Keratomalacia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

VAD MCID: KRT002 MIFTS: 56	Keratomalacia (VAD) Categories: Endocrine diseases, Eye diseases, Metabolic diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Keratomalacia

MalaCards integrated aliases for Keratomalacia:

Name: Keratomalacia ¹¹ ¹⁹ ⁷⁵ ⁵³ ⁴³ ¹⁴ ⁷¹

Vitamin a Deficiency ¹⁹ ⁵³ ¹⁶ ⁷¹ ³¹ ³³

Retinol Deficiency ¹⁹ ⁷¹

Xerotic Keratitis ¹⁹ ⁷¹

Night Blindness ¹⁹ ⁷¹

Vitamin a Deficiency with Cornea Ulceration or Xerosis ³³

Vitamin a Deficiency with Cornea Xerosis ³³

Conjunctival Xerosis with Bitot's Spots ³³

Bitot Spots in the Young Child ³³

Hypovitaminosis a ³³

Bitot Spots ³³

Vitamin a ⁴¹

Vad ⁴⁷

Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases
Anatomical: Endocrine diseases Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Endocrine, nutritional and metabolic diseases

Other nutritional deficiencies

Vitamin A deficiency

Vitamin A deficiency with Bitot spot and conjunctival xerosis

Vitamin A deficiency with conjunctival xerosis

Vitamin A deficiency with corneal ulceration and xerosis

Vitamin A deficiency with corneal xerosis

Vitamin A deficiency with keratomalacia

Vitamin A deficiency with night blindness

Vitamin A deficiency with xerophthalmic scars of cornea

Vitamin A deficiency, unspecified

ICD11: ³³

Endocrine, nutritional or metabolic diseases

Nutritional disorders

Undernutrition

Vitamin A deficiency

Vitamin A deficiency with conjunctival xerosis

Vitamin A deficiency with conjunctival xerosis and Bitot's spots

Vitamin A deficiency with corneal ulceration or keratomalacia

Vitamin A deficiency with corneal xerosis

Vitamin A deficiency with night blindness

Vitamin A deficiency with other specified manifestations

Vitamin A deficiency with xerophthalmic scars of cornea or blindness

Vitamin A deficiency, unspecified

External Ids:

Disease Ontology ¹¹ DOID:11267

ICD9CM ³⁴ 371.45

MeSH ⁴³ C536156

SNOMED-CT ⁶⁸ 85149007

ICD10 ³¹ E50 E50.0 E50.1 more

EFO ¹⁶ EFO_1001237

ICD11 ³³ 1040403412 1252924203 1307433024 more

UMLS ⁷¹ C0028077 C0042842 C0152455 more

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Summaries for Keratomalacia

MedlinePlus: ⁴¹ Vitamins are substances that your body needs to grow and develop normally. Vitamin A plays a role in your: Vision Bone growth Reproduction Cell functions Immune system Vitamin A is an antioxidant. It can come from plant or animal sources. Plant sources include colorful fruits and vegetables. Animal sources include liver and whole milk. Vitamin A is also added to foods like cereals. Vegetarians, young children, and alcoholics may need extra Vitamin A. You might also need more if you have certain conditions, such as liver diseases, cystic fibrosis, and Crohn's disease. Check with your health care provider to see if you need to take vitamin A supplements. NIH: National Institutes of Health Office of Dietary Supplements

MalaCards based summary: Keratomalacia, also known as vitamin a deficiency, is related to leber congenital amaurosis 2 and xerophthalmia, and has symptoms including photophobia, amaurosis fugax and metamorphopsia. An important gene associated with Keratomalacia is RBP4 (Retinol Binding Protein 4), and among its related pathways/superpathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. The drugs BCG vaccine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and digestive/alimentary

GARD: ¹⁹ dryness with ulceration and perforation of the cornea, with absence of inflammatory reactions, occurring in cachectic children; results from severe vitamin A deficiency.

Wikipedia: ⁷⁵ Keratomalacia is an eye disorder that results from vitamin A deficiency. Vitamin A is required to... more...

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Related Diseases for Keratomalacia

Diseases related to Keratomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1229)

#	Related Disease	Score	Top Affiliating Genes
1	leber congenital amaurosis 2	31.7	RHO LRAT
2	xerophthalmia	31.7	TTR RHO RARS1
3	carotenemia	31.6	TTR CYP26A1
4	night blindness	30.2	RHO RBP4 LRAT
5	hypervitaminosis a	29.9	TTR RBP4 RARS1 LRAT CYP26A1
6	coloboma, ocular, autosomal dominant	29.9	RBP4 RARB
7	intracranial hypertension, idiopathic	29.8	RBP4 RARA
8	stargardt disease	29.8	RHO RBP4 LRAT
9	diaphragmatic hernia, congenital	29.8	RARB LRAT CYP26A1
10	acute promyelocytic leukemia	29.8	RARS1 RARB RARA CYP26A1
11	amyloidosis, hereditary, transthyretin-related	29.7	TTR RBP4
12	protein-energy malnutrition	29.6	TTR RBP4
13	coloboma of macula	29.6	RHO RBP4 RARB
14	squamous cell carcinoma, head and neck	29.6	RARS1 RARB RARA CYP26A1
15	teratocarcinoma	29.3	RARS1 RARB RARA
16	microphthalmia, syndromic 9	29.2	RBP4 RARS1 RARB LRAT CYP26A1
17	embryonal carcinoma	29.1	RARS1 RARB RARA CYP26A1
18	x-linked congenital stationary night blindness	11.9
19	congenital stationary night blindness	11.9
20	night blindness, congenital stationary, type 1b	11.8
21	night blindness, congenital stationary, type 1h	11.8
22	night blindness, congenital stationary, type 1e	11.8
23	night blindness, congenital stationary, type 2a	11.8
24	night blindness, congenital stationary, type 1d	11.8
25	night blindness, congenital stationary, autosomal dominant 2	11.8
26	night blindness, congenital stationary, autosomal dominant 3	11.8
27	night blindness, congenital stationary, type 1f	11.8
28	night blindness, congenital stationary, type 1c	11.8
29	night blindness, congenital stationary, autosomal dominant 1	11.8
30	night blindness, congenital stationary, type1i	11.7
31	autosomal recessive congenital stationary night blindness	11.7
32	cone-rod synaptic disorder, congenital nonprogressive	11.7
33	night blindness, congenital stationary, type 1g	11.7
34	hypercarotenemia and vitamin a deficiency, autosomal dominant	11.7
35	oguchi disease 2	11.7
36	oguchi disease 1	11.6
37	autosomal dominant congenital stationary night blindness	11.6
38	retinal cone dystrophy 3b	11.6
39	oguchi disease	11.6
40	hereditary hypercarotenemia and vitamin a deficiency	11.6
41	retinal cone dystrophy 3a	11.6
42	night blindness-skeletal anomalies-dysmorphism syndrome	11.5
43	chondroectodermal dysplasia with night blindness	11.4
44	fundus albipunctatus	11.4
45	acquired night blindness	11.3
46	choroideremia	11.3
47	enhanced s-cone syndrome	11.3
48	cone-rod dystrophy 2	11.3
49	late-onset retinal degeneration	11.3
50	retinitis pigmentosa	11.3

Graphical network of the top 20 diseases related to Keratomalacia:

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Symptoms & Phenotypes for Keratomalacia

UMLS symptoms related to Keratomalacia:

photophobia; amaurosis fugax; metamorphopsia; other specified visual disturbances; visual disturbance; subjective visual disturbance, unspecified; visual manifestations

GenomeRNAi Phenotypes related to Keratomalacia according to GeneCards Suite gene sharing:

²⁵ (show all 24)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-12	9.77	CYP27C1
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	9.77	RARA
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-137	9.77	CYP26A1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-148	9.77	CYP27C1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	9.77	CYP27C1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-160	9.77	QDPR
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	9.77	RARA
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-180	9.77	CYP20A1 CYP26A1 CYP27C1 QDPR RARA
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-184	9.77	RARA
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	9.77	QDPR
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-200	9.77	CYP20A1
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-203	9.77	QDPR
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-204	9.77	CYP27C1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	9.77	CYP26A1
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-29	9.77	CYP26A1
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-36	9.77	CYP27C1
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-40	9.77	CYP27C1
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	9.77	CYP27C1
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	9.77	CYP20A1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	9.77	CYP27C1
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-60	9.77	CYP27C1
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-68	9.77	CYP27C1
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-77	9.77	CYP27C1
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-83	9.77	CYP20A1

MGI Mouse Phenotypes related to Keratomalacia:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.17	CLPS CYP26A1 EN2 RARA RARB RBP4

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Drugs & Therapeutics for Keratomalacia

Drugs for Keratomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 113)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

BCG vaccine

Approved, Investigational

Phase 4

Racepinephrine

Approved, Vet_approved

Phase 4

51-43-4, 329-65-7

838 5816

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

4894 5755

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

1875

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

4159 6741

Albendazole

Approved, Vet_approved

Phase 4

54965-21-8

2082

Methylphenidate

Approved, Investigational

Phase 4

113-45-1

4158

Vitamin A

Approved, Nutraceutical, Vet_approved

Phase 4

22737-96-8, 68-26-8

5280382 445354

Cholecalciferol

Approved, Nutraceutical, Vet_approved

Phase 4

67-97-0, 1406-16-2

5280795 10883523

Ergocalciferol

Approved, Nutraceutical

Phase 4

50-14-6

5280793

Isotretinoin

Approved, Investigational, Nutraceutical

Phase 4

302-79-4, 4759-48-2

5538 444795 5282379

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

4897

polysaccharide-K

Phase 4

Anti-Infective Agents

Phase 4

Epinephryl borate

Phase 4

Antineoplastic Agents, Hormonal

Phase 4

Neuroprotective Agents

Phase 4

Hormone Antagonists

Phase 4

Antiemetics

Phase 4

glucocorticoids

Phase 4

Anti-Inflammatory Agents

Phase 4

Methylprednisolone Acetate

Phase 4

584547

Gastrointestinal Agents

Phase 4

Antimitotic Agents

Phase 4

Antiprotozoal Agents

Phase 4

Anthelmintics

Phase 4

Antiparasitic Agents

Phase 4

Tubulin Modulators

Phase 4

Vitamins

Phase 4

Trace Elements

Phase 4

Micronutrients

Phase 4

Retinol palmitate

Phase 4

Calciferol

Phase 4

Dermatologic Agents

Phase 4

Calcium, Dietary

Phase 4

Vitamin D2

Phase 4

3249

Hormones

Phase 4

Ergocalciferols

Phase 4

Keratolytic Agents

Phase 4

Vaccines

Phase 4

Calcium

Nutraceutical

Phase 4

7440-70-2

271

Zinc cation

Approved, Experimental, Investigational

Phase 3

7440-66-6, 23713-49-7

32051

Zinc sulfate

Approved, Investigational

Phase 3

7733-02-0

Orange

Approved

Phase 3

Levoleucovorin

Approved, Experimental, Investigational

Phase 3

68538-85-2, 58-05-9, 73951-54-9

149436 6006

Ferrous fumarate

Approved

Phase 3

141-01-5

Tocopherol

Approved, Investigational

Phase 3

1406-66-2

Selenium

Approved, Investigational, Vet_approved

Phase 3

7783-07-5, 7782-49-2

533

Interventional clinical trials:

(show top 50) (show all 150)

#	Name	Status	NCT ID	Phase	Drugs
1	Impact of Vitamin A Supplementation on RAR Gene Expression in PBMC Cells in Multiple Sclerotic Patients	Unknown status	NCT01705457	Phase 4	Dietary Supplement: vitamin A;placebo
2	Randomised Trial of Vitamin A Supplementation Given With Routine Childhood Vaccines at National Immunisation Days	Unknown status	NCT00168623	Phase 4	Vitamin A
3	Should Infants Receive High-dose Vitamin A Supplementation With BCG Vaccine at Birth in Developing Countries? Randomized Prospective Studies in Guinea-Bissau	Unknown status	NCT00168610	Phase 4	Vitamin A
4	The Study of the Effects of Vitamin A Supplementation on Immune System and Th1/Th2 Balance in Patients With Atherosclerosis	Unknown status	NCT00963222	Phase 4	vitamin A;placebo
5	The Effect of a Nutrient Fortified Oat Drink on Iron, Zinc, Vitamin A, and Vitamin C Status Among Filipino Children	Unknown status	NCT01418898	Phase 4
6	The Impact of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by CD4+ T Lymphocyte in Multiple Sclerosis Patients	Unknown status	NCT01407211	Phase 4
7	The Effect of Vitamin A Supplementation on CD4+ T-cell Secretion in Obese Individuals	Unknown status	NCT01405352	Phase 4
8	The Effect of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by T CD4+ Lymphocyte in Atherosclerotic Patients	Unknown status	NCT01414972	Phase 4	Vitamin A;placebo
9	Impact of Vitamin A Supplementation on Disease Activity and Progression in Multiple Sclerotic (MS) Patients	Unknown status	NCT01417273	Phase 4	Drug: placebo
10	Adrenal Cortical Function and Vitamin A Deficiency in Sepsis, Severe Sepsis and Septic Shock: Prospective Randomized, Double Blind Placebo Controlled Clinical Trials	Completed	NCT03152474	Phase 4	Solumedrol 20mg;Vitamin A 100,000 IU
11	Does Additional Vitamin A Supplementation Improve Retinal Function and Conjunctival Health in Very Low Birthweight Infants?	Completed	NCT00417404	Phase 4	Aquasol A;aquasol A
12	The Impact of Different Doses of Vitamin A Supplementation on Male and Female Childhood Morbidity and Mortality	Completed	NCT00168636	Phase 4	Vitamin A
13	Should Infants Receive High-dose Vitamin A Supplementation With BCG Vaccine at Birth in Developing Countries?	Completed	NCT00168597	Phase 4	Vitamin A
14	Randomised Study of the Impact of Different Doses of Vitamin A on Childhood Morbidity and Mortality	Completed	NCT00168584	Phase 4	Vitamin A
15	Vitamin A and Zinc: Prevention of Pneumonia (VAZPOP) Study	Completed	NCT00228254	Phase 4	Zinc (12.5 mg/day);vitamin A 10,000 IU per week
16	Deworming and Enhanced Vitamin A Supplementation DEVTA Project	Completed	NCT00222547	Phase 4	Vitamin A;Albendazole
17	The Study of the Effects of Vitamin A Supplementation on Immune System and Th1/Th2 Balance in Patients With Multiple Sclerosis	Completed	NCT01225289	Phase 4	Placebo
18	Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD:A Randomized, Double Blind, Placebo-controlled, Multicentric Trial.	Recruiting	NCT04284059	Phase 4	Placebos
19	Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	Not yet recruiting	NCT05002530	Phase 4	Aerosolized 13 cis retinoic acid plus Vitamin D;Aerosolized All trans retinoic acid plus Vitamin D
20	Evaluation of the Impact on Mortality and Morbidity of the WHO Recommended Vitamin A Supplementation at First Immunisation Contact After 6 Months of Age	Terminated	NCT00514891	Phase 4
21	Effects of Fat-soluble Vitamins Supplementation in Early Life on Common Complications and Neural Development in Very Low Birth Weight Infants	Unknown status	NCT03876704	Phase 3	High dose of fat-Soluble Vitamin;Conventional dose of fat-Soluble Vitamin
22	Moringa Oleifera (Drumstick Leaves) for Improving Haemoglobin, Vitamin A Status and Underweight Among Adolescent Girls in Rural Bangladesh: A Quasi-experimental Study	Unknown status	NCT04156321	Phase 3
23	Intratracheal Vitamin A Administration With Surfactant for Newborn Respiratory Distress Syndrome	Unknown status	NCT01265589	Phase 3	surfactant;surfactant+vitamin A
24	Stopping Postpartum Vitamin A Supplementation: Are we Missing Concealed Benefit?	Completed	NCT02043223	Phase 2, Phase 3
25	Impact of Supplementation With Dual Megadose of Vitamin A in the Post-partum About Vitamin A Levels in Breast Milk, Serum Levels of Vitamin A and Iron in the Binomial Mother-son and Growth and Morbidity of Children Under 6 Months	Completed	NCT00742937	Phase 2, Phase 3
26	Efficacy of β-carotene Biofortified Maize in Improving Vitamin A Status and Reducing the Prevalence of Vitamin A Deficiency Among Children in Rural Zambia	Completed	NCT01695148	Phase 3
27	A Randomized Community Trial of Newborn Vitamin A Supplementation to Reduce Infant Mortality in Rural Bangladesh	Completed	NCT00128557	Phase 3
28	Randomised Double-blind Placebo-controlled Trial to Evaluate the Impact of Vitamin A on Maternal Mortality in Ghana	Completed	NCT00211341	Phase 3
29	Impact of Maternal Vitamin A or Beta-Carotene Supplementation on Maternal and Infant Mortality in Bangladesh	Completed	NCT00198822	Phase 3
30	Efficacy of Biofortified Maize to Improve Maternal and Infant Vitamin A Status	Completed	NCT02804490	Phase 3
31	Effect of Vitamin A in the Treatment of Sepsis and Necrotizing Enterocolitis in Hospitalized Neonates	Completed	NCT00707785	Phase 3
32	To Assess the Effectiveness of Six-Monthly Deworming With Vitamin A Administration on Growth in 1-5 Year Old Children in the Urban Slums of Lucknow	Completed	NCT00396500	Phase 3	Albendazole (400 mg) and/or Vitamin a
33	Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa	Completed	NCT00000114	Phase 3	Vitamin E;Vitamin A
34	Adjunct Vitamin A Therapy for Tuberculosis and HIV/AIDS	Completed	NCT00057434	Phase 3	multivitamin
35	Zinc, Iron and Vitamin A Supplementation for Infant Growth and Development, and the Contributing Role of Psychosocial Care	Completed	NCT02319499	Phase 3
36	Vitamin A Supplementation in Newborns Study	Completed	NCT00114868	Phase 3	Vitamin A
37	Evaluation of the Impact of Vitamin A and Zinc Supplementation on Malarial Morbidity in Ghana	Completed	NCT01782001	Phase 3
38	The Role of Sub-clinical Inflammation on the Iron Status of Myanmar Anaemic Adolescent Schoolgirls During Iron and Vitamin A Supplementation	Completed	NCT01198574	Phase 3
39	The Effect of Vitamin A With and Without Zinc and Multivitamin Supplementation on Malaria Morbidity in Ghanaian Children	Completed	NCT02878265	Phase 3
40	Evaluation of the Efficacy of a Combination of Micronutrients (Vitamin A, C, E, Selenium and Zinc) in Reducing the Incidence of Colorectal Metachronous Adenomas. A Double Blind, Phase III, Randomized, Placebo-controlled Trial	Terminated	NCT01437826	Phase 3	antioxidants;placebo
41	A Randomized Controlled Trial in Human Neonates to Determine the Effect of Vitamin A Supplementation on Immune Responses	Unknown status	NCT01476358	Phase 2
42	Phase 2 Study of VITAMIN A EQUIVALENCE OF PLANT CAROTENOIDS IN CHILDREN	Completed	NCT00680212	Phase 2
43	Prevention of HIV Shedding in Women - Trial of Vitamin A	Completed	NCT00053612	Phase 2	Vitamin A
44	Vitamin A Supplementation of Breast Feeding Mothers and Their Neonates at Delivery: Impact on Mother to Child Transmission of HIV During Lactation, HIV Infection Among Women During the Postpartum Year, and Infant Mortality.	Completed	NCT00198718	Phase 2	Vitamin A (retinyl palmitate)
45	Vitamin A Equivalence of Carotenoids From Cassava in Women	Completed	NCT01381276	Phase 2
46	Vitamin A Value of Spirulina Carotenoids in Humans	Completed	NCT00680277	Phase 1, Phase 2
47	Topical Vitamin A (All-trans Retinol) Versus Vehicle Cream in the Treatment of Aged Skin	Completed	NCT00272610	Phase 2	0.4% Retinol Cream
48	Randomized Trial of Vitamin A Supplementation for Extremely-Low-Birth-Weight	Completed	NCT01203488	Phase 1, Phase 2	Vitamin A
49	Daily Vitamin D for Sickle-cell Respiratory Complications	Active, not recruiting	NCT04170348	Phase 2	Daily oral vitamin D3, 3,333 IU;Bolus oral vitamin D3, 100,000 IU;Placebo oral tablet
50	The Effect of Vitamin A Supplementation on Disease Improvement of Children With Moderate to Severe COVID-19.	Not yet recruiting	NCT04920760	Phase 2

Search NIH Clinical Center for Keratomalacia

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Cod Liver Oil

retinol acetate

retinyl palmitate

Vitamin A

VITAMIN A (AS ACETATE & BETA CAROTENE)

VITAMIN A (AS PALMITATE & BETA CAROTENE)

VITAMIN A (NATURAL)

VITAMIN A PALMITATE (SOLUBILIZED)

Cochrane evidence based reviews: keratomalacia

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Genetic Tests for Keratomalacia

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Anatomical Context for Keratomalacia

Organs/tissues related to Keratomalacia:

MalaCards : Liver, Eye, Bone, Breast, Retina, Lung, Skin

Sources

Publications for Keratomalacia

Articles related to Keratomalacia:

(show top 50) (show all 27184)

#	Title	Authors	PMID	Year
1	Usual Intake of Micronutrients and Prevalence of Inadequate Intake among Chinese Adults: Data from CNHS 2015-2017. ⁶² ⁴¹	Huang K...Zhao L	36432400	2022
2	Vitamin A Concentration in Human Milk: A Meta-Analysis. ⁶² ⁴¹	Zhang H...Lai J	36432530	2022
3	Role of Vitamins and Minerals in Health and Diseases. ⁴¹	Tanaka K...Kambe T	36437023	2022
4	Chapter 29: historical aspects of the major neurological vitamin deficiency disorders: overview and fat-soluble vitamin A. ⁵³ ⁶²	Lanska DJ	19892132	2010
5	Serum retinol binding protein as an indicator of vitamin A status in cirrhotic patients with night blindness. ⁵³ ⁶²	Mahmood K...Qazmi W	19568486	2008
6	Effect of vitamin A supplementation with BCG vaccine at birth on vitamin A status at 6 wk and 4 mo of age. ⁵³ ⁶²	Fisker AB...Benn CS	17921381	2007
7	HIV-1 infection alters the retinol-binding protein:transthyretin ratio even in the absence of the acute phase response. ⁵³ ⁶²	Baeten JM...McClelland RS	16702331	2006
8	Retinol-binding protein, transthyretin, and C-reactive protein in extremely low birth weight (ELBW) infants. ⁵³ ⁶²	Ambalavanan N...Carlo WA	16208398	2005
9	[Protein profile and vitamin A in children of school age in Ivory Coast]. ⁵³ ⁶²	Yapi HF...Monnet D	15951260	2005
10	Possible pathomechanisms of sudden infant death syndrome: key role of chronic hypoxia, infection/inflammation states, cytokine irregularities, and metabolic trauma in genetically predisposed infants. ⁵³ ⁶²	Prandota J	15543094	2004
11	Use of serum retinol-binding protein for prediction of vitamin A deficiency: effects of HIV-1 infection, protein malnutrition, and the acute phase response. ⁵³ ⁶²	Baeten JM...McClelland RS	14749226	2004
12	Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status. ⁵³ ⁶²	Ross AC...Zolfaghari R	14704332	2004
13	Vitamin A transport: in vitro models for the study of RBP secretion. ⁵³ ⁶²	Bellovino D...Gaetani S	14585312	2003
14	Retinoid receptors and vitamin A deficiency: differential patterns of transcription during early avian development and the rapid induction of RARs by retinoic acid. ⁵³ ⁶²	Cui J...Zile MH	12921748	2003
15	A comparison of three vitamin A dosing regimens in extremely-low-birth-weight infants. ⁵³ ⁶²	Ambalavanan N...Carlo WA	12838194	2003
16	In vivo studies of altered expression patterns of p53 and proliferative control genes in chronic vitamin A deficiency and hypervitaminosis. ⁵³ ⁶²	Borras E...Torres L	12654005	2003
17	Biochemical indicators of vitamin A deficiency: serum retinol and serum retinol binding protein. ⁵³ ⁶²	de Pee S...Dary O	12221267	2002
18	Assessment of vitamin A status of preschool children in Indonesia using plasma retinol-binding protein. ⁵³ ⁶²	Semba RD...Muhilal	12022434	2002
19	Retinol binding protein as a surrogate measure for serum retinol: studies in vitamin A-deficient children from the Republic of the Marshall Islands. ⁵³ ⁶²	Gamble MV...Blaner WS	11237937	2001
20	Evaluation of plasma retinol-binding protein as a surrogate measure for plasma retinol concentrations. ⁵³ ⁶²	Almekinder J...Semba RD	10885491	2000
21	Use of the retinol-binding protein: transthyretin ratio for assessment of vitamin A status during the acute-phase response. ⁵³ ⁶²	Filteau SM...Gamble M	10953676	2000
22	MMH cells: An in vitro model for the study of retinol-binding protein secretion regulated by retinol. ⁵³ ⁶²	Bellovino D...Gaetani S	10457350	1999
23	Initial retinoid requirement for early avian development coincides with retinoid receptor coexpression in the precardiac fields and induction of normal cardiovascular development. ⁵³ ⁶²	Kostetskii I...Zile M	9786419	1998
24	A low molar ratio of retinol binding protein to transthyretin indicates vitamin A deficiency during inflammation: studies in rats and a posterior analysis of vitamin A-supplemented children with measles. ⁵³ ⁶²	Rosales FJ...Ross AC	9772136	1998
25	Sequential evaluation of plasma retinol-binding protein response to vitamin A administration in very-low-birth-weight neonates. ⁵³ ⁶²	Shenai JP...Chytil F	7551819	1995
26	Effect of gestational age and retinol (vitamin A) deficiency on fetal rat lung nuclear retinoic acid receptors. ⁵³ ⁶²	McMenamy KR...Zachman RD	8384711	1993
27	Comparison of enteral and intramuscular vitamin A supplementation in preterm infants. ⁵³ ⁶²	Landman J...Sacks R	1493768	1992
28	Regulation of plasma retinol binding protein secretion in human HepG2 cells. ⁵³ ⁶²	Tosetti F...Vidali G	1315290	1992
29	Prevalence of malnutrition and vitamin A deficiency in the Diourbel, Fatick, and Kaolack regions of Senegal: a controlled study. ⁵³ ⁶²	Carlier C...Amedee-Manesme O	1898583	1991
30	Test-retest reproducibility of the relative dose response for vitamin A status in Guatemalan adults: issues of diagnostic sensitivity. ⁵³ ⁶²	Solomons NW...Russell RM	2366107	1990
31	Regulation of metabolism of retinol-binding protein by vitamin A status in children with biliary atresia. ⁵³ ⁶²	Mourey MS...Amedee-Manesme O	2321569	1990
32	Plasma retinol-binding protein response to vitamin A administration in infants susceptible to bronchopulmonary dysplasia. ⁵³ ⁶²	Shenai JP...Chytil F	2108233	1990
33	A simple method for analysis of vitamin A palmitate in fortified cereal products using direct solvent extraction followed by reversed-phase HPLC with UV detection. ⁶²	Van Wayenbergh E...Courtin CM	36265273	2023
34	Mixing chia seeds and sprouts at different developmental stages: A cost-effective way to improve antioxidant vitamin composition. ⁶²	Bermejo NF...Munne-Bosch S	36371839	2023
35	Independent and joint associations of dietary antioxidant intake with risk of post-stroke depression and all-cause mortality. ⁶²	Xu Q...Zhang J	36372128	2023
36	Possibility to use the different sizes and colors of carrots for the production of juices - comparison of bioactive compounds, nutritional quality, pro-health properties, and sensory evaluation. ⁶²	Yusuf EH...Nowicka P	36071473	2023
37	Retinoic Acid-Induced Limb Duplications. ⁶²	Maden M...Polvadore T	36272081	2023
38	Does Crop Diversity Influence Household Food Security and Women's Individual Dietary Diversity? A Cross-Sectional Study of Malawian Farmers in a Participatory Agroecology and Nutrition Project. ⁶²	Owoputi I...Kerr RB	36169209	2022
39	Nutritional issues and dietary levers during gradual meat reduction - A sequential diet optimization study to achieve progressively healthier diets. ⁶²	Dussiot A...Mariotti F	36306564	2022
40	UV and visible light exposure to hair leads to widespread changes in the hair lipidome. ⁶²	Ross AB...Willicut RJ	35924329	2022
41	Assessment of dietary intakes and feeding practices in children aged 6-23 months in a town in the Northeast region of Argentina. ⁶²	Spipp JP...Albrecht C	36374054	2022
42	Recent advances in improving intranasal allergen-specific immunotherapy; focus on delivery systems and adjuvants. ⁶²	Sadeghi M...Dehnavi S	36257257	2022
43	Impacts of micronutrient intervention programs on effective coverage and lives saved: Modeled evidence from Cameroon. ⁶²	Vosti SA...Engle-Stone R	36471541	2022
44	Adequacy of total usual micronutrient intakes among pregnant women in the United States by level of dairy consumption, NHANES 2003-2016. ⁶²	Higgins KA...Murphy MM	35132897	2022
45	Results of the BfR MEAL Study: Highest levels of retinol found in animal livers and of β-carotene in yellow-orange and green leafy vegetables. ⁶²	Schendel S...Sarvan I	36203952	2022
46	Using Household Consumption Data to Flag Low Nutrient Access. ⁶²	Mathiassen A...Sandstrom S	36221251	2022
47	[Essential trace elements, vitamins, and selected electrolytes in complementary medicine for cancer patients]. ⁶²	Buntzel J...Micke O	36454272	2022
48	What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review. ⁶²	Pameijer EM...van Leeuwen R	35695158	2022
49	The impact of the COVID-19 pandemic on the diet, training habits and fitness of Masters cyclists. ⁶²	Shaw KA...Chilibeck PD	33759633	2022
50	Peeling away from hypervitaminosis A: the importance of close monitoring in patients taking high dose vitamin A supplementation. ⁶²	Eldredge JA...McGrath KH	36356936	2022

Sources

Genes for Keratomalacia

Genes related to Keratomalacia (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	RBP4	Retinol Binding Protein 4	Protein Coding	14.39	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	14749226 19568486 16702331 (more) 1493768 16208398 10885491 2321569 2108233 11237937 12838194 7551819 2366107 12022434 10953676 10457350 12221267 17921381 1315290 14585312
2	TTR	Transthyretin	Protein Coding	12.31	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16208398 16702331 1898583 (more) 9772136 10953676 15951260 2366107
3	RHO	Rhodopsin	Protein Coding	12.12	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19892132
4	CYP26A1	Cytochrome P450 Family 26 Subfamily A Member 1	Protein Coding	10.55	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	14704332
5	RARS1	Arginyl-TRNA Synthetase 1	Protein Coding	9.92	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	12921748
6	RARA	Retinoic Acid Receptor Alpha	Protein Coding	6.41	Novoseek inferred ⁵³	9786419 8384711 12654005
7	LRAT	Lecithin Retinol Acyltransferase	Protein Coding	5.73	Novoseek inferred ⁵³	14704332
8	RARB	Retinoic Acid Receptor Beta	Protein Coding	5.64	Novoseek inferred ⁵³	9786419
9	QDPR	Quinoid Dihydropteridine Reductase	Protein Coding	4.79	DISEASES inferred ¹⁴
10	CYP27C1	Cytochrome P450 Family 27 Subfamily C Member 1	Protein Coding	4.61	DISEASES inferred ¹⁴
11	CYP20A1	Cytochrome P450 Family 20 Subfamily A Member 1	Protein Coding	4.53	DISEASES inferred ¹⁴
12	EN2	Engrailed Homeobox 2	Protein Coding	4.41	DISEASES inferred ¹⁴
13	TSC22D2	TSC22 Domain Family Member 2	Protein Coding	4.4	DISEASES inferred ¹⁴
14	CLPS	Colipase	Protein Coding	4.27	DISEASES inferred ¹⁴

Sources

Variations for Keratomalacia

Sources

Expression for Keratomalacia

Search GEO for disease gene expression data for Keratomalacia.

Sources

Pathways for Keratomalacia

Pathways related to Keratomalacia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁶ Show member pathways Metabolism of lipids ⁶⁶	13.43	TTR RBP4 RARS1 QDPR LRAT CYP26A1
2	Metabolism of water-soluble vitamins and cofactors ⁶⁶ Show member pathways Biotin metabolism, including IMDs ⁷⁴ Biotin transport and metabolism ⁶⁶ Coenzyme A biosynthesis ⁶⁶ Defective BTD causes biotidinase deficiency ⁶⁶ Defective HLCS causes multiple carboxylase deficiency ⁶⁶ Defects in biotin (Btn) metabolism ⁶⁶ Metabolism of cofactors ⁶⁶ Metabolism of folate and pterines ⁶⁶ Metabolism of vitamins and cofactors ⁶⁶ molybdenum cofactor biosynthesis ⁶¹ Molybdenum cofactor biosynthesis ⁶⁶ Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation ⁶⁶ thiamin salvage III ⁶¹ Ubiquinol biosynthesis ⁶⁶ Vitamin B1 (thiamin) metabolism ⁶⁶ Vitamin B2 (riboflavin) metabolism ⁶⁶ Vitamin B5 (pantothenate) metabolism ⁶⁶ Vitamin C (ascorbate) metabolism ⁶⁶ Vitamins B6 activation to pyridoxal phosphate ⁶⁶	12.37	TTR RBP4 LRAT CLPS
3	Visual phototransduction ⁶⁶ Show member pathways Activation of the phototransduction cascade ⁶⁶ Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) ⁶⁶ Inactivation, recovery and regulation of the phototransduction cascade ⁶⁶ menaquinol-4 biosynthesis II ⁶¹ Metabolism of fat-soluble vitamins ⁶⁶ Metabolism of vitamin K ⁶⁶ Retinoid metabolism and transport ⁶⁶ retinol biosynthesis ⁶¹ The phototransduction cascade ⁶⁶ The retinoid cycle in cones (daylight vision) ⁶⁶ the visual cycle I (vertebrates) ⁶¹ Visual signal transduction: Rods ⁶¹ Vitamin E ⁶⁶	12.19	TTR RHO RBP4 LRAT CLPS
4	Visual Cycle in Retinal Rods ⁶⁴	11.43	TTR RHO RBP4 LRAT
5	Signaling by Retinoic Acid ⁶⁶ Show member pathways RA biosynthesis pathway ⁶⁶	11.36	RARB RARA CYP26A1
6	Retinol metabolism (TR) ²² Show member pathways Ifosfamide Pathway, Pharmacokinetics ⁶⁰	11.13	RHO LRAT
7	Development of ureteric collection system ⁷⁴	11.11	RARB RARA
8	Diseases of the neuronal system ⁶⁶ Show member pathways Biosynthesis of A2E, implicated in retinal degradation ⁶⁶ Diseases associated with visual transduction ⁶⁶ Retinoid cycle disease events ⁶⁶ The canonical retinoid cycle in rods (twilight vision) ⁶⁶	11.1	TTR RHO RBP4 LRAT
9	Nuclear receptors in lipid metabolism and toxicity ⁷⁴	11.04	RARB RARA CYP26A1
10	Vitamin A and carotenoid metabolism ⁷⁴	10.64	RBP4 RARB RARA LRAT CYP26A1

Sources

GO Terms for Keratomalacia

Biological processes related to Keratomalacia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	retinoic acid receptor signaling pathway	GO:0048384	9.73	RARB RARA
2	growth plate cartilage development	GO:0003417	9.67	RARB RARA
3	response to vitamin A	GO:0033189	9.63	CYP26A1 LRAT RARA
4	glandular epithelial cell development	GO:0002068	9.62	RARB RARA
5	negative regulation of cartilage development	GO:0061037	9.58	RARB RARA
6	ventricular cardiac muscle cell differentiation	GO:0055012	9.56	RARB RARA
7	retinol metabolic process	GO:0042572	9.56	TTR RBP4 LRAT CYP27C1
8	response to retinoic acid	GO:0032526	9.23	RBP4 RARA LRAT CYP26A1

Molecular functions related to Keratomalacia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	monooxygenase activity	GO:0004497	9.73	CYP27C1 CYP26A1 CYP20A1
2	retinol binding	GO:0019841	9.62	RBP4 LRAT
3	11-cis retinal binding	GO:0005502	9.46	RHO CYP27C1
4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	9.26	CYP27C1 CYP26A1 CYP20A1
5	retinoic acid binding	GO:0001972	9.23	RARA LRAT CYP27C1 CYP26A1