MCID: KDN016
MIFTS: 30

Kidney Benign Neoplasm

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Kidney Benign Neoplasm

MalaCards integrated aliases for Kidney Benign Neoplasm:

Name: Kidney Benign Neoplasm 12 15
Renal and Ureteral Tumor 12
Benign Kidney Neoplasm 17

Classifications:



External Ids:

Disease Ontology 12 DOID:3116
NCIt 50 C7514
ICD10 32 D30.0
UMLS 71 C1334323

Summaries for Kidney Benign Neoplasm

MalaCards based summary : Kidney Benign Neoplasm, also known as renal and ureteral tumor, is related to nephroma and childhood multilocular cystic kidney neoplasm. An important gene associated with Kidney Benign Neoplasm is TSC2 (TSC Complex Subunit 2), and among its related pathways/superpathways are p70S6K Signaling and Angiopoietin Like Protein 8 Regulatory Pathway. The drug pyruvate has been mentioned in the context of this disorder. Affiliated tissues include kidney, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Kidney Benign Neoplasm

Diseases related to Kidney Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
# Related Disease Score Top Affiliating Genes
1 nephroma 31.2 WT1 TFE3 NTRK3 MME ETV6 DICER1
2 childhood multilocular cystic kidney neoplasm 11.1
3 fallopian tube leiomyoma 10.4 TSC2 MME
4 fallopian tube benign neoplasm 10.4 TSC2 MME
5 vaginal adenosarcoma 10.4 MTOR MME
6 vaginal carcinosarcoma 10.4 MTOR MME
7 lissencephaly with cerebellar hypoplasia 10.4 TSC2 TSC1
8 subareolar duct papillomatosis 10.4 MME KRT7
9 cervical mucinous adenocarcinoma 10.4 MME KRT7
10 nipple benign neoplasm 10.4 MME KRT7
11 pancreatic serous cystadenocarcinoma 10.4 MME KRT7
12 mixed epithelial stromal tumour 10.4 MME KRT7
13 rete testis neoplasm 10.4 PAX8 KRT7
14 microinvasive cervical squamous cell carcinoma 10.4 WT1 KRT7
15 rete testis adenocarcinoma 10.4 PAX8 KRT7
16 glandular cystitis 10.4 KRT7 AMACR
17 breast metaplastic carcinoma 10.4 MME KRT7
18 bartholin's gland carcinoma 10.4 PAX8 KRT7
19 microcystic stromal tumor 10.4 WT1 DICER1
20 renal pelvis adenocarcinoma 10.4 PAX8 KRT7
21 krukenberg carcinoma 10.4 PAX8 KRT7
22 orbital cellulitis 10.4 MME KRT7
23 acute orbital inflammation 10.4 MME KRT7
24 anal canal paget's disease 10.4 MLANA KRT7
25 anal paget's disease 10.4 MLANA KRT7
26 prostatic acinar adenocarcinoma 10.4 PAX8 AMACR
27 heart cancer 10.4 TSC2 TSC1 MTOR
28 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.4 TSC2 TSC1 FLCN
29 corneal dystrophy, fleck 10.4 TSC2 TSC1 MTOR
30 pancreatic mucinous cystadenoma 10.4 MME KRT7
31 cervix endometriosis 10.4 PAX2 MME
32 melanoacanthoma 10.4 MLANA KRT7
33 pericardium cancer 10.4 WT1 KRT7
34 vulval paget's disease 10.4 MLANA KRT7
35 female urethral cancer 10.4 MME KRT7 AMACR
36 sensory organ benign neoplasm 10.4 MLANA KRT7
37 rete testis adenoma 10.3 PAX8 PAX2
38 squamous papillomatosis 10.3 MME KRT7
39 colon leiomyosarcoma 10.3 WT1 PAX8
40 reproductive organ benign neoplasm 10.3 TSC2 MME KRT7
41 papillary adenoma 10.3 TFE3 KRT7 AMACR
42 large cell acanthoma 10.3 MLANA KRT7
43 schwannoma of twelfth cranial nerve 10.3 MLANA KRT7
44 pilar sheath acanthoma 10.3 MME KRT7 FLCN
45 hypoglossal nerve disease 10.3 MLANA KRT7
46 kidney sarcoma 10.3 WT1 DICER1
47 urethral diverticulum 10.3 PAX8 KRT7 AMACR
48 adenofibroma 10.3 WT1 MME KRT7
49 ovarian endometrioid stromal sarcoma 10.3 WT1 MME
50 sarcomatoid squamous cell skin carcinoma 10.3 MME MLANA

Graphical network of the top 20 diseases related to Kidney Benign Neoplasm:



Diseases related to Kidney Benign Neoplasm

Symptoms & Phenotypes for Kidney Benign Neoplasm

GenomeRNAi Phenotypes related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.74 MTOR
2 Decreased viability GR00055-A-2 9.74 MTOR
3 Decreased viability GR00221-A-1 9.74 MTOR RHEB
4 Decreased viability GR00221-A-2 9.74 NTRK3 TSC1
5 Decreased viability GR00221-A-3 9.74 TSC1
6 Decreased viability GR00221-A-4 9.74 MTOR NTRK3
7 Decreased viability GR00240-S-1 9.74 PAX8
8 Decreased viability GR00249-S 9.74 AMACR B3GAT1 CDH16 S100A1
9 Decreased viability GR00301-A 9.74 TSC1
10 Decreased viability GR00342-S-1 9.74 MTOR
11 Decreased viability GR00342-S-2 9.74 MTOR
12 Decreased viability GR00381-A-1 9.74 CDH16 WT1
13 Decreased viability GR00386-A-1 9.74 B3GAT1 CDH16 RHEB S100A1 TFE3
14 Decreased viability GR00402-S-2 9.74 B3GAT1 PAX8

MGI Mouse Phenotypes related to Kidney Benign Neoplasm:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.34 DICER1 ETV6 FLCN MME MTOR NTRK3
2 cellular MP:0005384 10.29 DICER1 ETV6 FLCN KRT7 MME MTOR
3 growth/size/body region MP:0005378 10.22 AMACR DICER1 ETV6 FLCN MTOR NTRK3
4 homeostasis/metabolism MP:0005376 10.21 AMACR DICER1 ETV6 FLCN KRT7 MME
5 mortality/aging MP:0010768 10.2 AMACR B3GAT1 DICER1 ETV6 FLCN MTOR
6 embryo MP:0005380 10.16 DICER1 ETV6 FLCN MTOR PAX2 PAX8
7 endocrine/exocrine gland MP:0005379 10.09 DICER1 ETV6 MTOR PAX2 PAX8 RHEB
8 neoplasm MP:0002006 9.8 DICER1 ETV6 FLCN TSC1 TSC2 VEGFD
9 no phenotypic analysis MP:0003012 9.7 DICER1 ETV6 MLANA MTOR NTRK3 PAX8
10 normal MP:0002873 9.7 DICER1 ETV6 MTOR NTRK3 PAX8 RHEB
11 renal/urinary system MP:0005367 9.28 DICER1 FLCN KRT7 MTOR PAX2 PAX8

Drugs & Therapeutics for Kidney Benign Neoplasm

Drugs for Kidney Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 pyruvate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hyperpolarized 13C Pyruvate Metabolic MRI to Predict Renal Tumor Aggressiveness Recruiting NCT04258462 Phase 2 Hyperpolarized Carbon C 13 Pyruvate

Search NIH Clinical Center for Kidney Benign Neoplasm

Genetic Tests for Kidney Benign Neoplasm

Anatomical Context for Kidney Benign Neoplasm

MalaCards organs/tissues related to Kidney Benign Neoplasm:

40
Kidney

Publications for Kidney Benign Neoplasm

Variations for Kidney Benign Neoplasm

Expression for Kidney Benign Neoplasm

Search GEO for disease gene expression data for Kidney Benign Neoplasm.

Pathways for Kidney Benign Neoplasm

Pathways related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.93 VEGFD TSC2 TSC1 RHEB NTRK3 MTOR
2
Show member pathways
12.41 TSC2 TSC1 RHEB MTOR
3
Show member pathways
12.37 TSC2 TSC1 RHEB MTOR
4
Show member pathways
12.3 TSC2 TSC1 RHEB MTOR
5
Show member pathways
12.3 TSC2 TSC1 RHEB MTOR FLCN
6
Show member pathways
12.28 TSC2 TSC1 RHEB MTOR
7
Show member pathways
12.27 TSC2 TSC1 RHEB MTOR
8 12.14 WT1 TFE3 PAX8 ETV6
9
Show member pathways
12.06 TSC2 TSC1 RHEB NTRK3 MTOR
10 12.03 TSC2 TSC1 RHEB MTOR
11 12.01 TSC2 TSC1 RHEB MTOR
12
Show member pathways
11.99 TSC2 TSC1 RHEB MTOR
13 11.89 TSC2 TSC1 RHEB MTOR
14 11.84 TSC2 TSC1 MTOR FLCN DICER1
15 11.74 TSC2 TSC1 RHEB
16 11.62 WT1 PAX2 MME
17
Show member pathways
11.62 TSC2 TSC1 RHEB MTOR
18 11.49 TSC2 TSC1 RHEB MTOR
19 11.45 TSC2 TSC1 MTOR
20 11.29 TSC2 TSC1 MTOR
21 11.06 TSC2 RHEB MTOR
22 11.03 TSC2 TSC1 RHEB MTOR
23 10.98 TSC2 RHEB MTOR
24 10.82 PAX8 PAX2
25 10.44 TSC2 TSC1 RHEB MTOR

GO Terms for Kidney Benign Neoplasm

Cellular components related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 TSC1-TSC2 complex GO:0033596 8.62 TSC2 TSC1

Biological processes related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.88 VEGFD NTRK3 MTOR FLCN
2 neural tube closure GO:0001843 9.8 TSC2 TSC1 PAX2
3 response to nutrient levels GO:0031667 9.79 TSC1 PAX2 MTOR
4 kidney development GO:0001822 9.76 WT1 TSC1 PAX8 MME
5 negative regulation of cold-induced thermogenesis GO:0120163 9.71 TFE3 RHEB FLCN
6 urogenital system development GO:0001655 9.65 PAX8 PAX2
7 branching involved in ureteric bud morphogenesis GO:0001658 9.65 WT1 PAX8 PAX2
8 regulation of osteoclast differentiation GO:0045670 9.64 TFE3 MTOR
9 negative regulation of macroautophagy GO:0016242 9.64 TSC1 MTOR
10 mesonephros development GO:0001823 9.63 PAX8 PAX2
11 anoikis GO:0043276 9.62 TSC2 MTOR
12 negative regulation of cell size GO:0045792 9.61 TSC1 MTOR
13 mesenchymal to epithelial transition GO:0060231 9.61 WT1 PAX2
14 negative regulation of TOR signaling GO:0032007 9.61 TSC2 TSC1 FLCN
15 metanephric mesenchyme development GO:0072075 9.6 WT1 PAX2
16 cellular response to gonadotropin stimulus GO:0071371 9.59 WT1 PAX8
17 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.58 PAX8 PAX2
18 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.57 PAX8 PAX2
19 pronephros development GO:0048793 9.56 PAX8 PAX2
20 metanephric S-shaped body morphogenesis GO:0072284 9.55 WT1 PAX8
21 metanephric nephron tubule formation GO:0072289 9.52 PAX8 PAX2
22 metanephric distal convoluted tubule development GO:0072221 9.51 PAX8 PAX2
23 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.49 PAX8 PAX2
24 positive regulation of metanephric DCT cell differentiation GO:2000594 9.4 PAX8 PAX2
25 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.37 PAX8 PAX2
26 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.32 PAX8 PAX2
27 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.26 PAX8 PAX2
28 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.16 PAX8 PAX2
29 pronephric field specification GO:0039003 8.96 PAX8 PAX2
30 metanephric epithelium development GO:0072207 8.8 WT1 PAX8 PAX2

Molecular functions related to Kidney Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 WT1 VEGFD TSC2 TSC1 TFE3 S100A1
2 transcription regulatory region sequence-specific DNA binding GO:0000976 8.92 WT1 TFE3 PAX8 PAX2

Sources for Kidney Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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