VAD
MCID: KRT002
MIFTS: 56

Keratomalacia (VAD)

Categories: Endocrine diseases, Eye diseases, Metabolic diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Keratomalacia

MalaCards integrated aliases for Keratomalacia:

Name: Keratomalacia 11 19 75 53 43 14 71
Vitamin a Deficiency 19 53 16 71 31 33
Retinol Deficiency 19 71
Xerotic Keratitis 19 71
Night Blindness 19 71
Vitamin a Deficiency with Cornea Ulceration or Xerosis 33
Vitamin a Deficiency with Cornea Xerosis 33
Conjunctival Xerosis with Bitot's Spots 33
Bitot Spots in the Young Child 33
Hypovitaminosis a 33
Bitot Spots 33
Vitamin a 41
Vad 47

Classifications:



External Ids:

Disease Ontology 11 DOID:11267
ICD9CM 34 371.45
MeSH 43 C536156
SNOMED-CT 68 85149007
UMLS 71 C0028077 C0042842 C0152455 more

Summaries for Keratomalacia

MedlinePlus: 41 Vitamins are substances that your body needs to grow and develop normally. Vitamin A plays a role in your: Vision Bone growth Reproduction Cell functions Immune system Vitamin A is an antioxidant. It can come from plant or animal sources. Plant sources include colorful fruits and vegetables. Animal sources include liver and whole milk. Vitamin A is also added to foods like cereals. Vegetarians, young children, and alcoholics may need extra Vitamin A. You might also need more if you have certain conditions, such as liver diseases, cystic fibrosis, and Crohn's disease. Check with your health care provider to see if you need to take vitamin A supplements. NIH: National Institutes of Health Office of Dietary Supplements

MalaCards based summary: Keratomalacia, also known as vitamin a deficiency, is related to leber congenital amaurosis 2 and xerophthalmia, and has symptoms including photophobia, amaurosis fugax and metamorphopsia. An important gene associated with Keratomalacia is RBP4 (Retinol Binding Protein 4), and among its related pathways/superpathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. The drugs BCG vaccine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and digestive/alimentary

GARD: 19 dryness with ulceration and perforation of the cornea, with absence of inflammatory reactions, occurring in cachectic children; results from severe vitamin A deficiency.

Wikipedia: 75 Keratomalacia is an eye disorder that results from vitamin A deficiency. Vitamin A is required to... more...

Related Diseases for Keratomalacia

Diseases related to Keratomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1229)
# Related Disease Score Top Affiliating Genes
1 leber congenital amaurosis 2 31.7 RHO LRAT
2 xerophthalmia 31.7 TTR RHO RARS1
3 carotenemia 31.6 TTR CYP26A1
4 night blindness 30.2 RHO RBP4 LRAT
5 hypervitaminosis a 29.9 TTR RBP4 RARS1 LRAT CYP26A1
6 coloboma, ocular, autosomal dominant 29.9 RBP4 RARB
7 intracranial hypertension, idiopathic 29.8 RBP4 RARA
8 stargardt disease 29.8 RHO RBP4 LRAT
9 diaphragmatic hernia, congenital 29.8 RARB LRAT CYP26A1
10 acute promyelocytic leukemia 29.8 RARS1 RARB RARA CYP26A1
11 amyloidosis, hereditary, transthyretin-related 29.7 TTR RBP4
12 protein-energy malnutrition 29.6 TTR RBP4
13 coloboma of macula 29.6 RHO RBP4 RARB
14 squamous cell carcinoma, head and neck 29.6 RARS1 RARB RARA CYP26A1
15 teratocarcinoma 29.3 RARS1 RARB RARA
16 microphthalmia, syndromic 9 29.2 RBP4 RARS1 RARB LRAT CYP26A1
17 embryonal carcinoma 29.1 RARS1 RARB RARA CYP26A1
18 x-linked congenital stationary night blindness 11.9
19 congenital stationary night blindness 11.9
20 night blindness, congenital stationary, type 1b 11.8
21 night blindness, congenital stationary, type 1h 11.8
22 night blindness, congenital stationary, type 1e 11.8
23 night blindness, congenital stationary, type 2a 11.8
24 night blindness, congenital stationary, type 1d 11.8
25 night blindness, congenital stationary, autosomal dominant 2 11.8
26 night blindness, congenital stationary, autosomal dominant 3 11.8
27 night blindness, congenital stationary, type 1f 11.8
28 night blindness, congenital stationary, type 1c 11.8
29 night blindness, congenital stationary, autosomal dominant 1 11.8
30 night blindness, congenital stationary, type1i 11.7
31 autosomal recessive congenital stationary night blindness 11.7
32 cone-rod synaptic disorder, congenital nonprogressive 11.7
33 night blindness, congenital stationary, type 1g 11.7
34 hypercarotenemia and vitamin a deficiency, autosomal dominant 11.7
35 oguchi disease 2 11.7
36 oguchi disease 1 11.6
37 autosomal dominant congenital stationary night blindness 11.6
38 retinal cone dystrophy 3b 11.6
39 oguchi disease 11.6
40 hereditary hypercarotenemia and vitamin a deficiency 11.6
41 retinal cone dystrophy 3a 11.6
42 night blindness-skeletal anomalies-dysmorphism syndrome 11.5
43 chondroectodermal dysplasia with night blindness 11.4
44 fundus albipunctatus 11.4
45 acquired night blindness 11.3
46 choroideremia 11.3
47 enhanced s-cone syndrome 11.3
48 cone-rod dystrophy 2 11.3
49 late-onset retinal degeneration 11.3
50 retinitis pigmentosa 11.3

Graphical network of the top 20 diseases related to Keratomalacia:



Diseases related to Keratomalacia

Symptoms & Phenotypes for Keratomalacia

UMLS symptoms related to Keratomalacia:


photophobia; amaurosis fugax; metamorphopsia; other specified visual disturbances; visual disturbance; subjective visual disturbance, unspecified; visual manifestations

GenomeRNAi Phenotypes related to Keratomalacia according to GeneCards Suite gene sharing:

25 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.77 CYP27C1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.77 RARA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.77 CYP26A1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.77 CYP27C1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.77 CYP27C1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-160 9.77 QDPR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.77 RARA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.77 CYP20A1 CYP26A1 CYP27C1 QDPR RARA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-184 9.77 RARA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.77 QDPR
11 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.77 CYP20A1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-203 9.77 QDPR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-204 9.77 CYP27C1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.77 CYP26A1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.77 CYP26A1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.77 CYP27C1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-40 9.77 CYP27C1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.77 CYP27C1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.77 CYP20A1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.77 CYP27C1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.77 CYP27C1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.77 CYP27C1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.77 CYP27C1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.77 CYP20A1

MGI Mouse Phenotypes related to Keratomalacia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 CLPS CYP26A1 EN2 RARA RARB RBP4

Drugs & Therapeutics for Keratomalacia

Drugs for Keratomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 113)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
BCG vaccine Approved, Investigational Phase 4
2
Racepinephrine Approved, Vet_approved Phase 4 51-43-4, 329-65-7 838 5816
3
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
4
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 4894 5755
6
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5 1875
7
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 4159 6741
8
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
9
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
10
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8 5280382 445354
11
Cholecalciferol Approved, Nutraceutical, Vet_approved Phase 4 67-97-0, 1406-16-2 5280795 10883523
12
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
13
Isotretinoin Approved, Investigational, Nutraceutical Phase 4 302-79-4, 4759-48-2 5538 444795 5282379
14
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7 4897
15 polysaccharide-K Phase 4
16 Anti-Infective Agents Phase 4
17 Epinephryl borate Phase 4
18 Antineoplastic Agents, Hormonal Phase 4
19 Neuroprotective Agents Phase 4
20 Hormone Antagonists Phase 4
21 Antiemetics Phase 4
22 glucocorticoids Phase 4
23 Anti-Inflammatory Agents Phase 4
24
Methylprednisolone Acetate Phase 4 584547
25 Gastrointestinal Agents Phase 4
26 Antimitotic Agents Phase 4
27 Antiprotozoal Agents Phase 4
28 Anthelmintics Phase 4
29 Antiparasitic Agents Phase 4
30 Tubulin Modulators Phase 4
31 Vitamins Phase 4
32 Trace Elements Phase 4
33 Micronutrients Phase 4
34 Retinol palmitate Phase 4
35 Calciferol Phase 4
36 Dermatologic Agents Phase 4
37 Calcium, Dietary Phase 4
38
Vitamin D2 Phase 4 3249
39 Hormones Phase 4
40 Ergocalciferols Phase 4
41 Keratolytic Agents Phase 4
42 Vaccines Phase 4
43
Calcium Nutraceutical Phase 4 7440-70-2 271
44
Zinc cation Approved, Experimental, Investigational Phase 3 7440-66-6, 23713-49-7 32051
45
Zinc sulfate Approved, Investigational Phase 3 7733-02-0
46 Orange Approved Phase 3
47
Levoleucovorin Approved, Experimental, Investigational Phase 3 68538-85-2, 58-05-9, 73951-54-9 149436 6006
48
Ferrous fumarate Approved Phase 3 141-01-5
49
Tocopherol Approved, Investigational Phase 3 1406-66-2
50
Selenium Approved, Investigational, Vet_approved Phase 3 7783-07-5, 7782-49-2 533

Interventional clinical trials:

(show top 50) (show all 150)
# Name Status NCT ID Phase Drugs
1 Impact of Vitamin A Supplementation on RAR Gene Expression in PBMC Cells in Multiple Sclerotic Patients Unknown status NCT01705457 Phase 4 Dietary Supplement: vitamin A;placebo
2 Randomised Trial of Vitamin A Supplementation Given With Routine Childhood Vaccines at National Immunisation Days Unknown status NCT00168623 Phase 4 Vitamin A
3 Should Infants Receive High-dose Vitamin A Supplementation With BCG Vaccine at Birth in Developing Countries? Randomized Prospective Studies in Guinea-Bissau Unknown status NCT00168610 Phase 4 Vitamin A
4 The Study of the Effects of Vitamin A Supplementation on Immune System and Th1/Th2 Balance in Patients With Atherosclerosis Unknown status NCT00963222 Phase 4 vitamin A;placebo
5 The Effect of a Nutrient Fortified Oat Drink on Iron, Zinc, Vitamin A, and Vitamin C Status Among Filipino Children Unknown status NCT01418898 Phase 4
6 The Impact of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by CD4+ T Lymphocyte in Multiple Sclerosis Patients Unknown status NCT01407211 Phase 4
7 The Effect of Vitamin A Supplementation on CD4+ T-cell Secretion in Obese Individuals Unknown status NCT01405352 Phase 4
8 The Effect of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by T CD4+ Lymphocyte in Atherosclerotic Patients Unknown status NCT01414972 Phase 4 Vitamin A;placebo
9 Impact of Vitamin A Supplementation on Disease Activity and Progression in Multiple Sclerotic (MS) Patients Unknown status NCT01417273 Phase 4 Drug: placebo
10 Adrenal Cortical Function and Vitamin A Deficiency in Sepsis, Severe Sepsis and Septic Shock: Prospective Randomized, Double Blind Placebo Controlled Clinical Trials Completed NCT03152474 Phase 4 Solumedrol 20mg;Vitamin A 100,000 IU
11 Does Additional Vitamin A Supplementation Improve Retinal Function and Conjunctival Health in Very Low Birthweight Infants? Completed NCT00417404 Phase 4 Aquasol A;aquasol A
12 The Impact of Different Doses of Vitamin A Supplementation on Male and Female Childhood Morbidity and Mortality Completed NCT00168636 Phase 4 Vitamin A
13 Should Infants Receive High-dose Vitamin A Supplementation With BCG Vaccine at Birth in Developing Countries? Completed NCT00168597 Phase 4 Vitamin A
14 Randomised Study of the Impact of Different Doses of Vitamin A on Childhood Morbidity and Mortality Completed NCT00168584 Phase 4 Vitamin A
15 Vitamin A and Zinc: Prevention of Pneumonia (VAZPOP) Study Completed NCT00228254 Phase 4 Zinc (12.5 mg/day);vitamin A 10,000 IU per week
16 Deworming and Enhanced Vitamin A Supplementation DEVTA Project Completed NCT00222547 Phase 4 Vitamin A;Albendazole
17 The Study of the Effects of Vitamin A Supplementation on Immune System and Th1/Th2 Balance in Patients With Multiple Sclerosis Completed NCT01225289 Phase 4 Placebo
18 Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD:A Randomized, Double Blind, Placebo-controlled, Multicentric Trial. Recruiting NCT04284059 Phase 4 Placebos
19 Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell. Not yet recruiting NCT05002530 Phase 4 Aerosolized 13 cis retinoic acid plus Vitamin D;Aerosolized All trans retinoic acid plus Vitamin D
20 Evaluation of the Impact on Mortality and Morbidity of the WHO Recommended Vitamin A Supplementation at First Immunisation Contact After 6 Months of Age Terminated NCT00514891 Phase 4
21 Effects of Fat-soluble Vitamins Supplementation in Early Life on Common Complications and Neural Development in Very Low Birth Weight Infants Unknown status NCT03876704 Phase 3 High dose of fat-Soluble Vitamin;Conventional dose of fat-Soluble Vitamin
22 Moringa Oleifera (Drumstick Leaves) for Improving Haemoglobin, Vitamin A Status and Underweight Among Adolescent Girls in Rural Bangladesh: A Quasi-experimental Study Unknown status NCT04156321 Phase 3
23 Intratracheal Vitamin A Administration With Surfactant for Newborn Respiratory Distress Syndrome Unknown status NCT01265589 Phase 3 surfactant;surfactant+vitamin A
24 Stopping Postpartum Vitamin A Supplementation: Are we Missing Concealed Benefit? Completed NCT02043223 Phase 2, Phase 3
25 Impact of Supplementation With Dual Megadose of Vitamin A in the Post-partum About Vitamin A Levels in Breast Milk, Serum Levels of Vitamin A and Iron in the Binomial Mother-son and Growth and Morbidity of Children Under 6 Months Completed NCT00742937 Phase 2, Phase 3
26 Efficacy of β-carotene Biofortified Maize in Improving Vitamin A Status and Reducing the Prevalence of Vitamin A Deficiency Among Children in Rural Zambia Completed NCT01695148 Phase 3
27 A Randomized Community Trial of Newborn Vitamin A Supplementation to Reduce Infant Mortality in Rural Bangladesh Completed NCT00128557 Phase 3
28 Randomised Double-blind Placebo-controlled Trial to Evaluate the Impact of Vitamin A on Maternal Mortality in Ghana Completed NCT00211341 Phase 3
29 Impact of Maternal Vitamin A or Beta-Carotene Supplementation on Maternal and Infant Mortality in Bangladesh Completed NCT00198822 Phase 3
30 Efficacy of Biofortified Maize to Improve Maternal and Infant Vitamin A Status Completed NCT02804490 Phase 3
31 Effect of Vitamin A in the Treatment of Sepsis and Necrotizing Enterocolitis in Hospitalized Neonates Completed NCT00707785 Phase 3
32 To Assess the Effectiveness of Six-Monthly Deworming With Vitamin A Administration on Growth in 1-5 Year Old Children in the Urban Slums of Lucknow Completed NCT00396500 Phase 3 Albendazole (400 mg) and/or Vitamin a
33 Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa Completed NCT00000114 Phase 3 Vitamin E;Vitamin A
34 Adjunct Vitamin A Therapy for Tuberculosis and HIV/AIDS Completed NCT00057434 Phase 3 multivitamin
35 Zinc, Iron and Vitamin A Supplementation for Infant Growth and Development, and the Contributing Role of Psychosocial Care Completed NCT02319499 Phase 3
36 Vitamin A Supplementation in Newborns Study Completed NCT00114868 Phase 3 Vitamin A
37 Evaluation of the Impact of Vitamin A and Zinc Supplementation on Malarial Morbidity in Ghana Completed NCT01782001 Phase 3
38 The Role of Sub-clinical Inflammation on the Iron Status of Myanmar Anaemic Adolescent Schoolgirls During Iron and Vitamin A Supplementation Completed NCT01198574 Phase 3
39 The Effect of Vitamin A With and Without Zinc and Multivitamin Supplementation on Malaria Morbidity in Ghanaian Children Completed NCT02878265 Phase 3
40 Evaluation of the Efficacy of a Combination of Micronutrients (Vitamin A, C, E, Selenium and Zinc) in Reducing the Incidence of Colorectal Metachronous Adenomas. A Double Blind, Phase III, Randomized, Placebo-controlled Trial Terminated NCT01437826 Phase 3 antioxidants;placebo
41 A Randomized Controlled Trial in Human Neonates to Determine the Effect of Vitamin A Supplementation on Immune Responses Unknown status NCT01476358 Phase 2
42 Phase 2 Study of VITAMIN A EQUIVALENCE OF PLANT CAROTENOIDS IN CHILDREN Completed NCT00680212 Phase 2
43 Prevention of HIV Shedding in Women - Trial of Vitamin A Completed NCT00053612 Phase 2 Vitamin A
44 Vitamin A Supplementation of Breast Feeding Mothers and Their Neonates at Delivery: Impact on Mother to Child Transmission of HIV During Lactation, HIV Infection Among Women During the Postpartum Year, and Infant Mortality. Completed NCT00198718 Phase 2 Vitamin A (retinyl palmitate)
45 Vitamin A Equivalence of Carotenoids From Cassava in Women Completed NCT01381276 Phase 2
46 Vitamin A Value of Spirulina Carotenoids in Humans Completed NCT00680277 Phase 1, Phase 2
47 Topical Vitamin A (All-trans Retinol) Versus Vehicle Cream in the Treatment of Aged Skin Completed NCT00272610 Phase 2 0.4% Retinol Cream
48 Randomized Trial of Vitamin A Supplementation for Extremely-Low-Birth-Weight Completed NCT01203488 Phase 1, Phase 2 Vitamin A
49 Daily Vitamin D for Sickle-cell Respiratory Complications Active, not recruiting NCT04170348 Phase 2 Daily oral vitamin D3, 3,333 IU;Bolus oral vitamin D3, 100,000 IU;Placebo oral tablet
50 The Effect of Vitamin A Supplementation on Disease Improvement of Children With Moderate to Severe COVID-19. Not yet recruiting NCT04920760 Phase 2

Search NIH Clinical Center for Keratomalacia

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Cod Liver Oil
retinol acetate
retinyl palmitate
Vitamin A
VITAMIN A (AS ACETATE & BETA CAROTENE)
VITAMIN A (AS PALMITATE & BETA CAROTENE)
VITAMIN A (NATURAL)
VITAMIN A PALMITATE (SOLUBILIZED)

Cochrane evidence based reviews: keratomalacia

Genetic Tests for Keratomalacia

Anatomical Context for Keratomalacia

Organs/tissues related to Keratomalacia:

MalaCards : Liver, Eye, Bone, Breast, Retina, Lung, Skin

Publications for Keratomalacia

Articles related to Keratomalacia:

(show top 50) (show all 27184)
# Title Authors PMID Year
1
Usual Intake of Micronutrients and Prevalence of Inadequate Intake among Chinese Adults: Data from CNHS 2015-2017. 62 41
36432400 2022
2
Vitamin A Concentration in Human Milk: A Meta-Analysis. 62 41
36432530 2022
3
Role of Vitamins and Minerals in Health and Diseases. 41
36437023 2022
4
Chapter 29: historical aspects of the major neurological vitamin deficiency disorders: overview and fat-soluble vitamin A. 53 62
19892132 2010
5
Serum retinol binding protein as an indicator of vitamin A status in cirrhotic patients with night blindness. 53 62
19568486 2008
6
Effect of vitamin A supplementation with BCG vaccine at birth on vitamin A status at 6 wk and 4 mo of age. 53 62
17921381 2007
7
HIV-1 infection alters the retinol-binding protein:transthyretin ratio even in the absence of the acute phase response. 53 62
16702331 2006
8
Retinol-binding protein, transthyretin, and C-reactive protein in extremely low birth weight (ELBW) infants. 53 62
16208398 2005
9
[Protein profile and vitamin A in children of school age in Ivory Coast]. 53 62
15951260 2005
10
Possible pathomechanisms of sudden infant death syndrome: key role of chronic hypoxia, infection/inflammation states, cytokine irregularities, and metabolic trauma in genetically predisposed infants. 53 62
15543094 2004
11
Use of serum retinol-binding protein for prediction of vitamin A deficiency: effects of HIV-1 infection, protein malnutrition, and the acute phase response. 53 62
14749226 2004
12
Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status. 53 62
14704332 2004
13
Vitamin A transport: in vitro models for the study of RBP secretion. 53 62
14585312 2003
14
Retinoid receptors and vitamin A deficiency: differential patterns of transcription during early avian development and the rapid induction of RARs by retinoic acid. 53 62
12921748 2003
15
A comparison of three vitamin A dosing regimens in extremely-low-birth-weight infants. 53 62
12838194 2003
16
In vivo studies of altered expression patterns of p53 and proliferative control genes in chronic vitamin A deficiency and hypervitaminosis. 53 62
12654005 2003
17
Biochemical indicators of vitamin A deficiency: serum retinol and serum retinol binding protein. 53 62
12221267 2002
18
Assessment of vitamin A status of preschool children in Indonesia using plasma retinol-binding protein. 53 62
12022434 2002
19
Retinol binding protein as a surrogate measure for serum retinol: studies in vitamin A-deficient children from the Republic of the Marshall Islands. 53 62
11237937 2001
20
Evaluation of plasma retinol-binding protein as a surrogate measure for plasma retinol concentrations. 53 62
10885491 2000
21
Use of the retinol-binding protein: transthyretin ratio for assessment of vitamin A status during the acute-phase response. 53 62
10953676 2000
22
MMH cells: An in vitro model for the study of retinol-binding protein secretion regulated by retinol. 53 62
10457350 1999
23
Initial retinoid requirement for early avian development coincides with retinoid receptor coexpression in the precardiac fields and induction of normal cardiovascular development. 53 62
9786419 1998
24
A low molar ratio of retinol binding protein to transthyretin indicates vitamin A deficiency during inflammation: studies in rats and a posterior analysis of vitamin A-supplemented children with measles. 53 62
9772136 1998
25
Sequential evaluation of plasma retinol-binding protein response to vitamin A administration in very-low-birth-weight neonates. 53 62
7551819 1995
26
Effect of gestational age and retinol (vitamin A) deficiency on fetal rat lung nuclear retinoic acid receptors. 53 62
8384711 1993
27
Comparison of enteral and intramuscular vitamin A supplementation in preterm infants. 53 62
1493768 1992
28
Regulation of plasma retinol binding protein secretion in human HepG2 cells. 53 62
1315290 1992
29
Prevalence of malnutrition and vitamin A deficiency in the Diourbel, Fatick, and Kaolack regions of Senegal: a controlled study. 53 62
1898583 1991
30
Test-retest reproducibility of the relative dose response for vitamin A status in Guatemalan adults: issues of diagnostic sensitivity. 53 62
2366107 1990
31
Regulation of metabolism of retinol-binding protein by vitamin A status in children with biliary atresia. 53 62
2321569 1990
32
Plasma retinol-binding protein response to vitamin A administration in infants susceptible to bronchopulmonary dysplasia. 53 62
2108233 1990
33
A simple method for analysis of vitamin A palmitate in fortified cereal products using direct solvent extraction followed by reversed-phase HPLC with UV detection. 62
36265273 2023
34
Mixing chia seeds and sprouts at different developmental stages: A cost-effective way to improve antioxidant vitamin composition. 62
36371839 2023
35
Independent and joint associations of dietary antioxidant intake with risk of post-stroke depression and all-cause mortality. 62
36372128 2023
36
Possibility to use the different sizes and colors of carrots for the production of juices - comparison of bioactive compounds, nutritional quality, pro-health properties, and sensory evaluation. 62
36071473 2023
37
Retinoic Acid-Induced Limb Duplications. 62
36272081 2023
38
Does Crop Diversity Influence Household Food Security and Women's Individual Dietary Diversity? A Cross-Sectional Study of Malawian Farmers in a Participatory Agroecology and Nutrition Project. 62
36169209 2022
39
Nutritional issues and dietary levers during gradual meat reduction - A sequential diet optimization study to achieve progressively healthier diets. 62
36306564 2022
40
UV and visible light exposure to hair leads to widespread changes in the hair lipidome. 62
35924329 2022
41
Assessment of dietary intakes and feeding practices in children aged 6-23 months in a town in the Northeast region of Argentina. 62
36374054 2022
42
Recent advances in improving intranasal allergen-specific immunotherapy; focus on delivery systems and adjuvants. 62
36257257 2022
43
Impacts of micronutrient intervention programs on effective coverage and lives saved: Modeled evidence from Cameroon. 62
36471541 2022
44
Adequacy of total usual micronutrient intakes among pregnant women in the United States by level of dairy consumption, NHANES 2003-2016. 62
35132897 2022
45
Results of the BfR MEAL Study: Highest levels of retinol found in animal livers and of β-carotene in yellow-orange and green leafy vegetables. 62
36203952 2022
46
Using Household Consumption Data to Flag Low Nutrient Access. 62
36221251 2022
47
[Essential trace elements, vitamins, and selected electrolytes in complementary medicine for cancer patients]. 62
36454272 2022
48
What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review. 62
35695158 2022
49
The impact of the COVID-19 pandemic on the diet, training habits and fitness of Masters cyclists. 62
33759633 2022
50
Peeling away from hypervitaminosis A: the importance of close monitoring in patients taking high dose vitamin A supplementation. 62
36356936 2022

Variations for Keratomalacia

Expression for Keratomalacia

Search GEO for disease gene expression data for Keratomalacia.

Pathways for Keratomalacia

Pathways related to Keratomalacia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.43 TTR RBP4 RARS1 QDPR LRAT CYP26A1
2
Show member pathways
12.37 TTR RBP4 LRAT CLPS
3
Show member pathways
12.19 TTR RHO RBP4 LRAT CLPS
4 11.43 TTR RHO RBP4 LRAT
5
Show member pathways
11.36 RARB RARA CYP26A1
6
Show member pathways
11.13 RHO LRAT
7 11.11 RARB RARA
8
Show member pathways
11.1 TTR RHO RBP4 LRAT
9 11.04 RARB RARA CYP26A1
10 10.64 RBP4 RARB RARA LRAT CYP26A1

GO Terms for Keratomalacia

Biological processes related to Keratomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retinoic acid receptor signaling pathway GO:0048384 9.73 RARB RARA
2 growth plate cartilage development GO:0003417 9.67 RARB RARA
3 response to vitamin A GO:0033189 9.63 CYP26A1 LRAT RARA
4 glandular epithelial cell development GO:0002068 9.62 RARB RARA
5 negative regulation of cartilage development GO:0061037 9.58 RARB RARA
6 ventricular cardiac muscle cell differentiation GO:0055012 9.56 RARB RARA
7 retinol metabolic process GO:0042572 9.56 TTR RBP4 LRAT CYP27C1
8 response to retinoic acid GO:0032526 9.23 RBP4 RARA LRAT CYP26A1

Molecular functions related to Keratomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monooxygenase activity GO:0004497 9.73 CYP27C1 CYP26A1 CYP20A1
2 retinol binding GO:0019841 9.62 RBP4 LRAT
3 11-cis retinal binding GO:0005502 9.46 RHO CYP27C1
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.26 CYP27C1 CYP26A1 CYP20A1
5 retinoic acid binding GO:0001972 9.23 RARA LRAT CYP27C1 CYP26A1

Sources for Keratomalacia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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