MCID: KDN001
MIFTS: 29

Kidney Cortex Necrosis

Categories: Nephrological diseases

Aliases & Classifications for Kidney Cortex Necrosis

MalaCards integrated aliases for Kidney Cortex Necrosis:

Name: Kidney Cortex Necrosis 12 44 15 73
Renal Cortical Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2973
ICD10 33 N17.1
MeSH 44 D007673
SNOMED-CT 68 45456005
UMLS 73 C0022656

Summaries for Kidney Cortex Necrosis

MalaCards based summary : Kidney Cortex Necrosis, also known as renal cortical necrosis, is related to shwartzman phenomenon and pancreatitis. An important gene associated with Kidney Cortex Necrosis is HADHA (Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Alpha), and among its related pathways/superpathways is Carbon metabolism. The drugs Tranexamic Acid and Antifibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, cortex and placenta, and related phenotype is homeostasis/metabolism.

Wikipedia : 76 Renal cortical necrosis (RCN) is a rare cause of acute kidney failure. The condition is "usually caused... more...

Related Diseases for Kidney Cortex Necrosis

Diseases related to Kidney Cortex Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 shwartzman phenomenon 10.3
2 pancreatitis 10.2
3 acute pancreatitis 10.2
4 antiphospholipid syndrome 10.1
5 systemic lupus erythematosus 10.0
6 hemolytic-uremic syndrome 10.0
7 lupus erythematosus 10.0
8 malaria 9.9
9 glomerulonephritis 9.9
10 hydronephrosis 9.9
11 anuria 9.9
12 waterhouse-friderichsen syndrome 9.9
13 meningococcemia 9.9
14 fatty liver disease, nonalcoholic 1 9.8 GPT HADHA
15 end stage renal failure 9.8
16 leukemia 9.8
17 thrombosis 9.8
18 meningococcal meningitis 9.8
19 malignant hypertension 9.8
20 pituitary infarct 9.8
21 nephrosclerosis 9.8
22 shigellosis 9.8
23 plasmodium vivax malaria 9.8
24 crescentic glomerulonephritis 9.8
25 eclampsia 9.8
26 cryoglobulinemia 9.8
27 purpura 9.8
28 uremia 9.8
29 ureteral obstruction 9.8
30 mucormycosis 9.8
31 monocytic leukemia 9.8
32 hypopituitarism 9.8
33 meningitis 9.8
34 placental abruption 9.8
35 hellp syndrome 9.7 GPT HADHA

Graphical network of the top 20 diseases related to Kidney Cortex Necrosis:



Diseases related to Kidney Cortex Necrosis

Symptoms & Phenotypes for Kidney Cortex Necrosis

MGI Mouse Phenotypes related to Kidney Cortex Necrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.02 ATRN GFM1 HADHA MMACHC TYR

Drugs & Therapeutics for Kidney Cortex Necrosis

Drugs for Kidney Cortex Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 3 1197-18-8 5526
2 Antifibrinolytic Agents Phase 3
3 Coagulants Phase 3
4 Hemostatics Phase 3
5 Pharmaceutical Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety Study of XP12B in Women With Menorrhagia Completed NCT00113568 Phase 3 Tranexamic acid tablets (XP12B)
2 A Study of CSL112 in Adults With Moderate Renal Impairment and Acute Myocardial Infarction Completed NCT02742103 Phase 2
3 Regional and Long Term Outcomes of Acute Kidney Injury in England From 2000 to 2015 - A National Database Study Completed NCT02675296
4 Predictive Value of PIIINP and Urinary NGAL in Renal Function Recovery Completed NCT02889575

Search NIH Clinical Center for Kidney Cortex Necrosis

Cochrane evidence based reviews: kidney cortex necrosis

Genetic Tests for Kidney Cortex Necrosis

Anatomical Context for Kidney Cortex Necrosis

MalaCards organs/tissues related to Kidney Cortex Necrosis:

41
Kidney, Cortex, Placenta, Pituitary, Smooth Muscle, Monocytes, Liver

Publications for Kidney Cortex Necrosis

Articles related to Kidney Cortex Necrosis:

(show top 50) (show all 193)
# Title Authors Year
1
Bilateral renal cortical necrosis following acute pancreatitis - A rare complication of a common disease. ( 30381522 )
2018
2
Reverse rim sign: acute renal cortical necrosis. ( 29704015 )
2018
3
N-methylamphetamine ("Crystal Meth")-Associated Acute Renal Cortical Necrosis. ( 30450474 )
2018
4
Postpartum renal cortical necrosis. ( 30466570 )
2018
5
Bilateral renal cortical necrosis associated with smoking synthetic cannabinoids. ( 28685136 )
2017
6
Tranexamic Acid-Induced Acute Renal Cortical Necrosis in Post-Endoscopic Papillectomy Bleeding. ( 28793394 )
2017
7
Snakebite Induced Thrombotic Microangiopathy Leading to Renal Cortical Necrosis. ( 28884034 )
2017
8
Acute renal cortical necrosis in pregnancy: Clinical course and changing prognosis. ( 29100716 )
2017
9
Renal cortical necrosis: A life-threatening manifestation of primary antiphospholipid antibody syndrome. ( 27194848 )
2016
10
Renal Cortical Necrosis in Postpartum Hemorrhage: A Case Series. ( 26786299 )
2016
11
Menstrual loss of renal function: a case of mefenamic acid induced renal cortical necrosis. ( 27443568 )
2016
12
Bilateral renal cortical necrosis in a patient undergoing in vitro fertilization. ( 27512312 )
2016
13
Purtscher's retinopathy and renal cortical necrosis: two rare vaso-occlusive complications in a patient with acute pancreatitis: a case report. ( 27846860 )
2016
14
Renal cortical necrosis is a disappearing entity in obstetric acute kidney injury in developing countries: our three decade of experience from India. ( 26133740 )
2015
15
Changing picture of renal cortical necrosis in acute kidney injury in developing country. ( 26558184 )
2015
16
Bisphosphonate-induced bilateral acute renal cortical necrosis. ( 27398112 )
2015
17
Renal cortical necrosis: A rare complication of Plasmodium vivax malaria. ( 25484536 )
2014
18
Bilateral renal cortical necrosis with end-stage renal failure following envenoming by Proatheris superciliaris: a case report. ( 24709757 )
2014
19
Contrast enhanced ultrasound (CEUS) in the diagnosis of post-partum bilateral renal cortical necrosis: a case report and review of the literature. ( 24590397 )
2014
20
Postoperative renal cortical necrosis in a patient with contralateral remnant kidney. ( 25010312 )
2014
21
Postoperative hemolytic uremic syndrome with renal cortical necrosis following laparoscopic hemicolectomy. ( 23560430 )
2013
22
Post-partum bilateral renal cortical necrosis in antiphospholipid syndrome and systemic lupus erythematosus. ( 23640629 )
2013
23
Renal cortical necrosis following a colonoscopy. ( 22913920 )
2013
24
APLA in post-partum renal cortical necrosis another skeleton in the closet. ( 23354213 )
2013
25
Unilateral renal cortical necrosis: report of a case. ( 23498855 )
2013
26
Renal cortical necrosis in a renal transplant recipient. ( 23814432 )
2013
27
Renal cortical necrosis in tropics. ( 23816721 )
2013
28
Renal cortical necrosis secondary to thrombotic microangiopathy in the context of acute promyelocytic leukaemia blast crisis. ( 24241370 )
2013
29
Bilateral renal cortical necrosis following binge drinking. ( 22215004 )
2012
30
Renal cortical necrosis in a live kidney donor. ( 22279344 )
2012
31
Renal cortical necrosis, peripheral gangrene, perinephric and retroperitoneal haematoma in a patient with a viper bite. ( 22316624 )
2012
32
Renal cortical necrosis and acute kidney injury associated with Plasmodium vivax: a neglected human malaria parasite. ( 22669691 )
2012
33
Bilateral Renal Cortical Necrosis with Chronic Renal Failure as a Result of Placenta Percreta in a Twin Pregnancy - A Case Report. ( 25258461 )
2012
34
Bilateral acute renal cortical necrosis in SLE-associated antiphospholipid syndrome. ( 21514023 )
2011
35
Bilateral renal cortical necrosis in meningococcal meningitis. ( 24527235 )
2011
36
Sepsis-induced acute bilateral renal cortical necrosis. ( 22029648 )
2011
37
Renal cortical necrosis at presentation in a patient with systemic lupus erythematosus: an autopsy case report. ( 20169460 )
2010
38
Acute bilateral renal cortical necrosis complicating pyomyoma. ( 20190496 )
2010
39
Vitamin deficiency and renal cortical necrosis. ( 20638557 )
2010
40
Vitamin deficiency and renal cortical necrosis. ( 20638559 )
2010
41
A successful pregnancy in a dialysis patient with renal cortical necrosis. ( 21069918 )
2010
42
Obstetrical associated renal, cortical necrosis: uncommon but not rare! ( 22338423 )
2010
43
Acute renal cortical necrosis due to acquired antiprotein S antibodies. ( 18777044 )
2009
44
Bilateral renal cortical necrosis in acute pancreatitis. ( 20436735 )
2009
45
Renal cortical necrosis complicating laundry detergent ingestion. ( 25949283 )
2009
46
The Case. Generalized petechiae and acute renal failure: bilateral renal cortical necrosis in meningococcemia. ( 18516063 )
2008
47
Decreasing incidence of renal cortical necrosis in patients with acute renal failure in developing countries: a single-centre experience of 22 years from Eastern India. ( 17267539 )
2007
48
Renal cortical necrosis after kidney transplantation associated with the prothrombin 20210A mutation. ( 16357049 )
2006
49
Renal cortical necrosis related to paraneoplastic antiphospholipid syndrome. ( 16731303 )
2006
50
Acute renal cortical necrosis in a series of young men with severe acute pancreatitis. ( 17063988 )
2006

Variations for Kidney Cortex Necrosis

Expression for Kidney Cortex Necrosis

Search GEO for disease gene expression data for Kidney Cortex Necrosis.

Pathways for Kidney Cortex Necrosis

Pathways related to Kidney Cortex Necrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.95 GPT HADHA

GO Terms for Kidney Cortex Necrosis

Biological processes related to Kidney Cortex Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.13 HADHA MMACHC TYR
2 pigmentation GO:0043473 8.62 ATRN TYR

Molecular functions related to Kidney Cortex Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 8.8 HADHA MMACHC TYR

Sources for Kidney Cortex Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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