Aliases & Classifications for Keratopathy

MalaCards integrated aliases for Keratopathy:

Name: Keratopathy 39 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2283
NCIt 51 C27012
UMLS 74 C0235270

Summaries for Keratopathy

MalaCards based summary : Keratopathy is related to bullous keratopathy and limbal stem cell deficiency. An important gene associated with Keratopathy is PAX6 (Paired Box 6), and among its related pathways/superpathways are Degradation of the extracellular matrix and G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins. The drugs Pharmaceutical Solutions and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and breast, and related phenotypes are homeostasis/metabolism and behavior/neurological

Related Diseases for Keratopathy

Diseases related to Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 bullous keratopathy 33.4 BMP4 FBN1 IL1A NID1 TNC
2 limbal stem cell deficiency 29.5 IL1A KRT12 VCAM1
3 microvascular complications of diabetes 5 28.9 AKR1B1 IGF1 VCAM1
4 thygeson superficial punctate keratopathy 12.3
5 neurotrophic keratopathy 12.2
6 climatic droplet keratopathy 12.2
7 corneal dystrophy, band-shaped 11.8
8 schnyder corneal dystrophy 11.1
9 palmoplantar carcinoma, multiple self-healing 11.1
10 corneal degeneration, ribbonlike, with deafness 11.1
11 cataract 10.3
12 myeloma, multiple 10.2
13 lagophthalmos 10.2
14 char syndrome 10.2 BMP4 FBN1
15 autoimmune addison disease 10.1 AIRE NLRP1
16 aniridia 1 10.1
17 monoclonal gammopathy of uncertain significance 10.1
18 cryptosporidiosis 10.1 IL1A TAC1
19 corneal dystrophy, fuchs endothelial, 1 10.1
20 keratoconus 10.1
21 fuchs' endothelial dystrophy 10.1
22 uveitis 10.1
23 axenfeld-rieger syndrome, type 1 10.1 BMP4 PAX6
24 arthritis 10.1
25 corneal neovascularization 10.1
26 herpes zoster 10.1
27 amyloidosis 10.1
28 goodpasture syndrome 10.0 NID1 VCAM1
29 sebaceous gland disease 10.0 IGF1 IL1A
30 rheumatoid arthritis 10.0
31 alkaptonuria 10.0
32 fabry disease 10.0
33 ptosis 10.0
34 herpes simplex 10.0
35 vitiligo-associated multiple autoimmune disease susceptibility 1 10.0 AIRE NLRP1
36 somatoform disorder 10.0 IL1A TAC1
37 retinal detachment 10.0
38 crohn's disease 10.0
39 diabetes mellitus 10.0
40 corneal disease 10.0
41 corneal edema 10.0
42 oral lichen planus 9.9 IL1A VCAM1
43 strabismus 9.9
44 astigmatism 9.9
45 kawasaki disease 9.9
46 sleep apnea 9.9
47 lymphoma 9.9
48 xerophthalmia 9.9
49 cystinosis 9.9
50 keratomalacia 9.9

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to Keratopathy

Symptoms & Phenotypes for Keratopathy

MGI Mouse Phenotypes related to Keratopathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 AIRE AKR1B1 BMP4 FBN1 IGF1 IL1A
2 behavior/neurological MP:0005386 10.03 AIRE AKR1B1 BMP4 FBN1 NID1 PAX6
3 cardiovascular system MP:0005385 10.01 BMP4 FBN1 IGF1 IL1A NID1 PAX6
4 integument MP:0010771 9.8 BMP4 FBN1 IGF1 IL1A PAX6 TAC1
5 no phenotypic analysis MP:0003012 9.73 AIRE BMP4 FBN1 KRT12 TNC VCAM1
6 normal MP:0002873 9.7 AIRE BMP4 IGF1 KRT12 PAX6 TAC1
7 renal/urinary system MP:0005367 9.43 AKR1B1 BMP4 FBN1 IGF1 PAX6 TAC1
8 vision/eye MP:0005391 9.1 AIRE AKR1B1 BMP4 KRT12 NID1 PAX6

Drugs & Therapeutics for Keratopathy

Drugs for Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 105)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
2
Acetylcholine Approved, Investigational Phase 2, Phase 3 51-84-3 187
3
chloroquine Approved, Investigational, Vet_approved Phase 3,Phase 2 54-05-7 2719
4
Primaquine Approved Phase 3,Phase 2 90-34-6 4908
5
Tafenoquine Approved, Investigational Phase 3,Phase 2,Phase 1 106635-80-7
6 Orange Approved Phase 3
7 Neurotransmitter Agents Phase 2, Phase 3
8 Cholinergic Agents Phase 2, Phase 3
9 Acetylcholine Release Inhibitors Phase 2, Phase 3
10 abobotulinumtoxinA Phase 2, Phase 3
11 Botulinum Toxins, Type A Phase 2, Phase 3
12 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3,Not Applicable
13 Botulinum Toxins Phase 2, Phase 3
14 Neuromuscular Agents Phase 2, Phase 3
15 Ophthalmic Solutions Phase 3,Phase 1,Phase 2,Not Applicable
16 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
17 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2
18 Antiparasitic Agents Phase 3,Phase 2,Phase 1
19 Analgesics, Non-Narcotic Phase 3,Phase 2
20 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
21 Anthelmintics Phase 3,Phase 2
22 Antiprotozoal Agents Phase 3,Phase 2,Phase 1
23 Analgesics Phase 3,Phase 2
24 Antimalarials Phase 3,Phase 2,Phase 1
25 Antirheumatic Agents Phase 3,Phase 2,Not Applicable
26 Chloroquine diphosphate Phase 3,Phase 2 50-63-5
27
Bevacizumab Approved, Investigational Phase 2,Not Applicable 216974-75-3
28
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
29
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
30
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
31
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
32
Fluorometholone Approved, Investigational Phase 2,Not Applicable 426-13-1 9878
33
Miconazole Approved, Investigational, Vet_approved Phase 2,Not Applicable 22916-47-8 4189
34
Loteprednol Approved, Experimental Phase 2 82034-46-6, 129260-79-3 444025 9865442
35
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
36
Ambroxol Investigational Phase 1, Phase 2 18683-91-5
37 Antineoplastic Agents, Immunological Phase 2,Not Applicable
38 Angiogenesis Inhibitors Phase 2,Not Applicable
39 Antibodies, Monoclonal Phase 2
40 Antibodies Phase 2
41 Endothelial Growth Factors Phase 2
42 Immunoglobulins Phase 2
43 Angiogenesis Modulating Agents Phase 2,Not Applicable
44 Mitogens Phase 2
45 Anesthetics Phase 2,Not Applicable
46 Neuroprotective Agents Phase 2
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Not Applicable
48 Anti-Allergic Agents Phase 2
49 Protective Agents Phase 2,Not Applicable
50 glucocorticoids Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 Study of the Presence and Extent of Corneal Disturbance Associated With B+L Biotrue MPS Used With B+L PureVision Lenses Completed NCT01268306 Phase 4
2 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
3 Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria Completed NCT02216123 Phase 3 Tafenoquine;Tafenoquine Placebo;Chloroquine;Primaquine;Primaquine Placebo
4 Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1 Recruiting NCT02600429 Phase 3 RGN-259;Placebo
5 Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation Active, not recruiting NCT03248037 Phase 3 Netarsudil;Placebo
6 Stem Cells Treatment for Bilateral Limbic Associated Keratopathy (HULPOFT) Unknown status NCT01808378 Phase 2 Expanded adipose-derived stem cells
7 Bevacizumab for the Treatment of Corneal Neovascularization Unknown status NCT00992849 Phase 2 Bevacizumab
8 Amniotic Membrane Graft In Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
9 Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK) Completed NCT01448213 Phase 2 Prednisolone acetate;Fluorometholone
10 Study Evaluating Efficacy and Safety of SAR566658 Treatment in Patients With CA6 Positive Metastatic Triple Negative Breast Cancer Completed NCT02984683 Phase 2 SAR566658 (ACT14884)
11 Utilization of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal Healing Completed NCT02746848 Phase 1, Phase 2
12 Pain and Visual Outcome in Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
13 Effects of Oral Mucolytics on Tear Film and Ocular Surface Completed NCT01713179 Phase 1, Phase 2 Ambroxol hydrochloride (Mucopect®, 60 mg, Boehringer Ingelheim)
14 Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapse Completed NCT01376167 Phase 2 Chloroquine 600mg;Chloroquine 300mg;Tafenoquine 50mg;Tafenoquine 100mg;Tafenoquine 300mg;Tafenoquine 600mg;Primaquine 15mg;Chloroquine 600mg (Part 2 );Chloroquine 300mg (Part 2 );Tafenoquine 300mg (Part 2);Primaquine 15mg (Part2 )
15 An Extension to Study MD7108240 Completed NCT00733304 Phase 2 Pazopanib
16 Lotemax® Gel 0.5% and Restasis 0.05% in Subjects With Mild or Moderate Keratoconjunctivitis Sicca Completed NCT01817582 Phase 2 Lotemax Gel + Restasis;Lotemax Gel;Restasis
17 A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Recruiting NCT03084861 Phase 1, Phase 2 Cord Blood Eye Drops;Conventional treatment
18 Study of Ataluren in Participants With Nonsense Mutation Aniridia Active, not recruiting NCT02647359 Phase 2 Ataluren;Placebo
19 A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) Patients Terminated NCT01972438 Phase 2 ASEDs;Saline
20 A Study of SAR428926 in Patients With Advanced Solid Tumors Completed NCT02575781 Phase 1 SAR428926
21 Assessment of Any Potential Retinal Effects of Tafenoquine (TQ) Completed NCT02658435 Phase 1 Tafenoquine 150 mg;Matched placebo 150mg
22 Blood Based Eyedrops From Different Sources in the Treatment of Severe Keratopathy Unknown status NCT03064984 Not Applicable
23 Corneal Transplantation Guided by OCT RESCAN Unknown status NCT02736877 Not Applicable
24 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584 Not Applicable
25 Comparing Endoglide to Endoserter for DSAEK Graft Insertion Unknown status NCT01791075 Not Applicable
26 Staged and Combined Surgery for Cataract Patients With Corneal Endothelial Dysfunction Unknown status NCT02523950 Not Applicable
27 Comparison of Aqueous and Plasma Glucose Level in Diabetic Patients Unknown status NCT02750098 Not Applicable
28 Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 Not Applicable saline solution
29 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044 Not Applicable
30 Long Term Results of Amniotic Membrane Transplant in Bullous Keratopathy Patients Completed NCT03450954
31 Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308 Not Applicable
32 The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous Keratopathy Completed NCT01106274 Not Applicable
33 Automated Lamellar Keratectomy in Symptomatic Patients With Bullous Keratopathy Completed NCT00654888 Not Applicable Mitomycin
34 Eyelash Line Resection for Entropion Associated With Down's Syndrome Completed NCT01758718 Not Applicable
35 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
36 A Comparison of Hydrogel Dressings and Ocular Lubricants in the Prevention on Corneal Damage in the Critically Ill Completed NCT00513734 Not Applicable
37 Safety and Effectiveness of Subconjunctival Injection of Bevacizumab in the Treatment of Corneal Neovasculization Completed NCT00681603 Not Applicable subconjunctival injection of bevacizumab ( 1.25 to 2.50 mg)
38 Comparison of Patient Comfort After Two Anesthetic Protocols for Injections Into the Eye Completed NCT01087489 Not Applicable 4% lidocaine;3.5% ophthalmic lidocaine gel
39 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467 Not Applicable Cyclosporin 0.05% ophthalmic
40 Study of Endothelial Keratoplasty Outcomes Completed NCT00800111 Not Applicable
41 Evaluation of Dry Eye and Meibomian Gland Dysfunction After Cataract Surgery Completed NCT01942642
42 Corneal WFG Versus AF Trans PRK in Myopic Patients With High Corneal HOA Completed NCT03786861 Not Applicable
43 Correlation of Gene Abnormalities and Clinical Manifestations of Aniridia Completed NCT00265590
44 Visual Quality and Contrast Sensitivity Function After Corneal Transplantation Recruiting NCT03447041
45 Air Versus SF6 for Descemet's Membrane Endothelial Keratoplasty (DMEK) Recruiting NCT03407755 Not Applicable
46 Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Recruiting NCT02660151 Not Applicable Salt solution
47 The ADVISE Study: Advanced Visualization In Corneal Surgery Evaluation Recruiting NCT03763721 Not Applicable
48 Evaluating Medium-chain Triglycerides as a Temporary Intraocular Tamponading Agent for Retinal Detachment Recruiting NCT03855462 Not Applicable
49 Sjögren's Syndrome Is Associated With Meibomian Gland Dysfunction Recruiting NCT03434106 Not Applicable liposic;Tears Naturale Forte
50 Is Sjögren's Syndrome Associated With Meibomian Gland Dysfunction ? Recruiting NCT03060005 Not Applicable Tears Naturale Forte;liposic

Search NIH Clinical Center for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

Anatomical Context for Keratopathy

MalaCards organs/tissues related to Keratopathy:

42
Endothelial, Eye, Breast, Thyroid, Brain, Testes, Skin

Publications for Keratopathy

Articles related to Keratopathy:

(show top 50) (show all 1074)
# Title Authors Year
1
Treatment of corneal neovascularization with topical aflibercept in a case of exposure keratopathy following cerebellar astrocytoma surgery. ( 30574927 )
2019
2
Cytokine Levels in the Aqueous Humor Are Associated With Corneal Thickness in Eyes With Bullous Keratopathy. ( 30316668 )
2019
3
Effect of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy. ( 30783940 )
2019
4
Triple procedure for pseudophakic bullous keratopathy in complicated cataract surgery: Glued IOL with single-pass four-throw pupilloplasty with pre-Descemet's endothelial keratoplasty. ( 30819560 )
2019
5
Different graft thicknesses after Descemet stripping endothelial keratoplasty for bullous keratopathy in the two eyes of the same patient. ( 30881147 )
2019
6
Meibomian gland dysfunction and keratopathy are associated with dry eye disease in aniridia. ( 29519880 )
2019
7
In vivo microscopic and optical coherence tomography classification of neurotrophic keratopathy. ( 30240004 )
2019
8
In vivo confocal microscopy of multiple myeloma associated crystalline keratopathy. ( 30561166 )
2019
9
Characterization of corneal deposition keratopathy in the setting of blood cell dyscrasia and a minimally invasive technique to clear the cornea in a single case. ( 30619968 )
2019
10
Fluocinolone acetonide intravitreal implant as a therapeutic option for severe Sjögren's syndrome-related keratopathy: a case report. ( 30674351 )
2019
11
Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy. ( 30679185 )
2019
12
Polyquaternium-1-Associated Dendritiform Keratopathy. ( 30702469 )
2019
13
Central Toxic Keratopathy After Contact Lens Wear and Mechanical Debridement: Clinical Characteristics, and Visual and Corneal Tomographic Outcomes. ( 30707128 )
2019
14
Medial canthoplasty for the management of exposure keratopathy. ( 30710111 )
2019
15
Post-herpes neurotrophic keratopathy: Aetiopathogenesis, clinical signs and current therapies. ( 30718014 )
2019
16
Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation. ( 30770356 )
2019
17
A Case of Neurotrophic Keratopathy Associated with Nasopharyngeal Carcinoma. ( 29643792 )
2018
18
Pigmentary keratopathy in a child: Histopathologic analysis. ( 29370944 )
2018
19
A hybrid technique to address exposure keratopathy secondary to facial nerve paresis: A combination of a lateral tarsorrhaphy and lateral wedge resection. ( 29776684 )
2018
20
Primary Bullous Keratopathy in a Patient With Werner Syndrome Treated With Corneal Transplant. ( 29534662 )
2018
21
Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy. ( 29539291 )
2018
22
Primary Descemet's Membrane Endothelial Keratoplasty for Fuchs Endothelial Dystrophy versus Bullous Keratopathy: Histopathology and Clinical Results. ( 29939775 )
2018
23
Clinical and Histological Characterization of Toxic Keratopathy From Depatuxizumab Mafodotin (ABT-414), an Antibody-Drug Conjugate. ( 29794826 )
2018
24
Modeling of Aniridia-Related Keratopathy by CRISPR/Cas9 Genome Editing of Human Limbal Epithelial Cells and Rescue by Recombinant PAX6 Protein. ( 29808941 )
2018
25
Pediatric primary calcific band keratopathy with or without glaucoma from biallelic SLC4A4 mutations. ( 29671668 )
2018
26
Human corneal endothelial cell transplantation using nanocomposite gel sheet in bullous keratopathy. ( 29531856 )
2018
27
Cerebellar Ataxia With Neuropathy and Vestibular Areflexia Syndrome Presenting With Neurotrophic Keratopathy. ( 29474200 )
2018
28
Corneal Neurotization for Neurotrophic Keratopathy: Clinical Outcomes and In Vivo Confocal Microscopic and Histopathological Findings. ( 29373338 )
2018
29
Incidence, risk factors and impact of protocolised care on exposure keratopathy in critically ill adults: a two-phase prospective cohort study. ( 29338772 )
2018
30
Painless bilateral bullous keratopathy. ( 29573998 )
2018
31
Use of an Ocular Wound Chamber for the Prevention of Exposure Keratopathy in a Guinea Pig Model. ( 29943888 )
2018
32
Inhibition of Soluble Epoxide Hydrolase 2 Ameliorates Diabetic Keratopathy and Impaired Wound Healing in Mouse Corneas. ( 29615440 )
2018
33
Management of <i>Candida glabrata</i> infectious crystalline keratopathy with endophthalmitis following penetrating keratoplasty. ( 29941758 )
2018
34
Topical ganciclovir treatment post-Descemet's stripping automated endothelial keratoplasty for patients with bullous keratopathy induced by cytomegalovirus. ( 29363530 )
2018
35
Dry eye and meibomian gland dysfunction in pseudophakic bullous keratopathy. ( 29392636 )
2018
36
Stage-related central corneal epithelial transformation in congenital aniridia-associated keratopathy. ( 29133179 )
2018
37
Wheel Spokes Technique for Endothelial Keratoplasty for Extremely Mydriatic Bullous Keratopathy Eyes without Capsular Support. ( 29681843 )
2018
38
Neurotrophic Keratopathy after Trigeminal Nerve Block for Treatment of Postherpetic Neuralgia. ( 29955409 )
2018
39
A Case of Neurotrophic Keratopathy Concomitant to Brain Metastasis. ( 29755905 )
2018
40
In Vivo Confocal Microscopy Reveals Corneal Reinnervation After Treatment of Neurotrophic Keratopathy With Corneal Neurotization. ( 29053558 )
2018
41
<i>In Vivo</i> Confocal Microscopic Observations of Vortex Keratopathy in Patients with Amiodarone-Induced Keratopathy and Fabry Disease. ( 29750121 )
2018
42
Vitamin B12 Deficiency as a Cause of Neurotrophic Keratopathy. ( 29541277 )
2018
43
In Vivo Confocal Microscopic Study of Hard Contact Lens-Induced Lipid Keratopathy Secondary to Corneal Neovascularization in a Rabbit Hypercholesterolemic Model. ( 29489496 )
2018
44
Endothelial cell loss and graft survival after penetrating keratoplasty for laser iridotomy-induced bullous keratopathy. ( 29766356 )
2018
45
Atypical Presentation of Iridocorneal Endothelial Syndrome With Band Keratopathy but No Corneal Edema Managed With Descemet Membrane Endothelial Keratoplasty. ( 29668572 )
2018
46
Corneal Abnormalities in Congenital Aniridia: Congenital Central Corneal Opacity Versus Aniridia-associated Keratopathy. ( 29101006 )
2018
47
EDTA chelation for symptomatic band keratopathy: results and recurrence. ( 29192681 )
2018
48
Bilateral bullous keratopathy secondary to melting keratitis in a Suri alpaca (<i>Vicugna pacos</i>). ( 29636928 )
2018
49
Neurotrophic keratopathy. ( 29698813 )
2018
50
Superficial punctate keratopathy in a pediatric patient was related to adenoid hypertrophy and obstructive sleep apnea syndrome: a case report. ( 29471795 )
2018

Variations for Keratopathy

Expression for Keratopathy

Search GEO for disease gene expression data for Keratopathy.

Pathways for Keratopathy

GO Terms for Keratopathy

Cellular components related to Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 BMP4 FBN1 IGF1 IL1A NID1 TAC1
2 extracellular space GO:0005615 9.23 AKR1B1 BMP4 FBN1 IGF1 IL1A TAC1
3 basement membrane GO:0005604 9.13 FBN1 NID1 TNC

Biological processes related to Keratopathy according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.95 AIRE BMP4 IGF1 IL1A PAX6
2 regulation of signaling receptor activity GO:0010469 9.76 BMP4 FBN1 IGF1 IL1A
3 regulation of gene expression GO:0010468 9.74 BMP4 IGF1 PAX6
4 skeletal system development GO:0001501 9.61 BMP4 FBN1 IGF1
5 positive regulation of protein secretion GO:0050714 9.58 IGF1 IL1A
6 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.56 BMP4 IGF1
7 cellular protein metabolic process GO:0044267 9.56 BMP4 FBN1 IGF1 TNC
8 metanephros development GO:0001656 9.54 BMP4 FBN1
9 neuron fate commitment GO:0048663 9.52 BMP4 PAX6
10 pituitary gland development GO:0021983 9.51 BMP4 PAX6
11 camera-type eye development GO:0043010 9.5 BMP4 FBN1 PAX6
12 positive regulation of mitotic nuclear division GO:0045840 9.49 IGF1 IL1A
13 renal system development GO:0072001 9.48 AKR1B1 BMP4
14 positive regulation of ossification GO:0045778 9.4 BMP4 TAC1
15 telencephalon regionalization GO:0021978 9.37 BMP4 PAX6
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.33 AKR1B1 BMP4 IGF1
17 extracellular matrix organization GO:0030198 9.26 FBN1 NID1 TNC VCAM1
18 positive regulation of gene expression GO:0010628 9.02 BMP4 IGF1 IL1A PAX6 TNC

Molecular functions related to Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.13 FBN1 IGF1 VCAM1
2 extracellular matrix structural constituent GO:0005201 8.8 FBN1 NID1 TNC

Sources for Keratopathy

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