MCID: KSH001
MIFTS: 37

Keshan Disease

Categories: Cardiovascular diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Keshan Disease

MalaCards integrated aliases for Keshan Disease:

Name: Keshan Disease 12 53 15 72
Caused by Deficiency of Selenium in the Diet 53
Enlarged Heart and Poor Heart Function 53

Classifications:



External Ids:

Disease Ontology 12 DOID:0050083
UMLS 72 C0268095

Summaries for Keshan Disease

Disease Ontology : 12 A nutritional deficiency that is disease characterized by a cardiomyopathy secondary to selenium deficiency.

MalaCards based summary : Keshan Disease, also known as caused by deficiency of selenium in the diet, is related to atrial standstill 1 and dilated cardiomyopathy. An important gene associated with Keshan Disease is GPX1 (Glutathione Peroxidase 1), and among its related pathways/superpathways are Allograft rejection and Immune response NFAT in immune response. The drugs Selenium and Micronutrients have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and thyroid, and related phenotype is immune system.

Wikipedia : 75 Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium... more...

Related Diseases for Keshan Disease

Graphical network of the top 20 diseases related to Keshan Disease:



Diseases related to Keshan Disease

Symptoms & Phenotypes for Keshan Disease

MGI Mouse Phenotypes related to Keshan Disease:

46 (showing 1, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 BMP5 BMP7 GPX1 HLA-DOA HLA-DQA1 ICAM1

Drugs & Therapeutics for Keshan Disease

Drugs for Keshan Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 7, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
2 Micronutrients Phase 3
3 Sodium Selenite Phase 3
4 Antioxidants Phase 3
5 Protective Agents Phase 3
6 Nutrients Phase 3
7 Trace Elements Phase 3

Interventional clinical trials:

(showing 2, show less)
# Name Status NCT ID Phase Drugs
1 Selenium Treatment and Chagasic Cardiopathy (STCC): A Prospective Randomized Trial in Patients With Chagas Disease Recruiting NCT00875173 Phase 3 Selenium;Placebo (for Selenium)
2 Myocardial Cell Vein Transplantation for Chronic Heart Failure Not yet recruiting NCT03759405 Phase 2, Phase 3

Search NIH Clinical Center for Keshan Disease

Genetic Tests for Keshan Disease

Anatomical Context for Keshan Disease

MalaCards organs/tissues related to Keshan Disease:

41
Heart, Liver, Thyroid, Whole Blood, Pancreatic Islet, Cardiac Myocytes

Publications for Keshan Disease

Articles related to Keshan Disease:

(showing 213, show less)
# Title Authors PMID Year
1
Citreoviridin induces myocardial apoptosis through PPAR-γ-mTORC2-mediated autophagic pathway and the protective effect of thiamine and selenium. 38
31419397 2019
2
Selenium (Se) Deficiency After Orthotopic Heart Transplantation (OHT) (P12-056-19). 38
31225078 2019
3
A Spatial Ecology Study of Keshan Disease and Hair Selenium. 38
30167961 2019
4
The Functional Analysis of Selenium-Related Genes and Magnesium-Related Genes in the Gene Expression Profile Microarray in the Peripheral Blood Mononuclear Cells of Keshan Disease. 38
31165343 2019
5
Efficacy of Long-term Selenium Supplementation in the Treatment of Chronic Keshan Disease with Congestive Heart Failure. 38
31016516 2019
6
The aggravating effect of selenium deficiency on T-2 toxin-induced damage on primary cardiomyocyte results from a reduction of protective autophagy. 38
30629952 2019
7
A spatial ecological study of selenoprotein P and Keshan disease. 38
30466925 2019
8
Environmental Selenium and Human Health: an Update. 38
30280317 2018
9
Prevention of Keshan Disease by Selenium Supplementation: a Systematic Review and Meta-analysis. 38
29627894 2018
10
Associations Between Selenium Content in Hair and Kashin-Beck Disease/Keshan Disease in Children in Northwestern China: a Prospective Cohort Study. 38
28983831 2018
11
Electrochemical Impedance Spectroscopy for Real-Time Detection of Lipid Membrane Damage Based on a Porous Self-Assembly Monolayer Support. 38
29786428 2018
12
Network Analysis of Se-and Zn-related Proteins in the Serum Proteomics Expression Profile of the Endemic Dilated Cardiomyopathy Keshan Disease. 38
28819918 2018
13
Selenium deficiency aggravates T-2 toxin-induced injury of primary neonatal rat cardiomyocytes through ER stress. 38
29454614 2018
14
Selenium deficiency in subtropical littoral pampas: environmental and dietary aspects. 38
28401376 2018
15
miR-2954 Inhibits PI3K Signaling and Induces Autophagy and Apoptosis in Myocardium Selenium Deficiency. 38
30463056 2018
16
Prediction of co-expression genes and integrative analysis of gene microarray and proteomics profile of Keshan disease. 38
29321553 2018
17
Serum quantitative proteomic analysis of patients with keshan disease based on iTRAQ labeling technique: A first term study. 38
28965596 2017
18
Preliminary quantitative proteomics analysis in chronic and latent Keshan disease by iTRAQ labeling approach. 38
29285290 2017
19
Mitochondrial activity and oxidative stress functions are influenced by the activation of AhR-induced CYP1A1 overexpression in cardiomyocytes. 38
28498411 2017
20
Health risk assessment of environmental selenium: Emerging evidence and challenges (Review). 38
28339083 2017
21
Roles of Glycoproteins in the Diagnosis and Differential Diagnosis of Chronic and Latent Keshan Disease. 38
28481304 2017
22
An approach to assessment of Keshan disease elimination at the township level. 38
27821502 2016
23
[Progressive Risks of Latent Keshan Disease: a Long Term Follow-up Study]. 38
27468488 2016
24
Metabolism of arachidonic acid by the cytochrome P450 enzyme in patients with chronic Keshan disease and dilated cardiomyopathy. 38
26893848 2016
25
Selenoproteins and cardiovascular stress. 38
25354851 2015
26
Selenium deficiency associated porcine and human cardiomyopathies. 38
25456335 2015
27
Involvement of caspases and their upstream regulators in myocardial apoptosis in a rat model of selenium deficiency-induced dilated cardiomyopathy. 38
26004897 2015
28
Biomonitoring Equivalents for selenium. 38
25068883 2014
29
H558R polymorphism in SCN5A is associated with Keshan disease and QRS prolongation in Keshan disease patients. 38
25177937 2014
30
Serum biomarkers of Keshan disease assessed using a protein profiling approach based on ClinProt technique. 38
24841853 2014
31
TLR2-ICAM1-Gadd45α axis mediates the epigenetic effect of selenium on DNA methylation and gene expression in Keshan disease. 38
24811888 2014
32
Keshan disease, selenium deficiency, and the selenoproteome. 38
24785212 2014
33
Mercury (Hg) and oxidative stress status in healthy mothers and its effect on birth anthropometric measures. 38
24332576 2014
34
Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease. 38
24384427 2014
35
Long-term prognostic value of major and minor ECG abnormalities in latent Keshan disease with suspect chronic Keshan disease. 38
24975014 2014
36
[Comparative study on condition and related factors of Keshan disease and dilated cardiomyopathy in Shandong province]. 38
24779040 2014
37
Mitochondrial-related gene expression profiles suggest an important role of PGC-1alpha in the compensatory mechanism of endemic dilated cardiomyopathy. 38
23954821 2013
38
The prevalence of Keshan disease in China. 38
23218571 2013
39
Comparing gene expression profiles of Kashin-Beck and Keshan diseases occurring within the same endemic areas of China. 38
23729183 2013
40
[Screening of differentially expressed proteins in serum from subjects with Keshan disease by two-dimensional electrophoresis and mass and mass spectrometry]. 38
23805519 2013
41
[Two-dimensional gel electrophoresis map of serum proteins in patients with chronic Keshan disease]. 38
23898519 2013
42
Oxidative stress is involved in the pathogenesis of Keshan disease (an endemic dilated cardiomyopathy) in China. 38
24062877 2013
43
Medical geology of arsenic, selenium and thallium in China. 38
21440288 2012
44
An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). 38
22705420 2012
45
Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China. 38
22180033 2011
46
Suboptimal selenium supply--a continuing problem in Keshan disease areas in Heilongjiang province. 38
21253891 2011
47
The effect of DHEA treatment on the oxidative stress and myocardial fibrosis induced by Keshan disease pathogenic factors. 38
21602037 2011
48
Selenium in human health and disease. 38
20812787 2011
49
Is selenium deficiency really the cause of Keshan disease? 38
20574681 2011
50
Characterization and expression of chicken selenoprotein W. 38
21207117 2011
51
Selenium deficiency contributes to the chronic myocarditis in coxsackievirus-infected mice. 38
21434702 2011
52
Selenium level surveillance for the year 2007 of Keshan disease in endemic areas and analysis on surveillance results between 2003 and 2007. 38
20180046 2010
53
[Surveys on the conditions of Keshan disease and selenium levels of 15 counties in Shandong Province in 2008]. 38
20726240 2010
54
[Polymorphisms in the glutathione peroxidase-1 gene associated with increased risk of Keshan disease]. 38
21055077 2010
55
Chronic exposure to cereal mycotoxin likely citreoviridin may be a trigger for Keshan disease mainly through oxidative stress mechanism. 38
20034747 2010
56
Heart failure secondary to selenium deficiency, reversible after supplementation. 38
19059654 2010
57
Soils and geomedicine. 38
19350398 2009
58
[Surveillance on Keshan disease from 1990 to 2008 in Sichuan province]. 38
20193206 2009
59
Circulating adhesion molecules in patients with Keshan disease and their relationship with Coxsackie B virus infection. 38
19399399 2009
60
Effects of Fusarium mycotoxin butenolide on myocardial mitochondria in vitro. 38
19778250 2009
61
Selenoproteins. 38
18757362 2009
62
Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy. 38
18940188 2009
63
Lipid peroxidation and antioxidant defense impairment in the hearts of chick embryos induced by in ovo exposure to Fusarium mycotoxin butenolide. 38
18775738 2008
64
[Observation on conditions and related factors of Keshan disease in Shandong province, 1990-2007]. 38
19035191 2008
65
Host-pathogen evolution: Implications for the prevention and treatment of malaria, myocardial infarction and AIDS. 38
17590522 2008
66
Toxic effects of Fusarium mycotoxin butenolide on rat myocardium and primary culture of cardiac myocytes. 38
17603091 2007
67
[Pathological study of unexpected sudden death clustered in family or village in Yunnan province: report of 29 cases of autopsy]. 38
18001532 2007
68
[Dynamic observation on the relationship between the Keshan disease incidence and some element in internal and external environment in Shanxi Province]. 38
17953208 2007
69
[The study on relation of HLA-DRB1 gene polymorphism to Keshan disease and its association and linkage in the core families]. 38
17285554 2007
70
Selenium. 38
17913229 2007
71
Keshan disease and mitochondrial cardiomyopathy. 38
17312989 2006
72
Microarray analysis of selenium-depleted and selenium-supplemented mice. 38
16444006 2006
73
[Selenium and cardiovascular disease: selected issues]. 38
17199104 2006
74
Arsenic and selenium in human hair: a comparison of five countries with and without arsenicosis. 38
16116245 2005
75
Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. 38
15485910 2004
76
Coxsackievirus B3 infection and its mutation in Keshan disease. 38
15484304 2004
77
Assessment of requirements for selenium and adequacy of selenium status: a review. 38
14985676 2004
78
Geochemical environment and health problems in China. 38
15214616 2004
79
Selenium deficiency and viral infection. 38
12730444 2003
80
[Coxsackievirus B3 infection and Keshan disease]. 38
12600035 2002
81
HIV-associated cardiomyopathy is not Keshan disease. 38
12042392 2002
82
Multifocal myocardial necrosis: a distinctive cardiac lesion in cystic fibrosis, lipomatous pancreatic atrophy, and Keshan disease. 38
12056507 2002
83
Rationale for clinical trials of selenium as an antioxidant for the treatment of the cardiomyopathy of Friedreich's ataxia. 38
11812188 2002
84
Selenium in soil and endemic diseases in China. 38
11846167 2002
85
Fulminant heart failure due to selenium deficiency cardiomyopathy (Keshan disease). 38
11848134 2002
86
[Keshan disease--a review from the aspect of history and etiology]. 38
11868394 2002
87
Selenite inhibition of Coxsackie virus B5 replication: implications on the etiology of Keshan disease. 38
11878751 2002
88
[Effect of methionine supplementation on the selenium bioavailability in rats fed on grains from Keshan disease endemic area]. 38
11255767 2001
89
Thermal stability of moniliformin at varying temperature, pH, and time in an aqueous environment. 38
11079708 2000
90
Characterization of enterovirus isolates from patients with heart muscle disease in a selenium-deficient area of China. 38
11015360 2000
91
Regional ecological risk assessment of selenium in Jilin province, China. 38
11059846 2000
92
Effects of selenium deficiency on the rat myocardial protein pattern-- investigation by two-dimensional gel electrophoresis. 38
10879621 2000
93
High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China. 38
10814633 2000
94
Selenium supplementation of children in a selenium-deficient area in China: blood selenium levels and glutathione peroxidase activities. 38
11049204 2000
95
[Review on the study of Keshan disease in China]. 38
10682506 1999
96
Selenium. 38
10382553 1999
97
Selenium and viral virulence. 38
10746343 1999
98
Aurothioglucose inhibits murine thioredoxin reductase activity in vivo. 38
9915899 1999
99
Alterations in rat pancreatic islet beta cells induced by Keshan disease pathogenic factors: protective action of selenium and vitamin E. 38
9550538 1998
100
[Protein status and antioxidant capability of residents in endemic and nonendemic areas of Keshan disease(KD)]. 38
10682627 1998
101
[Morphological studies of myocardial fibrosis in different types of Keshan disease]. 38
11244934 1998
102
[Selenium in health and disease]. 38
9789432 1998
103
Vitamin E Status and Neurodegenerative Disease. 38
27406331 1998
104
Changes in myocardial thyroid hormone metabolism and alpha-glycerophosphate dehydrogenase activity in rats deficient in iodine and selenium. 38
9389891 1997
105
Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice. 38
9315324 1997
106
Selenium requirements as discussed in the 1996 joint FAO/IAEA/WHO expert consultation on trace elements in human nutrition. 38
9315313 1997
107
Further investigation on the role of selenium deficiency in the aetiology and pathogenesis of Keshan disease. 38
9315325 1997
108
Interacting nutritional and infectious etiologies of Keshan disease. Insights from coxsackie virus B-induced myocarditis in mice deficient in selenium or vitamin E. 38
9152508 1997
109
Genomic structures of viral agents in relation to the biosynthesis of selenoproteins. 38
9152512 1997
110
[A survey of moniliformin in rice and corn sampled from the areas with and without Keshan disease]. 38
9208523 1996
111
[Effects of selenium and germanium on lipid peroxidation in rats fed with low-selenium grain]. 38
8758855 1996
112
Selenium as a risk factor for cardiovascular diseases. 38
8783029 1996
113
[Trace elements in long-term total parenteral nutrition]. 38
8587186 1996
114
A survey of moniliformin contamination in rice and corn from Keshan disease endemic and non-KSD areas in China. 38
8719174 1995
115
Studies on human dietary requirements and safe range of dietary intakes of selenium in China and their application in the prevention of related endemic diseases. 38
8561918 1995
116
[Effects of selenium and vitamin E on arachidonic acid metabolism in experimental myocardial ischaemia]. 38
8556938 1995
117
[Detection of enteroviral RNA in paraffin-embedded myocardial tissue from patients with Keshan by nested PCR]. 38
7553145 1995
118
[Selenium deficiency and thyroid hormone metabolism and function]. 38
7604216 1995
119
Antioxidant status, erythrocyte fatty acids, and mortality from cardiovascular disease and Keshan disease in China. 38
7956986 1994
120
Selenium deficiency in HIV infection and the acquired immunodeficiency syndrome (AIDS). 38
8194134 1994
121
Benign human enterovirus becomes virulent in selenium-deficient mice. 38
8083665 1994
122
[Studies on the effects of low-dose selenium and high-dose cadmium on myocardial injury]. 38
7924656 1994
123
Factors affecting the selenium intake of people in Transbaikalian Russia. 38
7517165 1994
124
Effects of selenium and alpha-tocopherol on liver damage induced by feeding grains from an endemic area of Keshan disease in rats. 38
7969093 1994
125
Study of a low-selenium environment in China by INAA and Mössbauer spectrometry. 38
7710825 1994
126
Postmortem serum selenium concentrations and their possible etiological role in sudden infant death (SID). 38
8225137 1993
127
Vitamin E requirement of rats fed on a diet containing grains from the endemic region of Keshan disease. 38
8397903 1993
128
[Immunohistochemical studies of islet lesions in Keshan disease patients and rats fed with grains from endemic area of the disease]. 38
8221984 1993
129
[Effects of low calcium on myocardial necrosis of Keshan disease by food preference]. 38
8221983 1993
130
Ultrastructural study of moniliformin induced lesions of myocardium in rats and mice. 38
8476531 1993
131
The epidemiology of selenium deficiency in the etiological study of endemic diseases in China. 38
8427200 1993
132
[Concentration of trace elements in hair from children living in a Keshan disease district in China]. 38
1464948 1992
133
Relationship between dietary fatty acid, selenium, and degenerative cardiomyopathy. 38
1435394 1992
134
A low plasma selenium is a risk factor for peripartum cardiomyopathy. A comparative study in Sahelian Africa. 38
1428253 1992
135
[Keshan disease and the selenium content of grains in Yunnan province]. 38
1606866 1992
136
Fatty acid composition of blood lipids in Chinese children consuming high erucic acid rapeseed oil. 38
1492753 1992
137
Scientific rationale for the 1989 recommended dietary allowance for selenium. 38
1960351 1991
138
Damage to hepatic thyroxine 5'-deiodination induced by pathogenic factors of Keshan disease and the preventive effects of selenium and vitamin E. 38
1781930 1991
139
Effect of sodium nitrite on myocardial glutathione peroxidase and protective action of vitamin E and selenium. 38
1781932 1991
140
Effect of moniliformin on myocardial contractility in rats. 38
1764219 1991
141
[Ultrastructural changes of myocardial biopsy from six children with latent Keshan disease]. 38
1782692 1991
142
[Pharmacokinetics of sodium selenite in human body at different levels of selenium]. 38
1664167 1991
143
Selenium in pediatric nutrition. 38
2000274 1991
144
[Assay of moniliformin content in household grains from families in patients with Keshan disease]. 38
1850646 1991
145
The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million. 38
2096847 1990
146
[Ultrastructural study of moniliformin-induced lesions on the myocardium of rats and mice]. 38
1963352 1990
147
[Protective effects of vitamin E and selenium on myocardial mitochondria in rats--a study on the pathogenic factors and pathogenesis of Keshan disease]. 38
2209265 1990
148
[Study of oxidative damage on mitochondrial membrane of myocardium deficient in selenium]. 38
2167777 1990
149
[Contents of elements in the myocardium in patients with Keshan disease]. 38
2168799 1990
150
A study on the inhibition of rat myocardium glutathione peroxidase and glutathione reductase by moniliformin. 38
2366852 1990
151
[Pharmacokinetic study of sodium selenite in low-selenium rabbits]. 38
2177311 1990
152
Common denominators in the etiology and pathology of visceral lesions of cystic fibrosis and Keshan disease. 38
1702672 1990
153
Selenium and cardiovascular disease. 38
1702669 1990
154
[An insufficiency of essential trace elements and its manifestations in pathology]. 38
2196034 1990
155
[Hyposelenoses]. 38
2128681 1990
156
Reduced cardiac selenium content in the acquired immunodeficiency syndrome. 38
2614866 1989
157
Reversible cardiomyopathy due to selenium deficiency. 38
2614867 1989
158
Biochemical studies of a selenium-deficient population in China: measurement of selenium, glutathione peroxidase and other oxidant defense indices in blood. 38
2795246 1989
159
Pathologic anatomy of the dilated cardiomyopathies. 38
2756900 1989
160
Increased sarcolemmal membrane permeability of cardiac muscle cells in rats fed grains cultivated in a Keshan disease endemic area: a study with horseradish peroxidase as a tracer. 38
2721651 1989
161
[Study on toxicological mechanism of moniliformin]. 38
2800548 1989
162
[Selenium: physiologic role and value in human pathology]. 38
3059285 1988
163
Keshan disease--an endemic mitochondrial cardiomyopathy in China. 38
2908794 1988
164
Keshan disease: an entity or not. 38
3402979 1988
165
[Care of patients with acute Keshan disease]. 38
3197191 1988
166
[Experience in the nursing care of patients with Keshan disease: report of 411 cases]. 38
3197190 1988
167
Selenium: geochemical distribution and associations with human heart and cancer death rates and longevity in China and the United States. 38
2484511 1988
168
Selenium in total parenteral nutrition. 38
2484513 1988
169
Selenite metabolism in rat and human blood. 38
2484530 1988
170
[Keshan disease--a kind of "mitochondrial cardiomyopathy"]. 38
2834901 1987
171
Pancreatic lesions of Keshan disease and its significances. 38
3129250 1987
172
Report on the 1986 A.S.P.E.N. Research Workshop on selenium in clinical nutrition. 38
3098995 1986
173
The two faces of selenium-deficiency and toxicity--are similar in animals and man. 38
3527390 1986
174
Selenium and cardiomyopathy (Keshan disease). 38
3776583 1986
175
[Histochemical change in succinyl dehydrogenase activity in the liver of mice fed with a diet from the region endemic for Keshan disease]. 38
4085303 1985
176
Keshan disease: an endemic cardiomyopathy in China. 38
3997137 1985
177
Effect of selenium deficiency on hydroperoxide-induced glutathione release from the isolated perfused rat heart. 38
3998867 1985
178
M-mode echocardiographic features of children with Keshan disease. A preliminary observation of 106 cases. 38
6242288 1984
179
[Keshan disease--endemic myocardial disease]. 38
6518874 1984
180
[Keshan disease (endemic cardiomyopathy)]. 38
6725542 1984
181
The role of selenium in Keshan disease. 38
6507187 1984
182
[The relationship between selenium and etiology of Keshan disease]. 38
6678485 1983
183
[Electron microscopic observations on endomyocardial biopsy specimens from patients with Keshan disease]. 38
6418354 1983
184
Selenium interactions with carcinogens. 38
6416916 1983
185
[A Preliminary study on the immunological pathogenesis of Keshan disease]. 38
6653216 1983
186
Nutritional bio-geochemical etiology of Keshan disease. 38
6416757 1983
187
[Plasma and erythrocyte levels of selenium and lipids in children with Keshan disease and their pathogenic significance]. 38
6628222 1983
188
Endemic selenium intoxication of humans in China. 38
6846228 1983
189
Pathology of Keshan disease. A comprehensive review. 38
6413138 1983
190
Keshan disease-an endemic cardiomyopathy in China. 38
6412443 1983
191
A study of nutritional and bio-geochemical factors in the occurrence and development of Keshan disease. 38
7131711 1982
192
Selenium deficiency and fatal cardiomyopathy in a patient on home parenteral nutrition. 38
6807740 1982
193
[A study of the relationship between distribution of myocardial foci and coronary blood vessels in Keshan disease I. The pathogenesis of peri-vascular foci]. 38
7128439 1982
194
Keshan disease and selenium in China. 38
7075240 1982
195
[Keshan disease in children and its dietary prevention (author's transl]. 38
6800610 1981
196
[Congestive (dilated type) cardiomyopathy and chronic Keshan disease (a roentgeno-pathological corrective study) (author's transl)]. 38
6461517 1981
197
Metabolic and functional defects in selenium deficiency. 38
6118889 1981
198
[Observation on the effects of adding selenium to table salt for prevention of Keshan disease (author's transl)]. 38
7333186 1981
199
[An investigation of the nature and etiology of the myocardial changes in patients with acute Keshan disease (author's transl)]. 38
7318658 1981
200
[Investigations on distributional relationship between Keshan disease and Se feficiency in animals in Shanxi Province (author's transl)]. 38
7307823 1981
201
[Preliminary observations on the echocardiographic features of 84 cases of Keshan disease (author's transl)]. 38
7297262 1980
202
[Studies of mechanocardiography in Keshan disease (author's transl)]. 38
7307944 1980
203
Studies on the relations of selenium and Keshan disease. 38
24272892 1980
204
[Selenium level in the body of susceptibles of Keshan disease (author's transl)]. 38
7227077 1980
205
[The relationship between seasonal prevalence of Keshan disease and hair selenium level of local inhabitants (author's transl)]. 38
7227078 1980
206
[Research on the relation between selenium and Keshan disease (author's transl)]. 38
262817 1979
207
Observations on effect of sodium selenite in prevention of Keshan disease. 38
114371 1979
208
Epidemiologic studies on the etiologic relationship of selenium and Keshan disease. 38
114372 1979
209
On the etiology of Keshan disease: two hypotheses. 38
110554 1979
210
[The difference between whole blood and hair selenium levels of inhabitants in the endemic and nonendemic areas of Keshan disease (author's transl)]. 38
555741 1979
211
[The difference between the urinary selenium excretion of the children in the endemic and non-endemic areas of Keshan disease (author's transl)]. 38
555742 1979
212
The vetosidum in the treatment of Keshan disease. 38
411634 1977
213
PATHOLOGIC CHANGES OF THE CONDUCTION SYSTEM OF THE HEART IN 43 CASES OF KESHAN DISEASE. 38
14191216 1964

Variations for Keshan Disease

Expression for Keshan Disease

Search GEO for disease gene expression data for Keshan Disease.

Pathways for Keshan Disease

Pathways related to Keshan Disease according to GeneCards Suite gene sharing:

(showing 21, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.59 ICAM1 HLA-DRA HLA-DQA1 HLA-DOA
2
Show member pathways
12.33 HLA-DRA HLA-DQA1 HLA-DOA
3
Show member pathways
12.3 HLA-DRA HLA-DQA1 HLA-DOA
4
Show member pathways
12.23 ICAM1 HLA-DRA HLA-DQA1
5
Show member pathways
12.11 HLA-DRA HLA-DQA1 HLA-DOA
6
Show member pathways
11.99 HLA-DRA HLA-DQA1 HLA-DOA
7 11.92 HLA-DRA HLA-DQA1 HLA-DOA
8 11.9 ICAM1 HLA-DRA HLA-DQA1 HLA-DOA
9 11.81 HLA-DRA HLA-DQA1 HLA-DOA
10
Show member pathways
11.78 ICAM1 BMP7 BMP5
11
Show member pathways
11.66 HLA-DRA HLA-DQA1 HLA-DOA
12 11.62 ICAM1 HLA-DRA HLA-DQA1 HLA-DOA
13 11.59 HLA-DRA HLA-DQA1 HLA-DOA
14 11.59 HLA-DRA HLA-DQA1 HLA-DOA
15 11.53 HLA-DRA HLA-DQA1 HLA-DOA
16 11.35 HLA-DRA HLA-DQA1 HLA-DOA
17 11.34 TNFSF15 HLA-DRA
18 11.29 HLA-DRA HLA-DQA1 HLA-DOA
19 11.23 ICAM1 HLA-DRA HLA-DQA1 HLA-DOA
20 10.91 ICAM1 HLA-DRA HLA-DQA1 HLA-DOA
21 10.82 BMP7 BMP5

GO Terms for Keshan Disease

Cellular components related to Keshan Disease according to GeneCards Suite gene sharing:

(showing 9, show less)
# Name GO ID Score Top Affiliating Genes
1 lysosome GO:0005764 9.61 HLA-DRA HLA-DQA1 HLA-DOA
2 lysosomal membrane GO:0005765 9.5 HLA-DRA HLA-DQA1 HLA-DOA
3 endocytic vesicle membrane GO:0030666 9.46 HLA-DRA HLA-DQA1
4 ER to Golgi transport vesicle membrane GO:0012507 9.4 HLA-DRA HLA-DQA1
5 transport vesicle membrane GO:0030658 9.37 HLA-DRA HLA-DQA1
6 endosome membrane GO:0010008 9.33 HLA-DRA HLA-DQA1 HLA-DOA
7 clathrin-coated endocytic vesicle membrane GO:0030669 9.26 HLA-DRA HLA-DQA1
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DRA HLA-DQA1
9 MHC class II protein complex GO:0042613 8.8 HLA-DRA HLA-DQA1 HLA-DOA

Biological processes related to Keshan Disease according to GeneCards Suite gene sharing:

(showing 24, show less)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.86 TNFSF15 HLA-DRA HLA-DQA1 HLA-DOA
2 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.67 HLA-DRA HLA-DQA1 HLA-DOA
3 pattern specification process GO:0007389 9.62 BMP7 BMP5
4 positive regulation of epithelial cell proliferation GO:0050679 9.61 SCN5A BMP5
5 regulation of MAPK cascade GO:0043408 9.61 BMP7 BMP5
6 cell development GO:0048468 9.6 BMP7 BMP5
7 SMAD protein signal transduction GO:0060395 9.59 BMP7 BMP5
8 odontogenesis of dentin-containing tooth GO:0042475 9.58 SCN5A BMP7
9 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.58 BMP7 BMP5
10 hindbrain development GO:0030902 9.57 BMP7 BMP5
11 pharyngeal system development GO:0060037 9.55 BMP7 BMP5
12 cardiac muscle tissue development GO:0048738 9.54 BMP7 BMP5
13 interferon-gamma-mediated signaling pathway GO:0060333 9.54 ICAM1 HLA-DRA HLA-DQA1
14 positive regulation of dendrite development GO:1900006 9.52 BMP7 BMP5
15 cardiac septum morphogenesis GO:0060411 9.51 BMP7 BMP5
16 pericardium morphogenesis GO:0003344 9.48 BMP7 BMP5
17 heart trabecula morphogenesis GO:0061384 9.46 BMP7 BMP5
18 chorio-allantoic fusion GO:0060710 9.43 BMP7 BMP5
19 antigen processing and presentation GO:0019882 9.43 HLA-DRA HLA-DQA1 HLA-DOA
20 endocardial cushion formation GO:0003272 9.4 BMP7 BMP5
21 neural fold elevation formation GO:0021502 9.32 BMP7 BMP5
22 allantois development GO:1905069 9.16 BMP7 BMP5
23 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.13 ICAM1 GPX1 BMP5
24 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.8 HLA-DRA HLA-DQA1 HLA-DOA

Molecular functions related to Keshan Disease according to GeneCards Suite gene sharing:

(showing 6, show less)
# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 TNFSF15 BMP7 BMP5
2 transforming growth factor beta receptor binding GO:0005160 9.37 BMP7 BMP5
3 peptide antigen binding GO:0042605 9.32 HLA-DRA HLA-DQA1
4 MHC class II protein complex binding GO:0023026 9.16 HLA-DRA HLA-DOA
5 BMP receptor binding GO:0070700 8.96 BMP7 BMP5
6 MHC class II receptor activity GO:0032395 8.8 HLA-DRA HLA-DQA1 HLA-DOA

Sources for Keshan Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....