MCID: KRT003
MIFTS: 37

Keratinizing Squamous Cell Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Keratinizing Squamous Cell Carcinoma

MalaCards integrated aliases for Keratinizing Squamous Cell Carcinoma:

Name: Keratinizing Squamous Cell Carcinoma 12 15 17
Squamous Cell Carcinoma, Keratinizing 12 71
Keratinizing Epidermoid Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5521
NCIt 49 C4105
SNOMED-CT 67 18048008
UMLS 71 C0334247

Summaries for Keratinizing Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris.

MalaCards based summary : Keratinizing Squamous Cell Carcinoma, also known as squamous cell carcinoma, keratinizing, is related to basaloid squamous cell carcinoma and vulva squamous cell carcinoma. An important gene associated with Keratinizing Squamous Cell Carcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. The drugs Fluorouracil and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include cervix, lung and lymph node, and related phenotypes are digestive/alimentary and neoplasm

Related Diseases for Keratinizing Squamous Cell Carcinoma

Diseases related to Keratinizing Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 399)
# Related Disease Score Top Affiliating Genes
1 basaloid squamous cell carcinoma 32.8 TP53 KRT7 EGFR CDKN2A
2 vulva squamous cell carcinoma 30.8 TP53 LINC01191 CDKN2A
3 gallbladder squamous cell carcinoma 30.6 KRT5 CEACAM5
4 schneiderian carcinoma 30.6 NUTM1 MAML2
5 pleomorphic adenoma carcinoma 30.5 TP53 MAML2
6 vulvar intraepithelial neoplasia 30.2 TP53 CDKN2A CDH1
7 pleomorphic adenoma 30.1 TP53 MAML2 KRT7 CDKN2A
8 cervix carcinoma 30.0 TP53 TAAR6 CEACAM5 CDKN2A
9 squamous cell carcinoma 29.8 TP53 KRT7 EGFR CEACAM5 CDKN2A CDH1
10 adenoma 29.7 TP53 KRT7 CDKN2A CDH1
11 cervical squamous cell carcinoma 29.5 TP53 EGFR CDKN2A CDH1
12 vulva cancer 29.5 TP53 LINC01191 KRT7 EGFR CEACAM5 CDKN2A
13 oral squamous cell carcinoma 29.5 TP53 EGFR CDKN2A CDH1
14 adenoid squamous cell carcinoma 29.5 KRT7 KRT5 CEACAM5 CDH1
15 skin squamous cell carcinoma 29.3 TP53 KRT5 EGFR CDKN2A CDH1
16 in situ carcinoma 29.3 TP53 KRT5 EGFR CDKN2A CDH1
17 ductal carcinoma in situ 29.3 TP53 KRT5 EGFR CDKN2A CDH1
18 transitional cell carcinoma 29.2 TP53 KRT7 EGFR CDKN2A CDH1
19 lung squamous cell carcinoma 28.6 TP53 NAPSA EGFR CEACAM5 CDH1
20 vulvar keratinizing squamous cell carcinoma 12.8
21 cervical keratinizing squamous cell carcinoma 12.6
22 cervical non-keratinizing squamous cell carcinoma 12.6
23 vulvar non-keratinizing squamous cell carcinoma 12.6
24 penile urethral cancer 10.6 KRT5 CDKN2A
25 male urethral cancer 10.6 KRT5 CDKN2A
26 prostate squamous cell carcinoma 10.5 TP53 CDKN2A
27 cervical basaloid squamous cell carcinoma 10.5 KRT7 CDKN2A
28 endometrial squamous cell carcinoma 10.5 TP53 CDKN2A
29 ureter squamous cell carcinoma 10.5 KRT7 KRT5
30 anal canal paget's disease 10.5 KRT7 CDKN2A
31 thymus basaloid carcinoma 10.5 NKX2-1 KRT5
32 cervical adenoid cystic carcinoma 10.5 KRT7 CDKN2A
33 atrophic vulva 10.5 KRT7 CDKN2A
34 basaloid lung carcinoma 10.5 TP53 KRT5
35 ceruminoma 10.5 KRT7 KRT5
36 spitz nevus 10.5 TP53 CDKN2A
37 microinvasive cervical squamous cell carcinoma 10.5 KRT7 KRT5
38 subareolar duct papillomatosis 10.5 KRT7 KRT5
39 nipple benign neoplasm 10.5 KRT7 KRT5
40 auditory system benign neoplasm 10.5 KRT7 KRT5
41 ceruminous adenocarcinoma 10.5 KRT7 KRT5
42 lymphoepithelioma-like thymic carcinoma 10.5 NUTM1 KRT5
43 middle ear adenoma 10.5 KRT7 KRT5
44 small cell carcinoma of the bladder 10.5 NKX2-1 KRT7
45 rete testis neoplasm 10.5 NKX2-1 KRT7
46 lung clear cell carcinoma 10.5 KRT7 KRT5
47 rete testis adenocarcinoma 10.5 NKX2-1 KRT7
48 gastric squamous cell carcinoma 10.5 KRT7 KRT5
49 bizarre leiomyoma 10.5 TP53 CDKN2A
50 malignant peritoneal mesothelioma 10.5 EGFR CDKN2A

Graphical network of the top 20 diseases related to Keratinizing Squamous Cell Carcinoma:



Diseases related to Keratinizing Squamous Cell Carcinoma

Symptoms & Phenotypes for Keratinizing Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Keratinizing Squamous Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.56 CDH1 CDKN2A EGFR KRT5 NKD1 NKX2-1
2 neoplasm MP:0002006 9.1 CDH1 CDKN2A EGFR NKX2-1 SMARCB1 TP53

Drugs & Therapeutics for Keratinizing Squamous Cell Carcinoma

Drugs for Keratinizing Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 2 51-21-8 3385
2
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4 Immunoglobulins Phase 2
5 Immunologic Factors Phase 2
6 Antibodies Phase 2
7 Immunoglobulins, Intravenous Phase 2
8 Endothelial Growth Factors Phase 2
9 Mitogens Phase 2
10 Antibodies, Monoclonal Phase 2
11 Angiogenesis Inhibitors Phase 2
12 Immunoglobulin G Phase 2
13 Immunosuppressive Agents Phase 2
14 Antimetabolites Phase 2
15 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Concurrent Chemoradiotherapy Using Three-Dimensional Conformal Radiotherapy (3D-CRT) or Intensity-Modulated Radiation Therapy (IMRT) + Bevacizumab (BV) for Locally or Regionally Advanced Nasopharyngeal Cancer Completed NCT00408694 Phase 2 Cisplatin;Fluorouracil

Search NIH Clinical Center for Keratinizing Squamous Cell Carcinoma

Genetic Tests for Keratinizing Squamous Cell Carcinoma

Anatomical Context for Keratinizing Squamous Cell Carcinoma

MalaCards organs/tissues related to Keratinizing Squamous Cell Carcinoma:

40
Cervix, Lung, Lymph Node, Skin, Endothelial, Thymus, Kidney

Publications for Keratinizing Squamous Cell Carcinoma

Articles related to Keratinizing Squamous Cell Carcinoma:

(show top 50) (show all 241)
# Title Authors PMID Year
1
EGFR and αvβ6 as Promising Targets for Molecular Imaging of Cutaneous and Mucosal Squamous Cell Carcinoma of the Head and Neck Region. 61
32516897 2020
2
SMARCB1 (INI-1)-Deficient Adenocarcinoma of the Sinonasal Tract: A Potentially Under-Recognized form of Sinonasal Adenocarcinoma with Occasional Yolk Sac Tumor-Like Features. 61
31468350 2020
3
Upper Gastrointestinal Bleeding Due to a Duodenal Metastasis from Primary Testicular Squamous Cell Carcinoma. 61
32392185 2020
4
Survival comparison of Three histological subtypes of lung squamous cell carcinoma: A population-based propensity score matching analysis. 61
32062199 2020
5
Tonsillar p16-Positive Follicular Dendritic Cell Sarcoma Mimicking HPV-Related Oropharyngeal Squamous Cell Carcinoma: A Case Report and Review of Reported Cases. 61
32189159 2020
6
Cervical Cancer Care Continuum in South India: Evidence from a Community-based Screening Program. 61
32175707 2020
7
Histological subtype remains a prognostic factor for survival in nasopharyngeal carcinoma patients. 61
31188486 2020
8
Comparative study on the mutational profile of adenocarcinoma and squamous cell carcinoma predominant histologic subtypes in Chinese non-small cell lung cancer patients. 61
31692283 2020
9
The effect of histological subtypes on survival outcome in nasopharyngeal carcinoma after extensive follow up. 61
32042784 2019
10
Phase I trial of belinostat in combination with 13-cis-retinoic acid in advanced solid tumor malignancies: a California Cancer Consortium NCI/CTEP sponsored trial. 61
31522242 2019
11
Lymph Node Status and Outcomes for Nasopharyngeal Carcinoma According to Histological Subtypes: A SEER Population-Based Retrospective Analysis. 61
31559602 2019
12
Telangiectatic Squamous Cell Carcinoma of Uterine Cervix: A Previously Undescribed Variant of Squamous Cell Carcinoma. 61
31651557 2019
13
Adenoid Basal Carcinoma of the Uterine Cervix in Association with Keratinizing Squamous Cell Carcinoma: a Rare Diagnosis. 61
31496589 2019
14
Nasopharyngeal undifferentiated carcinoma with sarcomatoid features: Pitfalls in the immunohistochemistry. 61
31427557 2019
15
Molecular profile of tongue cancer in an 18-year-old female patient with no recognizable risk factor. 61
31236464 2019
16
Radiation therapy for vaginal cancer in complete uterine prolapse with intrauterine adhesion: a case report. 61
31122220 2019
17
Lung squamous cell carcinoma: A postoperative recurrence analysis of keratinizing and nonkeratinizing subtypes. 61
30389303 2019
18
Rapid Progression of Intracranial Dural Metastases in a Patient with Carcinoma of Unknown Primary Site. 61
31572156 2019
19
[Clinicopathological characteristics of HPV(+) oropharyngeal squamous cell carcinoma]. 61
30695865 2019
20
Hypercalcemia and Extensive Chest Metastasis of Vulvar Squamous Cell Carcinoma. 61
31583214 2019
21
Patterns and Prognostic Value of Lymph Node Metastasis on Distant Metastasis and Survival in Nasopharyngeal Carcinoma: A Surveillance, Epidemiology, and End Results Study, 2006-2015. 61
31871457 2019
22
Adenosquamous carcinoma of the uterine cervix displaying tumor-associated tissue eosinophilia. 61
30800306 2019
23
Metastatic SMARCB1 (INI-1)-Deficient Sinonasal Carcinoma Diagnosed by Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA): A Potential Diagnostic Pitfall and Review of the Literature. 61
31132763 2019
24
Expression of PD-L1/PD-1 in lymphoepithelioma-like carcinoma of the thymus. 61
29973653 2018
25
Cyclooxygenase-2 Expression and Its Correlation with Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma. 61
30559850 2018
26
Correlation of P38 Mitogen-Activated Protein Kinase Expression to Clinical Stage in Nasopharyngeal Carcinoma. 61
30559847 2018
27
Primary Intrahepatic Squamous Cell Carcinoma with Histological Collision of Adenocarcinoma and Squamous Cell Carcinoma: A Case Report. 61
30287803 2018
28
Large cell neuroendocrine carcinoma of the maxillary sinus on fine needle aspiration cytology: Report of a rare case with a focus on pitfalls in diagnosis. 61
28905513 2018
29
Outcome of nasopharyngeal carcinoma in Finland: A nationwide study. 61
28686479 2018
30
[Prevalencia y genotipos del virus del papiloma humano en muestras de tejido laríngeo de pacientes con cáncer de laringe del noreste de México]. 61
30361714 2018
31
Oral Squamous Cell Carcinoma Found Inline with the Fields of Repeat Stereotactic Radiosurgery for Recurrent Trigeminal Neuralgia. 61
29545977 2018
32
Human papillomavirus (HPV) and Epstein-Barr virus (EBV) in keratinizing versus non- keratinizing squamous cell carcinoma of the oropharynx. 61
30455727 2018
33
Correlation of clinicopathologic features and lung squamous cell carcinoma subtypes according to the 2015 WHO classification. 61
28964610 2017
34
Squamous cell transformation and EGFR T790M mutation as acquired resistance mechanisms in a patient with lung adenocarcinoma treated with a tyrosine kinase inhibitor: A case report. 61
29113230 2017
35
Refining the Role of Lymph Node Biopsy in Survival for Patients with Nasopharyngeal Carcinoma: Population-Based Study from the Surveillance Epidemiology and End-Results Registry. 61
28681157 2017
36
Massive tumor embolism in the abdominal aorta from pulmonary squamous cell carcinoma: Case report and review of the literature. 61
28653784 2017
37
Carcinoma of the Middle Ear: A Review of the National Cancer Database. 61
28692593 2017
38
Sympathetic ophthalmia related to conjunctival invasive squamous-cell carcinoma. 61
28820163 2017
39
Chondrosarcoma-like metastasis from a poorly differentiated uterine cervical squamous cell carcinoma. A unique morphology and diagnostic pitfall in cytology. 61
28411397 2017
40
Pediatric laryngeal carcinoma in a heterozygous carrier of Fanconi anemia. 61
28139070 2017
41
Determination of p16 overexpression as an indicator of human papillomavirus infection in oral dysplasia and carcinoma. 61
28836534 2017
42
Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report. 61
28638233 2017
43
INI1 (SMARCB1)-Deficient Sinonasal Carcinoma: A Clinicopathologic Report of 2 Cases. 61
27644951 2017
44
[Clinicopathologic features and genetic profile of the redefined large cell lung carcinoma]. 61
28468033 2017
45
Global trends in nasopharyngeal cancer mortality since 1970 and predictions for 2020: Focus on low-risk areas. 61
28224615 2017
46
Primary histiocytic sarcoma of the uterine cervix: an extremely rare entity. 61
27828780 2017
47
An immunohistochemical analysis of lymphocytic infiltrations in canine skin cancers. 61
28525331 2017
48
A Rare Collision Tumour of Uterus- Squamous Cell Carcinoma and Endometrial Stromal Sarcoma. 61
28384878 2017
49
Endosonography and Confocal Endomicroscopy of Primary Keratinizing Squamous Cell Carcinoma of the Pancreas. 61
28184374 2017
50
[Spontaneous regression of lung cancer in an elderly patient: a case report]. 61
29212998 2017

Variations for Keratinizing Squamous Cell Carcinoma

Expression for Keratinizing Squamous Cell Carcinoma

Search GEO for disease gene expression data for Keratinizing Squamous Cell Carcinoma.

Pathways for Keratinizing Squamous Cell Carcinoma

Pathways related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.44 TP53 GNG7 EGFR CDKN2A CDH1
2
Show member pathways
12.32 TP53 SMARCB1 EGFR CDKN2A CDH1
3 11.59 TP53 EGFR CDKN2A
4 11.47 TP53 GNG7 EGFR CDH1
5 11.04 TP53 EGFR CDKN2A
6 10.79 TP53 EGFR CDKN2A CDH1

GO Terms for Keratinizing Squamous Cell Carcinoma

Biological processes related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.65 TP53 NKX2-1 EGFR CDKN2A CDH1
2 replicative senescence GO:0090399 9.16 TP53 CDKN2A
3 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.96 TP53 EGFR
4 cerebral cortex cell migration GO:0021795 8.62 NKX2-1 EGFR

Sources for Keratinizing Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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