MCID: KRT063
MIFTS: 42

Keratocystic Odontogenic Tumor

Categories: Oral diseases, Rare diseases

Aliases & Classifications for Keratocystic Odontogenic Tumor

MalaCards integrated aliases for Keratocystic Odontogenic Tumor:

Name: Keratocystic Odontogenic Tumor 59 73
Tumor, Keratocystic Odontogenic 40
Odontogenic Keratocystoma 59
Ktoc 59

Characteristics:

Orphanet epidemiological data:

59
keratocystic odontogenic tumor
Inheritance: Not applicable;

Classifications:

Orphanet: 59  
Rare odontological diseases


External Ids:

Orphanet 59 ORPHA447777
ICD10 via Orphanet 34 D16.4
UMLS 73 C1708604

Summaries for Keratocystic Odontogenic Tumor

MalaCards based summary : Keratocystic Odontogenic Tumor, also known as tumor, keratocystic odontogenic, is related to basal cell nevus syndrome and ameloblastoma, and has symptoms including pain An important gene associated with Keratocystic Odontogenic Tumor is PTCH1 (Patched 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and G-Beta Gamma Signaling. Affiliated tissues include bone and endothelial, and related phenotypes are digestive/alimentary and cardiovascular system

Related Diseases for Keratocystic Odontogenic Tumor

Diseases related to Keratocystic Odontogenic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 basal cell nevus syndrome 32.3 GLI1 PTCH1 SHH SMO SUFU
2 ameloblastoma 31.4 GLI1 PTCH1 SMO TNFSF11
3 basal cell carcinoma 29.6 BCL2 GLI1 MKI67 PTCH1 SHH SMO
4 squamous cell carcinoma 29.3 CCND1 MKI67 PTCH1 PTGS2 PTHLH TP53
5 brain ependymoma 10.9 MKI67 TP53
6 heart tumor 10.9 BCL2 PTCH1
7 calcifying epithelial odontogenic tumor 10.9 PTCH1 TP53
8 clear cell cystadenofibroma 10.8 CALB2 TP53
9 protoplasmic astrocytoma 10.8 PTGS2 TP53
10 basal cell carcinoma, multiple 10.8 PTCH1 SMO
11 soft tissue sarcoma 10.7 BCL2 MKI67 TP53
12 vulvar intraepithelial neoplasia 10.7 BIRC5 TP53
13 cervical carcinosarcoma 10.7 BCL2 BIRC5 TP53
14 hemophilic arthropathy 10.6 PTGS2 TNFSF11
15 septopreoptic holoprosencephaly 10.6 PTCH1 SHH
16 bladder transitional cell papilloma 10.6 BIRC5 TP53
17 midline interhemispheric variant of holoprosencephaly 10.6 PTCH1 SHH
18 cerebellar liponeurocytoma 10.6 PTCH1 SUFU TP53
19 ovarian serous cystadenocarcinoma 10.6 BCL2 BIRC5 TP53
20 cerebellum cancer 10.6 SHH SUFU TP53
21 microform holoprosencephaly 10.6 PTCH1 SHH SUFU
22 gastric tubular adenocarcinoma 10.6 GLI1 PTGS2 SHH
23 basal cell carcinoma 1 10.6
24 spitz nevus 10.5 MKI67 TP53
25 nodular medulloblastoma 10.5 GLI1 PTCH1 SUFU
26 suppressor of tumorigenicity 3 10.5 BCL2 FHIT TP53
27 lymphoma, small cleaved-cell, diffuse 10.4 BCL2 CCND1
28 tooth ankylosis 10.4 PTHLH TNFSF11
29 villonodular synovitis 10.4 MMP9 TNFSF11
30 pigmented villonodular synovitis 10.4 MMP9 TNFSF11 TP53
31 barrett's adenocarcinoma 10.4 FHIT PTGS2 TP53
32 central nervous system tuberculosis 10.3 GLI1 MMP9 SHH
33 differentiated thyroid carcinoma 10.3 BCL2 FHIT TP53
34 cervical intraepithelial neoplasia 10.3 BIRC5 FHIT MKI67
35 brain cancer 10.3 GLI1 PTCH1 SHH TP53
36 meningioma, familial 10.3 MKI67 PTCH1 SUFU TP53
37 oral leukoplakia 10.3 CCND1 MKI67 TP53
38 endotheliitis 10.2
39 skin melanoma 10.2 MKI67 MMP9 PTGS2 TP53
40 gastrointestinal system benign neoplasm 10.2 CCND1 PTGS2 TP53
41 intestinal benign neoplasm 10.2 CCND1 PTGS2 TP53
42 inflammatory myofibroblastic tumor 10.2 CCND1 MKI67 TP53
43 bowenoid papulosis 10.2 CCND1 PTGS2
44 ductal carcinoma in situ 10.1 CCND1 PTGS2 TP53
45 integumentary system cancer 10.1 GLI1 PTCH1 PTGS2 SHH TP53
46 bile duct carcinoma 10.1 CCND1 PTGS2 TP53
47 hidradenocarcinoma 10.0 BCL2 CCND1 MKI67 TP53
48 familial adenomatous polyposis 10.0 CCND1 PTGS2 TP53
49 adult medulloblastoma 10.0 GLI1 PTCH1 SHH SUFU TP53
50 infratentorial cancer 10.0 GLI1 PTCH1 SHH SUFU TP53

Graphical network of the top 20 diseases related to Keratocystic Odontogenic Tumor:



Diseases related to Keratocystic Odontogenic Tumor

Symptoms & Phenotypes for Keratocystic Odontogenic Tumor

UMLS symptoms related to Keratocystic Odontogenic Tumor:


pain

MGI Mouse Phenotypes related to Keratocystic Odontogenic Tumor:

46 (show all 24)
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.44 BCL2 CCND1 CTNNBIP1 FHIT GLI1 MMP9
2 cardiovascular system MP:0005385 10.42 SUFU TP53 BCL2 CCND1 CTNNBIP1 HPSE
3 cellular MP:0005384 10.42 CTNNBIP1 GLI1 HPSE MMP9 PTCH1 PTGS2
4 growth/size/body region MP:0005378 10.41 BCL2 TNFSF11 TP53 CCND1 CTNNBIP1 GLI1
5 behavior/neurological MP:0005386 10.4 MMP9 PDPN PTCH1 PTGS2 PTHLH SHH
6 hematopoietic system MP:0005397 10.4 BCL2 BIRC5 CCND1 CTNNBIP1 FHIT HPSE
7 mortality/aging MP:0010768 10.4 BCL2 BIRC5 SUFU TNFSF11 TP53 CCND1
8 homeostasis/metabolism MP:0005376 10.39 BCL2 BIRC5 CCND1 FHIT MMP9 PDPN
9 immune system MP:0005387 10.38 BCL2 BIRC5 CCND1 FHIT HPSE MMP9
10 craniofacial MP:0005382 10.34 BCL2 CCND1 CTNNBIP1 GLI1 PTCH1 PTHLH
11 integument MP:0010771 10.34 BCL2 CCND1 FHIT HPSE MMP9 PDPN
12 endocrine/exocrine gland MP:0005379 10.32 BCL2 BIRC5 CCND1 GLI1 HPSE PTCH1
13 embryo MP:0005380 10.28 TP53 BCL2 BIRC5 CTNNBIP1 GLI1 PTCH1
14 nervous system MP:0003631 10.25 BCL2 CALB2 CCND1 CTNNBIP1 GLI1 MMP9
15 limbs/digits/tail MP:0005371 10.21 SUFU TNFSF11 TP53 GLI1 HPSE MMP9
16 neoplasm MP:0002006 10.2 TP53 BCL2 CCND1 FHIT GLI1 MMP9
17 normal MP:0002873 10.15 BIRC5 CALB2 CCND1 GLI1 MKI67 PTCH1
18 muscle MP:0005369 10.13 BCL2 MMP9 PDPN PTCH1 PTGS2 SHH
19 no phenotypic analysis MP:0003012 10.01 GLI1 MKI67 PTCH1 PTGS2 SHH SUFU
20 respiratory system MP:0005388 10 SMO SUFU TNFSF11 TP53 CCND1 CTNNBIP1
21 renal/urinary system MP:0005367 9.97 PTHLH SHH TP53 BCL2 CTNNBIP1 GLI1
22 reproductive system MP:0005389 9.96 BCL2 CCND1 GLI1 MMP9 PTCH1 PTGS2
23 skeleton MP:0005390 9.77 CCND1 CTNNBIP1 HPSE MMP9 PDPN PTCH1
24 vision/eye MP:0005391 9.4 MMP9 PTCH1 PTGS2 PTHLH SHH SMO

Drugs & Therapeutics for Keratocystic Odontogenic Tumor

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2, Single-center, Single-arm, Open Label Trial of Vismodegib in Patients With Keratocystic Odontogenic Tumors Active, not recruiting NCT02366312 Phase 2 vismodegib

Search NIH Clinical Center for Keratocystic Odontogenic Tumor

Genetic Tests for Keratocystic Odontogenic Tumor

Anatomical Context for Keratocystic Odontogenic Tumor

MalaCards organs/tissues related to Keratocystic Odontogenic Tumor:

41
Bone, Endothelial

Publications for Keratocystic Odontogenic Tumor

Articles related to Keratocystic Odontogenic Tumor:

(show top 50) (show all 104)
# Title Authors Year
1
Comparison of osteoclastogenesis and local invasiveness of ameloblastoma and keratocystic odontogenic tumor. ( 29657523 )
2018
2
A Case of an Extensive Keratocystic Odontogenic Tumor in the Mandible Reconstructed with a Custom-Made Total Joint Prosthesis. ( 29892328 )
2018
3
Corrigendum to "malignant transformation of keratocystic odontogenic tumor: Two case reports" [American journal of otolaryngology 34 (2013) 357-361]. ( 28341089 )
2017
4
Recurrent keratocystic odontogenic tumor of right maxillary sinus involving the right infraorbital rim. ( 28761280 )
2017
5
What surgical treatment has the lowest recurrence rate following the management of keratocystic odontogenic tumor?: A large systematic review and meta-analysis. ( 27955959 )
2017
6
Squamous cell carcinoma arising from keratocystic odontogenic tumor. ( 28479710 )
2017
7
Computer-aided diagnosis of periapical cyst and keratocystic odontogenic tumor on cone beam computed tomography. ( 28688493 )
2017
8
Expression of YAP/TAZ in Keratocystic Odontogenic Tumors and Its Possible Association with Proliferative Behavior. ( 28512636 )
2017
9
Conservative Treatment of Multiple Keratocystic Odontogenic Tumors in a Young Patient with Nevoid Basal Cell Carcinoma Syndrome by Decompression: A 7-year Follow-up Study. ( 28650783 )
2017
10
Assessing alpha-tocopherol levels in patients with keratocystic odontogenic tumor: A cross-sectional study. ( 28611319 )
2017
11
Molecular analysis of keratocystic odontogenic tumor cell lines derived from sporadic and basal cell nevus syndrome patients. ( 29039452 )
2017
12
Squamous cell carcinoma arising from a keratocystic odontogenic tumor: a case report. ( 29191248 )
2017
13
Keratocystic Odontogenic Tumor Involving the Orbital Apex. ( 28099232 )
2017
14
Using Carnoy's Solution in Treatment of Keratocystic Odontogenic Tumor. ( 28713736 )
2017
15
Maxillary peripheral keratocystic odontogenic tumor. A clinical case report. ( 28149484 )
2017
16
Comparative immunohistochemical study of Bcl-X in ameloblastoma, keratocystic odontogenic tumor and adenomatoid odontogenic tumor. ( 28479687 )
2017
17
Recurrent Keratocystic Odontogenic Tumor After Effective Decompression. ( 27391520 )
2016
18
FAK is overexpressed in keratocystic odontogenic tumor: a preliminary study. ( 27935113 )
2016
19
Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma. ( 27076824 )
2016
20
Radiological challenges in distinguishing keratocystic odontogenic tumor from ameloblastoma: an extraordinary occurrence in the same patient. ( 27038821 )
2016
21
Immunohistochemical expression of vascular endothelial growth factor in keratocystic odontogenic tumor, dentigerous cyst, and radicular cyst: A comparative study. ( 27134450 )
2016
22
CD166 expression in dentigerous cyst, keratocystic odontogenic tumor and ameloblastoma. ( 27398171 )
2016
23
Primary intraosseous squamous cell carcinoma in pre-existing keratocystic odontogenic tumor: A case report and literature review. ( 26893858 )
2016
24
The Possible Role of Mast Cells in the Odontogenic Cyst's Pathogenesis: A Comparative Study between Dentigerous Cyst and Keratocystic Odontogenic Tumor. ( 27022501 )
2016
25
Role of carnoy's solution in the treatment of keratocystic odontogenic tumor: A systematic review. ( 27475699 )
2016
26
Transcriptome Variability in Keratocystic Odontogenic Tumor Suggests Distinct Molecular Subtypes. ( 27066764 )
2016
27
Keratocystic odontogenic tumor with ossification and calcification: A case report with unusual histological findings. ( 27723645 )
2016
28
Big Keratocystic Odontogenic Tumor of the Mandible: A Case Report. ( 28446856 )
2016
29
Orthokeratinized Odontogenic Cyst with an Associated Keratocystic Odontogenic Tumor Component and Ghost Cell Keratinization and Calcifications in a Patient with Gardner Syndrome. ( 27501963 )
2016
30
The Clinical Features and Expression of bcl-2, Cyclin D1, p53, and Proliferating Cell Nuclear Antigen in Syndromic and Nonsyndromic Keratocystic Odontogenic Tumor. ( 27391504 )
2016
31
Topical 5-Fluorouracil is a Novel Targeted Therapy for the Keratocystic Odontogenic Tumor. ( 27789270 )
2016
32
Giant keratocystic odontogenic tumor: a challenging diagnosis. ( 27818958 )
2016
33
Does the Excision of Overlying Oral Mucosa Reduce the Recurrence Rate in the Treatment of the Keratocystic Odontogenic Tumor? A Systematic Review and Meta-Analysis. ( 27134155 )
2016
34
Need to reclassify keratocystic odontogenic tumor into cyst and neoplasm. ( 28163493 )
2016
35
Regarding "Significantly Decreased Recurrence Rates in Keratocystic Odontogenic Tumor With Simple Enucleation and Curettage Using Carnoy's Versus Modified Carnoy's Solution". ( 26968801 )
2016
36
The effect of ameloblastoma and keratocystic odontogenic tumor on the displacement pattern of inferior alveolar canal in CBCT examinations. ( 27651881 )
2016
37
Bioinformatics Analysis Reveals Genes Involved in the Pathogenesis of Ameloblastoma and Keratocystic Odontogenic Tumor. ( 28357197 )
2016
38
Keratocystic odontogenic tumor overexpresses invadopodia-related proteins, suggesting invadopodia formation. ( 27554376 )
2016
39
Keratocystic odontogenic tumor: role of cone beam computed tomography and magnetic resonance imaging. ( 26742165 )
2016
40
Keratocystic odontogenic tumor: A biopsy service's experience with 104 solitary, multiple and recurrent lesions. ( 27475695 )
2016
41
Re: "Significantly Decreased Recurrence Rates in Keratocystic Odontogenic Tumor With Simple Enucleation and Curettage Using Carnoy's Versus Modified Carnoy's Solution". ( 26968803 )
2016
42
Keratocystic odontogenic tumor. ( 28273221 )
2016
43
The evaluation of Ki67, p53, MCM3 and PCNA immunoexpressions at the level of the dental follicle of impacted teeth, dentigerous cysts and keratocystic odontogenic tumors. ( 27516012 )
2016
44
Reconstruction of extensive jaw defects induced by keratocystic odontogenic tumor via patient-customized devices. ( 26501043 )
2015
45
Expression of Bcl-2 and epithelial growth factor receptor proteins in keratocystic odontogenic tumor in comparison with dentigerous cyst and ameloblastoma. ( 26288624 )
2015
46
Differential expression of TLR3 and TLR4 in keratocystic odontogenic tumor (KCOT): A comparative immunohistochemical study in primary, recurrent, and nevoid basal cell carcinoma syndrome (NBCCS)--associated lesions. ( 25976039 )
2015
47
Keratocystic odontogenic tumor arising at the mandibular ramus with an impacted tooth: a case report and mimic lesions. ( 26715100 )
2015
48
P53 polymorphism at codon 72 is associated with keratocystic odontogenic tumors in the Thai population. ( 25773801 )
2015
49
Enucleation of large keratocystic odontogenic tumor at mandible via unilateral sagittal split osteotomy: a report of three cases. ( 26339581 )
2015
50
Simultaneous occurrence of keratocystic odontogenic tumor and ameloblastoma in the mandible: A case report. ( 26622570 )
2015

Variations for Keratocystic Odontogenic Tumor

Expression for Keratocystic Odontogenic Tumor

Search GEO for disease gene expression data for Keratocystic Odontogenic Tumor.

Pathways for Keratocystic Odontogenic Tumor

Pathways related to Keratocystic Odontogenic Tumor according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 BCL2 BIRC5 CCND1 MMP9 PTGS2 TNFSF11
2
Show member pathways
12.93 GLI1 MMP9 PTCH1 PTGS2 SMO SUFU
3
Show member pathways
12.8 BCL2 BIRC5 CCND1 MMP9 TP53
4
Show member pathways
12.68 BCL2 CCND1 FHIT MMP9 TP53
5
Show member pathways
12.67 BCL2 CCND1 SHH TNFSF11 TP53
6
Show member pathways
12.49 GLI1 PTCH1 SHH SMO SUFU
7
Show member pathways
12.47 BCL2 BIRC5 CCND1 MMP9 PTGS2 TP53
8 12.42 BCL2 BIRC5 CCND1 GLI1 MMP9 PTCH1
9 12.41 BCL2 CCND1 MMP9 PTGS2 TP53
10
Show member pathways
12.35 PTCH1 PTHLH SHH SMO
11 12.14 GLI1 PTCH1 SHH SUFU
12 12.11 BIRC5 CCND1 MMP9 PTGS2 TP53
13 12.1 CCND1 HPSE MMP9 PTCH1 SHH SMO
14
Show member pathways
12.02 GLI1 PTCH1 SHH SMO SUFU TP53
15 11.9 CCND1 MMP9 PTGS2 TP53
16 11.87 BCL2 PTHLH TNFSF11
17 11.86 BCL2 BIRC5 CCND1 MMP9 PTGS2 TP53
18 11.82 BCL2 PTGS2 TNFSF11
19
Show member pathways
11.81 BCL2 CCND1 GLI1 PTCH1 SHH SMO
20 11.78 MMP9 PDPN PTGS2
21 11.77 BCL2 CCND1 FHIT PTGS2 TP53
22 11.73 BIRC5 MMP9 TP53
23 11.72 CCND1 CTNNBIP1 MMP9
24 11.71 BCL2 CCND1 PTGS2
25
Show member pathways
11.67 BCL2 BIRC5 TNFSF11
26 11.66 CCND1 MMP9 TP53
27 11.66 BCL2 BIRC5 TP53
28
Show member pathways
11.61 BIRC5 CCND1 MMP9 PTGS2
29 11.58 MMP9 PTCH1 PTHLH
30 11.47 BIRC5 CCND1 PTGS2 TP53
31 11.45 BCL2 CCND1 TP53
32 11.29 BIRC5 PTGS2 TP53
33
Show member pathways
11.25 PTCH1 PTHLH SHH SMO
34 10.76 CCND1 GLI1 PTCH1 PTHLH SHH SMO
35 10.5 PTCH1 SHH

GO Terms for Keratocystic Odontogenic Tumor

Cellular components related to Keratocystic Odontogenic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cilium GO:0005929 9.62 GLI1 PTCH1 SMO SUFU
2 caveola GO:0005901 9.13 PTCH1 PTGS2 SMO
3 ciliary tip GO:0097542 8.8 GLI1 SMO SUFU
4 cytosol GO:0005829 10.03 BCL2 BIRC5 CALB2 CCND1 CTNNBIP1 FHIT
5 cytoplasm GO:0005737 10 BCL2 BIRC5 CALB2 CCND1 CTNNBIP1 FHIT

Biological processes related to Keratocystic Odontogenic Tumor according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.98 BCL2 PTHLH SHH SMO
2 anterior/posterior pattern specification GO:0009952 9.88 CTNNBIP1 SHH SMO
3 response to estradiol GO:0032355 9.87 CCND1 PTCH1 PTGS2
4 lung development GO:0030324 9.87 GLI1 PDPN SHH
5 negative regulation of apoptotic process GO:0043066 9.86 BCL2 BIRC5 MMP9 PDPN PTGS2 SHH
6 determination of left/right symmetry GO:0007368 9.85 SHH SMO SUFU
7 negative regulation of DNA binding transcription factor activity GO:0043433 9.84 CTNNBIP1 PTCH1 SUFU
8 ossification GO:0001503 9.84 BCL2 MMP9 SMO TNFSF11
9 response to glucocorticoid GO:0051384 9.83 BCL2 CCND1 PTGS2
10 heart looping GO:0001947 9.83 SHH SMO SUFU
11 negative regulation of Wnt signaling pathway GO:0030178 9.82 CCND1 CTNNBIP1 SHH
12 pattern specification process GO:0007389 9.82 PTCH1 SHH SMO
13 canonical Wnt signaling pathway GO:0060070 9.81 CCND1 GLI1 SHH SMO
14 embryonic organ development GO:0048568 9.79 PTCH1 SHH SMO
15 liver regeneration GO:0097421 9.79 CCND1 GLI1 PTCH1
16 positive regulation of smoothened signaling pathway GO:0045880 9.76 GLI1 SHH SMO
17 smoothened signaling pathway GO:0007224 9.76 GLI1 PTCH1 SHH SMO
18 positive regulation of protein import into nucleus GO:0042307 9.75 PTGS2 SHH SMO
19 developmental growth GO:0048589 9.74 BCL2 SHH SMO
20 hair follicle morphogenesis GO:0031069 9.73 BCL2 SHH SMO
21 renal system development GO:0072001 9.72 PTCH1 SHH SMO
22 mammary gland epithelial cell differentiation GO:0060644 9.69 PTCH1 SMO
23 regulation of mitochondrial membrane permeability GO:0046902 9.69 BCL2 TP53
24 thalamus development GO:0021794 9.69 SHH SMO
25 cellular response to cholesterol GO:0071397 9.68 PTCH1 SMO
26 negative regulation of epithelial cell differentiation GO:0030857 9.68 CCND1 SMO
27 mitotic G1 DNA damage checkpoint GO:0031571 9.68 CCND1 TP53
28 mammary gland epithelial cell proliferation GO:0033598 9.67 CCND1 TNFSF11
29 prostate gland development GO:0030850 9.67 GLI1 PTCH1 SHH
30 branching involved in ureteric bud morphogenesis GO:0001658 9.67 BCL2 CTNNBIP1 PTCH1 SHH
31 somite development GO:0061053 9.65 PTCH1 SHH SMO
32 lymphoid progenitor cell differentiation GO:0002320 9.64 BCL2 SHH
33 spinal cord dorsal/ventral patterning GO:0021513 9.63 SHH SUFU
34 cerebellar cortex morphogenesis GO:0021696 9.63 GLI1 SMO
35 epithelial-mesenchymal cell signaling GO:0060684 9.62 SHH SMO
36 dorsal/ventral pattern formation GO:0009953 9.62 GLI1 PTCH1 SHH SMO
37 determination of left/right asymmetry in lateral mesoderm GO:0003140 9.61 SHH SMO
38 digestive tract morphogenesis GO:0048546 9.61 BCL2 GLI1 SHH
39 positive regulation of hh target transcription factor activity GO:0007228 9.6 SHH SMO
40 ventral midline development GO:0007418 9.59 GLI1 SHH
41 dorsal/ventral neural tube patterning GO:0021904 9.58 PTCH1 SHH SMO
42 positive regulation of cell proliferation GO:0008284 9.56 BCL2 BIRC5 CCND1 GLI1 PTGS2 PTHLH
43 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.33 GLI1 SHH SMO
44 cytokine-mediated signaling pathway GO:0019221 9.17 BCL2 BIRC5 CCND1 MMP9 PTGS2 TNFSF11
45 multicellular organism development GO:0007275 10.21 GLI1 PDPN SHH SMO SUFU TNFSF11
46 negative regulation of transcription by RNA polymerase II GO:0000122 10.14 CCND1 PTCH1 SHH SMO SUFU TP53
47 negative regulation of cell proliferation GO:0008285 10 BCL2 PDPN PTCH1 PTGS2 PTHLH TP53

Molecular functions related to Keratocystic Odontogenic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 BCL2 BIRC5 CCND1 CTNNBIP1 FHIT GLI1
2 chaperone binding GO:0051087 9.33 BIRC5 PDPN TP53
3 patched binding GO:0005113 8.8 PTCH1 SHH SMO

Sources for Keratocystic Odontogenic Tumor

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