MCID: KRT005
MIFTS: 52

Keratoacanthoma

Categories: Cancer diseases, Genetic diseases, Rare diseases, Skin diseases
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Aliases & Classifications for Keratoacanthoma

Summaries for Keratoacanthoma

MalaCards based summary: Keratoacanthoma, also known as well-differentiated squamous cell carcinoma, is related to muir-torre syndrome and cystadenocarcinoma, and has symptoms including pruritus and exanthema. An important gene associated with Keratoacanthoma is NOTCH1 (Notch Receptor 1), and among its related pathways/superpathways are ERK Signaling and Disease. The drugs Lidocaine and Anti-Arrhythmia Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and lymph node, and related phenotypes are Increased shRNA abundance (Z-score > 2) and neoplasm

Wikipedia: 75 Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) rapidly-growing skin... more...

Related Diseases for Keratoacanthoma

Diseases in the Keratoacanthoma family:

Familial Keratoacanthoma

Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 462)
# Related Disease Score Top Affiliating Genes
1 muir-torre syndrome 32.5 TP53 MSH2 MLH1
2 cystadenocarcinoma 30.8 TP53 CDKN1A BCL2
3 skin benign neoplasm 30.8 TP53 MSH2 MLH1 KRT14
4 suppressor of tumorigenicity 3 30.8 TP53 CDKN1A BCL2
5 necrotizing sialometaplasia 30.8 TP53 KRT15
6 skin carcinoma 30.6 TP53 NOTCH1 MSH2 KRT14 EGFR CTNNB1
7 laryngeal squamous cell carcinoma 30.5 TP53 MKI67 EGFR CDKN1A CDH1 BCL2
8 bowen's disease 30.5 MKI67 KRT10 IVL
9 pilomatrixoma 30.5 KRT17 KRT15 KRT14 CTNNB1
10 verrucous carcinoma 30.4 TP53 PIK3CA KRT14 EGFR CDH1
11 acanthoma 30.4 TP53 PIK3CA KRT10
12 lichen planus 30.3 TP53 KRT10 IVL GZMB FLG
13 esophagus adenocarcinoma 30.1 TP53 EGFR CTNNB1 CDH1
14 peutz-jeghers syndrome 30.1 TP53 EGFR CTNNB1
15 actinic keratosis 30.1 TP53 MKI67 KRT14 KRT10 IVL FLG
16 larynx cancer 30.1 TP53 MKI67 EGFR BCL2
17 alopecia 30.1 KRT15 KRT14 FLG CTNNB1
18 skin squamous cell carcinoma 30.0 TP53 MSH2 MLH1 KRT14 KRT10 IVL
19 adenoid squamous cell carcinoma 30.0 TP53 CDH1
20 sebaceous adenoma 30.0 MSH2 MLH1 KRT15 KRT14
21 malignant syringoma 30.0 KRT17 KRT15
22 cervical cancer 30.0 TP53 PIK3CA NOTCH1 KRT14 CTNNB1 CDKN1A
23 vulva squamous cell carcinoma 30.0 TP53 PIK3CA EGFR
24 laryngeal benign neoplasm 30.0 TP53 PIK3CA EGFR
25 keratinizing squamous cell carcinoma 29.9 TP53 PIK3CA EGFR CDH1
26 skin melanoma 29.9 TP53 PIK3CA CTNNB1 CDKN1A
27 papilloma 29.9 TP53 KRT14 KRT10 IVL FLG EGFR
28 keratosis, seborrheic 29.9 TP53 PIK3CA KRT17 KRT10 IVL
29 sebaceous adenocarcinoma 29.8 TP53 MSH2 MLH1 KRT14
30 nevus, epidermal 29.8 PIK3CA KRT10 IVL
31 keratosis 29.8 TP53 PIK3CA KRT17 KRT14 KRT10 IVL
32 human papillomavirus infectious disease 29.8 TP53 PIK3CA FLG EGFR CDKN1A
33 lynch syndrome 29.7 TP53 PIK3CA MSH2 MLH1 EGFR CTNNB1
34 contact dermatitis 29.7 KRT17 IVL FLG
35 inherited cancer-predisposing syndrome 29.7 TP53 MSH2 MLH1 EGFR CDH1
36 bap1 tumor predisposition syndrome 29.7 TP53 MSH2 MLH1 EGFR CDH1
37 leukemia, chronic myeloid 29.7 TP53 NOTCH1 GZMB EGFR CTNNB1 CDKN1A
38 clear cell acanthoma 29.7 KRT10 IVL FLG
39 epidermodysplasia verruciformis 1 29.6 TP53 NOTCH1 KRT14 IVL
40 melanoma 29.6 TP53 PIK3CA MLH1 MKI67 GZMB CTNNB1
41 squamous cell carcinoma 29.6 TP53 PIK3CA NOTCH2 NOTCH1 MKI67 KRT14
42 porokeratosis 29.6 TP53 KRT10 IVL FLG
43 psoriasis 29.5 KRT17 KRT15 KRT14 KRT10 IVL FLG
44 leukemia, chronic lymphocytic 29.5 TP53 NOTCH2 NOTCH1 GZMB EGFR CTNNB1
45 myeloma, multiple 29.5 TP53 PIK3CA NOTCH1 CDKN1A BCL2 BAK1
46 penile benign neoplasm 29.4 TP53 PIK3CA
47 adenoma 29.4 TP53 PIK3CA MSH2 MLH1 MKI67 CTNNB1
48 lip and oral cavity cancer 29.3 TP53 PIK3CA IVL EGFR CDH1
49 squamous cell carcinoma, head and neck 29.1 TP53 PIK3CA MLH1 EGFR CTNNB1 CDKN1A
50 lung cancer susceptibility 3 29.1 TP53 PIK3CA MLH1 EGFR CTNNB1 CDKN1A

Graphical network of the top 20 diseases related to Keratoacanthoma:



Diseases related to Keratoacanthoma

Symptoms & Phenotypes for Keratoacanthoma

UMLS symptoms related to Keratoacanthoma:


pruritus; exanthema

GenomeRNAi Phenotypes related to Keratoacanthoma according to GeneCards Suite gene sharing:

25 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.74 NOTCH2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.74 TP53
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.74 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.74 EGFR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.74 NOTCH2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.74 NOTCH2 TP53
7 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.74 TP53
8 Increased shRNA abundance (Z-score > 2) GR00366-A-184 9.74 TP53
9 Increased shRNA abundance (Z-score > 2) GR00366-A-187 9.74 NOTCH2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.74 NOTCH2 TP53
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.74 TP53
12 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.74 NOTCH2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-20 9.74 TP53
14 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.74 EGFR
15 Increased shRNA abundance (Z-score > 2) GR00366-A-211 9.74 NOTCH2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.74 EGFR
17 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.74 TP53
18 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.74 NOTCH2 TP53
19 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.74 EGFR
20 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.74 PIK3CA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-62 9.74 TP53
22 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.74 EGFR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.74 EGFR

MGI Mouse Phenotypes related to Keratoacanthoma:

45 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 10.51 BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
2 homeostasis/metabolism MP:0005376 10.48 BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
3 growth/size/body region MP:0005378 10.37 BCL2 CDH1 CDKN1A CTNNB1 EGFR IVL
4 endocrine/exocrine gland MP:0005379 10.32 BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
5 digestive/alimentary MP:0005381 10.32 BCL2 CDH1 CDKN1A CTNNB1 EGFR KRT14
6 cellular MP:0005384 10.31 BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
7 immune system MP:0005387 10.27 BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
8 normal MP:0002873 10.25 BAK1 CDH1 CTNNB1 EGFR IVL MKI67
9 pigmentation MP:0001186 10.21 BCL2 CTNNB1 EGFR KRT14 KRT17 NOTCH1
10 no phenotypic analysis MP:0003012 10.19 CDH1 CDKN1A CTNNB1 EGFR MKI67 NOTCH2
11 renal/urinary system MP:0005367 10.19 BAK1 BCL2 CDKN1A CTNNB1 EGFR NOTCH1
12 hearing/vestibular/ear MP:0005377 10.19 BAK1 BCL2 CDKN1A CTNNB1 EGFR KRT10
13 muscle MP:0005369 10.18 BCL2 CDKN1A CTNNB1 EGFR NOTCH1 NOTCH2
14 craniofacial MP:0005382 10.16 BCL2 CDKN1A CTNNB1 EGFR KRT10 KRT14
15 embryo MP:0005380 10.15 BCL2 CDH1 CDKN1A CTNNB1 EGFR NOTCH1
16 cardiovascular system MP:0005385 10.14 BCL2 CDH1 CDKN1A CTNNB1 EGFR IVL
17 limbs/digits/tail MP:0005371 10.11 BAK1 CDKN1A CTNNB1 EGFR KRT10 NOTCH2
18 adipose tissue MP:0005375 10.1 BCL2 CDKN1A EGFR IVL KRT14 PIK3CA
19 reproductive system MP:0005389 10.03 BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
20 hematopoietic system MP:0005397 9.97 BAK1 BCL2 CDKN1A CTNNB1 EGFR GZMB
21 respiratory system MP:0005388 9.92 CDKN1A CTNNB1 EGFR KRT14 MLH1 NOTCH1
22 mortality/aging MP:0010768 9.86 BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
23 integument MP:0010771 9.47 BCL2 CDH1 CDKN1A CTNNB1 EGFR KRT10

Drugs & Therapeutics for Keratoacanthoma

Drugs for Keratoacanthoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2 Anti-Arrhythmia Agents Phase 4
3 Sodium Channel Blockers Phase 4
4 Anesthetics, Local Phase 4
5 Anesthetics Phase 4
6 Diuretics, Potassium Sparing Phase 4
7
Nivolumab Approved Phase 2 946414-94-4
8
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
9 Immune Checkpoint Inhibitors Phase 2
10 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Use of Local Anesthetic in Intralesional Corticosteroid Injections; A Randomized, Double Blind Controlled Trial Completed NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
2 A Phase II Study of Talimogene Laherparepvec Followed by Talimogene Laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, and Other Rare Skin Tumors Recruiting NCT02978625 Phase 2
3 A Single Arm Phase 2 Study of Talimogene Laherparepvec in Patients With Cutaneous Squamous Cell Cancer Active, not recruiting NCT03714828 Phase 2 Injection of TVEC into target lesions - week 1-2;Injection of TVEC into target lesions 3wks after 1st injection;Injection of TVEC into target lesions 2wks after 2nd injection;Injection of TVEC into target lesions 2wks after 3rd injection
4 A Phase II Study of L19IL2/L19TNF in Patients With Skin Cancers Amenable to Intralesional Treatment Not yet recruiting NCT05329792 Phase 2 L19IL2/L19TNF

Search NIH Clinical Center for Keratoacanthoma

Cochrane evidence based reviews: keratoacanthoma

Genetic Tests for Keratoacanthoma

Anatomical Context for Keratoacanthoma

Organs/tissues related to Keratoacanthoma:

MalaCards : Skin, Tongue, Lymph Node, Lung, Cervix, Smooth Muscle, Thymus

Publications for Keratoacanthoma

Articles related to Keratoacanthoma:

(show top 50) (show all 2193)
# Title Authors PMID Year
1
Keratoacanthoma Shares Driver Mutations with Cutaneous Squamous Cell Carcinoma. 62 5
27283355 2016
2
Solitary subungual keratoacanthoma arising in an MSH2 germline mutation carrier: confirmation of a relationship by immunohistochemical analysis. 53 62
19602866 2009
3
Keratin and filaggrin expression in keratoacanthoma. 53 62
18005116 2008
4
Expression of apoptotic and cell proliferation regulatory proteins in keratoacanthomas and squamous cell carcinomas of the skin. 53 62
18079070 2008
5
A comparative study of granzyme B expression in keratoacanthoma and squamous cell carcinoma. 53 62
16952444 2006
6
Value of MLH1 and MSH2 mutations in the appearance of Muir-Torre syndrome phenotype in HNPCC patients presenting sebaceous gland tumors or keratoacanthomas. 53 62
16826164 2006
7
Transformation-specific matrix metalloproteinases, MMP-7 and MMP-13, are present in epithelial cells of keratoacanthomas. 53 62
16699496 2006
8
Possible key role of granzyme B in keratoacanthoma regression. 53 62
16497444 2006
9
Expression of keratin and involucrin in keratoacanthoma: an immunohistochemical aid to diagnosis. 53 62
15033195 2004
10
Cytokeratin 10 and Ki-67 nuclear marker expression in keratoacanthoma and squamous cell carcinoma. 53 62
15588557 2004
11
Expression of cell-cycle proteins p53, p21 (WAF-1), PCNA and Ki-67 in benign, premalignant and malignant skin lesions with implicated HPV involvement. 53 62
10429981 1999
12
Expression of trichohyalin in dermatological disorders: a comparative study with involucrin and filaggrin by immunohistochemical staining. 53 62
10228630 1999
13
Expression of bcl-2 antagonist bak in inflammatory and neoplastic skin diseases. 53 62
9415228 1997
14
Keratoacanthoma and squamous cell carcinoma: study of PCNA and Le(Y) expression. 53 62
9274958 1997
15
Human collagenase-3 is expressed in malignant squamous epithelium of the skin. 53 62
9242512 1997
16
Differential expression of desmosomal glycoproteins in keratoacanthoma and squamous cell carcinoma of the skin: an immunohistochemical aid to diagnosis. 53 62
8891017 1996
17
Proliferating cell nuclear antigen (PCNA) expression in pseudoepitheliomatous hyperplasia, keratoacanthoma and squamous cell carcinoma of the skin. 53 62
8893923 1996
18
Proliferating cell nuclear antigen immunostaining in keratoacanthoma and squamous cell carcinoma of the skin. 53 62
7617390 1994
19
Proliferating cell nuclear antigen distribution in keratoacanthoma and squamous cell carcinoma. 53 62
7507945 1993
20
'Anti-metastatic' nm23 gene product expression in keratoacanthoma and squamous cell carcinoma. 53 62
8358113 1993
21
Expression of ras proto-oncogene related protein p21 in normal human skin and cutaneous tumours. 53 62
1326835 1992
22
Pseudocarcinomatous Hyperplasia Masquerading as a Well-Differentiated Squamous Cell Carcinoma Associated With Primary Cutaneous Anaplastic Large-Cell Lymphoma. 62
36197055 2022
23
Radiographic features of subungual keratoacanthomas in dogs. 62
35576241 2022
24
An Updated Review of the Therapeutic Management of Keratoacanthomas. 62
36381181 2022
25
Simultaneous basal cell carcinoma and keratoacanthoma in a linear epidermal verrucous nevus. 62
36321345 2022
26
Keratoacanthoma-Like Squamous Cell Carcinoma. 62
36124548 2022
27
To treat or not to treat: PD-L1 inhibitor-induced keratoacanthoma and squamous cell carcinoma. 62
36394634 2022
28
Two birds with one stone: Successful treatment with methotrexate in a patient with generalized eruptive keratoacanthoma of Grzybowski and rheumatoid arthritis. 62
36018509 2022
29
Giant Keratoacanthoma of the Hand. 62
35321581 2022
30
Occurrence of voriconazole-induced cutaneous squamous cell carcinoma in Japan: data mining from different national pharmacovigilance databases. 62
36273254 2022
31
Squamous Cell Carcinoma at Split Thickness Skin Graft Donor Site: A Case Report and Review of the Literature. 62
36165213 2022
32
Therapeutic efficacy of topical imiquimod cream on keratoacanthoma: A retrospective single-center study. 62
34474080 2022
33
Low detection rate of human papillomavirus in patients with cutaneous squamous cell carcinoma and keratoacanthoma 62
36468731 2022
34
Radiographic characteristics of canine subungual keratoacanthoma. 62
35347820 2022
35
Rapid development of keratoacanthoma following chemical peel. 62
36052769 2022
36
The Janus face of keratoacanthoma - relevance for recognition as an occupational disease in Germany due to natural UV-radiation (BK 5103). 62
35691944 2022
37
The role of HPV in keratinocyte skin cancer development: A systematic review. 62
36000380 2022
38
Female Genital Schistosomiasis (FGS) Associated with Well-Differentiated Squamous Cell Carcinoma of the Vulva: A Case Report. 62
36062964 2022
39
A Unique Case of Squamous Cell Carcinoma Presenting Within a Lesion of Granuloma Annulare. 62
36110441 2022
40
CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications. 62
36010209 2022
41
Solitary pancreatic metastasis from squamous cell lung carcinoma: A case report and review of literature. 62
36051994 2022
42
Lower lip recurrent keratoacanthoma: A case report. 62
36051135 2022
43
Post-surgical eruptive keratoacanthoma: Koebner is not enough. 62
34363690 2022
44
A Case of Giant Proliferative Periocular Pyogenic Granuloma. 62
33179542 2022
45
Multiple eruptive squamoproliferative lesions during anti-PD1 immunotherapy for metastatic melanoma: Pathogenesis, immunohistochemical analysis and treatment. 62
35347815 2022
46
Cutaneous leishmaniasis over a tattoo mimicking keratoacanthoma in Southern Europe. 62
35030273 2022
47
Management of Pre-malignant and Malignant Non-melanoma Skin Cancers: A Study from a Tertiary Care Hospital of North India. 62
35965913 2022
48
Extraordinarily aggressive cutaneous sarcomatoid squamous cell carcinoma of the face: a case report. 62
35526843 2022
49
A rare case of axillary keratoacanthoma arising in hidradenitis suppurativa. 62
35146101 2022
50
Considerations in the management of keratoacanthoma. 62
34698376 2022

Variations for Keratoacanthoma

ClinVar genetic disease variations for Keratoacanthoma:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 NOTCH1 NM_017617.5(NOTCH1):c.2272G>T (p.Glu758Ter) SNV Pathogenic
1344732 GRCh37: 9:139407925-139407925
GRCh38: 9:136513473-136513473
2 NOTCH1 NM_017617.5(NOTCH1):c.3463C>T (p.Gln1155Ter) SNV Pathogenic
1344783 GRCh37: 9:139402454-139402454
GRCh38: 9:136508002-136508002
3 NOTCH2 NM_024408.4(NOTCH2):c.1243G>A (p.Asp415Asn) SNV Pathogenic
1344877 GRCh37: 1:120510721-120510721
GRCh38: 1:119968098-119968098
4 NOTCH2 NM_024408.4(NOTCH2):c.1211C>T (p.Pro404Leu) SNV Pathogenic
1344880 GRCh37: 1:120510753-120510753
GRCh38: 1:119968130-119968130
5 PIK3CA NM_006218.4(PIK3CA):c.353G>A (p.Gly118Asp) SNV Pathogenic
156446 rs587777790 GRCh37: 3:178917478-178917478
GRCh38: 3:179199690-179199690

Expression for Keratoacanthoma

Search GEO for disease gene expression data for Keratoacanthoma.

Pathways for Keratoacanthoma

Pathways related to Keratoacanthoma according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
2
Show member pathways
13.83 TP53 PIK3CA NOTCH2 NOTCH1 MSH2 MLH1
3 13.79 BCL2 CDH1 CDKN1A CTNNB1 EGFR GZMB
4
Show member pathways
13.65 PIK3CA NOTCH1 KRT17 KRT15 KRT14 KRT10
5
Show member pathways
12.92 TP53 PIK3CA GZMB EGFR CDKN1A BCL2
6
Show member pathways
12.86 TP53 PIK3CA CDKN1A BCL2 BAK1
7
Show member pathways
12.79 TP53 NOTCH2 NOTCH1 GZMB EGFR
8
Show member pathways
12.66 BAK1 BCL2 CDH1 CTNNB1 GZMB TP53
9 12.65 TP53 PIK3CA EGFR CTNNB1 CDKN1A CDH1
10
Show member pathways
12.57 KRT17 KRT15 KRT14 KRT10 IVL FLG
11
Show member pathways
12.55 TP53 PIK3CA MSH2 EGFR CTNNB1 CDKN1A
12 12.54 TP53 MSH2 MLH1 MKI67 CDKN1A
13
Show member pathways
12.51 TP53 PIK3CA EGFR CTNNB1 CDH1
14
Show member pathways
12.48 TP53 PIK3CA CTNNB1 CDH1 BCL2
15
Show member pathways
12.46 TP53 PIK3CA EGFR CTNNB1 BCL2
16
Show member pathways
12.39 TP53 CDKN1A BCL2 BAK1
17 12.31 PIK3CA EGFR CTNNB1 BCL2
18
Show member pathways
12.29 TP53 PIK3CA NOTCH2 NOTCH1 EGFR CTNNB1
19
Show member pathways
12.27 TP53 GZMB BCL2 BAK1
20
Show member pathways
12.27 TP53 PIK3CA MSH2 MLH1 EGFR CTNNB1
21
Show member pathways
12.25 NOTCH2 NOTCH1 GZMB EGFR
22
Show member pathways
12.24 BCL2 CDKN1A EGFR PIK3CA TP53
23
Show member pathways
12.15 PIK3CA EGFR CTNNB1 CDKN1A
24 12.14 TP53 PIK3CA NOTCH2 NOTCH1 CTNNB1 CDH1
25 12.13 CDH1 CDKN1A CTNNB1 EGFR MLH1 MSH2
26 12.09 NOTCH2 NOTCH1 CTNNB1 CDH1 BCL2
27 12.04 TP53 MSH2 EGFR CTNNB1 CDH1 BCL2
28 11.96 CDH1 CDKN1A CTNNB1 EGFR PIK3CA
29 11.95 NOTCH2 NOTCH1 CTNNB1 CDH1
30 11.94 BCL2 CTNNB1 NOTCH1 NOTCH2
31 11.91 NOTCH1 MSH2 MLH1 CDKN1A
32
Show member pathways
11.89 NOTCH1 CTNNB1 CDKN1A
33 11.89 TP53 PIK3CA CTNNB1 CDKN1A BCL2 BAK1
34 11.88 KRT14 IVL CTNNB1 BCL2
35 11.87 TP53 PIK3CA CDKN1A BCL2 BAK1
36 11.83 TP53 PIK3CA NOTCH1 CTNNB1
37 11.82 TP53 MSH2 MLH1
38 11.81 BAK1 BCL2 CDKN1A EGFR MLH1 MSH2
39 11.78 TP53 FLG BCL2
40 11.78 TP53 KRT17 KRT14 CDKN1A
41 11.76 PIK3CA CTNNB1 CDH1
42 11.74 TP53 CTNNB1 CDKN1A BCL2
43 11.73 NOTCH1 MKI67 CTNNB1 CDKN1A
44 11.71 EGFR CTNNB1 CDKN1A
45 11.69 TP53 PIK3CA NOTCH1
47 11.62 CDH1 GZMB PIK3CA
48 11.62 CDKN1A NOTCH1 NOTCH2
49 11.56 EGFR CTNNB1 CDH1
50
Show member pathways
11.53 BCL2 MLH1 MSH2

GO Terms for Keratoacanthoma

Cellular components related to Keratoacanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 9.35 NOTCH1 KRT17 KRT14 CTNNB1
2 cornified envelope GO:0001533 9.32 KRT17 KRT14 KRT10 IVL FLG

Biological processes related to Keratoacanthoma according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell population proliferation GO:0008285 10.33 TP53 NOTCH1 CTNNB1 CDKN1A BCL2 BAK1
2 response to xenobiotic stimulus GO:0009410 10.26 TP53 CTNNB1 CDH1 BCL2 BAK1
3 in utero embryonic development GO:0001701 10.25 TP53 NOTCH2 NOTCH1 MSH2 CTNNB1
4 regulation of cell cycle GO:0051726 10.24 TP53 MSH2 CDKN1A BCL2 BAK1
5 positive regulation of apoptotic process GO:0043065 10.22 BAK1 BCL2 CTNNB1 NOTCH1 NOTCH2 TP53
6 T cell differentiation in thymus GO:0033077 10.11 BCL2 CTNNB1 TP53
7 epithelial cell differentiation GO:0030855 10.11 KRT17 KRT15 KRT14 KRT10
8 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 10.04 BAK1 BCL2 TP53
9 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 10.03 TP53 MSH2 CDKN1A
10 peptide cross-linking GO:0018149 10.01 KRT10 IVL FLG
11 response to gamma radiation GO:0010332 10 BAK1 BCL2 TP53
12 release of cytochrome c from mitochondria GO:0001836 9.97 TP53 BCL2 BAK1
13 epidermis development GO:0008544 9.97 EGFR KRT10 KRT14 KRT15 NOTCH1
14 negative regulation of gene expression GO:0010629 9.97 BAK1 CDKN1A CTNNB1 NOTCH1 NOTCH2 PIK3CA
15 mesenchymal cell development GO:0014031 9.95 NOTCH1 BCL2
16 atrioventricular node development GO:0003162 9.95 NOTCH2 NOTCH1
17 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.95 MSH2 MLH1 BCL2 BAK1
18 cellular response to indole-3-methanol GO:0071681 9.93 CTNNB1 CDH1
19 negative regulation of anoikis GO:2000811 9.93 PIK3CA NOTCH1 BCL2
20 B cell lineage commitment GO:0002326 9.92 TP53 BCL2
21 positive regulation of isotype switching to IgA isotypes GO:0048298 9.91 MLH1 MSH2
22 cellular response to tumor cell GO:0071228 9.88 NOTCH2 NOTCH1
23 hair follicle morphogenesis GO:0031069 9.86 NOTCH1 KRT17 CTNNB1 BCL2
24 T cell lineage commitment GO:0002360 9.82 TP53 BCL2
25 response to UV-B GO:0010224 9.8 MSH2 IVL BCL2
26 signal transduction by p53 class mediator GO:0072331 9.77 CDKN1A TP53
27 somatic recombination of immunoglobulin gene segments GO:0016447 9.75 MSH2 MLH1
28 positive regulation of miRNA maturation GO:1903800 9.65 TP53 EGFR
29 keratinocyte differentiation GO:0030216 9.65 NOTCH1 KRT14 KRT10 IVL FLG
30 leukocyte homeostasis GO:0001776 9.62 BCL2 BAK1
31 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.61 MSH2 MLH1
32 cell population proliferation GO:0008283 9.23 TP53 NOTCH2 NOTCH1 MKI67 EGFR CTNNB1

Molecular functions related to Keratoacanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 10.06 TP53 NOTCH1 MSH2 MLH1 EGFR CTNNB1
2 protein phosphatase binding GO:0019903 9.7 BCL2 CTNNB1 EGFR TP53
3 guanine/thymine mispair binding GO:0032137 9.56 MSH2 MLH1
4 enzyme binding GO:0019899 9.47 TP53 NOTCH2 NOTCH1 MSH2 MLH1 EGFR
5 structural molecule activity GO:0005198 9.43 KRT17 KRT15 KRT14 KRT10 FLG

Sources for Keratoacanthoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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