Keratosis, Seborrheic disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

KERSEB MCID: KRT071 MIFTS: 50	Keratosis, Seborrheic (KERSEB) Categories: Cancer diseases, Genetic diseases, Rare diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Keratosis, Seborrheic

MalaCards integrated aliases for Keratosis, Seborrheic:

Name: Keratosis, Seborrheic ⁵⁸ ⁷⁷ ⁵⁴ ⁷⁶ ³⁰ ⁶ ⁴⁵ ⁴¹

Seborrheic Keratosis ¹² ⁵⁴ ⁵⁶ ¹⁵ ¹⁷ ⁷⁴

Keratosis, Seborrheic, Somatic ⁵⁸ ¹³

Keratosis Seborrheica ⁵⁴

Basal Cell Papilloma ⁵⁴

Kerseb ⁷⁶

Characteristics:

OMIM:

⁵⁸

Inheritance:
autosomal dominant form

HPO:

³³

keratosis, seborrheic:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the skin and subcutaneous tissue

Other disorders of the skin and subcutaneous tissue

Seborrhoeic keratosis

External Ids:

Disease Ontology ¹² DOID:6498

OMIM ⁵⁸ 182000

ICD9CM ³⁶ 702.1

MeSH ⁴⁵ D017492

NCIt ⁵¹ C9006

SNOMED-CT ⁶⁹ 25499005 50563003

ICD10 ³⁴ L82 L82.1

MedGen ⁴³ C0022603

SNOMED-CT via HPO ⁷⁰ 263681008 30285000 57019003

EFO ¹⁷ EFO_0005584

UMLS ⁷⁴ C0022603

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Summaries for Keratosis, Seborrheic

NIH Rare Diseases : ⁵⁴ Seborrheic keratosis is a benign (non cancerous) tumor found on the skin. Seborrheic keratoses are the most common benign tumor in older individuals. They usually appear as multiple small, flat or raised growths that range in color from white to black and are commonly found on the face, neck, chest, shoulders, and hands. They usually do not cause symptoms, but occasionally can itch and rub or catch on clothing, causing irritation. Scratching seborrheic keratoses or trying to pick them off the skin can result in a secondary infection. The cause of seborrheic keratosis is not well understood; however, a combination of environmental factors, such as sun exposure and genetic factors may play a role. Treatment may not be needed depending on the size and location of the seborrheic keratoses. When treatment is desired, topically applied creams and acids and surgery may be considered.

MalaCards based summary : Keratosis, Seborrheic, also known as seborrheic keratosis, is related to inverted follicular keratosis and vulvar seborrheic keratosis. An important gene associated with Keratosis, Seborrheic is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Gastric cancer and Glioma. The drugs Hydrogen peroxide and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are verrucae and Decreased shRNA abundance (Z-score < -2)

OMIM : ⁵⁸ Seborrheic keratoses are common benign epidermal lesion that can develop on any part of the body. (182000)

UniProtKB/Swiss-Prot : ⁷⁶ Keratosis, seborrheic: A common benign skin tumor. Seborrheic keratoses usually begin with the appearance of one or more sharply defined, light brown, flat macules. The lesions may be sparse or numerous. As they initially grow, they develop a velvety to finely verrucous surface, followed by an uneven warty surface with multiple plugged follicles and a dull or lackluster appearance.

Wikipedia : ⁷⁷ A seborrheic keratosis is a non-cancerous (benign) skin tumour that originates from cells in the outer... more...

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Related Diseases for Keratosis, Seborrheic

Diseases related to Keratosis, Seborrheic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)

#	Related Disease	Score	Top Affiliating Genes
1	inverted follicular keratosis	33.0	CLEC2A KRT17 MTOR
2	vulvar seborrheic keratosis	32.2	CDKN2A MTOR
3	keratosis	31.4	FGFR3 KRT10 PIK3CA
4	bowen's disease	30.9	KRT10 KRT17
5	acanthoma	30.8	KRT10 KRT17
6	nevus, epidermal	30.7	FGFR3 KRT10 PIK3CA
7	dowling-degos disease 1	30.5	FGFR3 KRT5
8	in situ carcinoma	30.4	CDKN2A KRT17 KRT5
9	eccrine acrospiroma	30.4	KRT10 KRT17
10	verrucous carcinoma	30.0	CDKN2A KRT10
11	epidermolytic hyperkeratosis	30.0	KRT10 KRT17 KRT5
12	papilloma	29.8	CDKN2A FGFR3 KRT10 KRT5
13	inflamed seborrheic keratosis	12.5
14	epidermodysplasia verruciformis 1	11.6
15	melanoacanthoma	11.6
16	clear cell acanthoma	11.6
17	squamous cell carcinoma	10.6
18	squamous cell carcinoma of the oral tongue	10.3	KRT10 PIK3CA
19	pancreatic neuroendocrine tumor	10.3	MTOR PIK3CA
20	malignant spiradenoma	10.3	KRT5 PIK3CA
21	clear cell adenofibroma	10.3	MTOR PIK3CA
22	hemimegalencephaly	10.3	MTOR PIK3CA
23	skin carcinoma	10.3
24	epidermolysis bullosa simplex with mottled pigmentation	10.3	KRT10 KRT5
25	malignant biphasic mesothelioma	10.3	KRT10 KRT5
26	ovarian clear cell adenocarcinoma	10.2	MTOR PIK3CA
27	breast adenomyoepithelioma	10.2	KRT5 PIK3CA
28	breast myoepithelial neoplasm	10.2	KRT5 PIK3CA
29	gastric squamous cell carcinoma	10.2	KRT10 KRT5
30	mycobacterium malmoense	10.2	CD1A CD1E
31	basal cell carcinoma, infundibulocystic	10.2	KRT10 KRT17
32	hypercarotenemia and vitamin a deficiency, autosomal dominant	10.2
33	keratomalacia	10.2
34	acute motor and sensory axonal neuropathy	10.2
35	dermatosis papulosa nigra	10.2	FGFR3 MTOR PIK3CA
36	steatocystoma multiplex	10.2	KRT10 KRT17
37	renal cell carcinoma, papillary, 1	10.2	FGFR3 MTOR PIK3CA
38	multifocal motor neuropathy	10.2	CD1A CD1E
39	malignant atrophic papulosis	10.2
40	dowling-degos disease	10.2
41	cutaneous ganglioneuroma	10.2
42	adenocarcinoma	10.2
43	merkel cell carcinoma	10.2
44	ganglioneuroma	10.2
45	psoriasis	10.2
46	lichen planus	10.2
47	epidermolysis bullosa simplex, dowling-meara type	10.2	KRT10 KRT5
48	malignant acrospiroma	10.2	CLEC2A KRT5
49	anal squamous cell carcinoma	10.2	CDKN2A PIK3CA
50	breast squamous cell carcinoma	10.2	KRT10 KRT5 PIK3CA

Comorbidity relations with Keratosis, Seborrheic via Phenotypic Disease Network (PDN):

Hypertension, Essential

Keratosis

Graphical network of the top 20 diseases related to Keratosis, Seborrheic:

Sources

Symptoms & Phenotypes for Keratosis, Seborrheic

Human phenotypes related to Keratosis, Seborrheic:

³³

#	Description	HPO Frequency	HPO Source Accession
1	verrucae ³³		HP:0200043

Symptoms via clinical synopsis from OMIM:

⁵⁸

Skin:
seborrheic keratoses
congenital seborrheic verrucae

Clinical features from OMIM:

182000

GenomeRNAi Phenotypes related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

²⁷ (show all 44)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-10	10.06	FGFR3
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-14	10.06	TGFB2
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-141	10.06	TGFB2
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-173	10.06	MTOR
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-216	10.06	PIK3CA
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-26	10.06	TGFB2
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-53	10.06	MTOR PIK3CA
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-59	10.06	FGFR3 TGFB2
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-60	10.06	FGFR3 MTOR PIK3CA TGFB2
10	Decreased shRNA abundance (Z-score < -2)	GR00366-A-71	10.06	TGFB2
11	Decreased shRNA abundance (Z-score < -2)	GR00366-A-72	10.06	TGFB2
12	Decreased viability	GR00055-A-2	9.93	MTOR PIK3CA
13	Decreased viability	GR00221-A-1	9.93	CDKN2A FGFR3 MTOR PIK3CA
14	Decreased viability	GR00221-A-2	9.93	FGFR3 PIK3CA
15	Decreased viability	GR00221-A-3	9.93	CDKN2A FGFR3
16	Decreased viability	GR00221-A-4	9.93	CDKN2A MTOR PIK3CA
17	Decreased viability	GR00342-S-1	9.93	MTOR
18	Decreased viability	GR00342-S-2	9.93	MTOR
19	Decreased viability	GR00402-S-2	9.93	CDKN2A FGFR3 MTOR PIK3CA
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	9.87	MTOR
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-107	9.87	KRT17 TGFB2
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	9.87	MTOR TGFB2
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	9.87	TGFB2
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	9.87	PIK3CA
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-133	9.87	TGFB2
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	9.87	TGFB2
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-157	9.87	PIK3CA
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	9.87	MTOR PIK3CA
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-166	9.87	KRT17 PIK3CA
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-174	9.87	KRT17
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.87	PIK3CA
32	Increased shRNA abundance (Z-score > 2)	GR00366-A-189	9.87	KRT17
33	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	9.87	PIK3CA
34	Increased shRNA abundance (Z-score > 2)	GR00366-A-196	9.87	KRT17 TGFB2
35	Increased shRNA abundance (Z-score > 2)	GR00366-A-198	9.87	KRT17
36	Increased shRNA abundance (Z-score > 2)	GR00366-A-199	9.87	KRT17
37	Increased shRNA abundance (Z-score > 2)	GR00366-A-215	9.87	TGFB2
38	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	9.87	KRT17 MTOR PIK3CA TGFB2
39	Increased shRNA abundance (Z-score > 2)	GR00366-A-45	9.87	KRT17
40	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	9.87	KRT17
41	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	9.87	KRT17 PIK3CA
42	Increased shRNA abundance (Z-score > 2)	GR00366-A-50	9.87	TGFB2
43	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	9.87	MTOR TGFB2
44	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.87	MTOR

MGI Mouse Phenotypes related to Keratosis, Seborrheic:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	no phenotypic analysis	MP:0003012	9.17	CDKN2A FGFR3 KRT17 KRT5 MAGED1 MTOR

Sources

Drugs & Therapeutics for Keratosis, Seborrheic

Drugs for Keratosis, Seborrheic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Hydrogen peroxide

Approved, Vet_approved

Phase 4,Phase 2

7722-84-1

784

Synonyms:

[OH(OH)]

Adeka super el

Albone

Albone 35

Albone DS

Anti-keim 50

Asepticper

Baquashock

CIX

Clarigel gold

Crestal whitestrips

Crystacide

Dentasept

Deslime LP

Dihydrogen dioxide

H2O2

Hioxyl

Hipox

HOOH

Hybrite

Hydrogen dioxide

Hydrogen peroxide (H2O2)

Hydroperoxide

Inhibine

Lase peroxide

Lensan a

Magic bleaching

Metrokur

Mirasept

Nite white excel 2

Odosat D

Opalescence xtra

Oxigenal

Oxydol

Oxyfull

Oxysept

Oxysept I

Pegasyl

Perhydrol

Perone

Peroxaan

Peroxclean

Peroxide, hydrogen

Quasar brite

Select bleach

Superoxol

T-Stuff

Whiteness HP

Whitespeed

Xtra white

Pharmaceutical Solutions

Phase 4,Phase 3,Phase 2,Phase 1

Everolimus

Approved

Phase 1, Phase 2

159351-69-6

6442177 70789204

Synonyms:

(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone

(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone

(1R,9S,12S,15R,16E,23S,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriacont

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34as)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethy

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

001, RAD

07741_FLUKA

159351-69-6

40-O-(2-hydroxyethyl)-rapamycin

40-O-(2-Hydroxyethyl)-rapamycin

42-O-(2-Hydroxyethyl)rapamycin

Afinitor

Certican

CERTICAN(R)

CHEMBL1201755

D02714

DB01590

everolimus

Everolimus

évérolimus

Everolimus (JAN/USAN/INN)

Everolimus [USAN]

LS-143292

MolPort-003-847-342

MolPort-003-925-588

NCGC00167512-01

NVP-RAD-001

RAD 001

RAD, SDZ

RAD001

RAD-001

RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus

RAD-001C

S1120_Selleck

SDZ RAD

SDZ-RAD

UNII-9HW64Q8G6G

Zortress

Miconazole

Approved, Investigational, Vet_approved

Phase 1, Phase 2

22916-47-8

4189

Synonyms:

(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole

1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole

1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole

1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole

1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole

1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole

1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole

1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole

1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole

22832-87-7 (NITRATE)

22916-47-8

75319-47-0

AB00053500

AC1L1HM1

Aflorix(nitrate)

AKOS001574474

Albistat(nitrate)

Andergin(nitrate)

BPBio1_000279

BRD-A82396632-001-03-0

BRD-A82396632-008-02-7

Brentan

BRN 0965511

BSPBio_000253

BSPBio_002033

CCRIS 7924

CHEBI:6923

CHEMBL91

CID4189

Conofite(nitrate)

CPD-4501

D00416

Dactarin

Daktarin IV

DB01110

DivK1c_000156

EINECS 245-324-5

Epi-Monistat(nitrate)

Esteve brand OF miconazole

Femizol-M

Florid(nitrate)

Gyno-Daktar(nitrate)

HMS1568M15

HMS2090B21

I14-14342

IDI1_000156

imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)

Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)

Janssen cilag brand OF miconazole

Janssen-cilag brand OF miconazole

Johnston and johnston brand OF miconazole nitrate

KBio1_000156

KBio2_001445

KBio2_004013

KBio2_006581

KBio3_001533

KBioGR_000581

KBioSS_001445

Lotrimin AF(nitrate)

LS-78378

MCZ

Micantin (nitrate)

Miconasil nitrate

Miconasil Nitrate

Miconazol

Miconazol [INN-Spanish]

miconazole

Miconazole

Miconazole (JP15/USP/INN)

Miconazole [USAN:BAN:INN:JAN]

Miconazole 3

Miconazole 3 Combination Pack

Miconazole 7 Combination Pack

Miconazole esteve brand

Miconazole janssen-cilag brand

Miconazole nitrate

Miconazole nitrate salt

Miconazole-7

Miconazolo

Miconazolo [DCIT]

Miconazolum

Miconazolum [INN-Latin]

Micozole

Minostate

MJR 1762

MLS002222203

MolPort-002-557-553

Monazole 7

Monista (nitrate)

Monistat

Monistat (TN)

Monistat 1 Combination Pack

Monistat 3 Dual-Pak

Monistat 3 Vaginal Ovules

Monistat 5 Tampon

Monistat 7 Dual-Pak

Monistat 7 Vaginal Suppositories

Monistat Dual- PAK

Monistat IV

Monistat iv (TN)

Monistat-Derm

NCI60_001353

NCI60_001380

NINDS_000156

Nitrate, miconasil

Nitrate, miconazole

Novo-Miconazole Vaginal Ovules

NSC 170986

NSC169434

NSC170986

Oprea1_091955

Prestwick_335

Prestwick0_000067

Prestwick1_000067

Prestwick2_000067

Prestwick3_000067

R 18134

R-14,889

SMR001307249

SPBio_000976

SPBio_002174

Spectrum_000965

Spectrum2_001048

Spectrum3_000507

Spectrum4_000061

Spectrum5_001297

STK834405

STOCK1S-93556

UNII-7NNO0D7S5M

Vusion

Zimycan

Sirolimus

Approved, Investigational

Phase 1, Phase 2

53123-88-9

46835353 6436030 5284616

Synonyms:

(-)-rapamycin

(-)-Rapamycin

1fkb

1pbk

23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine

23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine

23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29

3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

53123-88-9

A422989, NSC226080

AC1L1JH9

AC1L7MJ9

AC1L9ZMV

AC-722

Ambotz53123-88-9

Antibiotic AY 22989

AY 22989

AY22989

AY-22989

BIDD:PXR0165

Bio1_000293

Bio1_000782

Bio1_001271

Bio2_000375

Bio2_000855

BiomolKI2_000084

C07909

C51H79NO13

CBiol_002007

CCRIS 9024

CHEBI:100923

CHEBI:9168

CHEMBL413

CID10213190

CID10795871

CID11949238

CID11959112

CID313006

CID478951

CID5040

CID5284616

CID5358081

CID5374464

CID5460439

CID5497196

CID5924240

CID6436030

CID6610270

CID6610346

CID6711160

CID6713081

CID9833581

CID9854379

CID9854380

CID9962926

CID9962928

D00753

DB00877

DE-109

DivK1c_006936

FT-0082351

heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy

HMS2089A21

HSDB 7284

KBio1_001880

KBio2_000410

KBio2_002978

KBio2_005546

KBio3_000779

KBio3_000780

KBioGR_000410

KBioSS_000410

LCP-Siro

LMPK06000003

LS-143290

MLS000028373

MolMap_000043

MolPort-003-959-433

MS-R001

NCGC00021305-05

nchembio.100-comp4

nchembio.2007.42-comp2

nchembio.79-comp1

nchembio762-comp1

nchembio883-comp3

NCI60_001851

NCIMech_000355

NSC 226080

NSC226080

Perceiva

QTL1_000069

R0395_SIAL

R0395_SIGMA

RAP

RAPA

Rapammune

Rapamune

Rapamune (TN)

rapamycin

Rapamycin

Rapamycin (TN)

Rapamycin C-7, analog 4

Rapamycin from Streptomyces hygroscopicus

Rapamycin Immunosuppressant Drug

RPM

S1039_Selleck

SIIA 9268A

SILA 9268A

SILA9268A

sirolimus

Sirolimus

Sirolimús

Sirolimus (RAPAMUNE)

Sirolimus (USAN/INN)

Sirolimus [USAN:BAN:INN]

Sirolimus, Rapamune,Rapamycin

Sirolimusum

SMP1_000255

SMR000058564

SpecPlus_000840

UNII-W36ZG6FT64

UNM-0000358684

Wy 090217

WY-090217

Antifungal Agents

Phase 1, Phase 2

Immunologic Factors

Phase 1, Phase 2

Antibiotics, Antitubercular

Phase 1, Phase 2

Anti-Bacterial Agents

Phase 1, Phase 2

Anti-Infective Agents

Phase 1, Phase 2

Immunosuppressive Agents

Phase 1, Phase 2

Epinephrine

Approved, Vet_approved

Not Applicable

51-43-4

5816

Synonyms:

(−)-(R)-epinephrine

(-)-(R)-Epinephrine

(-)-3,4-Dihydroxy-a-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-a-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol

(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-alpha-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol

(−)-3,4-dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-Adrenalin

(−)-adrenaline

(-)-Adrenaline

(-)-Epinephrine

(-)-R-Epinephrine

(R)-(-)-Adnephrine

(R)-(−)-adrenaline

(R)-(-)-Adrenaline

(R)-(-)-Epinephrine

(R)-(-)-Epirenamine

(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

(R)-Adrenaline

(R)-Epinephrine

02252_FLUKA

1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

1-Adrenalin

1-Epinephrine

4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol

4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol

51028-73-0

51-43-4

51-43-4 (FREE BASE)

A0173

AC-13188

AC1L1L7B

Acetate, epinephrine

Adnephrine

ADR ADRENALINE

Adrenal

Adrenalin

Adrenalin (TN)

Adrenalin in Oil

Adrenalina

Adrenalina [DCIT]

adrenaline

Adrenaline

Adrénaline

Adrenaline (JP15)

Adrenaline acid tartrate

Adrenaline bitartrate

Adrenaline hydrochloride

Adrenaline/Epinephrine

Adrenalin-Medihaler

Adrenalinum

Adrenamine

Adrenan

Adrenapax

Adrenasol

Adrenatrate

Adrenine

Adrenodis

Adrenohorma

Adrenosan

Adrenutol

Adrin

Adrine

ADROP

AI3-19015

Allergan brand OF adrenaline hydrochloride

Ana-Guard

Ana-kit

Antiasthmatique

Asmatane Mist

Asthma meter mist

Asthmahaler Mist

Asthmanefrin

Asthma-nefrin

Astmahalin

Astminhal

Balmadren

Bernarenin

BIDD:GT0119

Biorenine

bmse000316

Bosmin

Brevirenin

Bronkaid

Bronkaid mist

Bronkaid Mist

Bronkaid Suspension Mist

Bupivacaine Hcl and Epinephrine

C00788

CCRIS 4812

CHEBI:28918

Chelafrin

CHEMBL679

CID5816

Citanest Forte

Corisol

D00095

d-Adrenaline

DB00668

D-Epifrin

D-Epinephrine

Drenamist

Dylephrin

Dyspne-Inhal

E4250_SIGMA

EINECS 200-098-7

EPI E Z PEN JR

Epi EZ Pen Jr

Epifrin

Epiglaufrin

Epinefrin

Epinefrin [Czech]

Epinefrina

Epinefrina [INN-Spanish]

Epinephran

Epinephrin

epinephrine

Epinephrine

Epinephrine (USP)

Epinephrine (USP/INN)

Epinephrine [USAN:INN:JAN]

Epinephrine acetate

Epinephrine bitartrate

Epinephrine hydrochloride

Epinephrine hydrogen tartrate

Epinephrinum

Epinephrinum [INN-Latin]

Epipen

Epipen (TN)

Epipen Auto-Injector

EPIPEN E Z PEN

Epipen EZ Pen

Epipen JR

EPIPEN JR

Epipen Jr.

Epipen Jr. Auto-Injector

Epirenamine

Epirenan

Epirenin

Epitrate

Eppy

Esphygmogenina

Exadrin

Glaucon

Glaucosan

Glauposine

Glycirenan

Haemostasin

Haemostatin

Hektalin

Hemisine

Hemostasin

Hemostatin

HSCI1_000215

HSDB 4289

Hypernephrin

Hyporenin

Intranefrin

Iontocaine

IOP

Isoptoepinal

Kidoline

l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

l-Adrenalin

l-Adrenaline

L-Adrenaline

L-Adrenaline Base

L-Epinehphrine

l-Epinephine

L-epinephrine

L-Epinephrine

l-Epinephrine (synthetic)

l-Epirenamine

L-Epirenamine

Levoadrenaline

Levoepinephrine

Levo-Methylaminoethanolcatechol

Levorenen

Levorenin

Levorenine

Levoreninum

l-Methylaminoethanolcatechol

L-Methylaminoethanolcatechol

Lopac-E-4642

LS-156

Lyodrin

Lyophrin

Medihaler-epi

Medihaler-Epi

Metanephrin

Methylaminoethanolcatechol

Methylarterenol

Micronefrin

Micronephrine

MolPort-002-051-368

Mucidrina

Myosthenine

Mytrate

NCGC00015417-01

NCGC00142615-01

NCGC00142615-03

NCGC00142615-04

NCGC00142615-05

NCGC00142615-06

NCGC00142615-07

nchembio747-comp9

Nephridine

Nieraline

NSC 62786

NSC62786

Paranephrin

PDSP1_001120

PDSP2_001104

Primatene

Primatene mist

Primatene Mist

R-(-)-Epinephrine

Racemic Epinephrine

Racepinephrine

R-Adrenaline

RCRA waste no. P042

Rcra waste number P042

Renagladin

Renaglandin

Renaglandulin

Renaleptine

Renalina

Renoform

Renostypricin

Renostypticin

Renostyptin

Scurenaline

Septocaine

Simplene

Sindrenina

SMP1_000227

Soladren

Sphygmogenin

ST069368

Stryptirenal

Styptirenal

Supracapsulin

Supradin

Supranefran

Supranephrane

Supranephrine

Supranol

Suprarenaline

Suprarenin

Suprel

Surenine

Surrenine

Susphrine

Sus-phrine

Sus-Phrine

SUS-PHRINE SULFITE-FREE

Sympathin I

Takamina

Takamine

Tokamina

Tonogen

Twinject

Twinject 0.15

Twinject 0.3

Twinject 0.30

UNII-YKH834O4BH

Vaponefrin

Vasoconstrictine

Vasoconstrictor

Vasodrine

Vasoton

Vasotonin

Lidocaine

Approved, Vet_approved

Not Applicable

137-58-6

3676

Synonyms:

.alpha.-(Diethylamino)-2,6-acetoxylidide

.alpha.-Diethylamino-2,6-dimethylacetanilide

.alpha.-Diethylaminoaceto-2,6-xylidide

.omega.-Diethylamino-2,6-dimethylacetanilide

137-58-6

2-(diethylamino)-2',6'-Acetoxylidide

2-(Diethylamino)-2',6'-acetoxylidide

2-(diethylamino)-N-(2,6-Dimethylphenyl)acetamide

2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide

2-2ETN-2MePhAcN

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide

2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide

4-12-00-02538 (Beilstein Handbook Reference)

6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))

6108-05-0 (mono-hydrochloride, mono-hydrate)

73-78-9 (mono-hydrochloride)

AB00053581

AC-10282

AC1L1GGQ

AC1Q2Z7J

a-diethylamino-2,6-Dimethylacetanilide

After Burn Double Strength Gel

After Burn Double Strength Spray

After Burn Gel

After Burn Spray

AKOS001026768

alfa-Dietilamino-2,6-dimetilacetanilide

alfa-Dietilamino-2,6-dimetilacetanilide [Italian]

Alphacaine

alpha-diethylamino-2,6-dimethylacetanilide

alpha-diethylamino-2,6-Dimethylacetanilide

alpha-Diethylamino-2,6-dimethylacetanilide

Anestacon

Anestacon Jelly

ARONIS23855

Astrazeneca brand OF lidocaine

BIDD:GT0342

Bio-0767

Bio1_000379

Bio1_000868

Bio1_001357

Bio2_000079

Bio2_000559

BPBio1_000197

BRD-K52662033-001-02-6

BRD-K52662033-003-05-5

BRN 2215784

BSPBio_000179

BSPBio_001359

BSPBio_003004

C07073

C14H22N2O

Cappicaine

CAS-73-78-9

CDS1_000283

CHEBI:6456

CHEMBL79

CID3676

Cito optadren

CPD000058189

Cuivasil

D00358

Dalcaine

DB00281

Dentipatch

Dentipatch (TN)

DermaFlex

Diethylaminoaceto-2,6-xylidide

Dilocaine

DivK1c_000174

DivK1c_001323

Duncaine

EINECS 205-302-8

ELA-Max

EMBOLEX

Emla Cream

Esracaine

FT-0082378

Gravocain

HMS1791D21

HMS1989D21

HMS2051C21

HMS2089E15

HMS548M19

HSDB 3350

I01-2704

IDI1_000174

IDI1_033829

Isicaina

Isicaine

Jenapharm brand OF lidocanine hydrochloride

Jetocaine

KBio1_000174

KBio2_000079

KBio2_001598

KBio2_002647

KBio2_004166

KBio2_005215

KBio2_006734

KBio3_000157

KBio3_000158

KBio3_002224

KBioGR_000079

KBioGR_000599

KBioSS_000079

KBioSS_001598

L0156

L1026_SIGMA

L7757_SIGMA

Lanabiotic

L-Caine

Leostesin

Lida-Mantle

Lidocaina

Lidocaína

Lidocaina [INN-Spanish]

lidocaine

Lidocaine

LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)

Lidocaine (JP15/USP/INN)

Lidocaine (VAN)

Lidocaine [USAN:INN:JAN]

Lidocaine carbonate

Lidocaine Carbonate

Lidocaine carbonate (2:1)

Lidocaine hydrocarbonate

Lidocaine Hydrocarbonate

Lidocaine hydrochloride

Lidocaine monoacetate

Lidocaine monohydrochloride

Lidocaine Monohydrochloride

Lidocaine monohydrochloride, monohydrate

Lidocaine sulfate (1:1)

Lidocainum

Lidocainum [INN-Latin]

Lidocaton

Lidoderm

Lidoject-1

Lidoject-2

LIDOPEN

Lignocaine

Lignocainum

Lingocaine

Lopac0_000669

Lopac-L-5647

LQZ

LS-805

Maricaine

Maybridge1_002571

MLS000069724

MLS000758263

MLS001074177

MolPort-001-783-478

N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide

N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide

NCGC00015611-01

NCGC00015611-02

NCGC00015611-03

NCGC00015611-04

NCGC00015611-14

NCGC00022176-05

NCGC00022176-06

NCGC00022176-07

NCGC00022176-08

NCGC00022176-09

nchembio.65-comp16

NINDS_000174

Norwood Sunburn Spray

Novocol brand OF lidocaine hydrochloride

NSC 40030

NSC40030

Octocaine

Octocaine-100

Octocaine-50

Prestwick0_000050

Prestwick1_000050

Prestwick2_000050

Prestwick3_000050

Remicaine

Rocephin Kit

Rucaina

S1357_Selleck

SAM001247018

SMR000058189

Solarcaine aloe extra burn relief cream

Solcain

SPBio_001525

SPBio_002100

Spectrum_001118

Spectrum2_001343

Spectrum3_001392

Spectrum4_000070

Spectrum5_001549

STK552033

Strathmann brand OF lidocaine hydrochloride

UNII-98PI200987

WLN: 2N2 & 1VMR B1 F1

Xilina

Xilocaina

Xilocaina [Italian]

Xllina

Xycaine

Xylestesin

Xylesthesin

Xylocain

Xylocaine

Xylocaine (TN)

Xylocaine 5% Spinal

Xylocaine CO2

Xylocaine Dental Ointment

Xylocaine Endotracheal

Xylocaine Test Dose

Xylocaine Viscous

Xylocaine-Mpf

Xylocaine-Mpf with Glucose

Xylocard

Xylocitin

Xyloneural

Xyloneural (free base)

Xylotox

Zilactin-L

Zingo

α-diethylamino-2,6-dimethylacetanilide

Racepinephrine

Approved

Not Applicable

329-65-7

838

Synonyms:

(+-)-Adrenaline

(+-)-Epinephrine

2-(methylamino)-1-(3,4-Dihydroxyphenyl)ethanol

Adrenaline hydrochloride, racemic mixture

Adrenaline, racemic

Adrenaline, racemic mixture

Bird brand OF racepinefrine hydrochloride

DL-Adrenaline

Epinephrine hydrochloride, racemic mixture

Epinephrine racemic

Epinephrine, racemic

Epinephrine, racemic mixture

Hydrochloride, racepinephrine

Micronefrin

Micronephrine

Mixture adrenaline, racemic

Mixture epinephrine, racemic

Racemic adrenaline

Racemic epinephrine

Racemic mixture adrenaline

Racemic mixture epinephrine

Racepinefrina

Racepinefrine

Racepinefrinum

Racepinephrine

Racepinephrine hydrochloride

Vaponefrin

Anesthetics

Not Applicable

Epinephryl borate

Not Applicable

Interventional clinical trials:

(show all 17)

#	Name	Status	NCT ID	Phase	Drugs
1	An A Study Assessing Subject Satisfaction With A-101 Topical Solution for Seborrheic Keratoses	Completed	NCT03487588	Phase 4	A-101 Topical Solution
2	A Study of A-101 Solution 40% in Subjects With Seborrheic Keratosis.	Completed	NCT02667236	Phase 3	A-101 Solution
3	A Randomized, Double-Blind, Vehicle-Controlled Study in Subjects With Seborrheic Keratosis	Completed	NCT02667275	Phase 3	A-101 Solution
4	An Open-Label Safety Study of A-101 Solution	Completed	NCT02667288	Phase 3	A-101 Solution
5	Study to Evaluate the Safety and Efficacy of PEP005(Ingenol Mebutate) Gel, 0.05%, in Patients With Seborrhoeic Keratosis	Completed	NCT01214564	Phase 2	PEP005 (ingenol mebutate) Gel
6	Dose-Response Profile of A-101 in Subjects With Seborrheic Keratosis	Completed	NCT02160626	Phase 2	A-101 Vehicle;A-101 (40) Topical Solution;A-101 (32.5) Topical Solution
7	Study of Safety, Tolerability and Effectiveness of A-101 in Subjects With Seborrheic Keratosis	Completed	NCT01986920	Phase 1, Phase 2	A-101 25%;A-101 32.5%;A-101 40%;A-101 Vehicle
8	A Randomized, Vehicle-Controlled Study of 2 Concentrations of A-101 for the Treatment of Seborrheic Keratosis	Completed	NCT03148691	Phase 2	A-101
9	Study of A-101 for the Treatment of Seborrheic Keratosis	Completed	NCT02260180	Phase 2	A-101
10	Novel Compositions for Treating or Preventing Dermal Disorders	Recruiting	NCT03103893	Phase 1, Phase 2	Rapamycin
11	In-vivo Optical Coherence Tomography Imaging in Dermatooncology	Unknown status	NCT01680562
12	Nano-Pulse Stimulation (NPS) in Seborrheic Keratosis Study	Completed	NCT03846531	Not Applicable
13	Is Cryosurgery or Curettage More Effective at Treating Seborrheic Keratoses?	Completed	NCT01159860	Not Applicable
14	Dermatosis Papulosa Nigra	Completed	NCT00710203	Not Applicable
15	Optical Biopsy of Human Skin in Conjunction With Laser Treatment	Completed	NCT00540566
16	Analysis of Melanocytes (Pigment Cells) in Sun-Exposed Skin	Completed	NCT00875381
17	Electrocautery vs Q-switch for Seborrheic Keratosis	Withdrawn	NCT02366559	Not Applicable

Search NIH Clinical Center for Keratosis, Seborrheic

Cochrane evidence based reviews: keratosis, seborrheic

Sources

Genetic Tests for Keratosis, Seborrheic

Genetic tests related to Keratosis, Seborrheic:

#	Genetic test	Affiliating Genes
1	Keratosis, Seborrheic ³⁰	PIK3CA

Sources

Anatomical Context for Keratosis, Seborrheic

MalaCards organs/tissues related to Keratosis, Seborrheic:

⁴²

Skin

Sources

Publications for Keratosis, Seborrheic

Articles related to Keratosis, Seborrheic:

(show top 50) (show all 51)

#	Title	Authors	Year
1	Endoscopic Submucosal Dissection of Seborrheic Keratosis-Like Lesion of the Esophagus: A New Entity? ( 30632124 )	Ekinci N...Aslan F	2019
2	The Many Faces of Seborrheic Keratosis. ( 30846163 )	Carrera C	2019
3	Ki-67 and p16 Immunostaining Differentiates Pagetoid Bowen Disease From "Microclonal" Seborrheic Keratosis. ( 30852607 )	Bahrani E...Pincus LB	2019
4	Verrucous melanoma masquerading as a seborrheic keratosis. ( 30865414 )	Tran PT...Levins P	2019
5	Seborrheic keratosis-like lesions localized to tattoo. ( 30891479 )	Bakke JR...Jones A	2019
6	Secondary Ossification Associated with Seborrheic Keratosis Adjacent to Basal Cell Carcinoma. ( 30078887 )	Ishikawa M...Yamamoto T	2018
7	Differentiation of seborrheic keratosis from basal cell carcinoma, nevi and melanoma by RGB autofluorescence imaging. ( 29675324 )	Lihachev A...Spigulis J	2018
8	Collision tumor: pigmented Bowen's disease and seborrheic keratosis. ( 30156629 )	Fernandes KAP...Campos-do-Carmo G	2018
9	An Unusual Childhood "Mole": Pigmented Basal Cell Cancer Mimicking Macular Seborrheic Keratosis. ( 28978228 )	Vangipuram R...Tyring SK	2018
10	Two cases of seborrheic keratosis of the external ear canal: involvement of PIK3CA and FGFR3 genes. ( 29485181 )	De Loof M...Dhooge I	2018
11	The status of the seborrheic keratosis. ( 29566932 )	Karadag AS...Parish LC	2018
12	Merkel cell carcinoma with seborrheic keratosis: A unique association. ( 29567894 )	Anand MS...Ranganathan J	2018
13	Ex vivo evaluation of cytotoxicity and melanocyte viability after A-101 hydrogen peroxide topical solution 40% or cryosurgery treatment in seborrheic keratosis lesions. ( 29601933 )	Kao S...Friedman A	2018
14	Distinguishing between irritated seborrheic keratosis and squamous cell carcinoma in situ using BCL-2 and IMP3 immunohistochemistry. ( 29726030 )	Richey JD...Cornejo KM	2018
15	Managing Seborrheic Keratosis: Evolving Strategies and Optimal Therapeutic Outcomes. ( 30235378 )	Kao S...Friedman AJ	2018
16	Giant perianal Seborrheic keratosis: A case report. ( 30243263 )	Salah B...Al-Rawashdeh B	2018
17	Porocarcinoma with hidroacanthoma simplex-like features in association with seborrheic keratosis. ( 28468734 )	Miura K...Yokozeki H	2017
18	Clonal Seborrheic Keratosis Versus Pagetoid Bowen Disease: Histopathology and Role of Adjunctive Markers. ( 28475506 )	Kalegowda IY...B?er-Auer A	2017
19	Erratum to: Increasing Frequency of Seborrheic Keratosis Diagnoses as a Favorable Consequence of Teledermatology-Based Skin Cancer Screening: A Cross-sectional Study of 34,553 Patients. ( 28488240 )	Moreno-Ram?rez D...Ferr?ndiz L	2017
20	Sebaceoma associated with seborrheic keratosis. ( 28730249 )	Fernandez-Flores A...Manj?n JA	2017
21	Irritated Subtype of Seborrheic Keratosis in the External Auditory Canal. ( 29069875 )	Park JK...Lee JJ	2017
22	Dermoscopy Improves the Diagnostic Accuracy of Melanomas Clinically Resembling Seborrheic Keratosis: Cross-Sectional Study of the Ability to Detect Seborrheic Keratosis-Like Melanomas by a Group of Dermatologists with Varying Degrees of Experience. ( 29502116 )	Carrera C...Zalaudek I	2017
23	Giant seborrheic keratosis of the genitalia with an unusual histopathological finding. ( 30148273 )	Seethalakshmi GV...Kannan G	2017
24	Clinical study of a retinoic acid-loaded microneedle patch for seborrheic keratosis or senile lentigo. ( 26757104 )	Hirobe S...Nakagawa S	2017
25	Intraepidermal proliferation of Merkel cells within a seborrheic keratosis: Merkel cell carcinoma in situ or Merkel cell hyperplasia? ( 28105724 )	McFalls J...Lee JB	2017
26	The role of immunosuppression in squamous cell carcinomas arising in seborrheic keratosis. ( 28162852 )	Conic RZ...Atanaskova Mesinkovska N	2017
27	Seborrheic keratosis arising on an epidermal nevus with HRAS p.G13R mutation. ( 28247919 )	Kitamura S...Shimizu H	2017
28	Dermoscopic Clues for Diagnosing Melanomas That Resemble Seborrheic Keratosis. ( 28355453 )	Carrera C...Zalaudek I	2017
29	Seborrheic keratosis with basal clear cells: Report of a case and review of the literature. ( 28401581 )	Manzotti C...Gonz?lez C?mpora R	2017
30	Dermoscopy-pathology relationship in seborrheic keratosis. ( 28447350 )	Minagawa A	2017
31	Squamous Cell Carcinoma in-situ and Basal Cell Carcinoma Arising From Seborrheic Keratosis in the Same Patient. ( 26955160 )	Gupta D...Thappa DM	2016
32	Classification of the Seborrheic Keratosis. ( 26353851 )	Coyne JD	2016
33	Further Advances in the Classification of the Seborrheic Keratosis. ( 26721306 )	Coyne JD	2016
34	Sustained Akt Activity Is Required to Maintain Cell Viability in Seborrheic Keratosis, a Benign Epithelial Tumor. ( 26739095 )	Neel VA...Mandinova A	2016
35	Unusual Dermoscopic Patterns of Seborrheic Keratosis. ( 26812275 )	Squillace L...Argenziano G	2016
36	Pigmented eccrine poroma of the palm clinically mimicking a seborrheic keratosis. ( 27222880 )	MeiQi May L...Chen-Wee Derrick A	2016
37	Diclofenac gel may be a new treatment option for seborrheic keratosis. ( 27294065 )	Akta? H...Kesero?lu H?	2016
38	Pigmented seborrheic keratosis showing starburst pattern. ( 27317533 )	Minagawa A...Okuyama R	2016
39	Dermatofibroma simulating seborrheic keratosis dermoscopically. ( 27438205 )	Barroso DH...Cavalcanti SM	2016
40	Cutaneous horn masquerading as a seborrheic keratosis. ( 29503929 )	Chen S...Song W	2016
41	Basal cell carcinoma showing surface hyperkeratosis clinically mimicking seborrheic keratosis. ( 26365209 )	Yanagihara S...Yamamoto O	2015
42	Basal Cell Carcinoma and Seborrheic Keratosis: When Opposites Attract. ( 26135529 )	Fusco N...Gianelli U	2015
43	Dermoscopic features of hidroacanthoma simplex: Usefulness in distinguishing it from Bowen's disease and seborrheic keratosis. ( 25989988 )	Shiiya C...Shimizu H	2015
44	Dermoscopy of clonal seborrheic keratosis. ( 26183995 )	Ramyead S...Pozo-Garcia L	2015
45	Extraocular sebaceous carcinoma in association with a clonal seborrheic keratosis: Dermoscopic features. ( 26248863 )	Iikawa M...Yokozeki H	2015
46	Invasive Squamous Cell Carcinoma With Clear Cell Change of the Eyelid Arising in a Seborrheic Keratosis. ( 26426916 )	Stagner AM...Iwamoto MA	2015
47	Management of benign skin lesions commonly affecting the face: actinic keratosis, seborrheic keratosis, and rosacea. ( 19465852 )	Brodsky J.	2009
48	Verruciform xanthoma-like phenomenon in seborrheic keratosis. ( 16640546 )	Wu YH...Lin YC	2006
49	A comparison of dermoscopic features among lentigo senilis/initial seborrheic keratosis, seborrheic keratosis, lentigo maligna and lentigo maligna melanoma on the face. ( 15729860 )	Sahin M.T....GA1neA9 A.T.	2004
50	Image analysis for quantification of nucleolar organizer regions in basal cell carcinoma and seborrheic keratosis. ( 27326718 )	Lee SY...Oh CH	1995

Sources

Genes for Keratosis, Seborrheic

Genes related to Keratosis, Seborrheic (2 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1332.02	Molecular basis known ⁵⁸ Pathogenic ⁶ Causative variation ⁷⁶ Genetic Tests ³⁰ DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)	15016963 15520168 15608678 (more) 17673550 22658544 22729222 23100325 26266975 26266985 22729224 22729223
2	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	742.48	Pathogenic ⁶ Causative variation ⁷⁶ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Variants (show sections)	8589699 10471491 15772091 (more) 7773297 8858131 9677066 10073901 11529856 12833394 16841094 18642369 17585316 16778799 17392824 17673550 15772091 20420824 18728396 17255960 17172848 17568799
3	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	17.39	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶	9178800
4	KRT10	Keratin 10	Protein Coding	15.6	DISEASES inferred ¹⁵
5	MAGED1	MAGE Family Member D1	Protein Coding	15.2	DISEASES inferred ¹⁵
6	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	15.17	DISEASES inferred ¹⁵
7	CD1E	CD1e Molecule	Protein Coding	15.15	DISEASES inferred ¹⁵
8	KRT5	Keratin 5	Protein Coding	14.82	DISEASES inferred ¹⁵
9	CD1A	CD1a Molecule	Protein Coding	14.77	DISEASES inferred ¹⁵
10	KRT17	Keratin 17	Protein Coding	14.72	DISEASES inferred ¹⁵
11	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	14.71	DISEASES inferred ¹⁵
12	DPH3	Diphthamide Biosynthesis 3	Protein Coding	5.64	DISEASES inferred ¹⁵
13	CLEC2A	C-Type Lectin Domain Family 2 Member A	Protein Coding	5.5	DISEASES inferred ¹⁵

Sources

Variations for Keratosis, Seborrheic

UniProtKB/Swiss-Prot genetic disease variations for Keratosis, Seborrheic:

⁷⁶ (show all 11)

#	Symbol	AA change	Variation ID	SNP ID
1	FGFR3	p.Arg248Cys	VAR_004148	rs121913482
2	FGFR3	p.Ser249Cys	VAR_004149	rs121913483
3	FGFR3	p.Gly370Cys	VAR_004151	rs121913479
4	FGFR3	p.Ser371Cys	VAR_004152	rs121913484
5	FGFR3	p.Tyr373Cys	VAR_004153	rs121913485
6	FGFR3	p.Lys650Glu	VAR_004160	rs78311289
7	FGFR3	p.Lys650Met	VAR_004161	rs121913105
8	PIK3CA	p.Glu542Lys	VAR_026173	rs121913273
9	PIK3CA	p.Glu545Gly	VAR_026177	rs121913274
10	PIK3CA	p.Glu545Lys	VAR_026178	rs104886003
11	PIK3CA	p.His1047Arg	VAR_026192	rs121913279

ClinVar genetic disease variations for Keratosis, Seborrheic:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	PIK3CA	NM_006218.3(PIK3CA): c.3140A> G (p.His1047Arg)	single nucleotide variant	Pathogenic	rs121913279	GRCh37	Chromosome 3, 178952085: 178952085
2	PIK3CA	NM_006218.3(PIK3CA): c.3140A> G (p.His1047Arg)	single nucleotide variant	Pathogenic	rs121913279	GRCh38	Chromosome 3, 179234297: 179234297
3	PIK3CA	NM_006218.3(PIK3CA): c.1633G> A (p.Glu545Lys)	single nucleotide variant	Pathogenic/Likely pathogenic	rs104886003	GRCh37	Chromosome 3, 178936091: 178936091
4	PIK3CA	NM_006218.3(PIK3CA): c.1633G> A (p.Glu545Lys)	single nucleotide variant	Pathogenic/Likely pathogenic	rs104886003	GRCh38	Chromosome 3, 179218303: 179218303
5	PIK3CA	NM_006218.3(PIK3CA): c.1633G> A (p.Glu545Lys)	single nucleotide variant	Pathogenic/Likely pathogenic	rs104886003	NCBI36	Chromosome 3, 180418785: 180418785
6	FGFR3	NM_000142.4(FGFR3): c.742C> T (p.Arg248Cys)	single nucleotide variant	Pathogenic	rs121913482	GRCh37	Chromosome 4, 1803564: 1803564
7	FGFR3	NM_000142.4(FGFR3): c.742C> T (p.Arg248Cys)	single nucleotide variant	Pathogenic	rs121913482	GRCh38	Chromosome 4, 1801837: 1801837
8	FGFR3	NM_000142.4(FGFR3): c.746C> G (p.Ser249Cys)	single nucleotide variant	Pathogenic	rs121913483	GRCh37	Chromosome 4, 1803568: 1803568
9	FGFR3	NM_000142.4(FGFR3): c.746C> G (p.Ser249Cys)	single nucleotide variant	Pathogenic	rs121913483	GRCh38	Chromosome 4, 1801841: 1801841

Cosmic variations for Keratosis, Seborrheic:

⁹

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location
1	COSM43920	TP53	skin,face,other,keratosis	c.680C>T	p.S227F	17:7674283-7674283
2	COSM44673	TP53	skin,face,other,keratosis	c.284C>T	p.S95F	17:7676085-7676085
3	COSM43861	TP53	skin,face,other,keratosis	c.502C>T	p.H168Y	17:7675110-7675110
4	COSM10722	TP53	skin,face,other,keratosis	c.853G>A	p.E285K	17:7673767-7673767
5	COSM44672	TP53	skin,face,other,keratosis	c.658T>A	p.Y220N	17:7674873-7674873
6	COSM484	HRAS	skin,chest,other,keratosis	c.35G>A	p.G12D	11:534288-534288

Sources

Expression for Keratosis, Seborrheic

Search GEO for disease gene expression data for Keratosis, Seborrheic.

Sources

Pathways for Keratosis, Seborrheic

Pathways related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Gastric cancer ³⁸ Show member pathways Breast cancer ³⁸ Hepatocellular carcinoma ³⁸	12.37	CDKN2A MTOR PIK3CA TGFB2
2	Glioma ³⁸ Show member pathways Endocrine resistance ³⁸ Melanoma ³⁸ Non-small cell lung cancer ³⁸ Signaling Pathways in Glioblastoma ¹	12.33	CDKN2A FGFR3 MTOR PIK3CA
3	Pathways in cancer ³⁸	12.28	CDKN2A FGFR3 MTOR PIK3CA TGFB2
4	G-protein signaling RAC1 in cellular process ²³ Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²³ RAC1 signaling pathway ¹	12.05	FGFR3 MTOR PIK3CA TGFB2
5	AKT Signaling Pathway ⁶⁸	11.81	FGFR3 MTOR PIK3CA
6	Immune response IFN gamma signaling pathway ²³ Show member pathways IFN-gamma pathway ¹	11.68	FGFR3 MTOR PIK3CA TGFB2
7	MicroRNAs in cancer ³⁸	11.5	CDKN2A FGFR3 MTOR PIK3CA TGFB2
8	Cellular senescence (KEGG) ³⁸	11.46	CDKN2A MTOR PIK3CA TGFB2
9	Central carbon metabolism in cancer ³⁸	11.25	FGFR3 MTOR PIK3CA
10	G-protein signaling_Cross-talk between Ras-family GTPases ²³	11	FGFR3 MTOR PIK3CA TGFB2
11	Extracellular vesicle-mediated signaling in recipient cells ¹	10.99	MTOR TGFB2
12	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities ¹	10.97	MTOR PIK3CA

Sources

GO Terms for Keratosis, Seborrheic

Cellular components related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:0005882	8.8	KRT10 KRT17 KRT5

Biological processes related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of protein kinase B signaling	GO:0051897	9.67	FGFR3 MTOR PIK3CA
2	cell cycle arrest	GO:0007050	9.61	CDKN2A MTOR TGFB2
3	cornification	GO:0070268	9.54	KRT10 KRT17 KRT5
4	hair follicle morphogenesis	GO:0031069	9.48	KRT17 TGFB2
5	positive regulation of T cell mediated cytotoxicity	GO:0001916	9.46	CD1A CD1E
6	negative regulation of macroautophagy	GO:0016242	9.4	MTOR PIK3CA
7	anoikis	GO:0043276	9.32	MTOR PIK3CA
8	somatic stem cell division	GO:0048103	9.26	CDKN2A TGFB2
9	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	GO:0048007	9.16	CD1A CD1E
10	heart valve morphogenesis	GO:0003179	8.96	MTOR TGFB2
11	antigen processing and presentation, endogenous lipid antigen via MHC class Ib	GO:0048006	8.62	CD1A CD1E

Molecular functions related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lipopeptide binding	GO:0071723	9.16	CD1A CD1E
2	endogenous lipid antigen binding	GO:0030883	8.96	CD1A CD1E
3	exogenous lipid antigen binding	GO:0030884	8.62	CD1A CD1E

Sources

Sources for Keratosis, Seborrheic

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Keratosis, Seborrheic (KERSEB)

Aliases & Classifications for Keratosis, Seborrheic

MalaCards integrated aliases for Keratosis, Seborrheic:

Characteristics:

OMIM:

HPO:

Classifications:

External Ids:

Summaries for Keratosis, Seborrheic

Related Diseases for Keratosis, Seborrheic

Diseases related to Keratosis, Seborrheic via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Keratosis, Seborrheic via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Keratosis, Seborrheic:

Symptoms & Phenotypes for Keratosis, Seborrheic

Human phenotypes related to Keratosis, Seborrheic:

Symptoms via clinical synopsis from OMIM:

Clinical features from OMIM:

GenomeRNAi Phenotypes related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Keratosis, Seborrheic:

Drugs & Therapeutics for Keratosis, Seborrheic

Drugs for Keratosis, Seborrheic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Cochrane evidence based reviews: keratosis, seborrheic

Genetic Tests for Keratosis, Seborrheic

Genetic tests related to Keratosis, Seborrheic:

Anatomical Context for Keratosis, Seborrheic

MalaCards organs/tissues related to Keratosis, Seborrheic:

Publications for Keratosis, Seborrheic

Articles related to Keratosis, Seborrheic:

Genes for Keratosis, Seborrheic

Genes related to Keratosis, Seborrheic (2 elite genes):

Variations for Keratosis, Seborrheic

UniProtKB/Swiss-Prot genetic disease variations for Keratosis, Seborrheic:

ClinVar genetic disease variations for Keratosis, Seborrheic:

Cosmic variations for Keratosis, Seborrheic:

Expression for Keratosis, Seborrheic

Pathways for Keratosis, Seborrheic

Pathways related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

GO Terms for Keratosis, Seborrheic

Cellular components related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

Biological processes related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

Molecular functions related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

Sources for Keratosis, Seborrheic