MCID: KDN016
MIFTS: 30

Kidney Benign Neoplasm

Categories: Cancer diseases, Nephrological diseases
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Aliases & Classifications for Kidney Benign Neoplasm

MalaCards integrated aliases for Kidney Benign Neoplasm:

Name: Kidney Benign Neoplasm 11 14
Renal and Ureteral Tumor 11
Benign Kidney Neoplasm 16

Classifications:



External Ids:

Disease Ontology 11 DOID:3116
NCIt 49 C7514
ICD10 31 D30.0
UMLS 71 C1334323

Summaries for Kidney Benign Neoplasm

MalaCards based summary: Kidney Benign Neoplasm, also known as renal and ureteral tumor, is related to nephroma and childhood multilocular cystic kidney neoplasm. An important gene associated with Kidney Benign Neoplasm is TSC2 (TSC Complex Subunit 2), and among its related pathways/superpathways are p70S6K Signaling and PI3K-Akt signaling pathway. The drug Pyruvate has been mentioned in the context of this disorder. Affiliated tissues include kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Kidney Benign Neoplasm

Diseases related to Kidney Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 296)
# Related Disease Score Top Affiliating Genes
1 nephroma 31.4 WT1 TFE3 NTRK3 MME KIT ETV6
2 childhood multilocular cystic kidney neoplasm 11.1
3 male urethral cancer 10.5 KRT7 AMACR
4 seminal vesicle adenocarcinoma 10.4 KRT7 AMACR
5 prostatic urethral cancer 10.4 KRT7 AMACR
6 fallopian tube leiomyoma 10.4 TSC2 MME
7 fallopian tube benign neoplasm 10.4 TSC2 MME
8 bladder urachal carcinoma 10.4 KRT7 AMACR
9 urachus cancer 10.4 KRT7 AMACR
10 cystitis cystica 10.4 KRT7 AMACR
11 mucinous cystadenofibroma 10.4 PAX8 KRT7
12 liver lipoma 10.4 TSC2 TSC1
13 vaginal adenosarcoma 10.4 MTOR MME
14 urethra cancer 10.4 PAX8 KRT7
15 vulvar sebaceous carcinoma 10.4 PAX8 KRT7
16 rete testis neoplasm 10.4 PAX8 KRT7
17 endometrial squamous cell carcinoma 10.4 PAX8 KRT7
18 prostate lymphoma 10.4 MME AMACR
19 rete testis adenocarcinoma 10.4 PAX8 KRT7
20 subareolar duct papillomatosis 10.4 MME KRT7
21 nipple benign neoplasm 10.4 MME KRT7
22 renal pelvis adenocarcinoma 10.4 PAX8 KRT7
23 microinvasive cervical squamous cell carcinoma 10.4 WT1 KRT7
24 cowden syndrome 4 10.4 TSC2 FLCN
25 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.4 TSC2 TSC1
26 benign breast adenomyoepithelioma 10.4 MME KRT7
27 vaginal carcinosarcoma 10.4 MME KRT7
28 prostatic acinar adenocarcinoma 10.4 PAX8 AMACR
29 anal canal paget's disease 10.4 MLANA KRT7
30 anal paget's disease 10.4 MLANA KRT7
31 ovarian endodermal sinus tumor 10.4 PAX8 KRT7
32 mixed epithelial stromal tumour 10.4 MME KRT7
33 wolffian duct adenocarcinoma 10.4 PAX8 MME
34 malignant biphasic mesothelioma 10.4 WT1 KRT7
35 krukenberg carcinoma 10.4 PAX8 KRT7
36 vulval paget's disease 10.4 MLANA KRT7
37 urethral diverticulum 10.4 PAX8 KRT7
38 peritoneal serous adenocarcinoma 10.4 WT1 PAX8
39 botryoid rhabdomyosarcoma 10.4 WT1 DICER1
40 focal cortical dysplasia, type ii 10.4 TSC2 TSC1 MTOR
41 ovarian primitive germ cell tumor 10.4 PAX8 KRT7
42 fallopian tube adenocarcinoma 10.4 WT1 PAX8
43 corneal dystrophy, fleck 10.4 TSC2 TSC1 MTOR
44 breast metaplastic carcinoma 10.4 MME KRT7
45 internal hemorrhoid 10.4 MLANA KRT7
46 gallbladder signet ring cell adenocarcinoma 10.4 PAX8 KRT7
47 ovarian wilms' cancer 10.4 WT1 MLANA
48 pericardial mesothelioma 10.4 WT1 KRT7
49 female urethral cancer 10.4 MME KRT7 AMACR
50 laryngeal adenoid cystic carcinoma 10.4 KRT7 KIT

Graphical network of the top 20 diseases related to Kidney Benign Neoplasm:



Diseases related to Kidney Benign Neoplasm

Symptoms & Phenotypes for Kidney Benign Neoplasm

GenomeRNAi Phenotypes related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

25 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.7 MTOR RHEB
2 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.7 TSC1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.7 TSC1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.7 NTRK3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.7 NTRK3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.7 KIT NTRK3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.7 KIT
8 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.7 KIT
9 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.7 KIT NTRK3
10 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.7 NTRK3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.7 NTRK3 TSC1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.7 MTOR NTRK3
13 Increased shRNA abundance (Z-score > 2) GR00366-A-61 9.7 KIT
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.7 RHEB
15 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.7 KIT MTOR NTRK3
16 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.7 KIT
17 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.7 KIT

MGI Mouse Phenotypes related to Kidney Benign Neoplasm:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 AMACR DICER1 ETV6 FLCN KIT KRT7
2 normal MP:0002873 10.24 DICER1 ETV6 KIT MTOR NTRK3 PAX8
3 growth/size/body region MP:0005378 10.21 AMACR DICER1 ETV6 FLCN KIT MTOR
4 renal/urinary system MP:0005367 10.2 DICER1 ETV6 FLCN KIT KRT7 MTOR
5 neoplasm MP:0002006 10.11 DICER1 ETV6 FLCN KIT TSC1 TSC2
6 no phenotypic analysis MP:0003012 10.08 DICER1 ETV6 KIT MLANA MTOR NTRK3
7 liver/biliary system MP:0005370 10.03 AMACR DICER1 ETV6 KIT MME TSC1
8 endocrine/exocrine gland MP:0005379 10.02 DICER1 ETV6 KIT MTOR PAX2 PAX8
9 embryo MP:0005380 10 DICER1 ETV6 FLCN KIT MTOR PAX2
10 cellular MP:0005384 9.97 DICER1 ETV6 FLCN KIT KRT7 MME
11 cardiovascular system MP:0005385 9.77 DICER1 ETV6 FLCN KIT MTOR NTRK3
12 mortality/aging MP:0010768 9.5 AMACR DICER1 ETV6 FLCN KIT MTOR

Drugs & Therapeutics for Kidney Benign Neoplasm

Drugs for Kidney Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pyruvate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hyperpolarized 13C Pyruvate Metabolic MRI to Predict Renal Tumor Aggressiveness Recruiting NCT04258462 Phase 2 Hyperpolarized Carbon C 13 Pyruvate

Search NIH Clinical Center for Kidney Benign Neoplasm

Genetic Tests for Kidney Benign Neoplasm

Anatomical Context for Kidney Benign Neoplasm

Organs/tissues related to Kidney Benign Neoplasm:

MalaCards : Kidney

Publications for Kidney Benign Neoplasm

Variations for Kidney Benign Neoplasm

Expression for Kidney Benign Neoplasm

Search GEO for disease gene expression data for Kidney Benign Neoplasm.

Pathways for Kidney Benign Neoplasm

Pathways related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.9 VEGFD TSC2 TSC1 RHEB NTRK3 MTOR
2
Show member pathways
12.88 VEGFD TSC2 TSC1 RHEB MTOR KIT
3 12.46 VEGFD TSC2 TSC1 RHEB MTOR KIT
4
Show member pathways
12.41 TSC2 TSC1 RHEB MTOR
5
Show member pathways
12.18 TSC2 TSC1 RHEB MTOR
6
Show member pathways
12.11 MTOR NTRK3 RHEB TSC1 TSC2
7
Show member pathways
12.09 TSC2 TSC1 RHEB MTOR
8 12.07 MTOR RHEB TSC1 TSC2
9
Show member pathways
12.04 TSC2 TSC1 RHEB MTOR
10 12.02 TSC2 TSC1 RHEB MTOR
11
Show member pathways
12.01 TSC2 TSC1 MTOR FLCN DICER1
12
Show member pathways
11.98 TSC2 TSC1 RHEB MTOR
13
Show member pathways
11.96 TSC2 TSC1 RHEB MTOR
14
Show member pathways
11.86 TSC2 TSC1 RHEB MTOR
15 11.77 TSC2 TSC1 RHEB
16 11.7 TSC2 TSC1 RHEB MTOR
17 11.66 WT1 PAX2 MME
18 11.66 TSC2 TSC1 RHEB MTOR
19 11.62 MTOR RHEB TSC1 TSC2
20 11.59 TSC2 TSC1 MTOR
21 11.42 TSC2 TSC1 RHEB MTOR
22 11.31 TSC2 TSC1 MTOR
23
Show member pathways
11.23 TSC2 TSC1 RHEB MTOR
24 11.19 TSC2 RHEB MTOR
25
Show member pathways
11.11 TSC2 TSC1 RHEB MTOR DICER1
26 11.01 TSC2 TSC1 MTOR
27 10.94 TSC2 TSC1 RHEB MTOR

GO Terms for Kidney Benign Neoplasm

Cellular components related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 TSC1-TSC2 complex GO:0033596 8.92 TSC2 TSC1

Biological processes related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 10.13 WT1 TSC1 PAX8 MME
2 protein kinase B signaling GO:0043491 10.07 TSC2 PAX2 FLCN
3 negative regulation of cold-induced thermogenesis GO:0120163 10.04 TFE3 RHEB FLCN
4 branching involved in ureteric bud morphogenesis GO:0001658 10.02 WT1 PAX8 PAX2
5 negative regulation of TOR signaling GO:0032007 9.91 TSC2 TSC1 FLCN
6 metanephric mesenchyme development GO:0072075 9.9 WT1 PAX2
7 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.88 PAX8 PAX2
8 cellular response to gonadotropin stimulus GO:0071371 9.88 WT1 PAX8
9 pronephros development GO:0048793 9.86 PAX2 PAX8
10 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.84 PAX8 PAX2
11 metanephric S-shaped body morphogenesis GO:0072284 9.81 PAX8 WT1
12 metanephric nephron tubule formation GO:0072289 9.8 PAX8 PAX2
13 metanephric distal convoluted tubule development GO:0072221 9.78 PAX8 PAX2
14 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.76 PAX8 PAX2
15 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.71 PAX8 PAX2
16 pronephric field specification GO:0039003 9.67 PAX2 PAX8
17 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.62 PAX2 PAX8
18 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.56 PAX2 PAX8
19 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.46 PAX2 PAX8
20 positive regulation of metanephric DCT cell differentiation GO:2000594 9.26 PAX2 PAX8
21 metanephric epithelium development GO:0072207 9.1 WT1 PAX8 PAX2

Sources for Kidney Benign Neoplasm

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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