MCID: KDN016
MIFTS: 29

Kidney Benign Neoplasm

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Kidney Benign Neoplasm

MalaCards integrated aliases for Kidney Benign Neoplasm:

Name: Kidney Benign Neoplasm 12 15
Renal and Ureteral Tumor 12
Benign Kidney Neoplasm 17

Classifications:



External Ids:

Disease Ontology 12 DOID:3116
NCIt 49 C7514
ICD10 32 D30.0
UMLS 71 C1334323

Summaries for Kidney Benign Neoplasm

MalaCards based summary : Kidney Benign Neoplasm, also known as renal and ureteral tumor, is related to nephroma and oncocytoma. An important gene associated with Kidney Benign Neoplasm is TSC2 (TSC Complex Subunit 2), and among its related pathways/superpathways are Angiopoietin Like Protein 8 Regulatory Pathway and AMP-activated Protein Kinase (AMPK) Signaling. The drug pyruvate has been mentioned in the context of this disorder. Affiliated tissues include kidney, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Kidney Benign Neoplasm

Diseases related to Kidney Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 nephroma 31.5 WT1 TFE3 MME MEST ETV6 DICER1
2 oncocytoma 29.7 PAX2 MME KRT7 FLCN CDH16 AMACR
3 angiomyolipoma 28.9 VEGFD TSC2 TSC1 TFE3 PAX8 MTOR
4 renal cell carcinoma, nonpapillary 27.8 WT1 VEGFD TSC2 TSC1 TFE3 PRCC
5 childhood multilocular cystic kidney neoplasm 11.2
6 fallopian tube leiomyoma 10.6 TSC2 MME
7 fallopian tube benign neoplasm 10.6 TSC2 MME
8 vaginal adenosarcoma 10.5 MTOR MME
9 vaginal carcinosarcoma 10.5 MTOR MME
10 lissencephaly with cerebellar hypoplasia 10.5 TSC2 TSC1
11 subareolar duct papillomatosis 10.5 MME KRT7
12 nipple benign neoplasm 10.5 MME KRT7
13 microinvasive cervical squamous cell carcinoma 10.5 WT1 KRT7
14 pancreatic serous cystadenocarcinoma 10.5 MME KRT7
15 microcystic stromal tumor 10.5 WT1 DICER1
16 rete testis neoplasm 10.5 PAX8 KRT7
17 renal cell carcinoma, xp11-associated 10.5 TFE3 PRCC
18 rete testis adenocarcinoma 10.5 PAX8 KRT7
19 childhood kidney cell carcinoma 10.5 TFE3 PRCC
20 renal pelvis adenocarcinoma 10.5 PAX8 KRT7
21 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.5 TSC2 TSC1 FLCN
22 focal cortical dysplasia, type ii 10.5 TSC2 TSC1 MTOR
23 corneal dystrophy, fleck 10.5 TSC2 TSC1 MTOR
24 anal canal paget's disease 10.5 MLANA KRT7
25 glandular cystitis 10.5 KRT7 AMACR
26 anal paget's disease 10.5 MLANA KRT7
27 krukenberg carcinoma 10.5 PAX8 KRT7
28 prostatic acinar adenocarcinoma 10.5 PAX8 AMACR
29 benign ependymoma 10.5 TSC2 TSC1 MTOR
30 female urethral cancer 10.5 MME KRT7 AMACR
31 leiomyoma cutis 10.5 PRCC FLCN
32 cervix endometriosis 10.5 PAX2 MME
33 dermis tumor 10.5 PRCC FLCN
34 vulval paget's disease 10.5 MLANA KRT7
35 malignant biphasic mesothelioma 10.5 WT1 KRT7
36 ovarian brenner tumor 10.5 WT1 KRT7
37 seminal vesicle adenocarcinoma 10.5 PAX8 KRT7 AMACR
38 pericardium cancer 10.5 WT1 KRT7
39 melanoacanthoma 10.4 MTOR MLANA
40 rete testis adenoma 10.4 PAX8 PAX2
41 adult cystic nephroma 10.4 MME MEST
42 urethral diverticulum 10.4 PAX8 KRT7 AMACR
43 eosinophilic variant of chromophobe renal cell carcinoma 10.4 TFE3 CDH16
44 familial renal papillary carcinoma 10.4 TFE3 PRCC FLCN
45 pancreatic mucinous cystadenoma 10.4 MME KRT7
46 reproductive organ benign neoplasm 10.4 TSC2 MME KRT7
47 colon leiomyosarcoma 10.4 WT1 PAX8
48 sensory organ benign neoplasm 10.4 MLANA KRT7
49 ovarian mucinous neoplasm 10.4 PAX8 KRT7
50 breast osteosarcoma 10.4 WT1 MME KRT7

Graphical network of the top 20 diseases related to Kidney Benign Neoplasm:



Diseases related to Kidney Benign Neoplasm

Symptoms & Phenotypes for Kidney Benign Neoplasm

GenomeRNAi Phenotypes related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.68 MTOR
2 Decreased viability GR00055-A-2 9.68 MTOR
3 Decreased viability GR00221-A-1 9.68 MTOR RHEB
4 Decreased viability GR00221-A-2 9.68 TSC1
5 Decreased viability GR00221-A-3 9.68 TSC1
6 Decreased viability GR00221-A-4 9.68 MTOR
7 Decreased viability GR00240-S-1 9.68 PAX8
8 Decreased viability GR00249-S 9.68 AMACR B3GAT1 CDH16
9 Decreased viability GR00301-A 9.68 TSC1
10 Decreased viability GR00342-S-1 9.68 MTOR
11 Decreased viability GR00342-S-2 9.68 MTOR
12 Decreased viability GR00381-A-1 9.68 CDH16 MEST WT1
13 Decreased viability GR00386-A-1 9.68 B3GAT1 CDH16 RHEB TFE3
14 Decreased viability GR00402-S-2 9.68 B3GAT1 PAX8

MGI Mouse Phenotypes related to Kidney Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.25 DICER1 ETV6 FLCN KRT7 MEST MME
2 cardiovascular system MP:0005385 10.23 DICER1 ETV6 FLCN MEST MTOR PAX2
3 growth/size/body region MP:0005378 10.18 AMACR DICER1 ETV6 FLCN MEST MTOR
4 embryo MP:0005380 10.14 DICER1 ETV6 FLCN MEST MTOR PAX2
5 homeostasis/metabolism MP:0005376 10.13 AMACR DICER1 ETV6 FLCN KRT7 MME
6 mortality/aging MP:0010768 10.13 AMACR B3GAT1 DICER1 ETV6 FLCN MEST
7 neoplasm MP:0002006 9.7 DICER1 ETV6 FLCN TSC1 TSC2 VEGFD
8 normal MP:0002873 9.61 DICER1 ETV6 MTOR PAX8 RHEB TFE3
9 renal/urinary system MP:0005367 9.28 DICER1 FLCN KRT7 MTOR PAX2 PAX8

Drugs & Therapeutics for Kidney Benign Neoplasm

Drugs for Kidney Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 pyruvate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hyperpolarized 13C Pyruvate Metabolic MRI to Predict Renal Tumor Aggressiveness Recruiting NCT04258462 Phase 2 Hyperpolarized Carbon C 13 Pyruvate

Search NIH Clinical Center for Kidney Benign Neoplasm

Genetic Tests for Kidney Benign Neoplasm

Anatomical Context for Kidney Benign Neoplasm

MalaCards organs/tissues related to Kidney Benign Neoplasm:

40
Kidney

Publications for Kidney Benign Neoplasm

Variations for Kidney Benign Neoplasm

Expression for Kidney Benign Neoplasm

Search GEO for disease gene expression data for Kidney Benign Neoplasm.

Pathways for Kidney Benign Neoplasm

Pathways related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.39 TSC2 TSC1 RHEB MTOR
2
Show member pathways
12.36 TSC2 TSC1 RHEB MTOR
3
Show member pathways
12.32 TSC2 TSC1 RHEB MTOR FLCN
4
Show member pathways
12.28 TSC2 TSC1 RHEB MTOR
5
Show member pathways
12.27 TSC2 TSC1 RHEB MTOR
6
Show member pathways
12.25 TSC2 TSC1 RHEB MTOR
7 12.03 TSC2 TSC1 RHEB MTOR
8 12.01 TSC2 TSC1 RHEB MTOR
9
Show member pathways
11.99 TSC2 TSC1 RHEB MTOR
10 11.94 TSC2 TSC1 MTOR FLCN DICER1
11 11.91 TSC2 TSC1 RHEB MTOR
12 11.84 WT1 TFE3 PRCC PAX8 ETV6
13 11.73 TSC2 TSC1 RHEB
14
Show member pathways
11.66 TSC2 TSC1 RHEB MTOR
15 11.6 WT1 PAX2 MME
16 11.55 TSC2 TSC1 RHEB MTOR
17 11.45 TSC2 TSC1 MTOR
18 11.29 TSC2 TSC1 MTOR
19 11.09 TSC2 RHEB MTOR
20 11.03 TSC2 TSC1 RHEB MTOR
21 11.01 TSC2 RHEB MTOR
22 10.81 PAX8 PAX2
23 10.44 TSC2 TSC1 RHEB MTOR

GO Terms for Kidney Benign Neoplasm

Cellular components related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 TSC1-TSC2 complex GO:0033596 8.62 TSC2 TSC1

Biological processes related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 neural tube closure GO:0001843 9.79 TSC2 TSC1 PAX2
2 kidney development GO:0001822 9.73 WT1 TSC1 PAX8 MME
3 negative regulation of cold-induced thermogenesis GO:0120163 9.71 TFE3 RHEB FLCN
4 branching involved in ureteric bud morphogenesis GO:0001658 9.7 WT1 PAX8 PAX2
5 urogenital system development GO:0001655 9.64 PAX8 PAX2
6 regulation of osteoclast differentiation GO:0045670 9.63 TFE3 MTOR
7 negative regulation of macroautophagy GO:0016242 9.63 TSC1 MTOR
8 mesonephros development GO:0001823 9.62 PAX8 PAX2
9 anoikis GO:0043276 9.61 TSC2 MTOR
10 negative regulation of cell size GO:0045792 9.61 TSC1 MTOR
11 mesenchymal to epithelial transition GO:0060231 9.6 WT1 PAX2
12 metanephric mesenchyme development GO:0072075 9.59 WT1 PAX2
13 cellular response to gonadotropin stimulus GO:0071371 9.58 WT1 PAX8
14 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.58 PAX8 PAX2
15 negative regulation of TOR signaling GO:0032007 9.58 TSC2 TSC1 FLCN
16 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.57 PAX8 PAX2
17 pronephros development GO:0048793 9.56 PAX8 PAX2
18 metanephric S-shaped body morphogenesis GO:0072284 9.55 WT1 PAX8
19 metanephric nephron tubule formation GO:0072289 9.51 PAX8 PAX2
20 metanephric distal convoluted tubule development GO:0072221 9.49 PAX8 PAX2
21 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.48 PAX8 PAX2
22 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.46 PAX8 PAX2
23 positive regulation of metanephric DCT cell differentiation GO:2000594 9.37 PAX8 PAX2
24 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.32 PAX8 PAX2
25 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.26 PAX8 PAX2
26 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.16 PAX8 PAX2
27 pronephric field specification GO:0039003 8.96 PAX8 PAX2
28 metanephric epithelium development GO:0072207 8.8 WT1 PAX8 PAX2

Molecular functions related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 8.92 WT1 TFE3 PAX8 PAX2

Sources for Kidney Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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