MCID: KRT003
MIFTS: 36

Keratinizing Squamous Cell Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Keratinizing Squamous Cell Carcinoma

MalaCards integrated aliases for Keratinizing Squamous Cell Carcinoma:

Name: Keratinizing Squamous Cell Carcinoma 12 15 17
Squamous Cell Carcinoma, Keratinizing 12 70
Keratinizing Epidermoid Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5521
NCIt 50 C4105
SNOMED-CT 67 18048008
UMLS 70 C0334247

Summaries for Keratinizing Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris.

MalaCards based summary : Keratinizing Squamous Cell Carcinoma, also known as squamous cell carcinoma, keratinizing, is related to basaloid squamous cell carcinoma and schneiderian carcinoma. An important gene associated with Keratinizing Squamous Cell Carcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. The drugs Cisplatin and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include cervix, lymph node and endothelial, and related phenotypes are digestive/alimentary and neoplasm

Related Diseases for Keratinizing Squamous Cell Carcinoma

Diseases related to Keratinizing Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 479)
# Related Disease Score Top Affiliating Genes
1 basaloid squamous cell carcinoma 31.9 TP53 SYP KRT7 EGFR CDKN2A
2 schneiderian carcinoma 30.7 NUTM1 MAML2
3 gallbladder squamous cell carcinoma 30.7 KRT5 CEACAM5
4 pleomorphic adenoma carcinoma 30.6 TP53 MAML2
5 vulva squamous cell carcinoma 30.6 TP53 EGFR CDKN2A
6 pleomorphic adenoma 30.3 TP53 MAML2 KRT7 CDKN2A
7 vulvar intraepithelial neoplasia 30.2 TP53 CDKN2A CDH1
8 squamous cell carcinoma 30.1 TP53 KRT7 EGFR CEACAM5 CDKN2A CDH1
9 adenoid squamous cell carcinoma 30.1 KRT7 KRT5 CDH1
10 vulva cancer 30.1 TP53 KRT7 EGFR CEACAM5 CDKN2A
11 cervical squamous cell carcinoma 29.9 TP53 EGFR CDKN2A CDH1
12 in situ carcinoma 29.7 TP53 KRT5 EGFR CDKN2A CDH1
13 ductal carcinoma in situ 29.7 TP53 KRT5 EGFR CDKN2A CDH1
14 transitional cell carcinoma 29.7 TP53 KRT7 EGFR CDKN2A CDH1
15 adenoma 29.6 TP53 SYP KRT7 CDKN2A CDH1
16 adenocarcinoma 28.7 TP53 NKX2-1 NAPSA KRT7 EGFR CEACAM5
17 vulvar keratinizing squamous cell carcinoma 11.6
18 cervical keratinizing squamous cell carcinoma 11.6
19 cervical non-keratinizing squamous cell carcinoma 11.6
20 vulvar non-keratinizing squamous cell carcinoma 11.5
21 penile urethral cancer 10.4 KRT5 CDKN2A
22 male urethral cancer 10.4 KRT5 CDKN2A
23 cervical basaloid squamous cell carcinoma 10.4 KRT7 CDKN2A
24 basaloid lung carcinoma 10.4 TP53 KRT5
25 ureter squamous cell carcinoma 10.4 KRT7 KRT5
26 lymphoepithelioma-like thymic carcinoma 10.4 NUTM1 KRT5
27 anal canal paget's disease 10.4 KRT7 CDKN2A
28 human papillomavirus infectious disease 10.4 TP53 CDKN2A
29 spitz nevus 10.4 TP53 CDKN2A
30 ceruminoma 10.4 KRT7 KRT5
31 cervical adenoid cystic carcinoma 10.4 KRT7 CDKN2A
32 atrophic vulva 10.4 KRT7 CDKN2A
33 subareolar duct papillomatosis 10.4 KRT7 KRT5
34 nipple benign neoplasm 10.4 KRT7 KRT5
35 microinvasive cervical squamous cell carcinoma 10.4 KRT7 KRT5
36 ceruminous adenocarcinoma 10.4 KRT7 KRT5
37 pregnancy adenoma 10.4 TAAR6 KRT5
38 squamous cell papilloma 10.4 TP53 CDKN2A
39 lung clear cell carcinoma 10.4 KRT7 KRT5
40 breast hemangioma 10.4 TP53 KRT7
41 internal auditory canal lipoma 10.4 SMARCB1 NUTM1
42 malignant peritoneal mesothelioma 10.4 EGFR CDKN2A
43 gastric squamous cell carcinoma 10.4 KRT7 KRT5
44 gallbladder adenoma 10.4 KRT7 CDKN2A
45 bizarre leiomyoma 10.4 TP53 CDKN2A
46 intratubular embryonal carcinoma 10.4 TP53 KRT7
47 papillary transitional carcinoma 10.4 TP53 KRT7
48 squamous cell bile duct carcinoma 10.4 KRT7 KRT5
49 posterior pituitary gland neoplasm 10.4 SMARCB1 NKX2-1
50 adult malignant schwannoma 10.4 TP53 CDKN2A

Graphical network of the top 20 diseases related to Keratinizing Squamous Cell Carcinoma:



Diseases related to Keratinizing Squamous Cell Carcinoma

Symptoms & Phenotypes for Keratinizing Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Keratinizing Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 CDH1 CDKN2A EGFR KRT5 NKX2-1 SMARCB1
2 neoplasm MP:0002006 9.1 CDH1 CDKN2A EGFR NKX2-1 SMARCB1 TP53

Drugs & Therapeutics for Keratinizing Squamous Cell Carcinoma

Drugs for Keratinizing Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 4 15663-27-1 84093 441203 2767
2
Docetaxel Approved, Investigational Phase 4 114977-28-5 148124
3 Antimitotic Agents Phase 4
4 Tubulin Modulators Phase 4
5
Fluorouracil Approved Phase 2 51-21-8 3385
6
Bevacizumab Approved, Investigational Phase 2 216974-75-3
7 Angiogenesis Inhibitors Phase 2
8 Antineoplastic Agents, Immunological Phase 2
9 Antibodies Phase 2
10 Immunoglobulins, Intravenous Phase 2
11 Mitogens Phase 2
12 Immunoglobulin G Phase 2
13 Immunoglobulins Phase 2
14 Immunosuppressive Agents Phase 2
15 Immunologic Factors Phase 2
16 Antibodies, Monoclonal Phase 2
17 Antimetabolites Phase 2
18 Endothelial Growth Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase IV Clinical Study Evaluating The Efficacy of Chemoradiotherapy Following Neoadjuvant Treatment With Docetaxel and Cisplatin in Indifferentiated and Non-keratinized Squamous Cell Carcinoma of Nasopharynx Completed NCT00772681 Phase 4 docetaxel and cisplatin
2 A Phase II Study of Concurrent Chemoradiotherapy Using Three-Dimensional Conformal Radiotherapy (3D-CRT) or Intensity-Modulated Radiation Therapy (IMRT) + Bevacizumab (BV) for Locally or Regionally Advanced Nasopharyngeal Cancer Completed NCT00408694 Phase 2 Cisplatin;Fluorouracil

Search NIH Clinical Center for Keratinizing Squamous Cell Carcinoma

Genetic Tests for Keratinizing Squamous Cell Carcinoma

Anatomical Context for Keratinizing Squamous Cell Carcinoma

MalaCards organs/tissues related to Keratinizing Squamous Cell Carcinoma:

40
Cervix, Lymph Node, Endothelial, Lung, Thymus, Colon, Trachea

Publications for Keratinizing Squamous Cell Carcinoma

Articles related to Keratinizing Squamous Cell Carcinoma:

(show top 50) (show all 254)
# Title Authors PMID Year
1
Metastatic Patterns and Prognosis of de novo Metastatic Nasopharyngeal Carcinoma in the United States. 61
32833262 2021
2
Re-irradiation with Moderate Hypo-Fractionation Using Intensity Modulated Photon or Proton Radiation Therapy in Locally Recurrent Squamous Cell Carcinoma of Nasopharynx. 61
33781049 2021
3
Tonsillar p16-Positive Follicular Dendritic Cell Sarcoma Mimicking HPV-Related Oropharyngeal Squamous Cell Carcinoma: A Case Report and Review of Reported Cases. 61
32189159 2021
4
Oropharyngeal Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN): A Case Report and Literature Review. 61
33709305 2021
5
EGFR Protein Expression Relates with Tumor Histology, Methylation Status of EGFR and HPV16 E6 Viral Load in Oropharyngeal Carcinoma. 61
33428063 2021
6
A Poorly Differentiated Non-keratinizing Sinonasal Squamous Cell Carcinoma with a Novel ETV6-TNFRSF8 Fusion Gene. 61
33394379 2021
7
Image-guided interstitial brachytherapy boost for keratinizing squamous cell carcinoma of inferior wall of the nasopharynx. 61
33299579 2020
8
Tumor Embolism Through Right-to-Left Shunt Due to Venous Invasion of Esophageal Carcinoma. 61
33010722 2020
9
Malignant pleural neoplasm with both differentiation of epithelioid mesothelioma and squamous-cell carcinoma, a rare phenomena. 61
33347735 2020
10
Oropharyngeal carcinoma: A single institution study of 338 primaries with special reference to high-risk human papillomavirus-mediated carcinoma with aggressive behavior. 61
33113454 2020
11
Nonkeratinizing Nasopharyngeal Carcinoma, Undifferentiated Type With Trisomy 2: A Case Report and Short Review of Cytogenetic and Molecular Literature. 61
32755442 2020
12
Telangiectatic Squamous Cell Carcinoma of Uterine Cervix: A Previously Undescribed Variant of Squamous Cell Carcinoma. 61
31651557 2020
13
[Teicoplanin-induced hypersensitivity syndrome in a diabetic foot patient with malignant ulcer]. 61
32829619 2020
14
SMARCB1 (INI-1)-Deficient Adenocarcinoma of the Sinonasal Tract: A Potentially Under-Recognized form of Sinonasal Adenocarcinoma with Occasional Yolk Sac Tumor-Like Features. 61
31468350 2020
15
EGFR and αvβ6 as Promising Targets for Molecular Imaging of Cutaneous and Mucosal Squamous Cell Carcinoma of the Head and Neck Region. 61
32516897 2020
16
Upper Gastrointestinal Bleeding Due to a Duodenal Metastasis from Primary Testicular Squamous Cell Carcinoma. 61
32392185 2020
17
Survival comparison of Three histological subtypes of lung squamous cell carcinoma: A population-based propensity score matching analysis. 61
32062199 2020
18
Cervical Cancer Care Continuum in South India: Evidence from a Community-based Screening Program. 61
32175707 2020
19
Histological subtype remains a prognostic factor for survival in nasopharyngeal carcinoma patients. 61
31188486 2020
20
Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study. 61
32774641 2020
21
Comparative study on the mutational profile of adenocarcinoma and squamous cell carcinoma predominant histologic subtypes in Chinese non-small cell lung cancer patients. 61
31692283 2020
22
Comprehensive Molecular Characterizations of Chinese Patients With Different Subtypes of Lung Squamous Cell Carcinoma. 61
33363036 2020
23
The effect of histological subtypes on survival outcome in nasopharyngeal carcinoma after extensive follow up. 61
32042784 2019
24
Phase I trial of belinostat in combination with 13-cis-retinoic acid in advanced solid tumor malignancies: a California Cancer Consortium NCI/CTEP sponsored trial. 61
31522242 2019
25
Lymph Node Status and Outcomes for Nasopharyngeal Carcinoma According to Histological Subtypes: A SEER Population-Based Retrospective Analysis. 61
31559602 2019
26
Adenoid Basal Carcinoma of the Uterine Cervix in Association with Keratinizing Squamous Cell Carcinoma: a Rare Diagnosis. 61
31496589 2019
27
Nasopharyngeal undifferentiated carcinoma with sarcomatoid features: Pitfalls in the immunohistochemistry. 61
31427557 2019
28
Molecular profile of tongue cancer in an 18-year-old female patient with no recognizable risk factor. 61
31236464 2019
29
Lung squamous cell carcinoma: A postoperative recurrence analysis of keratinizing and nonkeratinizing subtypes. 61
30389303 2019
30
Radiation therapy for vaginal cancer in complete uterine prolapse with intrauterine adhesion: a case report. 61
31122220 2019
31
Rapid Progression of Intracranial Dural Metastases in a Patient with Carcinoma of Unknown Primary Site. 61
31572156 2019
32
[Clinicopathological characteristics of HPV(+) oropharyngeal squamous cell carcinoma]. 61
30695865 2019
33
Hypercalcemia and Extensive Chest Metastasis of Vulvar Squamous Cell Carcinoma. 61
31583214 2019
34
Patterns and Prognostic Value of Lymph Node Metastasis on Distant Metastasis and Survival in Nasopharyngeal Carcinoma: A Surveillance, Epidemiology, and End Results Study, 2006-2015. 61
31871457 2019
35
Metastatic SMARCB1 (INI-1)-Deficient Sinonasal Carcinoma Diagnosed by Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA): A Potential Diagnostic Pitfall and Review of the Literature. 61
31132763 2019
36
Adenosquamous carcinoma of the uterine cervix displaying tumor-associated tissue eosinophilia. 61
30800306 2019
37
Expression of PD-L1/PD-1 in lymphoepithelioma-like carcinoma of the thymus. 61
29973653 2018
38
Cyclooxygenase-2 Expression and Its Correlation with Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma. 61
30559850 2018
39
Correlation of P38 Mitogen-Activated Protein Kinase Expression to Clinical Stage in Nasopharyngeal Carcinoma. 61
30559847 2018
40
Primary Intrahepatic Squamous Cell Carcinoma with Histological Collision of Adenocarcinoma and Squamous Cell Carcinoma: A Case Report. 61
30287803 2018
41
Large cell neuroendocrine carcinoma of the maxillary sinus on fine needle aspiration cytology: Report of a rare case with a focus on pitfalls in diagnosis. 61
28905513 2018
42
Outcome of nasopharyngeal carcinoma in Finland: A nationwide study. 61
28686479 2018
43
Oral Squamous Cell Carcinoma Found Inline with the Fields of Repeat Stereotactic Radiosurgery for Recurrent Trigeminal Neuralgia. 61
29545977 2018
44
[Prevalencia y genotipos del virus del papiloma humano en muestras de tejido laríngeo de pacientes con cáncer de laringe del noreste de México]. 61
30361714 2018
45
Human papillomavirus (HPV) and Epstein-Barr virus (EBV) in keratinizing versus non- keratinizing squamous cell carcinoma of the oropharynx. 61
30455727 2018
46
Correlation of clinicopathologic features and lung squamous cell carcinoma subtypes according to the 2015 WHO classification. 61
28964610 2017
47
Squamous cell transformation and EGFR T790M mutation as acquired resistance mechanisms in a patient with lung adenocarcinoma treated with a tyrosine kinase inhibitor: A case report. 61
29113230 2017
48
Massive tumor embolism in the abdominal aorta from pulmonary squamous cell carcinoma: Case report and review of the literature. 61
28653784 2017
49
Refining the Role of Lymph Node Biopsy in Survival for Patients with Nasopharyngeal Carcinoma: Population-Based Study from the Surveillance Epidemiology and End-Results Registry. 61
28681157 2017
50
Carcinoma of the Middle Ear: A Review of the National Cancer Database. 61
28692593 2017

Variations for Keratinizing Squamous Cell Carcinoma

Expression for Keratinizing Squamous Cell Carcinoma

Search GEO for disease gene expression data for Keratinizing Squamous Cell Carcinoma.

Pathways for Keratinizing Squamous Cell Carcinoma

Pathways related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.44 TP53 GNG7 EGFR CDKN2A CDH1
2
Show member pathways
12.32 TP53 SMARCB1 EGFR CDKN2A CDH1
3 11.59 TP53 EGFR CDKN2A
4 11.47 TP53 GNG7 EGFR CDH1
5 11.04 TP53 EGFR CDKN2A
6 10.79 TP53 EGFR CDKN2A CDH1

GO Terms for Keratinizing Squamous Cell Carcinoma

Biological processes related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 replicative senescence GO:0090399 8.96 TP53 CDKN2A
2 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.62 TP53 EGFR

Molecular functions related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MDM2/MDM4 family protein binding GO:0097371 8.96 TP53 CDKN2A
2 p53 binding GO:0002039 8.8 TP53 SMARCB1 CDKN2A

Sources for Keratinizing Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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