MCID: KDN001
MIFTS: 34

Kidney Cortex Necrosis

Categories: Nephrological diseases

Aliases & Classifications for Kidney Cortex Necrosis

MalaCards integrated aliases for Kidney Cortex Necrosis:

Name: Kidney Cortex Necrosis 12 45 15 17 74
Renal Cortical Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2973
MeSH 45 D007673
SNOMED-CT 69 45456005
ICD10 34 N17.1
UMLS 74 C0022656

Summaries for Kidney Cortex Necrosis

MalaCards based summary : Kidney Cortex Necrosis, also known as renal cortical necrosis, is related to hemolytic uremic syndrome, atypical 1 and shwartzman phenomenon. An important gene associated with Kidney Cortex Necrosis is TYR (Tyrosinase). The drugs Tranexamic Acid and Coagulants have been mentioned in the context of this disorder. Affiliated tissues include kidney, cortex and placenta, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Wikipedia : 77 Renal cortical necrosis (RCN) is a rare cause of acute kidney failure. The condition is "usually caused... more...

Related Diseases for Kidney Cortex Necrosis

Diseases related to Kidney Cortex Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 hemolytic uremic syndrome, atypical 1 29.3 CFI MMACHC
2 shwartzman phenomenon 10.3
3 pancreatitis 10.2
4 acute pancreatitis 10.2
5 hemolytic-uremic syndrome 10.1
6 antiphospholipid syndrome 10.1
7 systemic lupus erythematosus 10.0
8 lupus erythematosus 10.0
9 malaria 9.9
10 glomerulonephritis 9.9
11 hydronephrosis 9.9
12 anuria 9.9
13 waterhouse-friderichsen syndrome 9.9
14 meningococcemia 9.9
15 end stage renal failure 9.8
16 leukemia 9.8
17 thrombosis 9.8
18 meningococcal meningitis 9.8
19 malignant hypertension 9.8
20 pituitary infarct 9.8
21 nephrosclerosis 9.8
22 shigellosis 9.8
23 plasmodium vivax malaria 9.8
24 crescentic glomerulonephritis 9.8
25 eclampsia 9.8
26 cryoglobulinemia 9.8
27 purpura 9.8
28 uremia 9.8
29 ureteral obstruction 9.8
30 mucormycosis 9.8
31 monocytic leukemia 9.8
32 hypopituitarism 9.8
33 meningitis 9.8
34 placental abruption 9.8
35 acute kidney failure 9.7 SLC22A12 TYR

Graphical network of the top 20 diseases related to Kidney Cortex Necrosis:



Diseases related to Kidney Cortex Necrosis

Symptoms & Phenotypes for Kidney Cortex Necrosis

MGI Mouse Phenotypes related to Kidney Cortex Necrosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.55 ATRN CFI MMACHC SLC22A12 TYR
2 endocrine/exocrine gland MP:0005379 9.43 ATRN SLC22A12 TYR
3 renal/urinary system MP:0005367 9.26 CFI MMACHC SLC22A12 TYR
4 reproductive system MP:0005389 8.92 ATRN MMACHC SLC22A12 TYR

Drugs & Therapeutics for Kidney Cortex Necrosis

Drugs for Kidney Cortex Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 3 1197-18-8 5526
2 Coagulants Phase 3
3 Hemostatics Phase 3
4 Antifibrinolytic Agents Phase 3
5 Pharmaceutical Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety Study of XP12B in Women With Menorrhagia Completed NCT00113568 Phase 3 Tranexamic acid tablets (XP12B)
2 A Study of CSL112 in Adults With Moderate Renal Impairment and Acute Myocardial Infarction Completed NCT02742103 Phase 2
3 Regional and Long Term Outcomes of Acute Kidney Injury in England From 2000 to 2015 - A National Database Study Completed NCT02675296
4 Predictive Value of PIIINP and Urinary NGAL in Renal Function Recovery Completed NCT02889575

Search NIH Clinical Center for Kidney Cortex Necrosis

Cochrane evidence based reviews: kidney cortex necrosis

Genetic Tests for Kidney Cortex Necrosis

Anatomical Context for Kidney Cortex Necrosis

MalaCards organs/tissues related to Kidney Cortex Necrosis:

42
Kidney, Cortex, Placenta, Pituitary, Monocytes, Smooth Muscle, Uterus

Publications for Kidney Cortex Necrosis

Articles related to Kidney Cortex Necrosis:

(show top 50) (show all 194)
# Title Authors Year
1
Postpartum Renal Cortical Necrosis Is Associated With Atypical Hemolytic Uremic Syndrome in Developing Countries. ( 30899869 )
2019
2
Postpartum renal cortical necrosis. ( 30466570 )
2018
3
N-methylamphetamine ("Crystal Meth")-Associated Acute Renal Cortical Necrosis. ( 30450474 )
2018
4
Reverse rim sign: acute renal cortical necrosis. ( 29704015 )
2018
5
Bilateral renal cortical necrosis following acute pancreatitis - A rare complication of a common disease. ( 30381522 )
2018
6
Acute renal cortical necrosis in pregnancy: Clinical course and changing prognosis. ( 29100716 )
2017
7
Snakebite Induced Thrombotic Microangiopathy Leading to Renal Cortical Necrosis. ( 28884034 )
2017
8
Tranexamic Acid-Induced Acute Renal Cortical Necrosis in Post-Endoscopic Papillectomy Bleeding. ( 28793394 )
2017
9
Bilateral renal cortical necrosis associated with smoking synthetic cannabinoids. ( 28685136 )
2017
10
Bilateral renal cortical necrosis in a patient undergoing in vitro fertilization. ( 27512312 )
2016
11
Menstrual loss of renal function: a case of mefenamic acid induced renal cortical necrosis. ( 27443568 )
2016
12
Renal Cortical Necrosis in Postpartum Hemorrhage: A Case Series. ( 26786299 )
2016
13
Purtscher's retinopathy and renal cortical necrosis: two rare vaso-occlusive complications in a patient with acute pancreatitis: a case report. ( 27846860 )
2016
14
Renal cortical necrosis: A life-threatening manifestation of primary antiphospholipid antibody syndrome. ( 27194848 )
2016
15
Bisphosphonate-induced bilateral acute renal cortical necrosis. ( 27398112 )
2015
16
Changing picture of renal cortical necrosis in acute kidney injury in developing country. ( 26558184 )
2015
17
Renal cortical necrosis is a disappearing entity in obstetric acute kidney injury in developing countries: our three decade of experience from India. ( 26133740 )
2015
18
Postoperative renal cortical necrosis in a patient with contralateral remnant kidney. ( 25010312 )
2014
19
Contrast enhanced ultrasound (CEUS) in the diagnosis of post-partum bilateral renal cortical necrosis: a case report and review of the literature. ( 24590397 )
2014
20
Renal cortical necrosis: A rare complication of Plasmodium vivax malaria. ( 25484536 )
2014
21
Bilateral renal cortical necrosis with end-stage renal failure following envenoming by Proatheris superciliaris: a case report. ( 24709757 )
2014
22
Renal cortical necrosis secondary to thrombotic microangiopathy in the context of acute promyelocytic leukaemia blast crisis. ( 24241370 )
2013
23
Renal cortical necrosis in tropics. ( 23816721 )
2013
24
Renal cortical necrosis in a renal transplant recipient. ( 23814432 )
2013
25
Unilateral renal cortical necrosis: report of a case. ( 23498855 )
2013
26
APLA in post-partum renal cortical necrosis another skeleton in the closet. ( 23354213 )
2013
27
Renal cortical necrosis following a colonoscopy. ( 22913920 )
2013
28
Post-partum bilateral renal cortical necrosis in antiphospholipid syndrome and systemic lupus erythematosus. ( 23640629 )
2013
29
Postoperative hemolytic uremic syndrome with renal cortical necrosis following laparoscopic hemicolectomy. ( 23560430 )
2013
30
Bilateral Renal Cortical Necrosis with Chronic Renal Failure as a Result of Placenta Percreta in a Twin Pregnancy - A Case Report. ( 25258461 )
2012
31
Renal cortical necrosis and acute kidney injury associated with Plasmodium vivax: a neglected human malaria parasite. ( 22669691 )
2012
32
Renal cortical necrosis, peripheral gangrene, perinephric and retroperitoneal haematoma in a patient with a viper bite. ( 22316624 )
2012
33
Renal cortical necrosis in a live kidney donor. ( 22279344 )
2012
34
Bilateral renal cortical necrosis following binge drinking. ( 22215004 )
2012
35
Sepsis-induced acute bilateral renal cortical necrosis. ( 22029648 )
2011
36
Bilateral acute renal cortical necrosis in SLE-associated antiphospholipid syndrome. ( 21514023 )
2011
37
Bilateral renal cortical necrosis in meningococcal meningitis. ( 24527235 )
2011
38
Obstetrical associated renal, cortical necrosis: uncommon but not rare! ( 22338423 )
2010
39
A successful pregnancy in a dialysis patient with renal cortical necrosis. ( 21069918 )
2010
40
Vitamin deficiency and renal cortical necrosis. ( 20638559 )
2010
41
Vitamin deficiency and renal cortical necrosis. ( 20638557 )
2010
42
Acute bilateral renal cortical necrosis complicating pyomyoma. ( 20190496 )
2010
43
Renal cortical necrosis at presentation in a patient with systemic lupus erythematosus: an autopsy case report. ( 20169460 )
2010
44
Renal cortical necrosis complicating laundry detergent ingestion. ( 25949283 )
2009
45
Bilateral renal cortical necrosis in acute pancreatitis. ( 20436735 )
2009
46
Acute renal cortical necrosis due to acquired antiprotein S antibodies. ( 18777044 )
2009
47
The Case. Generalized petechiae and acute renal failure: bilateral renal cortical necrosis in meningococcemia. ( 18516063 )
2008
48
Decreasing incidence of renal cortical necrosis in patients with acute renal failure in developing countries: a single-centre experience of 22 years from Eastern India. ( 17267539 )
2007
49
Canine renal cortical necrosis and haemorrhage following ingestion of an Amitraz-formulated insecticide dip. ( 17137059 )
2006
50
Acute renal cortical necrosis in a series of young men with severe acute pancreatitis. ( 17063988 )
2006

Variations for Kidney Cortex Necrosis

Expression for Kidney Cortex Necrosis

Search GEO for disease gene expression data for Kidney Cortex Necrosis.

Pathways for Kidney Cortex Necrosis

GO Terms for Kidney Cortex Necrosis

Biological processes related to Kidney Cortex Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.13 TYR MMACHC CYP2B6
2 pigmentation GO:0043473 8.62 TYR ATRN

Molecular functions related to Kidney Cortex Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.13 CYP2B6 MMACHC TYR
2 monooxygenase activity GO:0004497 8.32 CYP2B6

Sources for Kidney Cortex Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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