Keshan Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: KSH001 MIFTS: 37	Keshan Disease Categories: Cardiovascular diseases, Metabolic diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Collapse all tables

Sources

Aliases & Classifications for Keshan Disease

MalaCards integrated aliases for Keshan Disease:

Name: Keshan Disease ¹² ⁵³ ¹⁵ ⁷²

Caused by Deficiency of Selenium in the Diet ⁵³

Enlarged Heart and Poor Heart Function ⁵³

Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050083

UMLS ⁷² C0268095

Sources

Summaries for Keshan Disease

Disease Ontology : ¹² A nutritional deficiency that is disease characterized by a cardiomyopathy secondary to selenium deficiency.

MalaCards based summary : Keshan Disease, also known as caused by deficiency of selenium in the diet, is related to atrial standstill 1 and dilated cardiomyopathy. An important gene associated with Keshan Disease is GPX1 (Glutathione Peroxidase 1), and among its related pathways/superpathways are Allograft rejection and Immune response NFAT in immune response. The drugs Selenium and Micronutrients have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and thyroid, and related phenotype is immune system.

Wikipedia : ⁷⁵ Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium... more...

Sources

Related Diseases for Keshan Disease

Diseases related to Keshan Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 18, show less)

#	Related Disease	Score	Top Affiliating Genes
1	atrial standstill 1	10.6
2	dilated cardiomyopathy	10.5
3	progressive familial heart block, type ia	10.4
4	progressive familial heart block, type ib	10.4
5	right bundle branch block	10.4
6	kashin-beck disease	10.3
7	cystic fibrosis	10.2
8	heart disease	10.2
9	congestive heart failure	10.2
10	myocarditis	10.2
11	optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy	10.1
12	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	10.1
13	hypertensive heart disease	10.1
14	vaccinia	10.1
15	myopathy	10.1
16	tremor	10.1
17	hirata disease	9.5	HLA-DQA1 HLA-DOA
18	systemic lupus erythematosus	8.4	ICAM1 HLA-DRA HLA-DQA1 HLA-DOA

Graphical network of the top 20 diseases related to Keshan Disease:

Sources

Symptoms & Phenotypes for Keshan Disease

MGI Mouse Phenotypes related to Keshan Disease:

⁴⁶ (showing 1, show less)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.17	BMP5 BMP7 GPX1 HLA-DOA HLA-DQA1 ICAM1

Sources

Drugs & Therapeutics for Keshan Disease

Drugs for Keshan Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 7, show less)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Selenium

Approved, Investigational, Vet_approved

Phase 3

7782-49-2

Synonyms:

Se(2+)

Se2+

Selanediide

Selen

Selenide

Selenide(2-)

Selenio

Sélénium

Selenium dication

Selenium elemental

Selenium ion (se2+)

Selenium metallicum

Selenium, elemental

Micronutrients

Phase 3

Sodium Selenite

Phase 3

Antioxidants

Phase 3

Protective Agents

Phase 3

Nutrients

Phase 3

Trace Elements

Phase 3

Interventional clinical trials:

(showing 2, show less)

#	Name	Status	NCT ID	Phase	Drugs
1	Selenium Treatment and Chagasic Cardiopathy (STCC): A Prospective Randomized Trial in Patients With Chagas Disease	Recruiting	NCT00875173	Phase 3	Selenium;Placebo (for Selenium)
2	Myocardial Cell Vein Transplantation for Chronic Heart Failure	Not yet recruiting	NCT03759405	Phase 2, Phase 3

Search NIH Clinical Center for Keshan Disease

Sources

Genetic Tests for Keshan Disease

Sources

Anatomical Context for Keshan Disease

MalaCards organs/tissues related to Keshan Disease:

⁴¹

Heart, Liver, Thyroid, Whole Blood, Pancreatic Islet, Cardiac Myocytes

Sources

Publications for Keshan Disease

Articles related to Keshan Disease:

(showing 213, show less)

#	Title	Authors	PMID	Year
1	Citreoviridin induces myocardial apoptosis through PPAR-γ-mTORC2-mediated autophagic pathway and the protective effect of thiamine and selenium. ³⁸	Feng C...Yao X	31419397	2019
2	Selenium (Se) Deficiency After Orthotopic Heart Transplantation (OHT) (P12-056-19). ³⁸	Rothkopf M...Zucker M	31225078	2019
3	A Spatial Ecology Study of Keshan Disease and Hair Selenium. ³⁸	Zhang X...Han S	30167961	2019
4	The Functional Analysis of Selenium-Related Genes and Magnesium-Related Genes in the Gene Expression Profile Microarray in the Peripheral Blood Mononuclear Cells of Keshan Disease. ³⁸	Wang S...Guo X	31165343	2019
5	Efficacy of Long-term Selenium Supplementation in the Treatment of Chronic Keshan Disease with Congestive Heart Failure. ³⁸	Zhu YH...Xu JH	31016516	2019
6	The aggravating effect of selenium deficiency on T-2 toxin-induced damage on primary cardiomyocyte results from a reduction of protective autophagy. ³⁸	Chen X...Huang K	30629952	2019
7	A spatial ecological study of selenoprotein P and Keshan disease. ³⁸	Zhang X...Han S	30466925	2019
8	Environmental Selenium and Human Health: an Update. ³⁸	Vinceti M...Wise LA	30280317	2018
9	Prevention of Keshan Disease by Selenium Supplementation: a Systematic Review and Meta-analysis. ³⁸	Zhou H...Li D	29627894	2018
10	Associations Between Selenium Content in Hair and Kashin-Beck Disease/Keshan Disease in Children in Northwestern China: a Prospective Cohort Study. ³⁸	Liu H...Guo X	28983831	2018
11	Electrochemical Impedance Spectroscopy for Real-Time Detection of Lipid Membrane Damage Based on a Porous Self-Assembly Monolayer Support. ³⁸	Zhang M...Yan J	29786428	2018
12	Network Analysis of Se-and Zn-related Proteins in the Serum Proteomics Expression Profile of the Endemic Dilated Cardiomyopathy Keshan Disease. ³⁸	Wang S...Guo X	28819918	2018
13	Selenium deficiency aggravates T-2 toxin-induced injury of primary neonatal rat cardiomyocytes through ER stress. ³⁸	Xu J...Huang K	29454614	2018
14	Selenium deficiency in subtropical littoral pampas: environmental and dietary aspects. ³⁸	Mirlean N...Vlasova O	28401376	2018
15	miR-2954 Inhibits PI3K Signaling and Induces Autophagy and Apoptosis in Myocardium Selenium Deficiency. ³⁸	Liu Q...Zhang Z	30463056	2018
16	Prediction of co-expression genes and integrative analysis of gene microarray and proteomics profile of Keshan disease. ³⁸	Wang S...Guo X	29321553	2018
17	Serum quantitative proteomic analysis of patients with keshan disease based on iTRAQ labeling technique: A first term study. ³⁸	Sun Y...Jia J	28965596	2017
18	Preliminary quantitative proteomics analysis in chronic and latent Keshan disease by iTRAQ labeling approach. ³⁸	Sun Y...Liu Y	29285290	2017
19	Mitochondrial activity and oxidative stress functions are influenced by the activation of AhR-induced CYP1A1 overexpression in cardiomyocytes. ³⁸	Zhou B...Tan W	28498411	2017
20	Health risk assessment of environmental selenium: Emerging evidence and challenges (Review). ³⁸	Vinceti M...Ferrante M	28339083	2017
21	Roles of Glycoproteins in the Diagnosis and Differential Diagnosis of Chronic and Latent Keshan Disease. ³⁸	Wang S...Guo X	28481304	2017
22	An approach to assessment of Keshan disease elimination at the township level. ³⁸	Li S...Chen F	27821502	2016
23	[Progressive Risks of Latent Keshan Disease: a Long Term Follow-up Study]. ³⁸	Liu X...Zhu YH	27468488	2016
24	Metabolism of arachidonic acid by the cytochrome P450 enzyme in patients with chronic Keshan disease and dilated cardiomyopathy. ³⁸	Zhou B...Tan W	26893848	2016
25	Selenoproteins and cardiovascular stress. ³⁸	Rose AH...Hoffmann PR	25354851	2015
26	Selenium deficiency associated porcine and human cardiomyopathies. ³⁸	Oropeza-Moe M...Bernhoft A	25456335	2015
27	Involvement of caspases and their upstream regulators in myocardial apoptosis in a rat model of selenium deficiency-induced dilated cardiomyopathy. ³⁸	Shan H...Wei J	26004897	2015
28	Biomonitoring Equivalents for selenium. ³⁸	Hays SM...Aylward LL	25068883	2014
29	H558R polymorphism in SCN5A is associated with Keshan disease and QRS prolongation in Keshan disease patients. ³⁸	Jiang S...Li H	25177937	2014
30	Serum biomarkers of Keshan disease assessed using a protein profiling approach based on ClinProt technique. ³⁸	Xiang Y...Ma W	24841853	2014
31	TLR2-ICAM1-Gadd45α axis mediates the epigenetic effect of selenium on DNA methylation and gene expression in Keshan disease. ³⁸	Yang G...Wei J	24811888	2014
32	Keshan disease, selenium deficiency, and the selenoproteome. ³⁸	Loscalzo J	24785212	2014
33	Mercury (Hg) and oxidative stress status in healthy mothers and its effect on birth anthropometric measures. ³⁸	Al-Saleh I...Rabbah A	24332576	2014
34	Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease. ³⁸	He S...Xiang Y	24384427	2014
35	Long-term prognostic value of major and minor ECG abnormalities in latent Keshan disease with suspect chronic Keshan disease. ³⁸	Zhu Y...Wang X	24975014	2014
36	[Comparative study on condition and related factors of Keshan disease and dilated cardiomyopathy in Shandong province]. ³⁸	Wang X...Qu F	24779040	2014
37	Mitochondrial-related gene expression profiles suggest an important role of PGC-1alpha in the compensatory mechanism of endemic dilated cardiomyopathy. ³⁸	He SL...Guo X	23954821	2013
38	The prevalence of Keshan disease in China. ³⁸	Li Q...Wang T	23218571	2013
39	Comparing gene expression profiles of Kashin-Beck and Keshan diseases occurring within the same endemic areas of China. ³⁸	Wang X...Guo X	23729183	2013
40	[Screening of differentially expressed proteins in serum from subjects with Keshan disease by two-dimensional electrophoresis and mass and mass spectrometry]. ³⁸	He S...Xiang Y	23805519	2013
41	[Two-dimensional gel electrophoresis map of serum proteins in patients with chronic Keshan disease]. ³⁸	Sun YX...Lin L	23898519	2013
42	Oxidative stress is involved in the pathogenesis of Keshan disease (an endemic dilated cardiomyopathy) in China. ³⁸	Pei J...Liu Y	24062877	2013
43	Medical geology of arsenic, selenium and thallium in China. ³⁸	Li S...Zheng B	21440288	2012
44	An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). ³⁸	Chen J	22705420	2012
45	Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China. ³⁸	Wei HL...Wang T	22180033	2011
46	Suboptimal selenium supply--a continuing problem in Keshan disease areas in Heilongjiang province. ³⁸	Hou J...Wang H	21253891	2011
47	The effect of DHEA treatment on the oxidative stress and myocardial fibrosis induced by Keshan disease pathogenic factors. ³⁸	Jia C...Ren L	21602037	2011
48	Selenium in human health and disease. ³⁸	Fairweather-Tait SJ...Hurst R	20812787	2011
49	Is selenium deficiency really the cause of Keshan disease? ³⁸	Lei C...Wei J	20574681	2011
50	Characterization and expression of chicken selenoprotein W. ³⁸	Ou BR...Yeh JY	21207117	2011
51	Selenium deficiency contributes to the chronic myocarditis in coxsackievirus-infected mice. ³⁸	Jun EJ...Lee H	21434702	2011
52	Selenium level surveillance for the year 2007 of Keshan disease in endemic areas and analysis on surveillance results between 2003 and 2007. ³⁸	Yang J...Liu C	20180046	2010
53	[Surveys on the conditions of Keshan disease and selenium levels of 15 counties in Shandong Province in 2008]. ³⁸	Xiang Y...Liu Y	20726240	2010
54	[Polymorphisms in the glutathione peroxidase-1 gene associated with increased risk of Keshan disease]. ³⁸	Lei C...Zhu Y	21055077	2010
55	Chronic exposure to cereal mycotoxin likely citreoviridin may be a trigger for Keshan disease mainly through oxidative stress mechanism. ³⁸	Sun S	20034747	2010
56	Heart failure secondary to selenium deficiency, reversible after supplementation. ³⁸	Saliba W...Shaheen W	19059654	2010
57	Soils and geomedicine. ³⁸	Steinnes E	19350398	2009
58	[Surveillance on Keshan disease from 1990 to 2008 in Sichuan province]. ³⁸	Cai W...Chen XF	20193206	2009
59	Circulating adhesion molecules in patients with Keshan disease and their relationship with Coxsackie B virus infection. ³⁸	Li C...Lei C	19399399	2009
60	Effects of Fusarium mycotoxin butenolide on myocardial mitochondria in vitro. ³⁸	Wang YM...Peng SQ	19778250	2009
61	Selenoproteins. ³⁸	Lu J...Holmgren A	18757362	2009
62	Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy. ³⁸	Lei C...Zhu Y	18940188	2009
63	Lipid peroxidation and antioxidant defense impairment in the hearts of chick embryos induced by in ovo exposure to Fusarium mycotoxin butenolide. ³⁸	Wang YM...Peng SQ	18775738	2008
64	[Observation on conditions and related factors of Keshan disease in Shandong province, 1990-2007]. ³⁸	Xiang YZ...Guan SF	19035191	2008
65	Host-pathogen evolution: Implications for the prevention and treatment of malaria, myocardial infarction and AIDS. ³⁸	Foster HD	17590522	2008
66	Toxic effects of Fusarium mycotoxin butenolide on rat myocardium and primary culture of cardiac myocytes. ³⁸	Liu JB...Wang GQ	17603091	2007
67	[Pathological study of unexpected sudden death clustered in family or village in Yunnan province: report of 29 cases of autopsy]. ³⁸	Wang HY...Zeng G	18001532	2007
68	[Dynamic observation on the relationship between the Keshan disease incidence and some element in internal and external environment in Shanxi Province]. ³⁸	Lei Y...Zhu Y	17953208	2007
69	[The study on relation of HLA-DRB1 gene polymorphism to Keshan disease and its association and linkage in the core families]. ³⁸	Wei J...Zhu JH	17285554	2007
70	Selenium. ³⁸	Alexander J	17913229	2007
71	Keshan disease and mitochondrial cardiomyopathy. ³⁸	Fuyu Y	17312989	2006
72	Microarray analysis of selenium-depleted and selenium-supplemented mice. ³⁸	Hooven LA...Whanger PD	16444006	2006
73	[Selenium and cardiovascular disease: selected issues]. ³⁸	Zagrodzki P...Laszczyk P	17199104	2006
74	Arsenic and selenium in human hair: a comparison of five countries with and without arsenicosis. ³⁸	Spallholz JE...Robertson JD	16116245	2005
75	Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. ³⁸	Conrad M...Brielmeier M	15485910	2004
76	Coxsackievirus B3 infection and its mutation in Keshan disease. ³⁸	Ren LQ...Sun F	15484304	2004
77	Assessment of requirements for selenium and adequacy of selenium status: a review. ³⁸	Thomson CD	14985676	2004
78	Geochemical environment and health problems in China. ³⁸	Lin NF...Bian JM	15214616	2004
79	Selenium deficiency and viral infection. ³⁸	Beck MA...Handy J	12730444	2003
80	[Coxsackievirus B3 infection and Keshan disease]. ³⁸	Huang Z...Wu H	12600035	2002
81	HIV-associated cardiomyopathy is not Keshan disease. ³⁸	Barbaro G	12042392	2002
82	Multifocal myocardial necrosis: a distinctive cardiac lesion in cystic fibrosis, lipomatous pancreatic atrophy, and Keshan disease. ³⁸	Nezelof C...Dijoud F	12056507	2002
83	Rationale for clinical trials of selenium as an antioxidant for the treatment of the cardiomyopathy of Friedreich's ataxia. ³⁸	Fryer MJ	11812188	2002
84	Selenium in soil and endemic diseases in China. ³⁸	Tan J...Yang L	11846167	2002
85	Fulminant heart failure due to selenium deficiency cardiomyopathy (Keshan disease). ³⁸	Burke MP...Opeskin K	11848134	2002
86	[Keshan disease--a review from the aspect of history and etiology]. ³⁸	Liu Y...Kondo M	11868394	2002
87	Selenite inhibition of Coxsackie virus B5 replication: implications on the etiology of Keshan disease. ³⁸	Cermelli C...Portolani M	11878751	2002
88	[Effect of methionine supplementation on the selenium bioavailability in rats fed on grains from Keshan disease endemic area]. ³⁸	Tian Y...Xu J	11255767	2001
89	Thermal stability of moniliformin at varying temperature, pH, and time in an aqueous environment. ³⁸	Pineda-Valdes G...Bullerman LB	11079708	2000
90	Characterization of enterovirus isolates from patients with heart muscle disease in a selenium-deficient area of China. ³⁸	Peng T...Zhang H	11015360	2000
91	Regional ecological risk assessment of selenium in Jilin province, China. ³⁸	Baoyan M...Xuelin Z	11059846	2000
92	Effects of selenium deficiency on the rat myocardial protein pattern-- investigation by two-dimensional gel electrophoresis. ³⁸	Regitz-Zagrosek V...Behne D	10879621	2000
93	High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China. ³⁸	Li Y...Zhang H	10814633	2000
94	Selenium supplementation of children in a selenium-deficient area in China: blood selenium levels and glutathione peroxidase activities. ³⁸	Alfthan G...Kong LH	11049204	2000
95	[Review on the study of Keshan disease in China]. ³⁸	Yu W	10682506	1999
96	Selenium. ³⁸	Barceloux DG	10382553	1999
97	Selenium and viral virulence. ³⁸	Levander OA...Beck MA	10746343	1999
98	Aurothioglucose inhibits murine thioredoxin reductase activity in vivo. ³⁸	Smith AD...Levander OA	9915899	1999
99	Alterations in rat pancreatic islet beta cells induced by Keshan disease pathogenic factors: protective action of selenium and vitamin E. ³⁸	Tong WM...Wang F	9550538	1998
100	[Protein status and antioxidant capability of residents in endemic and nonendemic areas of Keshan disease(KD)]. ³⁸	Gu L...Tian Y	10682627	1998
101	[Morphological studies of myocardial fibrosis in different types of Keshan disease]. ³⁸	Li B...Sun B	11244934	1998
102	[Selenium in health and disease]. ³⁸	Inglot AD...Piasecki E	9789432	1998
103	Vitamin E Status and Neurodegenerative Disease. ³⁸	Fryer MJ	27406331	1998
104	Changes in myocardial thyroid hormone metabolism and alpha-glycerophosphate dehydrogenase activity in rats deficient in iodine and selenium. ³⁸	Wu HY...Chen XS	9389891	1997
105	Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice. ³⁸	Beck MA	9315324	1997
106	Selenium requirements as discussed in the 1996 joint FAO/IAEA/WHO expert consultation on trace elements in human nutrition. ³⁸	Levander OA	9315313	1997
107	Further investigation on the role of selenium deficiency in the aetiology and pathogenesis of Keshan disease. ³⁸	Xu GL...Zhang PY	9315325	1997
108	Interacting nutritional and infectious etiologies of Keshan disease. Insights from coxsackie virus B-induced myocarditis in mice deficient in selenium or vitamin E. ³⁸	Levander OA...Beck MA	9152508	1997
109	Genomic structures of viral agents in relation to the biosynthesis of selenoproteins. ³⁸	Taylor EW...Ramanathan CS	9152512	1997
110	[A survey of moniliformin in rice and corn sampled from the areas with and without Keshan disease]. ³⁸	Yu S...Wang Y	9208523	1996
111	[Effects of selenium and germanium on lipid peroxidation in rats fed with low-selenium grain]. ³⁸	Xie W...Yang K	8758855	1996
112	Selenium as a risk factor for cardiovascular diseases. ³⁸	Neve J	8783029	1996
113	[Trace elements in long-term total parenteral nutrition]. ³⁸	Itokawa Y	8587186	1996
114	A survey of moniliformin contamination in rice and corn from Keshan disease endemic and non-KSD areas in China. ³⁸	Yu SR...Liu J	8719174	1995
115	Studies on human dietary requirements and safe range of dietary intakes of selenium in China and their application in the prevention of related endemic diseases. ³⁸	Yang GQ...Xia YM	8561918	1995
116	[Effects of selenium and vitamin E on arachidonic acid metabolism in experimental myocardial ischaemia]. ³⁸	Liu W...Zhang X	8556938	1995
117	[Detection of enteroviral RNA in paraffin-embedded myocardial tissue from patients with Keshan by nested PCR]. ³⁸	Li Y...Chen H	7553145	1995
118	[Selenium deficiency and thyroid hormone metabolism and function]. ³⁸	Wu HY...Chen XS	7604216	1995
119	Antioxidant status, erythrocyte fatty acids, and mortality from cardiovascular disease and Keshan disease in China. ³⁸	Hensrud DD...Parpia B	7956986	1994
120	Selenium deficiency in HIV infection and the acquired immunodeficiency syndrome (AIDS). ³⁸	Dworkin BM	8194134	1994
121	Benign human enterovirus becomes virulent in selenium-deficient mice. ³⁸	Beck MA...Levander OA	8083665	1994
122	[Studies on the effects of low-dose selenium and high-dose cadmium on myocardial injury]. ³⁸	Wang AG...Lu WQ	7924656	1994
123	Factors affecting the selenium intake of people in Transbaikalian Russia. ³⁸	Aro A...Ivanov VN	7517165	1994
124	Effects of selenium and alpha-tocopherol on liver damage induced by feeding grains from an endemic area of Keshan disease in rats. ³⁸	Liu SY...Wang F	7969093	1994
125	Study of a low-selenium environment in China by INAA and Mössbauer spectrometry. ³⁸	Chai C...Mao D	7710825	1994
126	Postmortem serum selenium concentrations and their possible etiological role in sudden infant death (SID). ³⁸	Lemke R...Makropoulos W	8225137	1993
127	Vitamin E requirement of rats fed on a diet containing grains from the endemic region of Keshan disease. ³⁸	Yang Q...Wang F	8397903	1993
128	[Immunohistochemical studies of islet lesions in Keshan disease patients and rats fed with grains from endemic area of the disease]. ³⁸	Zhang GZ	8221984	1993
129	[Effects of low calcium on myocardial necrosis of Keshan disease by food preference]. ³⁸	Ge LY	8221983	1993
130	Ultrastructural study of moniliformin induced lesions of myocardium in rats and mice. ³⁸	Zhao D...Cui Q	8476531	1993
131	The epidemiology of selenium deficiency in the etiological study of endemic diseases in China. ³⁸	Ge K...Yang G	8427200	1993
132	[Concentration of trace elements in hair from children living in a Keshan disease district in China]. ³⁸	Ohta Y...Matsumoto M	1464948	1992
133	Relationship between dietary fatty acid, selenium, and degenerative cardiomyopathy. ³⁸	Bierenbaum ML...Watkins T	1435394	1992
134	A low plasma selenium is a risk factor for peripartum cardiomyopathy. A comparative study in Sahelian Africa. ³⁸	Cenac A...Djibo A	1428253	1992
135	[Keshan disease and the selenium content of grains in Yunnan province]. ³⁸	Zhou K...Yu ZM	1606866	1992
136	Fatty acid composition of blood lipids in Chinese children consuming high erucic acid rapeseed oil. ³⁸	Laryea MD...Lombeck I	1492753	1992
137	Scientific rationale for the 1989 recommended dietary allowance for selenium. ³⁸	Levander OA	1960351	1991
138	Damage to hepatic thyroxine 5'-deiodination induced by pathogenic factors of Keshan disease and the preventive effects of selenium and vitamin E. ³⁸	Liu SY...Wang F	1781930	1991
139	Effect of sodium nitrite on myocardial glutathione peroxidase and protective action of vitamin E and selenium. ³⁸	Yang Q...Wang F	1781932	1991
140	Effect of moniliformin on myocardial contractility in rats. ³⁸	Fan LL...Sun LH	1764219	1991
141	[Ultrastructural changes of myocardial biopsy from six children with latent Keshan disease]. ³⁸	He TD	1782692	1991
142	[Pharmacokinetics of sodium selenite in human body at different levels of selenium]. ³⁸	Guo JA...Dai LM	1664167	1991
143	Selenium in pediatric nutrition. ³⁸	Litov RE...Combs GF	2000274	1991
144	[Assay of moniliformin content in household grains from families in patients with Keshan disease]. ³⁸	Ji Z	1850646	1991
145	The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million. ³⁸	Cheng YY...Qian PC	2096847	1990
146	[Ultrastructural study of moniliformin-induced lesions on the myocardium of rats and mice]. ³⁸	Zhao D	1963352	1990
147	[Protective effects of vitamin E and selenium on myocardial mitochondria in rats--a study on the pathogenic factors and pathogenesis of Keshan disease]. ³⁸	Liu SY	2209265	1990
148	[Study of oxidative damage on mitochondrial membrane of myocardium deficient in selenium]. ³⁸	Li FS	2167777	1990
149	[Contents of elements in the myocardium in patients with Keshan disease]. ³⁸	An R	2168799	1990
150	A study on the inhibition of rat myocardium glutathione peroxidase and glutathione reductase by moniliformin. ³⁸	Chen LY...Yang B	2366852	1990
151	[Pharmacokinetic study of sodium selenite in low-selenium rabbits]. ³⁸	Wang XY...Guo JA	2177311	1990
152	Common denominators in the etiology and pathology of visceral lesions of cystic fibrosis and Keshan disease. ³⁸	Wallach JD...Goddard RF	1702672	1990
153	Selenium and cardiovascular disease. ³⁸	Oster O...Prellwitz W	1702669	1990
154	[An insufficiency of essential trace elements and its manifestations in pathology]. ³⁸	Avtsyn AP	2196034	1990
155	[Hyposelenoses]. ³⁸	Kakturskii LV...Istomin AA	2128681	1990
156	Reduced cardiac selenium content in the acquired immunodeficiency syndrome. ³⁸	Dworkin BM...Rosenthal WS	2614866	1989
157	Reversible cardiomyopathy due to selenium deficiency. ³⁸	Reeves WC...Movahed A	2614867	1989
158	Biochemical studies of a selenium-deficient population in China: measurement of selenium, glutathione peroxidase and other oxidant defense indices in blood. ³⁸	Xia YM...Burk RF	2795246	1989
159	Pathologic anatomy of the dilated cardiomyopathies. ³⁸	Ferrans VJ	2756900	1989
160	Increased sarcolemmal membrane permeability of cardiac muscle cells in rats fed grains cultivated in a Keshan disease endemic area: a study with horseradish peroxidase as a tracer. ³⁸	Li C...Li CK	2721651	1989
161	[Study on toxicological mechanism of moniliformin]. ³⁸	Zhang H...Li JL	2800548	1989
162	[Selenium: physiologic role and value in human pathology]. ³⁸	Dubois F...Belleville F	3059285	1988
163	Keshan disease--an endemic mitochondrial cardiomyopathy in China. ³⁸	Yang FY...Yin YS	2908794	1988
164	Keshan disease: an entity or not. ³⁸	Yu PL	3402979	1988
165	[Care of patients with acute Keshan disease]. ³⁸	Sun GR...Wang SC	3197191	1988
166	[Experience in the nursing care of patients with Keshan disease: report of 411 cases]. ³⁸	Wu DR	3197190	1988
167	Selenium: geochemical distribution and associations with human heart and cancer death rates and longevity in China and the United States. ³⁸	Jackson ML	2484511	1988
168	Selenium in total parenteral nutrition. ³⁸	von Stockhausen HB	2484513	1988
169	Selenite metabolism in rat and human blood. ³⁸	Mas A...Sarkar B	2484530	1988
170	[Keshan disease--a kind of "mitochondrial cardiomyopathy"]. ³⁸	Yang FY...Wo WH	2834901	1987
171	Pancreatic lesions of Keshan disease and its significances. ³⁸	Kang DR...Yang GF	3129250	1987
172	Report on the 1986 A.S.P.E.N. Research Workshop on selenium in clinical nutrition. ³⁸	Levander OA...Burk RF	3098995	1986
173	The two faces of selenium-deficiency and toxicity--are similar in animals and man. ³⁸	Koller LD...Exon JH	3527390	1986
174	Selenium and cardiomyopathy (Keshan disease). ³⁸	Chen X	3776583	1986
175	[Histochemical change in succinyl dehydrogenase activity in the liver of mice fed with a diet from the region endemic for Keshan disease]. ³⁸	Chen NZ...Xu GL	4085303	1985
176	Keshan disease: an endemic cardiomyopathy in China. ³⁸	Li GS...Li C	3997137	1985
177	Effect of selenium deficiency on hydroperoxide-induced glutathione release from the isolated perfused rat heart. ³⁸	Xia YM...Burk RF	3998867	1985
178	M-mode echocardiographic features of children with Keshan disease. A preliminary observation of 106 cases. ³⁸	Tang SC...Zhang J	6242288	1984
179	[Keshan disease--endemic myocardial disease]. ³⁸	Yang DY	6518874	1984
180	[Keshan disease (endemic cardiomyopathy)]. ³⁸	Yu WH	6725542	1984
181	The role of selenium in Keshan disease. ³⁸	Yang GQ...Chen XS	6507187	1984
182	[The relationship between selenium and etiology of Keshan disease]. ³⁸	Yang GQ	6678485	1983
183	[Electron microscopic observations on endomyocardial biopsy specimens from patients with Keshan disease]. ³⁸	Chen JD...Liang LX	6418354	1983
184	Selenium interactions with carcinogens. ³⁸	Whanger PD	6416916	1983
185	[A Preliminary study on the immunological pathogenesis of Keshan disease]. ³⁸	Lan ZJ...Guan WS	6653216	1983
186	Nutritional bio-geochemical etiology of Keshan disease. ³⁸	Su Y...Yu WH	6416757	1983
187	[Plasma and erythrocyte levels of selenium and lipids in children with Keshan disease and their pathogenic significance]. ³⁸	Li FS	6628222	1983
188	Endemic selenium intoxication of humans in China. ³⁸	Yang GQ...Sun SZ	6846228	1983
189	Pathology of Keshan disease. A comprehensive review. ³⁸	Gu BQ	6413138	1983
190	Keshan disease-an endemic cardiomyopathy in China. ³⁸	Ge K...Wang S	6412443	1983
191	A study of nutritional and bio-geochemical factors in the occurrence and development of Keshan disease. ³⁸	Yu WH	7131711	1982
192	Selenium deficiency and fatal cardiomyopathy in a patient on home parenteral nutrition. ³⁸	Fleming CR...Thistle JL	6807740	1982
193	[A study of the relationship between distribution of myocardial foci and coronary blood vessels in Keshan disease I. The pathogenesis of peri-vascular foci]. ³⁸	Zeng XH	7128439	1982
194	Keshan disease and selenium in China. ³⁸		7075240	1982
195	[Keshan disease in children and its dietary prevention (author's transl]. ³⁸	Su Y...Yu WH	6800610	1981
196	[Congestive (dilated type) cardiomyopathy and chronic Keshan disease (a roentgeno-pathological corrective study) (author's transl)]. ³⁸	Wang ZR	6461517	1981
197	Metabolic and functional defects in selenium deficiency. ³⁸	Diplock AT	6118889	1981
198	[Observation on the effects of adding selenium to table salt for prevention of Keshan disease (author's transl)]. ³⁸	Qian PC	7333186	1981
199	[An investigation of the nature and etiology of the myocardial changes in patients with acute Keshan disease (author's transl)]. ³⁸	Li XZ	7318658	1981
200	[Investigations on distributional relationship between Keshan disease and Se feficiency in animals in Shanxi Province (author's transl)]. ³⁸	Xu GL	7307823	1981
201	[Preliminary observations on the echocardiographic features of 84 cases of Keshan disease (author's transl)]. ³⁸	Kang TJ	7297262	1980
202	[Studies of mechanocardiography in Keshan disease (author's transl)]. ³⁸	Xia DY	7307944	1980
203	Studies on the relations of selenium and Keshan disease. ³⁸	Chen X...Ge K	24272892	1980
204	[Selenium level in the body of susceptibles of Keshan disease (author's transl)]. ³⁸	Yang GQ	7227077	1980
205	[The relationship between seasonal prevalence of Keshan disease and hair selenium level of local inhabitants (author's transl)]. ³⁸	Sung SZ	7227078	1980
206	[Research on the relation between selenium and Keshan disease (author's transl)]. ³⁸		262817	1979
207	Observations on effect of sodium selenite in prevention of Keshan disease. ³⁸		114371	1979
208	Epidemiologic studies on the etiologic relationship of selenium and Keshan disease. ³⁸		114372	1979
209	On the etiology of Keshan disease: two hypotheses. ³⁸	Guanqing H	110554	1979
210	[The difference between whole blood and hair selenium levels of inhabitants in the endemic and nonendemic areas of Keshan disease (author's transl)]. ³⁸	Wang GY	555741	1979
211	[The difference between the urinary selenium excretion of the children in the endemic and non-endemic areas of Keshan disease (author's transl)]. ³⁸	Yin TA	555742	1979
212	The vetosidum in the treatment of Keshan disease. ³⁸	Hsia TY	411634	1977
213	PATHOLOGIC CHANGES OF THE CONDUCTION SYSTEM OF THE HEART IN 43 CASES OF KESHAN DISEASE. ³⁸	LU YJ...WANG KL	14191216	1964

Sources

Genes for Keshan Disease

Genes related to Keshan Disease (0 elite genes):

(showing 9, show less)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GPX1	Glutathione Peroxidase 1	Protein Coding	23.32	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	HLA-DOA	Major Histocompatibility Complex, Class II, DO Alpha	Protein Coding	21.48	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	BMP5	Bone Morphogenetic Protein 5	Protein Coding	21.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	20.92	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	TNFSF15	TNF Superfamily Member 15	Protein Coding	20.61	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	SCN5A	Sodium Voltage-Gated Channel Alpha Subunit 5	Protein Coding	20.3	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	BMP7	Bone Morphogenetic Protein 7	Protein Coding	20.04	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	HLA-DQA1	Major Histocompatibility Complex, Class II, DQ Alpha 1	Protein Coding	19.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	19.67	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Keshan Disease

Sources

Expression for Keshan Disease

Search GEO for disease gene expression data for Keshan Disease.

Sources

Pathways for Keshan Disease

Pathways related to Keshan Disease according to GeneCards Suite gene sharing:

(showing 21, show less)

#	Super pathways	Score	Top Affiliating Genes
1	Allograft rejection ³⁷ ¹ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.59	ICAM1 HLA-DRA HLA-DQA1 HLA-DOA
2	Immune response NFAT in immune response ²² Show member pathways Immune response CD28 signaling ²² Immune response ICOS pathway in T-helper cell ²² Immune response T cell receptor signaling pathway ²²	12.33	HLA-DRA HLA-DQA1 HLA-DOA
3	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.3	HLA-DRA HLA-DQA1 HLA-DOA
4	Interferon gamma signaling ⁶⁶ Show member pathways Interferon Signaling ⁶⁶ Regulation of IFNG signaling ⁶⁶	12.23	ICAM1 HLA-DRA HLA-DQA1
5	ICos-ICosL Pathway in T-Helper Cell ⁶⁴ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶⁴ CD28 Signaling in T-Helper Cell ⁶⁴	12.11	HLA-DRA HLA-DQA1 HLA-DOA
6	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	11.99	HLA-DRA HLA-DQA1 HLA-DOA
7	Tuberculosis ³⁷	11.92	HLA-DRA HLA-DQA1 HLA-DOA
8	Human T-cell leukemia virus 1 infection ³⁷	11.9	ICAM1 HLA-DRA HLA-DQA1 HLA-DOA
9	Phagosome ³⁷	11.81	HLA-DRA HLA-DQA1 HLA-DOA
10	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.78	ICAM1 BMP7 BMP5
11	G-protein signaling N-RAS regulation pathway ²² Show member pathways Immune response Antigen presentation by MHC class II ²²	11.66	HLA-DRA HLA-DQA1 HLA-DOA
12	Cell adhesion molecules (CAMs) ³⁷	11.62	ICAM1 HLA-DRA HLA-DQA1 HLA-DOA
13	S-1P Stimulated Signaling ⁶⁴	11.59	HLA-DRA HLA-DQA1 HLA-DOA
14	MHC class II antigen presentation ⁶⁶	11.59	HLA-DRA HLA-DQA1 HLA-DOA
15	Hematopoietic cell lineage ³⁷	11.53	HLA-DRA HLA-DQA1 HLA-DOA
16	CTLA4 Signaling ⁶⁴	11.35	HLA-DRA HLA-DQA1 HLA-DOA
17	T Cell Co-Signaling Pathway: Ligand-Receptor Interactions ⁶⁵	11.34	TNFSF15 HLA-DRA
18	DNA damage_Role of Brca1 and Brca2 in DNA repair ²²	11.29	HLA-DRA HLA-DQA1 HLA-DOA
19	Rheumatoid arthritis ³⁷	11.23	ICAM1 HLA-DRA HLA-DQA1 HLA-DOA
20	Staphylococcus aureus infection ³⁷	10.91	ICAM1 HLA-DRA HLA-DQA1 HLA-DOA
21	Cardiomyocyte Differentiation through BMP Receptors ⁶⁴	10.82	BMP7 BMP5

Sources

GO Terms for Keshan Disease

Cellular components related to Keshan Disease according to GeneCards Suite gene sharing:

(showing 9, show less)

#	Name	GO ID	Score	Top Affiliating Genes
1	lysosome	GO:0005764	9.61	HLA-DRA HLA-DQA1 HLA-DOA
2	lysosomal membrane	GO:0005765	9.5	HLA-DRA HLA-DQA1 HLA-DOA
3	endocytic vesicle membrane	GO:0030666	9.46	HLA-DRA HLA-DQA1
4	ER to Golgi transport vesicle membrane	GO:0012507	9.4	HLA-DRA HLA-DQA1
5	transport vesicle membrane	GO:0030658	9.37	HLA-DRA HLA-DQA1
6	endosome membrane	GO:0010008	9.33	HLA-DRA HLA-DQA1 HLA-DOA
7	clathrin-coated endocytic vesicle membrane	GO:0030669	9.26	HLA-DRA HLA-DQA1
8	integral component of lumenal side of endoplasmic reticulum membrane	GO:0071556	8.96	HLA-DRA HLA-DQA1
9	MHC class II protein complex	GO:0042613	8.8	HLA-DRA HLA-DQA1 HLA-DOA

Biological processes related to Keshan Disease according to GeneCards Suite gene sharing:

(showing 24, show less)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.86	TNFSF15 HLA-DRA HLA-DQA1 HLA-DOA
2	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:0019886	9.67	HLA-DRA HLA-DQA1 HLA-DOA
3	pattern specification process	GO:0007389	9.62	BMP7 BMP5
4	positive regulation of epithelial cell proliferation	GO:0050679	9.61	SCN5A BMP5
5	regulation of MAPK cascade	GO:0043408	9.61	BMP7 BMP5
6	cell development	GO:0048468	9.6	BMP7 BMP5
7	SMAD protein signal transduction	GO:0060395	9.59	BMP7 BMP5
8	odontogenesis of dentin-containing tooth	GO:0042475	9.58	SCN5A BMP7
9	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:0010862	9.58	BMP7 BMP5
10	hindbrain development	GO:0030902	9.57	BMP7 BMP5
11	pharyngeal system development	GO:0060037	9.55	BMP7 BMP5
12	cardiac muscle tissue development	GO:0048738	9.54	BMP7 BMP5
13	interferon-gamma-mediated signaling pathway	GO:0060333	9.54	ICAM1 HLA-DRA HLA-DQA1
14	positive regulation of dendrite development	GO:1900006	9.52	BMP7 BMP5
15	cardiac septum morphogenesis	GO:0060411	9.51	BMP7 BMP5
16	pericardium morphogenesis	GO:0003344	9.48	BMP7 BMP5
17	heart trabecula morphogenesis	GO:0061384	9.46	BMP7 BMP5
18	chorio-allantoic fusion	GO:0060710	9.43	BMP7 BMP5
19	antigen processing and presentation	GO:0019882	9.43	HLA-DRA HLA-DQA1 HLA-DOA
20	endocardial cushion formation	GO:0003272	9.4	BMP7 BMP5
21	neural fold elevation formation	GO:0021502	9.32	BMP7 BMP5
22	allantois development	GO:1905069	9.16	BMP7 BMP5
23	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902042	9.13	ICAM1 GPX1 BMP5
24	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	GO:0002504	8.8	HLA-DRA HLA-DQA1 HLA-DOA

Molecular functions related to Keshan Disease according to GeneCards Suite gene sharing:

(showing 6, show less)

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.43	TNFSF15 BMP7 BMP5
2	transforming growth factor beta receptor binding	GO:0005160	9.37	BMP7 BMP5
3	peptide antigen binding	GO:0042605	9.32	HLA-DRA HLA-DQA1
4	MHC class II protein complex binding	GO:0023026	9.16	HLA-DRA HLA-DOA
5	BMP receptor binding	GO:0070700	8.96	BMP7 BMP5
6	MHC class II receptor activity	GO:0032395	8.8	HLA-DRA HLA-DQA1 HLA-DOA

Sources

Sources for Keshan Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia