Aliases & Classifications for Keratopathy

MalaCards integrated aliases for Keratopathy:

Name: Keratopathy 12 15 38 72

Classifications:



External Ids:

Disease Ontology 12 DOID:2283
NCIt 50 C27012
UMLS 72 C0235270

Summaries for Keratopathy

MalaCards based summary : Keratopathy is related to bullous keratopathy and corneal disease. An important gene associated with Keratopathy is PAX6 (Paired Box 6), and among its related pathways/superpathways are Phospholipase-C Pathway and NF-KappaB Family Pathway. The drugs Tacrolimus and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and thyroid, and related phenotypes are homeostasis/metabolism and behavior/neurological

Related Diseases for Keratopathy

Diseases related to Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 371)
# Related Disease Score Top Affiliating Genes
1 bullous keratopathy 32.8 TNC TGFB2 NID1 IL1A FBN1 BMP4
2 corneal disease 30.7 TGFB2 KRT12 IL1A
3 limbal stem cell deficiency 30.7 KRT12 IL1A
4 neurotrophic keratopathy 12.3
5 climatic droplet keratopathy 12.3
6 thygeson superficial punctate keratopathy 12.2
7 corneal dystrophy, band-shaped 11.9
8 schnyder corneal dystrophy 11.6
9 palmoplantar carcinoma, multiple self-healing 11.3
10 corneal degeneration, ribbonlike, with deafness 11.2
11 keratitis, hereditary 10.7
12 corneal edema 10.6
13 cataract 10.6
14 aniridia 1 10.4
15 astigmatism 10.4
16 hydrops, lactic acidosis, and sideroblastic anemia 10.4
17 lagophthalmos 10.4
18 uveitis 10.4
19 stiff skin syndrome 10.4 TGFB2 FBN1
20 corneal ulcer 10.4
21 corneal dystrophy, fuchs endothelial, 1 10.4
22 intraocular pressure quantitative trait locus 10.3
23 myeloma, multiple 10.3
24 keratoconus 10.3
25 corneal neovascularization 10.3
26 macular retinal edema 10.3
27 ptosis 10.3
28 fuchs' endothelial dystrophy 10.3
29 corneal dystrophy 10.3
30 anterior uveitis 10.3
31 retinal detachment 10.3
32 monoclonal gammopathy of uncertain significance 10.3
33 herpes simplex 10.3
34 myopia 10.2
35 keratoconjunctivitis 10.2
36 autoimmune addison disease 10.2 NLRP1 AIRE
37 corneal degeneration 10.2
38 eye disease 10.2
39 endophthalmitis 10.2
40 corneal dystrophy, posterior polymorphous, 3 10.2 TGFB2 BMP4
41 aortic disease 10.2 TGFB2 NLRP1 FBN1
42 acanthamoeba keratitis 10.2
43 cryptosporidiosis 10.2 TAC1 IL1A
44 yemenite deaf-blind hypopigmentation syndrome 10.1
45 macular degeneration, age-related, 1 10.1
46 hypopyon 10.1
47 open-angle glaucoma 10.1
48 ectropion 10.1
49 herpes zoster 10.1
50 refractive error 10.1

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to Keratopathy

Symptoms & Phenotypes for Keratopathy

MGI Mouse Phenotypes related to Keratopathy:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 AIRE AKR1B1 BMP4 FBN1 IGF1 IL1A
2 behavior/neurological MP:0005386 10.1 AIRE AKR1B1 BMP4 FBN1 NID1 PAX6
3 cardiovascular system MP:0005385 10.08 BMP4 FBN1 IGF1 IL1A NID1 PAX6
4 nervous system MP:0003631 9.92 AIRE BMP4 FBN1 IGF1 NID1 PAX6
5 integument MP:0010771 9.88 BMP4 FBN1 IGF1 IL1A PAX6 TAC1
6 hearing/vestibular/ear MP:0005377 9.85 BMP4 IGF1 PAX6 TGFB2 TNC
7 muscle MP:0005369 9.85 BMP4 FBN1 IGF1 NID1 PAX6 TGFB2
8 normal MP:0002873 9.8 AIRE BMP4 IGF1 KRT12 PAX6 TAC1
9 renal/urinary system MP:0005367 9.7 AKR1B1 BMP4 FBN1 IGF1 PAX6 TAC1
10 respiratory system MP:0005388 9.43 AIRE BMP4 FBN1 IGF1 PAX6 TGFB2
11 vision/eye MP:0005391 9.17 AIRE AKR1B1 BMP4 KRT12 NID1 PAX6

Drugs & Therapeutics for Keratopathy

Drugs for Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
2
Acetylcholine Approved, Investigational Phase 2, Phase 3 51-84-3 187
3
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
4
Natamycin Approved Phase 2, Phase 3 7681-93-8 5281099
5
Voriconazole Approved, Investigational Phase 2, Phase 3 137234-62-9 71616
6
Adalimumab Approved Phase 2, Phase 3 331731-18-1 16219006
7
Bevacizumab Approved, Investigational Phase 3 216974-75-3
8
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
10
Fluorouracil Approved Phase 3 51-21-8 3385
11 Ophthalmic Solutions Phase 2, Phase 3
12 Pharmaceutical Solutions Phase 2, Phase 3
13 Anti-Bacterial Agents Phase 2, Phase 3
14 Anti-Infective Agents Phase 2, Phase 3
15 Neurotransmitter Agents Phase 2, Phase 3
16 abobotulinumtoxinA Phase 2, Phase 3
17 Cholinergic Agents Phase 2, Phase 3
18 Neuromuscular Agents Phase 2, Phase 3
19 Acetylcholine Release Inhibitors Phase 2, Phase 3
20 Botulinum Toxins Phase 2, Phase 3
21 Botulinum Toxins, Type A Phase 2, Phase 3
22 Antifungal Agents Phase 2, Phase 3
23 14-alpha Demethylase Inhibitors Phase 2, Phase 3
24 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
25 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
26 Steroid Synthesis Inhibitors Phase 2, Phase 3
27 Anti-Infective Agents, Local Phase 2, Phase 3
28 Antirheumatic Agents Phase 2, Phase 3
29 Antibodies Phase 2, Phase 3
30 Antibodies, Monoclonal Phase 2, Phase 3
31 Immunoglobulins Phase 2, Phase 3
32 Angiogenesis Inhibitors Phase 3
33 Angiogenesis Modulating Agents Phase 3
34 Antineoplastic Agents, Immunological Phase 3
35 Peripheral Nervous System Agents Phase 3
36 Immunologic Factors Phase 3
37 Immunosuppressive Agents Phase 3
38 Anti-Inflammatory Agents Phase 3
39 Gastrointestinal Agents Phase 3
40 Antiemetics Phase 3
41 glucocorticoids Phase 3
42
protease inhibitors Phase 3
43 HIV Protease Inhibitors Phase 3
44 Hormones Phase 3
45 Antineoplastic Agents, Hormonal Phase 3
46 Hormone Antagonists Phase 3
47 BB 1101 Phase 3
48 Antimetabolites, Antineoplastic Phase 3
49 Autonomic Agents Phase 3
50 Antimetabolites Phase 3

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 Topical Tacrolimus in Vernal Keratoconjunctivitis Unknown status NCT02456025 Phase 4 Topical tacrolimus
2 A Single-site, Open-Label Prospective Evaluation of Biocompatibility and Corneal Staining Associated With Use of Bausch & Lomb (B+L) BioTrue Contact Lens Multi-purpose Solution (MPS) and B+L PureVision Contact Lenses. Completed NCT01268306 Phase 4
3 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
4 Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis: a Prospective Randomized Double Masked Clinical Trial Unknown status NCT03230058 Phase 2, Phase 3 Group 1 Natamycin 5% Suspension + voriconazole 1% eye drops; Group 2 Natamycin 5% Suspension + Vehicle eye drops
5 The Silicone Study Completed NCT00000140 Phase 3 Perfluoropropane;Sulfur Hexafluoride;Silicone Oil
6 Evaluation of the Efficacy of Adalimumab for the Treatment of Uveitis in Juvenile Idiopathic Arthritis: Randomized Double-blind Placebo-controlled Trial Completed NCT01385826 Phase 2, Phase 3 Anti-tumor necrosis factor alpha monoclonal antibody;placebo
7 Phase 3, Multi-Center, Randomized, Double Masked, Placebo Controlled Clinical Study to Assess the Safety and Efficacy of RGN-259 Ophthalmic Solution for the Treatment of Neurotrophic Keratopathy: SEER-1 Recruiting NCT02600429 Phase 3 RGN-259;Placebo
8 The Use of Bevacizumab as a Modulator of Wound Healing Following Trabeculectomy Surgery: A Single Centre Randomised Controlled Phase III Pilot Study Active, not recruiting NCT02767219 Phase 3 bevacizumab;5-fluorouracil;Dexamethasone
9 Phase IIa Clinical Trial to Study the Feasability and Security of the Expanded Autologous Stem Cells (ASC) From Lipoaspirate in the Bilateral Limbic Associated Keratopathy Treatment Unknown status NCT01808378 Phase 2 Expanded adipose-derived stem cells
10 Comparative Analysis of Human Amniotic Membrane Graft Versus Contact Lenses in Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
11 Evaluation of the Pain and Visual Outcome Associated With Location of Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
12 Evaluation the Effect of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal Epithelium Healing (Phase I and II Clinical Trial) Completed NCT02746848 Phase 1, Phase 2
13 An Open Label, Pilot (Phase I/II), Dose-Escalation Safety and Tolerability Study of Combretastatin A4 Phosphate in Patients With Neovascular Age-Related Macular Degeneration. Completed NCT01570790 Phase 1, Phase 2 Combretastatin A-4 phosphate;Combretastatin A-4 Phosphate;Combretastatin A-4 Phosphate
14 Effects of Oral Mucolytics on Tear Film and Ocular Surface Completed NCT01713179 Phase 1, Phase 2 Ambroxol hydrochloride (Mucopect®, 60 mg, Boehringer Ingelheim)
15 Long-Term Clinical Trial of Nitisinone in Alkaptonuria Completed NCT00107783 Phase 2 Nitisinone (NTBC)
16 A Multicenter, Randomized, Open-label, Two-arms Phase I/II Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Recruiting NCT03084861 Phase 1, Phase 2 Cord Blood Eye Drops;Conventional treatment
17 A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) Patients Terminated NCT01972438 Phase 2 ASEDs;Saline
18 A First-in-human Phase 1 Dose Escalation Study of SAR428926 in Patients With Advanced Solid Tumors Completed NCT02575781 Phase 1 SAR428926
19 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection Completed NCT02068430 Phase 1 Riboflavin 0.1%
20 Blood Based Eyedrops From Different Sources in the Treatment of Severe Keratopathy - A Randomized Clinical Trial Unknown status NCT03064984
21 Comparison of Aqueous and Plasma Glucose Level in Diabetic Patients Unknown status NCT02750098
22 Corneal Transplantation Guided by OCT RESCAN: Pre-op, Intra-op and Post-op Evaluation Unknown status NCT02736877
23 Prospective, Randomized Crossover Study Of The Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 saline solution
24 Study of the Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking Completed NCT01106274
25 Amniotic Membrane and Anterior Stromal Puncture: a Comparative Study in the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308
26 Eyelash Line Resection for Entropion Associated With Down's Syndrome Completed NCT01758718
27 Amniotic Membrane Transplant in Symptomatic Bullous Keratopathy Patients: Confocal Microscopy & AS-OCT Long Term Results Completed NCT03450954
28 Study of Automated Lamellar Keratectomy With a New Option in Treatment in Symptomatic Patients With Bullous Keratopathy. Completed NCT00654888 Mitomycin
29 The Influences of Dry Eye Disease on Optical Quality Completed NCT04043949
30 The Application of Subconjunctival Injection of Bevacizumab (Avastin) in the Treatment of Corneal Neovasculization Completed NCT00681603 subconjunctival injection of bevacizumab ( 1.25 to 2.50 mg)
31 Randomised Trial Comparing the Efficacy of Ocular Lubricant (Lacrilube) and Polyacrylamide Hydrogel Dressing (Geliperm) for the Prevention of Exposure Keratopathy in the Critically Ill Completed NCT00513734
32 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
33 Measurement of the Retinal Oxygen Saturaiton After Long-term Silicon Oil Tamponade With Oxymap Completed NCT02423382
34 Long-term Results of Topical Cyclosporine 0.05% in the Treatment of Atopic Keratoconjunctivitis Completed NCT00987467 Cyclosporin 0.05% ophthalmic
35 Prospective, Randomized Crossover Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Completed NCT02660151 Salt solution
36 Establishment of Biomarkers for Fabry Disease Completed NCT01165697
37 Emulsification of Different Viscosity Silicone Oil After Complicated Retinal Detachment Surgery: A Randomized Double-masked Clinical Trial Completed NCT02988583
38 Phenotype-Genotype Correlation in Aniridia Completed NCT00265590
39 Clinical Comparison of Two Anesthetic Preparations for Intravitreal Injection Completed NCT01087489 4% lidocaine;3.5% ophthalmic lidocaine gel
40 To Investigate the Precision and Agreement of SS-1000 and the Predicate Device Pentacam in a Repeatability and Reproducibility Trial (PASP) Completed NCT02077790
41 Zhongshan Ophthalmic Center, Sun Yat-Sen University,China Recruiting NCT03447041
42 Prospective, Randomized Multi-Center Study of Using the Hyper-CL™ Lens in Subjects Suffering From Bacterial Keratitis Recruiting NCT03845374
43 Biomarker for Cystinosis Disease AN INTERNATIONAL, MULTICENTER, EPIDEMIOLOGICAL PROTOCOL Recruiting NCT02837523
44 An Open-label, Pilot Study to Assess the Safety, Tolerability and Preliminary Efficacy of EDTA Eye Drops on Band Keratopathy Not yet recruiting NCT03985371 Early Phase 1 EDTA Eye Drops

Search NIH Clinical Center for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

Anatomical Context for Keratopathy

MalaCards organs/tissues related to Keratopathy:

41
Endothelial, Eye, Thyroid, Skin, Breast, T Cells, Brain

Publications for Keratopathy

Articles related to Keratopathy:

(show top 50) (show all 3794)
# Title Authors PMID Year
1
Comparative analysis of biomechanical parameters of the corneas following Descemet membrane endothelial keratoplasty and contralateral healthy corneas. 38
31187244 2019
2
Five-Year Outcomes of Ultrathin Descemet Stripping Automated Endothelial Keratoplasty. 38
31246680 2019
3
Intraoperative Photoactivated Chromophore for Infectious Keratitis-Corneal Cross-Linking (PACK-CXL) During Penetrating Keratoplasty for the Management of Fungal Keratitis in an Immunocompromised Patient. 38
31278588 2019
4
In vivo confocal microscopy of verticillata-like paraproteinemic keratopathy in a patient with monoclonal gammopathy of uncertain significance evolving into smoldering multiple myeloma. 38
31317086 2019
5
Prevalence and Risk Factors of Exposure Keratopathy Across Different Intensive Care Units. 38
31394552 2019
6
Anterior Chamber Rebubbling With Perfluoropropane (C3F8) After Failed Rebubbling Attempts for Persistent Descemet Membrane Endothelial Keratoplasty Graft Detachments. 38
31107285 2019
7
Microkeratome-assisted ultrathin Descemet's stripping automated endothelial keratoplasty: A randomized trial comparing single-pass versus double-pass technique. 38
31332110 2019
8
NS Endo-Inserter: A New Graft Inserter for Descemet Stripping Automated Endothelial Keratoplasty. 38
31403531 2019
9
Central retinal artery occlusion after Descemet membrane reposition by intracameral air: A case report. 38
31432690 2019
10
Comparative ophthalmic assessment of patients receiving tafenoquine or chloroquine/primaquine in a randomized clinical trial for Plasmodium vivax malaria radical cure. 38
30269312 2019
11
Cenegermin in Pediatric Neurotrophic Keratopathy. 38
31403527 2019
12
[Neurotrophic keratopathy : Principles, diagnostics and treatment]. 38
31372724 2019
13
Lacrimal tissue resection in Fasanella Servat operation and the correlation to dry eye. 38
31393212 2019
14
Lateral Antebrachial Cutaneous Nerve as Autologous Graft for Mini-Invasive Corneal Neurotization (MICORNE). 38
31246678 2019
15
Glaucoma Drainage Devices and Reasons for Keratoplasty. 38
31393312 2019
16
Colonization of therapeutic contact lens by dematiaceous fungi. 38
30981660 2019
17
Indications and techniques of corneal transplantation in a referral center in Colombia, South America (2012-2016). 38
30047076 2019
18
Review of laser vision correction (LASIK, PRK and SMILE) with simultaneous accelerated corneal crosslinking - long-term results. 38
31411927 2019
19
Referral for Ophthalmology Evaluation and Visual Sequelae in Children With Primary Brain Tumors. 38
31373649 2019
20
Cogan-Reese syndrome with Iris cyst: A novel presentation. 38
31104851 2019
21
Surgical treatment of severe congenital ptosis using deep temporal fascia. 38
30325240 2019
22
Does Preoperative or Postoperative Graft Thickness Influence Postoperative Visual Acuity in Descemet Stripping Automated Endothelial Keratoplasty for Advanced Pseudophakic Bullous Keratopathy? 38
31436644 2019
23
Factors associated with keratopathy in captive pinnipeds. 38
31260400 2019
24
Use of Tachosil® as an adjuvant therapeutic option in neurotrophic keratopathy in order to prevent perforation. 38
31238463 2019
25
Methotrexate as an Adjuvant in Severe Thyroid Eye Disease: Does It Really Work as a Steroid-Sparing Agent? 38
30624412 2019
26
Persistence of Descemet membrane and recipient-type endothelium after keratoplasty. A case report. 38
30890280 2019
27
Graft Survival After Penetrating and Endothelial Keratoplasty in Iridocorneal Endothelial Syndrome. 38
31335531 2019
28
Procurement, storage and utilization trends of eye banks in India. 38
31238409 2019
29
Comparative study of penetrating keratoplasty and vitreoretinal surgery with Eckardt temporary keratoprosthesis in ocular trauma versus non-trauma patients. 38
31363832 2019
30
Clinical outcomes and time to recurrence of phototherapeutic keratectomy in Japan. 38
31277131 2019
31
Multimodal Imaging Report of Crystalline Keratopathy in Relapsing Polychondritis. 38
30969261 2019
32
Ectodermal Dysplasia: Association with Anti-Basement Membrane Autoantibodies. 38
31268817 2019
33
Ocular abnormalities in a herd of Old Kladruber Horses: A cross-sectional study. 38
30288880 2019
34
Improved Outcomes in Patients with Retinal Detachment after Implementation of a Silicone Oil Registry and Phone Call Reminder System. 38
31277794 2019
35
Changing Indications for Corneal Transplantations in Southern Taiwan From 2008 to 2018. 38
31313699 2019
36
Effect of Unilateral Endothelial Keratoplasty on Vision-Related Quality-of-Life Outcomes in the Descemet Endothelial Thickness Comparison Trial (DETECT): A Secondary Analysis of a Randomized Clinical Trial. 38
31046075 2019
37
Management of Nocardia Interface Keratitis After Descemet Membrane Endothelial Keratoplasty. 38
31306288 2019
38
Association of toll-like receptor 10 polymorphisms with paediatric idiopathic uveitis in Han Chinese. 38
31272954 2019
39
An update on the modern management of paediatric uveitis. 38
31272956 2019
40
Ophthalmic Changes Following Maxillectomy With or Without Postoperative Radiation Therapy. 38
31299741 2019
41
Corneal Higher-Order Aberrations in Descemet Membrane Endothelial Keratoplasty versus Ultrathin DSAEK in the Descemet Endothelial Thickness Comparison Trial: A Randomized Clinical Trial. 38
30776384 2019
42
Corneal neurotization. 38
31033738 2019
43
Evaluation of complications and visual outcome in various nucleus delivery techniques of manual small incision cataract surgery. 38
31238414 2019
44
Central Toxic Keratopathy After Contact Lens Wear and Mechanical Debridement: Clinical Characteristics, and Visual and Corneal Tomographic Outcomes. 38
31241605 2019
45
Medial canthoplasty for the management of exposure keratopathy. 38
30710111 2019
46
The impact of hyperglycemia on the corneal epithelium: Molecular mechanisms and insight. 38
31238114 2019
47
Keratoprostheses in silicone oil-filled eyes: long-term outcomes. 38
30021817 2019
48
Patterns of uveitis in children according to age: comparison of visual outcomes and complications in a tertiary center. 38
31248388 2019
49
The role of autophagy in the pathogenesis of exposure keratitis. 38
30973208 2019
50
Corneal vortex keratopathy in childhood-onset systemic lupus erythematosus (c-SLE). 38
31190285 2019

Variations for Keratopathy

Expression for Keratopathy

Search GEO for disease gene expression data for Keratopathy.

Pathways for Keratopathy

Pathways related to Keratopathy according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.72 TNC TGFB2 IGF1 FBN1 BMP4
2
Show member pathways
12.42 TGFB2 IL1A IGF1 BMP4
3
Show member pathways
12.11 TGFB2 PAX6 IGF1 BMP4
4
Show member pathways
12.01 TNC TGFB2 NID1 FBN1 BMP4
5
Show member pathways
11.88 TGFB2 IL1A IGF1 BMP4
6 11.8 PAX6 IGF1 BMP4
7 11.76 PAX6 IGF1 BMP4
8
Show member pathways
11.72 TGFB2 IL1A IGF1 BMP4
9 11.4 PAX6 IGF1 BMP4
10
Show member pathways
11.3 TGFB2 FBN1 BMP4
11 11.06 PAX6 IGF1 BMP4
12 10 TNC TGFB2 IL1A IGF1 FBN1 BMP4

GO Terms for Keratopathy

Cellular components related to Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 TNC TGFB2 TAC1 NID1 IL1A IGF1
2 collagen-containing extracellular matrix GO:0062023 9.46 TNC TGFB2 NID1 FBN1
3 basement membrane GO:0005604 9.43 TNC NID1 FBN1
4 extracellular space GO:0005615 9.23 TNC TGFB2 TAC1 IL1A IGF1 FBN1

Biological processes related to Keratopathy according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.92 TNC TGFB2 IGF1 BMP4
2 negative regulation of cell proliferation GO:0008285 9.87 TGFB2 PAX6 IL1A BMP4
3 extracellular matrix organization GO:0030198 9.81 TNC NID1 FBN1
4 kidney development GO:0001822 9.73 TGFB2 FBN1 BMP4
5 cellular protein metabolic process GO:0044267 9.67 TNC IGF1 FBN1 BMP4
6 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.65 IGF1 BMP4
7 response to wounding GO:0009611 9.65 TNC TGFB2 PAX6
8 positive regulation of gene expression GO:0010628 9.65 TNC PAX6 IL1A IGF1 BMP4
9 positive regulation of epithelial cell migration GO:0010634 9.64 TGFB2 TAC1
10 metanephros development GO:0001656 9.63 FBN1 BMP4
11 eye development GO:0001654 9.63 TGFB2 PAX6
12 odontogenesis GO:0042476 9.62 TGFB2 BMP4
13 pituitary gland development GO:0021983 9.61 PAX6 BMP4
14 neuron fate commitment GO:0048663 9.61 PAX6 BMP4
15 camera-type eye development GO:0043010 9.61 PAX6 FBN1 BMP4
16 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.6 TGFB2 BMP4
17 outflow tract septum morphogenesis GO:0003148 9.59 TGFB2 BMP4
18 positive regulation of mitotic nuclear division GO:0045840 9.58 IL1A IGF1
19 negative regulation of epithelial cell proliferation GO:0050680 9.58 TGFB2 PAX6 BMP4
20 pulmonary valve morphogenesis GO:0003184 9.55 TGFB2 BMP4
21 cardiac right ventricle morphogenesis GO:0003215 9.54 TGFB2 BMP4
22 salivary gland morphogenesis GO:0007435 9.52 TGFB2 PAX6
23 membranous septum morphogenesis GO:0003149 9.51 TGFB2 BMP4
24 positive regulation of smooth muscle cell proliferation GO:0048661 9.5 IGF1 BMP4 AKR1B1
25 pharyngeal arch artery morphogenesis GO:0061626 9.49 TGFB2 BMP4
26 telencephalon regionalization GO:0021978 9.46 PAX6 BMP4
27 positive regulation of protein secretion GO:0050714 9.33 TGFB2 IL1A IGF1
28 renal system development GO:0072001 9.27 BMP4
29 skeletal system development GO:0001501 9.26 TGFB2 IGF1 FBN1 BMP4
30 positive regulation of ossification GO:0045778 8.8 TGFB2 TAC1 BMP4
31 positive regulation of transcription by RNA polymerase II GO:0045944 10.04 PAX6 IL1A IGF1 BMP4 AIRE

Molecular functions related to Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 TGFB2 IL1A BMP4
2 growth factor activity GO:0008083 9.13 TGFB2 IGF1 BMP4
3 extracellular matrix structural constituent GO:0005201 8.8 TNC NID1 FBN1

Sources for Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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