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MCID: KSH001
MIFTS: 33

Keshan Disease

Categories: Cardiovascular diseases, Metabolic diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Keshan Disease

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MalaCards integrated aliases for Keshan Disease:

Name: Keshan Disease 12 52 15 71
Caused by Deficiency of Selenium in the Diet 52
Enlarged Heart and Poor Heart Function 52

Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050083
UMLS 71 C0268095
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Summaries for Keshan Disease

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Disease Ontology : 12 A nutritional deficiency that is disease characterized by a cardiomyopathy secondary to selenium deficiency.

MalaCards based summary : Keshan Disease, also known as caused by deficiency of selenium in the diet, is related to atrial standstill 1 and dilated cardiomyopathy. An important gene associated with Keshan Disease is GPX1 (Glutathione Peroxidase 1), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and Folate Metabolism. The drugs Selenium and Trace Elements have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and liver.

Wikipedia : 74 Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium... more...

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Related Diseases for Keshan Disease

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Diseases related to Keshan Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 20, show less)
# Related Disease Score Top Affiliating Genes
1 atrial standstill 1 10.6
2 dilated cardiomyopathy 10.5
3 progressive familial heart block, type ia 10.4
4 progressive familial heart block, type ib 10.4
5 right bundle branch block 10.4
6 kashin-beck disease 10.3
7 cystic fibrosis 10.2
8 heart disease 10.2
9 congestive heart failure 10.2
10 myocarditis 10.2
11 optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy 10.1
12 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
13 hypertensive heart disease 10.1
14 vaccinia 10.1
15 myopathy 10.1
16 tremor 10.1
17 glutathione peroxidase deficiency 9.8 GPX3 GPX1
18 staphyloenterotoxemia 9.5 SELENOK MSRB1
19 ileocolitis 9.5 GPX3 GPX1
20 rigid spine muscular dystrophy 1 9.4 SELENOW SELENOT MSRB1

Graphical network of the top 20 diseases related to Keshan Disease:



Diseases related to Keshan Disease
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Symptoms & Phenotypes for Keshan Disease

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Drugs & Therapeutics for Keshan Disease

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Drugs for Keshan Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 7, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
2 Trace Elements Phase 3
3 Micronutrients Phase 3
4 Antioxidants Phase 3
5 Nutrients Phase 3
6 Sodium Selenite Phase 3
7 Protective Agents Phase 3

Interventional clinical trials:

(showing 2, show less)
# Name Status NCT ID Phase Drugs
1 Selenium Treatment and Chagasic Cardiopathy (STCC): A Prospective Randomized Trial in Patients With Chagas Disease Recruiting NCT00875173 Phase 3 Selenium;Placebo (for Selenium)
2 Myocardial Cell Vein Transplantation for Chronic Heart Failure Not yet recruiting NCT03759405 Phase 2, Phase 3

Search NIH Clinical Center for Keshan Disease

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Genetic Tests for Keshan Disease

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Anatomical Context for Keshan Disease

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MalaCards organs/tissues related to Keshan Disease:

40
Heart, T Cells, Liver, Thyroid, Whole Blood, Pancreatic Islet, Cardiac Myocytes
Sources

Publications for Keshan Disease

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Articles related to Keshan Disease:

(showing 215, show less)
# Title Authors PMID Year
1
The proteomic profiling of multiple tissue damage in chickens for a selenium deficiency biomarker discovery. 61
32022057 2020
2
The Functional Analysis of Selenium-Related Genes and Magnesium-Related Genes in the Gene Expression Profile Microarray in the Peripheral Blood Mononuclear Cells of Keshan Disease. 61
31165343 2019
3
Citreoviridin induces myocardial apoptosis through PPAR-γ-mTORC2-mediated autophagic pathway and the protective effect of thiamine and selenium. 61
31419397 2019
4
A Spatial Ecology Study of Keshan Disease and Hair Selenium. 61
30167961 2019
5
Efficacy of Long-term Selenium Supplementation in the Treatment of Chronic Keshan Disease with Congestive Heart Failure. 61
31016516 2019
6
The aggravating effect of selenium deficiency on T-2 toxin-induced damage on primary cardiomyocyte results from a reduction of protective autophagy. 61
30629952 2019
7
H2S Protects against Cardiac Cell Hypertrophy through Regulation of Selenoproteins. 61
31583042 2019
8
Expression Profile Analysis of Selenium-Related Genes in Peripheral Blood Mononuclear Cells of Patients with Keshan Disease. 61
31828104 2019
9
A spatial ecological study of selenoprotein P and Keshan disease. 61
30466925 2019
10
Environmental Selenium and Human Health: an Update. 61
30280317 2018
11
Prevention of Keshan Disease by Selenium Supplementation: a Systematic Review and Meta-analysis. 61
29627894 2018
12
Associations Between Selenium Content in Hair and Kashin-Beck Disease/Keshan Disease in Children in Northwestern China: a Prospective Cohort Study. 61
28983831 2018
13
Electrochemical Impedance Spectroscopy for Real-Time Detection of Lipid Membrane Damage Based on a Porous Self-Assembly Monolayer Support. 61
29786428 2018
14
Network Analysis of Se-and Zn-related Proteins in the Serum Proteomics Expression Profile of the Endemic Dilated Cardiomyopathy Keshan Disease. 61
28819918 2018
15
Selenium deficiency aggravates T-2 toxin-induced injury of primary neonatal rat cardiomyocytes through ER stress. 61
29454614 2018
16
Selenium deficiency in subtropical littoral pampas: environmental and dietary aspects. 61
28401376 2018
17
miR-2954 Inhibits PI3K Signaling and Induces Autophagy and Apoptosis in Myocardium Selenium Deficiency. 61
30463056 2018
18
Prediction of co-expression genes and integrative analysis of gene microarray and proteomics profile of Keshan disease. 61
29321553 2018
19
Serum quantitative proteomic analysis of patients with keshan disease based on iTRAQ labeling technique: A first term study. 61
28965596 2017
20
Preliminary quantitative proteomics analysis in chronic and latent Keshan disease by iTRAQ labeling approach. 61
29285290 2017
21
Mitochondrial activity and oxidative stress functions are influenced by the activation of AhR-induced CYP1A1 overexpression in cardiomyocytes. 61
28498411 2017
22
Health risk assessment of environmental selenium: Emerging evidence and challenges (Review). 61
28339083 2017
23
Roles of Glycoproteins in the Diagnosis and Differential Diagnosis of Chronic and Latent Keshan Disease. 61
28481304 2017
24
An approach to assessment of Keshan disease elimination at the township level. 61
27821502 2016
25
[Progressive Risks of Latent Keshan Disease: a Long Term Follow-up Study]. 61
27468488 2016
26
Metabolism of arachidonic acid by the cytochrome P450 enzyme in patients with chronic Keshan disease and dilated cardiomyopathy. 61
26893848 2016
27
Selenoproteins and cardiovascular stress. 61
25354851 2015
28
Selenium deficiency associated porcine and human cardiomyopathies. 61
25456335 2015
29
Involvement of caspases and their upstream regulators in myocardial apoptosis in a rat model of selenium deficiency-induced dilated cardiomyopathy. 61
26004897 2015
30
Biomonitoring Equivalents for selenium. 61
25068883 2014
31
H558R polymorphism in SCN5A is associated with Keshan disease and QRS prolongation in Keshan disease patients. 61
25177937 2014
32
Serum biomarkers of Keshan disease assessed using a protein profiling approach based on ClinProt technique. 61
24841853 2014
33
TLR2-ICAM1-Gadd45α axis mediates the epigenetic effect of selenium on DNA methylation and gene expression in Keshan disease. 61
24811888 2014
34
Keshan disease, selenium deficiency, and the selenoproteome. 61
24785212 2014
35
Mercury (Hg) and oxidative stress status in healthy mothers and its effect on birth anthropometric measures. 61
24332576 2014
36
Long-term prognostic value of major and minor ECG abnormalities in latent Keshan disease with suspect chronic Keshan disease. 61
24975014 2014
37
Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease. 61
24384427 2014
38
[Comparative study on condition and related factors of Keshan disease and dilated cardiomyopathy in Shandong province]. 61
24779040 2014
39
Mitochondrial-related gene expression profiles suggest an important role of PGC-1alpha in the compensatory mechanism of endemic dilated cardiomyopathy. 61
23954821 2013
40
The prevalence of Keshan disease in China. 61
23218571 2013
41
Comparing gene expression profiles of Kashin-Beck and Keshan diseases occurring within the same endemic areas of China. 61
23729183 2013
42
[Screening of differentially expressed proteins in serum from subjects with Keshan disease by two-dimensional electrophoresis and mass and mass spectrometry]. 61
23805519 2013
43
[Two-dimensional gel electrophoresis map of serum proteins in patients with chronic Keshan disease]. 61
23898519 2013
44
Oxidative stress is involved in the pathogenesis of Keshan disease (an endemic dilated cardiomyopathy) in China. 61
24062877 2013
45
Medical geology of arsenic, selenium and thallium in China. 61
21440288 2012
46
An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). 61
22705420 2012
47
Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China. 61
22180033 2011
48
Suboptimal selenium supply--a continuing problem in Keshan disease areas in Heilongjiang province. 61
21253891 2011
49
The effect of DHEA treatment on the oxidative stress and myocardial fibrosis induced by Keshan disease pathogenic factors. 61
21602037 2011
50
Selenium in human health and disease. 61
20812787 2011
51
Is selenium deficiency really the cause of Keshan disease? 61
20574681 2011
52
Characterization and expression of chicken selenoprotein W. 61
21207117 2011
53
Selenium deficiency contributes to the chronic myocarditis in coxsackievirus-infected mice. 61
21434702 2011
54
Selenium level surveillance for the year 2007 of Keshan disease in endemic areas and analysis on surveillance results between 2003 and 2007. 61
20180046 2010
55
[Surveys on the conditions of Keshan disease and selenium levels of 15 counties in Shandong Province in 2008]. 61
20726240 2010
56
[Polymorphisms in the glutathione peroxidase-1 gene associated with increased risk of Keshan disease]. 61
21055077 2010
57
Chronic exposure to cereal mycotoxin likely citreoviridin may be a trigger for Keshan disease mainly through oxidative stress mechanism. 61
20034747 2010
58
Heart failure secondary to selenium deficiency, reversible after supplementation. 61
19059654 2010
59
Soils and geomedicine. 61
19350398 2009
60
[Surveillance on Keshan disease from 1990 to 2008 in Sichuan province]. 61
20193206 2009
61
Circulating adhesion molecules in patients with Keshan disease and their relationship with Coxsackie B virus infection. 61
19399399 2009
62
Effects of Fusarium mycotoxin butenolide on myocardial mitochondria in vitro. 61
19778250 2009
63
Selenoproteins. 61
18757362 2009
64
Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy. 61
18940188 2009
65
Lipid peroxidation and antioxidant defense impairment in the hearts of chick embryos induced by in ovo exposure to Fusarium mycotoxin butenolide. 61
18775738 2008
66
[Observation on conditions and related factors of Keshan disease in Shandong province, 1990-2007]. 61
19035191 2008
67
Host-pathogen evolution: Implications for the prevention and treatment of malaria, myocardial infarction and AIDS. 61
17590522 2008
68
Toxic effects of Fusarium mycotoxin butenolide on rat myocardium and primary culture of cardiac myocytes. 61
17603091 2007
69
[Pathological study of unexpected sudden death clustered in family or village in Yunnan province: report of 29 cases of autopsy]. 61
18001532 2007
70
[Dynamic observation on the relationship between the Keshan disease incidence and some element in internal and external environment in Shanxi Province]. 61
17953208 2007
71
[The study on relation of HLA-DRB1 gene polymorphism to Keshan disease and its association and linkage in the core families]. 61
17285554 2007
72
Selenium. 61
17913229 2007
73
Keshan disease and mitochondrial cardiomyopathy. 61
17312989 2006
74
Microarray analysis of selenium-depleted and selenium-supplemented mice. 61
16444006 2006
75
[Selenium and cardiovascular disease: selected issues]. 61
17199104 2006
76
Arsenic and selenium in human hair: a comparison of five countries with and without arsenicosis. 61
16116245 2005
77
Coxsackievirus B3 infection and its mutation in Keshan disease. 61
15484304 2004
78
Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. 61
15485910 2004
79
Assessment of requirements for selenium and adequacy of selenium status: a review. 61
14985676 2004
80
Geochemical environment and health problems in China. 61
15214616 2004
81
Selenium deficiency and viral infection. 61
12730444 2003
82
[Coxsackievirus B3 infection and Keshan disease]. 61
12600035 2002
83
HIV-associated cardiomyopathy is not Keshan disease. 61
12042392 2002
84
Multifocal myocardial necrosis: a distinctive cardiac lesion in cystic fibrosis, lipomatous pancreatic atrophy, and Keshan disease. 61
12056507 2002
85
Rationale for clinical trials of selenium as an antioxidant for the treatment of the cardiomyopathy of Friedreich's ataxia. 61
11812188 2002
86
Selenium in soil and endemic diseases in China. 61
11846167 2002
87
Fulminant heart failure due to selenium deficiency cardiomyopathy (Keshan disease). 61
11848134 2002
88
[Keshan disease--a review from the aspect of history and etiology]. 61
11868394 2002
89
Selenite inhibition of Coxsackie virus B5 replication: implications on the etiology of Keshan disease. 61
11878751 2002
90
[Effect of methionine supplementation on the selenium bioavailability in rats fed on grains from Keshan disease endemic area]. 61
11255767 2001
91
Thermal stability of moniliformin at varying temperature, pH, and time in an aqueous environment. 61
11079708 2000
92
Regional ecological risk assessment of selenium in Jilin province, China. 61
11059846 2000
93
Characterization of enterovirus isolates from patients with heart muscle disease in a selenium-deficient area of China. 61
11015360 2000
94
Effects of selenium deficiency on the rat myocardial protein pattern-- investigation by two-dimensional gel electrophoresis. 61
10879621 2000
95
High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China. 61
10814633 2000
96
Selenium supplementation of children in a selenium-deficient area in China: blood selenium levels and glutathione peroxidase activities. 61
11049204 2000
97
[Review on the study of Keshan disease in China]. 61
10682506 1999
98
Selenium. 61
10382553 1999
99
Selenium and viral virulence. 61
10746343 1999
100
Aurothioglucose inhibits murine thioredoxin reductase activity in vivo. 61
9915899 1999
101
Alterations in rat pancreatic islet beta cells induced by Keshan disease pathogenic factors: protective action of selenium and vitamin E. 61
9550538 1998
102
[Protein status and antioxidant capability of residents in endemic and nonendemic areas of Keshan disease(KD)]. 61
10682627 1998
103
[Morphological studies of myocardial fibrosis in different types of Keshan disease]. 61
11244934 1998
104
Vitamin E Status and Neurodegenerative Disease. 61
27406331 1998
105
[Selenium in health and disease]. 61
9789432 1998
106
Changes in myocardial thyroid hormone metabolism and alpha-glycerophosphate dehydrogenase activity in rats deficient in iodine and selenium. 61
9389891 1997
107
Selenium requirements as discussed in the 1996 joint FAO/IAEA/WHO expert consultation on trace elements in human nutrition. 61
9315313 1997
108
Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice. 61
9315324 1997
109
Further investigation on the role of selenium deficiency in the aetiology and pathogenesis of Keshan disease. 61
9315325 1997
110
Interacting nutritional and infectious etiologies of Keshan disease. Insights from coxsackie virus B-induced myocarditis in mice deficient in selenium or vitamin E. 61
9152508 1997
111
Genomic structures of viral agents in relation to the biosynthesis of selenoproteins. 61
9152512 1997
112
[A survey of moniliformin in rice and corn sampled from the areas with and without Keshan disease]. 61
9208523 1996
113
[Effects of selenium and germanium on lipid peroxidation in rats fed with low-selenium grain]. 61
8758855 1996
114
Selenium as a risk factor for cardiovascular diseases. 61
8783029 1996
115
[Trace elements in long-term total parenteral nutrition]. 61
8587186 1996
116
A survey of moniliformin contamination in rice and corn from Keshan disease endemic and non-KSD areas in China. 61
8719174 1995
117
Studies on human dietary requirements and safe range of dietary intakes of selenium in China and their application in the prevention of related endemic diseases. 61
8561918 1995
118
[Effects of selenium and vitamin E on arachidonic acid metabolism in experimental myocardial ischaemia]. 61
8556938 1995
119
[Detection of enteroviral RNA in paraffin-embedded myocardial tissue from patients with Keshan by nested PCR]. 61
7553145 1995
120
[Selenium deficiency and thyroid hormone metabolism and function]. 61
7604216 1995
121
Antioxidant status, erythrocyte fatty acids, and mortality from cardiovascular disease and Keshan disease in China. 61
7956986 1994
122
Selenium deficiency in HIV infection and the acquired immunodeficiency syndrome (AIDS). 61
8194134 1994
123
Benign human enterovirus becomes virulent in selenium-deficient mice. 61
8083665 1994
124
[Studies on the effects of low-dose selenium and high-dose cadmium on myocardial injury]. 61
7924656 1994
125
Factors affecting the selenium intake of people in Transbaikalian Russia. 61
7517165 1994
126
Effects of selenium and alpha-tocopherol on liver damage induced by feeding grains from an endemic area of Keshan disease in rats. 61
7969093 1994
127
Study of a low-selenium environment in China by INAA and Mössbauer spectrometry. 61
7710825 1994
128
Postmortem serum selenium concentrations and their possible etiological role in sudden infant death (SID). 61
8225137 1993
129
[Immunohistochemical studies of islet lesions in Keshan disease patients and rats fed with grains from endemic area of the disease]. 61
8221984 1993
130
Vitamin E requirement of rats fed on a diet containing grains from the endemic region of Keshan disease. 61
8397903 1993
131
[Effects of low calcium on myocardial necrosis of Keshan disease by food preference]. 61
8221983 1993
132
Ultrastructural study of moniliformin induced lesions of myocardium in rats and mice. 61
8476531 1993
133
The epidemiology of selenium deficiency in the etiological study of endemic diseases in China. 61
8427200 1993
134
[Concentration of trace elements in hair from children living in a Keshan disease district in China]. 61
1464948 1992
135
Relationship between dietary fatty acid, selenium, and degenerative cardiomyopathy. 61
1435394 1992
136
A low plasma selenium is a risk factor for peripartum cardiomyopathy. A comparative study in Sahelian Africa. 61
1428253 1992
137
[Keshan disease and the selenium content of grains in Yunnan province]. 61
1606866 1992
138
Fatty acid composition of blood lipids in Chinese children consuming high erucic acid rapeseed oil. 61
1492753 1992
139
Scientific rationale for the 1989 recommended dietary allowance for selenium. 61
1960351 1991
140
Effect of sodium nitrite on myocardial glutathione peroxidase and protective action of vitamin E and selenium. 61
1781932 1991
141
Damage to hepatic thyroxine 5'-deiodination induced by pathogenic factors of Keshan disease and the preventive effects of selenium and vitamin E. 61
1781930 1991
142
Effect of moniliformin on myocardial contractility in rats. 61
1764219 1991
143
[Ultrastructural changes of myocardial biopsy from six children with latent Keshan disease]. 61
1782692 1991
144
[Pharmacokinetics of sodium selenite in human body at different levels of selenium]. 61
1664167 1991
145
Selenium in pediatric nutrition. 61
2000274 1991
146
[Assay of moniliformin content in household grains from families in patients with Keshan disease]. 61
1850646 1991
147
The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million. 61
2096847 1990
148
[Ultrastructural study of moniliformin-induced lesions on the myocardium of rats and mice]. 61
1963352 1990
149
[Protective effects of vitamin E and selenium on myocardial mitochondria in rats--a study on the pathogenic factors and pathogenesis of Keshan disease]. 61
2209265 1990
150
[Study of oxidative damage on mitochondrial membrane of myocardium deficient in selenium]. 61
2167777 1990
151
A study on the inhibition of rat myocardium glutathione peroxidase and glutathione reductase by moniliformin. 61
2366852 1990
152
[Contents of elements in the myocardium in patients with Keshan disease]. 61
2168799 1990
153
Common denominators in the etiology and pathology of visceral lesions of cystic fibrosis and Keshan disease. 61
1702672 1990
154
[Pharmacokinetic study of sodium selenite in low-selenium rabbits]. 61
2177311 1990
155
Selenium and cardiovascular disease. 61
1702669 1990
156
[An insufficiency of essential trace elements and its manifestations in pathology]. 61
2196034 1990
157
[Hyposelenoses]. 61
2128681 1990
158
Reduced cardiac selenium content in the acquired immunodeficiency syndrome. 61
2614866 1989
159
Reversible cardiomyopathy due to selenium deficiency. 61
2614867 1989
160
Biochemical studies of a selenium-deficient population in China: measurement of selenium, glutathione peroxidase and other oxidant defense indices in blood. 61
2795246 1989
161
Pathologic anatomy of the dilated cardiomyopathies. 61
2756900 1989
162
Increased sarcolemmal membrane permeability of cardiac muscle cells in rats fed grains cultivated in a Keshan disease endemic area: a study with horseradish peroxidase as a tracer. 61
2721651 1989
163
[Study on toxicological mechanism of moniliformin]. 61
2800548 1989
164
[Selenium: physiologic role and value in human pathology]. 61
3059285 1988
165
Keshan disease--an endemic mitochondrial cardiomyopathy in China. 61
2908794 1988
166
Keshan disease: an entity or not. 61
3402979 1988
167
[Care of patients with acute Keshan disease]. 61
3197191 1988
168
[Experience in the nursing care of patients with Keshan disease: report of 411 cases]. 61
3197190 1988
169
Selenium: geochemical distribution and associations with human heart and cancer death rates and longevity in China and the United States. 61
2484511 1988
170
Selenium in total parenteral nutrition. 61
2484513 1988
171
Selenite metabolism in rat and human blood. 61
2484530 1988
172
[Keshan disease--a kind of "mitochondrial cardiomyopathy"]. 61
2834901 1987
173
Pancreatic lesions of Keshan disease and its significances. 61
3129250 1987
174
Report on the 1986 A.S.P.E.N. Research Workshop on selenium in clinical nutrition. 61
3098995 1986
175
The two faces of selenium-deficiency and toxicity--are similar in animals and man. 61
3527390 1986
176
Selenium and cardiomyopathy (Keshan disease). 61
3776583 1986
177
[Histochemical change in succinyl dehydrogenase activity in the liver of mice fed with a diet from the region endemic for Keshan disease]. 61
4085303 1985
178
Keshan disease: an endemic cardiomyopathy in China. 61
3997137 1985
179
Effect of selenium deficiency on hydroperoxide-induced glutathione release from the isolated perfused rat heart. 61
3998867 1985
180
M-mode echocardiographic features of children with Keshan disease. A preliminary observation of 106 cases. 61
6242288 1984
181
[Keshan disease--endemic myocardial disease]. 61
6518874 1984
182
[Keshan disease (endemic cardiomyopathy)]. 61
6725542 1984
183
The role of selenium in Keshan disease. 61
6507187 1984
184
[The relationship between selenium and etiology of Keshan disease]. 61
6678485 1983
185
[Electron microscopic observations on endomyocardial biopsy specimens from patients with Keshan disease]. 61
6418354 1983
186
Selenium interactions with carcinogens. 61
6416916 1983
187
[A Preliminary study on the immunological pathogenesis of Keshan disease]. 61
6653216 1983
188
Nutritional bio-geochemical etiology of Keshan disease. 61
6416757 1983
189
[Plasma and erythrocyte levels of selenium and lipids in children with Keshan disease and their pathogenic significance]. 61
6628222 1983
190
Endemic selenium intoxication of humans in China. 61
6846228 1983
191
Pathology of Keshan disease. A comprehensive review. 61
6413138 1983
192
Keshan disease-an endemic cardiomyopathy in China. 61
6412443 1983
193
A study of nutritional and bio-geochemical factors in the occurrence and development of Keshan disease. 61
7131711 1982
194
Selenium deficiency and fatal cardiomyopathy in a patient on home parenteral nutrition. 61
6807740 1982
195
[A study of the relationship between distribution of myocardial foci and coronary blood vessels in Keshan disease I. The pathogenesis of peri-vascular foci]. 61
7128439 1982
196
Keshan disease and selenium in China. 61
7075240 1982
197
[Keshan disease in children and its dietary prevention (author's transl]. 61
6800610 1981
198
[Congestive (dilated type) cardiomyopathy and chronic Keshan disease (a roentgeno-pathological corrective study) (author's transl)]. 61
6461517 1981
199
Metabolic and functional defects in selenium deficiency. 61
6118889 1981
200
[Observation on the effects of adding selenium to table salt for prevention of Keshan disease (author's transl)]. 61
7333186 1981
201
[An investigation of the nature and etiology of the myocardial changes in patients with acute Keshan disease (author's transl)]. 61
7318658 1981
202
[Investigations on distributional relationship between Keshan disease and Se feficiency in animals in Shanxi Province (author's transl)]. 61
7307823 1981
203
[Preliminary observations on the echocardiographic features of 84 cases of Keshan disease (author's transl)]. 61
7297262 1980
204
[Studies of mechanocardiography in Keshan disease (author's transl)]. 61
7307944 1980
205
Studies on the relations of selenium and Keshan disease. 61
24272892 1980
206
[Selenium level in the body of susceptibles of Keshan disease (author's transl)]. 61
7227077 1980
207
[The relationship between seasonal prevalence of Keshan disease and hair selenium level of local inhabitants (author's transl)]. 61
7227078 1980
208
[Research on the relation between selenium and Keshan disease (author's transl)]. 61
262817 1979
209
Observations on effect of sodium selenite in prevention of Keshan disease. 61
114371 1979
210
Epidemiologic studies on the etiologic relationship of selenium and Keshan disease. 61
114372 1979
211
On the etiology of Keshan disease: two hypotheses. 61
110554 1979
212
[The difference between whole blood and hair selenium levels of inhabitants in the endemic and nonendemic areas of Keshan disease (author's transl)]. 61
555741 1979
213
[The difference between the urinary selenium excretion of the children in the endemic and non-endemic areas of Keshan disease (author's transl)]. 61
555742 1979
214
The vetosidum in the treatment of Keshan disease. 61
411634 1977
215
PATHOLOGIC CHANGES OF THE CONDUCTION SYSTEM OF THE HEART IN 43 CASES OF KESHAN DISEASE. 61
14191216 1964
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Variations for Keshan Disease

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Expression for Keshan Disease

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Search GEO for disease gene expression data for Keshan Disease.
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Pathways for Keshan Disease

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Pathways related to Keshan Disease according to GeneCards Suite gene sharing:

(showing 8, show less)
# Super pathways Score Top Affiliating Genes
1
Cell adhesion molecules (CAMs) 36
11.71 ICAM1 HLA-DRA HLA-DOA
2
Folate Metabolism 1
Show member pathways
 11.65 TXNRD3 SEPHS2 SELENOW SELENOT SELENOP SELENOK
3
Staphylococcus aureus infection 36
11.42 ICAM1 HLA-DRA HLA-DOA
4
G-protein signaling N-RAS regulation pathway 22
Show member pathways
 11.39 HLA-DRA HLA-DOA
5
Rheumatoid arthritis 36
11.3 ICAM1 HLA-DRA HLA-DOA
6
Selenium Metabolism and Selenoproteins 1
11.27 TXNRD3 SEPHS2 SELENOW SELENOT SELENOP SELENOK
7
Oxidative Stress 1
10.9 GPX3 GPX1
8
Selenocompound metabolism 36
10.55 TXNRD3 SEPHS2
Sources

GO Terms for Keshan Disease

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Cellular components related to Keshan Disease according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 MHC class II protein complex GO:0042613 8.62 HLA-DRA HLA-DOA

Biological processes related to Keshan Disease according to GeneCards Suite gene sharing:

(showing 9, show less)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.83 TXNRD3 SELENOT MSRB1 GPX3 GPX1
2 cell redox homeostasis GO:0045454 9.54 TXNRD3 SELENOT GPX1
3 hydrogen peroxide catabolic process GO:0042744 9.46 GPX3 GPX1
4 response to oxidative stress GO:0006979 9.46 SELENOP SELENOK GPX3 GPX1
5 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.43 ICAM1 GPX1 BMP5
6 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.4 HLA-DRA HLA-DOA
7 selenium compound metabolic process GO:0001887 9.32 SEPHS2 SELENOP
8 response to selenium ion GO:0010269 9.13 SELENOW SELENOP GPX1
9 cellular oxidant detoxification GO:0098869 9.02 TXNRD3 SELENOW SELENOT GPX3 GPX1

Molecular functions related to Keshan Disease according to GeneCards Suite gene sharing:

(showing 6, show less)
# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.65 TXNRD3 SELENOT MSRB1 GPX3 GPX1
2 glutathione peroxidase activity GO:0004602 9.37 GPX3 GPX1
3 MHC class II protein complex binding GO:0023026 9.32 HLA-DRA HLA-DOA
4 MHC class II receptor activity GO:0032395 9.16 HLA-DRA HLA-DOA
5 thioredoxin-disulfide reductase activity GO:0004791 8.96 TXNRD3 SELENOT
6 selenium binding GO:0008430 8.8 SELENOT SELENOP GPX3
Sources

Sources for Keshan Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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