MCID: KDN001
MIFTS: 31

Kidney Cortex Necrosis

Categories: Nephrological diseases

Aliases & Classifications for Kidney Cortex Necrosis

MalaCards integrated aliases for Kidney Cortex Necrosis:

Name: Kidney Cortex Necrosis 12 44 15 17 70
Renal Cortical Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2973
MeSH 44 D007673
SNOMED-CT 67 444691002
ICD10 32 N17.1
UMLS 70 C0022656

Summaries for Kidney Cortex Necrosis

Disease Ontology : 12 A kidney cortex disease that is characterized by death of the tissue in the outer part of the kidney that results from blockage of the small arteries that supply blood to the cortex and that causes acute kidney injury.

MalaCards based summary : Kidney Cortex Necrosis, also known as renal cortical necrosis, is related to anuria and acute kidney failure. An important gene associated with Kidney Cortex Necrosis is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are Platelet Aggregation Inhibitor Pathway, Pharmacodynamics and Complement and coagulation cascades. Affiliated tissues include kidney, cortex and pituitary, and related phenotype is homeostasis/metabolism.

Related Diseases for Kidney Cortex Necrosis

Diseases related to Kidney Cortex Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 anuria 30.1 F2 ADAMTS13
2 acute kidney failure 29.9 SLC22A12 F2 ADAMTS13
3 hemolytic uremic syndrome, atypical 1 29.8 MMACHC CFI ADAMTS13
4 hellp syndrome 29.8 F2 CFI ADAMTS13
5 nephrosclerosis 29.8 F2 ADAMTS13
6 bilirubin metabolic disorder 29.7 F2 CYP2B6 ADAMTS13
7 thrombotic thrombocytopenic purpura 29.6 CFI ADAMTS13
8 disseminated intravascular coagulation 29.5 PLG F2 ADAMTS13
9 nonbacterial thrombotic endocarditis 29.5 PLG F2 ADAMTS13
10 thrombocytopenia 29.2 PLG F2 CFI ADAMTS13
11 hemolytic anemia 29.2 F2 CFI ADAMTS13
12 hemolytic-uremic syndrome 28.6 PLG MMACHC F2 CFI ADAMTS13
13 shwartzman phenomenon 10.5
14 acute pancreatitis 10.3
15 kidney disease 10.3
16 pancreatitis 10.3
17 acute kidney tubular necrosis 10.2
18 antiphospholipid syndrome 10.2
19 placental abruption 10.2
20 metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 10.2
21 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.2
22 glomerulonephritis 10.2
23 end stage renal disease 10.2
24 hypertensive encephalopathy 10.2 F2 ADAMTS13
25 acquired von willebrand syndrome 10.2 F2 ADAMTS13
26 splenic sequestration 10.2 F2 ADAMTS13
27 immune-complex glomerulonephritis 10.1 H2AC18 CFI
28 primary thrombocytopenia 10.1 F2 ADAMTS13
29 systemic lupus erythematosus 10.1
30 interstitial nephritis 10.1
31 eclampsia 10.1
32 lupus erythematosus 10.1
33 meningococcemia 10.1
34 splenic disease 10.1 H2AC18 F2
35 metal metabolism disorder 10.1 H2AC18 F2
36 complement deficiency 10.1 CFI ADAMTS13
37 von willebrand's disease 10.1 F2 ADAMTS13
38 blood protein disease 10.1 H2AC18 F2
39 malaria 10.0
40 acute promyelocytic leukemia 10.0
41 proteinuria, chronic benign 10.0
42 meningococcal meningitis 10.0
43 hydronephrosis 10.0
44 purpura 10.0
45 waterhouse-friderichsen syndrome 10.0
46 acute cystitis 10.0 H2AC18 F2
47 exanthem 10.0 H2AC18 F2
48 methylmalonic aciduria and homocystinuria, cblc type 10.0 MMACHC ADAMTS13
49 necrotizing fasciitis 10.0 PLG H2AC18
50 anterior spinal artery syndrome 10.0 PLG F2

Graphical network of the top 20 diseases related to Kidney Cortex Necrosis:



Diseases related to Kidney Cortex Necrosis

Symptoms & Phenotypes for Kidney Cortex Necrosis

MGI Mouse Phenotypes related to Kidney Cortex Necrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 ADAMTS13 ATRN CFI F2 IFNGR2 MMACHC

Drugs & Therapeutics for Kidney Cortex Necrosis

Search Clinical Trials , NIH Clinical Center for Kidney Cortex Necrosis

Cochrane evidence based reviews: kidney cortex necrosis

Genetic Tests for Kidney Cortex Necrosis

Anatomical Context for Kidney Cortex Necrosis

MalaCards organs/tissues related to Kidney Cortex Necrosis:

40
Kidney, Cortex, Pituitary, Smooth Muscle, Thyroid, Uterus, Placenta

Publications for Kidney Cortex Necrosis

Articles related to Kidney Cortex Necrosis:

(show top 50) (show all 383)
# Title Authors PMID Year
1
Bilateral acute renal cortical necrosis after a dog bite: case report. 61
33639872 2021
2
A Rare Case of Unilateral Renal Cortical Necrosis. 61
33708801 2021
3
Multiparametric ultrasound findings in acute kidney failure due to rare renal cortical necrosis. 61
33479443 2021
4
Renal ischemic adverse drug events related to tranexamic acid in women of child-bearing age: an analysis of pharmacovigilance data. 61
33341923 2020
5
Protective effect of cordycepin on experimental renal ischemia/reperfusion injury in rats. 61
33348963 2020
6
Bilateral renal cortical necrosis in a child with acute pancreatitis. 61
33565452 2020
7
A Pictorial Review of Postpartum Complications. 61
33095681 2020
8
Post-partum acute kidney injury: sorting placental and non-placental thrombotic microangiopathies using the trajectory of biomarkers. 61
30805631 2020
9
Naproxen Induced Acute Interstitial Nephritis with Renal Cortical Necrosis. 61
33707822 2020
10
Changing epidemiology of acute kidney injury in pregnancy: A journey of four decades from a developing country. 61
31696851 2019
11
Bilateral Renal Cortical Necrosis in a Case of Granulomatosis with Polyangitis. 61
31571748 2019
12
Renal Cortical Necrosis; Five Consecutive Cases within Short Span of Time. 61
31464250 2019
13
Partially Reversible Acute Renal Cortical Necrosis Secondary to Hyperhomocysteinemia - A Case Report and Literature Review. 61
31423065 2019
14
Renal histopathology of prolonged acute kidney injury in HELLP syndrome: a case series and literature review. 61
30989562 2019
15
[Renal cortical necrosis after application of tranexamic acid in peripartal hemorrhage]. 61
31083737 2019
16
Postpartum Renal Cortical Necrosis Is Associated With Atypical Hemolytic Uremic Syndrome in Developing Countries. 61
30899869 2019
17
Acute cortical necrosis in pregnancy still an important cause for end-stage renal disease in developing countries. 61
31031368 2019
18
Ileal Tuberculosis Causing Hypercalcemia and Renal Failure. 61
30814795 2019
19
Postpartum renal cortical necrosis. 61
30466570 2018
20
Reverse rim sign: acute renal cortical necrosis. 61
29704015 2018
21
N-methylamphetamine ("Crystal Meth")-Associated Acute Renal Cortical Necrosis. 61
30450474 2018
22
Bilateral renal cortical necrosis following acute pancreatitis - A rare complication of a common disease. 61
30381522 2018
23
Fulminant group A streptococcal infection without gangrene in the extremities: Analysis of five autopsy cases. 61
29722472 2018
24
Acute renal cortical necrosis in pregnancy: Clinical course and changing prognosis. 61
29100716 2017
25
Atypical hemolytic-uremic syndrome due to complement factor I mutation. 61
29226095 2017
26
Tranexamic Acid-Induced Acute Renal Cortical Necrosis in Post-Endoscopic Papillectomy Bleeding. 61
28793394 2017
27
Diagnosis of cobalamin C deficiency with renal abnormality from onset in a Chinese child by next generation sequencing: A case report. 61
29042959 2017
28
Bilateral renal cortical necrosis associated with smoking synthetic cannabinoids. 61
28685136 2017
29
Clinicopathological spectrum of snake bite-induced acute kidney injury from India. 61
28540205 2017
30
Snakebite Induced Thrombotic Microangiopathy Leading to Renal Cortical Necrosis. 61
28884034 2017
31
Purtscher's retinopathy and renal cortical necrosis: two rare vaso-occlusive complications in a patient with acute pancreatitis: a case report. 61
27846860 2016
32
Menstrual loss of renal function: a case of mefenamic acid induced renal cortical necrosis. 61
27443568 2016
33
Bilateral renal cortical necrosis in a patient undergoing in vitro fertilization. 61
27512312 2016
34
Changing picture of acute kidney injury in pregnancy: Study of 259 cases over a period of 33 years. 61
27512298 2016
35
Renal Cortical Necrosis in Postpartum Hemorrhage: A Case Series. 61
26786299 2016
36
Renal cortical necrosis: A life-threatening manifestation of primary antiphospholipid antibody syndrome. 61
27194848 2016
37
Changing picture of renal cortical necrosis in acute kidney injury in developing country. 61
26558184 2015
38
Renal cortical necrosis is a disappearing entity in obstetric acute kidney injury in developing countries: our three decade of experience from India. 61
26133740 2015
39
Bisphosphonate-induced bilateral acute renal cortical necrosis. 61
27398112 2015
40
Acute kidney injury in pregnancy--a single center experience. 61
26338215 2015
41
Short-term menhaden oil rich diet changes renal lipid profile in acute kidney injury. 61
25948137 2015
42
Renal cortical necrosis: A rare complication of Plasmodium vivax malaria. 61
25484536 2014
43
Hyperparathyroidism complicating pregnancy: a diagnostic challenge? 61
25121380 2014
44
Bilateral renal cortical necrosis with end-stage renal failure following envenoming by Proatheris superciliaris: a case report. 61
24709757 2014
45
Acute kidney injury associated with Plasmodium malariae infection. 61
24906879 2014
46
Contrast enhanced ultrasound (CEUS) in the diagnosis of post-partum bilateral renal cortical necrosis: a case report and review of the literature. 61
24590397 2014
47
Postoperative renal cortical necrosis in a patient with contralateral remnant kidney. 61
25010312 2014
48
Molecular pathology of acute kidney injury in a choline-deficient model and fish oil protective effect. 61
24129499 2014
49
A novel biomarker for acute kidney injury using TaqMan-based unmethylated DNA-specific polymerase chain reaction. 61
24942860 2014
50
Renal cortical necrosis secondary to thrombotic microangiopathy in the context of acute promyelocytic leukaemia blast crisis. 61
24241370 2013

Variations for Kidney Cortex Necrosis

Expression for Kidney Cortex Necrosis

Search GEO for disease gene expression data for Kidney Cortex Necrosis.

Pathways for Kidney Cortex Necrosis

GO Terms for Kidney Cortex Necrosis

Cellular components related to Kidney Cortex Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.1 SLC22A12 PLG H2AC18 F2 CFI ATRN

Biological processes related to Kidney Cortex Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.62 PLG F2 CFI ADAMTS13
2 blood coagulation GO:0007596 9.43 PLG F2 ADAMTS13
3 fibrinolysis GO:0042730 9.16 PLG F2
4 negative regulation of fibrinolysis GO:0051918 8.96 PLG F2
5 hemostasis GO:0007599 8.8 PLG F2 ADAMTS13

Molecular functions related to Kidney Cortex Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.33 PLG F2 CFI
2 peptidase activity GO:0008233 9.26 PLG F2 CFI ADAMTS13
3 serine-type peptidase activity GO:0008236 8.8 PLG F2 CFI

Sources for Kidney Cortex Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....