MCID: KDN013
MIFTS: 35

Kidney Hypertrophy

Categories: Nephrological diseases

Aliases & Classifications for Kidney Hypertrophy

MalaCards integrated aliases for Kidney Hypertrophy:

Name: Kidney Hypertrophy 12 15
Hypertrophy of Kidney 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9622
ICD9CM 34 593.1
NCIt 49 C122991
SNOMED-CT 67 88531004
ICD10 32 N28.81
UMLS 71 C0156259

Summaries for Kidney Hypertrophy

MalaCards based summary : Kidney Hypertrophy, also known as hypertrophy of kidney, is related to chronic pyelonephritis and hydronephrosis. An important gene associated with Kidney Hypertrophy is NPHS1 (NPHS1 Adhesion Molecule, Nephrin), and among its related pathways/superpathways are Peptide hormone metabolism and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include kidney, endothelial and bone, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Kidney Hypertrophy

Diseases related to Kidney Hypertrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
# Related Disease Score Top Affiliating Genes
1 chronic pyelonephritis 29.9 REN ALB ACE
2 hydronephrosis 29.6 TGFB1 REN ALB
3 uremia 29.5 REN INS ALB ACE
4 microvascular complications of diabetes 3 28.6 TGFB1 REN NPHS1 INS CCN2 ALB
5 diabetes mellitus, insulin-dependent 28.5 REN NOS3 INS ALB ACE
6 chronic kidney disease 27.2 TGFB1 REN NPHS2 NPHS1 NOS3 INS
7 kidney disease 26.8 TGFB1 REN NPHS2 NPHS1 NOS3 INS
8 nephrotic syndrome, type 2 10.5 NPHS2 NPHS1
9 polycystic kidney disease 4 10.5 REN ALB
10 pauci-immune glomerulonephritis 10.4 SYNPO CCN2
11 critical illness polyneuropathy 10.4 INS ALB
12 retinal microaneurysm 10.4 REN INS
13 congenital syphilis 10.4 NPHS2 NPHS1
14 oligomeganephronia 10.4 NPHS2 NPHS1
15 inflammatory and toxic neuropathy 10.4 INS ALB
16 goodpasture syndrome 10.4 SYNPO NPHS1 ALB
17 focal segmental glomerulosclerosis 2 10.3 NPHS2 NPHS1
18 denys-drash syndrome 10.3 SYNPO NPHS2 NPHS1
19 benign essential hypertension 10.3 REN INS ALB
20 decubitus ulcer 10.3 INS FN1 ALB
21 diffuse idiopathic skeletal hyperostosis 10.3 INS FN1 ALB
22 autonomic neuropathy 10.3 REN INS ALB
23 chronic ulcer of skin 10.3 INS FN1 ALB
24 primary glomerular disease 10.3 TGFB1 ALB
25 hypoaldosteronism 10.3 REN ACE
26 renal artery obstruction 10.3 REN ACE
27 parathyroid gland disease 10.3 REN INS ALB
28 hypotrichosis 1 10.3 INS FN1 ALB
29 mediastinitis 10.3 INS ALB
30 ovarian hyperstimulation syndrome 10.3 REN INS ALB
31 galloway-mowat syndrome 10.3 SYNPO NPHS2 NPHS1
32 marasmus 10.3 INS ALB
33 crescentic glomerulonephritis 10.3 SYNPO NPHS2 CCN2
34 hypertension, diastolic 10.2 REN ACE
35 granulomatous hepatitis 10.2 ALB ACE
36 iga nephropathy 1 10.2 NPHS2 NPHS1 ACE
37 silent myocardial infarction 10.2 INS ACE
38 idiopathic nephrotic syndrome 10.2 NPHS2 ALB ACE
39 hyperuricemia 10.2 REN INS ALB
40 orthostatic proteinuria 10.2 REN ALB ACE
41 cholesterol embolism 10.2 REN ACE
42 kidney papillary necrosis 10.2 REN ALB ACE
43 hypertensive encephalopathy 10.2 REN ALB ACE
44 hypertensive retinopathy 10.2 REN ALB ACE
45 cardiac tamponade 10.2 REN ALB ACE
46 anuria 10.2 REN ALB ACE
47 aortic valve insufficiency 10.2 REN ALB ACE
48 pyelitis 10.2 REN ALB ACE
49 acute kidney tubular necrosis 10.2 REN ALB ACE
50 hepatorenal syndrome 10.2 REN ALB ACE

Comorbidity relations with Kidney Hypertrophy via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Kidney Hypertrophy:



Diseases related to Kidney Hypertrophy

Symptoms & Phenotypes for Kidney Hypertrophy

MGI Mouse Phenotypes related to Kidney Hypertrophy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 ACE ACE2 ALB CCN2 FMOD FN1
2 growth/size/body region MP:0005378 10.22 ACE ACE2 ARAP1 CCN2 FMOD FN1
3 homeostasis/metabolism MP:0005376 10.15 ACE ACE2 ALB CCN2 FN1 INS
4 cellular MP:0005384 10.13 ACE2 ALB CCN2 FMOD FN1 INS
5 mortality/aging MP:0010768 10.07 ACE ACE2 ALB CCN2 FN1 INS
6 liver/biliary system MP:0005370 9.87 ACE ALB CCN2 FN1 INS NOS3
7 muscle MP:0005369 9.81 ACE2 ALB FMOD FN1 INS NOS3
8 normal MP:0002873 9.56 ALB CCN2 FN1 INS NOS3 NPHS1
9 renal/urinary system MP:0005367 9.36 ACE ACE2 ALB INS NOS3 NOX4

Drugs & Therapeutics for Kidney Hypertrophy

Search Clinical Trials , NIH Clinical Center for Kidney Hypertrophy

Genetic Tests for Kidney Hypertrophy

Anatomical Context for Kidney Hypertrophy

MalaCards organs/tissues related to Kidney Hypertrophy:

40
Kidney, Endothelial, Bone, Bone Marrow, Cortex, Heart, Liver

Publications for Kidney Hypertrophy

Articles related to Kidney Hypertrophy:

(show top 50) (show all 212)
# Title Authors PMID Year
1
Genetic characterization of early renal changes in a novel mouse model of diabetic kidney disease. 61
31420193 2019
2
Coptisine ameliorates renal injury in diabetic rats through the activation of Nrf2 signaling pathway. 61
31420722 2019
3
Reversal of cardiac, vascular, and renal dysfunction by non-quinazoline α1-adrenolytics in DOCA-salt hypertensive rats: a comparison with prazosin, a quinazoline-based α1-adrenoceptor antagonist. 61
30872813 2019
4
Mangosteen Vinegar Rind from Garcinia mangostana Prevents High-Fat Diet and Streptozotocin-Induced Type II Diabetes Nephropathy and Apoptosis. 61
31012974 2019
5
DUSP1 recuses diabetic nephropathy via repressing JNK-Mff-mitochondrial fission pathways. 61
30191967 2019
6
Artemether ameliorates type 2 diabetic kidney disease by increasing mitochondrial pyruvate carrier content in db/db mice. 61
30972169 2019
7
Juzentaihoto hot water extract alleviates muscle atrophy and improves motor function in streptozotocin-induced diabetic oxidative stress mice. 61
30478793 2019
8
Niclosamide ethanolamine improves kidney injury in db/db mice. 61
30081104 2018
9
Antidiabetic and renoprotective effect of Anogeissus acuminata leaf extract on experimentally induced diabetic nephropathy. 61
29617268 2018
10
Ureteric entrapment in sacroiliac joint causing hydroureter and ipsilateral kidney hypertrophy. 61
29222673 2018
11
Chronic intermittent hypoxia exposure induces kidney injury in growing rats. 61
29124628 2018
12
Renal-protective effect of thalidomide in streptozotocin-induced diabetic rats through anti-inflammatory pathway. 61
29386886 2018
13
Inhibition of Akt/mTOR/p70S6K Signaling Activity With Huangkui Capsule Alleviates the Early Glomerular Pathological Changes in Diabetic Nephropathy. 61
29881349 2018
14
NR4A1 Promotes Diabetic Nephropathy by Activating Mff-Mediated Mitochondrial Fission and Suppressing Parkin-Mediated Mitophagy. 61
30077998 2018
15
Linagliptin unmasks specific antioxidant pathways protective against albuminuria and kidney hypertrophy in a mouse model of diabetes. 61
29979777 2018
16
Correlation of whole kidney hypertrophy with glomerular over-filtration in live, gender-mismatched renal transplant allografts. 61
27576505 2017
17
FSGS as an Adaptive Response to Growth-Induced Podocyte Stress. 61
28720684 2017
18
Insulin replacement limits progression of diabetic cardiomyopathy in the low-dose streptozotocin-induced diabetic rat. 61
28565941 2017
19
Attenuation of diabetic nephropathy in streptozotocin-induced diabetic rats by Punica granatum Linn. leaves extract. 61
28725620 2017
20
Compensatory Structural and Functional Adaptation After Nephrectomy in Obese Patients According to Waist Circumference. 61
28232178 2017
21
Blockade of RAGE in Zucker obese rats with experimental periodontitis. 61
26971526 2017
22
NADPH oxidase-2 mediates zinc deficiency-induced oxidative stress and kidney damage. 61
27806940 2017
23
Renal sympathetic denervation attenuates hypertension and vascular remodeling in renovascular hypertensive rats. 61
27742806 2017
24
Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway. 61
29312514 2017
25
Influence of Dipeptidyl Peptidase-IV Inhibitor Sitagliptin on Extracellular Signal-Regulated Kinases 1/2 Signaling in Rats with Diabetic Nephropathy. 61
28329747 2017
26
Progression of Chronic Kidney Disease After Acute Kidney Injury: Role of Self-Perpetuating Versus Hemodynamic-Induced Fibrosis. 61
27550923 2016
27
Xuezhikang () reduced renal cell apoptosis in streptozocin-induced diabetic rats through regulation of Bcl-2 family. 61
25847779 2016
28
Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats. 61
27153202 2016
29
Renoprotective effect of diosgenin in streptozotocin induced diabetic rats. 61
26922541 2016
30
Amelioration of Renal Inflammation, Endoplasmic Reticulum Stress and Apoptosis Underlies the Protective Effect of Low Dosage of Atorvastatin in Gentamicin-Induced Nephrotoxicity. 61
27727327 2016
31
Renoprotective Effects of Atorvastatin in Diabetic Mice: Downregulation of RhoA and Upregulation of Akt/GSK3. 61
27649495 2016
32
Sexual maturation and changes in water and salt transport components in the kidney and intestine of three-spined stickleback (Gasterosteus aculeatus L.). 61
26135640 2015
33
Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity. 61
26147382 2015
34
Klotho gene delivery ameliorates renal hypertrophy and fibrosis in streptozotocin-induced diabetic rats by suppressing the Rho-associated coiled-coil kinase signaling pathway. 61
25695625 2015
35
Deletion of the gene for adiponectin accelerates diabetic nephropathy in the Ins2 (+/C96Y) mouse. 61
25957229 2015
36
Effect of Cyclophosphamide on Expression of MMP-9 and TGF-β1 in Renal Tissue of Rats with Diabetes Mellitus. 61
25556071 2015
37
[Protective effect of astragalus saponin extracts on kidneys of diabetic rats]. 61
26390666 2015
38
Short-term treatment with diminazene aceturate ameliorates the reduction in kidney ACE2 activity in rats with subtotal nephrectomy. 61
25786223 2015
39
Activation of glycogen synthase kinase 3β ameliorates diabetes-induced kidney injury. 61
25339176 2014
40
Protective effect of pioglitazone on kidney injury in diabetic rats. 61
25129467 2014
41
[Untold stories of kidney metabolism]. 61
25315727 2014
42
Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation. 61
24670409 2014
43
[Causes of death in STZ-induced rat models of diabetes mellitus]. 61
25286701 2014
44
Estimating podocyte number and density using a single histologic section. 61
24357669 2014
45
Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy. 61
24680677 2014
46
Calcineurin Aβ regulates NADPH oxidase (Nox) expression and activity via nuclear factor of activated T cells (NFAT) in response to high glucose. 61
24371139 2014
47
Inhibition of sodium-linked glucose reabsorption normalizes diabetes-induced glomerular hyperfiltration in conscious adenosine A₁-receptor deficient mice. 61
23901799 2014
48
Dung-Shen Downregulates the Synergistic Apoptotic Effects of Angiotensin II Plus Leu 27-IGF II on Cardiomyoblasts. 61
27122769 2014
49
Puerarin attenuated early diabetic kidney injury through down-regulation of matrix metalloproteinase 9 in streptozotocin-induced diabetic rats. 61
24454919 2014
50
Withania coagulans fruit extract reduces oxidative stress and inflammation in kidneys of streptozotocin-induced diabetic rats. 61
25295146 2014

Variations for Kidney Hypertrophy

Expression for Kidney Hypertrophy

Search GEO for disease gene expression data for Kidney Hypertrophy.

Pathways for Kidney Hypertrophy

GO Terms for Kidney Hypertrophy

Cellular components related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.03 TGFB1 SYNPO REN PODXL NPHS2 NPHS1
2 extracellular region GO:0005576 9.81 TGFB1 REN INS FN1 FMOD CCN2
3 extracellular matrix GO:0031012 9.67 TGFB1 FN1 FMOD CCN2
4 extracellular space GO:0005615 9.65 TGFB1 REN PODXL INS FN1 FMOD
5 Golgi lumen GO:0005796 9.58 TGFB1 INS FMOD
6 platelet alpha granule lumen GO:0031093 9.5 TGFB1 FN1 ALB
7 slit diaphragm GO:0036057 8.8 PODXL NPHS2 NPHS1

Biological processes related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.91 TGFB1 ODC1 INS FN1 CCN2
2 positive regulation of gene expression GO:0010628 9.8 TGFB1 NOS3 INS FN1 CCN2
3 kidney development GO:0001822 9.75 REN ODC1 ACE
4 wound healing GO:0042060 9.71 TGFB1 INS FN1
5 response to wounding GO:0009611 9.67 TGFB1 FN1 CCN2
6 regulation of blood pressure GO:0008217 9.61 REN NOS3 ACE
7 positive regulation of cellular protein metabolic process GO:0032270 9.57 TGFB1 INS
8 amyloid-beta metabolic process GO:0050435 9.56 REN ACE
9 negative regulation of cell-cell adhesion GO:0022408 9.55 TGFB1 PODXL
10 positive regulation of cardiac muscle contraction GO:0060452 9.52 CCN2 ACE2
11 negative regulation of biomineral tissue development GO:0070168 9.48 TGFB1 NOS3
12 glomerular visceral epithelial cell development GO:0072015 9.46 PODXL NPHS1
13 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.37 ACE2 ACE
14 connective tissue development GO:0061448 9.32 TGFB1 CCN2
15 negative regulation of protein oligomerization GO:0032460 9.26 INS ALB
16 mononuclear cell proliferation GO:0032943 9.16 TGFB1 ACE
17 regulation of blood vessel diameter GO:0097746 9.13 NOS3 ACE2 ACE
18 angiotensin maturation GO:0002003 8.8 REN ACE2 ACE

Molecular functions related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 9.33 REN ACE2 ACE
2 dipeptidyl-peptidase activity GO:0008239 9.32 ACE2 ACE
3 insulin-like growth factor receptor binding GO:0005159 9.26 REN INS
4 exopeptidase activity GO:0008238 8.96 ACE2 ACE
5 peptidyl-dipeptidase activity GO:0008241 8.62 ACE2 ACE

Sources for Kidney Hypertrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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