MCID: KDN016
MIFTS: 32

Kidney Benign Neoplasm

Categories: Cancer diseases, Genetic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Kidney Benign Neoplasm

MalaCards integrated aliases for Kidney Benign Neoplasm:

Name: Kidney Benign Neoplasm 12 15
Renal and Ureteral Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3116
NCIt 50 C7514
ICD10 33 D30.0
UMLS 73 C1334323

Summaries for Kidney Benign Neoplasm

MalaCards based summary : Kidney Benign Neoplasm, also known as renal and ureteral tumor, is related to papillary adenoma and ovarian mucinous adenocarcinoma. An important gene associated with Kidney Benign Neoplasm is KRT7 (Keratin 7), and among its related pathways/superpathways are Translational Control and Primary Focal Segmental Glomerulosclerosis FSGS. Affiliated tissues include kidney, liver and bone, and related phenotypes are cellular and cardiovascular system

Related Diseases for Kidney Benign Neoplasm

Diseases in the Kidney Cancer family:

Kidney Benign Neoplasm Kidney Carcinoma in Situ
Renal Carcinoma, Familial

Diseases related to Kidney Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 papillary adenoma 10.3 AMACR KRT7
2 ovarian mucinous adenocarcinoma 10.3 AMACR KRT7
3 balloon cell malignant melanoma 10.2 KRT7 MME
4 cervical adenoma malignum 10.2 KRT7 MME
5 cervical mucinous adenocarcinoma 10.2 KRT7 MME
6 malignant leydig cell tumor 10.2 KRT7 MME
7 bladder lymphoma 10.2 KRT7 MME
8 adenomyoma 10.2 KRT7 MME
9 bladder diverticulum 10.2 AMACR PAX2
10 breast adenomyoepithelioma 10.2 KRT7 MME
11 breast myoepithelial neoplasm 10.2 KRT7 MME
12 atypical choroid plexus papilloma 10.2 DICER1 KRT7
13 eccrine sweat gland neoplasm 10.2 KRT7 MME
14 perivascular epithelioid cell tumor 10.2 MME TSC2
15 infiltrative basal cell carcinoma 10.2 KRT7 MME
16 cystadenofibroma 10.2 KRT7 MME
17 cervix endometriosis 10.2 MME PAX2
18 pancreatic mucinous cystadenoma 10.2 KRT7 MME
19 horseshoe kidney 10.2 KRT7 TSC2
20 childhood kidney cell carcinoma 10.2 PAX2 TSC2
21 large intestine adenocarcinoma 10.2 KRT7 MTOR
22 renal pelvis adenocarcinoma 10.2 KRT7 PAX8
23 sensory organ benign neoplasm 10.2 KRT7 PAX8
24 spermatocele 10.2 MME PAX2
25 large cell acanthoma 10.2 KRT7 MTOR
26 endocervical carcinoma 10.2 KRT7 PAX8
27 hepatic angiomyolipoma 10.2 MTOR TSC2
28 mixed cell type cancer 10.2 KRT7 MME
29 renal pelvis carcinoma 10.2 KRT7 PAX8
30 clear cell adenofibroma 10.2 KRT7 MTOR
31 subependymal glioma 10.1 MTOR TSC2
32 clear cell papillary renal cell carcinoma 10.1 AMACR KRT7 MME
33 mucinous tubular and spindle renal cell carcinoma 10.1 AMACR KRT7 MME
34 benign ependymoma 10.1 MTOR TSC2
35 clear cell hidradenoma 10.1 MME PAX8
36 rete testis adenoma 10.1 PAX2 PAX8
37 childhood endodermal sinus tumor 10.1 PAX2 PAX8
38 benign mesothelioma 10.1 KRT7 WT1
39 benign glioma 10.1 MTOR TSC2
40 cervical adenosquamous carcinoma 10.1 KRT7 PAX8
41 female reproductive endometrioid cancer 10.1 KRT7 WT1
42 ileum cancer 10.1 KRT7 MME
43 malignant biphasic mesothelioma 10.1 KRT7 WT1
44 kidney sarcoma 10.1 DICER1 WT1
45 testicular granulosa cell tumor 10.1 DICER1 WT1
46 adenomatoid tumor 10.1 KRT7 WT1
47 juvenile type testicular granulosa cell tumor 10.1 DICER1 WT1
48 subependymal giant cell astrocytoma 10.1 MTOR TSC2
49 male reproductive organ benign neoplasm 10.1 DICER1 WT1
50 spindle cell carcinoma 10.1 AMACR CDH16 KRT7

Graphical network of the top 20 diseases related to Kidney Benign Neoplasm:



Diseases related to Kidney Benign Neoplasm

Symptoms & Phenotypes for Kidney Benign Neoplasm

MGI Mouse Phenotypes related to Kidney Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.92 DICER1 FLCN KRT7 MTOR PAX2 PAX8
2 cardiovascular system MP:0005385 9.91 DICER1 FLCN MTOR PAX2 PAX8 TSC2
3 homeostasis/metabolism MP:0005376 9.81 AMACR DICER1 FLCN KRT7 MME MTOR
4 embryo MP:0005380 9.8 DICER1 FLCN MTOR PAX2 PAX8 TSC2
5 mortality/aging MP:0010768 9.61 AMACR B3GAT1 DICER1 FLCN MTOR PAX2
6 renal/urinary system MP:0005367 9.23 DICER1 FLCN KRT7 MTOR PAX2 PAX8

Drugs & Therapeutics for Kidney Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Kidney Benign Neoplasm

Genetic Tests for Kidney Benign Neoplasm

Anatomical Context for Kidney Benign Neoplasm

MalaCards organs/tissues related to Kidney Benign Neoplasm:

41
Kidney, Liver, Bone, Heart, Ovary, Prostate, Testis

Publications for Kidney Benign Neoplasm

Variations for Kidney Benign Neoplasm

Expression for Kidney Benign Neoplasm

Search GEO for disease gene expression data for Kidney Benign Neoplasm.

Pathways for Kidney Benign Neoplasm

Pathways related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.21 DICER1 FLCN MTOR TSC2
2 11 MME PAX2 WT1
3 10.9 MTOR TSC2
4 10.8 MTOR TSC2
5 10.69 MTOR TSC2
6 10.36 PAX2 PAX8

GO Terms for Kidney Benign Neoplasm

Cellular components related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosome GO:0005764 8.92 FLCN MTOR PAX2 TSC2

Biological processes related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.77 MME PAX8 WT1
2 germ cell development GO:0007281 9.63 MTOR WT1
3 protein kinase B signaling GO:0043491 9.63 PAX2 TSC2
4 negative regulation of TOR signaling GO:0032007 9.62 FLCN TSC2
5 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.62 PAX2 PAX8
6 TOR signaling GO:0031929 9.61 FLCN MTOR
7 urogenital system development GO:0001655 9.61 PAX2 PAX8
8 branching involved in ureteric bud morphogenesis GO:0001658 9.61 PAX2 PAX8 WT1
9 mesonephros development GO:0001823 9.59 PAX2 PAX8
10 anoikis GO:0043276 9.58 MTOR TSC2
11 mesenchymal to epithelial transition GO:0060231 9.58 PAX2 WT1
12 cellular response to gonadotropin stimulus GO:0071371 9.57 PAX8 WT1
13 metanephric mesenchyme development GO:0072075 9.56 PAX2 WT1
14 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.55 PAX2 PAX8
15 pronephros development GO:0048793 9.54 PAX2 PAX8
16 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.52 PAX2 PAX8
17 metanephric S-shaped body morphogenesis GO:0072284 9.51 PAX8 WT1
18 metanephric distal convoluted tubule development GO:0072221 9.49 PAX2 PAX8
19 metanephric nephron tubule formation GO:0072289 9.48 PAX2 PAX8
20 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.46 PAX2 PAX8
21 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.4 PAX2 PAX8
22 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.37 PAX2 PAX8
23 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.32 PAX2 PAX8
24 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.26 PAX2 PAX8
25 positive regulation of metanephric DCT cell differentiation GO:2000594 9.16 PAX2 PAX8
26 pronephric field specification GO:0039003 8.96 PAX2 PAX8
27 metanephric epithelium development GO:0072207 8.8 PAX2 PAX8 WT1

Sources for Kidney Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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