MCID: KDN001
MIFTS: 29

Kidney Cortex Necrosis

Categories: Nephrological diseases

Aliases & Classifications for Kidney Cortex Necrosis

MalaCards integrated aliases for Kidney Cortex Necrosis:

Name: Kidney Cortex Necrosis 12 44 15 73
Renal Cortical Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2973
ICD10 33 N17.1
MeSH 44 D007673
SNOMED-CT 68 444691002 45456005
UMLS 73 C0022656

Summaries for Kidney Cortex Necrosis

MalaCards based summary : Kidney Cortex Necrosis, also known as renal cortical necrosis, is related to anuria and antiphospholipid syndrome. An important gene associated with Kidney Cortex Necrosis is HADHA (Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Alpha), and among its related pathways/superpathways are Metabolism and Carbon metabolism. The drugs Tranexamic Acid and Antifibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, cortex and placenta.

Wikipedia : 76 Renal cortical necrosis (RCN) is a rare cause of acute kidney failure. The condition is \"usually caused... more...

Related Diseases for Kidney Cortex Necrosis

Diseases related to Kidney Cortex Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 anuria 9.8
2 antiphospholipid syndrome 9.8
3 waterhouse-friderichsen syndrome 9.8
4 meningococcemia 9.8
5 systemic lupus erythematosus 9.7
6 malaria 9.7
7 end stage renal failure 9.7
8 glomerulonephritis 9.7
9 leukemia 9.7
10 nephrosclerosis 9.7
11 shigellosis 9.7
12 hemolytic-uremic syndrome 9.7
13 plasmodium vivax malaria 9.7
14 crescentic glomerulonephritis 9.7
15 eclampsia 9.7
16 cryoglobulinemia 9.7
17 purpura 9.7
18 shwartzman phenomenon 9.7
19 monocytic leukemia 9.7
20 lupus erythematosus 9.7
21 bile duct disease 9.6 GPT HADHA
22 hellp syndrome 9.5 GPT HADHA
23 liver disease 9.1 GPT HADHA
24 trehalase deficiency 9.1 HADHA MMACHC TYR

Graphical network of the top 20 diseases related to Kidney Cortex Necrosis:



Diseases related to Kidney Cortex Necrosis

Symptoms & Phenotypes for Kidney Cortex Necrosis

Drugs & Therapeutics for Kidney Cortex Necrosis

Drugs for Kidney Cortex Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 3 1197-18-8 5526
2 Antifibrinolytic Agents Phase 3
3 Coagulants Phase 3
4 Hemostatics Phase 3
5 Pharmaceutical Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety Study of XP12B in Women With Menorrhagia Completed NCT00113568 Phase 3 Tranexamic acid tablets (XP12B)
2 A Study of CSL112 in Adults With Moderate Renal Impairment and Acute Myocardial Infarction Completed NCT02742103 Phase 2
3 Regional and Long Term Outcomes of Acute Kidney Injury in England From 2000 to 2015 - A National Database Study Completed NCT02675296
4 Predictive Value of PIIINP and Urinary NGAL in Renal Function Recovery Completed NCT02889575

Search NIH Clinical Center for Kidney Cortex Necrosis

Cochrane evidence based reviews: kidney cortex necrosis

Genetic Tests for Kidney Cortex Necrosis

Anatomical Context for Kidney Cortex Necrosis

MalaCards organs/tissues related to Kidney Cortex Necrosis:

41
Kidney, Cortex, Placenta, Pituitary, Monocytes

Publications for Kidney Cortex Necrosis

Articles related to Kidney Cortex Necrosis:

(show all 16)
# Title Authors Year
1
Renal cortical necrosis: A rare complication of Plasmodium vivax malaria. ( 25484536 )
2014
2
Bilateral renal cortical necrosis with end-stage renal failure following envenoming by Proatheris superciliaris: a case report. ( 24709757 )
2014
3
Postoperative hemolytic uremic syndrome with renal cortical necrosis following laparoscopic hemicolectomy. ( 23560430 )
2013
4
Post-partum bilateral renal cortical necrosis in antiphospholipid syndrome and systemic lupus erythematosus. ( 23640629 )
2013
5
Bilateral acute renal cortical necrosis in SLE-associated antiphospholipid syndrome. ( 21514023 )
2011
6
The Case. Generalized petechiae and acute renal failure: bilateral renal cortical necrosis in meningococcemia. ( 18516063 )
2008
7
Type III cryoglobulinemia complicated by renal cortical necrosis. ( 15861340 )
2005
8
Waterhouse-Friderichsen syndrome and bilateral renal cortical necrosis in meningococcal sepsis. ( 10922319 )
2000
9
Erythropoietin deficiency in acute crescentic glomerulonephritis and in total bilateral renal cortical necrosis. ( 2026990 )
1991
10
An animal model of haemolytic--uraemic syndrome in shigellosis: lipopolysaccharides of Shigella dysenteriae I and S. flexneri produce leucocyte-mediated renal cortical necrosis in rabbits. ( 3882120 )
1985
11
Bilateral renal cortical necrosis following monocytic leukemia. ( 1066871 )
1975
12
Two cases of gross renal cortical necrosis in pregnancy with severe oliguria and anuria for 116 and 79 days respectively; clinical course, roentgenological studies of the kidneys (size, outlines and calcifications), and post-mortem findings. ( 13544858 )
1958
13
Gross bilateral renal cortical necrosis during long periods of oliguria-anuria; roentgenologic observations in two cases. ( 13497791 )
1957
14
The pathologic anatomy of eclampsia, bilateral renal cortical necrosis, pituitary necrosis, and other acute fatal complications of pregnancy, and its possible relationship to the generalized Shwartzman phenomenon. ( 13080345 )
1953
15
Unilateral renal cortical necrosis and unilateral benign and malignant nephrosclerosis, associated with contralateral renal artery occlusion: report of a case. ( 14789332 )
1951
16
Experimental study of purpuric meningococcemia in relation to the Shwartzmann phenomenon; with discussion of meningococcic purpura, the Waterhouse-Friderichsen syndrome and bilateral renal cortical necrosis. ( 20284509 )
1947

Variations for Kidney Cortex Necrosis

Expression for Kidney Cortex Necrosis

Search GEO for disease gene expression data for Kidney Cortex Necrosis.

Pathways for Kidney Cortex Necrosis

Pathways related to Kidney Cortex Necrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 CYP2B6 GPT HADHA MMACHC TYR
2
Show member pathways
11.48 GPT HADHA
3 9.74 CYP2B6 HADHA

GO Terms for Kidney Cortex Necrosis

Biological processes related to Kidney Cortex Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 8.92 CYP2B6 HADHA MMACHC TYR

Molecular functions related to Kidney Cortex Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monooxygenase activity GO:0004497 8.96 CYP2B6 TYR
2 oxidoreductase activity GO:0016491 8.92 CYP2B6 HADHA MMACHC TYR

Sources for Kidney Cortex Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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