MCID: KRT008
MIFTS: 47

Keratopathy

Categories: Neuronal diseases

Aliases & Classifications for Keratopathy

MalaCards integrated aliases for Keratopathy:

Name: Keratopathy 12 15 37 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2283
NCIt 49 C27012
UMLS 71 C0235270

Summaries for Keratopathy

MalaCards based summary : Keratopathy is related to neurotrophic keratopathy and bullous keratopathy. An important gene associated with Keratopathy is PAX6 (Paired Box 6), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Tacrolimus and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and thyroid, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Keratopathy

Diseases related to Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 533)
# Related Disease Score Top Affiliating Genes
1 neurotrophic keratopathy 34.3 TACR1 TAC1
2 bullous keratopathy 33.3 TGFB3 TGFB2 NID1 ITGB1 IL1A IGF1
3 punctate epithelial keratoconjunctivitis 32.9 TAC1 OGFR LACRT
4 limbal stem cell deficiency 31.0 KRT12 IL1A ICAM1
5 keratitis, hereditary 30.9 TNF PAX6 CYP1B1
6 corneal ulcer 30.8 LACRT IL1A CYP1B1
7 aniridia 1 30.7 PAX6 KRT12 CYP1B1
8 keratoconus 30.7 TNF TGFB2 KRT12 IL1A
9 endophthalmitis 30.6 TNF ICAM1 CXCL8
10 macular retinal edema 30.5 TNF ICAM1 CXCL8 AKR1B1
11 blepharitis 30.5 TNF LACRT IL4
12 retinal detachment 30.4 TNF TGFB2 PAX6 IGF1 CXCL8
13 keratoconjunctivitis sicca 30.4 TNF LACRT IL4 IL1A
14 intraocular pressure quantitative trait locus 30.2 TGFB2 PAX6 GAPDH CYP1B1
15 apnea, obstructive sleep 30.2 TNF IGF1 CXCL8
16 posterior uveitis 30.1 TNF IL4 IL1A
17 microvascular complications of diabetes 5 30.1 TGFB2 IGF1 ICAM1 AKR1B1
18 uveitis 30.1 TNF TGFB2 IL4 IL1A ICAM1 CXCL8
19 leprosy 3 30.1 TNF IL4 CXCL8
20 lepromatous leprosy 30.1 TNF IL4 ICAM1
21 keratoconjunctivitis 30.0 TNF IL4 ICAM1 CXCL8 AIRE
22 corneal disease 30.0 TNF TGFB2 TAC1 PAX6 LACRT KRT12
23 haemophilus influenzae 30.0 TNF CXCL8
24 conjunctivitis 29.9 TNF IL4 ICAM1 CXCL8
25 fibromyalgia 29.8 TNF TACR1 IGF1 CXCL8
26 candidiasis 29.8 TNF IL4 CXCL8 AIRE
27 endocarditis 29.8 TNF IL1A GAPDH CXCL8
28 hypersensitivity reaction type iv disease 29.7 TNF IL4 CXCL8
29 poliomyelitis 29.7 TNF IL4 ICAM1
30 autoimmune disease 29.7 TNF IL4 IL1A CXCL8 AIRE
31 cataract 29.7 TNF TGFB3 TGFB2 PAX6 IGF1 ICAM1
32 erythema multiforme 29.7 TNF IL4 ICAM1 CXCL8
33 dermatitis 29.7 TNF IL4 IL1A CXCL8
34 neuritis 29.7 TNF IL4 CXCL8
35 sleep apnea 29.6 TNF TAC1 IGF1 ICAM1 CXCL8
36 myeloma, multiple 29.6 TNF IL4 IGF1 ICAM1 GAPDH CXCL8
37 graves' disease 29.6 IL4 IL1A ICAM1 AIRE
38 herpes simplex virus keratitis 29.5 ICAM1 CXCL8
39 allergic conjunctivitis 29.5 TNF IL4 ICAM1 CXCL8
40 rhinitis 29.4 TNF IL4 ICAM1 CXCL8
41 macular degeneration, age-related, 1 29.3 TNF TGFB2 PAX6 IGF1 ICAM1 GAPDH
42 leptospirosis 29.3 TNF IL4 IL1A ICAM1 CXCL8
43 meningitis 29.3 TNF IL4 IL1A ICAM1 CXCL8
44 skin disease 29.3 TNF TAC1 IL4 IL1A ICAM1 CXCL8
45 allergic hypersensitivity disease 28.9 TNF TACR1 TAC1 IL4 ICAM1 CXCL8
46 peripheral nervous system disease 28.8 TNF TAC1 IL4 IGF1 GAPDH CXCL8
47 dermatitis, atopic 28.7 TNF TACR1 TAC1 IL4 IL1A ICAM1
48 rheumatoid arthritis 28.6 TNF TGFB3 TGFB2 IL4 IL1A ICAM1
49 psoriasis 28.3 TNF TACR1 ITGB1 IL4 IL1A ICAM1
50 diabetes mellitus 28.2 TNF IL4 IL1A IGF1 ICAM1 GAPDH

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to Keratopathy

Symptoms & Phenotypes for Keratopathy

MGI Mouse Phenotypes related to Keratopathy:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 AIRE AKR1B1 CYP1B1 GAPDH ICAM1 IGF1
2 cardiovascular system MP:0005385 10.27 GAPDH ICAM1 IGF1 IL1A ITGB1 NID1
3 hematopoietic system MP:0005397 10.2 AIRE GAPDH ICAM1 IGF1 IL1A IL4
4 immune system MP:0005387 10.14 AIRE ICAM1 IGF1 IL1A IL4 ITGB1
5 digestive/alimentary MP:0005381 10.08 AIRE ICAM1 IL4 ITGB1 PAX6 TGFB2
6 integument MP:0010771 10.02 ICAM1 IGF1 IL1A IL4 ITGB1 PAX6
7 nervous system MP:0003631 10 AIRE ICAM1 IGF1 IL4 ITGB1 NID1
8 neoplasm MP:0002006 9.92 AIRE CYP1B1 ICAM1 IGF1 IL1A ITGB1
9 renal/urinary system MP:0005367 9.76 AKR1B1 GAPDH IGF1 IL4 ITGB1 PAX6
10 respiratory system MP:0005388 9.61 AIRE IGF1 IL4 ITGB1 PAX6 TACR1
11 vision/eye MP:0005391 9.4 AIRE AKR1B1 CYP1B1 ICAM1 IL4 ITGB1

Drugs & Therapeutics for Keratopathy

Drugs for Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
2 Pharmaceutical Solutions Phase 4
3
Bevacizumab Approved, Investigational Phase 3 216974-75-3
4
Acetylcholine Approved, Investigational Phase 2, Phase 3 51-84-3 187
5
Clotrimazole Approved, Vet_approved Phase 2, Phase 3 23593-75-1 2812
6
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
7
Fluorouracil Approved Phase 3 51-21-8 3385
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
9
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
10
Voriconazole Approved Phase 2, Phase 3 137234-62-9 71616
11
Natamycin Approved Phase 2, Phase 3 7681-93-8 5281099
12
Adalimumab Approved Phase 2, Phase 3 331731-18-1 16219006
13
Mycophenolic acid Approved Phase 2, Phase 3 24280-93-1 446541
14 Ophthalmic Solutions Phase 2, Phase 3
15 Angiogenesis Inhibitors Phase 3
16 Antineoplastic Agents, Immunological Phase 3
17 abobotulinumtoxinA Phase 2, Phase 3
18 Cholinergic Agents Phase 2, Phase 3
19 Botulinum Toxins Phase 2, Phase 3
20 Botulinum Toxins, Type A Phase 2, Phase 3
21 Immunosuppressive Agents Phase 3
22 Antifungal Agents Phase 2, Phase 3
23 Hormones Phase 3
24 Antineoplastic Agents, Hormonal Phase 3
25 Hormone Antagonists Phase 3
26 Antiemetics Phase 3
27 glucocorticoids Phase 3
28 Antimetabolites Phase 3
29 Anti-Inflammatory Agents Phase 3
30 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
31 Anti-Infective Agents, Local Phase 2, Phase 3
32 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
33 Immunologic Factors Phase 2, Phase 3
34 Antibodies Phase 2, Phase 3
35 Antibodies, Monoclonal Phase 2, Phase 3
36 Immunoglobulins Phase 2, Phase 3
37 Anti-Bacterial Agents Phase 2, Phase 3
38 Antibiotics, Antitubercular Phase 2, Phase 3
39 Anti-Infective Agents Phase 2, Phase 3
40 Antitubercular Agents Phase 2, Phase 3
41
Nitisinone Approved, Investigational Phase 2 104206-65-7 115355
42
Ambroxol Approved, Investigational Phase 1, Phase 2 18683-91-5
43
Tyrosine Approved, Investigational, Nutraceutical Phase 2 60-18-4 6057
44 Combretastatin Investigational Phase 1, Phase 2 82855-09-2
45
Fosbretabulin Investigational Phase 1, Phase 2 222030-63-9 5351387
46 Mitogens Phase 2
47 Anesthetics Phase 2
48 Endothelial Growth Factors Phase 2
49 Tubulin Modulators Phase 1, Phase 2
50 Antimitotic Agents Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 57)
# Name Status NCT ID Phase Drugs
1 Topical Tacrolimus in Vernal Keratoconjunctivitis Unknown status NCT02456025 Phase 4 Topical tacrolimus
2 A Single-site, Open-Label Prospective Evaluation of Biocompatibility and Corneal Staining Associated With Use of Bausch & Lomb (B+L) BioTrue Contact Lens Multi-purpose Solution (MPS) and B+L PureVision Contact Lenses. Completed NCT01268306 Phase 4
3 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
4 The Use of Bevacizumab as a Modulator of Wound Healing Following Trabeculectomy Surgery: A Single Centre Randomised Controlled Phase III Pilot Study Unknown status NCT02767219 Phase 3 bevacizumab;5-fluorouracil;Dexamethasone
5 Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis: a Prospective Randomized Double Masked Clinical Trial Unknown status NCT03230058 Phase 2, Phase 3 Group 1 Natamycin 5% Suspension + voriconazole 1% eye drops; Group 2 Natamycin 5% Suspension + Vehicle eye drops
6 The Silicone Study Completed NCT00000140 Phase 3 Perfluoropropane;Sulfur Hexafluoride;Silicone Oil
7 Evaluation of the Efficacy of Adalimumab for the Treatment of Uveitis in Juvenile Idiopathic Arthritis: Randomized Double-blind Placebo-controlled Trial Completed NCT01385826 Phase 2, Phase 3 Anti-tumor necrosis factor alpha monoclonal antibody;placebo
8 Phase 3, Multi-Center, Randomized, Double Masked, Placebo Controlled Clinical Study to Assess the Safety and Efficacy of RGN-259 Ophthalmic Solution for the Treatment of Neurotrophic Keratopathy: SEER-1 Recruiting NCT02600429 Phase 3 RGN-259;Placebo
9 Topical 0.03% Tacrolimus Versus Systemic Mycophenolate Mofetil for Preventing Graft Rejection After Repeat Keratoplasty: One-year Results of a Randomized Clinical Trial Recruiting NCT04147390 Phase 2, Phase 3 prescribe topical 0.03 % tacrolimus;prescribe mycophenolate mofetil(MMF)
10 Phase IIa Clinical Trial to Study the Feasability and Security of the Expanded Autologous Stem Cells (ASC) From Lipoaspirate in the Bilateral Limbic Associated Keratopathy Treatment Unknown status NCT01808378 Phase 2 Expanded adipose-derived stem cells
11 Comparative Analysis of Human Amniotic Membrane Graft Versus Contact Lenses in Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
12 Evaluation of the Pain and Visual Outcome Associated With Location of Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
13 Evaluation the Effect of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal Epithelium Healing (Phase I and II Clinical Trial) Completed NCT02746848 Phase 1, Phase 2
14 An Open Label, Pilot (Phase I/II), Dose-Escalation Safety and Tolerability Study of Combretastatin A4 Phosphate in Patients With Neovascular Age-Related Macular Degeneration. Completed NCT01570790 Phase 1, Phase 2 Combretastatin A-4 phosphate;Combretastatin A-4 Phosphate;Combretastatin A-4 Phosphate
15 Long-Term Clinical Trial of Nitisinone in Alkaptonuria Completed NCT00107783 Phase 2 Nitisinone (NTBC)
16 Effects of Oral Mucolytics on Tear Film and Ocular Surface Completed NCT01713179 Phase 1, Phase 2 Ambroxol hydrochloride (Mucopect®, 60 mg, Boehringer Ingelheim)
17 A Multicenter, Randomized, Open-label, Two-arms Phase I/II Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Recruiting NCT03084861 Phase 1, Phase 2 Cord Blood Eye Drops;Conventional treatment
18 Safety and Feasibility of Cultivated Autologous Limbal Epithelial Cell Transplantation in the Treatment of Limbal Stem Cell Deficiency (LSCD) Recruiting NCT02592330 Phase 1, Phase 2
19 A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) Patients Terminated NCT01972438 Phase 2 ASEDs;Saline
20 A First-in-human Phase 1 Dose Escalation Study of SAR428926 in Patients With Advanced Solid Tumors Completed NCT02575781 Phase 1 SAR428926
21 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection Completed NCT02068430 Phase 1 Riboflavin 0.1%
22 Phase 1 Clinical Study to Evaluate Safety and Tolerability of Magnetic Human Corneal Endothelial Cells in the Treatment of Corneal Edema Recruiting NCT04191629 Phase 1
23 Zhongshan Ophthalmic Center, Sun Yat-Sen University,China Unknown status NCT03447041
24 Blood Based Eyedrops From Different Sources in the Treatment of Severe Keratopathy - A Randomized Clinical Trial Unknown status NCT03064984
25 Comparison of Aqueous and Plasma Glucose Level in Diabetic Patients Unknown status NCT02750098
26 Corneal Transplantation Guided by OCT RESCAN: Pre-op, Intra-op and Post-op Evaluation Unknown status NCT02736877
27 Prospective, Randomized Crossover Study Of The Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 saline solution
28 Study of the Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking Completed NCT01106274
29 Amniotic Membrane and Anterior Stromal Puncture: a Comparative Study in the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308
30 Amniotic Membrane Transplant in Symptomatic Bullous Keratopathy Patients: Confocal Microscopy & AS-OCT Long Term Results Completed NCT03450954
31 Eyelash Line Resection for Entropion Associated With Down's Syndrome Completed NCT01758718
32 Study of Automated Lamellar Keratectomy With a New Option in Treatment in Symptomatic Patients With Bullous Keratopathy. Completed NCT00654888 Mitomycin
33 The Influences of Dry Eye Disease on Optical Quality Completed NCT04043949
34 In Vivo Evaluation of Corneal Nerves and Epithelial Healing After Treatment With Nerve Growth Factor for Neurotrophic Keratopathy Completed NCT04293549 Cenegermin, recombinant human Nerve Growth Factor (rhNGF) eyedrops
35 Randomised Trial Comparing the Efficacy of Ocular Lubricant (Lacrilube) and Polyacrylamide Hydrogel Dressing (Geliperm) for the Prevention of Exposure Keratopathy in the Critically Ill Completed NCT00513734
36 The Application of Subconjunctival Injection of Bevacizumab (Avastin) in the Treatment of Corneal Neovasculization Completed NCT00681603 subconjunctival injection of bevacizumab ( 1.25 to 2.50 mg)
37 Comparative Long-term Results After DSAEK, UT-DSAEK and DMEK for Fuchs Endothelial Corneal Dystophy and Moderated Pseudophakic Bullous Keratopathy Completed NCT04424550
38 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
39 Measurement of the Retinal Oxygen Saturaiton After Long-term Silicon Oil Tamponade With Oxymap Completed NCT02423382
40 Long-term Results of Topical Cyclosporine 0.05% in the Treatment of Atopic Keratoconjunctivitis Completed NCT00987467 Cyclosporin 0.05% ophthalmic
41 Prospective, Randomized Crossover Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Completed NCT02660151 Salt solution
42 Clinical Comparison of Two Anesthetic Preparations for Intravitreal Injection Completed NCT01087489 4% lidocaine;3.5% ophthalmic lidocaine gel
43 Establishment of Biomarkers for Fabry Disease Completed NCT01165697
44 Phenotype-Genotype Correlation in Aniridia Completed NCT00265590
45 Emulsification of Different Viscosity Silicone Oil After Complicated Retinal Detachment Surgery: A Randomized Double-masked Clinical Trial Completed NCT02988583
46 To Investigate the Precision and Agreement of SS-1000 and the Predicate Device Pentacam in a Repeatability and Reproducibility Trial (PASP) Completed NCT02077790
47 Prospective, Randomized Multi-Center Study of Using the Hyper-CL™ Lens in Subjects Suffering From Bacterial Keratitis Recruiting NCT03845374
48 The Postoperative Head Position as a Predictor of the Surgical Outcome After DMEK Recruiting NCT04387331
49 Keratoconus, Corneal Diseases and Transplant Registry (KCDTR) Recruiting NCT04164407
50 The Marker Expression of Corneal Surface From Penetrating Keratopathy After Collagenase A Assisted COMET Case Series Recruiting NCT04066439

Search NIH Clinical Center for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

Anatomical Context for Keratopathy

MalaCards organs/tissues related to Keratopathy:

40
Endothelial, Eye, Thyroid, Skin, Breast, T Cells, Testes

Publications for Keratopathy

Articles related to Keratopathy:

(show top 50) (show all 3972)
# Title Authors PMID Year
1
Diabetic keratopathy: Insights and challenges. 61
32092364 2020
2
Sterile Corneal Perforation Occurring Several Years After Biliopancreatic Diversion. 61
32144634 2020
3
The 3-year outcomes of corneal tattooing for severely disfigured corneas. 61
32297049 2020
4
Role of VIP and Sonic Hedgehog Signaling Pathways in Mediating Epithelial Wound Healing, Sensory Nerve Regeneration, and Their Defects in Diabetic Corneas. 61
32345752 2020
5
Leucine-rich α-2-glycoprotein-1 promotes diabetic corneal epithelial wound healing and nerve regeneration via regulation of matrix metalloproteinases. 61
32387619 2020
6
Silicone Oil-Associated Extensive Intraocular Ossification: A case report. 61
32498551 2020
7
Spontaneous late reopening of a successfully operated and closed full-thickness macular hole. 61
32195442 2020
8
Corneal Blindness in Asia: A Systematic Review and Meta-Analysis to Identify Challenges and Opportunities. 61
32501834 2020
9
First-in-Human, Multicenter, Phase I Dose-Escalation and Expansion Study of Anti-Mesothelin Antibody-Drug Conjugate Anetumab Ravtansine in Advanced or Metastatic Solid Tumors. 61
32213105 2020
10
Resolution of Corneal Fibrosis After Descemet's Stripping Automated Endothelial Keratoplasty: A Case Report. 61
32144575 2020
11
Descemet's membrane development, structure, function and regeneration. 61
32522478 2020
12
Comment on: Management of Congenital Aniridia-Associated Keratopathy: Long-term Outcomes From a Tertiary Referral Center. 61
32307036 2020
13
Reply to Comment on: Management of Congenital Aniridia-Associated Keratopathy: Long-term Outcomes From a Tertiary Referral Center. 61
32312475 2020
14
Rapidly progressive streptococcus dysgalactiae corneal ulceration associated with erlotinib use in stage IV lung cancer. 61
32140616 2020
15
In Vivo Effect of RSH-12, a Novel Selective MMP-9 Inhibitor Peptide, in the Treatment of Experimentally Induced Dry Eye Model. 61
32567381 2020
16
Microvesicle delivery of a lysosomal transport protein to ex vivo rabbit cornea. 61
32280591 2020
17
Overall clinical outcomes of Descemet membrane endothelial keratoplasty in 600 consecutive eyes: A large retrospective case series. 61
32461427 2020
18
Real-time intraoperative ultrasound biomicroscopy for determining graft orientation during Descemet's membrane endothelial keratoplasty. 61
32578923 2020
19
Short-term, high-dose hydroxychloroquine corneal toxicity. 61
32346653 2020
20
Long-term Results of Intraocular Pressure Elevation and Post-DMEK Glaucoma After Descemet Membrane Endothelial Keratoplasty. 61
32558736 2020
21
The findings of corneal specular microscopy in patients with type-2 diabetes mellitus. 61
32493325 2020
22
MANF Promotes Diabetic Corneal Epithelial Wound Healing and Nerve Regeneration by Attenuating Hyperglycemia-Induced Endoplasmic Reticulum Stress. 61
32312869 2020
23
Lacrimal tissue resection in Fasanella Servat operation and the correlation to dry eye. 61
31393212 2020
24
Pathogenic Role of PPARα Downregulation in Corneal Nerve Degeneration and Impaired Corneal Sensitivity in Diabetes. 61
32213513 2020
25
Central Toxic Keratopathy after Small Incision Lenticule Extraction. 61
32495535 2020
26
Corneal Neurotization: A Surgical Treatment for Neurotrophic Keratopathy. 61
32349065 2020
27
Bowman's layer in the cornea- structure and function and regeneration. 61
32339517 2020
28
A Novel Approach of Harvesting Viable Single Cells from Donor Corneal Endothelium for Cell-Injection Therapy. 61
32526886 2020
29
Arthrographis kalrae Keratitis Complicated by Endophthalmitis: A Case Report With Literature Review. 61
32443014 2020
30
The Use of Sirolimus for Treatment of Orbital Lymphatic Malformations: A Systematic Review. 61
31990892 2020
31
Abnormal neovascular and proliferative conjunctival phenotype in limbal stem cell deficiency is associated with altered microRNA and gene expression modulated by PAX6 mutational status in congenital aniridia. 61
32422284 2020
32
Analysis of genotype-phenotype correlations in PAX6-associated aniridia. 61
32467297 2020
33
Development of the neurotrophic keratopathy questionnaire: qualitative research. 61
32367451 2020
34
Ectodermal Dysplasia: Association with Anti-Basement Membrane Autoantibodies. 61
31268817 2020
35
Finger-Prick Autologous Blood in the Treatment of Persistent Corneal Epithelial Defects. 61
31868852 2020
36
Evaluation of emulsified silicone oil with spectral domain-optical coherence tomography and fluorescein angiography. 61
32399773 2020
37
Tear Levels of IGFBP-3: A Potential Biomarker for Diabetic Nerve Changes in the Cornea. 61
32443005 2020
38
Reduced frequency of Intravitreal methotrexate injection lowers the risk of Keratopathy in Vitreoretinal lymphoma patients. 61
32397978 2020
39
Effects of Vitamin D Receptor Knockout and Vitamin D Deficiency on Corneal Epithelial Wound Healing and Nerve Density in Diabetic Mice. 61
32139594 2020
40
Differential effects of primary disease and corneal vascularisation on corneal transplant rejection and survival. 61
31462418 2020
41
Treatment of Congenital Ptosis in Infants With Associated Amblyopia Using a Frontalis Muscle Flap Eyelid Reanimation Technique. 61
32467524 2020
42
A technique for eyelid margin repair without use of marginal sutures. 61
32449417 2020
43
Development of Corneal Sensation With Remodeling of the Epithelium and the Palisades of Vogt After Corneal Neurotization. 61
31990849 2020
44
Toxic keratopathy associated with topical abuse of low-concentration anesthetics: A report of two cases. 61
32317478 2020
45
Comparison of the Clinical Efficacy of Boston Keratoprosthesis Type I and Repetitive Penetrating Keratoplasty for Refractory Keratopathy: Comment. 61
32398623 2020
46
In vivo evaluation of corneal nerves and epithelial healing after treatment with recombinant nerve growth factor for neurotrophic keratopathy. 61
32387431 2020
47
Protective effect of high-affinity liposomes encapsulating astaxanthin against corneal disorder in the in vivo rat dry eye disease model. 61
32523249 2020
48
Corneal Endothelial Cell Toxicity Determines Long-Term Outcome After Ocular Exposure to Sulfur Mustard Vapor. 61
32044824 2020
49
Graded transantral orbital decompression outcomes in stable thyroid eye disease: a series of 47 orbits. 61
32363975 2020
50
Management of corneal epithelial defects in a population of mature chuck-will's-widows (Antrostomus carolinensis) in South Florida. 61
32100932 2020

Variations for Keratopathy

Expression for Keratopathy

Search GEO for disease gene expression data for Keratopathy.

Pathways for Keratopathy

Pathways related to Keratopathy according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 TNF TGFB3 TGFB2 PAX6 OGFR ITGB1
2
Show member pathways
13.48 TNF TGFB3 TGFB2 OGFR ITGB1 IL4
3
Show member pathways
13.38 TNF TGFB3 TGFB2 ITGB1 IL4 IL1A
4
Show member pathways
13.27 TNF TGFB3 TGFB2 OGFR IL4 IL1A
5
Show member pathways
12.83 TNF IL4 IL1A ICAM1 CXCL8
6 12.82 TGFB3 TGFB2 ITGB1 IL4 IGF1 CXCL8
7 12.74 TNF TGFB3 TGFB2 IL1A IGF1
8
Show member pathways
12.72 TGFB3 TGFB2 NID1 ITGB1 ICAM1
9
Show member pathways
12.68 TNF TGFB3 TGFB2 OGFR IL1A IGF1
10
Show member pathways
12.57 TNF TGFB3 TGFB2 IL4 IL1A
11
Show member pathways
12.38 TGFB3 TGFB2 PAX6 ITGB1 IGF1
12 12.32 TNF TGFB3 TGFB2 ICAM1
13 12.28 TNF TGFB2 ITGB1 IGF1
14 12.25 TNF ITGB1 GAPDH CXCL8
15
Show member pathways
12.23 TNF TGFB3 TGFB2 ITGB1 IGF1
16
Show member pathways
12.23 TNF TGFB3 TGFB2 ITGB1 IL4 IL1A
17 12.21 TNF TGFB3 TGFB2 IL1A
18 12.14 TGFB3 TGFB2 IL1A CXCL8
19 12.12 TNF TACR1 TAC1 IL1A GAPDH CXCL8
20 11.91 TNF TGFB3 TGFB2 CXCL8
21 11.88 TNF TACR1 IL4 IL1A ICAM1 CXCL8
22 11.87 TGFB3 TGFB2 ITGB1 IGF1
23 11.82 TGFB3 TGFB2 ITGB1
24 11.79 TNF ITGB1 IL4 IL1A ICAM1 CXCL8
25 11.78 IL4 ICAM1 CXCL8
26
Show member pathways
11.77 TNF TGFB3 TGFB2 OGFR IL4 IL1A
27 11.76 TNF ITGB1 IL1A CXCL8
28
Show member pathways
11.74 TNF IL4 CXCL8
29
Show member pathways
11.72 TGFB3 TGFB2 ITGB1
30
Show member pathways
11.64 TNF IL1A ICAM1 CXCL8
31 11.63 TNF TGFB3 TGFB2 IL1A ICAM1 CXCL8
32 11.62 TNF IL4 IGF1 CXCL8
33 11.6 NID1 ITGB1 IGF1 CXCL8
34 11.59 TGFB3 TGFB2 ITGB1
35 11.5 TNF TGFB3 TGFB2 ICAM1 CXCL8
36 11.48 TNF IL1A IGF1
37 11.46 ITGB1 ICAM1 CXCL8
38 11.46 TNF IL4 IL1A ICAM1 CXCL8
39
Show member pathways
11.36 TNF TGFB3 TGFB2
40 11.25 TNF IL4 IL1A
41 11.07 TNF TGFB3 TGFB2 IL1A ICAM1 CXCL8
42 10.97 TGFB3 TGFB2 IL4
43 10.96 TNF TGFB3 TGFB2 ITGB1 IL4 IL1A
44 10.75 TGFB3 TGFB2 IL4
45 10.51 TACR1 TAC1

GO Terms for Keratopathy

Cellular components related to Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 TNF TGFB3 TGFB2 TAC1 NID1 LACRT
2 extracellular space GO:0005615 9.36 TNF TGFB3 TGFB2 TAC1 LACRT IL4
3 platelet alpha granule lumen GO:0031093 9.33 TGFB3 TGFB2 IGF1

Biological processes related to Keratopathy according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.15 TNF TGFB3 PAX6 IL4 IL1A IGF1
2 immune response GO:0006955 10.02 TNF IL4 IL1A CXCL8 AIRE
3 positive regulation of gene expression GO:0010628 10.02 TNF PAX6 IL4 IL1A IGF1
4 positive regulation of transcription, DNA-templated GO:0045893 10.02 TNF TGFB3 PAX6 IL4 IGF1 AIRE
5 inflammatory response GO:0006954 9.98 TNF TACR1 TAC1 IL1A CXCL8
6 positive regulation of cell proliferation GO:0008284 9.97 TGFB3 TGFB2 LACRT ITGB1 IL4 IGF1
7 extracellular matrix organization GO:0030198 9.93 TNF NID1 ITGB1 ICAM1
8 cellular response to lipopolysaccharide GO:0071222 9.88 TNF IL1A ICAM1 CXCL8
9 negative regulation of cell proliferation GO:0008285 9.85 TGFB3 TGFB2 PAX6 IL1A CYP1B1 CXCL8
10 positive regulation of angiogenesis GO:0045766 9.83 ITGB1 IL1A CYP1B1 CXCL8
11 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.81 TNF TGFB2 IGF1
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.79 TNF IL4 IGF1
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.77 TNF IGF1 AKR1B1
14 positive regulation of cell division GO:0051781 9.71 TGFB3 TGFB2 IL1A
15 negative regulation of neuroinflammatory response GO:0150079 9.63 IL4 IGF1
16 positive regulation of cytokine secretion GO:0050715 9.63 TNF IL1A GAPDH
17 cytokine-mediated signaling pathway GO:0019221 9.63 TNF ITGB1 IL4 IL1A ICAM1 CXCL8
18 positive regulation of JAK-STAT cascade GO:0046427 9.61 TNF CYP1B1 AKR1B1
19 tachykinin receptor signaling pathway GO:0007217 9.6 TACR1 TAC1
20 positive regulation of mononuclear cell migration GO:0071677 9.57 TNF IL4
21 negative regulation of macrophage cytokine production GO:0010936 9.56 TGFB3 TGFB2
22 detection of abiotic stimulus GO:0009582 9.51 TACR1 TAC1
23 embryonic digestive tract development GO:0048566 9.5 TNF TGFB2 CXCL8
24 negative regulation of alkaline phosphatase activity GO:0010693 9.48 TNF TGFB2
25 positive regulation of calcineurin-NFAT signaling cascade GO:0070886 9.43 TNF LACRT IGF1
26 uterine wall breakdown GO:0042704 9.4 TGFB3 TGFB2
27 salivary gland morphogenesis GO:0007435 9.13 TGFB3 TGFB2 PAX6
28 positive regulation of protein secretion GO:0050714 8.92 TGFB3 TGFB2 IL1A IGF1

Molecular functions related to Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 TGFB3 TGFB2 LACRT IL4 IGF1
2 type II transforming growth factor beta receptor binding GO:0005114 9.32 TGFB3 TGFB2
3 laminin-1 binding GO:0043237 9.26 NID1 LACRT
4 type III transforming growth factor beta receptor binding GO:0034714 9.16 TGFB3 TGFB2
5 cytokine activity GO:0005125 9.1 TNF TGFB3 TGFB2 IL4 IL1A CXCL8

Sources for Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....