Keratosis, Seborrheic disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ Seborrheic keratosis is a benign (non cancerous) tumor found on the skin. Seborrheic keratoses are the most common benign tumor in older individuals. They usually appear as multiple small, flat or raised growths that range in color from white to black and are commonly found on the face, neck, chest, shoulders, and hands. They usually do not cause symptoms, but occasionally can itch and rub or catch on clothing, causing irritation. Scratching seborrheic keratoses or trying to pick them off the skin can result in a secondary infection. The cause of Seborrheic keratosis is not well understood; however, a combination of environmental factors, such as sun exposure and genetic factors may play a role.

MalaCards based summary: Keratosis, Seborrheic, also known as seborrheic keratosis, is related to inflamed seborrheic keratosis and clear cell acanthoma. An important gene associated with Keratosis, Seborrheic is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Endometrial cancer and Burn wound healing. The drugs Hydrogen peroxide and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and cervix, and related phenotypes are epidermal nevus and seborrheic keratosis

UniProtKB/Swiss-Prot: ⁷³ A common benign skin tumor. Seborrheic keratoses usually begin with the appearance of one or more sharply defined, light brown, flat macules. The lesions may be sparse or numerous. As they initially grow, they develop a velvety to finely verrucous surface, followed by an uneven warty surface with multiple plugged follicles and a dull or lackluster appearance.

OMIM®: ⁵⁷ Seborrheic keratoses are common benign epidermal lesion that can develop on any part of the body. (182000) (Updated 24-Oct-2022)

Wikipedia: ⁷⁵ A seborrheic keratosis is a non-cancerous (benign) skin tumour that originates from cells in the outer... more...

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Related Diseases for Keratosis, Seborrheic

Diseases related to Keratosis, Seborrheic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 373)

#	Related Disease	Score	Top Affiliating Genes
1	inflamed seborrheic keratosis	32.6	CD1E CD1A
2	clear cell acanthoma	32.2	KRT5 KRT10
3	melanoacanthoma	32.2	TYR MLANA FGFR3 DPH3
4	basal cell carcinoma	31.1	TYR TP53 MC1R KRT5 KRT10 CDKN2A
5	anogenital venereal wart	31.1	TP53 TMC8 CDKN2A
6	common wart	31.0	TP53 TMC8 TMC6
7	in situ carcinoma	31.0	TP53 PIK3CA KRT5 CDKN2A
8	nevus, epidermal	30.9	PIK3CA KRT10 FGFR3
9	skin benign neoplasm	30.9	TYR TP53 MLANA KRT5 FGFR3
10	papilloma	30.9	TP53 KRT5 KRT10 FGFR3 CDKN2A
11	eccrine acrospiroma	30.8	KRT5 KRT10
12	keratoacanthoma	30.8	TP53 PIK3CA KRT10 CD1A
13	dermatosis papulosa nigra	30.8	FGFR3 DPH3
14	epidermodysplasia verruciformis 1	30.7	TP53 TMC8 TMC6 CDKN2A
15	lichen planus	30.6	TP53 KRT10 CD1A
16	adenoid squamous cell carcinoma	30.5	TP53 KRT5
17	dowling-degos disease 1	30.5	TYR MITF KRT5 FGFR3
18	inverted transitional papilloma	30.4	KRT5 CDKN2A
19	verrucous carcinoma	30.4	TP53 PIK3CA KRT5 CDKN2A
20	sebaceous adenocarcinoma	30.4	TP53 MLANA KRT5 CDKN2A
21	skin squamous cell carcinoma	30.4	TP53 KRT5 KRT10 CDKN2A
22	cutaneous ganglioneuroma	30.4	PIK3CA MITF FOXN1 FGFR3
23	pigmented basal cell carcinoma	30.4	MLANA MITF
24	porokeratosis	30.3	TP53 TMC8 KRT10 FGFR3
25	actinic keratosis	30.2	TP53 TMC8 MLANA MC1R KRT10 CDKN2A
26	lichen nitidus	30.2	CD1E CD1B CD1A
27	granuloma annulare	30.2	CD1E CD1B CD1A
28	seborrheic dermatitis	30.2	CD1E CD1B CD1A
29	folliculitis	30.2	CD1E CD1B CD1A
30	breast adenocarcinoma	30.1	TP53 PIK3CA KRT5 CDKN2A
31	skin melanoma	30.1	TYR TP53 PIK3CA MLANA MITF MC1R
32	leprosy 3	30.1	CD1E CD1B CD1A
33	keratosis	30.1	TP53 TMC8 PIK3CA MC1R KRT5 KRT10
34	skin carcinoma	30.0	TYR TP53 TMC8 TMC6 MLANA MITF
35	melanoma in congenital melanocytic nevus	29.8	TYR TP53 MLANA MITF MC1R CDKN2A
36	skin disease	29.2	TYR TP53 PIK3CA MLANA MITF MC1R
37	acanthoma	29.0	TYR TP53 TMC8 TMC6 PIK3CA MLANA
38	vulvar seborrheic keratosis	11.6
39	inverted follicular keratosis	11.2
40	basal cell carcinoma 1	10.8
41	melanoma	10.7
42	squamous cell carcinoma	10.6
43	bowen's disease	10.5
44	muir-torre syndrome	10.4
45	anal canal paget's disease	10.4	MLANA CDKN2A
46	vulval paget's disease	10.4	MLANA CDKN2A
47	ciliary body cancer	10.4	TYR MLANA
48	vaginal carcinosarcoma	10.4	TP53 PIK3CA
49	endometrial squamous cell carcinoma	10.4	TP53 CDKN2A
50	diffuse meningeal melanocytosis	10.3	TYR MLANA

Comorbidity relations with Keratosis, Seborrheic via Phenotypic Disease Network (PDN):

Hypertension, Essential

Keratosis

Graphical network of the top 20 diseases related to Keratosis, Seborrheic:

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Symptoms & Phenotypes for Keratosis, Seborrheic

Human phenotypes related to Keratosis, Seborrheic:

³⁰

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	epidermal nevus ³⁰			HP:0010816
2	seborrheic keratosis ³⁰			HP:0031287

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 24-Oct-2022)

Skin:
seborrheic keratoses
congenital seborrheic verrucae

Clinical features from OMIM®:

182000 (Updated 24-Oct-2022)

GenomeRNAi Phenotypes related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.14	CCHCR1 CD1A CD1B CD1E CDKN2A DPH3
2	no effect	GR00402-S-2	10.14	CCHCR1 CD1A CD1E CDKN2A DPH3 FGFR3

MGI Mouse Phenotypes related to Keratosis, Seborrheic:

⁴⁵ (show all 11)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.24	CDKN2A DPH3 FGFR3 FOXN1 GDA KRT10
2	immune system	MP:0005387	10.1	CCHCR1 CDKN2A FGFR3 FOXN1 GDA KRT10
3	neoplasm	MP:0002006	10.08	CDKN2A FGFR3 FOXN1 KRT10 MC1R PIK3CA
4	no phenotypic analysis	MP:0003012	10.06	CDKN2A FGFR3 MC1R MITF MLANA PIK3CA
5	pigmentation	MP:0001186	10.04	CDKN2A FOXN1 MC1R MITF MLANA TP53
6	limbs/digits/tail	MP:0005371	10.03	FGFR3 KRT10 KRT5 MC1R MITF TGFB2
7	hearing/vestibular/ear	MP:0005377	10.01	FGFR3 FOXN1 KRT10 MC1R MITF TGFB2
8	craniofacial	MP:0005382	9.92	FGFR3 KRT10 KRT5 MC1R MITF TGFB2
9	reproductive system	MP:0005389	9.85	CDKN2A FGFR3 FOXN1 MITF PIK3CA TGFB2
10	skeleton	MP:0005390	9.65	CDKN2A FGFR3 FOXN1 GDA MITF PIK3CA
11	integument	MP:0010771	9.47	CCHCR1 CDKN2A FGFR3 FOXN1 KRT10 KRT5

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Drugs & Therapeutics for Keratosis, Seborrheic

Drugs for Keratosis, Seborrheic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Hydrogen peroxide

Approved, Vet_approved

Phase 4

7722-84-1

784

2

Pharmaceutical Solutions

Phase 4

3

Petrolatum

Approved, Investigational

8009-03-8

4

Fusidic acid

Approved, Investigational

6990-06-3

3000226

5

Racepinephrine

Approved, Vet_approved

51-43-4, 329-65-7

838 5816

Synonyms:

(−)-(R)-epinephrine

(-)-(R)-Epinephrine

(-)-3,4-Dihydroxy-a-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-a-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol

(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-alpha-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]BENZYL ALCOHOL(-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]-BENZYL ALCOHOL

(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol

(−)-3,4-dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-α-((methylamino)methyl)benzyl alcohol

(−)-adrenaline

(-)-Adrenaline

(-)-Epinephrine

(+-)-Adrenaline

(+-)-Epinephrine

(R)-(-)-Adnephrine

(R)-(−)-adrenaline

(R)-(-)-Adrenaline

(R)-(-)-Epinephrine

(R)-(-)-Epirenamine

(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

(R)-Adrenaline

(R)-Epinephrine

2-(Methylamino)-1-(3,4-dihydroxyphenyl)ethanol

4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

4-[(1R)-1-HYDROXY-2-METHYLAMINOETHYL]BENZENE-1,2-DIOL

4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]BENZENE-1,2-DIOL

4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]PYROCATECHOL

Acetate, epinephrine

Adnephrine

ADREN CO

ADRENACLICK

Adrenal

Adrenalin

Adrenaline

Adrénaline

Adrenaline acid tartrate

Adrenaline bitartrate

Adrenaline hydrochloride

Adrenaline hydrochloride, racemic mixture

Adrenaline, racemic

Adrenaline, racemic mixture

adrenaline|epinephrine

Adrenine

Adrin

Allergan brand OF adrenaline hydrochloride

ANA-GUARD

Ana-kit

ANAPEN

ANAPHYLACTIC SHOCK DRUG KIT

ASMA-VYDRIN

ASTHMAHALER

Auvi-Q

Bird brand OF racepinefrine hydrochloride

Bosmin

Bronkaid mist

BROVON

Chelafrin

DL-Adrenaline

EMERADE

EPI E Z PEN JR

Epifrin

Epiglaufrin

Epinefrin

Epinefrina

Epinephran

Epinephrin

Epinephrine

Epinephrine acetate

Epinephrine bitartrate

EPINEPHRINE HCL

Epinephrine hydrochloride

Epinephrine hydrochloride, racemic mixture

Epinephrine hydrogen tartrate

Epinephrine racemic

Epinephrine, racemic

Epinephrine, racemic mixture

Epinephrinum

Epipen

EPIPEN E Z PEN

Epipen JR

EPIPEN JR.

Epirenan

Epitrate

Eppy

Exadrin

Glauposine

GPPE INH SOLN

Hemisine

Hemostasin

Hemostatin

Hydrochloride, racepinephrine

Hypernephrin

Isoptoepinal

JEXT

L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

L-Adrenaline

L-DETHYLAMINOETHANOLCATECHOL

L-Epinephrine

L-Epirenamine

Levoepinephrine

LEVO-METHYLAMINOETHANOLCATECHOL

Levorenen

Levorenin

Levorenine

Levoreninum

L-Methylaminoethanolcatechol

Lyodrin

Lyophrin

Medihaler-epi

Methylarterenol

Micronefrin

Micronephrine

Mixture adrenaline, racemic

Mixture epinephrine, racemic

Mucidrina

Nephridine

Nieraline

NSC-62786

Paranephrin

Primatene

Primatene mist

R-(-)-Epinephrine

Racemic adrenaline

Racemic epinephrine

Racemic mixture adrenaline

Racemic mixture epinephrine

Racepinefrina

Racepinefrine

Racepinefrinum

Racepinephrine

Racepinephrine hydrochloride

Renaglandin

Renaleptine

Renalina

Renoform

Renostypticin

Renostyptin

RIDDOBRON

RIDDOFAN

RYBARVIN

Scurenaline

Simplene

SOLN MADE TO RYBARVIN FOR

Styptirenal

Supracapsulin

Supranephrane

Suprarenaline

Suprarenin

Surrenine

Sus-phrine

SUS-PHRINE SULFITE FREE

SUS-PHRINE SULFITE-FREE

SYMJEPI

Takamina

TWINJECT

TWINJECT 0.15

TWINJECT 0.3

Vaponefrin

Vasoconstrictine

Vasotonin

6

Lidocaine

Approved, Vet_approved

137-58-6

3676

7

Chlorhexidine

Approved, Vet_approved

55-56-1

2713 9552079

8

Anti-Infective Agents

9

Anti-Bacterial Agents

10

Emollients

11

Anesthetics

12

Epinephryl borate

13

Dermatologic Agents

14

Chlorhexidine gluconate

Interventional clinical trials:

(show all 19)

#	Name	Status	NCT ID	Phase	Drugs
1	An Open-Label Study Assessing Subject Satisfaction With A-101 Hydrogen Peroxide Topical Solution, 40% (w/w) Treatment for Seborrheic Keratoses of the Face, Neck, and Decolletage	Completed	NCT03487588	Phase 4	A-101 Topical Solution
2	An Open-Label Study of the Safety of A-101 Solution 40% in Subjects With Seborrheic Keratosis on the Trunk, Extremities and Face.	Completed	NCT02667288	Phase 3	A-101 Solution
3	A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Safety and Effectiveness of A-101 Solution 40% in Subjects With Seborrheic Keratosis on the Trunk, Extremities and Face.	Completed	NCT02667236	Phase 3	A-101 Solution
4	A Randomized, Double-Blind, Vehicle-Controlled, PArallel Group Study of the Safety and Effectiveness of A-101 Solution 40% in Subjects With Seborrheic Keratosis on the Trunk, Extremities and Face.	Completed	NCT02667275	Phase 3	A-101 Solution
5	A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Dose-Response Profile of A-101 Topical Solution in Subjects With Seborrheic Keratosis of the Face	Completed	NCT02260180	Phase 2	A-101
6	A Randomized, Double-Blind, Vehicle-Controlled, Within-Subject, Comparison Study of the Safety, Tolerability, And Effectiveness of A-101 Topical Solution in Subjects With Seborrheic Keratosis	Completed	NCT01986920	Phase 1, Phase 2	A-101 25%;A-101 32.5%;A-101 40%;A-101 Vehicle
7	A Randomized, Double-Blind, Vehicle Controlled, Parallel Group Study of the Dose-Response Profile of A-101 Topical Solution in Subjects With Seborrheic Keratosis.	Completed	NCT02160626	Phase 2	A-101 Vehicle;A-101 (40) Topical Solution;A-101 (32.5) Topical Solution
8	A Phase 2 Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Safety and Effectiveness of A-101(Hydrogen Peroxide) Topical Solution in Subjects With Seborrheic Keratosis Lesions on the Trunk, Extremities, and Face	Completed	NCT03148691	Phase 2	A-101
9	A Phase 2a, Multi-Centre, Open-Label Study to Evaluate the Safety and Efficacy of PEP005(Ingenol Mebutate) Gel, 0.05%, in Patients With Seborrhoeic Keratosis on Non-head Locations	Completed	NCT01214564	Phase 2	PEP005 (ingenol mebutate) Gel
10	Open Label Adaptive Design Study to Explore the Safety and Efficacy of Multiple Treatment Regimens With the Akt Inhibitor SM-020 in 1.0% and 0.1% Gel Formulations in Subjects With Seborrheic Keratosis	Recruiting	NCT05136144	Phase 2	SM-020
11	Fast Track Diagnosis of Skin Tumours by Four Different Advanced Imaging Technologies - a Clinical Study	Unknown status	NCT04229277
12	Evaluation of Nano-Pulse Stimulation (NPS) in Patients With Seborrheic Keratosis	Completed	NCT03846531
13	Optical Biopsy of Human Skin in Conjunction With Laser Treatment	Completed	NCT00540566
14	Effectiveness of Sodium Fusidate Ointment Compared to Petrolatum for Wound Healing Following Cauterization: A Double-Blind Randomized Controlled Trial	Completed	NCT05353374		Sodium Fusidate 2 % Topical Ointment;Petrolatum ointment
15	Is Cryosurgery or Curettage More Effective at Treating Seborrheic Keratoses?	Completed	NCT01159860
16	Efficacy of a 585 nm Pulsed Dye Laser (PDL) for the Treatment of Dermatosis Papulosa Nigra, and Compare it to Therapy With Curettage and Electrodesiccation.	Completed	NCT00710203
17	Prospective, Open-Label, Multi-Center, Non-Significant Risk Study of Nano-Pulse Stimulation™ (NPS™) Technology in Healthy Adults With Seborrheic Keratosis	Active, not recruiting	NCT04249115
18	Comparative Study of Electrical Impedance Spectroscopy (EIS) Models Against Verified Dermatological Diagnostic Data	Suspended	NCT04688749
19	Comparing the Efficacy and Risk of Adverse Events of Electrocautery Versus 532 nm Qswitched Neodymium-doped Yttrium Aluminium Garnet Laser for the Treatment of Flat Seborrheic Keratoses: A Randomized Control Trial	Withdrawn	NCT02366559

Search NIH Clinical Center for Keratosis, Seborrheic

Cochrane evidence based reviews: keratosis, seborrheic

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Genetic Tests for Keratosis, Seborrheic

Genetic tests related to Keratosis, Seborrheic:

#	Genetic test	Affiliating Genes
1	Seborrheic Keratosis ²⁸	PIK3CA

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Anatomical Context for Keratosis, Seborrheic

Organs/tissues related to Keratosis, Seborrheic:

MalaCards : Skin, Liver, Cervix, Breast, Smooth Muscle, Eye, T Cells

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Publications for Keratosis, Seborrheic

Articles related to Keratosis, Seborrheic:

(show top 50) (show all 1020)

#	Title	Authors	PMID	Year
1	Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans. ⁵³ ⁶² ⁵⁷ ⁵	Logie A...Radvanyi F	15772091	2005
2	Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern. ⁵³ ⁵⁷ ⁵	Hafner C...Real FX	17673550	2007
3	Somatic PIK3CA Mutations in Sporadic Cerebral Cavernous Malformations. ⁵	Peyre M...Kalamarides M	34496175	2021
4	Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity. ⁵	Van Keymeulen A...Blanpain C	26266985	2015
5	PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours. ⁵	Koren S...Bentires-Alj M	26266975	2015
6	Somatic gain-of-function mutations in PIK3CA in patients with macrodactyly. ⁵	Rios JJ...Ezaki M	23100325	2013
7	Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome. ⁵	Kurek KC...Warman ML	22658544	2012
8	De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly. ⁵	Lee JH...Gleeson JG	22729223	2012
9	De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes. ⁵	Riviere JB...Dobyns WB	22729224	2012
10	Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA. ⁵	Lindhurst MJ...Semple RK	22729222	2012
11	An epidermal nevus syndrome with cerebral involvement caused by a mosaic FGFR3 mutation. ⁵	Garcia-Vargas A...Happle R	18642369	2008
12	Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi. ⁵	Hafner C...Hartmann A	16841094	2006
13	PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. ⁵	Lee JW...Lee SH	15608678	2005
14	Mutation of the PIK3CA gene in ovarian and breast cancer. ⁵	Campbell IG...Phillips WA	15520168	2004
15	High frequency of mutations of the PIK3CA gene in human cancers. ⁵	Samuels Y...Velculescu VE	15016963	2004
16	Somatic and germline mosaicism for a R248C missense mutation in FGFR3, resulting in a skeletal dysplasia distinct from thanatophoric dysplasia. ⁵	Hyland VJ...Glass IA	12833394	2003
17	Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14). ⁵	Intini D...Neri A	11529856	2001
18	Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. ⁵	Cappellen D...Radvanyi F	10471491	1999
19	Prenatal diagnosis of thanatophoric dysplasia by mutational analysis of the fibroblast growth factor receptor 3 gene and a proposed correction of previously published PCR results. ⁵	Sawai H...Koyama K	10073901	1999
20	Molecular, radiologic, and histopathologic correlations in thanatophoric dysplasia. ⁵	Wilcox WR...Rimoin DL	9677066	1998
21	Japanese cases of type 1 thanatophoric dysplasia exclusively carry a C to T transition at nucleotide 742 of the fibroblast growth factor receptor 3 gene. ⁵	Pokharel RK...Matsuo M	8858131	1996
22	Another mutation that results in the substitution of an unpaired cysteine residue in the extracellular domain of FGFR3 in thanatophoric dysplasia type I. ⁵	Tavormina PL...Wasmuth JJ	8589699	1995
23	Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3. ⁵	Tavormina PL...Wasmuth JJ	7773297	1995
24	Familial congenital multiple seborrheic verrucae. ⁵⁷	Bedi TR	143912	1977
25	FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes. ⁵³ ⁶²	Hafner C...Vogt T	20420824	2010
26	Fibroblast growth factor receptor 3 mutations in epidermal nevi and associated low grade bladder tumors. ⁵³ ⁶²	Hernandez S...Real FX	17255960	2007
27	Dysregulated expression of transforming growth factor beta and its type-I and type-II receptors in basal-cell carcinoma. ⁵³ ⁶²	Furue M...Tamaki K	9178800	1997
28	Cutaneous Ganglioneuromas With Overlying Epidermal Hyperplasia: A Case Series Presentation and Proposal of Potential Etiopathogenesis. ⁶²	Zuraski CR...Moshiri AS	35925148	2022
29	Demodicosis as a Skin Complication in Organ Transplant Recipients: A Case Series. ⁶²	Marquardt-Feszler A...Imko-Walczuk B	36206203	2022
30	Diagnostic accuracy of dermoscopy for 934 basal cell carcinomas: A single-center retrospective study. ⁶²	Yuki A...Takenouchi T	36229917	2022
31	Update of Pathophysiology and Treatment Options of Seborrheic Keratosis. ⁶²	Gorai S...Goldust M	36226729	2022
32	Clonal-pattern Seborrheic Keratosis: Risk of Recurrence and Progression to Carcinoma. ⁶²	Goldsmith JF...Tahan SR	36221316	2022
33	A Case of Seborrheic Keratosis on the Volar Side of the Fingers after Skin Graft. ⁶²	Park HJ...Park CJ	36198635	2022
34	Study on the correlation of high expression level of HuD with seborrheic keratosis and skin aging. ⁶²	Chen J...Li H	36065721	2022
35	New diagnostic approach in seborrheic keratosis: Cryosign. ⁶²	Yurekli A...Akay BN	36136098	2022
36	Utility of 30% hydrogen peroxide in the treatment of seborrheic keratosis. ⁶²	Suvarna P...Kayarkatte MN	35094378	2022
37	Verrucous Melanoma of the Scalp Initially Misdiagnosed as Seborrheic Keratosis. ⁶²	Kerouach A...Chiheb S	36249606	2022
38	Facial skin characteristics and concerns in Indonesia: A cross-sectional observational study. ⁶²	Du Y...Joshi MK	35785442	2022
39	Adipophilin expression in skin lesions with clear cell histology. ⁶²	Li FZ...Fang S	33952590	2022
40	In vivo evaluation of facial papule dermatoses with reflectance confocal microscopy in children. ⁶²	Chen L...Li Q	35726961	2022
41	Three-dimensional representation of triple spectral line imaging data as an option for noncontact skin diagnostics. ⁶²	Osina I...Berzina A	36114603	2022
42	Dermatopathology of Malignant Melanoma in the Era of Artificial Intelligence: A Single Institutional Experience. ⁶²	Cazzato G...Vacca A	36010322	2022
43	Human papillomavirus genotype distribution of genital keratotic lesions. ⁶²	Seong SH...Jang MS	35545860	2022
44	Ungual seborrheic keratosis with longitudinal melanonychia: A case report. ⁶²	Kameda E...Matsue H	35429058	2022
45	Evaluation of a Deep Learning Approach to Differentiate Bowen's Disease and Seborrheic Keratosis. ⁶²	Jansen P...Griewank KG	35884578	2022
46	Reconstruction of the Defect at Temporal Hairline by a Scalp Keystone Island Flap: Clinical Experience on 14 Cases. ⁶²	Tang W...Bi H	35119399	2022
47	Classification of skin cancer using convolutional neural networks analysis of Raman spectra. ⁶²	Bratchenko IA...Zakharov VP	35349907	2022
48	[Occult basal cell carcinoma intermingling with seborrheic keratosis of the eyelid : A clinicopathological case report]. ⁶²	Nuessle S...Auw-Haedrich C	34043084	2022
49	Effectiveness of a cosmetic device containing a combination of alpha- and beta-hydroxy acids, urea, and thuja for the treatment of seborrheic keratoses. ⁶²	Campione E...Bianchi L	34263966	2022
50	2940-nm erbium:YAG laser versus 980-nm diode laser in the treatment of multiple seborrheic keratoses: A prospective comparative randomized study. ⁶²	Osman MA	35579410	2022

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Genes for Keratosis, Seborrheic

Genes related to Keratosis, Seborrheic (2 elite genes):

(show all 25)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1314.45	Molecular basis known ⁵⁷ Pathogenic ⁵ Causative variation ⁷³ Genetic Tests ²⁸ DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)	15016963 15520168 15608678 (more) 17673550 22658544 22729222 22729223 22729224 23100325 26266975 26266985 34496175
2	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	724.52	Pathogenic ⁵ Causative variation ⁷³ DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders (show sections)	7773297 8589699 8858131 (more) 9677066 10073901 10471491 11529856 12833394 15772091 16841094 18642369 17585316 16778799 17392824 17673550 20420824 18728396 17255960 17172848 17568799
3	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	6.94	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9178800
4	MLANA	Melan-A	Protein Coding	6.64	DISEASES inferred ¹⁴
5	TMC8	Transmembrane Channel Like 8	Protein Coding	5.87	DISEASES inferred ¹⁴
6	KRT10	Keratin 10	Protein Coding	5.71	DISEASES inferred ¹⁴
7	GDA	Guanine Deaminase	Protein Coding	5.59	DISEASES inferred ¹⁴
8	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	5.49	DISEASES inferred ¹⁴
9	DPH3	Diphthamide Biosynthesis 3	Protein Coding	5.38	DISEASES inferred ¹⁴
10	MC1R	Melanocortin 1 Receptor	Protein Coding	5.32	DISEASES inferred ¹⁴
11	TP53	Tumor Protein P53	Protein Coding	5.32	DISEASES inferred ¹⁴
12	TYR	Tyrosinase	Protein Coding	5.31	DISEASES inferred ¹⁴
13	TMC6	Transmembrane Channel Like 6	Protein Coding	5.28	DISEASES inferred ¹⁴
14	CD1B	CD1b Molecule	Protein Coding	5.25	DISEASES inferred ¹⁴
15	FOXN1	Forkhead Box N1	Protein Coding	5.24	DISEASES inferred ¹⁴
16	CD1E	CD1e Molecule	Protein Coding	5.2	DISEASES inferred ¹⁴
17	CD1A	CD1a Molecule	Protein Coding	5.17	DISEASES inferred ¹⁴
18	KRT5	Keratin 5	Protein Coding	5.16	DISEASES inferred ¹⁴
19	MITF	Melanocyte Inducing Transcription Factor	Protein Coding	5.11	DISEASES inferred ¹⁴
20	CCHCR1	Coiled-Coil Alpha-Helical Rod Protein 1	Protein Coding	5.02	DISEASES inferred ¹⁴
21	CD1C	CD1c Molecule	Protein Coding	5	DISEASES inferred ¹⁴
22	KRT7	Keratin 7	Protein Coding	5	DISEASES inferred ¹⁴
23	KRT17	Keratin 17	Protein Coding	4.97	DISEASES inferred ¹⁴
24	IVL	Involucrin	Protein Coding	4.9	DISEASES inferred ¹⁴
25	CD1D	CD1d Molecule	Protein Coding	4.89	DISEASES inferred ¹⁴

Sources

Variations for Keratosis, Seborrheic

ClinVar genetic disease variations for Keratosis, Seborrheic:

IMPROVED

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	PIK3CA	NM_006218.4(PIK3CA):c.3140A>G (p.His1047Arg)	SNV	Pathogenic	13652	rs121913279	GRCh37: 3:178952085-178952085 GRCh38: 3:179234297-179234297
2	PIK3CA	NM_006218.4(PIK3CA):c.1633G>A (p.Glu545Lys)	SNV	Pathogenic	13655	rs104886003	GRCh37: 3:178936091-178936091 GRCh38: 3:179218303-179218303
3	FGFR3	NM_000142.5(FGFR3):c.742C>T (p.Arg248Cys)	SNV	Pathogenic	16332	rs121913482	GRCh37: 4:1803564-1803564 GRCh38: 4:1801837-1801837
4	FGFR3	NM_000142.5(FGFR3):c.746C>G (p.Ser249Cys)	SNV	Pathogenic	16339	rs121913483	GRCh37: 4:1803568-1803568 GRCh38: 4:1801841-1801841
5	PIK3CA	NM_006218.4(PIK3CA):c.3139C>T (p.His1047Tyr)	SNV	Pathogenic	39705	rs121913281	GRCh37: 3:178952084-178952084 GRCh38: 3:179234296-179234296
6	PIK3CA	NM_006218.4(PIK3CA):c.436G>A (p.Val146Ile)	SNV	Uncertain Significance	526641	rs755969956	GRCh37: 3:178917561-178917561 GRCh38: 3:179199773-179199773
7	PIK3CA	NM_006218.4(PIK3CA):c.1130C>G (p.Pro377Arg)	SNV	Uncertain Significance	403909	rs113613074	GRCh37: 3:178922361-178922361 GRCh38: 3:179204573-179204573

UniProtKB/Swiss-Prot genetic disease variations for Keratosis, Seborrheic:

⁷³ (show all 11)

#	Symbol	AA change	Variation ID	SNP ID
1	FGFR3	p.Arg248Cys	VAR_004148	rs121913482
2	FGFR3	p.Ser249Cys	VAR_004149	rs121913483
3	FGFR3	p.Gly370Cys	VAR_004151	rs121913479
4	FGFR3	p.Ser371Cys	VAR_004152	rs121913484
5	FGFR3	p.Tyr373Cys	VAR_004153	rs121913485
6	FGFR3	p.Lys650Glu	VAR_004160	rs78311289
7	FGFR3	p.Lys650Met	VAR_004161	rs121913105
8	PIK3CA	p.Glu542Lys	VAR_026173	rs121913273
9	PIK3CA	p.Glu545Gly	VAR_026177	rs121913274
10	PIK3CA	p.Glu545Lys	VAR_026178	rs104886003
11	PIK3CA	p.His1047Arg	VAR_026192	rs121913279

Cosmic variations for Keratosis, Seborrheic:

⁸ (show top 50) (show all 88)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM142560375	TP53	skin,face,other,keratosis	c.736G>A	p.E246K	17:7673767-7673767	10
2	COSM143664176	TP53	skin,face,other,keratosis	c.167C>T	p.S56F	17:7676085-7676085	10
3	COSM88264321	TP53	skin,face,other,keratosis	c.284C>T	p.S95F	17:7676085-7676085	10
4	COSM87898458	TP53	skin,face,other,keratosis	c.853G>A	p.E285K	17:7673767-7673767	10
5	COSM144013535	TP53	skin,face,other,keratosis	c.647C>T	p.S216F	17:7674283-7674283	10
6	COSM144345273	TP53	skin,face,other,keratosis	c.385C>T	p.H129Y	17:7675110-7675110	10
7	COSM143370962	TP53	skin,face,other,keratosis	c.736G>A	p.E246K	17:7673767-7673767	10
8	COSM143156898	TP53	skin,face,other,keratosis	c.376G>A	p.E126K	17:7673767-7673767	10
9	COSM112271356	TP53	skin,face,other,keratosis	c.658T>A	p.Y220N	17:7674873-7674873	10
10	COSM111776633	TP53	skin,face,other,keratosis	c.658T>A	p.Y220N	17:7674873-7674873	10
11	COSM111802255	TP53	skin,face,other,keratosis	c.502C>T	p.H168Y	17:7675110-7675110	10
12	COSM111758655	TP53	skin,face,other,keratosis	c.853G>A	p.E285K	17:7673767-7673767	10
13	COSM121895107	TP53	skin,face,other,keratosis	c.262T>A	p.Y88N	17:7674873-7674873	10
14	COSM142605302	TP53	skin,face,other,keratosis	c.385C>T	p.H129Y	17:7675110-7675110	10
15	COSM112296759	TP53	skin,face,other,keratosis	c.502C>T	p.H168Y	17:7675110-7675110	10
16	COSM144029046	TP53	skin,face,other,keratosis	c.625T>A	p.Y209N	17:7674873-7674873	10
17	COSM105673018	TP53	skin,face,other,keratosis	c.502C>T	p.H168Y	17:7675110-7675110	10
18	COSM144984225	TP53	skin,face,other,keratosis	c.167C>T	p.S56F	17:7676085-7676085	10
19	COSM144325001	TP53	skin,face,other,keratosis	c.541T>A	p.Y181N	17:7674873-7674873	10
20	COSM105947517	TP53	skin,face,other,keratosis	c.284C>T	p.S95F	17:7676085-7676085	10
21	COSM145017841	TP53	skin,face,other,keratosis	c.563C>T	p.S188F	17:7674283-7674283	10
22	COSM144013457	TP53	skin,face,other,keratosis	c.820G>A	p.E274K	17:7673767-7673767	10
23	COSM106053265	TP53	skin,face,other,keratosis	c.853G>A	p.E285K	17:7673767-7673767	10
24	COSM93482742	TP53	skin,face,other,keratosis	c.284C>T	p.S95F	17:7676085-7676085	10
25	COSM87898544	TP53	skin,face,other,keratosis	c.680C>T	p.S227F	17:7674283-7674283	10
26	COSM144670223	TP53	skin,face,other,keratosis	c.541T>A	p.Y181N	17:7674873-7674873	10
27	COSM105639626	TP53	skin,face,other,keratosis	c.658T>A	p.Y220N	17:7674873-7674873	10
28	COSM106070054	TP53	skin,face,other,keratosis	c.658T>A	p.Y220N	17:7674873-7674873	10
29	COSM145316791	TP53	skin,face,other,keratosis	c.167C>T	p.S56F	17:7676085-7676085	10
30	COSM142577206	TP53	skin,face,other,keratosis	c.541T>A	p.Y181N	17:7674873-7674873	10
31	COSM144100850	TP53	skin,face,other,keratosis	c.181T>A	p.Y61N	17:7674873-7674873	10
32	COSM145057476	TP53	skin,face,other,keratosis	c.385C>T	p.H129Y	17:7675110-7675110	10
33	COSM122288472	TP53	skin,face,other,keratosis	c.262T>A	p.Y88N	17:7674873-7674873	10
34	COSM122314636	TP53	skin,face,other,keratosis	c.106C>T	p.H36Y	17:7675110-7675110	10
35	COSM142850810	TP53	skin,face,other,keratosis	c.658T>A	p.Y220N	17:7674873-7674873	10
36	COSM121876085	TP53	skin,face,other,keratosis	c.457G>A	p.E153K	17:7673767-7673767	10
37	COSM144696180	TP53	skin,face,other,keratosis	c.385C>T	p.H129Y	17:7675110-7675110	10
38	COSM122734253	TP53	skin,face,other,keratosis	c.457G>A	p.E153K	17:7673767-7673767	10
39	COSM142560436	TP53	skin,face,other,keratosis	c.563C>T	p.S188F	17:7674283-7674283	10
40	COSM143959507	TP53	skin,face,other,keratosis	c.181T>A	p.Y61N	17:7674873-7674873	10
41	COSM106095670	TP53	skin,face,other,keratosis	c.502C>T	p.H168Y	17:7675110-7675110	10
42	COSM144651221	TP53	skin,face,other,keratosis	c.736G>A	p.E246K	17:7673767-7673767	10
43	COSM112253698	TP53	skin,face,other,keratosis	c.853G>A	p.E285K	17:7673767-7673767	10
44	COSM93201428	TP53	skin,face,other,keratosis	c.658T>A	p.Y220N	17:7674873-7674873	10
45	COSM143371041	TP53	skin,face,other,keratosis	c.563C>T	p.S188F	17:7674283-7674283	10
46	COSM143171478	TP53	skin,face,other,keratosis	c.181T>A	p.Y61N	17:7674873-7674873	10
47	COSM87949256	TP53	skin,face,other,keratosis	c.502C>T	p.H168Y	17:7675110-7675110	10
48	COSM143943874	TP53	skin,face,other,keratosis	c.376G>A	p.E126K	17:7673767-7673767	10
49	COSM112056954	TP53	skin,face,other,keratosis	c.284C>T	p.S95F	17:7676085-7676085	10
50	COSM145017758	TP53	skin,face,other,keratosis	c.736G>A	p.E246K	17:7673767-7673767	10

Sources

Expression for Keratosis, Seborrheic

Search GEO for disease gene expression data for Keratosis, Seborrheic.

Sources

Pathways for Keratosis, Seborrheic

Pathways related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.25	TP53 TGFB2 PIK3CA MITF FGFR3 CDKN2A
2	Burn wound healing ⁷⁴	11.46	TP53 TGFB2 FGFR3
3	Prader-Willi and Angelman syndrome ⁷⁴	11.33	TYR TP53 CDKN2A
4	Regulation of retinoblastoma protein ⁶¹	11.25	TGFB2 MITF CDKN2A
5	Head and neck squamous cell carcinoma ⁷⁴	11.12	TP53 PIK3CA FGFR3 CDKN2A
6	Bladder cancer ⁷⁴	11.03	TP53 FGFR3 CDKN2A
7	GPR143 in melanocytes and retinal pigment epithelium cells ⁷⁴	10.37	TYR MLANA MITF MC1R

Sources

GO Terms for Keratosis, Seborrheic

Cellular components related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005887	9.55	TMC8 TMC6 MLANA MC1R FGFR3 CD1E
2	plasma membrane	GO:0005886	9.55	TMC6 MLANA MC1R FGFR3 CD1E CD1A

Biological processes related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	pigmentation	GO:0043473	9.65	TYR MITF MC1R
2	positive regulation of T cell mediated cytotoxicity	GO:0001916	9.63	CD1E CD1B CD1A
3	T cell lineage commitment	GO:0002360	9.62	TP53 FOXN1
4	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	GO:0048007	9.43	CD1E CD1B CD1A
5	antigen processing and presentation, endogenous lipid antigen via MHC class Ib	GO:0048006	9.1	CD1E CD1B CD1A

Molecular functions related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lipopeptide binding	GO:0071723	9.63	CD1E CD1B CD1A
2	exogenous lipid antigen binding	GO:0030884	9.43	CD1E CD1B CD1A
3	endogenous lipid antigen binding	GO:0030883	9.1	CD1E CD1B CD1A

Sources

Sources for Keratosis, Seborrheic

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 24-Oct-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

KERSEB MCID: KRT071 MIFTS: 57	Keratosis, Seborrheic (KERSEB) Categories: Cancer diseases, Genetic diseases, Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

Keratosis, Seborrheic (KERSEB)

Aliases & Classifications for Keratosis, Seborrheic

MalaCards integrated aliases for Keratosis, Seborrheic:

Characteristics:

Inheritance:

Classifications:

External Ids:

Summaries for Keratosis, Seborrheic

Related Diseases for Keratosis, Seborrheic

Diseases related to Keratosis, Seborrheic via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Keratosis, Seborrheic via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Keratosis, Seborrheic:

Symptoms & Phenotypes for Keratosis, Seborrheic

Human phenotypes related to Keratosis, Seborrheic:

Symptoms via clinical synopsis from OMIM®:

Clinical features from OMIM®:

GenomeRNAi Phenotypes related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Keratosis, Seborrheic:

Drugs & Therapeutics for Keratosis, Seborrheic

Drugs for Keratosis, Seborrheic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Cochrane evidence based reviews: keratosis, seborrheic

Genetic Tests for Keratosis, Seborrheic

Genetic tests related to Keratosis, Seborrheic:

Anatomical Context for Keratosis, Seborrheic

Organs/tissues related to Keratosis, Seborrheic:

Publications for Keratosis, Seborrheic

Articles related to Keratosis, Seborrheic:

Genes for Keratosis, Seborrheic

Genes related to Keratosis, Seborrheic (2 elite genes):

Variations for Keratosis, Seborrheic

ClinVar genetic disease variations for Keratosis, Seborrheic:

UniProtKB/Swiss-Prot genetic disease variations for Keratosis, Seborrheic:

Cosmic variations for Keratosis, Seborrheic:

Expression for Keratosis, Seborrheic

Pathways for Keratosis, Seborrheic

Pathways related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

GO Terms for Keratosis, Seborrheic

Cellular components related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

Biological processes related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

Molecular functions related to Keratosis, Seborrheic according to GeneCards Suite gene sharing:

Sources for Keratosis, Seborrheic