MCID: KDN016
MIFTS: 31

Kidney Benign Neoplasm

Categories: Cancer diseases, Nephrological diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Kidney Benign Neoplasm

MalaCards integrated aliases for Kidney Benign Neoplasm:

Name: Kidney Benign Neoplasm 12 15
Renal and Ureteral Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3116
NCIt 50 C7514
ICD10 33 D30.0
UMLS 73 C1334323

Summaries for Kidney Benign Neoplasm

MalaCards based summary : Kidney Benign Neoplasm, also known as renal and ureteral tumor, is related to epithelial predominant wilms' tumor and ovarian mucinous adenocarcinoma. An important gene associated with Kidney Benign Neoplasm is TSC2 (TSC Complex Subunit 2), and among its related pathways/superpathways are Endometrial cancer and mTOR signaling pathway (KEGG). Affiliated tissues include kidney, and related phenotypes are cellular and cardiovascular system

Related Diseases for Kidney Benign Neoplasm

Diseases in the Kidney Cancer family:

Kidney Benign Neoplasm Kidney Carcinoma in Situ
Renal Carcinoma, Familial

Diseases related to Kidney Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 epithelial predominant wilms' tumor 10.7 AMACR KRT7
2 ovarian mucinous adenocarcinoma 10.7 AMACR KRT7
3 balloon cell malignant melanoma 10.7 KRT7 MME
4 bladder diverticulum 10.7 AMACR PAX2
5 sertoli-leydig cell tumor 10.7 DICER1 KRT7
6 cervical adenoma malignum 10.7 KRT7 MME
7 cervical mucinous adenocarcinoma 10.7 KRT7 MME
8 metanephric adenoma 10.7 AMACR KRT7
9 atypical choroid plexus papilloma 10.6 DICER1 KRT7
10 cervix endometriosis 10.6 MME PAX2
11 bladder lymphoma 10.6 KRT7 MME
12 adenomyoma 10.6 KRT7 MME
13 endosalpingiosis 10.6 KRT7 PAX8
14 renal pelvis adenocarcinoma 10.6 KRT7 PAX8
15 breast adenomyoepithelioma 10.6 KRT7 MME
16 rete testis adenoma 10.6 PAX2 PAX8
17 childhood endodermal sinus tumor 10.6 PAX2 PAX8
18 endocervical carcinoma 10.6 KRT7 PAX8
19 breast myoepithelial neoplasm 10.6 KRT7 MME
20 childhood kidney cell carcinoma 10.5 PAX2 TSC2
21 reproductive organ benign neoplasm 10.5 DICER1 TSC2
22 jejunal cancer 10.5 KIT KRT7
23 infiltrative basal cell carcinoma 10.5 KRT7 MME
24 hereditary renal cell carcinoma 10.5 FLCN TSC2
25 renal pelvis carcinoma 10.5 KRT7 PAX8
26 clear cell hidradenoma 10.5 MME PAX8
27 urethra adenocarcinoma 10.5 AMACR PAX8
28 cribriform carcinoma 10.5 KIT KRT7
29 urethra clear cell adenocarcinoma 10.5 AMACR PAX8
30 malignant mixed mullerian tumor 10.5 KIT KRT7
31 spermatocele 10.5 MME PAX2
32 horseshoe kidney 10.5 KRT7 TSC2
33 adenoid basal cell carcinoma 10.5 KIT KRT7
34 intratubular embryonal carcinoma 10.5 KIT KRT7
35 cystadenofibroma 10.5 KRT7 MME
36 pleomorphic carcinoma 10.4 KIT KRT7
37 renal adenoma 10.4 AMACR KRT7 PAX2
38 benign breast phyllodes tumor 10.4 KIT MME
39 large intestine adenocarcinoma 10.4 KRT7 MTOR
40 large cell acanthoma 10.4 KRT7 MTOR
41 clear cell adenocarcinoma 10.4 AMACR KRT7 PAX2
42 clear cell papillary renal cell carcinoma 10.4 AMACR KRT7 MME
43 rete testis adenocarcinoma 10.4 KIT MME
44 mucinous tubular and spindle renal cell carcinoma 10.4 AMACR KRT7 MME
45 dermoid cyst 10.3 KIT KRT7
46 papillary hidradenoma 10.3 KIT MME
47 mixed type thymoma 10.3 KIT PAX8
48 adenosarcoma 10.3 KIT MME
49 spindle cell carcinoma 10.3 AMACR CDH16 KRT7
50 sarcomatoid renal cell carcinoma 10.3 KIT PAX8

Graphical network of the top 20 diseases related to Kidney Benign Neoplasm:



Diseases related to Kidney Benign Neoplasm

Symptoms & Phenotypes for Kidney Benign Neoplasm

MGI Mouse Phenotypes related to Kidney Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.09 MTOR PAX2 FLCN PAX8 KIT KRT7
2 cardiovascular system MP:0005385 10.06 MTOR PAX2 FLCN PAX8 KIT DICER1
3 homeostasis/metabolism MP:0005376 10.02 FLCN PAX8 KIT TSC1 AMACR KRT7
4 embryo MP:0005380 10.01 PAX2 FLCN PAX8 KIT TSC1 DICER1
5 endocrine/exocrine gland MP:0005379 9.91 DICER1 MTOR PAX2 PAX8 KIT TSC2
6 mortality/aging MP:0010768 9.81 DICER1 MTOR PAX2 FLCN PAX8 KIT
7 liver/biliary system MP:0005370 9.73 DICER1 KIT AMACR MME TSC2 TSC1
8 neoplasm MP:0002006 9.35 DICER1 FLCN KIT TSC2 TSC1
9 renal/urinary system MP:0005367 9.28 PAX2 FLCN PAX8 KIT TSC1 KRT7

Drugs & Therapeutics for Kidney Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Kidney Benign Neoplasm

Genetic Tests for Kidney Benign Neoplasm

Anatomical Context for Kidney Benign Neoplasm

MalaCards organs/tissues related to Kidney Benign Neoplasm:

41
Kidney

Publications for Kidney Benign Neoplasm

Variations for Kidney Benign Neoplasm

Expression for Kidney Benign Neoplasm

Search GEO for disease gene expression data for Kidney Benign Neoplasm.

Pathways for Kidney Benign Neoplasm

Pathways related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 KIT MTOR PAX8 TSC2
2
Show member pathways
12.2 FLCN MTOR TSC1 TSC2
3
Show member pathways
12.1 MTOR TSC1 TSC2
4
Show member pathways
12.06 KIT MTOR TSC1 TSC2
5
Show member pathways
12 MTOR TSC1 TSC2
6 11.96 MTOR TSC1 TSC2
7 11.93 MTOR TSC1 TSC2
8
Show member pathways
11.91 MTOR TSC1 TSC2
9
Show member pathways
11.9 MTOR TSC1 TSC2
10 11.81 MTOR TSC1 TSC2
11
Show member pathways
11.79 MTOR TSC1 TSC2
12
Show member pathways
11.76 MTOR TSC1 TSC2
13 11.7 MTOR TSC1 TSC2
14 11.56 MTOR TSC1 TSC2
15 11.3 DICER1 FLCN MTOR TSC1 TSC2
16 11.28 MTOR TSC1 TSC2
17 11.16 MTOR TSC1 TSC2
18 11.08 MTOR TSC2
19 11.02 MTOR TSC2
20 10.96 MTOR TSC1 TSC2
21 10.79 MTOR TSC1
22 10.7 PAX2 PAX8
23 10.66 MTOR TSC1 TSC2

GO Terms for Kidney Benign Neoplasm

Cellular components related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosome GO:0005764 9.26 FLCN MTOR PAX2 TSC2
2 TSC1-TSC2 complex GO:0033596 8.62 TSC1 TSC2

Biological processes related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 cell cycle arrest GO:0007050 9.8 MTOR TSC1 TSC2
2 kidney development GO:0001822 9.75 MME PAX8 TSC1
3 neural tube closure GO:0001843 9.72 PAX2 TSC1 TSC2
4 negative regulation of insulin receptor signaling pathway GO:0046627 9.64 TSC1 TSC2
5 positive regulation of macroautophagy GO:0016239 9.63 TSC1 TSC2
6 stem cell differentiation GO:0048863 9.63 KIT PAX2
7 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.62 PAX2 PAX8
8 TOR signaling GO:0031929 9.61 FLCN MTOR
9 negative regulation of programmed cell death GO:0043069 9.61 KIT PAX2
10 urogenital system development GO:0001655 9.6 PAX2 PAX8
11 negative regulation of macroautophagy GO:0016242 9.59 MTOR TSC1
12 mesonephros development GO:0001823 9.58 PAX2 PAX8
13 anoikis GO:0043276 9.57 MTOR TSC2
14 negative regulation of cell size GO:0045792 9.56 MTOR TSC1
15 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.54 PAX2 PAX8
16 negative regulation of TOR signaling GO:0032007 9.54 FLCN TSC1 TSC2
17 pronephros development GO:0048793 9.52 PAX2 PAX8
18 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.51 PAX2 PAX8
19 metanephric epithelium development GO:0072207 9.49 PAX2 PAX8
20 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.48 PAX2 PAX8
21 metanephric nephron tubule formation GO:0072289 9.46 PAX2 PAX8
22 metanephric distal convoluted tubule development GO:0072221 9.43 PAX2 PAX8
23 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.4 PAX2 PAX8
24 pronephric field specification GO:0039003 9.32 PAX2 PAX8
25 positive regulation of metanephric DCT cell differentiation GO:2000594 9.26 PAX2 PAX8
26 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.16 PAX2 PAX8
27 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 8.96 PAX2 PAX8
28 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 8.62 PAX2 PAX8

Sources for Kidney Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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