Aliases & Classifications for Keratopathy

MalaCards integrated aliases for Keratopathy:

Name: Keratopathy 39 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2283
NCIt 51 C27012
UMLS 74 C0235270

Summaries for Keratopathy

MalaCards based summary : Keratopathy is related to bullous keratopathy and limbal stem cell deficiency. An important gene associated with Keratopathy is PAX6 (Paired Box 6), and among its related pathways/superpathways are Phospholipase-C Pathway and G-protein signaling RAC1 in cellular process. The drugs Pharmaceutical Solutions and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and lung, and related phenotypes are homeostasis/metabolism and behavior/neurological

Related Diseases for Keratopathy

Diseases related to Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 bullous keratopathy 33.5 BMP4 FBN1 NID1 TGFB2 TNC
2 limbal stem cell deficiency 29.7 KRT12 VCAM1
3 microvascular complications of diabetes 5 28.9 AKR1B1 IGF1 VCAM1
4 thygeson superficial punctate keratopathy 12.3
5 neurotrophic keratopathy 12.2
6 climatic droplet keratopathy 12.2
7 corneal dystrophy, band-shaped 11.8
8 schnyder corneal dystrophy 11.1
9 palmoplantar carcinoma, multiple self-healing 11.1
10 corneal degeneration, ribbonlike, with deafness 11.1
11 aniridia 1 10.4
12 cataract 10.3
13 keratitis, hereditary 10.3
14 myeloma, multiple 10.2
15 stiff skin syndrome 10.2 FBN1 TGFB2
16 lagophthalmos 10.2
17 warthin tumor 10.2 TGFB2 VCAM1
18 monoclonal gammopathy of uncertain significance 10.2
19 autoimmune addison disease 10.2 AIRE NLRP1
20 keratoconus 10.1
21 corneal dystrophy, posterior polymorphous, 3 10.1 BMP4 TGFB2
22 aortic disease 10.1 FBN1 NLRP1 TGFB2
23 char syndrome 10.1 BMP4 FBN1
24 corneal dystrophy, fuchs endothelial, 1 10.1
25 fuchs' endothelial dystrophy 10.1
26 uveitis 10.1
27 arthritis 10.1
28 ptosis 10.1
29 corneal neovascularization 10.1
30 herpes zoster 10.1
31 amyloidosis 10.1
32 loeys-dietz syndrome 3 10.0 FBN1 TGFB2
33 rheumatoid arthritis 10.0
34 alkaptonuria 10.0
35 fabry disease 10.0
36 herpes simplex 10.0
37 goodpasture syndrome 10.0 NID1 VCAM1
38 retinal detachment 10.0
39 crohn's disease 10.0
40 diabetes mellitus 10.0
41 corneal disease 10.0
42 corneal edema 10.0
43 axenfeld-rieger syndrome, type 1 9.9 BMP4 PAX6
44 strabismus 9.9
45 insulin-like growth factor i 9.9
46 astigmatism 9.9
47 kawasaki disease 9.9
48 sleep apnea 9.9
49 lymphoma 9.9
50 cogan syndrome 9.9

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to Keratopathy

Symptoms & Phenotypes for Keratopathy

MGI Mouse Phenotypes related to Keratopathy:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.16 AIRE AKR1B1 BMP4 FBN1 IGF1 NLRP1
2 behavior/neurological MP:0005386 10.11 AIRE AKR1B1 BMP4 FBN1 NID1 PAX6
3 cardiovascular system MP:0005385 10.1 BMP4 FBN1 IGF1 NID1 PAX6 TAC1
4 nervous system MP:0003631 10.01 AIRE BMP4 FBN1 IGF1 NID1 PAX6
5 muscle MP:0005369 9.91 BMP4 FBN1 IGF1 NID1 PAX6 TGFB2
6 hearing/vestibular/ear MP:0005377 9.88 BMP4 IGF1 PAX6 TGFB2 TNC
7 normal MP:0002873 9.87 AIRE BMP4 IGF1 KRT12 PAX6 TAC1
8 no phenotypic analysis MP:0003012 9.85 AIRE BMP4 FBN1 KRT12 TNC VCAM1
9 renal/urinary system MP:0005367 9.8 AKR1B1 BMP4 FBN1 IGF1 PAX6 TAC1
10 reproductive system MP:0005389 9.7 AIRE BMP4 FBN1 IGF1 PAX6 TGFB2
11 respiratory system MP:0005388 9.43 AIRE BMP4 FBN1 IGF1 PAX6 TGFB2
12 vision/eye MP:0005391 9.17 AIRE AKR1B1 BMP4 KRT12 NID1 PAX6

Drugs & Therapeutics for Keratopathy

Drugs for Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 105)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
2
Acetylcholine Approved, Investigational Phase 2, Phase 3 51-84-3 187
3
Primaquine Approved Phase 3,Phase 2 90-34-6 4908
4
chloroquine Approved, Investigational, Vet_approved Phase 3,Phase 2 54-05-7 2719
5 Orange Approved Phase 3
6
Tafenoquine Approved, Investigational Phase 3,Phase 2,Phase 1 106635-80-7
7 Botulinum Toxins, Type A Phase 2, Phase 3
8 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3,Not Applicable
9 abobotulinumtoxinA Phase 2, Phase 3
10 Botulinum Toxins Phase 2, Phase 3
11 Neuromuscular Agents Phase 2, Phase 3
12 Acetylcholine Release Inhibitors Phase 2, Phase 3
13 Cholinergic Agents Phase 2, Phase 3
14 Neurotransmitter Agents Phase 2, Phase 3
15 Ophthalmic Solutions Phase 3,Phase 1,Phase 2,Not Applicable
16 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2
17 Antimalarials Phase 3,Phase 2,Phase 1
18 Anthelmintics Phase 3,Phase 2
19 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
20 Chloroquine diphosphate Phase 3,Phase 2 50-63-5
21 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
22 Analgesics Phase 3,Phase 2
23 Antiparasitic Agents Phase 3,Phase 2,Phase 1
24 Analgesics, Non-Narcotic Phase 3,Phase 2
25 Antiprotozoal Agents Phase 3,Phase 2,Phase 1
26 Antirheumatic Agents Phase 3,Phase 2,Not Applicable
27
Bevacizumab Approved, Investigational Phase 2,Not Applicable 216974-75-3
28
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
29
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
30
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
31
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
32
Fluorometholone Approved, Investigational Phase 2,Not Applicable 426-13-1 9878
33
Miconazole Approved, Investigational, Vet_approved Phase 2,Not Applicable 22916-47-8 4189
34
Loteprednol Approved, Experimental Phase 2 82034-46-6, 129260-79-3 9865442 444025
35
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
36
Ambroxol Investigational Phase 1, Phase 2 18683-91-5
37 Mitogens Phase 2
38 Antibodies Phase 2
39 Endothelial Growth Factors Phase 2
40 Antibodies, Monoclonal Phase 2
41 Antineoplastic Agents, Immunological Phase 2,Not Applicable
42 Angiogenesis Inhibitors Phase 2,Not Applicable
43 Immunoglobulins Phase 2
44 Angiogenesis Modulating Agents Phase 2,Not Applicable
45 Protective Agents Phase 2,Not Applicable
46 Anesthetics Phase 2,Not Applicable
47 Hormones Phase 2,Not Applicable
48 Autonomic Agents Phase 2,Not Applicable
49 Anti-Allergic Agents Phase 2
50 Prednisolone acetate Phase 2

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 Study of the Presence and Extent of Corneal Disturbance Associated With B+L Biotrue MPS Used With B+L PureVision Lenses Completed NCT01268306 Phase 4
2 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
3 Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria Completed NCT02216123 Phase 3 Tafenoquine;Tafenoquine Placebo;Chloroquine;Primaquine;Primaquine Placebo
4 Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1 Recruiting NCT02600429 Phase 3 RGN-259;Placebo
5 Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation Active, not recruiting NCT03248037 Phase 3 Netarsudil;Placebo
6 Stem Cells Treatment for Bilateral Limbic Associated Keratopathy (HULPOFT) Unknown status NCT01808378 Phase 2 Expanded adipose-derived stem cells
7 Bevacizumab for the Treatment of Corneal Neovascularization Unknown status NCT00992849 Phase 2 Bevacizumab
8 Amniotic Membrane Graft In Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
9 Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK) Completed NCT01448213 Phase 2 Prednisolone acetate;Fluorometholone
10 Study Evaluating Efficacy and Safety of SAR566658 Treatment in Patients With CA6 Positive Metastatic Triple Negative Breast Cancer Completed NCT02984683 Phase 2 SAR566658 (ACT14884)
11 Utilization of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal Healing Completed NCT02746848 Phase 1, Phase 2
12 Pain and Visual Outcome in Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
13 Effects of Oral Mucolytics on Tear Film and Ocular Surface Completed NCT01713179 Phase 1, Phase 2 Ambroxol hydrochloride (Mucopect®, 60 mg, Boehringer Ingelheim)
14 Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapse Completed NCT01376167 Phase 2 Chloroquine 600mg;Chloroquine 300mg;Tafenoquine 50mg;Tafenoquine 100mg;Tafenoquine 300mg;Tafenoquine 600mg;Primaquine 15mg;Chloroquine 600mg (Part 2 );Chloroquine 300mg (Part 2 );Tafenoquine 300mg (Part 2);Primaquine 15mg (Part2 )
15 An Extension to Study MD7108240 Completed NCT00733304 Phase 2 Pazopanib
16 Lotemax® Gel 0.5% and Restasis 0.05% in Subjects With Mild or Moderate Keratoconjunctivitis Sicca Completed NCT01817582 Phase 2 Lotemax Gel + Restasis;Lotemax Gel;Restasis
17 A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Recruiting NCT03084861 Phase 1, Phase 2 Cord Blood Eye Drops;Conventional treatment
18 Study of Ataluren in Participants With Nonsense Mutation Aniridia Active, not recruiting NCT02647359 Phase 2 Ataluren;Placebo
19 A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) Patients Terminated NCT01972438 Phase 2 ASEDs;Saline
20 A Study of SAR428926 in Patients With Advanced Solid Tumors Completed NCT02575781 Phase 1 SAR428926
21 Assessment of Any Potential Retinal Effects of Tafenoquine (TQ) Completed NCT02658435 Phase 1 Tafenoquine 150 mg;Matched placebo 150mg
22 Blood Based Eyedrops From Different Sources in the Treatment of Severe Keratopathy Unknown status NCT03064984 Not Applicable
23 Corneal Transplantation Guided by OCT RESCAN Unknown status NCT02736877 Not Applicable
24 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584 Not Applicable
25 Comparing Endoglide to Endoserter for DSAEK Graft Insertion Unknown status NCT01791075 Not Applicable
26 Staged and Combined Surgery for Cataract Patients With Corneal Endothelial Dysfunction Unknown status NCT02523950 Not Applicable
27 Comparison of Aqueous and Plasma Glucose Level in Diabetic Patients Unknown status NCT02750098 Not Applicable
28 Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 Not Applicable saline solution
29 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044 Not Applicable
30 Is Sjögren's Syndrome Associated With Meibomian Gland Dysfunction ? Unknown status NCT03060005 Not Applicable Tears Naturale Forte;liposic
31 Long Term Results of Amniotic Membrane Transplant in Bullous Keratopathy Patients Completed NCT03450954
32 Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308 Not Applicable
33 The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous Keratopathy Completed NCT01106274 Not Applicable
34 Automated Lamellar Keratectomy in Symptomatic Patients With Bullous Keratopathy Completed NCT00654888 Not Applicable Mitomycin
35 Eyelash Line Resection for Entropion Associated With Down's Syndrome Completed NCT01758718 Not Applicable
36 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
37 A Comparison of Hydrogel Dressings and Ocular Lubricants in the Prevention on Corneal Damage in the Critically Ill Completed NCT00513734 Not Applicable
38 Safety and Effectiveness of Subconjunctival Injection of Bevacizumab in the Treatment of Corneal Neovasculization Completed NCT00681603 Not Applicable subconjunctival injection of bevacizumab ( 1.25 to 2.50 mg)
39 Comparison of Patient Comfort After Two Anesthetic Protocols for Injections Into the Eye Completed NCT01087489 Not Applicable 4% lidocaine;3.5% ophthalmic lidocaine gel
40 Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Completed NCT02660151 Not Applicable Salt solution
41 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467 Not Applicable Cyclosporin 0.05% ophthalmic
42 Study of Endothelial Keratoplasty Outcomes Completed NCT00800111 Not Applicable
43 Evaluation of Dry Eye and Meibomian Gland Dysfunction After Cataract Surgery Completed NCT01942642
44 Adequate Sock to Avoid Hiking Injuries Completed NCT03914274 Not Applicable
45 Corneal WFG Versus AF Trans PRK in Myopic Patients With High Corneal HOA Completed NCT03786861 Not Applicable
46 Correlation of Gene Abnormalities and Clinical Manifestations of Aniridia Completed NCT00265590
47 Visual Quality and Contrast Sensitivity Function After Corneal Transplantation Recruiting NCT03447041
48 Air Versus SF6 for Descemet's Membrane Endothelial Keratoplasty (DMEK) Recruiting NCT03407755 Not Applicable
49 The ADVISE Study: Advanced Visualization In Corneal Surgery Evaluation Recruiting NCT03763721 Not Applicable
50 Evaluating Medium-chain Triglycerides as a Temporary Intraocular Tamponading Agent for Retinal Detachment Recruiting NCT03855462 Not Applicable

Search NIH Clinical Center for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

Anatomical Context for Keratopathy

MalaCards organs/tissues related to Keratopathy:

42
Endothelial, Eye, Lung, B Cells, Breast, Thyroid, Brain

Publications for Keratopathy

Articles related to Keratopathy:

(show top 50) (show all 1084)
# Title Authors Year
1
Topical insulin in neurotrophic keratopathy after resection of acoustic neuroma. ( 30025986 )
2019
2
Treatment of corneal neovascularization with topical aflibercept in a case of exposure keratopathy following cerebellar astrocytoma surgery. ( 30574927 )
2019
3
Dry eye and meibomian gland dysfunction in pseudophakic bullous keratopathy. ( 29392636 )
2019
4
Cytokine Levels in the Aqueous Humor Are Associated With Corneal Thickness in Eyes With Bullous Keratopathy. ( 30316668 )
2019
5
Effect of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy. ( 30783940 )
2019
6
Triple procedure for pseudophakic bullous keratopathy in complicated cataract surgery: Glued IOL with single-pass four-throw pupilloplasty with pre-Descemet's endothelial keratoplasty. ( 30819560 )
2019
7
Different graft thicknesses after Descemet stripping endothelial keratoplasty for bullous keratopathy in the two eyes of the same patient. ( 30881147 )
2019
8
Decreased epithelial to corneal thickness ratio in healthy fellow eyes of patients with unilateral bullous keratopathy. ( 31000511 )
2019
9
Paraproteinemic keratopathy associated with monoclonal gammopathy of undetermined significance (MGUS): clinical findings in twelve patients including recurrence after keratoplasty. ( 31044553 )
2019
10
Meibomian gland dysfunction and keratopathy are associated with dry eye disease in aniridia. ( 29519880 )
2019
11
A Study of Corneal Biomechanics in Delayed-Onset Mustard Gas Keratopathy Compared to Cases With Corneal Scarring and Normal Corneas. ( 30005052 )
2019
12
In vivo microscopic and optical coherence tomography classification of neurotrophic keratopathy. ( 30240004 )
2019
13
In vivo confocal microscopy of multiple myeloma associated crystalline keratopathy. ( 30561166 )
2019
14
Crystalline Keratopathy in Post-LASIK Ectasia: A Case Report. ( 30575622 )
2019
15
Characterization of corneal deposition keratopathy in the setting of blood cell dyscrasia and a minimally invasive technique to clear the cornea in a single case. ( 30619968 )
2019
16
Fluocinolone acetonide intravitreal implant as a therapeutic option for severe Sjögren's syndrome-related keratopathy: a case report. ( 30674351 )
2019
17
Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy. ( 30679185 )
2019
18
Polyquaternium-1-Associated Dendritiform Keratopathy. ( 30702469 )
2019
19
Central Toxic Keratopathy After Contact Lens Wear and Mechanical Debridement: Clinical Characteristics, and Visual and Corneal Tomographic Outcomes. ( 30707128 )
2019
20
Medial canthoplasty for the management of exposure keratopathy. ( 30710111 )
2019
21
Post-herpes neurotrophic keratopathy: Aetiopathogenesis, clinical signs and current therapies. ( 30718014 )
2019
22
Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation. ( 30770356 )
2019
23
Evaluation of corneal biomechanical properties in mustard gas keratopathy. ( 30930659 )
2019
24
Severe toxic keratopathy after topical natamycin and ceftazidime use in an infant. ( 30947499 )
2019
25
The Development of Keratopathy after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study. ( 30959733 )
2019
26
Multimodal Imaging Report of Crystalline Keratopathy in Relapsing Polychondritis. ( 30969261 )
2019
27
Superficial punctate keratopathy in a pediatric patient was related to adenoid hypertrophy and obstructive sleep apnea syndrome: a case report. ( 29471795 )
2018
28
Nitisinone-Induced Keratopathy in Alkaptonuria: A Challenging Diagnosis Despite Clinical Suspicion. ( 28879639 )
2018
29
Asymptomatic Corneal Keratopathy Secondary to Hypertyrosinaemia Following Low Dose Nitisinone and a Literature Review of Tyrosine Keratopathy in Alkaptonuria. ( 28942493 )
2018
30
Topical ganciclovir treatment post-Descemet's stripping automated endothelial keratoplasty for patients with bullous keratopathy induced by cytomegalovirus. ( 29363530 )
2018
31
Human corneal endothelial cell transplantation using nanocomposite gel sheet in bullous keratopathy. ( 29531856 )
2018
32
Primary Bullous Keratopathy in a Patient With Werner Syndrome Treated With Corneal Transplant. ( 29534662 )
2018
33
Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy. ( 29539291 )
2018
34
Painless bilateral bullous keratopathy. ( 29573998 )
2018
35
Bilateral bullous keratopathy secondary to melting keratitis in a Suri alpaca (Vicugna pacos). ( 29636928 )
2018
36
Wheel Spokes Technique for Endothelial Keratoplasty for Extremely Mydriatic Bullous Keratopathy Eyes without Capsular Support. ( 29681843 )
2018
37
Glued intraocular lens with descemet stripping endothelial keratoplasty in aphakic bullous keratopathy. ( 29692490 )
2018
38
Endothelial cell loss and graft survival after penetrating keratoplasty for laser iridotomy-induced bullous keratopathy. ( 29766356 )
2018
39
Primary Descemet's Membrane Endothelial Keratoplasty for Fuchs Endothelial Dystrophy versus Bullous Keratopathy: Histopathology and Clinical Results. ( 29939775 )
2018
40
Sustainability of Pain Relief After Corneal Collagen Cross-Linking in Eyes With Bullous Keratopathy. ( 29993202 )
2018
41
Cultured Cells and ROCK Inhibitor for Bullous Keratopathy. ( 30231219 )
2018
42
Cultured Cells and ROCK Inhibitor for Bullous Keratopathy. ( 30260152 )
2018
43
Cultured Cells and ROCK Inhibitor for Bullous Keratopathy. ( 30260153 )
2018
44
Management of Candida glabrata infectious crystalline keratopathy with endophthalmitis following penetrating keratoplasty. ( 29941758 )
2018
45
Atypical Presentation of Iridocorneal Endothelial Syndrome With Band Keratopathy but No Corneal Edema Managed With Descemet Membrane Endothelial Keratoplasty. ( 29668572 )
2018
46
In Vivo Confocal Microscopic Study of Hard Contact Lens-Induced Lipid Keratopathy Secondary to Corneal Neovascularization in a Rabbit Hypercholesterolemic Model. ( 29489496 )
2018
47
A Case of Diprosopus Tetraophthalmos: Ocular Findings and Surgical Treatment of Exposure Keratopathy. ( 30320715 )
2018
48
In Vivo Confocal Microscopic Observations of Vortex Keratopathy in Patients with Amiodarone-Induced Keratopathy and Fabry Disease. ( 29750121 )
2018
49
Nurses can play an active role in the early diagnosis of exposure keratopathy in intensive care patients. ( 28169512 )
2018
50
In Vivo Confocal Microscopic Characteristics of Crystalline Keratopathy in Patients with Sclerokeratitis. ( 28282739 )
2018

Variations for Keratopathy

Expression for Keratopathy

Search GEO for disease gene expression data for Keratopathy.

Pathways for Keratopathy

GO Terms for Keratopathy

Cellular components related to Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 BMP4 FBN1 IGF1 NID1 TAC1 TGFB2
2 basement membrane GO:0005604 9.33 FBN1 NID1 TNC
3 collagen-containing extracellular matrix GO:0062023 9.26 FBN1 NID1 TGFB2 TNC
4 extracellular space GO:0005615 9.23 AKR1B1 BMP4 FBN1 IGF1 TAC1 TGFB2

Biological processes related to Keratopathy according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.92 BMP4 IGF1 TGFB2 TNC
2 regulation of signaling receptor activity GO:0010469 9.87 BMP4 FBN1 IGF1 TGFB2
3 positive regulation of gene expression GO:0010628 9.86 BMP4 IGF1 PAX6 TNC
4 regulation of gene expression GO:0010468 9.82 BMP4 IGF1 PAX6
5 kidney development GO:0001822 9.72 BMP4 FBN1 TGFB2
6 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.64 BMP4 IGF1
7 positive regulation of epithelial cell migration GO:0010634 9.63 TAC1 TGFB2
8 eye development GO:0001654 9.63 PAX6 TGFB2
9 response to wounding GO:0009611 9.63 PAX6 TGFB2 TNC
10 metanephros development GO:0001656 9.62 BMP4 FBN1
11 cellular protein metabolic process GO:0044267 9.62 BMP4 FBN1 IGF1 TNC
12 odontogenesis GO:0042476 9.61 BMP4 TGFB2
13 neuron fate commitment GO:0048663 9.61 BMP4 PAX6
14 pituitary gland development GO:0021983 9.6 BMP4 PAX6
15 outflow tract septum morphogenesis GO:0003148 9.59 BMP4 TGFB2
16 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.58 BMP4 TGFB2
17 camera-type eye development GO:0043010 9.58 BMP4 FBN1 PAX6
18 cardiac right ventricle morphogenesis GO:0003215 9.54 BMP4 TGFB2
19 negative regulation of epithelial cell proliferation GO:0050680 9.54 BMP4 PAX6 TGFB2
20 pulmonary valve morphogenesis GO:0003184 9.52 BMP4 TGFB2
21 membranous septum morphogenesis GO:0003149 9.51 BMP4 TGFB2
22 salivary gland morphogenesis GO:0007435 9.49 PAX6 TGFB2
23 pharyngeal arch artery morphogenesis GO:0061626 9.48 BMP4 TGFB2
24 extracellular matrix organization GO:0030198 9.46 FBN1 NID1 TNC VCAM1
25 telencephalon regionalization GO:0021978 9.43 BMP4 PAX6
26 positive regulation of smooth muscle cell proliferation GO:0048661 9.43 AKR1B1 BMP4 IGF1
27 renal system development GO:0072001 9.27 BMP4
28 skeletal system development GO:0001501 9.26 BMP4 FBN1 IGF1 TGFB2
29 positive regulation of ossification GO:0045778 8.8 BMP4 TAC1 TGFB2

Molecular functions related to Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 BMP4 IGF1 TGFB2
2 integrin binding GO:0005178 9.13 FBN1 IGF1 VCAM1
3 extracellular matrix structural constituent GO:0005201 8.8 FBN1 NID1 TNC

Sources for Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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