Kidney Angiomyolipoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: KDN015 MIFTS: 46	Kidney Angiomyolipoma Categories: Cancer diseases, Nephrological diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Kidney Angiomyolipoma

MalaCards integrated aliases for Kidney Angiomyolipoma:

Name: Kidney Angiomyolipoma ¹² ⁵⁴ ¹⁵ ¹⁷

Renal Angiomyolipoma ¹² ³⁶ ⁶

Angiomyolipoma of Kidney ¹² ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Nephrological diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:8411

KEGG ³⁶ H01691

NCIt ⁵⁰ C3888

SNOMED-CT ⁶⁷ 254921004

EFO ¹⁷ EFO_1000312

UMLS ⁷¹ C0241961

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Summaries for Kidney Angiomyolipoma

KEGG : ³⁶ Renal angiomyolipoma (AML) is one of the most common solid benign renal tumours, composed of fat, smooth muscle, and blood vessels. About 80% of AMLs are sporadic and not associated with any genetic syndrome. Remaining cases are associated with tuberous sclerosis complex (TSC) and sporadic lymphangioleiomyomatosis (LAM). The pathogenesis of TSC is thought to result from mutations in either the TSC1 or TSC2 genes that encode the proteins tuberin and hamartin, respectively. These proteins interact with each other to form heterodimers, whose most important role is inhibition of the mTOR pathway. Loss of inhibition of mTORC1 leads to increased activation of this pathway and the formation of the lesions characteristic of TSC. Sporadic renal AML usually have mutations in TSC2, but not TSC1.

MalaCards based summary : Kidney Angiomyolipoma, also known as renal angiomyolipoma, is related to lymphangioleiomyomatosis and subependymal giant cell astrocytoma. An important gene associated with Kidney Angiomyolipoma is TSC1 (TSC Complex Subunit 1), and among its related pathways/superpathways are mTOR signaling pathway and Signaling by GPCR. The drugs Everolimus and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include kidney, smooth muscle and lymph node, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Kidney Angiomyolipoma

Diseases related to Kidney Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)

#	Related Disease	Score	Top Affiliating Genes
1	lymphangioleiomyomatosis	30.3	VEGFD TSC2 TSC1 RPS6KB1 RPS6 MTOR
2	subependymal giant cell astrocytoma	30.2	TSC2 TSC1 RHEB MTOR FKBP1A
3	angiomyolipoma	30.2	VEGFD TSC2 TSC1 TFE3 MTOR MLANA
4	perivascular epithelioid cell tumor	30.1	TSC2 TFE3 MLANA
5	congenital heart defects, hamartomas of tongue, and polysyndactyly	30.1	TSC2 TSC1 FLCN
6	pneumothorax, primary spontaneous	30.0	FNIP1 FLCN
7	angiolipoma	30.0	TSC2 MLANA FLCN
8	hepatic angiomyolipoma	29.9	TSC2 TFE3 MTOR MLANA
9	cystic kidney disease	29.8	TSC2 TSC1 MTOR
10	obstructive hydrocephalus	29.7	TSC2 TSC1
11	birt-hogg-dube syndrome	29.1	TSC2 TFE3 MTOR FNIP1 FLCN
12	renal cell carcinoma, nonpapillary	28.7	VEGFD TSC2 TSC1 TFE3 RHEB MTOR
13	tuberous sclerosis	27.5	TSC2 TSC1 TBC1D7 RPTOR RPS6KB1 RPS6
14	tuberous sclerosis 1	27.1	TSC2 TSC1 TBC1D7 RPTOR RPS6KB1 RPS6
15	childhood kidney angiomyolipoma	11.4
16	double uterus-hemivagina-renal agenesis	11.2
17	liposarcoma	10.4
18	pulmonary embolism	10.4
19	uterus bicornis bicollis with partial vaginal septum and unilateral hematocolpos with ipsilateral renal agenesis	10.4
20	ciliary body cancer	10.3	VEGFD MLANA
21	glioma susceptibility 1	10.3
22	pneumothorax	10.3
23	malignant astrocytoma	10.3
24	lissencephaly with cerebellar hypoplasia	10.3	TSC2 TSC1
25	aneurysm	10.2
26	combined hepatocellular carcinoma and cholangiocarcinoma	10.2	MTOR EIF4EBP1
27	oncocytoma	10.2
28	leiomyoma	10.2
29	heart cancer	10.2	TSC2 TSC1 MTOR
30	exudative vitreoretinopathy 6	10.2	MTOR FKBP1A
31	corneal dystrophy, fleck	10.2	TSC2 TSC1 MTOR
32	scalp-ear-nipple syndrome	10.2	TSC2 TSC1 TBC1D7
33	thrombosis	10.2
34	kidney cancer	10.2
35	clear cell renal cell carcinoma	10.2
36	stomatitis	10.2
37	retroperitoneal liposarcoma	10.2
38	polycystic liver disease 1 with or without kidney cysts	10.1	TSC2 TSC1 FLCN
39	skin amelanotic melanoma	10.1	RPS6KB1 EIF4EBP1
40	focal epilepsy	10.1	TSC2 TSC1 MTOR
41	pervasive developmental disorder	10.1	TSC2 TSC1 MTOR
42	polycystic kidney disease	10.1
43	urinary tract infection	10.1
44	leiomyosarcoma	10.1
45	renal oncocytoma	10.1
46	syncope	10.1
47	aortic disease	10.1	TSC2 TSC1 RPS6KB1
48	focal cortical dysplasia, type ii	10.1	TSC2 TSC1 RHEB MTOR
49	familial renal oncocytoma	10.1	FNIP1 FLCN
50	central nervous system benign neoplasm	10.1	TSC2 TSC1 RHEB MTOR

Graphical network of the top 20 diseases related to Kidney Angiomyolipoma:

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Symptoms & Phenotypes for Kidney Angiomyolipoma

GenomeRNAi Phenotypes related to Kidney Angiomyolipoma according to GeneCards Suite gene sharing:

²⁶ (show all 18)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-11	9.96	MTOR RHEB
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-117	9.96	TSC1
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-16	9.96	MTOR RHEB
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-169	9.96	RICTOR
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-173	9.96	MTOR RHEB
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-203	9.96	TSC1
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-206	9.96	TSC1
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-216	9.96	RHEB
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-33	9.96	TSC1
10	Decreased shRNA abundance (Z-score < -2)	GR00366-A-42	9.96	MTOR RHEB RICTOR
11	Decreased shRNA abundance (Z-score < -2)	GR00366-A-53	9.96	MTOR
12	Decreased shRNA abundance (Z-score < -2)	GR00366-A-57	9.96	RHEB
13	Decreased shRNA abundance (Z-score < -2)	GR00366-A-66	9.96	RHEB
14	Decreased shRNA abundance (Z-score < -2)	GR00366-A-73	9.96	MTOR
15	Decreased shRNA abundance (Z-score < -2)	GR00366-A-82	9.96	TSC1
16	Decreased viability with paclitaxel	GR00179-A-1	9.02	MTOR RPS6KB1
17	Decreased viability with paclitaxel	GR00179-A-2	9.02	MTOR
18	Decreased viability with paclitaxel	GR00179-A-3	9.02	MTOR RPS6KB1

MGI Mouse Phenotypes related to Kidney Angiomyolipoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.26	EIF4EBP1 FKBP1A FLCN FNIP1 MLST8 MTOR
2	cellular	MP:0005384	10.23	EIF4EBP1 FKBP1A FLCN FNIP1 MTOR RHEB
3	growth/size/body region	MP:0005378	10.21	EIF4EBP1 FKBP1A FLCN MLST8 MTOR RHEB
4	embryo	MP:0005380	10.13	FKBP1A FLCN MLST8 MTOR RHEB RICTOR
5	homeostasis/metabolism	MP:0005376	10.13	EIF4EBP1 FKBP1A FLCN FNIP1 MTOR RHEB
6	endocrine/exocrine gland	MP:0005379	10.01	MTOR RHEB RICTOR RPS6 RPS6KB1 RPTOR
7	mortality/aging	MP:0010768	10	EIF4EBP1 FKBP1A FLCN FNIP1 MLST8 MTOR
8	liver/biliary system	MP:0005370	9.8	FKBP1A FNIP1 RICTOR RPS6 RPTOR TSC1
9	muscle	MP:0005369	9.61	EIF4EBP1 FKBP1A FNIP1 MTOR RHEB RICTOR
10	neoplasm	MP:0002006	9.17	FLCN FNIP1 RICTOR RPS6KB1 TSC1 TSC2

Sources

Drugs & Therapeutics for Kidney Angiomyolipoma

Drugs for Kidney Angiomyolipoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Everolimus

Approved

Phase 4

159351-69-6

6442177 70789204

Synonyms:

(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone

(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone

(1R,9S,12S,15R,16E,23S,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriacont

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34as)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethy

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

001, RAD

07741_FLUKA

159351-69-6

40-O-(2-hydroxyethyl)-rapamycin

40-O-(2-Hydroxyethyl)-rapamycin

42-O-(2-Hydroxyethyl)rapamycin

Afinitor

Certican

CERTICAN(R)

CHEMBL1201755

D02714

DB01590

everolimus

Everolimus

évérolimus

Everolimus (JAN/USAN/INN)

Everolimus [USAN]

LS-143292

MolPort-003-847-342

MolPort-003-925-588

NCGC00167512-01

NVP-RAD-001

RAD 001

RAD, SDZ

RAD001

RAD-001

RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus

RAD-001C

S1120_Selleck

SDZ RAD

SDZ-RAD

UNII-9HW64Q8G6G

Zortress

Immunologic Factors

Phase 4

Immunosuppressive Agents

Phase 4

Sirolimus

Approved, Investigational

Phase 2

53123-88-9

5284616 6436030

Synonyms:

(-)-rapamycin

(-)-Rapamycin

(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone

1fkb

1pbk

23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine

23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine

23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29

3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

53123-88-9

A422989, NSC226080

AC1L1JH9

AC1L7MJ9

AC1L9ZMV

AC-722

Ambotz53123-88-9

Antibiotic ay 22989

Antibiotic AY 22989

AY 22989

AY22989

AY-22989

BIDD:PXR0165

Bio1_000293

Bio1_000782

Bio1_001271

Bio2_000375

Bio2_000855

BiomolKI2_000084

C07909

C51H79NO13

CBiol_002007

CCRIS 9024

CHEBI:100923

CHEBI:9168

CHEMBL413

CID10213190

CID10795871

CID11949238

CID11959112

CID313006

CID478951

CID5040

CID5284616

CID5358081

CID5374464

CID5460439

CID5497196

CID5924240

CID6436030

CID6610270

CID6610346

CID6711160

CID6713081

CID9833581

CID9854379

CID9854380

CID9962926

CID9962928

D00753

DB00877

DE-109

DivK1c_006936

FT-0082351

heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy

HMS2089A21

HSDB 7284

KBio1_001880

KBio2_000410

KBio2_002978

KBio2_005546

KBio3_000779

KBio3_000780

KBioGR_000410

KBioSS_000410

LCP-Siro

LMPK06000003

LS-143290

MLS000028373

MolMap_000043

MolPort-003-959-433

MS-R001

NCGC00021305-05

nchembio.100-comp4

nchembio.2007.42-comp2

nchembio.79-comp1

nchembio762-comp1

nchembio883-comp3

NCI60_001851

NCIMech_000355

NSC 226080

NSC226080

Perceiva

QTL1_000069

R0395_SIAL

R0395_SIGMA

RAP

RAPA

Rapammune

Rapamune

Rapamune (TN)

rapamycin

Rapamycin

Rapamycin (TN)

Rapamycin C-7, analog 4

Rapamycin from Streptomyces hygroscopicus

Rapamycin Immunosuppressant Drug

Rapamysin

RPM

S1039_Selleck

SIIA 9268A

SILA 9268A

SILA9268A

sirolimus

Sirolimus

Sirolimús

Sirolimus (RAPAMUNE)

Sirolimus (USAN/INN)

Sirolimus [USAN:BAN:INN]

Sirolimus, Rapamune,Rapamycin

Sirolimusum

SMP1_000255

SMR000058564

SpecPlus_000840

UNII-W36ZG6FT64

UNM-0000358684

Wy 090217

WY-090217

Clotrimazole

Approved, Vet_approved

Phase 2

23593-75-1

2812

Synonyms:

(Chlorotrityl)imidazole

1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole

1-(a-(2-Chlorophenyl)benzhydryl)imidazole

1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole

1-(O-Chloro-a,a-diphenylbenzyl)imidazole

1-(O-Chloro-alpha,alpha-diphenylbenzyl)imidazole

1-(o-Chlorotrityl)imidazole

1-(O-Chlorotrityl)imidazole

1-(o-Chloro-α,α-diphenylbenzyl)imidazole

1-(O-Chloro-α,α-diphenylbenzyl)imidazole

1-(α-(2-Chlorophenyl)benzhydryl)imidazole

1-(Α-(2-chlorophenyl)benzhydryl)imidazole

117829-71-7

23593-75-1

33894_FLUKA

33894_RIEDEL

3ACDFDF8-38E3-4368-85D0-BDF8AE1E6591

AB00051951

AC1L1EIW

AC-279

B 5097

BAY 5097

Bay b 5097

BAY b 5097

Bay b 9057

BAY b5097

BAY-5097

Bay-B 5097

BAYb 5097

Bayer brand 1 OF clotrimazole

Bayer Brand 1 of Clotrimazole

Bayer brand 2 OF clotrimazole

Bayer Brand 2 of Clotrimazole

BIDD:GT0450

BIDD:PXR0036

Bio-0442

BPBio1_000126

BRN 0622318

BSPBio_000114

BSPBio_002057

C 6019

C06922

C22H17ClN2

C6019_SIGMA

Canesten

Canesten 1-day cream combi-pak

Canesten 1-Day Cream Combi-Pak

Canesten 1-day therapy

Canesten 1-Day Therapy

Canesten 3-day therapy

Canesten 3-Day Therapy

Canesten 6-day therapy

Canesten 6-Day Therapy

Canesten combi-pak 1-day therapy

Canesten Combi-Pak 1-Day Therapy

Canesten combi-pak 3-day therapy

Canesten Combi-Pak 3-Day Therapy

Canesten cream

Canesten Cream

Canesten solution

Canesten Solution

Canestene

Canestine

Canifug

CAS-23593-75-1

CCRIS 6245

CHEBI:3764

CHEMBL104

Chlotrimazole

CID2812

Cimitidine

Clomatin

Clotrimaderm

Clotrimaderm cream

Clotrimazol

Clotrimazol [INN-Spanish]

clotrimazole

Clotrimazole

Clotrimazole (JP15/USP/INN)

Clotrimazole [USAN:INN:BAN:JAN]

Clotrimazole schering brand

Clotrimazole Schering Brand

Clotrimazolum

Clotrimazolum [INN-Latin]

clotrimeizol

CPD000058306

CPD-8926

Cutistad

D00282

D003022

DB00257

Desamix F

DivK1c_000665

DRG-0072

EINECS 245-764-8

Empecid

Esparol

EU-0100315

FB 5097

FB b 5097

Fem care

Fem Care

FemCare

Gino-Lotremine

Gyne lotrimin

Gyne-lotrimin

Gyne-Lotrimin

Gyne-lotrimin 3

Gyne-Lotrimin 3

Gyne-lotrimin 3 combination pack

Gyne-Lotrimin 3 Combination Pack

Gyne-lotrimin combination pack

Gyne-Lotrimin Combination Pack

Gyne-lotrimin3

Gyne-lotrimin3 combination pack

Gynix

HMS1568F16

HMS1920O21

HMS2051E11

HMS2091G10

HMS502B07

HSDB 3266

I01-3474

IDI1_000665

Kanesten

KBio1_000665

KBio2_001823

KBio2_004391

KBio2_006959

KBio3_001277

KBioGR_000850

KBioSS_001823

Klotrimazole

Lopac0_000315

Lopac-C-6019

Lotrimax

Lotrimin

Lotrimin (TN)

Lotrimin af

Lotrimin Af

Lotrimin af cream

Lotrimin AF Cream

Lotrimin af jock-itch cream

Lotrimin AF Jock-Itch Cream

Lotrimin af lotion

Lotrimin AF Lotion

Lotrimin af solution

Lotrimin AF Solution

Lotrimin cream

Lotrimin Cream

Lotrimin lotion

Lotrimin Lotion

Lotrimin solution

Lotrimin Solution

Lotrisone

LS-78271

MLS000028502

MLS000758243

MLS001423972

MolPort-002-557-756

mono-Baycuten

Monobaycuten

Mono-baycuten

Mycelax

Mycelex

Mycelex (TN)

Mycelex 7

Mycelex cream

Mycelex Cream

Mycelex g

Mycelex G

Mycelex otc

Mycelex OTC

Mycelex solution

Mycelex Solution

Mycelex troches

Mycelex Troches

Mycelex twin pack

Mycelex Twin Pack

Mycelex: mycosporinrimazole

Mycelex: MycosporinRimazole

Mycelex-7

Mycelex-7 combination pack

Mycelex-7 Combination Pack

Mycelex-g

Mycelex-G

Myclo cream

Myclo Cream

Myclo solution

Myclo Solution

Myclo spray solution

Myclo Spray Solution

Myclo-gyne

Myclo-Gyne

Mycofug

Mycosporin

Mykosporin

Nalbix

NCGC00015251-01

NCGC00015251-02

NCGC00015251-03

NCGC00015251-09

NCGC00093761-01

NCGC00093761-02

NCGC00093761-03

NCGC00093761-04

NCGC00093761-05

NCGC00093761-06

nchembio.65-comp9

nchembio790-comp30

NCIMech_000609

Neo-zol cream

Neo-Zol Cream

NINDS_000665

NSC 257473

NSC257473

Otomax

Pan-Fungex

Pedisafe

Prestwick_120

Prestwick0_000267

Prestwick1_000267

Prestwick2_000267

Prestwick3_000267

QTL1_000024

Rimazole

S1606_Selleck

SAM001247056

Schering brand OF clotrimazole

Schering Brand of Clotrimazole

SMR000058306

SPBio_000176

SPBio_002333

Spectrum_001343

SPECTRUM1500200

Spectrum2_000128

Spectrum3_000359

Spectrum4_000295

Spectrum5_000781

Stiemazol

STK700023

Tibatin

Trimysten

Trivagizole 3

UNII-G07GZ97H65

Veltrim

ZINC03807804

Miconazole

Approved, Investigational, Vet_approved

Phase 2

22916-47-8

4189

Synonyms:

(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole

1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole

1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole

1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole

1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole

1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole

1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole

1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole

1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole

22832-87-7 (NITRATE)

22916-47-8

75319-47-0

AB00053500

AC1L1HM1

Aflorix(nitrate)

AKOS001574474

Albistat(nitrate)

Andergin(nitrate)

BPBio1_000279

BRD-A82396632-001-03-0

BRD-A82396632-008-02-7

Brentan

BRN 0965511

BSPBio_000253

BSPBio_002033

CCRIS 7924

CHEBI:6923

CHEMBL91

CID4189

Conofite(nitrate)

CPD-4501

D00416

Dactarin

Daktarin IV

DB01110

DivK1c_000156

EINECS 245-324-5

Epi-Monistat(nitrate)

Esteve brand OF miconazole

Femizol-M

Florid(nitrate)

Gyno-Daktar(nitrate)

HMS1568M15

HMS2090B21

I14-14342

IDI1_000156

imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)

Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)

Janssen cilag brand OF miconazole

Janssen-cilag brand OF miconazole

Johnston and johnston brand OF miconazole nitrate

KBio1_000156

KBio2_001445

KBio2_004013

KBio2_006581

KBio3_001533

KBioGR_000581

KBioSS_001445

Lotrimin AF(nitrate)

LS-78378

MCZ

Micantin (nitrate)

Miconasil nitrate

Miconasil Nitrate

Miconazol

Miconazol [INN-Spanish]

miconazole

Miconazole

Miconazole (JP15/USP/INN)

Miconazole [USAN:BAN:INN:JAN]

Miconazole 3

Miconazole 3 Combination Pack

Miconazole 7 Combination Pack

Miconazole esteve brand

Miconazole janssen-cilag brand

Miconazole nitrate

Miconazole nitrate salt

Miconazole-7

Miconazolo

Miconazolo [DCIT]

Miconazolum

Miconazolum [INN-Latin]

Micozole

Minostate

MJR 1762

MLS002222203

MolPort-002-557-553

Monazole 7

Monista (nitrate)

Monistat

Monistat (TN)

Monistat 1 Combination Pack

Monistat 3 Dual-Pak

Monistat 3 Vaginal Ovules

Monistat 5 Tampon

Monistat 7 Dual-Pak

Monistat 7 Vaginal Suppositories

Monistat Dual- PAK

Monistat IV

Monistat iv (TN)

Monistat-Derm

NCI60_001353

NCI60_001380

NINDS_000156

Nitrate, miconasil

Nitrate, miconazole

Novo-Miconazole Vaginal Ovules

NSC 170986

NSC169434

NSC170986

Oprea1_091955

Prestwick_335

Prestwick0_000067

Prestwick1_000067

Prestwick2_000067

Prestwick3_000067

R 18134

R-14,889

SMR001307249

SPBio_000976

SPBio_002174

Spectrum_000965

Spectrum2_001048

Spectrum3_000507

Spectrum4_000061

Spectrum5_001297

STK834405

STOCK1S-93556

UNII-7NNO0D7S5M

Vusion

Zimycan

Propranolol

Approved, Investigational

Phase 2

525-66-6

4946

Synonyms:

(+-)-Propranolol

(1)-1-(Isopropylamino)-3-(naphthyloxy)propan-2-ol

(R)-(+)-propranolol

(S)-(-)-PROPRANOLOL

1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol

1-(1-Naphthyloxy)-2-hydroxy-3-(isopropylamino)propane

1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol

1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol

1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol

1-(Isopropylamino)-3-(1-naphthyloxy)propan-2-ol

1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol

1-[(1-methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol

13013-17-7

1-Isopropylamino-3-(1-naphthyloxy)-2-propanol

1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol

2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- (9CI)

2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)- (9CI)

3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol

4199-09-1

4199-10-4

525-66-6

AB00053537

AC1L1JA4

AC1Q1QBV

AC1Q1QC0

AKOS000588816

Anaprilin

Anapriline

Angilol

Apsolol

Avlocardyl

AY 64043

AY-20694

Bedranol

Beprane

Berkolol

Beta Neg

Betachron

Betadren

Betalong

Beta-Neg

beta-Propranolol

Beta-Propranolol

Beta-Tablinen

Beta-Timelets

Bio-0732

Bio1_000367

Bio1_000856

Bio1_001345

BPBio1_001040

b-Propranolol

BRD-A10070317-003-06-9

BSPBio_000944

BSPBio_002682

C07407

C16H21NO2

Cardinol

Caridolol

CBDivE_006180

CCRIS 3082

CHEBI:8499

CHEMBL27

CID4946

cMAP_000071

Corpendol

D,L-Propranolol

D08443

DB00571

Deralin

Dexpropranolol

DivK1c_000023

Dl-Propranolol Hydrochloride

DL-Propranolol hydrochloride

Dociton

Duranol

Efektolol

EINECS 208-378-0

EINECS 235-867-6

Elbrol

etalong

Etalong

Euprovasin

Frekven

Herzbase

HMS2090L21

Hydrochloride, propranolol

ICI 45520

IDI1_000023

Ikopal

Inderal

Inderal hydrochloride

Inderal La

Inderalici

Inderex

Inderide

INDERIDE-40/25

INDERIDE-80/25

Inderol

Indobloc

Innopran XL

InnoPranXL

Intermigran

KBio1_000023

KBio2_002515

KBio2_005083

KBio2_007651

KBio3_001766

KBio3_001902

KBio3_002993

KBioGR_001347

KBioGR_001684

KBioGR_002515

KBioSS_002523

Kemi

Kemi S

L000679

Lopac0_000896

LS-122410

LS-184129

Migrastat

MolPort-001-794-623

Naprilin

NCGC00015798-07

NCGC00024690-02

NCGC00024690-03

NINDS_000023

NSC91523

Obsidan

Obzidan

Oposim

Oprea1_304193

PDSP1_000767

PDSP1_001607

PDSP1_001608

PDSP2_000755

PDSP2_001591

PDSP2_001592

Pranolol

Prano-Puren

Prestwick0_000952

Prestwick1_000952

Prestwick2_000952

Prestwick3_000952

Pronovan

Propanalol

Propanix

Propanolol

Propanolol [INN-Spanish]

Prophylux

Propranalol

propranolol

Propranolol

Propranolol (INN)

Propranolol (TN)

Propranolol [INN:BAN]

Propranolol Hcl

Propranolol Hcl Intensol

Propranolol hydrochloride

Propranolol Hydrochloride

propranololo

Propranololo

Propranololo [DCIT]

Propranololum

Propranololum [INN-Latin]

Propranur

Proprasylyt

Pylapron

R,S-Propranolol Hydrochloride

Racemic propranolol

Rapynogen

Reducor

Reducor line

Reducor Line

Rexigen

Sagittol

Sawatal

Servanolol

Sloprolol

SPBio_001361

SPBio_001658

SPBio_003093

Spectrum2_001301

Spectrum2_001699

Spectrum3_000883

Spectrum3_001071

Spectrum4_000974

Spectrum4_001222

Spectrum5_000751

STK735510

Sumial

Tesnol

UNII-9Y8NXQ24VQ

β-Propranolol

Β-propranolol

Antifungal Agents

Phase 2

Antibiotics, Antitubercular

Phase 2

Anti-Infective Agents

Phase 2

Anti-Bacterial Agents

Phase 2

Adrenergic Antagonists

Phase 2

Angiogenesis Inhibitors

Phase 2

Adrenergic beta-Antagonists

Phase 2

Antihypertensive Agents

Phase 2

Neurotransmitter Agents

Phase 2

Adrenergic Agents

Phase 2

Vasodilator Agents

Phase 2

Anti-Arrhythmia Agents

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase IV, Single Arm Study of Safety and Efficacy of Everolimus in Chinese Adults With Tuberous Sclerosis Complex Who Have Renal Angiomyolipoma Not Requiring Immediate Surgery	Completed	NCT03525834	Phase 4	everolimus
2	A Phase II Multi-Center Study of Rapamycin for Treating Kidney Angiomyolipomas in TSC or LAM Patients	Unknown status	NCT00126672	Phase 2	sirolimus
3	Treatment of Renal Angiomyolipomas in Tuberous Sclerosis by Beta-blockers: Pilot Trial	Completed	NCT02104011	Phase 2	Propranolol
4	Clinical Presentation and Renal Outcome of Patients With Tuberous Sclerosis Complex and/or Renal Angiomyolipoma in the Great West Region of France	Unknown status	NCT02887781

Search NIH Clinical Center for Kidney Angiomyolipoma

Sources

Genetic Tests for Kidney Angiomyolipoma

Sources

Anatomical Context for Kidney Angiomyolipoma

MalaCards organs/tissues related to Kidney Angiomyolipoma:

⁴⁰

Kidney, Smooth Muscle, Lymph Node, Uterus, Colon, Spleen, Adipocyte

Sources

Publications for Kidney Angiomyolipoma

Articles related to Kidney Angiomyolipoma:

(show top 50) (show all 1314)

#	Title	Authors	PMID	Year
1	Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients. ⁵⁴ ⁶¹	Habib SL	19265534	2009
2	Genetic polymorphisms in OGG1 and their association with angiomyolipoma, a benign kidney tumor in patients with tuberous sclerosis. ⁵⁴ ⁶¹	Habib SL...Thameem F	17932460	2008
3	[Tests for loss of heterozygosity in tuberous sclerosis]. ⁶¹ ⁵⁴	Jozwiak S...Grajkowska W	11355103	2001
4	The tuberous sclerosis complex-associated giant renal angiomyolipoma: A case report. ⁶¹	Sun P...He Y	33604042	2021
5	Giant renal pseudoaneurysm complicating angiomyolipoma in a patient with tuberous sclerosis complex: An unusual case report and review of the literature. ⁶¹	Esmat HA...Naseri MW	33520209	2021
6	[Pulmonary lymphangioleiomyomatosis (LAM)]. ⁶¹	Theegarten D...Hager T	33420570	2021
7	Quantitative spectral CT evaluation of kidney tumors with the stretched-exponential nonlinear regression analysis model. ⁶¹	Yang X...Liu Y	33532267	2021
8	Natural growth pattern of sporadic renal angiomyolipoma. ⁶¹	Courtney M...Lee M	32321277	2021
9	Magnetic resonance diffusion kurtosis imaging in differential diagnosis of benign and malignant renal tumors. ⁶¹	Fu J...Zhu Q	33413681	2021
10	MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61. ⁶¹	Zarei M...Kwiatkowski DJ	33082558	2021
11	Efficacy and safety of low-dose everolimus treatment for renal angiomyolipoma associated with tuberous sclerosis complex. ⁶¹	Hatano T...Tamari M	32990779	2021
12	Enhancing disease awareness for tuberous sclerosis complex in patients with radiologic diagnosis of renal angiomyolipoma: an observational study. ⁶¹	Bausch K...Seifert HH	33517888	2021
13	Review of Value of CT Texture Analysis and Machine Learning in Differentiating Fat-Poor Renal Angiomyolipoma from Renal Cell Carcinoma. ⁶¹	Zhang Y...Gu X	33364422	2020
14	Contrast-Enhanced Ultrasound for Assessing Abdominal Conditions in Pregnancy. ⁶¹	Geyer T...Clevert DA	33302381	2020
15	Right renal angiomyolipoma with intracardiac extension and pulmonary embolism. ⁶¹	Wang D...Xie M	33325037	2020
16	[Concurrent low-grade oncocytic renal tumor with CD117 negative/CK7 positive immunophenotype and renal angiomyolipoma]. ⁶¹	Liu YF...Hu YC	33287518	2020
17	Embolization of an angiomyolipoma in a crossed fused renal ectopia. ⁶¹	Tayeb W...Badr H	33102000	2020
18	PNL2: A Useful Adjunct Biomarker to HMB45 in the Diagnosis of Uterine Perivascular Epithelioid Cell Tumor (PEComa). ⁶¹	Valencia-Guerrero A...Hirsch MS	31851063	2020
19	A case of acute bleeding from a small, asymptomatic renal angiomyolipoma (AML) during pneumoperitoneum induction for a rectal tumor resulting in acute hematuria and anemia. ⁶¹	Ripa F...Montanari E	33102117	2020
20	Differential diagnosis of hypervascular ultra-small renal cell carcinoma and renal angiomyolipoma with minimal fat in early stage by using thin-section multidetector computed tomography. ⁶¹	Wang X...Shao G	32415344	2020
21	Multimodality Imaging of Abdominopelvic Tumors with Venous Invasion. ⁶¹	LeGout JD...Alexander LF	33064623	2020
22	Conservative treatment of monolateral giant renal angiomyolipoma in a patient with Tuberous Sclerosis Complex (TSC): A case report. ⁶¹	Ambrosi Grappelli VM...Agro EF	33102110	2020
23	Renal angiomyolipoma with tuberous sclerosis complex: How it differs from sporadic angiomyolipoma in both management and care. ⁶¹	Hatano T...Egawa S	31959574	2020
24	The Efficacy of Everolimus for Facial Angiofibromas in Tuberous Sclerosis Complex Patients Treated for Renal Angiomyolipoma/Subependymal Giant Cell Astrocytoma. ⁶¹	Wei CC...Tsai JD	33032292	2020
25	The Clinical Value and Appropriateness Criteria of Upper Abdominal Magnetic Resonance Examinations in Patients Before and After Bariatric Surgery: a Study of 837 Images. ⁶¹	Lv H...Wang Z	32483745	2020
26	Spontaneous rupture of enormous renal angiomyolipoma in a pregnant tuberous sclerosis patient: a rare case. ⁶¹	Liu Z...Fan Z	33129297	2020
27	Lymphangioleiomyomatosis Presenting as Recurrent Pneumothorax. ⁶¹	Odak M...Rogers PJ	33240698	2020
28	Epithelioid angiomyolipoma with tumor thrombus in IVC and right atrium. ⁶¹	Gupta D...Elhence P	33344317	2020
29	[Prevalence of the tuberous sclerosis complex at patients taken care for a renal angiomyolipoma]. ⁶¹	Maulaz P...Bigot P	32718886	2020
30	Diagnostic value of ultrasound in the spontaneous rupture of renal angiomyolipoma during pregnancy: A case report. ⁶¹	Zhang T...Wang DX	32953867	2020
31	Evidence-based protocol-led management of renal angiomyolipoma: A review of literature. ⁶¹	Vaggers S...Rai BP	32966208	2020
32	Utility of material-specific fat images derived from rapid-kVp-switch dual-energy renal mass CT for diagnosis of renal angiomyolipoma. ⁶¹	Walker D...Schieda N	32957794	2020
33	Renal angiomyolipoma: Clinico-pathologic study of 17 cases with emphasis on the epithelioid histology and p53 gene abnormalities. ⁶¹	Boudaouara O...Sellami Boudawara T	32574890	2020
34	[A Case of Renal Epithelioid Angiomyolipoma with Recurrence in the Abdominal Cavity]. ⁶¹	Fujiwara M...Okumura K	32723978	2020
35	Natural history of incidental sporadic and tuberous sclerosis complex associated lymphangioleiomyomatosis. ⁶¹	Di Marco F...Guedes Baldi B	32469709	2020
36	The efficacy of cannabidiol on renal angiomyolipoma and subependymal giant cell tumor volume in tuberous sclerosis complex. ⁶¹	Barnett JR...Thiele EA	32409220	2020
37	Therapeutic Targeting of the Secreted Lysophospholipase D Autotaxin Suppresses Tuberous Sclerosis Complex-Associated Tumorigenesis. ⁶¹	Feng Y...Priolo C	32393662	2020
38	Natural History of Renal Angiomyolipoma Favors Surveillance as an Initial Approach. ⁶¹	Nason GJ...Finelli A	32636160	2020
39	Fat-poor renal angiomyolipoma combined with pseudoaneurysm: a case report. ⁶¹	Chong J...Sun Y	32527122	2020
40	Late Recurrence of Metastatic Pancreatic Angiomyolipoma in Tuberous Sclerosis Following Bilateral Nephrectomy and Transplant. ⁶¹	Sinha A...Khara HS	33062782	2020
41	Exploring serum metabolic markers for the discrimination of ccRCC from renal angiomyolipoma by metabolomics. ⁶¹	Xiang M...Xie B	32613842	2020
42	Spontaneous rupture of large bilateral renal angiomyolipomas in a patient with tuberous sclerosis complex: A case report and literature review. ⁶¹	Ben Mansoura W...Mizouni H	32025496	2020
43	Fate of Pediatric Renal Angiomyolipoma During mTOR Inhibitor Treatment in Tuberous Sclerosis Complex. ⁶¹	Wu CQ...Smith EA	32081671	2020
44	A scoring system based on clinical features for the prediction of sporadic renal angiomyolipoma rupture and hemorrhage. ⁶¹	Xu XF...Zhang Y	32443333	2020
45	Simultaneous totally robotic rectal resection and partial nephrectomy: case report and review of literature. ⁶¹	Cochetti G...Mearini E	32366262	2020
46	Notch sign in renal angiomyolipoma. ⁶¹	Milosevic S...Djuric-Stefanovic A	31970438	2020
47	Surgical management of angiomyolipoma with vena cava thrombus during pregnancy: a case report. ⁶¹	Zhang Z...He Z	32420188	2020
48	A large bi-lobed classic renal angiomyolipoma with vena caval extension. ⁶¹	Abou Heidar NF...Abi Saad G	32055259	2020
49	Sporadic giant renal angiomyolipoma: A case report and literature review of clinical presentation, diagnosis, and treatment options. ⁶¹	Alshehri M...Raheem AA	32565656	2020
50	Renal angiomyolipoma (AML) harboring a missense mutation of TSC2 with copy-neutral loss of heterozygosity (CN-LOH). ⁶¹	Idogawa M...Natori H	31847710	2020

Sources

Genes for Kidney Angiomyolipoma

Genes related to Kidney Angiomyolipoma (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	TSC1	TSC Complex Subunit 1	Protein Coding	19.04	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	17932460 11355103 19265534
2	TSC2	TSC Complex Subunit 2	Protein Coding	19	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	12192641 11355103 19005330 (more) 19265534
3	VEGFD	Vascular Endothelial Growth Factor D	Protein Coding	13.9	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	7.95	DISEASES inferred ¹⁵
5	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	7.38	DISEASES inferred ¹⁵
6	MLANA	Melan-A	Protein Coding	6.93	DISEASES inferred ¹⁵
7	TBC1D7	TBC1 Domain Family Member 7	Protein Coding	6.47	DISEASES inferred ¹⁵
8	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	6.43	DISEASES inferred ¹⁵
9	FLCN	Folliculin	Protein Coding	6.37	DISEASES inferred ¹⁵
10	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	6.18	DISEASES inferred ¹⁵
11	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	6.16	DISEASES inferred ¹⁵
12	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	5.93	DISEASES inferred ¹⁵
13	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	5.91	DISEASES inferred ¹⁵
14	MLST8	MTOR Associated Protein, LST8 Homolog	Protein Coding	5.83	DISEASES inferred ¹⁵
15	TFE3	Transcription Factor Binding To IGHM Enhancer 3	Protein Coding	5.79	DISEASES inferred ¹⁵
16	RPS6	Ribosomal Protein S6	Protein Coding	5.65	DISEASES inferred ¹⁵
17	FNIP1	Folliculin Interacting Protein 1	Protein Coding	5.64	DISEASES inferred ¹⁵

Sources

Variations for Kidney Angiomyolipoma

ClinVar genetic disease variations for Kidney Angiomyolipoma:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	TSC1	NM_000368.4(TSC1):c.359T>C (p.Leu120Pro)	SNV	Uncertain significance	523362	rs1554820262	9:135800978-135800978	9:132925591-132925591

Sources

Expression for Kidney Angiomyolipoma

Search GEO for disease gene expression data for Kidney Angiomyolipoma.

Sources

Pathways for Kidney Angiomyolipoma

Pathways related to Kidney Angiomyolipoma according to KEGG:

³⁶

#	Name	Kegg Source Accession
1	mTOR signaling pathway	hsa04150

Pathways related to Kidney Angiomyolipoma according to GeneCards Suite gene sharing:

(show top 50) (show all 61)

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁵ Show member pathways GPCR downstream signaling ⁶⁵ Signal Transduction ⁶⁵	14.17	VEGFD TSC2 TSC1 RPTOR RPS6KB1 RPS6
2	Gene Expression ⁶⁵ Show member pathways Generic Transcription Pathway ⁶⁵	13.8	TSC2 TSC1 RPTOR RPS6 RICTOR RHEB
3	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. ⁶⁵ Show member pathways Complex I biogenesis ⁶⁵ Electron Transport Chain ¹ Formation of ATP by chemiosmotic coupling ⁶⁵ Non-alcoholic fatty liver disease ³⁶ Oxidative phosphorylation ³⁶ Oxidative phosphorylation ¹ Respiratory electron transport ⁶⁵ The citric acid (TCA) cycle and respiratory electron transport ⁶⁵ Thermogenesis ³⁶	13.31	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RHEB
4	Cellular Senescence (REACTOME) ⁶⁵ Show member pathways Cellular responses to stress ⁶⁵ Cellular Senescence ⁶⁵ Oxidative Stress Induced Senescence ⁶⁵	13.13	TSC2 TSC1 RPTOR RHEB MTOR MLST8
5	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	13.07	VEGFD TSC2 TSC1 RPTOR RPS6KB1 RPS6
6	p70S6K Signaling ⁶³ Show member pathways mTOR Pathway ⁶³ Renin-Angiotensin Pathway ⁶³	13.03	VEGFD TSC2 TSC1 RPTOR RPS6KB1 RPS6
7	Regulation of TP53 Activity ⁶⁵ Show member pathways Regulation of TP53 Activity through Association with Co-factors ⁶⁵ Regulation of TP53 Activity through Methylation ⁶⁵ Regulation of TP53 Activity through Phosphorylation ⁶⁵ Transcriptional Regulation by TP53 ⁶⁵	13	TSC2 TSC1 RPTOR RICTOR RHEB MTOR
8	Regulation of lipid metabolism Insulin signaling-generic cascades ²³ Show member pathways acetyl-CoA biosynthesis from citrate ¹ Butyrate-induced histone acetylation ¹ Cell adhesion PLAU signaling ²³ Class IB PI3K non-lipid kinase events ¹ Development CNTF receptor signaling ²³ Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²³ ErbB2/ErbB3 signaling events ¹ Glucose Homeostasis ¹ Insulin signaling pathway ³⁶ IRS activation ⁶⁵ Signal attenuation ⁶⁵ Transcription Receptor-mediated HIF regulation ²³ Translation Regulation of EIF2 activity ²³ Translation Regulation of EIF4F activity ²³ Translation Insulin regulation of translation ²³	12.98	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RHEB
9	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	12.96	TSC2 TSC1 RPS6KB1 RHEB MTOR EIF4EBP1
10	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁶	12.86	TSC2 RPS6KB1 RHEB MTOR EIF4EBP1
11	Herpes simplex virus 1 infection ³⁶	12.8	TSC2 TSC1 RHEB MTOR EIF4EBP1
12	ErbB signaling pathway ³⁶ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ Renal cell carcinoma ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.67	TFE3 RPS6KB1 RPS6 MTOR FLCN EIF4EBP1
13	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.63	TSC2 TSC1 RPS6KB1 MTOR
14	AMP-activated Protein Kinase (AMPK) Signaling ¹ Show member pathways AMPK signaling pathway ³⁶ AMPK Signaling Pathway ⁶⁶	12.62	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RHEB
15	Development Endothelin-1/EDNRA signaling ²³ Show member pathways Cytoskeleton remodeling FAK signaling ²³ Development Endothelin-1/EDNRA transactivation of EGFR ²³ GnRH signaling pathway ³⁶ Inflammatory mediator regulation of TRP channels ³⁶	12.61	TSC2 RPS6KB1 RHEB MTOR
16	Angiopoietin Like Protein 8 Regulatory Pathway ¹ Show member pathways Insulin Signaling ¹ Liver X Receptor Pathway ¹	12.61	TSC2 TSC1 RPTOR RPS6KB1 RICTOR RHEB
17	Development IGF-1 receptor signaling ²³ Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²³ Signal transduction AKT signaling ²³	12.52	TSC2 TSC1 RPS6KB1 RPS6 RHEB MTOR
18	Phospholipase D signaling pathway ³⁶ Show member pathways Choline metabolism in cancer ³⁶	12.48	TSC2 TSC1 RPS6KB1 RHEB MTOR EIF4EBP1
19	Prolactin Signaling Pathway ¹ ³⁶ Show member pathways Development Prolactin receptor signaling ²³ Leptin signaling pathway ¹	12.47	RPS6KB1 RPS6 MTOR EIF4EBP1
20	Translation Non-genomic (rapid) action of Androgen Receptor ²³ Show member pathways Basal cell carcinoma ³⁶ Transcription Androgen Receptor nuclear signaling ²³	12.32	TSC2 RPS6KB1 MTOR EIF4EBP1
21	AMPK Enzyme Complex Pathway ⁶³ Show member pathways Chromatin Remodeling ⁶³ mitochondrial L-carnitine shuttle ¹	12.31	TSC2 TSC1 RPTOR RPS6KB1 MTOR EIF4EBP1
22	Longevity regulating pathway ³⁶ Show member pathways Longevity regulating pathway - multiple species ³⁶	12.27	TSC2 TSC1 RPTOR RPS6KB1 RHEB MTOR
23	Cellular senescence (KEGG) ³⁶	12.22	TSC2 TSC1 RHEB MTOR EIF4EBP1
24	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁴ Show member pathways Akt Signaling Pathway ⁶⁴	12.21	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RICTOR
25	EGF/EGFR Signaling Pathway ¹	12.2	RPS6KB1 RICTOR MTOR EIF4EBP1
26	Autophagy - animal ³⁶	12.2	TSC2 TSC1 RPTOR RPS6KB1 RHEB MTOR
27	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway ¹	12.18	TSC2 RPS6KB1 RPS6 MTOR EIF4EBP1
28	Integrated Breast Cancer Pathway ¹	12.17	TSC2 TSC1 RHEB MTOR
29	Translational Control ⁴	12.14	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RICTOR
30	Translation Translation regulation by Alpha-1 adrenergic receptors ²³ Show member pathways Development Activation of ERK by Alpha-1 adrenergic receptors ²³	12.1	TSC2 RPS6KB1 RHEB MTOR EIF4EBP1
31	mTOR signalling ⁶⁵ Show member pathways Energy dependent regulation of mTOR by LKB1-AMPK ⁶⁵ Inhibition of TSC complex formation by PKB ⁶⁵ mTORC1-mediated signalling ⁶⁵ PDE3B signalling ⁶⁵ PI3K Cascade ⁶⁵ PKB-mediated events ⁶⁵ Target Of Rapamycin (TOR) Signaling ¹	12.09	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RICTOR
32	Macroautophagy ⁶⁵ Show member pathways Autophagy - other ³⁶	12.05	TSC2 TSC1 RPTOR RHEB MTOR MLST8
33	Apelin signaling pathway ³⁶	12.04	RPS6KB1 RPS6 MTOR
34	Glioblastoma Multiforme ⁶³	12.02	TSC2 TSC1 RPS6KB1 MTOR
35	HIF-1 signaling pathway ³⁶	12.01	RPS6KB1 RPS6 MTOR EIF4EBP1
36	Thyroid hormone signaling pathway ³⁶	11.98	TSC2 RHEB MTOR
37	ErbB1 downstream signaling ¹	11.98	RPS6 RICTOR MTOR MLST8
38	TP53 Regulates Metabolic Genes ⁶⁵	11.97	TSC2 TSC1 RPTOR RHEB MTOR MLST8
39	PI3K / Akt Signaling ⁴	11.93	TSC2 TSC1 TBC1D7 RHEB
40	Interferon Pathway ⁶³	11.92	RPS6KB1 RPS6 MTOR EIF4EBP1
41	mTOR signaling pathway (KEGG) ³⁶ Show member pathways mTOR Signaling Pathway ⁶⁴	11.9	TSC2 TSC1 TBC1D7 RPTOR RPS6KB1 RPS6
42	Constitutive Signaling by AKT1 E17K in Cancer ⁶⁵ Show member pathways AKT phosphorylates targets in the cytosol ⁶⁵ AKT phosphorylates targets in the nucleus ⁶⁵ AKT-mediated inactivation of FOXO1A ⁶⁵ Class I PI3K signaling events mediated by Akt ¹	11.89	TSC2 RICTOR MTOR MLST8
43	CXCR4-mediated signaling events ¹	11.77	RICTOR MTOR MLST8
44	Regulation of TP53 Expression and Degradation ⁶⁵ Show member pathways Regulation of TP53 Degradation ⁶⁵ Regulation of TP53 Expression ⁶⁵	11.75	RICTOR MTOR MLST8
45	Interferon type I signaling pathways ¹	11.73	RPTOR RPS6KB1 RPS6 MTOR MLST8 EIF4EBP1
46	Human Thyroid Stimulating Hormone (TSH) signaling pathway ¹	11.71	RPS6KB1 RPS6 MTOR
47	IL2 signaling events mediated by PI3K ¹ Show member pathways IL2 signaling events mediated by STAT5 ¹	11.7	RPS6KB1 RPS6 MTOR
48	mTOR signaling pathway (Pathway Interaction Database) ¹	11.69	TSC2 TSC1 RPTOR RPS6KB1 RICTOR RHEB
49	LKB1 signaling events ¹	11.61	TSC2 TSC1 RPTOR MTOR MLST8
50	Wnt Signaling Pathway Netpath ¹	11.6	TSC2 TSC1 MTOR

Sources

GO Terms for Kidney Angiomyolipoma

Cellular components related to Kidney Angiomyolipoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:0005737	10.22	TSC2 TSC1 TFE3 RPTOR RPS6KB1 RPS6
2	lysosome	GO:0005764	9.77	TSC2 RPTOR MTOR FNIP1 FLCN
3	lysosomal membrane	GO:0005765	9.72	RPTOR RHEB MTOR FNIP1 FLCN
4	cytosol	GO:0005829	9.5	TSC2 TSC1 TFE3 TBC1D7 RPTOR RPS6KB1
5	postsynaptic cytosol	GO:0099524	9.43	MTOR EIF4EBP1
6	TORC2 complex	GO:0031932	9.33	RICTOR MTOR MLST8
7	TSC1-TSC2 complex	GO:0033596	9.26	TSC2 TSC1
8	TORC1 complex	GO:0031931	9.13	RPTOR MTOR MLST8

Biological processes related to Kidney Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 36)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of protein phosphorylation	GO:0001934	9.87	VEGFD MTOR FNIP1 FLCN
2	G1/S transition of mitotic cell cycle	GO:0000082	9.81	RPS6KB1 RPS6 EIF4EBP1
3	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.81	RICTOR MTOR MLST8
4	regulation of GTPase activity	GO:0043087	9.8	RICTOR MTOR MLST8
5	response to insulin	GO:0032868	9.77	TSC1 RPS6KB1 MTOR
6	response to nutrient levels	GO:0031667	9.77	TSC1 RPS6KB1 MTOR
7	regulation of cellular response to heat	GO:1900034	9.76	RPTOR MTOR MLST8
8	cell cycle arrest	GO:0007050	9.76	RPTOR RHEB MTOR MLST8
9	regulation of actin cytoskeleton organization	GO:0032956	9.75	RICTOR MTOR MLST8
10	positive regulation of protein serine/threonine kinase activity	GO:0071902	9.73	RPTOR RICTOR MLST8
11	cellular response to starvation	GO:0009267	9.73	RPTOR MTOR FNIP1 FLCN
12	positive regulation of actin filament polymerization	GO:0030838	9.72	RICTOR MTOR MLST8
13	regulation of macroautophagy	GO:0016241	9.71	RPTOR RHEB MTOR MLST8
14	negative regulation of cold-induced thermogenesis	GO:0120163	9.7	TFE3 RHEB FLCN
15	regulation of cell size	GO:0008361	9.67	RPTOR MTOR
16	positive regulation of oligodendrocyte differentiation	GO:0048714	9.67	RHEB MTOR
17	negative regulation of insulin receptor signaling pathway	GO:0046627	9.67	TSC2 TSC1 RPS6KB1
18	positive regulation of endothelial cell proliferation	GO:0001938	9.67	VEGFD RPTOR RICTOR MTOR
19	regulation of TOR signaling	GO:0032006	9.66	RHEB FLCN
20	regulation of phosphorylation	GO:0042325	9.66	RPTOR RICTOR
21	regulation of protein kinase B signaling	GO:0051896	9.65	RICTOR MTOR
22	regulation of osteoclast differentiation	GO:0045670	9.65	TFE3 MTOR
23	negative regulation of macroautophagy	GO:0016242	9.65	TSC1 MTOR
24	activation of protein kinase B activity	GO:0032148	9.65	RICTOR MTOR MLST8
25	cellular response to nutrient levels	GO:0031669	9.64	RPTOR MTOR
26	positive regulation of transcription by RNA polymerase III	GO:0045945	9.62	RPTOR MTOR
27	anoikis	GO:0043276	9.62	TSC2 MTOR
28	regulation of protein phosphorylation	GO:0001932	9.62	RICTOR MTOR FNIP1 FLCN
29	cellular response to leucine	GO:0071233	9.61	RPTOR MTOR
30	negative regulation of cell size	GO:0045792	9.61	TSC1 MTOR
31	negative regulation of TOR signaling	GO:0032007	9.55	TSC2 TSC1 TBC1D7 FNIP1 FLCN
32	negative regulation of mitochondrion organization	GO:0010823	9.54	FNIP1 FLCN
33	regulation of pro-B cell differentiation	GO:2000973	9.51	FNIP1 FLCN
34	TORC1 signaling	GO:0038202	9.43	RPTOR MTOR MLST8
35	positive regulation of TOR signaling	GO:0032008	9.43	RPTOR RICTOR RHEB MLST8 FNIP1 FLCN
36	TOR signaling	GO:0031929	9.28	RPTOR RPS6KB1 RPS6 RICTOR MTOR MLST8

Molecular functions related to Kidney Angiomyolipoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	10.33	VEGFD TSC2 TSC1 TFE3 TBC1D7 RPTOR
2	protein kinase binding	GO:0019901	9.77	RPTOR RPS6 RICTOR RHEB MTOR
3	protein-containing complex binding	GO:0044877	9.73	TSC1 RPTOR MTOR FLCN
4	RNA polymerase III type 3 promoter sequence-specific DNA binding	GO:0001006	9.32	RPTOR MTOR
5	ATPase inhibitor activity	GO:0042030	9.26	TSC1 FNIP1
6	TFIIIC-class transcription factor complex binding	GO:0001156	9.16	RPTOR MTOR
7	RNA polymerase III type 2 promoter sequence-specific DNA binding	GO:0001003	8.96	RPTOR MTOR
8	RNA polymerase III type 1 promoter sequence-specific DNA binding	GO:0001002	8.62	RPTOR MTOR

Sources

Sources for Kidney Angiomyolipoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

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⁶¹ PubMed

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⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia