KPC
MCID: KRT020
MIFTS: 29

Keratoconus Posticus Circumscriptus (KPC)

Categories: Rare diseases

Aliases & Classifications for Keratoconus Posticus Circumscriptus

MalaCards integrated aliases for Keratoconus Posticus Circumscriptus:

Name: Keratoconus Posticus Circumscriptus 58 77 54 74
Kpc 58 54

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive


HPO:

33
keratoconus posticus circumscriptus:
Inheritance autosomal recessive inheritance


Classifications:



Summaries for Keratoconus Posticus Circumscriptus

MalaCards based summary : Keratoconus Posticus Circumscriptus, also known as kpc, is related to craniosynostosis 1 and keratoconus. Affiliated tissues include testes, eye and colon, and related phenotypes are hypertelorism and short neck

Wikipedia : 77 Keratoconus (KC) is a disorder of the eye which results in progressive thinning of the cornea. This may... more...

Description from OMIM: 244600

Related Diseases for Keratoconus Posticus Circumscriptus

Diseases related to Keratoconus Posticus Circumscriptus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 craniosynostosis 1 11.3
2 keratoconus 10.9
3 cerebrotendinous xanthomatosis 10.5
4 cataract 10.4
5 cleft lip 10.4
6 cleft lip/palate 10.4
7 pancreatic cancer 10.2
8 tetralogy of fallot 10.2
9 multiple sclerosis 10.1
10 pneumonia 10.1
11 aplasia cutis congenita, nonsyndromic 9.9
12 blood group, colton system 9.9
13 cerebellar ataxia, neuropathy, and vestibular areflexia syndrome 9.9
14 brain injury 9.9
15 diabetes mellitus 9.9
16 hematopoietic stem cell transplantation 9.9
17 pancreatic ductal adenocarcinoma 9.9
18 spinal cord injury 9.9
19 traumatic brain injury 9.9
20 osteomyelitis 9.9
21 pyelonephritis 9.9
22 adenocarcinoma 9.9
23 cellulitis 9.9
24 peritonitis 9.9
25 pyomyositis 9.9
26 meningitis 9.9

Graphical network of the top 20 diseases related to Keratoconus Posticus Circumscriptus:



Diseases related to Keratoconus Posticus Circumscriptus

Symptoms & Phenotypes for Keratoconus Posticus Circumscriptus

Human phenotypes related to Keratoconus Posticus Circumscriptus:

33 (show all 15)
# Description HPO Frequency HPO Source Accession
1 hypertelorism 33 HP:0000316
2 short neck 33 HP:0000470
3 global developmental delay 33 HP:0001263
4 cleft palate 33 HP:0000175
5 growth delay 33 HP:0001510
6 webbed neck 33 HP:0000465
7 clinodactyly of the 5th finger 33 HP:0004209
8 brachydactyly 33 HP:0001156
9 vesicoureteral reflux 33 HP:0000076
10 recurrent urinary tract infections 33 HP:0000010
11 cleft upper lip 33 HP:0000204
12 keratoconus 33 HP:0000563
13 abnormal vertebral segmentation and fusion 33 HP:0005640
14 limited elbow extension and supination 33 HP:0005852
15 central posterior corneal opacity 33 HP:0008511

Symptoms via clinical synopsis from OMIM:

58
H E E N T:
hypertelorism
cleft lip/palate
corneal nebulae
posterior corneal depression
central posterior corneal opacities

Growth:
retarded growth

G U:
frequent urinary tract infections
ureteric reflux

Skel:
webbed neck
brachydactyly
abnormal vertebral segmentation and fusion
limited elbow extension and supination
fifth finger clinodactyly
more
Neuro:
retarded mental development

Clinical features from OMIM:

244600

Drugs & Therapeutics for Keratoconus Posticus Circumscriptus

Search Clinical Trials , NIH Clinical Center for Keratoconus Posticus Circumscriptus

Genetic Tests for Keratoconus Posticus Circumscriptus

Anatomical Context for Keratoconus Posticus Circumscriptus

MalaCards organs/tissues related to Keratoconus Posticus Circumscriptus:

42
Testes, Eye, Colon, Brain, Spinal Cord, Liver, Kidney

Publications for Keratoconus Posticus Circumscriptus

Articles related to Keratoconus Posticus Circumscriptus:

(show top 50) (show all 811)
# Title Authors Year
1
High prevalence of KPC-2-producing hypervirulent Klebsiella pneumoniae causing meningitis in Eastern China. ( 30936727 )
2019
2
Mouse-Derived Allografts: A Complementary Model to the KPC Mice on Researching Pancreatic Cancer In Vivo. ( 31011408 )
2019
3
Co-carriage of distinct blaKPC-2 and blaOXA-48 plasmids in a single ST11 carbapenem-resistant Klebsiella pneumoniae isolate. ( 30962338 )
2019
4
Whole genome assembly and functional portrait of hypervirulent extensively drug-resistant NDM-1 and KPC-2 co-producing Klebsiella pneumoniae of capsular serotype K2 and ST86. ( 30843067 )
2019
5
Laboratory validation of a KPC-producing strain identification method based on the detection of a specific 11,109 Da peak via Maldi-Tof-Vitek MS in an endemic area. ( 31034082 )
2019
6
MALDI-TOF MS based procedure to detect KPC-2 directly from positive blood culture bottles and colonies. ( 30849422 )
2019
7
Comparative analysis of KPC-2-encoding chimera plasmids with multi-replicon IncR:IncpA1763-KPC:IncN1 or IncFIIpHN7A8:IncpA1763-KPC:IncN1. ( 30774396 )
2019
8
Report of a KPC-producing Pseudomonas aeruginosa isolate in Canada. ( 30783655 )
2019
9
Rapid identification of NDM-, KPC-, IMP-, VIM- and OXA-48-like carbapenemase-producing Enterobacteriales from blood cultures by a multiplex lateral flow immunoassay. ( 30789220 )
2019
10
Structure of the capsular polysaccharide of the KPC-2-producing Klebsiella pneumoniae strain KK207-2 and assignment of the glycosyltransferases functions. ( 30802520 )
2019
11
Clearance of carbapenemase-producing Enterobacteriaceae (CPE) carriage: a comparative study of NDM-1 and KPC CPE - author's reply. ( 30818003 )
2019
12
Comparative Analysis of blaKPC Expression in Tn4401 Transposons and the Tn3-Tn4401 Chimera. ( 30833426 )
2019
13
In Vitro Effectiveness of Meropenem and Cefmetazole Combination Treatment Against KPC-2-Producing Enterobacteriaceae. ( 30835635 )
2019
14
Plasmid-Mediated Transmission of KPC-2 Carbapenemase in Enterobacteriaceae in Critically Ill Patients. ( 30837980 )
2019
15
Interplay among IncA and blaKPC-Carrying Plasmids in Citrobacter freundii. ( 30858205 )
2019
16
Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. ( 30904754 )
2019
17
Novel patterns in the molecular epidemiology of KPC-producing Klebsiella pneumoniae in Tucuman, Argentina. ( 30910742 )
2019
18
Genomic characterization of a KPC-23-producing Klebsiella pneumoniae ST258 clinical isolate resistant to ceftazidime-avibactam. ( 30928562 )
2019
19
Disruption of KPC-producing Klebsiella pneumoniae membrane via induction of oxidative stress by cinnamon bark (Cinnamomum verum J. Presl) essential oil. ( 30939149 )
2019
20
A Phage-Like Plasmid Carrying blaKPC-2 Gene in Carbapenem-Resistant Pseudomonas aeruginosa. ( 30949157 )
2019
21
First clinical case of KPC-3-producing Klebsiella michiganensis in Europe. ( 30949345 )
2019
22
First evidence of KPC-producing ST258 Klebsiella pneumoniae in river water. ( 30959088 )
2019
23
Report on two hypervirulent Klebsiella pneumoniae producing a blaKPC-2 carbapenemase from a Canadian patient. ( 30988151 )
2019
24
First Report of KPC-2 and KPC-3-Producing Enterobacteriaceae in Wild Birds in Africa. ( 31055618 )
2019
25
Molecular Detection of Class 1 Integron-Associated Gene Cassettes in KPC-2-Producing Klebsiella pneumoniae Clones by Whole-Genome Sequencing. ( 31074706 )
2019
26
Use of a cohorting-unit and systematic surveillance cultures to control a Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae outbreak. ( 31084655 )
2019
27
Identification of L169P mutation in the omega loop of KPC-3 after a short course of ceftazidime/avibactam. ( 31086956 )
2019
28
Equal, but different: Fluctuant biofilm formation and its impact on polymyxin B susceptibility among a clonal spreading of KPC-2-producing Klebsiella pneumoniae isolates. ( 31106716 )
2019
29
Potential KPC-2 carbapenemase reservoir of environmental Aeromonas hydrophila and Aeromonas caviae isolates from the effluent of an urban wastewater treatment plant in Japan. ( 31106978 )
2019
30
In vitro evaluation of meropenem-vaborbactam against clinical CRE isolates at a tertiary care center with low KPC-mediated carbapenem resistance. ( 30344065 )
2019
31
First Report of Whole-Genome Sequence of Colistin-Resistant Klebsiella quasipneumoniae subsp. similipneumoniae Producing KPC-9 in India. ( 30427763 )
2019
32
Rapid detection of OXA-48-like, KPC, NDM, and VIM carbapenemases in Enterobacterales by a new multiplex immunochromatographic test. ( 30448931 )
2019
33
Killing activity of meropenem in combination with amikacin against VIM- or KPC-producing Enterobacteriaceae that are susceptible, intermediate, or resistant to amikacin. ( 30514595 )
2019
34
An IncR Plasmid Harbored by a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Strain Possesses Five Tandem Repeats of the blaKPC-2::NTEKPC-Id Fragment. ( 30530604 )
2019
35
Small IncQ1 and Col-like Plasmids Harboring blaKPC-2 and non-Tn4401 Elements (NTEKPC-IId) in High-Risk Lineages of Klebsiella pneumoniae CG258. ( 30602517 )
2019
36
Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae ST258 isolated from a Japanese patient without a history of foreign travel - a new public health concern in Japan: a case report. ( 30616536 )
2019
37
Effects of KPC Variant and Porin Genotype on the In Vitro Activity of Meropenem-Vaborbactam against Carbapenem-Resistant Enterobacteriaceae. ( 30617090 )
2019
38
Re: 'Clearance of carbapenemase-producing Enterobacteriaceae (CPE) carriage: a comparative study of NDM-1 and KPC CPE' by Lim et al. (2018). ( 30630067 )
2019
39
In vitro synergistic activity of meropenem/vaborbactam in combination with ceftazidime/avibactam against KPC-producing Klebsiella pneumoniae. ( 30649310 )
2019
40
Evaluation of a novel immunochromatographic lateral flow assay for rapid detection of OXA-48, NDM, KPC and VIM carbapenemases in multidrug-resistant Enterobacteriaceae. ( 30663953 )
2019
41
Antagonistic effect between tigecycline and meropenem: successful management of KPC-producing Klebsiella pneumoniae infection. ( 30734249 )
2019
42
Evaluation of the RESIST-4 K-SeT assay, a multiplex immunochromatographic assay for the rapid detection of OXA-48-like, KPC, VIM and NDM carbapenemases. ( 30753488 )
2019
43
Ceftazidime/avibactam resistance associated with L169P mutation in the omega loop of KPC-2. ( 30753572 )
2019
44
Immunophenotyping of Orthotopic Homograft (Syngeneic) of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry. ( 30371656 )
2018
45
Treatment of a Klebsiella pneumoniae KPC cellulitis and gut decolonization with ceftazidime/avibactam in a migrant from Libya. ( 29336224 )
2018
46
Colistin-resistant Klebsiella pneumoniae co-harboring KPC and MCR-1 in a Hematopoietic Stem Cell Transplantation Unit. ( 30504905 )
2018
47
Ceftazidime/Avibactam for Refractory Bacteremia, Vertebral Diskitis/Osteomyelitis with Pre-Vertebral Abscess and Bilateral Psoas Pyomyositis Secondary to Klebsiella Pneumoniae Carbapenemase-Producing Bacteria (KPC). ( 29905925 )
2018
48
Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer. ( 30306263 )
2018
49
Post-operative peritonitis due to a KPC-producing Klebsiella pneumoniae: the canvas of antibiotic resistance. ( 30374375 )
2018
50
Activity of fosfomycin alone or combined with temocillin in vitro and in a murine model of peritonitis due to KPC-3- or OXA-48-producing Escherichia coli. ( 30085154 )
2018

Variations for Keratoconus Posticus Circumscriptus

Expression for Keratoconus Posticus Circumscriptus

Search GEO for disease gene expression data for Keratoconus Posticus Circumscriptus.

Pathways for Keratoconus Posticus Circumscriptus

GO Terms for Keratoconus Posticus Circumscriptus

Sources for Keratoconus Posticus Circumscriptus

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
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35 ICD10 via Orphanet
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46 MESH via Orphanet
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50 NCI
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59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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