carcinoma 10.4 KRT5 TP53
18 breast squamous cell carcinoma 10.3 KRT5 TP53
19 brain stem astrocytic neoplasm 10.3 CDKN2A TP53
20 epidural neoplasm 10.3 KRT5 TP53
21 spitz nevus 10.3 CDKN2A TP53
22 prostate squamous cell carcinoma 10.3 KRT5 TP53
23 bladder carcinoma in situ 10.3 CDKN2A TP53
24 bartholin's gland benign neoplasm 10.3 CDKN2A TP53
25 vulva squamous cell carcinoma 10.3 CDKN2A TP53
26 mixed cell type cancer 10.3 KRT5 TP53
27 thyroid lymphoma 10.3 CDKN2A TP53
28 nasal cavity adenocarcinoma 10.3 CDKN2A TP53
29 bone squamous cell carcinoma 10.3 CDKN2A TP53
30 scrotal carcinoma 10.3 CDKN2A TP53
31 anal squamous cell carcinoma 10.3 CDKN2A TP53
32 glycogen-rich clear cell breast carcinoma 10.3 CDKN2A TP53
33 gastric adenosquamous carcinoma 10.3 CDKN2A TP53
34 oral leukoplakia 10.3 CDKN2A TP53
35 hidradenocarcinoma 10.3 KRT5 TP53
36 anogenital venereal wart 10.3 CDKN2A TP53
37 megaesophagus 10.3 CDKN2A TP53
38 cervix uteri carcinoma in situ 10.3 CDKN2A TP53
39 meningeal melanomatosis 10.3 CDKN2A TP53
40 dedifferentiated liposarcoma 10.3 CDKN2A TP53
41 suppressor of tumorigenicity 3 10.3 CDKN2A TP53
42 oropharynx cancer 10.3 CDKN2A TP53
43 endocervical adenocarcinoma 10.3 CDKN2A TP53
44 sweat gland cancer 10.3 KRT5 TP53
45 cervix small cell carcinoma 10.3 CDKN2A TP53
46 biliary tract neoplasm 10.3 CDKN2A TP53
47 inverted papilloma 10.2 CDKN2A TP53
48 recessive dystrophic epidermolysis bullosa 10.2 CDKN2A TP53
49 vulva cancer 10.2 CDKN2A TP53
50 squamous cell papilloma 10.2 CDKN2A TP53

Graphical network of the top 20 diseases related to Keratinizing Squamous Cell Carcinoma:



Diseases related to Keratinizing Squamous Cell Carcinoma

Symptoms & Phenotypes for Keratinizing Squamous Cell Carcinoma

Drugs & Therapeutics for Keratinizing Squamous Cell Carcinoma

Drugs for Keratinizing Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
2
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
3
Everolimus Approved Phase 2 159351-69-6 6442177
4
Cetuximab Approved Phase 2,Phase 1 205923-56-4 56842117 2333
5
Fluorouracil Approved Phase 2 51-21-8 3385
6
Bevacizumab Approved, Investigational Phase 2 216974-75-3
7
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
8
Cediranib Investigational Phase 2 288383-20-0 9933475
9
Maleic acid Experimental Phase 2 110-16-7 444266
10 Mitogens Phase 2
11 Angiogenesis Inhibitors Phase 2,Phase 1
12 Angiogenesis Modulating Agents Phase 2,Phase 1
13 Endothelial Growth Factors Phase 2
14 Anti-Bacterial Agents Phase 2,Phase 1
15 Antibiotics, Antitubercular Phase 2
16 Immunoglobulin G Phase 2
17 Antibodies Phase 2,Phase 1
18 Immunoglobulins Phase 2,Phase 1
19 Antibodies, Monoclonal Phase 2,Phase 1
20 Immunosuppressive Agents Phase 2,Phase 1
21 Anti-Infective Agents Phase 2,Phase 1
22 Antifungal Agents Phase 2
23 Protein Kinase Inhibitors Phase 2
24 Antimetabolites Phase 2,Phase 1
25 Antimetabolites, Antineoplastic Phase 2,Phase 1
26
Lenalidomide Approved Phase 1 191732-72-6 216326
27
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
28
Azacitidine Approved, Investigational Phase 1 320-67-2 9444
29 Histone Deacetylase Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bevacizumab, Cisplatin, Radiation Therapy, and Fluorouracil in Treating Patients With Stage IIB, Stage III, Stage IVA, or Stage IVB Nasopharyngeal Cancer Completed NCT00408694 Phase 2 Cisplatin;Fluorouracil
2 Temsirolimus With or Without Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Cancer Who Did Not Respond to Previous Therapy Completed NCT01256385 Phase 2 Temsirolimus
3 Cediranib Maleate in Treating Patients With Recurrent or Newly Diagnosed Metastatic Head and Neck Cancer Completed NCT00458978 Phase 2 Cediranib Maleate
4 Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma Recruiting NCT03422536 Phase 2 Ficlatuzumab
5 Vorinostat and Azacitidine in Treating Patients With Locally Recurrent or Metastatic Nasopharyngeal Cancer or Nasal Natural Killer T-Cell Lymphoma Active, not recruiting NCT00336063 Phase 1 Azacitidine;Vorinostat
6 Lenalidomide and Cetuximab in Treating Patients With Advanced Colorectal Cancer or Head and Neck Cancer Active, not recruiting NCT01254617 Phase 1 Lenalidomide
7 Stereotactic Body Radiation Therapy in Treating Patients With High Risk Locally Advanced Head and Neck Cancer Terminated NCT02388932 Not Applicable

Search NIH Clinical Center for Keratinizing Squamous Cell Carcinoma

Genetic Tests for Keratinizing Squamous Cell Carcinoma

Anatomical Context for Keratinizing Squamous Cell Carcinoma

MalaCards organs/tissues related to Keratinizing Squamous Cell Carcinoma:

41
T Cells, Endothelial, Cervix, Skin, Liver, Pancreas, Kidney

Publications for Keratinizing Squamous Cell Carcinoma

Articles related to Keratinizing Squamous Cell Carcinoma:

(show all 18)
# Title Authors Year
1
Differentiated exophytic vulvar intraepithelial lesions are genetically distinct from keratinizing squamous cell carcinomas and contain mutations in PIK3CA. ( 27834349 )
2017
2
Endosonography and Confocal Endomicroscopy of Primary Keratinizing Squamous Cell Carcinoma of the Pancreas. ( 28184374 )
2017
3
Invasive keratinizing squamous cell carcinoma of the left external auricular canal and the middle ear - case report. ( 29556651 )
2017
4
Carcinoma ex-pleomorphic adenoma of the parotid gland consisting of high-grade salivary duct carcinoma and keratinizing squamous cell carcinoma. ( 25782724 )
2015
5
Sinonasal non-keratinizing squamous cell carcinoma with nasal skin extension as the initial presentation. ( 22775560 )
2012
6
Mammary invasive ductal adenocarcinoma and vulvar invasive keratinizing squamous cell carcinoma in a woman with disseminated discoid lupus erythematosus (DDLE) - a case review. ( 21876498 )
2011
7
Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: report of two cases. ( 21119270 )
2010
8
Psammoma bodies in cervical smear in association with keratinizing squamous cell carcinoma of cervix: a case report. ( 19217043 )
2009
9
Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology. ( 17060483 )
2007
10
Keratinizing squamous cell carcinoma of the cervix in a sexually inexperienced woman: a case report. ( 17039710 )
2006
11
Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus. ( 15688099 )
2005
12
Vulvar keratinizing squamous cell carcinoma in a 26-year-old woman. ( 11175649 )
2001
13
Case report: primary cystic keratinizing squamous cell carcinoma of the liver in a patient with treated nasopharyngeal carcinoma. ( 9142640 )
1997
14
Primary keratinizing squamous cell carcinoma: an exceptional tumor of the gallbladder. ( 19864815 )
1997
15
Basaloid carcinoma and keratinizing squamous cell carcinoma of the vulva: a case of two primary carcinomas. ( 8572644 )
1995
16
Neoplastic cell spreading in rodent transplantable tumor models. II. Santamaria tumor (syngeneic keratinizing squamous cell carcinoma). ( 2378738 )
1990
17
Glandular cell properties of cell line (HKUS) derived from small cell non-keratinizing squamous cell carcinoma of the uterine cervix. ( 2838556 )
1988
18
An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen. ( 2429552 )
1986

Variations for Keratinizing Squamous Cell Carcinoma

Expression for Keratinizing Squamous Cell Carcinoma

Search GEO for disease gene expression data for Keratinizing Squamous Cell Carcinoma.

Pathways for Keratinizing Squamous Cell Carcinoma

GO Terms for Keratinizing Squamous Cell Carcinoma

Biological processes related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.16 CDKN2A TP53
2 positive regulation of apoptotic process GO:0043065 9.13 AKAP13 CDKN2A TP53
3 replicative senescence GO:0090399 8.62 CDKN2A TP53

Molecular functions related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 CDKN2A TP53

Sources for Keratinizing Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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