Aliases & Classifications for Keratopathy

MalaCards integrated aliases for Keratopathy:

Name: Keratopathy 12 15 37 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2283
NCIt 49 C27012
UMLS 71 C0235270

Summaries for Keratopathy

MalaCards based summary : Keratopathy is related to bullous keratopathy and neurotrophic keratopathy. An important gene associated with Keratopathy is PAX6 (Paired Box 6), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Acetylcholine and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and thyroid, and related phenotypes are cardiovascular system and immune system

Related Diseases for Keratopathy

Diseases related to Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 522)
# Related Disease Score Top Affiliating Genes
1 bullous keratopathy 34.5 NID1 IL1A IGF1 CXCL8
2 neurotrophic keratopathy 34.3 TACR1 TAC1
3 climatic droplet keratopathy 33.7 LACRT JCHAIN
4 keratitis, hereditary 31.4 TNF PAX6 KRT12 CXCL8
5 limbal stem cell deficiency 31.0 KRT12 IL1A ICAM1
6 aniridia 1 30.8 PAX6 KRT12 CYP1B1
7 endophthalmitis 30.6 TNF ICAM1 CXCL8
8 macular retinal edema 30.5 TNF ICAM1 CXCL8 AKR1B1
9 corneal disease 30.4 TNF PAX6 LACRT KRT12 IL1A CXCL8
10 pseudopterygium 30.4 PAX6 KRT12
11 uveitis 30.3 TNF IL4 IL1A ICAM1 CXCL8
12 severe cutaneous adverse reaction 30.3 TNF PAX6 KRT12
13 blepharitis 30.2 TNF LACRT IL4 CXCL8
14 apnea, obstructive sleep 30.2 TNF IGF1 CXCL8
15 posterior uveitis 30.2 TNF IL4 IL1A
16 leprosy 3 30.2 TNF IL4 CXCL8
17 lepromatous leprosy 30.1 TNF IL4 ICAM1
18 haemophilus influenzae 30.1 TNF CXCL8
19 keratoconjunctivitis 30.1 TNF IL4 ICAM1 CXCL8 AIRE
20 exudative vitreoretinopathy 1 30.0 TNF IGF1 CXCL8
21 conjunctivitis 30.0 TNF IL4 ICAM1 CXCL8
22 fibromyalgia 29.9 TNF TACR1 IGF1 CXCL8
23 neurofibromatosis, type ii 29.8 TNF IL1A IGF1 CXCL8
24 candidiasis 29.8 TNF IL4 CXCL8 AIRE
25 leptospirosis 29.8 TNF IL4 CXCL8
26 cataract 29.8 TP53 TNF PAX6 IGF1 ICAM1 CXCL8
27 hypersensitivity reaction type iv disease 29.8 TNF IL4 CXCL8
28 poliomyelitis 29.8 TNF IL4 ICAM1
29 autoimmune disease 29.7 TNF IL4 IL1A CXCL8 AIRE
30 endocarditis 29.7 TNF GAPDH CXCL8
31 herpes simplex virus keratitis 29.7 ICAM1 CXCL8
32 erythema multiforme 29.7 TNF IL4 ICAM1 CXCL8
33 dermatitis 29.7 TNF IL4 IL1A CXCL8
34 neuritis 29.7 TNF IL4 CXCL8
35 sleep apnea 29.6 TNF TAC1 IGF1 ICAM1 CXCL8
36 graves' disease 29.6 IL4 IL1A ICAM1 AIRE
37 macular degeneration, age-related, 1 29.6 TNF PAX6 IGF1 ICAM1 GAPDH CXCL8
38 acquired immunodeficiency syndrome 29.5 TP53 TNF IGF1 ICAM1
39 allergic conjunctivitis 29.5 TNF IL4 ICAM1 CXCL8
40 meningitis 29.4 TNF IL4 ICAM1 CXCL8
41 rhinitis 29.4 TNF IL4 ICAM1 CXCL8
42 allergic hypersensitivity disease 29.4 TNF IL4 ICAM1 CXCL8
43 skin disease 29.3 TNF TAC1 IL4 IL1A ICAM1 CXCL8
44 myeloma, multiple 29.0 TP53 TNF IL4 IGF1 ICAM1 GAPDH
45 peripheral nervous system disease 28.9 TNF TAC1 IL4 IGF1 GAPDH CXCL8
46 basal cell carcinoma 28.7 TP53 TNF ITGB1 ICAM1 CXCL8
47 psoriasis 28.7 TNF ITGB1 IL4 IL1A ICAM1 CXCL8
48 dermatitis, atopic 28.3 TNF TACR1 TAC1 IL4 IL1A ICAM1
49 diabetes mellitus 28.2 TNF IL4 IL1A IGF1 ICAM1 GAPDH
50 inflammatory bowel disease 27.4 TP53 TNF TACR1 TAC1 IL4 IL1A

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to Keratopathy

Symptoms & Phenotypes for Keratopathy

MGI Mouse Phenotypes related to Keratopathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 ICAM1 IGF1 IL1A ITGB1 NID1 PAX6
2 immune system MP:0005387 10.06 AIRE ICAM1 IGF1 IL1A IL4 ITGB1
3 endocrine/exocrine gland MP:0005379 10.02 AIRE ICAM1 IGF1 IL4 ITGB1 JCHAIN
4 digestive/alimentary MP:0005381 10.01 AIRE ICAM1 IL4 ITGB1 JCHAIN PAX6
5 integument MP:0010771 10 ICAM1 IGF1 IL1A IL4 ITGB1 JCHAIN
6 neoplasm MP:0002006 9.81 AIRE CYP1B1 ICAM1 IGF1 IL1A ITGB1
7 respiratory system MP:0005388 9.56 AIRE IGF1 IL4 ITGB1 PAX6 TACR1
8 vision/eye MP:0005391 9.36 AIRE AKR1B1 CYP1B1 ICAM1 IL4 ITGB1

Drugs & Therapeutics for Keratopathy

Drugs for Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 91)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 2, Phase 3 51-84-3 187
2
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
3
Voriconazole Approved Phase 2, Phase 3 137234-62-9 71616
4
Natamycin Approved Phase 2, Phase 3 7681-93-8 5281099
5
Adalimumab Approved Phase 2, Phase 3 331731-18-1 16219006
6
Tacrolimus Approved, Investigational Phase 2, Phase 3 104987-11-3 445643 439492 6473866
7
Mycophenolic acid Approved Phase 2, Phase 3 24280-93-1 446541
8
Bevacizumab Approved, Investigational Phase 3 216974-75-3
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
10
Fluorouracil Approved Phase 3 51-21-8 3385
11
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
12 Pharmaceutical Solutions Phase 2, Phase 3
13 Ophthalmic Solutions Phase 2, Phase 3
14 abobotulinumtoxinA Phase 2, Phase 3
15 Acetylcholine Release Inhibitors Phase 2, Phase 3
16 Neurotransmitter Agents Phase 2, Phase 3
17 Cholinergic Agents Phase 2, Phase 3
18 Botulinum Toxins, Type A Phase 2, Phase 3
19 Neuromuscular Agents Phase 2, Phase 3
20 Botulinum Toxins Phase 2, Phase 3
21 Antifungal Agents Phase 2, Phase 3
22 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
23 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
24 Steroid Synthesis Inhibitors Phase 2, Phase 3
25 Anti-Infective Agents, Local Phase 2, Phase 3
26 Antirheumatic Agents Phase 2, Phase 3
27 Antibodies, Monoclonal Phase 2, Phase 3
28 Antibodies Phase 2, Phase 3
29 Immunoglobulins Phase 2, Phase 3
30 Anti-Bacterial Agents Phase 2, Phase 3
31 Antibiotics, Antitubercular Phase 2, Phase 3
32 Anti-Infective Agents Phase 2, Phase 3
33 Antitubercular Agents Phase 2, Phase 3
34 Calcineurin Inhibitors Phase 2, Phase 3
35 Angiogenesis Inhibitors Phase 3
36 Antineoplastic Agents, Immunological Phase 3
37 Immunosuppressive Agents Phase 3
38 Immunologic Factors Phase 3
39 HIV Protease Inhibitors Phase 3
40 Antiemetics Phase 3
41 Anti-Inflammatory Agents Phase 3
42 Gastrointestinal Agents Phase 3
43
protease inhibitors Phase 3
44 Antineoplastic Agents, Hormonal Phase 3
45 glucocorticoids Phase 3
46 BB 1101 Phase 3
47 Autonomic Agents Phase 3
48 Hormone Antagonists Phase 3
49 Antimetabolites Phase 3
50 Hormones Phase 3

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Topical Tacrolimus in Vernal Keratoconjunctivitis Unknown status NCT02456025 Phase 4 Topical tacrolimus
2 A Single-site, Open-Label Prospective Evaluation of Biocompatibility and Corneal Staining Associated With Use of Bausch & Lomb (B+L) BioTrue Contact Lens Multi-purpose Solution (MPS) and B+L PureVision Contact Lenses. Completed NCT01268306 Phase 4
3 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
4 Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis: a Prospective Randomized Double Masked Clinical Trial Unknown status NCT03230058 Phase 2, Phase 3 Group 1 Natamycin 5% Suspension + voriconazole 1% eye drops; Group 2 Natamycin 5% Suspension + Vehicle eye drops
5 The Silicone Study Completed NCT00000140 Phase 3 Perfluoropropane;Sulfur Hexafluoride;Silicone Oil
6 Evaluation of the Efficacy of Adalimumab for the Treatment of Uveitis in Juvenile Idiopathic Arthritis: Randomized Double-blind Placebo-controlled Trial Completed NCT01385826 Phase 2, Phase 3 Anti-tumor necrosis factor alpha monoclonal antibody;placebo
7 Phase 3, Multi-Center, Randomized, Double Masked, Placebo Controlled Clinical Study to Assess the Safety and Efficacy of RGN-259 Ophthalmic Solution for the Treatment of Neurotrophic Keratopathy: SEER-1 Recruiting NCT02600429 Phase 3 RGN-259;Placebo
8 Topical 0.03% Tacrolimus Versus Systemic Mycophenolate Mofetil for Preventing Graft Rejection After Repeat Keratoplasty: One-year Results of a Randomized Clinical Trial Recruiting NCT04147390 Phase 2, Phase 3 prescribe topical 0.03 % tacrolimus;prescribe mycophenolate mofetil(MMF)
9 The Use of Bevacizumab as a Modulator of Wound Healing Following Trabeculectomy Surgery: A Single Centre Randomised Controlled Phase III Pilot Study Active, not recruiting NCT02767219 Phase 3 bevacizumab;5-fluorouracil;Dexamethasone
10 Phase IIa Clinical Trial to Study the Feasability and Security of the Expanded Autologous Stem Cells (ASC) From Lipoaspirate in the Bilateral Limbic Associated Keratopathy Treatment Unknown status NCT01808378 Phase 2 Expanded adipose-derived stem cells
11 Comparative Analysis of Human Amniotic Membrane Graft Versus Contact Lenses in Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
12 Evaluation of the Pain and Visual Outcome Associated With Location of Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
13 Evaluation the Effect of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal Epithelium Healing (Phase I and II Clinical Trial) Completed NCT02746848 Phase 1, Phase 2
14 An Open Label, Pilot (Phase I/II), Dose-Escalation Safety and Tolerability Study of Combretastatin A4 Phosphate in Patients With Neovascular Age-Related Macular Degeneration. Completed NCT01570790 Phase 1, Phase 2 Combretastatin A-4 phosphate;Combretastatin A-4 Phosphate;Combretastatin A-4 Phosphate
15 Effects of Oral Mucolytics on Tear Film and Ocular Surface Completed NCT01713179 Phase 1, Phase 2 Ambroxol hydrochloride (Mucopect®, 60 mg, Boehringer Ingelheim)
16 Long-Term Clinical Trial of Nitisinone in Alkaptonuria Completed NCT00107783 Phase 2 Nitisinone (NTBC)
17 A Multicenter, Randomized, Open-label, Two-arms Phase I/II Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Recruiting NCT03084861 Phase 1, Phase 2 Cord Blood Eye Drops;Conventional treatment
18 Safety and Feasibility of Cultivated Autologous Limbal Epithelial Cell Transplantation in the Treatment of Limbal Stem Cell Deficiency (LSCD) Recruiting NCT02592330 Phase 1, Phase 2
19 A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) Patients Terminated NCT01972438 Phase 2 ASEDs;Saline
20 A First-in-human Phase 1 Dose Escalation Study of SAR428926 in Patients With Advanced Solid Tumors Completed NCT02575781 Phase 1 SAR428926
21 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection Completed NCT02068430 Phase 1 Riboflavin 0.1%
22 Phase 1 Clinical Study to Evaluate Safety and Tolerability of Magnetic Human Corneal Endothelial Cells in the Treatment of Corneal Edema Recruiting NCT04191629 Phase 1
23 Blood Based Eyedrops From Different Sources in the Treatment of Severe Keratopathy - A Randomized Clinical Trial Unknown status NCT03064984
24 Comparison of Aqueous and Plasma Glucose Level in Diabetic Patients Unknown status NCT02750098
25 Corneal Transplantation Guided by OCT RESCAN: Pre-op, Intra-op and Post-op Evaluation Unknown status NCT02736877
26 Prospective, Randomized Crossover Study Of The Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 saline solution
27 Study of the Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking Completed NCT01106274
28 Amniotic Membrane and Anterior Stromal Puncture: a Comparative Study in the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308
29 Amniotic Membrane Transplant in Symptomatic Bullous Keratopathy Patients: Confocal Microscopy & AS-OCT Long Term Results Completed NCT03450954
30 Eyelash Line Resection for Entropion Associated With Down's Syndrome Completed NCT01758718
31 Study of Automated Lamellar Keratectomy With a New Option in Treatment in Symptomatic Patients With Bullous Keratopathy. Completed NCT00654888 Mitomycin
32 The Influences of Dry Eye Disease on Optical Quality Completed NCT04043949
33 Randomised Trial Comparing the Efficacy of Ocular Lubricant (Lacrilube) and Polyacrylamide Hydrogel Dressing (Geliperm) for the Prevention of Exposure Keratopathy in the Critically Ill Completed NCT00513734
34 The Application of Subconjunctival Injection of Bevacizumab (Avastin) in the Treatment of Corneal Neovasculization Completed NCT00681603 subconjunctival injection of bevacizumab ( 1.25 to 2.50 mg)
35 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
36 Measurement of the Retinal Oxygen Saturaiton After Long-term Silicon Oil Tamponade With Oxymap Completed NCT02423382
37 Long-term Results of Topical Cyclosporine 0.05% in the Treatment of Atopic Keratoconjunctivitis Completed NCT00987467 Cyclosporin 0.05% ophthalmic
38 Prospective, Randomized Crossover Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Completed NCT02660151 Salt solution
39 Phenotype-Genotype Correlation in Aniridia Completed NCT00265590
40 Emulsification of Different Viscosity Silicone Oil After Complicated Retinal Detachment Surgery: A Randomized Double-masked Clinical Trial Completed NCT02988583
41 Clinical Comparison of Two Anesthetic Preparations for Intravitreal Injection Completed NCT01087489 4% lidocaine;3.5% ophthalmic lidocaine gel
42 Establishment of Biomarkers for Fabry Disease Completed NCT01165697
43 To Investigate the Precision and Agreement of SS-1000 and the Predicate Device Pentacam in a Repeatability and Reproducibility Trial (PASP) Completed NCT02077790
44 Zhongshan Ophthalmic Center, Sun Yat-Sen University,China Recruiting NCT03447041
45 Prospective, Randomized Multi-Center Study of Using the Hyper-CL™ Lens in Subjects Suffering From Bacterial Keratitis Recruiting NCT03845374
46 The Marker Expression of Corneal Surface From Penetrating Keratopathy After Collagenase A Assisted COMET Case Series Recruiting NCT04066439
47 Biomarker for Cystinosis Disease AN INTERNATIONAL, MULTICENTER, EPIDEMIOLOGICAL PROTOCOL Recruiting NCT02837523
48 An Open-label, Pilot Study to Assess the Safety, Tolerability and Preliminary Efficacy of EDTA Eye Drops on Band Keratopathy Not yet recruiting NCT03985371 Early Phase 1 EDTA Eye Drops
49 Keratoconus, Corneal Diseases and Transplant Registry (KCDTR) Not yet recruiting NCT04164407

Search NIH Clinical Center for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

Anatomical Context for Keratopathy

MalaCards organs/tissues related to Keratopathy:

40
Endothelial, Eye, Thyroid, Skin, Breast, T Cells, Brain

Publications for Keratopathy

Articles related to Keratopathy:

(show top 50) (show all 3857)
# Title Authors PMID Year
1
SEVERE CASE OF RENAL COLOBOMA SYNDROME IN LONG-TERM FOLLOW-UP. 61
28820764 2020
2
Severe Ocular Complications After Blepharoptosis Correction in the Oculopharyngeal Muscular Dystrophy Patient: Literature Review and Case Presentation. 61
31833892 2020
3
Densitometry Analysis of Corneal Backscatter After Pre-Descemet Endothelial Keratoplasty for Pseudophakic Bullous Keratopathy. 61
31498248 2020
4
Graft Survival After Penetrating and Endothelial Keratoplasty in Iridocorneal Endothelial Syndrome. 61
31335531 2020
5
Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation. 61
31852464 2019
6
Current Understanding of the Progression and Management of Thyroid Associated Orbitopathy: A Systematic Review. 61
31823232 2019
7
Fulminant Sphingomonas paucimobilis keratitis: case study and review of literature. 61
31801779 2019
8
Management of Nocardia Interface Keratitis After Descemet Membrane Endothelial Keratoplasty. 61
31306288 2019
9
Case Reports for Topical Treatment of Corneal Ulcers with a New Matrix Therapy Agent or RGTA® in Dogs. 61
31847217 2019
10
An update on the modern management of paediatric uveitis. 61
31272956 2019
11
Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation. 61
30770356 2019
12
Fire Ant Punctate Keratopathy: A Novel Diagnosis Based on Clinical and Anterior Segment Optical Coherence Tomography Findings. 61
31567629 2019
13
Reporting outcomes of hyaluronic gel filler as a treatment for epiblepharon. 61
31641882 2019
14
Clinical Evaluation of the "Lifeline Suture" Technique for DSAEK in Cases Without Posterior Capsule Using a Novel Donor Insertion Device. 61
31809287 2019
15
Ocular Surface Disease in a PICU: Incidence and Outcomes With a Dynamic Eye Care Protocol. 61
31834245 2019
16
Epipremnum aureum Keratopathy: Case Report and Review of the Literature. 61
31794541 2019
17
Recent innovations with drugs in clinical trials for neurotrophic keratitis and refractory corneal ulcers. 61
31596151 2019
18
Management of Congenital Aniridia-Associated Keratopathy: Long-Term Outcomes from a Tertiary Referral Center. 61
31730836 2019
19
Early phenotypic features of aniridia-associated keratopathy and association with PAX6 coding mutations. 61
31734509 2019
20
Ophthalmological management in craniosynostosis. 61
31574284 2019
21
Comparative study of penetrating keratoplasty and vitreoretinal surgery with Eckardt temporary keratoprosthesis in ocular trauma versus non-trauma patients. 61
31363832 2019
22
MSCs helped reduce scarring in the cornea after fungal infection when combined with anti-fungal treatment. 61
31727008 2019
23
Review of Laser Vision Correction (LASIK, PRK and SMILE) with Simultaneous Accelerated Corneal Crosslinking - Long-term Results. 61
31411927 2019
24
In Vivo Confocal Microscopy of Prominent Conjunctival and Corneal Nerves in Multiple Endocrine Neoplasia Type 2B. 61
31205161 2019
25
Predictability of intraocular lens power calculation in eyes after phototherapeutic keratectomy. 61
31691031 2019
26
Paraproteinemic keratopathy associated with monoclonal gammopathy of undetermined significance (MGUS): clinical findings in twelve patients including recurrence after keratoplasty. 61
31044553 2019
27
Long noncoding RNA KCNQ1OT1 induces pyroptosis in diabetic corneal endothelial keratopathy 61
31693400 2019
28
Graft Versus Host Disease-Associated Dry Eye: Role of Ocular Surface Mucins and the Effect of Rebamipide, a Mucin Secretagogue. 61
31675422 2019
29
Corneal nerves in health and disease. 61
31075321 2019
30
Nerve growth factor in dogs: Assessment of two immunoassays and selected ocular parameters following a nicergoline challenge per os. 61
31774231 2019
31
Once in a blue moon: Lipid keratopathy and intrastromal hemorrhage in a Mission golden-eyed tree frog (Trachycephalus resinifictrix). 61
31733050 2019
32
Blood derived treatment from two allogeneic sources for severe dry eye associated to keratopathy: a multicentre randomised cross over clinical trial. 61
31744796 2019
33
Microsporidial keratopathy in two dogs. 61
31758652 2019
34
Cenegermin in Pediatric Neurotrophic Keratopathy. 61
31403527 2019
35
Herpetic Corneal Keratopathy Management Using Ipsilateral Supratrochlear Nerve Transfer for Corneal Neurotization. 61
31609805 2019
36
Does Preoperative or Postoperative Graft Thickness Influence Postoperative Visual Acuity in Descemet Stripping Automated Endothelial Keratoplasty for Advanced Pseudophakic Bullous Keratopathy? 61
31436644 2019
37
Descemet Membrane Endothelial Keratoplasty Versus Descemet Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty. 61
31228467 2019
38
Comparison of 5-Year Clinical Results of Descemet and Non-Descemet Stripping Automated Endothelial Keratoplasty. 61
31789922 2019
39
Suprachoroidal Hemorrhage During Descemet Membrane Endothelial Keratoplasty. 61
31714406 2019
40
NS Endo-Inserter: A New Graft Inserter for Descemet Stripping Automated Endothelial Keratoplasty. 61
31403531 2019
41
Risk Factors for the Development of Ocular Hypertension After Keratoplasty: A Systematic Review. 61
31764288 2019
42
Corneal vortex keratopathy in childhood-onset systemic lupus erythematosus (c-SLE). 61
31190285 2019
43
Ophthalmic Manifestation of Tsukamurella Species: A Case Series and First Report of Ocular Implant Infection After Enucleation. 61
31246677 2019
44
Association of apoptosis genes in PDCD1 but not PDCD1LG2, FAS, and FASLG with pediatric idiopathic uveitis in Han Chinese. 61
31618754 2019
45
Outcomes of strabismus surgery in genetically confirmed congenital fibrosis of the extraocular muscles. 61
31541710 2019
46
Neurotrophic keratopathy: Pros and cons of current treatments. 61
31526824 2019
47
Management of ocular manifestations of autosomal recessive congenital ichthyosis 4B, harlequin type, in the perinatal period. 61
31586585 2019
48
Glaucoma Drainage Devices and Reasons For Keratoplasty. 61
31393312 2019
49
Primary Bullous Keratopathy in a Patient With Werner Syndrome Treated With Corneal Transplant. 61
29534662 2019
50
Fabry keratopathy: manifestations and changes over time. 61
31666224 2019

Variations for Keratopathy

Expression for Keratopathy

Search GEO for disease gene expression data for Keratopathy.

Pathways for Keratopathy

Pathways related to Keratopathy according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 TP53 TNF PAX6 OGFR ITGB1 IL4
2
Show member pathways
13.45 TP53 TNF OGFR ITGB1 IL4 IL1A
3
Show member pathways
13.3 TP53 TNF ITGB1 IL4 IL1A ICAM1
4 12.79 TP53 ITGB1 IL4 IGF1 CXCL8
5
Show member pathways
12.79 TNF IL4 IL1A ICAM1 CXCL8
6
Show member pathways
12.76 TP53 TNF IL1A ICAM1 CXCL8
7 12.31 TP53 TNF ITGB1 CXCL8
8
Show member pathways
12.26 TP53 TNF IL1A CXCL8
9
Show member pathways
12.26 TP53 TNF IL4 ICAM1
10 12.23 TP53 TNF ITGB1 IGF1
11 12.22 TNF ITGB1 GAPDH CXCL8
12
Show member pathways
12.18 TNF ITGB1 IL4 IL1A
13
Show member pathways
12.08 TP53 TNF OGFR IL4 IL1A IGF1
14 12.01 TP53 TNF IL1A ICAM1
15 11.94 TNF TACR1 TAC1 IL1A GAPDH CXCL8
16 11.85 TP53 IL1A IGF1 CXCL8
17 11.81 TNF IL1A ICAM1 CXCL8
18 11.76 TNF IL1A ICAM1 CXCL8
19
Show member pathways
11.69 TNF IL4 CXCL8
20 11.69 TP53 IL4 ICAM1 CXCL8
21 11.66 TNF IL4 IGF1
22 11.64 TNF ITGB1 IL1A CXCL8
23 11.58 TP53 TNF TACR1 IL4 IL1A ICAM1
24
Show member pathways
11.53 TNF IL1A ICAM1 CXCL8
25 11.5 TNF IL4 IGF1 CXCL8
26 11.47 TNF ICAM1 CXCL8
27 11.45 NID1 ITGB1 IGF1 CXCL8
28 11.41 TNF IL1A IGF1
29 11.4 ITGB1 ICAM1 CXCL8
30 11.24 TNF IL4 IL1A ICAM1 CXCL8
31 11.22 TP53 TNF ITGB1 IL4 IL1A ICAM1
32 11.17 TNF IL4 IL1A
33 10.93 TNF ITGB1 IL4 IL1A IGF1 CXCL8
34 10.45 TACR1 TAC1

GO Terms for Keratopathy

Cellular components related to Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 TNF TAC1 NID1 LACRT JCHAIN IL4
2 cell GO:0005623 9.5 TP53 TACR1 TAC1 PAX6 LACRT ITGB1
3 extracellular space GO:0005615 9.32 TNF TAC1 LACRT JCHAIN IL4 IL1A

Biological processes related to Keratopathy according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.09 TP53 TNF PAX6 IL4 IL1A IGF1
2 negative regulation of cell proliferation GO:0008285 9.97 TP53 PAX6 IL1A CYP1B1 CXCL8
3 positive regulation of transcription, DNA-templated GO:0045893 9.95 TP53 TNF PAX6 IL4 IGF1 AIRE
4 extracellular matrix organization GO:0030198 9.89 TNF NID1 ITGB1 ICAM1
5 inflammatory response GO:0006954 9.89 TNF TACR1 TAC1 IL1A CXCL8
6 immune response GO:0006955 9.88 TNF JCHAIN IL4 IL1A CXCL8 AIRE
7 leukocyte migration GO:0050900 9.84 TNF JCHAIN ITGB1 ICAM1
8 cellular response to lipopolysaccharide GO:0071222 9.81 TNF IL1A ICAM1 CXCL8
9 positive regulation of angiogenesis GO:0045766 9.76 ITGB1 IL1A CYP1B1 CXCL8
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.75 TNF IL4 IGF1
11 positive regulation of gene expression GO:0010628 9.73 TP53 TNF PAX6 IL4 IL1A IGF1
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.7 TNF IGF1 AKR1B1
13 negative regulation of neuroinflammatory response GO:0150079 9.61 IL4 IGF1
14 positive regulation of protein oligomerization GO:0032461 9.6 TP53 JCHAIN
15 response to salt stress GO:0009651 9.58 TP53 TNF
16 tachykinin receptor signaling pathway GO:0007217 9.56 TACR1 TAC1
17 positive regulation of JAK-STAT cascade GO:0046427 9.54 TNF CYP1B1 AKR1B1
18 positive regulation of cytokine secretion GO:0050715 9.5 TNF IL1A GAPDH
19 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.46 TP53 LACRT IGF1 ICAM1
20 detection of abiotic stimulus GO:0009582 9.43 TACR1 TAC1
21 cytokine-mediated signaling pathway GO:0019221 9.17 TP53 TNF ITGB1 IL4 IL1A ICAM1
22 positive regulation of calcineurin-NFAT signaling cascade GO:0070886 9.13 TNF LACRT IGF1

Molecular functions related to Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.46 TP53 TNF PAX6 AIRE
2 cytokine activity GO:0005125 9.26 TNF IL4 IL1A CXCL8
3 laminin-1 binding GO:0043237 8.62 NID1 LACRT

Sources for Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
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50 NDF-RT
53 NINDS
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56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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