Aliases & Classifications for Keratopathy

MalaCards integrated aliases for Keratopathy:

Name: Keratopathy 38 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2283
NCIt 50 C27012
UMLS 73 C0235270

Summaries for Keratopathy

MalaCards based summary : Keratopathy is related to bullous keratopathy and limbal stem cell deficiency. An important gene associated with Keratopathy is PAX6 (Paired Box 6), and among its related pathways/superpathways are Degradation of the extracellular matrix and ECM-receptor interaction. The drugs Pharmaceutical Solutions and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and thyroid, and related phenotypes are no phenotypic analysis and normal

Related Diseases for Keratopathy

Diseases related to Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 bullous keratopathy 33.1 FBN1 NID1 TNC
2 limbal stem cell deficiency 29.7 KRT12 VCAM1
3 microvascular complications of diabetes 5 28.6 AKR1B1 IGF1 VCAM1
4 neurotrophic keratopathy 12.0
5 corneal dystrophy, band-shaped 11.6
6 schnyder corneal dystrophy 10.9
7 palmoplantar carcinoma, multiple self-healing 10.9
8 corneal degeneration, ribbonlike, with deafness 10.9
9 endotheliitis 10.4
10 autoimmune addison disease 10.4 AIRE NLRP1
11 exotropia 10.2 FBN1 TUBB3
12 pseudopapilledema 10.2 IGF1 PAX6
13 pathologic nystagmus 10.2 PAX6 TUBB3
14 peripheral artery disease 10.1 NLRP1 VCAM1
15 cataract 10.1
16 congenital ptosis 10.1 PAX6 TUBB3
17 congenital nystagmus 10.0 PAX6 TUBB3
18 lagophthalmos 10.0
19 poland syndrome 10.0 PAX6 TUBB3
20 myeloma, multiple 10.0
21 keratoconus 10.0
22 corneal dystrophy, fuchs endothelial, 1 9.9
23 fuchs' endothelial dystrophy 9.9
24 monoclonal gammopathy of uncertain significance 9.9
25 aniridia 1 9.8
26 alkaptonuria 9.8
27 fabry disease 9.8
28 corneal neovascularization 9.8
29 herpes zoster 9.8
30 arthritis 9.8
31 diabetes mellitus 9.8
32 corneal disease 9.8
33 corneal edema 9.8
34 herpes simplex 9.8
35 apnea, obstructive sleep 9.7
36 rheumatoid arthritis 9.7
37 strabismus 9.7
38 insulin-like growth factor i 9.7
39 astigmatism 9.7
40 kawasaki disease 9.7
41 crohn's disease 9.7
42 sleep apnea 9.7
43 lymphoma 9.7
44 ptosis 9.7
45 xerophthalmia 9.7
46 cystinosis 9.7
47 keratomalacia 9.7
48 choroiditis 9.7
49 corneal deposit 9.7
50 myopia 9.7

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to Keratopathy

Symptoms & Phenotypes for Keratopathy

MGI Mouse Phenotypes related to Keratopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.65 AIRE FBN1 KRT12 TNC VCAM1
2 normal MP:0002873 9.63 AIRE IGF1 KRT12 PAX6 TAC1 TNC
3 renal/urinary system MP:0005367 9.35 AKR1B1 FBN1 IGF1 PAX6 TAC1
4 respiratory system MP:0005388 9.02 AIRE FBN1 IGF1 PAX6 TUBB3

Drugs & Therapeutics for Keratopathy

Drugs for Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
2
Acetylcholine Approved Phase 2, Phase 3 51-84-3 187
3
chloroquine Approved, Investigational, Vet_approved Phase 3,Phase 2 54-05-7 2719
4
Primaquine Approved Phase 3,Phase 2 90-34-6 4908
5 Orange Approved, Nutraceutical Phase 3
6 Tafenoquine Investigational Phase 3,Phase 2,Phase 1 106635-80-7
7 abobotulinumtoxinA Phase 2, Phase 3
8 Botulinum Toxins Phase 2, Phase 3
9 Botulinum Toxins, Type A Phase 2, Phase 3
10 Cholinergic Agents Phase 2, Phase 3
11 Neuromuscular Agents Phase 2, Phase 3
12 Neurotransmitter Agents Phase 2, Phase 3
13 onabotulinumtoxinA Phase 2, Phase 3
14 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
15 Analgesics Phase 3,Phase 2
16 Analgesics, Non-Narcotic Phase 3,Phase 2
17 Anthelmintics Phase 3,Phase 2
18 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
19 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
20 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2
21 Antimalarials Phase 3,Phase 2,Phase 1
22 Antiparasitic Agents Phase 3,Phase 2,Phase 1
23 Antiprotozoal Agents Phase 3,Phase 2,Phase 1
24 Antirheumatic Agents Phase 3,Phase 2,Not Applicable
25 Chloroquine diphosphate Phase 3,Phase 2 50-63-5
26 Ophthalmic Solutions Phase 3,Phase 1,Phase 2,Not Applicable
27 Tetrahydrozoline Phase 3,Phase 1,Phase 2,Not Applicable
28
Bevacizumab Approved, Investigational Phase 2,Not Applicable 216974-75-3
29
Fluorometholone Approved, Investigational Phase 2,Not Applicable 426-13-1 9878
30
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
31
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
32
Ephedrine Approved Phase 1, Phase 2,Phase 2,Not Applicable 299-42-3 9294
33
Pseudoephedrine Approved Phase 1, Phase 2,Phase 2,Not Applicable 90-82-4 7028
34
Ambroxol Approved, Investigational Phase 1, Phase 2 18683-91-5
35
Loteprednol Approved Phase 2 82034-46-6, 129260-79-3 444025 9865442
36
Miconazole Approved, Investigational, Vet_approved Phase 2,Not Applicable 22916-47-8 4189
37 Angiogenesis Inhibitors Phase 2,Not Applicable
38 Angiogenesis Modulating Agents Phase 2,Not Applicable
39 Antibodies Phase 2
40 Antibodies, Monoclonal Phase 2
41 Endothelial Growth Factors Phase 2
42 Immunoglobulins Phase 2
43 Mitogens Phase 2
44 Anesthetics Phase 2,Not Applicable
45 Anti-Allergic Agents Phase 2
46 Antiemetics Phase 2,Not Applicable
47 Antineoplastic Agents, Hormonal Phase 2,Not Applicable
48 Autonomic Agents Phase 2,Phase 1,Not Applicable
49 Gastrointestinal Agents Phase 2,Not Applicable
50 glucocorticoids Phase 2,Not Applicable

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Study of the Presence and Extent of Corneal Disturbance Associated With B+L Biotrue MPS Used With B+L PureVision Lenses Completed NCT01268306 Phase 4
2 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
3 Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria Completed NCT02216123 Phase 3 Tafenoquine;Tafenoquine Placebo;Chloroquine;Primaquine;Primaquine Placebo
4 Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1 Recruiting NCT02600429 Phase 3 RGN-259;Placebo
5 Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation Recruiting NCT03248037 Phase 3 Netarsudil;Placebo
6 Stem Cells Treatment for Bilateral Limbic Associated Keratopathy (HULPOFT) Unknown status NCT01808378 Phase 2 Expanded adipose-derived stem cells
7 Bevacizumab for the Treatment of Corneal Neovascularization Unknown status NCT00992849 Phase 2 Bevacizumab
8 Amniotic Membrane Graft In Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
9 Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK) Completed NCT01448213 Phase 2 Prednisolone acetate;Fluorometholone
10 Utilization of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal Healing Completed NCT02746848 Phase 1, Phase 2
11 Pain and Visual Outcome in Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
12 Effects of Oral Mucolytics on Tear Film and Ocular Surface Completed NCT01713179 Phase 1, Phase 2 Ambroxol hydrochloride (Mucopect®, 60 mg, Boehringer Ingelheim)
13 Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapse Completed NCT01376167 Phase 2 Chloroquine 600mg;Chloroquine 300mg;Tafenoquine 50mg;Tafenoquine 100mg;Tafenoquine 300mg;Tafenoquine 600mg;Primaquine 15mg;Chloroquine 600mg (Part 2 );Chloroquine 300mg (Part 2 );Tafenoquine 300mg (Part 2);Primaquine 15mg (Part2 )
14 An Extension to Study MD7108240 Completed NCT00733304 Phase 2 Pazopanib
15 Lotemax® Gel 0.5% and Restasis 0.05% in Subjects With Mild or Moderate Keratoconjunctivitis Sicca Completed NCT01817582 Phase 2 Lotemax Gel + Restasis;Lotemax Gel;Restasis
16 A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Recruiting NCT03084861 Phase 1, Phase 2 Cord Blood Eye Drops;Conventional treatment
17 Study Evaluating Efficacy and Safety of SAR566658 Treatment in Patients With CA6 Positive Metastatic Triple Negative Breast Cancer Recruiting NCT02984683 Phase 2 SAR566658 (ACT14884)
18 Study of Ataluren in Patients With Aniridia Active, not recruiting NCT02647359 Phase 2 Ataluren;Placebo
19 A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) Patients Terminated NCT01972438 Phase 2 ASEDs;Saline
20 Assessment of Any Potential Retinal Effects of Tafenoquine (TQ) Completed NCT02658435 Phase 1 Tafenoquine 150 mg;Matched placebo 150mg
21 A Study of SAR428926 in Patients With Advanced Solid Tumors Active, not recruiting NCT02575781 Phase 1 SAR428926
22 Corneal Transplantation Guided by OCT RESCAN Unknown status NCT02736877 Not Applicable
23 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584 Not Applicable
24 Comparing Endoglide to Endoserter for DSAEK Graft Insertion Unknown status NCT01791075 Not Applicable
25 Staged and Combined Surgery for Cataract Patients With Corneal Endothelial Dysfunction Unknown status NCT02523950 Not Applicable
26 Comparison of Aqueous and Plasma Glucose Level in Diabetic Patients Unknown status NCT02750098 Not Applicable
27 Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 Not Applicable saline solution
28 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044 Not Applicable
29 Long Term Results of Amniotic Membrane Transplant in Bullous Keratopathy Patients Completed NCT03450954
30 Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308 Not Applicable
31 The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous Keratopathy Completed NCT01106274 Not Applicable
32 Automated Lamellar Keratectomy in Symptomatic Patients With Bullous Keratopathy Completed NCT00654888 Not Applicable Mitomycin
33 Eyelash Line Resection for Entropion Associated With Down's Syndrome Completed NCT01758718 Not Applicable
34 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
35 A Comparison of Hydrogel Dressings and Ocular Lubricants in the Prevention on Corneal Damage in the Critically Ill Completed NCT00513734 Not Applicable
36 Safety and Effectiveness of Subconjunctival Injection of Bevacizumab in the Treatment of Corneal Neovasculization Completed NCT00681603 Not Applicable subconjunctival injection of bevacizumab ( 1.25 to 2.50 mg)
37 Comparison of Patient Comfort After Two Anesthetic Protocols for Injections Into the Eye Completed NCT01087489 Not Applicable 4% lidocaine;3.5% ophthalmic lidocaine gel
38 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467 Not Applicable Cyclosporin 0.05% ophthalmic
39 Evaluation of Dry Eye and Meibomian Gland Dysfunction After Cataract Surgery Completed NCT01942642
40 Correlation of Gene Abnormalities and Clinical Manifestations of Aniridia Completed NCT00265590
41 Blood Based Eyedrops From Different Sources in the Treatment of Severe Keratopathy Recruiting NCT03064984 Not Applicable
42 Visual Quality and Contrast Sensitivity Function After Corneal Transplantation Recruiting NCT03447041
43 Air Versus SF6 for Descemet's Membrane Endothelial Keratoplasty (DMEK) Recruiting NCT03407755 Not Applicable
44 Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Recruiting NCT02660151 Not Applicable Salt solution
45 Study of Endothelial Keratoplasty Outcomes Recruiting NCT00800111 Not Applicable
46 Endoscopy Assisted Probing Versus Simple Probing in Primary Congenital Nasolacrimal Duct Obstruction Recruiting NCT03242681 Not Applicable
47 Sjögren's Syndrome Is Associated With Meibomian Gland Dysfunction Recruiting NCT03434106 Not Applicable liposic;Tears Naturale Forte
48 Is Sjögren's Syndrome Associated With Meibomian Gland Dysfunction ? Recruiting NCT03060005 Not Applicable Tears Naturale Forte;liposic
49 Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation Withdrawn NCT01682421 Not Applicable Weak steroid (Flurolon, Allergan);Potent steroid (Maxidex, Alcon)

Search NIH Clinical Center for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

Anatomical Context for Keratopathy

MalaCards organs/tissues related to Keratopathy:

41
Endothelial, Eye, Thyroid, Brain, B Cells, T Cells, Skin

Publications for Keratopathy

Articles related to Keratopathy:

(show top 50) (show all 800)
# Title Authors Year
1
A Case of Neurotrophic Keratopathy Associated with Nasopharyngeal Carcinoma. ( 29643792 )
2018
2
Pigmentary keratopathy in a child: Histopathologic analysis. ( 29370944 )
2018
3
A hybrid technique to address exposure keratopathy secondary to facial nerve paresis: A combination of a lateral tarsorrhaphy and lateral wedge resection. ( 29776684 )
2018
4
Primary Bullous Keratopathy in a Patient With Werner Syndrome Treated With Corneal Transplant. ( 29534662 )
2018
5
Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy. ( 29539291 )
2018
6
Primary Descemet's Membrane Endothelial Keratoplasty for Fuchs Endothelial Dystrophy versus Bullous Keratopathy: Histopathology and Clinical Results. ( 29939775 )
2018
7
Clinical and Histological Characterization of Toxic Keratopathy From Depatuxizumab Mafodotin (ABT-414), an Antibody-Drug Conjugate. ( 29794826 )
2018
8
Modeling of Aniridia-Related Keratopathy by CRISPR/Cas9 Genome Editing of Human Limbal Epithelial Cells and Rescue by Recombinant PAX6 Protein. ( 29808941 )
2018
9
Pediatric primary calcific band keratopathy with or without glaucoma from biallelic SLC4A4 mutations. ( 29671668 )
2018
10
Human corneal endothelial cell transplantation using nanocomposite gel sheet in bullous keratopathy. ( 29531856 )
2018
11
Cerebellar Ataxia With Neuropathy and Vestibular Areflexia Syndrome Presenting With Neurotrophic Keratopathy. ( 29474200 )
2018
12
Corneal Neurotization for Neurotrophic Keratopathy: Clinical Outcomes and In Vivo Confocal Microscopic and Histopathological Findings. ( 29373338 )
2018
13
Incidence, risk factors and impact of protocolised care on exposure keratopathy in critically ill adults: a two-phase prospective cohort study. ( 29338772 )
2018
14
Painless bilateral bullous keratopathy. ( 29573998 )
2018
15
Use of an Ocular Wound Chamber for the Prevention of Exposure Keratopathy in a Guinea Pig Model. ( 29943888 )
2018
16
Inhibition of Soluble Epoxide Hydrolase 2 Ameliorates Diabetic Keratopathy and Impaired Wound Healing in Mouse Corneas. ( 29615440 )
2018
17
Management of <i>Candida glabrata</i> infectious crystalline keratopathy with endophthalmitis following penetrating keratoplasty. ( 29941758 )
2018
18
Topical ganciclovir treatment post-Descemet's stripping automated endothelial keratoplasty for patients with bullous keratopathy induced by cytomegalovirus. ( 29363530 )
2018
19
Dry eye and meibomian gland dysfunction in pseudophakic bullous keratopathy. ( 29392636 )
2018
20
Stage-related central corneal epithelial transformation in congenital aniridia-associated keratopathy. ( 29133179 )
2018
21
Wheel Spokes Technique for Endothelial Keratoplasty for Extremely Mydriatic Bullous Keratopathy Eyes without Capsular Support. ( 29681843 )
2018
22
Neurotrophic Keratopathy after Trigeminal Nerve Block for Treatment of Postherpetic Neuralgia. ( 29955409 )
2018
23
A Case of Neurotrophic Keratopathy Concomitant to Brain Metastasis. ( 29755905 )
2018
24
In Vivo Confocal Microscopy Reveals Corneal Reinnervation After Treatment of Neurotrophic Keratopathy With Corneal Neurotization. ( 29053558 )
2018
25
<i>In Vivo</i> Confocal Microscopic Observations of Vortex Keratopathy in Patients with Amiodarone-Induced Keratopathy and Fabry Disease. ( 29750121 )
2018
26
Vitamin B12 Deficiency as a Cause of Neurotrophic Keratopathy. ( 29541277 )
2018
27
In Vivo Confocal Microscopic Study of Hard Contact Lens-Induced Lipid Keratopathy Secondary to Corneal Neovascularization in a Rabbit Hypercholesterolemic Model. ( 29489496 )
2018
28
Endothelial cell loss and graft survival after penetrating keratoplasty for laser iridotomy-induced bullous keratopathy. ( 29766356 )
2018
29
Atypical Presentation of Iridocorneal Endothelial Syndrome With Band Keratopathy but No Corneal Edema Managed With Descemet Membrane Endothelial Keratoplasty. ( 29668572 )
2018
30
Corneal Abnormalities in Congenital Aniridia: Congenital Central Corneal Opacity Versus Aniridia-associated Keratopathy. ( 29101006 )
2018
31
EDTA chelation for symptomatic band keratopathy: results and recurrence. ( 29192681 )
2018
32
Bilateral bullous keratopathy secondary to melting keratitis in a Suri alpaca (<i>Vicugna pacos</i>). ( 29636928 )
2018
33
Neurotrophic keratopathy. ( 29698813 )
2018
34
Superficial punctate keratopathy in a pediatric patient was related to adenoid hypertrophy and obstructive sleep apnea syndrome: a case report. ( 29471795 )
2018
35
Glued intraocular lens with descemet stripping endothelial keratoplasty in aphakic bullous keratopathy. ( 29692490 )
2018
36
The Impact of Normal Saline on the Incidence of Exposure Keratopathy in Patients Hospitalized in Intensive Care Units. ( 29344048 )
2018
37
Nitisinone-Induced Keratopathy in Alkaptonuria: A Challenging Diagnosis Despite Clinical Suspicion. ( 28879639 )
2017
38
Corneal Neovascularization with Associated Lipid Keratopathy in a Patient with Obstructive Sleep Apnea-Hypopnea Syndrome Using a Continuous Positive Airway Pressure Machine. ( 28924439 )
2017
39
Prevention of Exposure Keratopathy in Critically Ill Patients: A Single-Center, Randomized, Pilot Trial Comparing Ocular Lubrication With Bandage Contact Lenses and Punctal Plugs. ( 28820753 )
2017
40
Factors associated with surface epithelial keratopathy after optical penetrating keratoplasty. ( 28626820 )
2017
41
Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma. ( 28079685 )
2017
42
Young donor-graft assisted endothelial keratoplasty (PDEK/DMEK) with epithelial debridement for chronic pseudophakic bullous keratopathy. ( 28985815 )
2017
43
A rare case of concomitant sicca keratopathy and ipsilateral central facial palsy in Wallenberg's dorsolateral medullary syndrome. ( 28293537 )
2017
44
Asymptomatic Corneal Keratopathy Secondary toA Hypertyrosinaemia Following Low Dose Nitisinone andA aA Literature Review of Tyrosine Keratopathy inA Alkaptonuria. ( 28942493 )
2017
45
Phospholipidomic Studies in Human Cornea From Climatic Droplet Keratopathy. ( 28401586 )
2017
46
Clinical and morphological manifestations of aniridia-associated keratopathy on anterior segment optical coherence tomography and inA vivo confocal microscopy. ( 28698011 )
2017
47
Glad Press'n Seal for the Treatment of Chronic Exposure Keratopathy. ( 28272173 )
2017
48
Innovations in Treatment of Lagophthalmos and Exposure Keratopathy. ( 28885249 )
2017
49
A case report of central toxic keratopathy in a patient post TransPRK (followed by corneal collagen cross-linking). ( 28450791 )
2017
50
Infectious crystalline keratopathy after DescemetAca8-a8cs stripping endothelial keratoplasty. ( 28619977 )
2017

Variations for Keratopathy

Expression for Keratopathy

Search GEO for disease gene expression data for Keratopathy.

Pathways for Keratopathy

GO Terms for Keratopathy

Cellular components related to Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.33 FBN1 NID1 TNC
2 extracellular space GO:0005615 9.17 AKR1B1 FBN1 IGF1 NID1 TAC1 TNC
3 basement membrane GO:0005604 9.13 FBN1 NID1 TNC

Biological processes related to Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.13 FBN1 IGF1 TNC
2 extracellular matrix organization GO:0030198 8.92 FBN1 NID1 TNC VCAM1

Molecular functions related to Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 8.8 FBN1 IGF1 VCAM1

Sources for Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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