VAD
MCID: KRT002
MIFTS: 47

Keratomalacia (VAD)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Keratomalacia

MalaCards integrated aliases for Keratomalacia:

Name: Keratomalacia 12 74 52 54 43 15 71
Vitamin a Deficiency 52 54 71
Retinol Deficiency 52 71
Xerotic Keratitis 52 71
Night Blindness 52 71
Vitamin a 42
Vad 47

Classifications:



External Ids:

Disease Ontology 12 DOID:11267
ICD9CM 34 371.45
MeSH 43 C536156
SNOMED-CT 67 85149007
ICD10 32 H18.44
UMLS 71 C0028077 C0042842 C0152455 more

Summaries for Keratomalacia

MedlinePlus : 42 Vitamins are substances that your body needs to grow and develop normally. Vitamin A plays a role in your Vision Bone growth Reproduction Cell functions Immune system Vitamin A is an antioxidant. It can come from plant or animal sources. Plant sources include colorful fruits and vegetables. Animal sources include liver and whole milk. Vitamin A is also added to foods like cereals. Vegetarians, young children, and alcoholics may need extra Vitamin A. You might also need more if you have certain conditions, such as liver diseases, cystic fibrosis, and Crohn's disease. Check with your health care provider to see if you need to take vitamin A supplements. NIH: National Institutes of Health Office of Dietary Supplements

MalaCards based summary : Keratomalacia, also known as vitamin a deficiency, is related to xerophthalmia and congenital stationary night blindness, and has symptoms including photophobia, amaurosis fugax and metamorphopsia. An important gene associated with Keratomalacia is RHO (Rhodopsin). The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 74 Keratomalacia is an eye disorder that results from vitamin A deficiency. Vitamin A is required to... more...

Related Diseases for Keratomalacia

Diseases related to Keratomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1014)
# Related Disease Score Top Affiliating Genes
1 xerophthalmia 30.6 RHO DNASE1L1
2 congenital stationary night blindness 13.0
3 night blindness, congenital stationary, type 1a 13.0
4 night blindness, congenital stationary, type 1b 12.9
5 x-linked congenital stationary night blindness 12.9
6 night blindness, congenital stationary, type 2a 12.9
7 night blindness, congenital stationary, type 1e 12.9
8 night blindness, congenital stationary, type 1d 12.9
9 night blindness, congenital stationary, type 1f 12.9
10 night blindness, congenital stationary, autosomal dominant 2 12.9
11 night blindness, congenital stationary, type 1c 12.9
12 night blindness, congenital stationary, autosomal dominant 1 12.9
13 night blindness, congenital stationary, autosomal dominant 3 12.9
14 night blindness, congenital stationary, type 1h 12.9
15 night blindness, congenital stationary, type 1g 12.8
16 autosomal recessive congenital stationary night blindness 12.8
17 autosomal dominant congenital stationary night blindness 12.8
18 night blindness, congenital stationary, type1i 12.7
19 night blindness-skeletal anomalies-dysmorphism syndrome 12.6
20 acquired night blindness 12.6
21 hereditary hypercarotenemia and vitamin a deficiency 12.5
22 hypercarotenemia and vitamin a deficiency, autosomal recessive 12.5
23 oguchi disease 12.5
24 cone-rod synaptic disorder, congenital nonprogressive 12.4
25 oguchi disease 1 12.4
26 chondroectodermal dysplasia with night blindness 12.4
27 oguchi disease 2 12.4
28 retinal cone dystrophy 3a 12.0
29 retinal cone dystrophy 3b 12.0
30 fundus albipunctatus 11.8
31 choroideremia 11.7
32 enhanced s-cone syndrome 11.7
33 late-onset retinal degeneration 11.7
34 vascular dementia 11.7
35 retinitis pigmentosa 11.7
36 cone-rod dystrophy 2 11.6
37 gyrate atrophy of choroid and retina 11.6
38 leber congenital amaurosis 2 11.5
39 melanoma-associated retinopathy 11.5
40 refsum disease, classic 11.4
41 bietti crystalline corneoretinal dystrophy 11.4
42 pagod syndrome 11.3
43 microphthalmia 11.3
44 bothnia retinal dystrophy 11.3
45 cone-rod dystrophy 16 11.3
46 retinitis pigmentosa 84 11.3
47 lung cancer 11.2
48 abetalipoproteinemia 11.2
49 carotenemia 11.1
50 chylomicron retention disease 11.1

Graphical network of the top 20 diseases related to Keratomalacia:



Diseases related to Keratomalacia

Symptoms & Phenotypes for Keratomalacia

UMLS symptoms related to Keratomalacia:


photophobia, amaurosis fugax, metamorphopsia, other specified visual disturbances, visual disturbance, subjective visual disturbance, unspecified, visual manifestations

GenomeRNAi Phenotypes related to Keratomalacia according to GeneCards Suite gene sharing:

26 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-117 9.92 SLC26A1 NIN
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.92 NIN
3 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.92 NIN
4 Increased shRNA abundance (Z-score > 2) GR00366-A-150 9.92 NIN
5 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.92 SLC26A1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-160 9.92 QDPR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.92 QDPR
8 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.92 MPG QDPR SLC26A1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-193 9.92 MPG
10 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.92 MPG
11 Increased shRNA abundance (Z-score > 2) GR00366-A-203 9.92 QDPR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-27 9.92 NIN
13 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.92 SLC26A1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-33 9.92 SLC26A1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.92 SLC26A1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.92 NIN
17 Increased shRNA abundance (Z-score > 2) GR00366-A-62 9.92 MPG
18 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.92 SLC26A1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.92 SLC26A1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.92 SLC26A1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.92 NIN
22 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.92 SLC26A1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-89 9.92 MPG

MGI Mouse Phenotypes related to Keratomalacia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.23 EN2 MPG NIN QDPR RHO SLC26A1

Drugs & Therapeutics for Keratomalacia

Drugs for Keratomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 403)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Racepinephrine Approved Phase 4 329-65-7 838
3
Ethanol Approved Phase 4 64-17-5 702
4
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
5
chloroquine Approved, Investigational, Vet_approved Phase 4 54-05-7 2719
6
Nifedipine Approved Phase 4 21829-25-4 4485
7
Ranibizumab Approved Phase 4 347396-82-1 459903
8
Tazarotene Approved, Investigational Phase 4 118292-40-3 5381
9
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
10
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
11
Adapalene Approved Phase 4 106685-40-9 60164
12
Benzoyl peroxide Approved Phase 4 94-36-0 7187
13
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
14
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
15
Acitretin Approved Phase 4 55079-83-9, 69427-46-9 6437841
16
Pyrantel Approved, Vet_approved Phase 4 15686-83-6
17
Povidone Approved Phase 4 9003-39-8
18
Warfarin Approved Phase 4 81-81-2 6691 54678486
19
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
20
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
21
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
22
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
23
Castor oil Approved, Investigational, Nutraceutical, Vet_approved Phase 4 8001-79-4
24
Beta carotene Approved, Nutraceutical Phase 4 7235-40-7
25
Coumarin Experimental Phase 4 91-64-5 323
26
BCG vaccine Investigational Phase 4
27 polysaccharide-K Phase 4
28 Immunologic Factors Phase 4
29 Adjuvants, Immunologic Phase 4
30 Epinephryl borate Phase 4
31 Zinc Supplement Phase 4
32 Anthelmintics Phase 4
33 Tubulin Modulators Phase 4
34 Antimitotic Agents Phase 4
35 Chloroquine diphosphate Phase 4 50-63-5
36 Carbopol 940 Phase 4
37 BB 1101 Phase 4
38
protease inhibitors Phase 4
39 HIV Protease Inhibitors Phase 4
40 Tocolytic Agents Phase 4
41 calcium channel blockers Phase 4
42 Angiogenesis Inhibitors Phase 4
43 Hypolipidemic Agents Phase 4
44 Lipid Regulating Agents Phase 4
45 Antimetabolites Phase 4
46 Castor Phase 4
47 Cathartics Phase 4
48 Cyclosporins Phase 4
49 Immunosuppressive Agents Phase 4
50 Antifungal Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 470)
# Name Status NCT ID Phase Drugs
1 Should Infants Receive High-dose Vitamin A Supplementation With BCG Vaccine at Birth in Developing Countries? Randomized Prospective Studies in Guinea-Bissau Unknown status NCT00168610 Phase 4 Vitamin A
2 Randomised Trial of Vitamin A Supplementation Given With Routine Childhood Vaccines at National Immunisation Days Unknown status NCT00168623 Phase 4 Vitamin A
3 The Study of the Effects of Vitamin A Supplementation on Immune System and Th1/Th2 Balance in Patients With Atherosclerosis Unknown status NCT00963222 Phase 4 vitamin A;placebo
4 The Effect of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by T CD4+ Lymphocyte in Atherosclerotic Patients Unknown status NCT01414972 Phase 4 Vitamin A;placebo
5 The Impact of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by CD4+ T Lymphocyte in Multiple Sclerosis Patients Unknown status NCT01407211 Phase 4
6 Impact of Vitamin A Supplementation on RAR Gene Expression in PBMC Cells in Multiple Sclerotic Patients Unknown status NCT01705457 Phase 4 Dietary Supplement: vitamin A;placebo
7 The Effect of a Nutrient Fortified Oat Drink on Iron, Zinc, Vitamin A, and Vitamin C Status Among Filipino Children Unknown status NCT01418898 Phase 4
8 Impact of Vitamin A Supplementation on Disease Activity and Progression in Multiple Sclerotic (MS) Patients Unknown status NCT01417273 Phase 4 Drug: placebo
9 The Effect of Vitamin A Supplementation on CD4+ T-cell Secretion in Obese Individuals Unknown status NCT01405352 Phase 4
10 The Impact of Vitamin on the Clinical Course in Cases Infected by Novel H1N1 Influenza Virus A: a Randomized-controlled Trial Unknown status NCT01127282 Phase 4 Vitamin (vitamin A 15 mg,C 500 mg, E 400IU);Placebo (digestive tablet)
11 Eight Week Feasibility Study Enrolling Dry Eye Subjects Confirmed by Four of Seven Dianostic Markers Responding to Nutritional Therapy Unknown status NCT01561040 Phase 4
12 Adrenal Cortical Function and Vitamin A Deficiency in Sepsis, Severe Sepsis and Septic Shock: Prospective Randomized, Double Blind Placebo Controlled Clinical Trials Completed NCT03152474 Phase 4 Solumedrol 20mg;Vitamin A 100,000 IU
13 Should Infants Receive High-dose Vitamin A Supplementation With BCG Vaccine at Birth in Developing Countries? Completed NCT00168597 Phase 4 Vitamin A
14 The Study of the Effects of Vitamin A Supplementation on Immune System and Th1/Th2 Balance in Patients With Multiple Sclerosis Completed NCT01225289 Phase 4 Placebo
15 Comparison of the Efficacy and Acceptability of Three Types of Micronutrient Supplements Added to Complementary Foods for Infants in Ghana Completed NCT00379158 Phase 4 Micronutrient supplements
16 Deworming and Enhanced Vitamin A Supplementation DEVTA Project Completed NCT00222547 Phase 4 Vitamin A;Albendazole
17 Effect of SLC30A8 rs13266634 Genetic Polymorphism on Zinc Supplementation and Glycemic Control in Egyptian Patients With Type 2 Diabetes Mellitus Completed NCT03112382 Phase 4 zinc supplement plus vitamin A and E;vitamin A and E
18 Randomised Study of the Impact of Different Doses of Vitamin A on Childhood Morbidity and Mortality Completed NCT00168584 Phase 4 Vitamin A
19 Vitamin A and Zinc: Prevention of Pneumonia (VAZPOP) Study Completed NCT00228254 Phase 4 Zinc (12.5 mg/day);vitamin A 10,000 IU per week
20 Does Additional Vitamin A Supplementation Improve Retinal Function and Conjunctival Health in Very Low Birthweight Infants? Completed NCT00417404 Phase 4 Aquasol A;aquasol A
21 The Impact of Different Doses of Vitamin A Supplementation on Male and Female Childhood Morbidity and Mortality Completed NCT00168636 Phase 4 Vitamin A
22 The Effect of Zinc, Beta-carotene, and Vitamin D3 Supplementation as Pro-inflammation Mediated Regulator in Preterm Delivery Through Placental Protein Adaptor MyD88 and TRIF, Transcription Factor NFkB, and Pro-inflammatory Cytokine IL-1β Completed NCT03005496 Phase 4 Zinc;Nifedipine;Beta Carotene;Vitamin D3;Dexamethasone
23 Prospective, Single-center, Six-month Study of Intravitreal Ranibizumab for Macular Edema With Nonproliferative Diabetic Retinopathy: Effects on Microaneurysm Turnover and Non-perfused Retinal Area Completed NCT02834663 Phase 4 Lucentis
24 Chengdu Women's and Children's Central Hospital Completed NCT02675140 Phase 4 ZENTEL;ZENTEL and Vitamin A Soft Capsules
25 Discovery of Effects of Retinol on Human Skin Aging in Individuals of East Asian Descent Completed NCT02906566 Phase 4 Retinol;Placebo
26 Single Center, Open-Label, Efficacy and Safety Study of Tazarotene (Tazorac) for the Treatment of Brittle Nails Completed NCT00648986 Phase 4 Tazorac
27 Safety Study of the Use of Topical Cyclosporine in the Treatment of Dry Eye Disease Completed NCT02004067 Phase 4 Restasis;Refresh Endura
28 Effect of Sample Medication Use and Application Instructions on Adherence to and Efficacy of Treatment of Patients With Mild to Moderate Acne With Epiduo(R) Gel Completed NCT01504204 Phase 4 Adapalene + benzoyl peroxide samples;Adapalene + benzoyl peroxide from standard tube
29 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso Completed NCT00642408 Phase 4
30 Effect of Antioxidants on Ocular Blood Flow, Endothelial Function, and Cytokine Levels in LPS Induced Inflammatory Model in Humans. Completed NCT00431691 Phase 4 vitamin and mineral supplement;Escherichia coli Endotoxin (LPS);100% O2;nitroglycerin
31 A Preliminary, Open Label, Single-arm Study to Determine the Efficacy of Taclonex Topical Suspension as a Supplement to Non-biologic Systemic Therapy Completed NCT01761019 Phase 4 Taclonex Topical Suspension
32 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso: the Malaria Component Completed NCT00680732 Phase 4 Chloroquine (CQ);Sulphadoxyne-pyrimethamine (SP)
33 Longitudinal Study of Efficacy of Standard Albendazole Treatment Versus Levamisole/Pyrantel Pamoate on Soil Transmitted Helminth Infections Completed NCT00659997 Phase 4 Albendazole;Levamisole
34 Effect of Prenatal Nutritional Supplementation on Birth Outcome in Hounde District, Burkina Faso Completed NCT00909974 Phase 4
35 Diarrhea, Malaria, Anemia, and Helminthiasis Prevention Through Household-based Interventions in Rural Western Kenya: the Nyando Integrated Child Health and Education (NICHE) Project Completed NCT01088958 Phase 4
36 Comparison of Autologous Serum Versus Preservative Free Artificial Tear in Patients With Dry Eye Due to Systemic Isotretinoin Therapy Completed NCT02752763 Phase 4 %40 diluted Autologous serum;Preservative free artificial tears(Tears naturale free, Refresh single dose eye drop)
37 A Comparative Randomized Controlled Study of Arginine Free Immunoenhancing Diet and Isocaloric, Isonitrogenous Formula in Critically Ill Patients Completed NCT01713257 Phase 4
38 PRELIMINARY EVALUATION OF RETINAL EFFECTS OF PHARMACOLOLOGICAL LOWERING OF SERUM LEVES OF ADVANCED GLYCATION END-PRODUCTS (AGEs) IN TYPE 2 DIABETIC PATIENTS Completed NCT02249897 Phase 4 CHOLESTYRAMINE
39 Therapeutic Equivalence Between Branded and Generic Warfarin Sodium Tablets in Adult Patients With Atrial Fibrillation in Brazil - Crossover Randomized Controlled Equivalence Trial Completed NCT02017197 Phase 4 Marevan®;generic warfarin #1;generic warfarin #2
40 Measles Vaccination in Guinea-Bissau. Strategies to Reduce Disease Burden and Improve Child Survival Completed NCT00168558 Phase 4
41 The Effect of Co-administered β-Carotene, Vitamin D3, Zinc and Antenatal Steroid Therapy on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Recruiting NCT03366584 Phase 4 Dexamethasone
42 Neonates and Azithromycin, an Innovation in the Treatment of Children in Burkina Faso Recruiting NCT03682653 Phase 4 Azithromycin;Placebo
43 Community Health Azithromycin Trial in Burkina Faso Recruiting NCT03676764 Phase 4 Azithromycin;Placebos
44 Randomized Trial Evaluating the Non-specific Effects of Different BCG Strains in Guinea-Bissau: Effects on Early-life Mortality and Morbidity Recruiting NCT04383925 Phase 4
45 Evaluating the Non-specific Effects of Different BCG Strains in Guinea-Bissau: Randomized Trial of the Impact on Early-life Hospital Admissions and Deaths Active, not recruiting NCT03400878 Phase 4
46 Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD:A Randomized, Double Blind, Placebo-controlled, Multicentric Trial. Not yet recruiting NCT04284059 Phase 4 Placebos
47 Anti-inflammatory/Antioxidant Oral Nutrition Supplementation on the Cytokine Storm and Progression of COVID-19: A Randomized Controlled Trial Not yet recruiting NCT04323228 Phase 4
48 Evaluation of the Impact on Mortality and Morbidity of the WHO Recommended Vitamin A Supplementation at First Immunisation Contact After 6 Months of Age Terminated NCT00514891 Phase 4
49 Intratracheal Vitamin A Administration With Surfactant for Newborn Respiratory Distress Syndrome Unknown status NCT01265589 Phase 3 surfactant;surfactant+vitamin A
50 Long-term Impact and Intervention for Diarrhea in Brazil Unknown status NCT00133406 Phase 3 Glutamine;Vitamin A;glycine;zinc

Search NIH Clinical Center for Keratomalacia

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Cod Liver Oil
retinol acetate
retinyl palmitate
Vitamin A
VITAMIN A (AS ACETATE & BETA CAROTENE)
VITAMIN A (AS PALMITATE & BETA CAROTENE)
VITAMIN A (NATURAL)
VITAMIN A PALMITATE (SOLUBILIZED)

Cochrane evidence based reviews: keratomalacia

Genetic Tests for Keratomalacia

Anatomical Context for Keratomalacia

MalaCards organs/tissues related to Keratomalacia:

40
Liver, Eye, Testes, Lung, Breast, Bone, Skin

Publications for Keratomalacia

Articles related to Keratomalacia:

(show top 50) (show all 3643)
# Title Authors PMID Year
1
Vitamin A and Wound Healing. 42 61
31697447 2019
2
Observation for clinical effect of acupuncture combined with conventional therapy in the treatment of acne vulgaris. 42
32358349 2020
3
50 Years Ago in TheJournal ofPediatrics: Vitamin A and Mucopolysaccharidosis: A clinical and biochemical evaluation. 42
31761145 2019
4
Chapter 29: historical aspects of the major neurological vitamin deficiency disorders: overview and fat-soluble vitamin A. 54 61
19892132 2010
5
Boosting carotenoid content in Malus domestica var. Fuji by expressing AtDXR through an Agrobacterium-mediated transformation method. 61
32311081 2020
6
Liver is widely eaten by preschool children in the Northern Cape province of South Africa: Implications for routine vitamin A supplementation. 61
31845541 2020
7
Nutritional status and intestinal parasites among young children from pastoralist communities of the Ethiopian Somali region. 61
32026575 2020
8
Sterile Corneal Perforation Occurring Several Years After Biliopancreatic Diversion. 61
32144634 2020
9
Retinoic Acid Modulates Hyperactive T Cell Responses and Protects Vitamin A-Deficient Mice against Persistent Lymphocytic Choriomeningitis Virus Infection. 61
32284332 2020
10
A Comparison of Vitamin and Lutein Concentrations in Breast Milk from Four Asian Countries. 61
32560305 2020
11
A global perspective of pediatric non-viral keratitis: literature review. 61
32500305 2020
12
Dietary β-Carotene Rescues Vitamin A Deficiency and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice. 61
32492795 2020
13
Vitamin A deficiency exacerbates extrinsic atopic dermatitis development by potentiating type 2 helper T cell-type inflammation and mast cell activation. 61
32559330 2020
14
Vitamin A deficiency exacerbates autism-like behaviors and abnormalities of the enteric nervous system in a valproic acid-induced rat model of autism. 61
32526256 2020
15
SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana. 61
32560166 2020
16
Cereal bran protects vitamin A from degradation during simmering and storage. 61
32559599 2020
17
Later puberty onset among chronically undernourished adolescents living in a Karachi slum, Pakistan. 61
31606907 2020
18
Dietary vitamin A intakes among pregnant women attending antenatal care in health facilities in Dessie Town, North East Ethiopia. 61
32424967 2020
19
Genetic engineering of eggplant accumulating β-carotene in fruit. 61
32382812 2020
20
Postpartum vitamin A supplementation for HIV-positive women is not associated with mortality and morbidity of their breastfed infants: evidence from multiple national surveys in sub-Saharan Africa. 61
32404193 2020
21
Diet and Nutrition Status of Mongolian Adults. 61
32456038 2020
22
Clinical characteristics and treatment of spontaneous chronic corneal epithelial defects (SCCEDs) with diamond burr debridement. 61
32379378 2020
23
A Rare Cause of Bilateral Corneal Ulcers: Vitamin A Deficiency in the Setting of Chronic Alcoholism. 61
32523846 2020
24
Prospects for Carotenoid Biofortification Targeting Retention and Catabolism. 61
31956035 2020
25
Metabolomics Reveals Altered Hepatic Bile Acids, Gut Microbiome Metabolites, and Cell Membrane Lipids Associated with Marginal Vitamin A Deficiency in a Mongolian Gerbil Model. 61
32453876 2020
26
An Integrated Infant and Young Child Feeding and Micronutrient Powder Intervention Does Not Affect Anemia, Iron Status, or Vitamin A Status among Children Aged 12-23 Months in Eastern Uganda. 61
31923315 2020
27
Nutritional status of Tajik children and women: Transition towards a double burden of malnutrition. 61
31702104 2020
28
A multifocal approach towards understanding the complexities of carotenoid biosynthesis and accumulation in rice grains. 61
32240289 2020
29
Equine non-healing corneal ulcers: a retrospective evaluation of 57 cases (2001-2017). 61
32325498 2020
30
Outcome of medical therapy for keratomalacia in dogs. 61
32065393 2020
31
Inconsistently impairment of immune function and structural integrity of head kidney and spleen by vitamin A deficiency in grass carp (Ctenopharyngodon idella). 61
32058097 2020
32
Intramuscular Followed by Oral Vitamin A Supplementation in Neonates with Birth Weight from 750 to 1250 g: A Randomized Controlled Trial. 61
32226251 2020
33
Retinol status and associated factors in mother-newborn pairs. 61
31602713 2020
34
Caregiver Perceptions and Acceptability of a Provitamin A Carotenoid, Iron and Zinc Rich Complementary Food Blend Prepared from Common Bean and Pumpkin in Rural Uganda. 61
32224909 2020
35
Vitamin A supplement after neonatal Streptococcus pneumoniae pneumonia inhibits the progression of experimental asthma by altering CD4+T cell subsets. 61
32144294 2020
36
Cactus-induced keratoconjunctivitis in Texas: A case series of three dogs and one cat. 61
31544314 2020
37
Understanding innovation: The development and scaling of orange-fleshed sweetpotato in major African food systems. 61
32127727 2020
38
Vitamin A and iron status of children before and after treatment of uncomplicated severe acute malnutrition. 61
32249112 2020
39
Bilateral Keratomalacia Leading to Blindness Secondary to Diet-Induced Vitamin A Deficiency in Infants. 61
32176803 2020
40
Vitamin A deficiency increases the risk of gastrointestinal comorbidity and exacerbates core symptoms in children with autism spectrum disorder. 61
32225174 2020
41
Prenatal Zinc and Vitamin A Reduce the Benefit of Iron on Maternal Hematologic and Micronutrient Status at Delivery in Tanzania. 61
31618430 2020
42
Carotenoid biofortification in crop plants: citius, altius, fortius. 61
32068105 2020
43
Sensory Analysis of a Processed Food Intended for Vitamin A Supplementation. 61
32098146 2020
44
Prevalence of ocular morbidities among school children in Raipur district, India. 61
31957723 2020
45
Vitamin A deficiency is associated with severe Mycoplasma pneumoniae pneumonia in children. 61
32175413 2020
46
Economic impact of dry eye disease in Spain: A multicentre retrospective insurance claims database analysis. 61
32064919 2020
47
Tribal Odisha Eye Disease Study Report # 6. Opportunistic screening of vitamin A deficiency through School Sight Program in tribal Odisha (India). 61
31957725 2020
48
Micronutrient intake and prevalence of micronutrient inadequacy among women (15-49 y) and children (6-59 mo) in South Kivu and Kongo Central, Democratic Republic of the Congo (DRC). 61
32530922 2020
49
Prevalence and Risk Factors for Iron Deficiency in Adults With Cystic Fibrosis. 61
31994790 2020
50
Pro-vitamin A carotenoids in East African highland banana and other Musa cultivars grown in Uganda. 61
31993157 2020

Variations for Keratomalacia

Expression for Keratomalacia

Search GEO for disease gene expression data for Keratomalacia.

Pathways for Keratomalacia

GO Terms for Keratomalacia

Biological processes related to Keratomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anion transmembrane transport GO:0098656 8.96 SLC4A3 SLC26A1
2 bicarbonate transport GO:0015701 8.62 SLC4A3 SLC26A1

Molecular functions related to Keratomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antiporter activity GO:0015297 9.16 SLC4A3 SLC26A1
2 anion:anion antiporter activity GO:0015301 8.96 SLC4A3 SLC26A1
3 bicarbonate transmembrane transporter activity GO:0015106 8.62 SLC4A3 SLC26A1

Sources for Keratomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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