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MCID: KDN018
MIFTS: 72

Kidney Disease

Categories: Blood diseases, Bone diseases, Genetic diseases, Nephrological diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Kidney Disease

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MalaCards integrated aliases for Kidney Disease:

Name: Kidney Disease 12 6 15 17
Renal Failure 74 54 39 32
Nephropathy 12 74 29 6
Kidney Diseases 42 43 71
Kidney Failure 42 17 71
Abnormality of the Kidney 29 6
Impaired Renal Function Disease 12
Renal Failure Adverse Event 71
Abnormal Renal Function 71
Kidney Dysfunction 54
Renal Anomaly 54
Renal Disease 54
Nephropathies 15

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Nephrological diseases Blood diseases Bone diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:557
MeSH 43 D007674
NCIt 49 C3149
SNOMED-CT 67 90708001
ICD10 32 N08 N17-N19 N19
UMLS 71 C0022658 C0035078 C0151746 more
Sources

Summaries for Kidney Disease

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MedlinePlus : 42 Healthy kidneys clean your blood by removing excess fluid, minerals, and wastes. They also make hormones that keep your bones strong and your blood healthy. But if the kidneys are damaged, they don't work properly. Harmful wastes can build up in your body. Your blood pressure may rise. Your body may retain excess fluid and not make enough red blood cells. This is called kidney failure. If your kidneys fail, you need treatment to replace the work they normally do. The treatment options are dialysis or a kidney transplant. Each treatment has benefits and drawbacks. No matter which treatment you choose, you'll need to make some changes in your life, including how you eat and plan your activities. But with the help of health care providers, family, and friends, most people with kidney failure can lead full and active lives. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Kidney Disease, also known as renal failure, is related to chronic kidney disease and polycystic kidney disease, and has symptoms including polyuria An important gene associated with Kidney Disease is COL4A5 (Collagen Type IV Alpha 5 Chain), and among its related pathways/superpathways are Organelle biogenesis and maintenance and Amoebiasis. The drugs Pioglitazone and Nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone, and related phenotypes are cardiovascular system and cellular

Disease Ontology : 12 A urinary system disease that is located in the kidney.

Wikipedia : 74 Kidney disease, or renal disease, also known as nephropathy, is damage to or disease of a kidney.... more...

Sources

Related Diseases for Kidney Disease

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Diseases in the Kidney Disease family:

Acute Kidney Failure Renal Infectious Disease
Chronic Kidney Disease Ren-Related Kidney Disease

Diseases related to Kidney Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 3050)
# Related Disease Score Top Affiliating Genes
1 chronic kidney disease 36.0 UMOD UBD PKD2 PKD1 NPHS2 CST3
2 polycystic kidney disease 35.9 TMEM67 PKHD1 PKD2L2 PKD2L1 PKD2 PKD1
3 polycystic kidney disease 1 with or without polycystic liver disease 35.8 UMOD PKHD1 PKD2L1 PKD2 PKD1 IFT88
4 autosomal dominant polycystic kidney disease 35.8 PKHD1 PKD2L2 PKD2L1 PKD2 PKD1 CST3
5 polycystic kidney disease 2 with or without polycystic liver disease 35.5 TMEM67 PKHD1 PKD2L2 PKD2L1 PKD2 PKD1
6 polycystic kidney disease 4 with or without polycystic liver disease 35.5 UMOD TMEM67 PKHD1 PKD2 PKD1 IFT88
7 cystic kidney disease 35.5 UMOD TMEM67 PKHD1 PKD2L2 PKD2L1 PKD2
8 polycystic kidney disease 4 35.0 PKHD1 ALB
9 end stage renal disease 34.7 UMOD PKD2 PKD1 NPHS2 CST3 COL4A5
10 nephronophthisis 34.6 UMOD TMEM67 PKHD1 PKD2 PKD1 IFT88
11 alport syndrome 33.8 PKD1 NPHS2 COL4A5 COL4A4 COL4A3 ALB
12 glomerulonephritis 33.7 NPHS2 COL4A5 COL4A4 COL4A3 ALB ACE
13 polycystic liver disease 33.5 TMEM67 PKHD1 PKD2L1 PKD2 PKD1 ALB
14 alport syndrome 1, x-linked 33.4 COL4A5 COL4A4
15 caroli disease 33.4 PKHD1 PKD2 PKD1
16 focal segmental glomerulosclerosis 33.4 NPHS2 COL4A5 COL4A4 COL4A3 ALB ACE
17 autosomal recessive alport syndrome 33.4 NPHS2 COL4A5 COL4A4 COL4A3
18 senior-loken syndrome 1 33.4 TMEM67 IFT88 CEP290
19 polycystic liver disease 1 with or without kidney cysts 33.3 UMOD PKHD1 PKD2 PKD1
20 acute cystitis 33.3 UMOD CST3 ALB ACE
21 iga glomerulonephritis 33.2 NPHS2 ALB ACE
22 autosomal dominant alport syndrome 33.2 COL4A5 COL4A4 COL4A3
23 nail-patella syndrome 33.2 NPHS2 COL4A4 COL4A3
24 congenital hepatic fibrosis 33.2 TMEM67 PKHD1 PKD1
25 potter's syndrome 33.1 PKHD1 ACE
26 membranous nephropathy 33.1 NPHS2 ALB ACE
27 joubert syndrome 1 33.1 TMEM67 PKHD1 PKD2 PKD1 IFT88 CEP290
28 goodpasture syndrome 33.1 COL4A5 COL4A4 COL4A3 ALB
29 anuria 33.0 CST3 ALB ACE
30 familial nephrotic syndrome 33.0 NPHS2 COL4A5 COL4A4
31 orofaciodigital syndrome 33.0 TMEM67 IFT88 CEP290
32 alport syndrome 2, autosomal recessive 32.8 COL4A4 COL4A3
33 alport syndrome 3, autosomal dominant 32.7 COL4A4 COL4A3
34 kidney papillary necrosis 32.6 ALB ACE
35 impotence 32.6 MIR141 ALB ACE
36 multicystic dysplastic kidney 32.4 PKD2 PKD1
37 meckel syndrome, type 1 32.3 TMEM67 PKHD1 PKD2 PKD1 IFT88 CEP290
38 glomerular disease 32.1 NPHS2 ALB ACE
39 hypertension, essential 32.1 UMOD PKD2 PKD1 NPHS2 CST3 COL4A5
40 acute kidney failure 32.1 UMOD CST3 ALB
41 pyelonephritis 32.1 UMOD ALB ACE
42 joubert syndrome 6 32.0 TMEM67 CEP290
43 interstitial nephritis 32.0 UMOD ALB ACE
44 meckel syndrome, type 3 31.9 TMEM67 IFT88 CEP290
45 hypertensive nephropathy 31.9 CST3 ALB ACE
46 urinary tract obstruction 31.8 UMOD CST3 ALB ACE
47 portal hypertension 31.8 PKHD1 ALB ACE
48 acute kidney tubular necrosis 31.8 UMOD CST3 ALB ACE
49 renal dysplasia, cystic 31.7 PKD1 CEP290
50 vesicoureteral reflux 1 31.7 UMOD CST3 ALB ACE

Comorbidity relations with Kidney Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 51)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Alzheimer Disease Aortic Valve Disease 1
Bladder Neck Obstruction Bronchitis
Bronchopneumonia Cardiac Arrest
Cardiogenic Shock Decubitus Ulcer
Deficiency Anemia Diabetic Polyneuropathy
Encephalopathy Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Gout
Heart Disease Hydronephrosis
Hypertension, Essential Hypoglycemia
Hypoglycemic Coma Hypothyroidism
Intermediate Coronary Syndrome Intestinal Obstruction
Iron Deficiency Anemia Malignant Essential Hypertension
Microvascular Complications of Diabetes 1 Mitral Valve Disease
Nephrosclerosis Paralytic Ileus
Peripheral Vascular Disease Polycystic Kidney Disease
Prostate Cancer Prostatic Hypertrophy
Protein-Energy Malnutrition Pulmonary Hypertension, Primary, 1
Pyelonephritis Renal Artery Atheroma
Renal Artery Disease Respiratory Failure
Schizophreniform Disorder Sinoatrial Node Disease
Swallowing Disorders Third-Degree Atrioventricular Block
Transient Cerebral Ischemia Tricuspid Valve Disease

Graphical network of the top 20 diseases related to Kidney Disease:



Diseases related to Kidney Disease
Sources

Symptoms & Phenotypes for Kidney Disease

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UMLS symptoms related to Kidney Disease:


polyuria

MGI Mouse Phenotypes related to Kidney Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 ACE ALB CEP290 COL4A3 COL4A5 CST3
2 cellular MP:0005384 10.14 ALB CEP290 COL4A3 CST3 IFT88 PKD1
3 homeostasis/metabolism MP:0005376 10.13 ACE ALB CEP290 COL4A3 COL4A4 COL4A5
4 immune system MP:0005387 10 ACE ALB CEP290 COL4A3 COL4A4 COL4A5
5 digestive/alimentary MP:0005381 9.91 ALB COL4A4 IFT88 PKD1 PKD2 PKHD1
6 mortality/aging MP:0010768 9.77 ACE ALB CEP290 COL4A3 COL4A4 COL4A5
7 liver/biliary system MP:0005370 9.76 ACE ALB CEP290 IFT88 PKD1 PKD2
8 renal/urinary system MP:0005367 9.44 ACE ALB CEP290 COL4A3 COL4A4 COL4A5
Sources

Drugs & Therapeutics for Kidney Disease

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Drugs for Kidney Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1216)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
2
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
3
Zaleplon Approved, Illicit, Investigational Phase 4 151319-34-5 5719
4
Moxonidine Approved, Investigational Phase 4 75438-57-2 4810
5
Pancrelipase Approved, Investigational Phase 4 53608-75-6
6
Digoxin Approved Phase 4 20830-75-5 30322 2724385
7
Capsaicin Approved Phase 4 404-86-4 1548943
8
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
9
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
10
Atenolol Approved Phase 4 29122-68-7 2249
11
Gliclazide Approved Phase 4 21187-98-4 3475
12
Scopolamine Approved, Investigational Phase 4 6533-68-2, 51-34-3 5184
13
Travoprost Approved Phase 4 157283-68-6 5282226
14
Latanoprost Approved, Investigational Phase 4 130209-82-4 5311221 5282380
15
Dorzolamide Approved Phase 4 120279-96-1 5284549 3154
16
Brinzolamide Approved Phase 4 138890-62-7 68844
17
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
18
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
19
Ticlopidine Approved Phase 4 55142-85-3 5472
20
Glyburide Approved Phase 4 10238-21-8 3488
21
Indapamide Approved Phase 4 26807-65-8 3702
22
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
23
Colchicine Approved Phase 4 64-86-8 2833 6167
24
Sevelamer Approved Phase 4 52757-95-6
25
Nisoldipine Approved Phase 4 63675-72-9 4499
26
Cinacalcet Approved Phase 4 226256-56-0 156419
27
Telavancin Approved Phase 4 372151-71-8
28
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
29
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
30
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
31
Glucagon Approved Phase 4 16941-32-5
32
Liraglutide Approved Phase 4 204656-20-2 44147092
33
Ticagrelor Approved Phase 4 274693-27-5 9871419
34
Rifaximin Approved, Investigational Phase 4 80621-81-4 6436173 46783403
35
Insulin glulisine Approved Phase 4 207748-29-6
36
Probucol Approved, Investigational Phase 4 23288-49-5 4912
37
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
38
Zidovudine Approved Phase 4 30516-87-1 35370
39
Donepezil Approved Phase 4 120014-06-4 3152
40
Regadenoson Approved, Investigational Phase 4 313348-27-5 219024
41
Terazosin Approved Phase 4 63590-64-7 5401
42
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
43
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
44
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
45
Rilonacept Approved, Investigational Phase 4 501081-76-1 104924
46
Fosinopril Approved Phase 4 98048-97-6 55891
47
Epoprostenol Approved Phase 4 35121-78-9, 61849-14-7 5282411 5280427
48
Deflazacort Approved, Investigational Phase 4 14484-47-0
49
Calcium acetate Approved, Investigational Phase 4 62-54-4
50
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715

Interventional clinical trials:

(show top 50) (show all 8198)
# Name Status NCT ID Phase Drugs
1 Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure Unknown status NCT00716001 Phase 4 N-acetylcysteine
2 Study on the Effect of Hyperuricaemia on Chronic Renal Disease and Intervention Unknown status NCT03425708 Phase 4 20mg Febuxostat;40mg Febuxostat
3 Evaluation of Nail Fold Microcirculation and Interventional Therapy in Patients With Chronic Renal Failure Unknown status NCT03682952 Phase 4 Alprostadil Injection;Beraprost sodium tablets
4 The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients Unknown status NCT00247507 Phase 4 acetylcysteine
5 A Prospective Randomized, Double-Blind Parallel Group Trial To Assess The Efficacy And Safety Of Intravenous Dextrose 5% Solution Compare With Normal Saline (Standard Care) In Rinsing During Haemodialysis In Subjects With End Stage Renal Failure (ESRF) With Respect To Systolic Blood Pressure Control Over 3 Months Period. Unknown status NCT02590081 Phase 4 Dextrose 5%;normal saline
6 Effect of Sarpogrelate On the Nephropathy in Type 2 Diabetes Unknown status NCT01869881 Phase 4 Anplag(Sarpogrelate);Placebo
7 Phase 4 Study of Alprostadil Prevent Contrast Induced Nephropathy in Patients Receiving a Cardiac Catheterization Unknown status NCT01722513 Phase 4 Alprostadil ﹠control
8 Clinical Trial Technology Development for the Validation of Surrogate Prognostic Markers in Patients With Diabetic Nephropathy Unknown status NCT01673204 Phase 4 Calcitriol;Placebo
9 Phase 4 Study of Medical Therapy Versus Medical Therapy Plus Renal Artery Stenting in Preventing the Progression of Renal Failure in Atherosclerotic Renovascular Disease Unknown status NCT01023373 Phase 4 Medical treatment
10 Effect of Aldosterone Antagonism in the Reduction of Albuminuria and Diastolic Disfunction of Patients With Diabetic Nephropathy. Unknown status NCT00870402 Phase 4 Spironolactone;Placebo
11 Sympathetic Nervous System Inhibition for the Treatment of Diabetic Nephropathy Unknown status NCT01094769 Phase 4 Moxonidine;Placebo
12 A comParison on Platelet Resistance With Ticagrelor or Standard-Dose Clopidogrel Study Among SeVerE Chronic Kidney Disease/ End-Stage-Renal-Disease Patients With Recent Acute Coronary Syndrome. Unknown status NCT02459288 Phase 4 Clopidogrel first;Ticagrelor first
13 Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease: a Randomized Clinical Trial Unknown status NCT01155128 Phase 4
14 Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease Unknown status NCT00852787 Phase 4 Digoxin immune fab;Placebo
15 Renoprotection by Combining Pentoxifylline and Angiotensin Blockade in Chronic Kidney Disease Unknown status NCT01377285 Phase 4 ARB;Pentoxifylline;Placebo (for Pentoxifylline)
16 NAC in Preventing CIN in CRF Patients Who Need Enhanced CT Scan in ED Unknown status NCT00501475 Phase 4 NAC Bicarbonate
17 Phase 4 Study of Mechanisms of Low Protein Diet Supplemented With Ketoanalogs on Reducing Proteinuria and Maintaining Nutritional Status in Type 2 Diabetic Nephropathy Unknown status NCT01300273 Phase 4
18 The Metabolic and Anti-Inflammatory Effects of Combined Ezetimibe and Simvastin Therapy, as Compared to Simvastatin Alone, in Patients With Chronic Proteinuric Nephropathy Unknown status NCT00861731 Phase 4 simvastatin;EZE/simvastatin;EZE/simvastatin
19 Safety and Efficacy of Shenyankangfu Tablets for Chronic Kidney Disease Unknown status NCT02885857 Phase 4 Shenyan Kangfu Tablet
20 The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease Unknown status NCT01157260 Phase 4 Kremezin
21 Open Randomized Phase IV Study on Intravenous Iron in Anemic Patients With Chronic Kidney Disease Unknown status NCT00204256 Phase 4 Iron sucrose
22 Phase 4 Study of Sarpogrelate That Prevent Contrast-induced Nephropathy Unknown status NCT01165567 Phase 4 sarpogrelate
23 Preventive Strategies of REnal Insufficiency in Patients With Diabetes Undergoing InterVENTion or Arteriography(PREVENT Trial) Unknown status NCT00950079 Phase 4 Sodium bicarbonate;saline
24 Effect of Intravenous and Oral Therapy With Sulodexide on Albuminuria in Type 2 Diabetic Patients Unknown status NCT01316068 Phase 4 intravenous use of sulodexide followed by oral use;use of sulodexide orally only
25 Preventing Contrast Induced Nephropathy After Transcatheter Aortic Valve Replacement Unknown status NCT03121053 Phase 4 sodium bicarbonate;hypotone saline
26 Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy: a Multicentre, Double-blind, Double-dummy, Randomized Controlled Trial Unknown status NCT02231125 Phase 4 Losartan;Abelmoschus manihot
27 Phase IV, Effect of Rennin-Angiotensin System Blockers on Glomerular Filtration Rate in Patients With Hypertension, Type 2 Diabetes With Normoalbuminuria--- A Randomized Controlled Trial Unknown status NCT01500590 Phase 4 Renin-angiotensin system blockers;non-renin angiotensin system blockers
28 Pulse Wave Velocity, Pulse Wave Morphology and Blocking of the Reninangiotensin System in Patients With Chronic Kidney Disease: An Interventional and Methodological Study Unknown status NCT00235287 Phase 4 Candesartan and enalapril;candesartan and enalapril;candesartan and enalapril;candesartan and enalapril
29 Comparison of Efficacy and Safety Between Benidipine and Hydrochlorothiazide in Fosinopril Treated Chronic Kidney Disease Patients With Hypertension: a Randomized Controlled Trial Unknown status NCT02646397 Phase 4 Fosinopril;Benidipine;Hydrochlorothiazide
30 Preventive Effect of the PRetreatment With pItavastatiN on Contrast-Induced Nephropathy in Patients With RenaL Dysfunction UndErgoing Coronary Angiography/Intervention (PRINCIPLE-II Study) Unknown status NCT01871792 Phase 4 Pitavastatin;Placebo
31 The Role of Qutenza (Topical Capsaicin 8%) in Treating Neuropathic Pain From Critical Ischaemia in Patients With End-stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
32 Simvastatin Effect on Endothelium Dependent Venodilation in Chronic Renal Failure Patients Treated by Peritoneal Dialysis Unknown status NCT00291863 Phase 4 Simvastatin
33 Calcineurin Inhibitor Minimisation in Renal Transplant Recipients With Stable Allograft Function: A Prospective Randomised Controlled Trial Unknown status NCT00541814 Phase 4 Cyclosporine
34 Providing Intravenous Paricalcitol Treatment to the Sick and Poor Chronic Hemodialysis Patients With Severe Secondary Hyperparathyroidism Resistant to Existing Vitamin D Analogs Unknown status NCT03023748 Phase 4 Intravenous Paricalcitol
35 A Randomized Prospective Trial of N-acetyl Cystein in Patients With Peritoneal Dialysis Unknown status NCT01111422 Phase 4 N-acetylcysteine
36 Effect of Ursodeoxycholic Acid on Peritoneal Function in Patients on Peritoneal Dialysis Unknown status NCT02338635 Phase 4 Ursodeoxycholic Acid
37 A Prospective, Randomized, Two Period, With an Intermediate Wash Out Period, Cross-over Study to Compare the Effects of Either Combined Therapy With Ramipril and Clopidogrel or Ramipril Monotherapy on Oxidative Stress, Vascular Inflammation and Endothelial Dysfunction in Patients With Type 2 Diabetes and Diabetic Nephropathy Unknown status NCT01743014 Phase 4 Ramipril;Clopidogrel
38 Comparison Between ARB and ARB Plus CCB on Incidence of Renal and Cardiovascular Events in Hypertensive ADPKD Patients Unknown status NCT00541853 Phase 4 Candesartan;Candesartan and Cilnidipine;Candesartan plus non-CCB agents
39 N-Acetylcysteine to Prevent Contrast-Induced Nephropathy in Acute Coronary Syndromes Unknown status NCT00939913 Phase 4 intravenous NAC;Placebo
40 The Immunogenicity and Safety of the Seasonal Influenza Vaccine, Formulation 2013-2014, in Chronic Kidney Disease Patients Not on Dialysis Unknown status NCT02105519 Phase 4
41 The Effects of Thiazolidinedione on the Diabetic Retinopathy and Nephropathy Unknown status NCT01175486 Phase 4 Actos (Pioglitazone);Acarbose
42 the Effect of Calcium Dobesilate on Non Dialysis Patients With Chronic Renal Failure Unknown status NCT03427944 Phase 4 Calcium Dobesilate group;Conventional Treatment group
43 A Prospective Randomized, Controlled, Open-labeled Trial of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy Unknown status NCT01758120 Phase 4 prednisone plus cyclophosphamide;Prednisone alone
44 Hydroxychloroquine Sulfate Alleviates Persistent Proteinuria in IgA Nephropathy:a Single Center Prospective Randomized Controlled Study Unknown status NCT02765594 Phase 4 Hydroxychloroquine Sulfate;Valsartan
45 Interstitial Fibrosis in Protocol Biopsies of Renal Allografts: A Prospective, Randomised Trial of Sirolimus Versus Cyclosporine.(Fibrasic) Unknown status NCT00493194 Phase 4 sirolimus;cyclosporine;daclizumab
46 A Pilot Study to Treat Patients With Chronic HCV Genotype 1 and ESRD Receiving Hemodialysis and Naïve to Prior HCV Therapy With Peginterferon Alfa-2b, the Maximally Tolerated Ribavirin Dose and Boceprevir Unknown status NCT01731301 Phase 4 Ribavirin;Peginterferon;Boceprevir
47 Renal Toxicity of Iodixanol and Iopromide in Patients With Renal Dysfunction—a Multicentre, Single Blind, Randomized Controlled, Prospective Trial Unknown status NCT01580046 Phase 4 iodixanol;iopromide
48 Safety of Add on Aliskiren to ACEI and ARB Treatment in Type 2 Diabetes With Nephropathy Unknown status NCT00949351 Phase 4 Aliskiren 300mg/d
49 Efficacy and Safety of Abelmoschus Manihot for Chronic Kidney Disease：a Multicentre Open Study Unknown status NCT02231138 Phase 4 Abelmoschus manihot (AM)
50 Effect of Valsartan vs Perindopril on HOMA-IR Index in Patients With Chronic Kidney Disease Unknown status NCT02299310 Phase 4 Valsartan;Perindopril

Search NIH Clinical Center for Kidney Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albumin Human, USP
ALBUMIN,HUMAN INJ
Dopamine
Dopamine Hydrochloride

Cochrane evidence based reviews: kidney diseases

Sources

Genetic Tests for Kidney Disease

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Genetic tests related to Kidney Disease:

# Genetic test Affiliating Genes
1 Nephropathy 29
2 Abnormality of the Kidney 29
Sources

Anatomical Context for Kidney Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Kidney Disease:

19
Kidney

MalaCards organs/tissues related to Kidney Disease:

40
Kidney, Heart, Bone, Liver, Endothelial, Testes, Neutrophil
Sources

Publications for Kidney Disease

About this section

Articles related to Kidney Disease:

(show top 50) (show all 62487)
# Title Authors PMID Year
1
Clinical trial for conventional medicine integrated with traditional Chinese medicine (TCM) in the treatment of patients with chronic kidney disease. 42 61
32481298 2020
2
Effect of statins on cardiovascular complications in chronic kidney disease patients: A network meta-analysis. 61 42
32481375 2020
3
Evidence for Use or Disuse of Renin-Angiotensin System Modulators in Patients Having COVID-19 With an Underlying Cardiorenal Disorder. 42
32351121 2020
4
Is the kidney a target of SARS-CoV-2? 42
32412303 2020
5
Cardiovascular Consequences of Acute Kidney Injury. 42
32492305 2020
6
The use of different dialysis membranes in therapy of patients with multiple myeloma. 42
32544311 2019
7
miR-200a Prevents renal fibrogenesis through repression of TGF-β2 expression. 46
20952520 2011
8
Tumor necrosis factor (TNF-alpha) and C-reactive protein (CRP) are positively associated with the risk of chronic kidney disease in patients with type 2 diabetes. 54 61
20499416 2010
9
Effect of paricalcitol and cinacalcet on serum phosphate, FGF-23, and bone in rats with chronic kidney disease. 54 61
20200094 2010
10
Sulodexide ameliorates early but not late kidney disease in models of radiation nephropathy and diabetic nephropathy. 61 54
20061322 2010
11
Evidence for a role of uromodulin in chronic kidney disease progression. 54 61
20075439 2010
12
An aid to the diagnosis of genetic disorders underlying adult-onset renal failure: a literature review. 54 61
20497759 2010
13
Increment and impairment of adiponectin in renal failure. 61 54
20035033 2010
14
An integrative view on the role of TGF-beta in the progressive tubular deletion associated with chronic kidney disease. 61 54
20336053 2010
15
Performance evaluation of a particle-enhanced turbidimetric cystatin C assay using the Abbott Aeroset analyser and assessment of cystatin C-based equations for estimating glomerular filtration rate in chronic kidney disease. 61 54
20037185 2010
16
Serum creatinine, cystatin C, and beta-trace protein in diagnostic staging and predicting progression of primary nondiabetic chronic kidney disease. 54 61
20224047 2010
17
Is collapsing C1q nephropathy another MYH9-associated kidney disease? A case report. 61 54
20116156 2010
18
Circulating levels of osteopontin are closely related to glomerular filtration rate and cardiovascular risk markers in patients with chronic kidney disease. 61 54
20486990 2010
19
The circulating inactive form of matrix gla protein is a surrogate marker for vascular calcification in chronic kidney disease: a preliminary report. 54 61
20133489 2010
20
Is Fibroblast Growth Factor-23 a novel marker for phosphate burden in chronic kidney disease with prognostic implications? 54 61
20503017 2010
21
Pentoxifylline improves haemoglobin and interleukin-6 levels in chronic kidney disease. 54 61
20470305 2010
22
Predicting potential survival benefit of renal transplantation in patients with chronic kidney disease. 61 54
20351122 2010
23
The influence of glomerular filtration rate and age on fibroblast growth factor 23 serum levels in pediatric chronic kidney disease. 54 61
20157196 2010
24
Terlipressin therapy for renal failure in cirrhosis. 61 54
19952764 2010
25
Molecular diagnostics for autosomal dominant polycystic kidney disease. 61 54
20177400 2010
26
Aldose reductase inhibitors and diabetic kidney disease. 61 54
20336588 2010
27
Diagnostic accuracy of various glomerular filtration rates estimating equations in patients with chronic kidney disease and diabetes. 54 61
20368098 2010
28
Does the downregulation of the FGF23 signaling pathway in hyperplastic parathyroid glands contribute to refractory secondary hyperparathyroidism in CKD patients? 61 54
20150940 2010
29
Visfatin is increased in chronic kidney disease patients with poor appetite and correlates negatively with fasting serum amino acids and triglyceride levels. 54 61
19948877 2010
30
Antagonists of bone morphogenetic proteins in kidney disease. 54 61
20178045 2010
31
HMG CoA reductase inhibition and endothelial function in children with chronic kidney disease (CKD)--a pilot study. 61 54
20050832 2010
32
Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease. 54 61
20016471 2010
33
Erythropoietin response to anemia and its association with autonomic neuropathy in type 2 diabetic patients without advanced renal failure. 54 61
19303331 2010
34
Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK. 54 61
20150538 2010
35
Control of secondary hyperparathyroidism by vitamin D receptor agonists in chronic kidney disease. 61 54
20133492 2010
36
Alterations of retinol-binding protein 4 species in patients with different stages of chronic kidney disease and their relation to lipid parameters. 61 54
20097162 2010
37
Genetic variation at selected SNPs in the leptin gene and association of alleles with markers of kidney disease in a Xhosa population of South Africa. 61 54
20140086 2010
38
A prospective study of fibroblast growth factor-23 in children with chronic kidney disease. 54 61
19929273 2010
39
FGF23-parathyroid interaction: implications in chronic kidney disease. 54 61
20010546 2010
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PKHD1 sequence variations in 78 children and adults with autosomal recessive polycystic kidney disease and congenital hepatic fibrosis. 54 61
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The role of vitamin D receptor activation in chronic kidney disease. 61 54
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Calcium-sensing receptor as a potential modulator of vascular calcification in chronic kidney disease. 54 61
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Combined effects of ghrelin and higher food intake enhance skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rats with chronic kidney disease. 54 61
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Effect of pentoxifylline on proteinuria, markers of tubular injury and oxidative stress in non-diabetic patients with chronic kidney disease - placebo controlled, randomized, cross-over study. 54 61
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Is cystatin C a useful marker in the detection of diabetic kidney disease? 61 54
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CRP polymorphisms and progression of chronic kidney disease in African Americans. 61 54
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Plasma adiponectin levels in chronic kidney disease patients: relation with molecular inflammatory profile and metabolic status. 54 61
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Estimating glomerular filtration rate using the new CKD-EPI equation and other equations in patients with autosomal dominant polycystic kidney disease. 61 54
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Influence of chronic renal failure on acid secretion in isolated gastric mucosal cells from human biopsies. 54 61
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Elevated brain natriuretic peptide is associated with abnormal heart geometry in children with chronic kidney disease. 54 61
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Sources

Variations for Kidney Disease

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ClinVar genetic disease variations for Kidney Disease:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 COL4A5 NM_033380.2(COL4A5):c.1424-2_1430delAGGTGACAAdeletion Pathogenic 523544 rs1556411578 X:107838737-107838745 X:108595507-108595515
2 CEP290 NM_025114.4(CEP290):c.5493del (p.Ala1832fs)deletion Pathogenic 56739 rs386834158 12:88471567-88471567 12:88077790-88077790
3 CEP290 NM_025114.4(CEP290):c.3104-2A>GSNV Pathogenic 374210 rs773386777 12:88487754-88487754 12:88093977-88093977
4 TMEM67 NM_153704.6(TMEM67):c.1843T>C (p.Cys615Arg)SNV Pathogenic/Likely pathogenic 1383 rs201893408 8:94808198-94808198 8:93795970-93795970
5 TMEM67 NM_153704.6(TMEM67):c.1321C>T (p.Arg441Cys)SNV Pathogenic/Likely pathogenic 217725 rs752362727 8:94798483-94798483 8:93786255-93786255
6 PKD1 NM_001009944.3(PKD1):c.3785A>G (p.His1262Arg)SNV Conflicting interpretations of pathogenicity 374206 rs1057518976 16:2161383-2161383 16:2111382-2111382
7 PAX9 , SLC25A21 deletion Uncertain significance 635872 14:37145358-37162210
8 CPT2 NM_000098.3(CPT2):c.1766C>T (p.Thr589Met)SNV Uncertain significance 804352 rs756414686 1:53679056-53679056 1:53213384-53213384

Copy number variations for Kidney Disease from CNVD:

7 (show all 21)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 22040 1 16450000 16950000 Duplication renal disease
2 37196 1 8700000 16000000 Deletion renal disease
3 76925 13 38159172 38359267 Copy number FREM2 renal disease
4 95843 15 81011700 83540700 Deletion renal disease
5 97939 16 14780000 16770000 Deletion renal disease
6 110304 17 31836750 33582750 Microdeletion BC1D3 renal disease
7 110305 17 31836750 33582750 Microdeletion CCL3L1 renal disease
8 110306 17 31836750 33582750 Microdeletion CCL4L1 renal disease
9 110307 17 31836750 33582750 Microdeletion TCF2 renal disease
10 110539 17 33120546 33179209 Copy number HNF1B renal disease
11 110540 17 33120546 33179209 Copy number TCF2 renal disease
12 110544 17 33120546 33179209 Deletion TCF2 renal disease
13 115163 17 55061600 55218400 Duplication renal disease
14 127179 19 28500000 63811651 Microdeletion renal disease
15 127247 19 30200000 37100000 Deletion renal disease
16 128207 19 40300000 43000000 Deletion renal disease
17 160230 22 11800000 24300000 Deletion renal disease
18 189838 4 79197747 79684447 Copy number FRAS1 renal disease
19 191442 5 1 12100000 Duplication renal disease
20 222025 7 148600000 158550000 Deletion renal disease
21 264973 X 71600000 71800000 Duplication renal disease
Sources

Expression for Kidney Disease

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Search GEO for disease gene expression data for Kidney Disease.
Sources

Pathways for Kidney Disease

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Pathways related to Kidney Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Organelle biogenesis and maintenance 65
Show member pathways
 12.49 TMEM67 PKD2 PKD1 IFT88 CEP290
2
Amoebiasis 36
11.64 COL4A5 COL4A4 COL4A3
3
AGE-RAGE signaling pathway in diabetic complications 36
11.61 COL4A5 COL4A4 COL4A3
4
Small cell lung cancer 36
11.54 COL4A5 COL4A4 COL4A3
5
Cell adhesion_ECM remodeling 22
11.28 COL4A5 COL4A4 COL4A3
6
Cell adhesion_Plasmin signaling 22
11.12 COL4A5 COL4A4 COL4A3
7
Cell adhesion_Endothelial cell contacts by non-junctional mechanisms 22
10.93 COL4A5 COL4A4 COL4A3
8
Primary Focal Segmental Glomerulosclerosis FSGS 1
10.79 NPHS2 COL4A5 COL4A4 COL4A3
9
NCAM1 interactions 65
10.7 COL4A5 COL4A4 COL4A3
Sources

GO Terms for Kidney Disease

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Cellular components related to Kidney Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.11 UMOD MIR141 CST3 COL4A5 COL4A4 COL4A3
2 endoplasmic reticulum GO:0005783 10.1 TMEM67 PKD2L1 PKD2 PKD1 NPHS2 CST3
3 cell projection GO:0042995 9.91 UMOD TMEM67 PKHD1 PKD2L1 PKD2 PKD1
4 endoplasmic reticulum lumen GO:0005788 9.85 CST3 COL4A5 COL4A4 COL4A3 ALB
5 ciliary basal body GO:0036064 9.78 PKHD1 PKD2 IFT88 CEP290
6 collagen trimer GO:0005581 9.71 COL4A5 COL4A4 COL4A3
7 basement membrane GO:0005604 9.67 CST3 COL4A5 COL4A4 COL4A3
8 non-motile cilium GO:0097730 9.61 PKD2L1 PKD2 IFT88
9 MKS complex GO:0036038 9.52 TMEM67 CEP290
10 cation channel complex GO:0034703 9.5 PKD2L1 PKD2 PKD1
11 polycystin complex GO:0002133 9.4 PKD2 PKD1
12 ciliary membrane GO:0060170 9.35 UMOD TMEM67 PKD2L1 PKD2 PKD1
13 collagen type IV trimer GO:0005587 9.33 COL4A5 COL4A4 COL4A3
14 cilium GO:0005929 9.23 UMOD TMEM67 PKHD1 PKD2L1 PKD2 PKD1

Biological processes related to Kidney Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cilium assembly GO:0060271 9.76 TMEM67 PKHD1 IFT88 CEP290
2 calcium ion transmembrane transport GO:0070588 9.67 PKD2L2 PKD2L1 PKD2 PKD1
3 kidney development GO:0001822 9.55 PKHD1 PKD2 PKD1 IFT88 ACE
4 protein heterotetramerization GO:0051290 9.54 PKD2 PKD1
5 placenta blood vessel development GO:0060674 9.52 PKD2 PKD1
6 cytoplasmic sequestering of transcription factor GO:0042994 9.51 PKD2 PKD1
7 glomerular basement membrane development GO:0032836 9.49 COL4A4 COL4A3
8 inorganic cation transmembrane transport GO:0098662 9.48 PKD2L1 PKD2
9 mesonephric tubule development GO:0072164 9.43 PKD2 PKD1
10 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.43 COL4A5 COL4A4 COL4A3
11 mesonephric duct development GO:0072177 9.4 PKD2 PKD1
12 cell-cell signaling by wnt GO:0198738 9.32 PKD2 PKD1
13 metanephric ascending thin limb development GO:0072218 9.13 UMOD PKD2 PKD1
14 detection of mechanical stimulus GO:0050982 8.92 PKD2L2 PKD2L1 PKD2 PKD1

Molecular functions related to Kidney Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.33 COL4A5 COL4A4 COL4A3
2 muscle alpha-actinin binding GO:0051371 9.32 PKD2L1 PKD2
3 alpha-actinin binding GO:0051393 9.26 PKD2L1 PKD2
4 extracellular matrix structural constituent GO:0005201 9.26 UMOD COL4A5 COL4A4 COL4A3
5 calcium channel activity GO:0005262 8.92 PKD2L2 PKD2L1 PKD2 PKD1
Sources

Sources for Kidney Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49