MCID: KDN013
MIFTS: 32

Kidney Hypertrophy

Categories: Nephrological diseases

Aliases & Classifications for Kidney Hypertrophy

MalaCards integrated aliases for Kidney Hypertrophy:

Name: Kidney Hypertrophy 12 15
Hypertrophy of Kidney 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9622
ICD9CM 34 593.1
NCIt 49 C122991
SNOMED-CT 67 88531004
ICD10 32 N28.81
UMLS 71 C0156259

Summaries for Kidney Hypertrophy

MalaCards based summary : Kidney Hypertrophy, also known as hypertrophy of kidney, is related to chronic pyelonephritis and uremia. An important gene associated with Kidney Hypertrophy is NPHS1 (NPHS1 Adhesion Molecule, Nephrin), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers and Peptide hormone metabolism. Affiliated tissues include kidney, endothelial and bone, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Kidney Hypertrophy

Diseases related to Kidney Hypertrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 chronic pyelonephritis 29.8 REN ALB ACE
2 uremia 29.5 REN INS ALB ACE
3 microvascular complications of diabetes 3 29.2 REN NPHS1 INS CCN2 ALB ACE
4 hypothyroidism 29.1 REN INS ALB ACE
5 kidney disease 28.1 REN NPHS2 NPHS1 INS FN1 CCN2
6 chronic kidney disease 27.5 REN NPHS2 NPHS1 KL INS FN1
7 nephrotic syndrome, type 2 10.5 NPHS2 NPHS1
8 oligomeganephronia 10.4 NPHS2 NPHS1
9 congenital syphilis 10.4 NPHS2 NPHS1
10 critical illness polyneuropathy 10.4 INS ALB
11 pauci-immune glomerulonephritis 10.4 SYNPO CCN2
12 focal segmental glomerulosclerosis 2 10.4 NPHS2 NPHS1
13 retinal microaneurysm 10.4 REN INS
14 inflammatory and toxic neuropathy 10.4 INS ALB
15 mediastinitis 10.4 INS ALB
16 hemoglobin d disease 10.4 NPHS1 ALB
17 marasmus 10.3 INS ALB
18 autoimmune disease of urogenital tract 10.3 SYNPO NPHS1 ALB
19 focal segmental glomerulosclerosis 1 10.3 NPHS2 NPHS1
20 galloway-mowat syndrome 1 10.3 SYNPO NPHS2 NPHS1
21 galloway-mowat syndrome 10.3 SYNPO NPHS2 NPHS1
22 diffuse mesangial sclerosis 10.3 NPHS2 NPHS1
23 scleredema adultorum 10.3 INS FN1
24 decubitus ulcer 10.3 INS FN1 ALB
25 diffuse idiopathic skeletal hyperostosis 10.3 INS FN1 ALB
26 autonomic neuropathy 10.3 REN INS ALB
27 chronic ulcer of skin 10.3 INS FN1 ALB
28 hypoaldosteronism 10.3 REN ACE
29 renal artery obstruction 10.3 REN ACE
30 hypertension, diastolic 10.3 REN ACE
31 ovarian hyperstimulation syndrome 10.3 REN INS ALB
32 duodenitis 10.3 INS ALB
33 acute diffuse nephritis 10.3 FN1 ACE
34 cholesterol embolism 10.3 REN ACE
35 kwashiorkor 10.2 INS ALB
36 crescentic glomerulonephritis 10.2 SYNPO NPHS2 CCN2
37 silent myocardial infarction 10.2 INS ACE
38 intracranial embolism 10.2 ALB ACE
39 hyperuricemia 10.2 REN INS ALB
40 hypertensive nephropathy 10.2 ALB ACE
41 idiopathic edema 10.2 INS ACE
42 iga nephropathy 1 10.2 NPHS2 NPHS1 ACE
43 idiopathic nephrotic syndrome 10.2 NPHS2 ALB ACE
44 fibromuscular dysplasia 10.2 REN ACE
45 arteriolosclerosis 10.2 REN ALB
46 constrictive pericarditis 10.2 ALB ACE
47 orthostatic proteinuria 10.2 REN ALB ACE
48 posterior urethral valves 10.2 ACE2 ACE
49 hypertensive encephalopathy 10.2 REN ALB ACE
50 kidney papillary necrosis 10.2 REN ALB ACE

Comorbidity relations with Kidney Hypertrophy via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Kidney Hypertrophy:



Diseases related to Kidney Hypertrophy

Symptoms & Phenotypes for Kidney Hypertrophy

MGI Mouse Phenotypes related to Kidney Hypertrophy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.15 ACE ACE2 ALB CCN2 FN1 HNRNPF
2 growth/size/body region MP:0005378 10.1 ACE ACE2 ARAP1 CCN2 FN1 INS
3 homeostasis/metabolism MP:0005376 10.07 ACE ACE2 ALB CCN2 FN1 HNRNPF
4 mortality/aging MP:0010768 9.93 ACE ACE2 ALB CCN2 FN1 INS
5 muscle MP:0005369 9.56 ACE2 ALB FN1 INS KL NOX4
6 renal/urinary system MP:0005367 9.36 ACE ACE2 ALB HNRNPF INS KL

Drugs & Therapeutics for Kidney Hypertrophy

Search Clinical Trials , NIH Clinical Center for Kidney Hypertrophy

Genetic Tests for Kidney Hypertrophy

Anatomical Context for Kidney Hypertrophy

MalaCards organs/tissues related to Kidney Hypertrophy:

40
Kidney, Endothelial, Bone, Bone Marrow, Cortex, Heart, Liver

Publications for Kidney Hypertrophy

Articles related to Kidney Hypertrophy:

(show top 50) (show all 215)
# Title Authors PMID Year
1
Antioxidant and vasorelaxant effects of aqueous extract of large cardamom in L-NAME induced hypertensive rats. 61
32202168 2020
2
Eight weeks of treatment with nandrolone decanoate in female rats promotes disruption in the redox homeostasis and impaired renal function. 61
31881226 2020
3
Ophiopogonin D of Ophiopogon japonicus ameliorates renal function by suppressing oxidative stress and inflammatory response in streptozotocin-induced diabetic nephropathy rats. 61
32520209 2020
4
Coptisine ameliorates renal injury in diabetic rats through the activation of Nrf2 signaling pathway. 61
31420722 2020
5
Genetic characterization of early renal changes in a novel mouse model of diabetic kidney disease. 61
31420193 2019
6
Reversal of cardiac, vascular, and renal dysfunction by non-quinazoline α1-adrenolytics in DOCA-salt hypertensive rats: a comparison with prazosin, a quinazoline-based α1-adrenoceptor antagonist. 61
30872813 2019
7
Mangosteen Vinegar Rind from Garcinia mangostana Prevents High-Fat Diet and Streptozotocin-Induced Type II Diabetes Nephropathy and Apoptosis. 61
31012974 2019
8
DUSP1 recuses diabetic nephropathy via repressing JNK-Mff-mitochondrial fission pathways. 61
30191967 2019
9
Artemether ameliorates type 2 diabetic kidney disease by increasing mitochondrial pyruvate carrier content in db/db mice. 61
30972169 2019
10
Juzentaihoto hot water extract alleviates muscle atrophy and improves motor function in streptozotocin-induced diabetic oxidative stress mice. 61
30478793 2019
11
Niclosamide ethanolamine improves kidney injury in db/db mice. 61
30081104 2018
12
Antidiabetic and renoprotective effect of Anogeissus acuminata leaf extract on experimentally induced diabetic nephropathy. 61
29617268 2018
13
Ureteric entrapment in sacroiliac joint causing hydroureter and ipsilateral kidney hypertrophy. 61
29222673 2018
14
Chronic intermittent hypoxia exposure induces kidney injury in growing rats. 61
29124628 2018
15
Linagliptin unmasks specific antioxidant pathways protective against albuminuria and kidney hypertrophy in a mouse model of diabetes. 61
29979777 2018
16
NR4A1 Promotes Diabetic Nephropathy by Activating Mff-Mediated Mitochondrial Fission and Suppressing Parkin-Mediated Mitophagy. 61
30077998 2018
17
Inhibition of Akt/mTOR/p70S6K Signaling Activity With Huangkui Capsule Alleviates the Early Glomerular Pathological Changes in Diabetic Nephropathy. 61
29881349 2018
18
Renal-protective effect of thalidomide in streptozotocin-induced diabetic rats through anti-inflammatory pathway. 61
29386886 2018
19
Correlation of whole kidney hypertrophy with glomerular over-filtration in live, gender-mismatched renal transplant allografts. 61
27576505 2017
20
FSGS as an Adaptive Response to Growth-Induced Podocyte Stress. 61
28720684 2017
21
Insulin replacement limits progression of diabetic cardiomyopathy in the low-dose streptozotocin-induced diabetic rat. 61
28565941 2017
22
Attenuation of diabetic nephropathy in streptozotocin-induced diabetic rats by Punica granatum Linn. leaves extract. 61
28725620 2017
23
Compensatory Structural and Functional Adaptation After Nephrectomy in Obese Patients According to Waist Circumference. 61
28232178 2017
24
Blockade of RAGE in Zucker obese rats with experimental periodontitis. 61
26971526 2017
25
NADPH oxidase-2 mediates zinc deficiency-induced oxidative stress and kidney damage. 61
27806940 2017
26
Renal sympathetic denervation attenuates hypertension and vascular remodeling in renovascular hypertensive rats. 61
27742806 2017
27
Influence of Dipeptidyl Peptidase-IV Inhibitor Sitagliptin on Extracellular Signal-Regulated Kinases 1/2 Signaling in Rats with Diabetic Nephropathy. 61
28329747 2017
28
Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway. 61
29312514 2017
29
Progression of Chronic Kidney Disease After Acute Kidney Injury: Role of Self-Perpetuating Versus Hemodynamic-Induced Fibrosis. 61
27550923 2016
30
Xuezhikang () reduced renal cell apoptosis in streptozocin-induced diabetic rats through regulation of Bcl-2 family. 61
25847779 2016
31
Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats. 61
27153202 2016
32
Renoprotective effect of diosgenin in streptozotocin induced diabetic rats. 61
26922541 2016
33
Renoprotective Effects of Atorvastatin in Diabetic Mice: Downregulation of RhoA and Upregulation of Akt/GSK3. 61
27649495 2016
34
Amelioration of Renal Inflammation, Endoplasmic Reticulum Stress and Apoptosis Underlies the Protective Effect of Low Dosage of Atorvastatin in Gentamicin-Induced Nephrotoxicity. 61
27727327 2016
35
Sexual maturation and changes in water and salt transport components in the kidney and intestine of three-spined stickleback (Gasterosteus aculeatus L.). 61
26135640 2015
36
Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity. 61
26147382 2015
37
Klotho gene delivery ameliorates renal hypertrophy and fibrosis in streptozotocin-induced diabetic rats by suppressing the Rho-associated coiled-coil kinase signaling pathway. 61
25695625 2015
38
Deletion of the gene for adiponectin accelerates diabetic nephropathy in the Ins2 (+/C96Y) mouse. 61
25957229 2015
39
Effect of Cyclophosphamide on Expression of MMP-9 and TGF-β1 in Renal Tissue of Rats with Diabetes Mellitus. 61
25556071 2015
40
[Protective effect of astragalus saponin extracts on kidneys of diabetic rats]. 61
26390666 2015
41
Short-term treatment with diminazene aceturate ameliorates the reduction in kidney ACE2 activity in rats with subtotal nephrectomy. 61
25786223 2015
42
Activation of glycogen synthase kinase 3β ameliorates diabetes-induced kidney injury. 61
25339176 2014
43
Protective effect of pioglitazone on kidney injury in diabetic rats. 61
25129467 2014
44
[Untold stories of kidney metabolism]. 61
25315727 2014
45
Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation. 61
24670409 2014
46
[Causes of death in STZ-induced rat models of diabetes mellitus]. 61
25286701 2014
47
Estimating podocyte number and density using a single histologic section. 61
24357669 2014
48
Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy. 61
24680677 2014
49
Calcineurin Aβ regulates NADPH oxidase (Nox) expression and activity via nuclear factor of activated T cells (NFAT) in response to high glucose. 61
24371139 2014
50
Inhibition of sodium-linked glucose reabsorption normalizes diabetes-induced glomerular hyperfiltration in conscious adenosine A₁-receptor deficient mice. 61
23901799 2014

Variations for Kidney Hypertrophy

Expression for Kidney Hypertrophy

Search GEO for disease gene expression data for Kidney Hypertrophy.

Pathways for Kidney Hypertrophy

GO Terms for Kidney Hypertrophy

Cellular components related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 REN KL INS FN1 CCN2 ALB
2 plasma membrane GO:0005886 9.93 REN PPP3CB PODXL NPHS2 NPHS1 NOX4
3 extracellular exosome GO:0070062 9.86 PODXL NPHS2 NPHS1 KL FN1 ALB
4 apical plasma membrane GO:0016324 9.62 PODXL NOX4 KL FN1
5 extracellular space GO:0005615 9.61 REN PODXL KL INS FN1 CCN2
6 slit diaphragm GO:0036057 8.8 PODXL NPHS2 NPHS1

Biological processes related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.58 REN ODC1 ACE
2 fibroblast growth factor receptor signaling pathway GO:0008543 9.43 KL HNRNPF CCN2
3 amyloid-beta metabolic process GO:0050435 9.37 REN ACE
4 positive regulation of cardiac muscle contraction GO:0060452 9.32 CCN2 ACE2
5 glomerular visceral epithelial cell development GO:0072015 9.16 PODXL NPHS1
6 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.96 ACE2 ACE
7 angiotensin maturation GO:0002003 8.8 REN ACE2 ACE

Molecular functions related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 9.43 REN ACE2 ACE
2 dipeptidyl-peptidase activity GO:0008239 9.37 ACE2 ACE
3 drug binding GO:0008144 9.33 PPP3CB ALB ACE
4 insulin-like growth factor receptor binding GO:0005159 9.32 REN INS
5 exopeptidase activity GO:0008238 8.96 ACE2 ACE
6 peptidyl-dipeptidase activity GO:0008241 8.62 ACE2 ACE

Sources for Kidney Hypertrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....