MCID: KDN016
MIFTS: 30

Kidney Benign Neoplasm

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Kidney Benign Neoplasm

MalaCards integrated aliases for Kidney Benign Neoplasm:

Name: Kidney Benign Neoplasm 12 15
Renal and Ureteral Tumor 12
Benign Kidney Neoplasm 17

Classifications:



External Ids:

Disease Ontology 12 DOID:3116
NCIt 49 C7514
ICD10 32 D30.0
UMLS 71 C1334323

Summaries for Kidney Benign Neoplasm

MalaCards based summary : Kidney Benign Neoplasm, also known as renal and ureteral tumor, is related to oncocytoma and angiomyolipoma. An important gene associated with Kidney Benign Neoplasm is TSC2 (TSC Complex Subunit 2), and among its related pathways/superpathways are p70S6K Signaling and PI3K-Akt signaling pathway. Affiliated tissues include kidney, breast and testis, and related phenotypes are cellular and cardiovascular system

Related Diseases for Kidney Benign Neoplasm

Diseases related to Kidney Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 oncocytoma 28.7 S100A1 PAX2 MME KRT7 KIT FLCN
2 angiomyolipoma 27.7 VEGFD TSC2 TSC1 TFE3 S100A1 PAX8
3 renal cell carcinoma, nonpapillary 26.8 VEGFD TSC2 TSC1 TFE3 S100A1 PRCC
4 childhood multilocular cystic kidney neoplasm 11.2
5 renal pelvis transitional cell carcinoma 10.6 MTOR KRT7
6 fallopian tube leiomyoma 10.6 TSC2 MME
7 fallopian tube benign neoplasm 10.6 TSC2 MME
8 vaginal adenosarcoma 10.6 MTOR MME
9 vaginal carcinosarcoma 10.6 MTOR MME
10 lissencephaly with cerebellar hypoplasia 10.6 TSC2 TSC1
11 subareolar duct papillomatosis 10.5 MME KRT7
12 nipple neoplasm 10.5 MME KRT7
13 prostate lymphoma 10.5 MME AMACR
14 ovarian mesodermal adenosarcoma 10.5 PAX8 KRT7
15 cervical adenoma malignum 10.5 MME KRT7
16 focal cortical dysplasia, type ii 10.5 TSC2 TSC1 MTOR
17 anal canal paget's disease 10.5 MLANA KRT7
18 anal paget's disease 10.5 MLANA KRT7
19 cervix endometriosis 10.5 PAX2 MME
20 rete testis neoplasm 10.5 PAX8 KRT7
21 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.5 TSC2 TSC1 FLCN
22 eccrine papillary adenocarcinoma 10.5 MME KRT7
23 rete testis adenocarcinoma 10.5 PAX8 KRT7
24 benign ependymoma 10.5 TSC2 TSC1 MTOR
25 ovarian seromucinous carcinoma 10.5 PAX8 KRT7
26 renal pelvis adenocarcinoma 10.5 PAX8 KRT7
27 melanoacanthoma 10.5 MTOR MLANA
28 urethra adenocarcinoma 10.5 PAX8 PAX2
29 prostatic acinar adenocarcinoma 10.5 PAX8 AMACR
30 rete testis adenoma 10.5 PAX8 PAX2
31 multilocular clear cell renal cell carcinoma 10.5 FLCN CDH16
32 metanephric adenoma 10.5 PRCC KRT7 AMACR
33 female urethral cancer 10.5 MME KRT7 AMACR
34 urethra cancer 10.5 PAX8 PAX2
35 glandular cystitis 10.5 MME KRT7 AMACR
36 cervical serous adenocarcinoma 10.4 MME MLANA
37 eccrine sweat gland neoplasm 10.4 MME KRT7
38 benign mesothelioma 10.4 PAX8 KRT7
39 sensory organ benign neoplasm 10.4 MLANA KRT7
40 urethral diverticulum 10.4 PAX8 KRT7 AMACR
41 pancreatic mucinous cystadenoma 10.4 MME KRT7
42 mixed epithelial stromal tumour 10.4 MME MEST KRT7
43 sarcomatoid squamous cell skin carcinoma 10.4 MME MLANA
44 renal cell carcinoma, xp11-associated 10.4 TFE3 PRCC
45 laryngeal small cell carcinoma 10.4 MLANA KRT7
46 large cell acanthoma 10.4 MTOR MLANA KRT7
47 epididymal neoplasm 10.4 PAX2 MME KRT7
48 childhood kidney cell carcinoma 10.4 TFE3 PRCC
49 respiratory system benign neoplasm 10.4 TSC2 MLANA KRT7
50 angiolipoma 10.4 MLANA FLCN

Graphical network of the top 20 diseases related to Kidney Benign Neoplasm:



Diseases related to Kidney Benign Neoplasm

Symptoms & Phenotypes for Kidney Benign Neoplasm

MGI Mouse Phenotypes related to Kidney Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.28 DICER1 FLCN KIT KRT7 MEST MME
2 cardiovascular system MP:0005385 10.23 DICER1 FLCN KIT MEST MTOR PAX2
3 growth/size/body region MP:0005378 10.15 AMACR DICER1 FLCN KIT MEST MTOR
4 homeostasis/metabolism MP:0005376 10.13 AMACR DICER1 FLCN KIT KRT7 MME
5 embryo MP:0005380 10.1 DICER1 FLCN KIT MEST MTOR PAX2
6 mortality/aging MP:0010768 10.07 AMACR DICER1 FLCN KIT MEST MTOR
7 normal MP:0002873 9.81 DICER1 KIT MTOR PAX8 RHEB S100A1
8 pigmentation MP:0001186 9.35 KIT MLANA PAX2 TFE3 TSC1
9 renal/urinary system MP:0005367 9.28 DICER1 FLCN KIT KRT7 MTOR PAX2

Drugs & Therapeutics for Kidney Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Kidney Benign Neoplasm

Genetic Tests for Kidney Benign Neoplasm

Anatomical Context for Kidney Benign Neoplasm

MalaCards organs/tissues related to Kidney Benign Neoplasm:

40
Kidney, Breast, Testis, Thymus, Heart, Liver, Thyroid

Publications for Kidney Benign Neoplasm

Variations for Kidney Benign Neoplasm

Expression for Kidney Benign Neoplasm

Search GEO for disease gene expression data for Kidney Benign Neoplasm.

Pathways for Kidney Benign Neoplasm

Pathways related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.93 VEGFD TSC2 TSC1 RHEB MTOR KIT
2
Show member pathways
12.87 VEGFD TSC2 TSC1 RHEB MTOR KIT
3
Show member pathways
12.75 TSC2 RHEB PAX8 MTOR KIT
4
Show member pathways
12.31 TSC2 TSC1 RHEB MTOR
5
Show member pathways
12.3 TSC2 TSC1 RHEB MTOR FLCN
6
Show member pathways
12.28 TSC2 TSC1 RHEB MTOR
7
Show member pathways
12.26 TSC2 TSC1 RHEB MTOR
8
Show member pathways
12.11 TSC2 TSC1 RHEB MTOR KIT
9 12.04 TSC2 TSC1 RHEB MTOR
10 12.01 TSC2 TSC1 RHEB MTOR
11
Show member pathways
11.99 TSC2 TSC1 RHEB MTOR
12
Show member pathways
11.97 TSC2 TSC1 RHEB MTOR
13 11.89 TSC2 TSC1 RHEB MTOR
14 11.84 TSC2 TSC1 MTOR FLCN DICER1
15 11.74 TSC2 TSC1 RHEB
16 11.49 TSC2 TSC1 RHEB MTOR
17 11.45 TSC2 TSC1 MTOR
18 11.28 TSC2 TSC1 MTOR
19 11.06 TSC2 RHEB MTOR
20 11.03 TSC2 TSC1 RHEB MTOR
21 10.98 TSC2 RHEB MTOR
22 10.82 PAX8 PAX2
23 10.44 TSC2 TSC1 RHEB MTOR

GO Terms for Kidney Benign Neoplasm

Cellular components related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 TSC1-TSC2 complex GO:0033596 8.62 TSC2 TSC1

Biological processes related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 neural tube closure GO:0001843 9.76 TSC2 TSC1 PAX2
2 negative regulation of cold-induced thermogenesis GO:0120163 9.69 TFE3 RHEB FLCN
3 urogenital system development GO:0001655 9.62 PAX8 PAX2
4 regulation of osteoclast differentiation GO:0045670 9.61 TFE3 MTOR
5 negative regulation of programmed cell death GO:0043069 9.61 PAX2 KIT
6 negative regulation of macroautophagy GO:0016242 9.6 TSC1 MTOR
7 mesonephros development GO:0001823 9.59 PAX8 PAX2
8 anoikis GO:0043276 9.58 TSC2 MTOR
9 negative regulation of TOR signaling GO:0032007 9.58 TSC2 TSC1 FLCN
10 negative regulation of cell size GO:0045792 9.57 TSC1 MTOR
11 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.56 PAX8 PAX2
12 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.55 PAX8 PAX2
13 pronephros development GO:0048793 9.54 PAX8 PAX2
14 metanephric epithelium development GO:0072207 9.52 PAX8 PAX2
15 metanephric nephron tubule formation GO:0072289 9.49 PAX8 PAX2
16 metanephric distal convoluted tubule development GO:0072221 9.48 PAX8 PAX2
17 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.46 PAX8 PAX2
18 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.43 PAX8 PAX2
19 positive regulation of metanephric DCT cell differentiation GO:2000594 9.37 PAX8 PAX2
20 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.32 PAX8 PAX2
21 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.26 PAX8 PAX2
22 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.16 PAX8 PAX2
23 pronephric field specification GO:0039003 8.96 PAX8 PAX2
24 regulation of TOR signaling GO:0032006 8.8 ROS1 RHEB FLCN

Sources for Kidney Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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