Keratoacanthoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Keratoacanthoma, also known as well-differentiated squamous cell carcinoma, is related to muir-torre syndrome and cystadenocarcinoma, and has symptoms including pruritus and exanthema. An important gene associated with Keratoacanthoma is NOTCH1 (Notch Receptor 1), and among its related pathways/superpathways are ERK Signaling and Disease. The drugs Lidocaine and Anti-Arrhythmia Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and lymph node, and related phenotypes are Increased shRNA abundance (Z-score > 2) and neoplasm

Wikipedia: ⁷⁵ Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) rapidly-growing skin... more...

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Related Diseases for Keratoacanthoma

Diseases in the Keratoacanthoma family:

Familial Keratoacanthoma

Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 462)

#	Related Disease	Score	Top Affiliating Genes
1	muir-torre syndrome	32.5	TP53 MSH2 MLH1
2	cystadenocarcinoma	30.8	TP53 CDKN1A BCL2
3	skin benign neoplasm	30.8	TP53 MSH2 MLH1 KRT14
4	suppressor of tumorigenicity 3	30.8	TP53 CDKN1A BCL2
5	necrotizing sialometaplasia	30.8	TP53 KRT15
6	skin carcinoma	30.6	TP53 NOTCH1 MSH2 KRT14 EGFR CTNNB1
7	laryngeal squamous cell carcinoma	30.5	TP53 MKI67 EGFR CDKN1A CDH1 BCL2
8	bowen's disease	30.5	MKI67 KRT10 IVL
9	pilomatrixoma	30.5	KRT17 KRT15 KRT14 CTNNB1
10	verrucous carcinoma	30.4	TP53 PIK3CA KRT14 EGFR CDH1
11	acanthoma	30.4	TP53 PIK3CA KRT10
12	lichen planus	30.3	TP53 KRT10 IVL GZMB FLG
13	esophagus adenocarcinoma	30.1	TP53 EGFR CTNNB1 CDH1
14	peutz-jeghers syndrome	30.1	TP53 EGFR CTNNB1
15	actinic keratosis	30.1	TP53 MKI67 KRT14 KRT10 IVL FLG
16	larynx cancer	30.1	TP53 MKI67 EGFR BCL2
17	alopecia	30.1	KRT15 KRT14 FLG CTNNB1
18	skin squamous cell carcinoma	30.0	TP53 MSH2 MLH1 KRT14 KRT10 IVL
19	adenoid squamous cell carcinoma	30.0	TP53 CDH1
20	sebaceous adenoma	30.0	MSH2 MLH1 KRT15 KRT14
21	malignant syringoma	30.0	KRT17 KRT15
22	cervical cancer	30.0	TP53 PIK3CA NOTCH1 KRT14 CTNNB1 CDKN1A
23	vulva squamous cell carcinoma	30.0	TP53 PIK3CA EGFR
24	laryngeal benign neoplasm	30.0	TP53 PIK3CA EGFR
25	keratinizing squamous cell carcinoma	29.9	TP53 PIK3CA EGFR CDH1
26	skin melanoma	29.9	TP53 PIK3CA CTNNB1 CDKN1A
27	papilloma	29.9	TP53 KRT14 KRT10 IVL FLG EGFR
28	keratosis, seborrheic	29.9	TP53 PIK3CA KRT17 KRT10 IVL
29	sebaceous adenocarcinoma	29.8	TP53 MSH2 MLH1 KRT14
30	nevus, epidermal	29.8	PIK3CA KRT10 IVL
31	keratosis	29.8	TP53 PIK3CA KRT17 KRT14 KRT10 IVL
32	human papillomavirus infectious disease	29.8	TP53 PIK3CA FLG EGFR CDKN1A
33	lynch syndrome	29.7	TP53 PIK3CA MSH2 MLH1 EGFR CTNNB1
34	contact dermatitis	29.7	KRT17 IVL FLG
35	inherited cancer-predisposing syndrome	29.7	TP53 MSH2 MLH1 EGFR CDH1
36	bap1 tumor predisposition syndrome	29.7	TP53 MSH2 MLH1 EGFR CDH1
37	leukemia, chronic myeloid	29.7	TP53 NOTCH1 GZMB EGFR CTNNB1 CDKN1A
38	clear cell acanthoma	29.7	KRT10 IVL FLG
39	epidermodysplasia verruciformis 1	29.6	TP53 NOTCH1 KRT14 IVL
40	melanoma	29.6	TP53 PIK3CA MLH1 MKI67 GZMB CTNNB1
41	squamous cell carcinoma	29.6	TP53 PIK3CA NOTCH2 NOTCH1 MKI67 KRT14
42	porokeratosis	29.6	TP53 KRT10 IVL FLG
43	psoriasis	29.5	KRT17 KRT15 KRT14 KRT10 IVL FLG
44	leukemia, chronic lymphocytic	29.5	TP53 NOTCH2 NOTCH1 GZMB EGFR CTNNB1
45	myeloma, multiple	29.5	TP53 PIK3CA NOTCH1 CDKN1A BCL2 BAK1
46	penile benign neoplasm	29.4	TP53 PIK3CA
47	adenoma	29.4	TP53 PIK3CA MSH2 MLH1 MKI67 CTNNB1
48	lip and oral cavity cancer	29.3	TP53 PIK3CA IVL EGFR CDH1
49	squamous cell carcinoma, head and neck	29.1	TP53 PIK3CA MLH1 EGFR CTNNB1 CDKN1A
50	lung cancer susceptibility 3	29.1	TP53 PIK3CA MLH1 EGFR CTNNB1 CDKN1A

Graphical network of the top 20 diseases related to Keratoacanthoma:

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Symptoms & Phenotypes for Keratoacanthoma

UMLS symptoms related to Keratoacanthoma:

pruritus; exanthema

GenomeRNAi Phenotypes related to Keratoacanthoma according to GeneCards Suite gene sharing:

²⁵ (show all 23)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-107	9.74	NOTCH2
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-12	9.74	TP53
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	9.74	TP53
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	9.74	EGFR
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-130	9.74	NOTCH2
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-132	9.74	NOTCH2 TP53
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-169	9.74	TP53
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-184	9.74	TP53
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-187	9.74	NOTCH2
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	9.74	NOTCH2 TP53
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	9.74	TP53
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-198	9.74	NOTCH2
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-20	9.74	TP53
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-21	9.74	EGFR
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-211	9.74	NOTCH2
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	9.74	EGFR
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-35	9.74	TP53
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-39	9.74	NOTCH2 TP53
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.74	EGFR
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-60	9.74	PIK3CA
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-62	9.74	TP53
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.74	EGFR
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-91	9.74	EGFR

MGI Mouse Phenotypes related to Keratoacanthoma:

⁴⁵ (show all 23)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	10.51	BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
2	homeostasis/metabolism	MP:0005376	10.48	BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
3	growth/size/body region	MP:0005378	10.37	BCL2 CDH1 CDKN1A CTNNB1 EGFR IVL
4	endocrine/exocrine gland	MP:0005379	10.32	BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
5	digestive/alimentary	MP:0005381	10.32	BCL2 CDH1 CDKN1A CTNNB1 EGFR KRT14
6	cellular	MP:0005384	10.31	BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
7	immune system	MP:0005387	10.27	BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
8	normal	MP:0002873	10.25	BAK1 CDH1 CTNNB1 EGFR IVL MKI67
9	pigmentation	MP:0001186	10.21	BCL2 CTNNB1 EGFR KRT14 KRT17 NOTCH1
10	no phenotypic analysis	MP:0003012	10.19	CDH1 CDKN1A CTNNB1 EGFR MKI67 NOTCH2
11	renal/urinary system	MP:0005367	10.19	BAK1 BCL2 CDKN1A CTNNB1 EGFR NOTCH1
12	hearing/vestibular/ear	MP:0005377	10.19	BAK1 BCL2 CDKN1A CTNNB1 EGFR KRT10
13	muscle	MP:0005369	10.18	BCL2 CDKN1A CTNNB1 EGFR NOTCH1 NOTCH2
14	craniofacial	MP:0005382	10.16	BCL2 CDKN1A CTNNB1 EGFR KRT10 KRT14
15	embryo	MP:0005380	10.15	BCL2 CDH1 CDKN1A CTNNB1 EGFR NOTCH1
16	cardiovascular system	MP:0005385	10.14	BCL2 CDH1 CDKN1A CTNNB1 EGFR IVL
17	limbs/digits/tail	MP:0005371	10.11	BAK1 CDKN1A CTNNB1 EGFR KRT10 NOTCH2
18	adipose tissue	MP:0005375	10.1	BCL2 CDKN1A EGFR IVL KRT14 PIK3CA
19	reproductive system	MP:0005389	10.03	BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
20	hematopoietic system	MP:0005397	9.97	BAK1 BCL2 CDKN1A CTNNB1 EGFR GZMB
21	respiratory system	MP:0005388	9.92	CDKN1A CTNNB1 EGFR KRT14 MLH1 NOTCH1
22	mortality/aging	MP:0010768	9.86	BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
23	integument	MP:0010771	9.47	BCL2 CDH1 CDKN1A CTNNB1 EGFR KRT10

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Drugs & Therapeutics for Keratoacanthoma

Drugs for Keratoacanthoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

2

Anti-Arrhythmia Agents

Phase 4

3

Sodium Channel Blockers

Phase 4

4

Anesthetics, Local

Phase 4

5

Anesthetics

Phase 4

6

Diuretics, Potassium Sparing

Phase 4

7

Nivolumab

Approved

Phase 2

946414-94-4

8

Talimogene laherparepvec

Approved, Experimental, Investigational

Phase 2

1187560-31-1

9

Immune Checkpoint Inhibitors

Phase 2

10

Antineoplastic Agents, Immunological

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	The Use of Local Anesthetic in Intralesional Corticosteroid Injections; A Randomized, Double Blind Controlled Trial	Completed	NCT03630198	Phase 4	Corticosteroid with lidocaine;Corticosteroid with normal saline
2	A Phase II Study of Talimogene Laherparepvec Followed by Talimogene Laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, and Other Rare Skin Tumors	Recruiting	NCT02978625	Phase 2
3	A Single Arm Phase 2 Study of Talimogene Laherparepvec in Patients With Cutaneous Squamous Cell Cancer	Active, not recruiting	NCT03714828	Phase 2	Injection of TVEC into target lesions - week 1-2;Injection of TVEC into target lesions 3wks after 1st injection;Injection of TVEC into target lesions 2wks after 2nd injection;Injection of TVEC into target lesions 2wks after 3rd injection
4	A Phase II Study of L19IL2/L19TNF in Patients With Skin Cancers Amenable to Intralesional Treatment	Not yet recruiting	NCT05329792	Phase 2	L19IL2/L19TNF

Search NIH Clinical Center for Keratoacanthoma

Cochrane evidence based reviews: keratoacanthoma

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Genetic Tests for Keratoacanthoma

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Anatomical Context for Keratoacanthoma

Organs/tissues related to Keratoacanthoma:

MalaCards : Skin, Tongue, Lymph Node, Lung, Cervix, Smooth Muscle, Thymus

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Publications for Keratoacanthoma

Articles related to Keratoacanthoma:

(show top 50) (show all 2193)

#	Title	Authors	PMID	Year
1	Keratoacanthoma Shares Driver Mutations with Cutaneous Squamous Cell Carcinoma. ⁶² ⁵	Lim YH...Ko CJ	27283355	2016
2	Solitary subungual keratoacanthoma arising in an MSH2 germline mutation carrier: confirmation of a relationship by immunohistochemical analysis. ⁵³ ⁶²	Stoebner PE...Meunier L	19602866	2009
3	Keratin and filaggrin expression in keratoacanthoma. ⁵³ ⁶²	Ito Y...Mizutani H	18005116	2008
4	Expression of apoptotic and cell proliferation regulatory proteins in keratoacanthomas and squamous cell carcinomas of the skin. ⁵³ ⁶²	Ribeiro D...Marques ME	18079070	2008
5	A comparative study of granzyme B expression in keratoacanthoma and squamous cell carcinoma. ⁵³ ⁶²	Batinac T...Zauhar G	16952444	2006
6	Value of MLH1 and MSH2 mutations in the appearance of Muir-Torre syndrome phenotype in HNPCC patients presenting sebaceous gland tumors or keratoacanthomas. ⁵³ ⁶²	Ponti G...Seidenari S	16826164	2006
7	Transformation-specific matrix metalloproteinases, MMP-7 and MMP-13, are present in epithelial cells of keratoacanthomas. ⁵³ ⁶²	Kuivanen TT...Saarialho-Kere UK	16699496	2006
8	Possible key role of granzyme B in keratoacanthoma regression. ⁵³ ⁶²	Batinac T...Hadzisejdic I	16497444	2006
9	Expression of keratin and involucrin in keratoacanthoma: an immunohistochemical aid to diagnosis. ⁵³ ⁶²	Ichikawa E...Watanabe S	15033195	2004
10	Cytokeratin 10 and Ki-67 nuclear marker expression in keratoacanthoma and squamous cell carcinoma. ⁵³ ⁶²	Basta-Juzbasic A...Loncaric D	15588557	2004
11	Expression of cell-cycle proteins p53, p21 (WAF-1), PCNA and Ki-67 in benign, premalignant and malignant skin lesions with implicated HPV involvement. ⁵³ ⁶²	Lu S...Syrjanen S	10429981	1999
12	Expression of trichohyalin in dermatological disorders: a comparative study with involucrin and filaggrin by immunohistochemical staining. ⁵³ ⁶²	Lee SC...Kim YP	10228630	1999
13	Expression of bcl-2 antagonist bak in inflammatory and neoplastic skin diseases. ⁵³ ⁶²	Tomkova H...Arata J	9415228	1997
14	Keratoacanthoma and squamous cell carcinoma: study of PCNA and Le(Y) expression. ⁵³ ⁶²	Tsuji T	9274958	1997
15	Human collagenase-3 is expressed in malignant squamous epithelium of the skin. ⁵³ ⁶²	Airola K...Saarialho-Kere UK	9242512	1997
16	Differential expression of desmosomal glycoproteins in keratoacanthoma and squamous cell carcinoma of the skin: an immunohistochemical aid to diagnosis. ⁵³ ⁶²	Krunic AL...Cvijetic OB	8891017	1996
17	Proliferating cell nuclear antigen (PCNA) expression in pseudoepitheliomatous hyperplasia, keratoacanthoma and squamous cell carcinoma of the skin. ⁵³ ⁶²	Li J...Lee YS	8893923	1996
18	Proliferating cell nuclear antigen immunostaining in keratoacanthoma and squamous cell carcinoma of the skin. ⁵³ ⁶²	Royds JA...Bleehen SS	7617390	1994
19	Proliferating cell nuclear antigen distribution in keratoacanthoma and squamous cell carcinoma. ⁵³ ⁶²	Phillips P...Helm KF	7507945	1993
20	'Anti-metastatic' nm23 gene product expression in keratoacanthoma and squamous cell carcinoma. ⁵³ ⁶²	Stephenson TJ...Rees RC	8358113	1993
21	Expression of ras proto-oncogene related protein p21 in normal human skin and cutaneous tumours. ⁵³ ⁶²	Tanikawa E...Sasai Y	1326835	1992
22	Pseudocarcinomatous Hyperplasia Masquerading as a Well-Differentiated Squamous Cell Carcinoma Associated With Primary Cutaneous Anaplastic Large-Cell Lymphoma. ⁶²	LaTour D...Elsensohn A	36197055	2022
23	Radiographic features of subungual keratoacanthomas in dogs. ⁶²	O'Toole CJ...Le Roux AB	35576241	2022
24	An Updated Review of the Therapeutic Management of Keratoacanthomas. ⁶²	Ambur A...Nathoo R	36381181	2022
25	Simultaneous basal cell carcinoma and keratoacanthoma in a linear epidermal verrucous nevus. ⁶²	Santos-Coelho M...Carvalho RA	36321345	2022
26	Keratoacanthoma-Like Squamous Cell Carcinoma. ⁶²	Oon HH...Cheong CT	36124548	2022
27	To treat or not to treat: PD-L1 inhibitor-induced keratoacanthoma and squamous cell carcinoma. ⁶²	Poole M...Alhatem A	36394634	2022
28	Two birds with one stone: Successful treatment with methotrexate in a patient with generalized eruptive keratoacanthoma of Grzybowski and rheumatoid arthritis. ⁶²	Federica F...Bardazzi F	36018509	2022
29	Giant Keratoacanthoma of the Hand. ⁶²	Prezzi T...Heck R	35321581	2022
30	Occurrence of voriconazole-induced cutaneous squamous cell carcinoma in Japan: data mining from different national pharmacovigilance databases. ⁶²	Tanaka H...Ishii T	36273254	2022
31	Squamous Cell Carcinoma at Split Thickness Skin Graft Donor Site: A Case Report and Review of the Literature. ⁶²	McCormick M...Miotke S	36165213	2022
32	Therapeutic efficacy of topical imiquimod cream on keratoacanthoma: A retrospective single-center study. ⁶²	Lee JW...Jo SJ	34474080	2022
33	Low detection rate of human papillomavirus in patients with cutaneous squamous cell carcinoma and keratoacanthoma ⁶²	Baek YS...Kim C	36468731	2022
34	Radiographic characteristics of canine subungual keratoacanthoma. ⁶²	Toshima A...Murakami M	35347820	2022
35	Rapid development of keratoacanthoma following chemical peel. ⁶²	Simonsen AB...Zachariae C	36052769	2022
36	The Janus face of keratoacanthoma - relevance for recognition as an occupational disease in Germany due to natural UV-radiation (BK 5103). ⁶²	Gina M...Fartasch M	35691944	2022
37	The role of HPV in keratinocyte skin cancer development: A systematic review. ⁶²	Neagu N...Conforti C	36000380	2022
38	Female Genital Schistosomiasis (FGS) Associated with Well-Differentiated Squamous Cell Carcinoma of the Vulva: A Case Report. ⁶²	Ibrahim R...Abdullahi YM	36062964	2022
39	A Unique Case of Squamous Cell Carcinoma Presenting Within a Lesion of Granuloma Annulare. ⁶²	Zabel ML...Stephany M	36110441	2022
40	CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications. ⁶²	Bang S...Paik S	36010209	2022
41	Solitary pancreatic metastasis from squamous cell lung carcinoma: A case report and review of literature. ⁶²	Rais K...Ismaili Z	36051994	2022
42	Lower lip recurrent keratoacanthoma: A case report. ⁶²	Liu XG...Wang XX	36051135	2022
43	Post-surgical eruptive keratoacanthoma: Koebner is not enough. ⁶²	Gualdi G...Amerio P	34363690	2022
44	A Case of Giant Proliferative Periocular Pyogenic Granuloma. ⁶²	Zehra F...Jagadeesan J	33179542	2022
45	Multiple eruptive squamoproliferative lesions during anti-PD1 immunotherapy for metastatic melanoma: Pathogenesis, immunohistochemical analysis and treatment. ⁶²	Star P...Martin LK	35347815	2022
46	Cutaneous leishmaniasis over a tattoo mimicking keratoacanthoma in Southern Europe. ⁶²	Prados-Carmona A...Navarro-Trivino FJ	35030273	2022
47	Management of Pre-malignant and Malignant Non-melanoma Skin Cancers: A Study from a Tertiary Care Hospital of North India. ⁶²	Bhat YJ...Yaseen A	35965913	2022
48	Extraordinarily aggressive cutaneous sarcomatoid squamous cell carcinoma of the face: a case report. ⁶²	Lee Y...Park H	35526843	2022
49	A rare case of axillary keratoacanthoma arising in hidradenitis suppurativa. ⁶²	Chen JY...Wei ML	35146101	2022
50	Considerations in the management of keratoacanthoma. ⁶²	Mazzoni D...Muir J	34698376	2022

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Genes for Keratoacanthoma

Genes related to Keratoacanthoma (3 elite genes):

(show all 42)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	NOTCH1	Notch Receptor 1	Protein Coding	404.83	Pathogenic ⁵ DISEASES inferred ¹⁴	27283355
2	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	404.39	Pathogenic ⁵ DISEASES inferred ¹⁴	27283355
3	NOTCH2	Notch Receptor 2	Protein Coding	404.3	Pathogenic ⁵ DISEASES inferred ¹⁴	27283355
4	MSH2	MutS Homolog 2	Protein Coding	22.91	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16826164 19602866 11859205
5	KRT17	Keratin 17	Protein Coding	18.72	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18005116
6	KRT10	Keratin 10	Protein Coding	18.52	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15588557
7	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	16.94	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9415228
8	GZMB	Granzyme B	Protein Coding	16	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16497444 16952444
9	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	14.77	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10429981 1326835
10	MKI67	Marker Of Proliferation Ki-67	Protein Coding	14.71	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15588557 8600794 10429981 (more) 15143984 9653912
11	TP53	Tumor Protein P53	Protein Coding	14.38	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
12	MLH1	MutL Homolog 1	Protein Coding	13.87	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16826164 11859205
13	KRT14	Keratin 14	Protein Coding	12.78	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
14	EGFR	Epidermal Growth Factor Receptor	Protein Coding	12.67	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
15	KRT15	Keratin 15	Protein Coding	12.66	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
16	CTNNB1	Catenin Beta 1	Protein Coding	12.17	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
17	IVL	Involucrin	Protein Coding	12.15	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15033195 10228630
18	CDH1	Cadherin 1	Protein Coding	12.09	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
19	BCL2	BCL2 Apoptosis Regulator	Protein Coding	12.02	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
20	FLG	Filaggrin	Protein Coding	11.95	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
21	KRT16	Keratin 16	Protein Coding	11.75	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
22	CD1A	CD1a Molecule	Protein Coding	11.59	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
23	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	11.56	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
24	DSG1	Desmoglein 1	Protein Coding	11.55	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
25	CASP3	Caspase 3	Protein Coding	11.44	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
26	IL3RA	Interleukin 3 Receptor Subunit Alpha	Protein Coding	11.32	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
27	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	11.31	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
28	HIPK2	Homeodomain Interacting Protein Kinase 2	Protein Coding	11.13	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
29	RBP1	Retinol Binding Protein 1	Protein Coding	11.1	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
30	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	11.05	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
31	CRABP2	Cellular Retinoic Acid Binding Protein 2	Protein Coding	10.95	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
32	BCL2L1	BCL2 Like 1	Protein Coding	10.94	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
33	TP63	Tumor Protein P63	Protein Coding	10.83	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
34	DSG2	Desmoglein 2	Protein Coding	10.82	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
35	CD44	CD44 Molecule (Indian Blood Group)	Protein Coding	10.81	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
36	AREG	Amphiregulin	Protein Coding	10.8	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
37	KRT19	Keratin 19	Protein Coding	10.69	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
38	SDC1	Syndecan 1	Protein Coding	10.66	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
39	CRABP1	Cellular Retinoic Acid Binding Protein 1	Protein Coding	10.49	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
40	KRT8	Keratin 8	Protein Coding	10.24	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
41	OSM	Oncostatin M	Protein Coding	10.04	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
42	DSG3	Desmoglein 3	Protein Coding	8.62	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8891017

Sources

Variations for Keratoacanthoma

ClinVar genetic disease variations for Keratoacanthoma:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	NOTCH1	NM_017617.5(NOTCH1):c.2272G>T (p.Glu758Ter)	SNV	Pathogenic	1344732		GRCh37: 9:139407925-139407925 GRCh38: 9:136513473-136513473
2	NOTCH1	NM_017617.5(NOTCH1):c.3463C>T (p.Gln1155Ter)	SNV	Pathogenic	1344783		GRCh37: 9:139402454-139402454 GRCh38: 9:136508002-136508002
3	NOTCH2	NM_024408.4(NOTCH2):c.1243G>A (p.Asp415Asn)	SNV	Pathogenic	1344877		GRCh37: 1:120510721-120510721 GRCh38: 1:119968098-119968098
4	NOTCH2	NM_024408.4(NOTCH2):c.1211C>T (p.Pro404Leu)	SNV	Pathogenic	1344880		GRCh37: 1:120510753-120510753 GRCh38: 1:119968130-119968130
5	PIK3CA	NM_006218.4(PIK3CA):c.353G>A (p.Gly118Asp)	SNV	Pathogenic	156446	rs587777790	GRCh37: 3:178917478-178917478 GRCh38: 3:179199690-179199690

Sources

Expression for Keratoacanthoma

Search GEO for disease gene expression data for Keratoacanthoma.

Sources

Pathways for Keratoacanthoma

Pathways related to Keratoacanthoma according to GeneCards Suite gene sharing:

(show top 50) (show all 69)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.85	BAK1 BCL2 CDH1 CDKN1A CTNNB1 EGFR
2	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.83	TP53 PIK3CA NOTCH2 NOTCH1 MSH2 MLH1
3	Signal Transduction ⁶⁶	13.79	BCL2 CDH1 CDKN1A CTNNB1 EGFR GZMB
4	Nervous system development ⁶⁶ Show member pathways Axon guidance ⁶⁶ Developmental Biology ⁶⁶	13.65	PIK3CA NOTCH1 KRT17 KRT15 KRT14 KRT10
5	TNFR1 Pathway ⁶⁴ Show member pathways Apoptosis ⁷⁴ Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis modulation by HSP70 ⁷⁴ Apoptosis through Death Receptors ⁶⁴ Apoptotic Pathways Triggered By HIV1 ⁶⁴ Ceramide signaling pathway ⁶¹ DR3 Signaling ⁶⁴ GITR Pathway ⁶⁴ HIV-1 Nef: Negative effector of Fas and TNF-alpha ⁶¹ Stimulation of the cell death response by PAK-2p34 ⁶⁶ TNF Signaling ⁶⁴ TNF-related weak inducer of apoptosis (TWEAK) signaling pathway ⁷⁴ TRAIL Pathway ⁶⁴ TWEAK Pathway ⁶⁴	12.92	TP53 PIK3CA GZMB EGFR CDKN1A BCL2
6	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.86	TP53 PIK3CA CDKN1A BCL2 BAK1
7	Pre-NOTCH Expression and Processing ⁶⁶ Show member pathways Defective LFNG causes SCDO3 ⁶⁶ Pre-NOTCH Processing in Golgi ⁶⁶ Pre-NOTCH Processing in the Endoplasmic Reticulum ⁶⁶ Pre-NOTCH Transcription and Translation ⁶⁶ Signaling by NOTCH ⁶⁶	12.79	TP53 NOTCH2 NOTCH1 GZMB EGFR
8	Programmed Cell Death ⁶⁶ Show member pathways Apoptosis ⁶⁶	12.66	BAK1 BCL2 CDH1 CTNNB1 GZMB TP53
9	Malignant pleural mesothelioma ⁷⁴	12.65	TP53 PIK3CA EGFR CTNNB1 CDKN1A CDH1
10	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	12.57	KRT17 KRT15 KRT14 KRT10 IVL FLG
11	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.55	TP53 PIK3CA MSH2 EGFR CTNNB1 CDKN1A
12	DNA Damage ³	12.54	TP53 MSH2 MLH1 MKI67 CDKN1A
13	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ⁶¹	12.51	TP53 PIK3CA EGFR CTNNB1 CDH1
14	Hepatocyte growth factor receptor signaling ⁷⁴ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development HGF signaling pathway ²² Development Neurotrophin family signaling ²² Drug-mediated inhibition of MET activation ⁶⁶ MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ PLC-gamma1 signalling ⁶⁶ Trk receptor signaling mediated by PI3K and PLC-gamma ⁶¹ TRKA activation by NGF ⁶⁶	12.48	TP53 PIK3CA CTNNB1 CDH1 BCL2
15	NF-kappaB Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ Apoptosis Pathway ⁷⁰	12.46	TP53 PIK3CA EGFR CTNNB1 BCL2
16	Death Receptor Signaling ⁶⁷ Show member pathways Apoptosis and survival Apoptotic TNF-family pathways ²² Apoptosis Signaling Pathway ⁶⁵ SARS-CoV-1-mediated effects on programmed cell death ⁶⁶ TNF Signaling ⁶⁷	12.39	TP53 CDKN1A BCL2 BAK1
17	Focal adhesion ⁷⁴	12.31	PIK3CA EGFR CTNNB1 BCL2
18	Breast cancer pathway ⁷⁴ Show member pathways Embryonic stem cell pluripotency pathways ⁷⁴	12.29	TP53 PIK3CA NOTCH2 NOTCH1 EGFR CTNNB1
19	Intrinsic Pathway for Apoptosis ⁶⁶ Show member pathways Activation of BAD and translocation to mitochondria ⁶⁶ Activation of BH3-only proteins ⁶⁶ Activation of BIM and translocation to mitochondria ⁶⁶ Activation of BMF and translocation to mitochondria ⁶⁶ Activation of NOXA and translocation to mitochondria ⁶⁶ Activation of PUMA and translocation to mitochondria ⁶⁶ Activation, myristolyation of BID and translocation to mitochondria ⁶⁶ Apoptotic factor-mediated response ⁶⁶ BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members ⁶⁶ Cytochrome c-mediated apoptotic response ⁶⁶ Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function ⁶⁶ Release of apoptotic factors from the mitochondria ⁶⁶ SMAC, XIAP-regulated apoptotic response ⁶⁶	12.27	TP53 GZMB BCL2 BAK1
20	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.27	TP53 PIK3CA MSH2 MLH1 EGFR CTNNB1
21	NOTCH2 Activation and Transmission of Signal to the Nucleus ⁶⁶ Show member pathways Activated NOTCH1 Transmits Signal to the Nucleus ⁶⁶ Constitutive Signaling by NOTCH1 HD Domain Mutants ⁶⁶ Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant ⁶⁶ Noncanonical activation of NOTCH3 ⁶⁶ NOTCH2 intracellular domain regulates transcription ⁶⁶ NOTCH3 Activation and Transmission of Signal to the Nucleus ⁶⁶ Signaling by NOTCH1 HD Domain Mutants in Cancer ⁶⁶ Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant ⁶⁶ Signaling by NOTCH2 ⁶⁶	12.25	NOTCH2 NOTCH1 GZMB EGFR
22	MAPK Signaling: Mitogens ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	12.24	BCL2 CDKN1A EGFR PIK3CA TP53
23	Transcription Androgen Receptor nuclear signaling ²² Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²²	12.15	PIK3CA EGFR CTNNB1 CDKN1A
24	Epithelial to mesenchymal transition in colorectal cancer ⁷⁴	12.14	TP53 PIK3CA NOTCH2 NOTCH1 CTNNB1 CDH1
25	Colorectal Cancer Metastasis ⁶⁴	12.13	CDH1 CDKN1A CTNNB1 EGFR MLH1 MSH2
26	Presenilin-Mediated Signaling ⁶⁴	12.09	NOTCH2 NOTCH1 CTNNB1 CDH1 BCL2
27	Integrated breast cancer pathway ⁷⁴	12.04	TP53 MSH2 EGFR CTNNB1 CDH1 BCL2
28	Gastrin signaling pathway ⁷⁴	11.96	CDH1 CDKN1A CTNNB1 EGFR PIK3CA
29	Neural crest differentiation ⁷⁴	11.95	NOTCH2 NOTCH1 CTNNB1 CDH1
30	Notch Signaling Pathways ⁶⁵	11.94	BCL2 CTNNB1 NOTCH1 NOTCH2
31	p53 transcriptional gene network ⁷⁴	11.91	NOTCH1 MSH2 MLH1 CDKN1A
32	Overlap between signal transduction pathways contributing to LMNA laminopathies ⁷⁴ Show member pathways Influence of laminopathies on Wnt signaling ⁷⁴	11.89	NOTCH1 CTNNB1 CDKN1A
33	DNA damage response (only ATM dependent) ⁷⁴	11.89	TP53 PIK3CA CTNNB1 CDKN1A BCL2 BAK1
34	Corticotropin-releasing hormone signaling pathway ⁷⁴	11.88	KRT14 IVL CTNNB1 BCL2
35	Small cell lung cancer ⁷⁴	11.87	TP53 PIK3CA CDKN1A BCL2 BAK1
36	Thyroid hormones production and peripheral downstream signaling effects ⁷⁴	11.83	TP53 PIK3CA NOTCH1 CTNNB1
37	DNA IR-damage and cellular response via ATR ⁷⁴	11.82	TP53 MSH2 MLH1
38	Direct p53 effectors ⁶¹	11.81	BAK1 BCL2 CDKN1A EGFR MLH1 MSH2
39	Burn wound healing ⁷⁴	11.78	TP53 FLG BCL2
40	Glucocorticoid receptor regulatory network ⁶¹	11.78	TP53 KRT17 KRT14 CDKN1A
41	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ⁶¹	11.76	PIK3CA CTNNB1 CDH1
42	Transcription_P53 signaling pathway ²²	11.74	TP53 CTNNB1 CDKN1A BCL2
43	Primary focal segmental glomerulosclerosis (FSGS) ⁷⁴	11.73	NOTCH1 MKI67 CTNNB1 CDKN1A
44	Physico-chemical features and toxicity-associated pathways ⁷⁴	11.71	EGFR CTNNB1 CDKN1A
45	Pathways affected in adenoid cystic carcinoma ⁷⁴	11.69	TP53 PIK3CA NOTCH1
46	Osteoblast differentiation and related diseases ⁷⁴	11.67	PIK3CA NOTCH2 NOTCH1 CTNNB1
47	FGF signaling pathway ⁶¹	11.62	CDH1 GZMB PIK3CA
48	Notch signaling pathway ⁶¹	11.62	CDKN1A NOTCH1 NOTCH2
49	Posttranslational regulation of adherens junction stability and dissassembly ⁶¹	11.56	EGFR CTNNB1 CDH1
50	Busulfan Pathway, Pharmacodynamics ⁶⁰ Show member pathways Catalytic cycle of mammalian flavin-containing monooxygenases (FMOs) ⁷⁴ Defective FMO3 causes TMAU ⁶⁶ FMO oxidises nucleophiles ⁶⁶	11.53	BCL2 MLH1 MSH2

Sources

GO Terms for Keratoacanthoma

Cellular components related to Keratoacanthoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell periphery	GO:0071944	9.35	NOTCH1 KRT17 KRT14 CTNNB1
2	cornified envelope	GO:0001533	9.32	KRT17 KRT14 KRT10 IVL FLG

Biological processes related to Keratoacanthoma according to GeneCards Suite gene sharing:

(show all 32)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell population proliferation	GO:0008285	10.33	TP53 NOTCH1 CTNNB1 CDKN1A BCL2 BAK1
2	response to xenobiotic stimulus	GO:0009410	10.26	TP53 CTNNB1 CDH1 BCL2 BAK1
3	in utero embryonic development	GO:0001701	10.25	TP53 NOTCH2 NOTCH1 MSH2 CTNNB1
4	regulation of cell cycle	GO:0051726	10.24	TP53 MSH2 CDKN1A BCL2 BAK1
5	positive regulation of apoptotic process	GO:0043065	10.22	BAK1 BCL2 CTNNB1 NOTCH1 NOTCH2 TP53
6	T cell differentiation in thymus	GO:0033077	10.11	BCL2 CTNNB1 TP53
7	epithelial cell differentiation	GO:0030855	10.11	KRT17 KRT15 KRT14 KRT10
8	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO:0070059	10.04	BAK1 BCL2 TP53
9	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO:0042771	10.03	TP53 MSH2 CDKN1A
10	peptide cross-linking	GO:0018149	10.01	KRT10 IVL FLG
11	response to gamma radiation	GO:0010332	10	BAK1 BCL2 TP53
12	release of cytochrome c from mitochondria	GO:0001836	9.97	TP53 BCL2 BAK1
13	epidermis development	GO:0008544	9.97	EGFR KRT10 KRT14 KRT15 NOTCH1
14	negative regulation of gene expression	GO:0010629	9.97	BAK1 CDKN1A CTNNB1 NOTCH1 NOTCH2 PIK3CA
15	mesenchymal cell development	GO:0014031	9.95	NOTCH1 BCL2
16	atrioventricular node development	GO:0003162	9.95	NOTCH2 NOTCH1
17	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.95	MSH2 MLH1 BCL2 BAK1
18	cellular response to indole-3-methanol	GO:0071681	9.93	CTNNB1 CDH1
19	negative regulation of anoikis	GO:2000811	9.93	PIK3CA NOTCH1 BCL2
20	B cell lineage commitment	GO:0002326	9.92	TP53 BCL2
21	positive regulation of isotype switching to IgA isotypes	GO:0048298	9.91	MLH1 MSH2
22	cellular response to tumor cell	GO:0071228	9.88	NOTCH2 NOTCH1
23	hair follicle morphogenesis	GO:0031069	9.86	NOTCH1 KRT17 CTNNB1 BCL2
24	T cell lineage commitment	GO:0002360	9.82	TP53 BCL2
25	response to UV-B	GO:0010224	9.8	MSH2 IVL BCL2
26	signal transduction by p53 class mediator	GO:0072331	9.77	CDKN1A TP53
27	somatic recombination of immunoglobulin gene segments	GO:0016447	9.75	MSH2 MLH1
28	positive regulation of miRNA maturation	GO:1903800	9.65	TP53 EGFR
29	keratinocyte differentiation	GO:0030216	9.65	NOTCH1 KRT14 KRT10 IVL FLG
30	leukocyte homeostasis	GO:0001776	9.62	BCL2 BAK1
31	somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	9.61	MSH2 MLH1
32	cell population proliferation	GO:0008283	9.23	TP53 NOTCH2 NOTCH1 MKI67 EGFR CTNNB1

Molecular functions related to Keratoacanthoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatin binding	GO:0003682	10.06	TP53 NOTCH1 MSH2 MLH1 EGFR CTNNB1
2	protein phosphatase binding	GO:0019903	9.7	BCL2 CTNNB1 EGFR TP53
3	guanine/thymine mispair binding	GO:0032137	9.56	MSH2 MLH1
4	enzyme binding	GO:0019899	9.47	TP53 NOTCH2 NOTCH1 MSH2 MLH1 EGFR
5	structural molecule activity	GO:0005198	9.43	KRT17 KRT15 KRT14 KRT10 FLG

Sources

Sources for Keratoacanthoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: KRT005 MIFTS: 52	Keratoacanthoma Categories: Cancer diseases, Genetic diseases, Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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