MCID: KDN013
MIFTS: 27

Kidney Hypertrophy

Categories: Nephrological diseases

Aliases & Classifications for Kidney Hypertrophy

MalaCards integrated aliases for Kidney Hypertrophy:

Name: Kidney Hypertrophy 12 15
Hypertrophy of Kidney 72

Classifications:



External Ids:

Disease Ontology 12 DOID:9622
ICD9CM 35 593.1
NCIt 50 C122991
SNOMED-CT 68 88531004
ICD10 33 N28.81
UMLS 72 C0156259

Summaries for Kidney Hypertrophy

MalaCards based summary : Kidney Hypertrophy, also known as hypertrophy of kidney, is related to microvascular complications of diabetes 3 and kidney disease. An important gene associated with Kidney Hypertrophy is ALB (Albumin), and among its related pathways/superpathways are Primary Focal Segmental Glomerulosclerosis FSGS and Nephrin/Neph1 signaling in the kidney podocyte. Affiliated tissues include kidney, endothelial and bone.

Related Diseases for Kidney Hypertrophy

Diseases related to Kidney Hypertrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 3 30.2 NPHS1 ALB
2 kidney disease 28.3 NPHS2 NPHS1 ALB
3 non-secretory myeloma 10.4 FN1 ALB
4 arcus corneae 10.2 FN1 ALB
5 analbuminemia 10.2 NPHS1 ALB
6 membranoproliferative glomerulonephritis 10.2 NPHS1 ALB
7 nephrotic syndrome, type 6 10.0 NPHS2 NPHS1
8 hypoparathyroidism, sensorineural deafness, and renal disease 10.0 NPHS2 NPHS1
9 familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis 10.0 NPHS2 NPHS1
10 atrial septal defect 3 10.0 NPHS2 NPHS1
11 familial nephrotic syndrome 10.0 NPHS2 NPHS1
12 nephrotic syndrome, type 1 10.0 NPHS2 NPHS1
13 trypanosomiasis 10.0 ODC1 ALB
14 denys-drash syndrome 9.9 NPHS2 NPHS1
15 diffuse mesangial sclerosis 9.9 NPHS2 NPHS1
16 nephrosclerosis 9.9 NPHS2 NPHS1
17 microvascular complications of diabetes 4 9.9
18 microvascular complications of diabetes 6 9.9
19 microvascular complications of diabetes 7 9.9
20 lipoid nephrosis 9.8 NPHS2 NPHS1 ALB
21 galloway-mowat syndrome 9.8 NPHS2 NPHS1
22 iga glomerulonephritis 9.8 NPHS2 NPHS1 ALB
23 glomerulonephritis 9.8 NPHS2 NPHS1 ALB
24 membranous nephropathy 9.8 NPHS2 NPHS1 ALB
25 urinary system disease 9.8 NPHS2 NPHS1 ALB
26 nephrotic syndrome 9.8 NPHS2 NPHS1 ALB
27 frasier syndrome 9.7 NPHS2 NPHS1
28 diabetes mellitus, insulin-dependent 9.7
29 insulin-like growth factor i 9.7
30 chronic pyelonephritis 9.7
31 hydronephrosis 9.7
32 pyelonephritis 9.7
33 bronchopneumonia 9.7
34 hypothyroidism 9.7
35 arteriosclerosis 9.7
36 uremia 9.7
37 chronic kidney disease 9.7
38 47,xyy 9.7
39 focal segmental glomerulosclerosis 9.7 NPHS2 NPHS1 ALB
40 end stage renal failure 9.5 NPHS2 NPHS1 FN1 ALB

Comorbidity relations with Kidney Hypertrophy via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Kidney Hypertrophy:



Diseases related to Kidney Hypertrophy

Symptoms & Phenotypes for Kidney Hypertrophy

Drugs & Therapeutics for Kidney Hypertrophy

Search Clinical Trials , NIH Clinical Center for Kidney Hypertrophy

Genetic Tests for Kidney Hypertrophy

Anatomical Context for Kidney Hypertrophy

MalaCards organs/tissues related to Kidney Hypertrophy:

41
Kidney, Endothelial, Bone, Liver, Heart, Bone Marrow, Cortex

Publications for Kidney Hypertrophy

Articles related to Kidney Hypertrophy:

(show top 50) (show all 212)
# Title Authors PMID Year
1
Coptisine ameliorates renal injury in diabetic rats through the activation of Nrf2 signaling pathway. 38
31420722 2019
2
Reversal of cardiac, vascular, and renal dysfunction by non-quinazoline α1-adrenolytics in DOCA-salt hypertensive rats: a comparison with prazosin, a quinazoline-based α1-adrenoceptor antagonist. 38
30872813 2019
3
Mangosteen Vinegar Rind from Garcinia mangostana Prevents High-Fat Diet and Streptozotocin-Induced Type II Diabetes Nephropathy and Apoptosis. 38
31012974 2019
4
Genetic characterization of early renal changes in a novel mouse model of diabetic kidney disease. 38
31420193 2019
5
DUSP1 recuses diabetic nephropathy via repressing JNK-Mff-mitochondrial fission pathways. 38
30191967 2019
6
Artemether ameliorates type 2 diabetic kidney disease by increasing mitochondrial pyruvate carrier content in db/db mice. 38
30972169 2019
7
Juzentaihoto hot water extract alleviates muscle atrophy and improves motor function in streptozotocin-induced diabetic oxidative stress mice. 38
30478793 2019
8
Niclosamide ethanolamine improves kidney injury in db/db mice. 38
30081104 2018
9
Antidiabetic and renoprotective effect of Anogeissus acuminata leaf extract on experimentally induced diabetic nephropathy. 38
29617268 2018
10
Ureteric entrapment in sacroiliac joint causing hydroureter and ipsilateral kidney hypertrophy. 38
29222673 2018
11
Chronic intermittent hypoxia exposure induces kidney injury in growing rats. 38
29124628 2018
12
Linagliptin unmasks specific antioxidant pathways protective against albuminuria and kidney hypertrophy in a mouse model of diabetes. 38
29979777 2018
13
NR4A1 Promotes Diabetic Nephropathy by Activating Mff-Mediated Mitochondrial Fission and Suppressing Parkin-Mediated Mitophagy. 38
30077998 2018
14
Inhibition of Akt/mTOR/p70S6K Signaling Activity With Huangkui Capsule Alleviates the Early Glomerular Pathological Changes in Diabetic Nephropathy. 38
29881349 2018
15
Renal-protective effect of thalidomide in streptozotocin-induced diabetic rats through anti-inflammatory pathway. 38
29386886 2018
16
Correlation of whole kidney hypertrophy with glomerular over-filtration in live, gender-mismatched renal transplant allografts. 38
27576505 2017
17
FSGS as an Adaptive Response to Growth-Induced Podocyte Stress. 38
28720684 2017
18
Insulin replacement limits progression of diabetic cardiomyopathy in the low-dose streptozotocin-induced diabetic rat. 38
28565941 2017
19
Attenuation of diabetic nephropathy in streptozotocin-induced diabetic rats by Punica granatum Linn. leaves extract. 38
28725620 2017
20
Compensatory Structural and Functional Adaptation After Nephrectomy in Obese Patients According to Waist Circumference. 38
28232178 2017
21
Blockade of RAGE in Zucker obese rats with experimental periodontitis. 38
26971526 2017
22
NADPH oxidase-2 mediates zinc deficiency-induced oxidative stress and kidney damage. 38
27806940 2017
23
Renal sympathetic denervation attenuates hypertension and vascular remodeling in renovascular hypertensive rats. 38
27742806 2017
24
Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway. 38
29312514 2017
25
Influence of Dipeptidyl Peptidase-IV Inhibitor Sitagliptin on Extracellular Signal-Regulated Kinases 1/2 Signaling in Rats with Diabetic Nephropathy. 38
28329747 2017
26
Progression of Chronic Kidney Disease After Acute Kidney Injury: Role of Self-Perpetuating Versus Hemodynamic-Induced Fibrosis. 38
27550923 2016
27
Xuezhikang () reduced renal cell apoptosis in streptozocin-induced diabetic rats through regulation of Bcl-2 family. 38
25847779 2016
28
Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats. 38
27153202 2016
29
Renoprotective effect of diosgenin in streptozotocin induced diabetic rats. 38
26922541 2016
30
Renoprotective Effects of Atorvastatin in Diabetic Mice: Downregulation of RhoA and Upregulation of Akt/GSK3. 38
27649495 2016
31
Amelioration of Renal Inflammation, Endoplasmic Reticulum Stress and Apoptosis Underlies the Protective Effect of Low Dosage of Atorvastatin in Gentamicin-Induced Nephrotoxicity. 38
27727327 2016
32
Sexual maturation and changes in water and salt transport components in the kidney and intestine of three-spined stickleback (Gasterosteus aculeatus L.). 38
26135640 2015
33
Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity. 38
26147382 2015
34
Klotho gene delivery ameliorates renal hypertrophy and fibrosis in streptozotocin-induced diabetic rats by suppressing the Rho-associated coiled-coil kinase signaling pathway. 38
25695625 2015
35
Deletion of the gene for adiponectin accelerates diabetic nephropathy in the Ins2 (+/C96Y) mouse. 38
25957229 2015
36
Effect of Cyclophosphamide on Expression of MMP-9 and TGF-β1 in Renal Tissue of Rats with Diabetes Mellitus. 38
25556071 2015
37
[Protective effect of astragalus saponin extracts on kidneys of diabetic rats]. 38
26390666 2015
38
Short-term treatment with diminazene aceturate ameliorates the reduction in kidney ACE2 activity in rats with subtotal nephrectomy. 38
25786223 2015
39
Activation of glycogen synthase kinase 3β ameliorates diabetes-induced kidney injury. 38
25339176 2014
40
Protective effect of pioglitazone on kidney injury in diabetic rats. 38
25129467 2014
41
[Untold stories of kidney metabolism]. 38
25315727 2014
42
Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation. 38
24670409 2014
43
[Causes of death in STZ-induced rat models of diabetes mellitus]. 38
25286701 2014
44
Estimating podocyte number and density using a single histologic section. 38
24357669 2014
45
Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy. 38
24680677 2014
46
Calcineurin Aβ regulates NADPH oxidase (Nox) expression and activity via nuclear factor of activated T cells (NFAT) in response to high glucose. 38
24371139 2014
47
Inhibition of sodium-linked glucose reabsorption normalizes diabetes-induced glomerular hyperfiltration in conscious adenosine A₁-receptor deficient mice. 38
23901799 2014
48
Dung-Shen Downregulates the Synergistic Apoptotic Effects of Angiotensin II Plus Leu 27-IGF II on Cardiomyoblasts. 38
27122769 2014
49
Puerarin attenuated early diabetic kidney injury through down-regulation of matrix metalloproteinase 9 in streptozotocin-induced diabetic rats. 38
24454919 2014
50
Withania coagulans fruit extract reduces oxidative stress and inflammation in kidneys of streptozotocin-induced diabetic rats. 38
25295146 2014

Variations for Kidney Hypertrophy

Expression for Kidney Hypertrophy

Search GEO for disease gene expression data for Kidney Hypertrophy.

Pathways for Kidney Hypertrophy

Pathways related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.82 NPHS2 NPHS1
2 10.04 NPHS2 NPHS1

GO Terms for Kidney Hypertrophy

Cellular components related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.96 FN1 ALB
2 slit diaphragm GO:0036057 8.62 NPHS2 NPHS1

Biological processes related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 excretion GO:0007588 9.16 NPHS2 NPHS1
2 exogenous drug catabolic process GO:0042738 8.96 CYP2U1 CYP2F1
3 organic acid metabolic process GO:0006082 8.62 CYP2U1 CYP2F1

Molecular functions related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.37 CYP2U1 CYP2F1
2 monooxygenase activity GO:0004497 9.32 CYP2U1 CYP2F1
3 oxygen binding GO:0019825 9.26 CYP2F1 ALB
4 steroid hydroxylase activity GO:0008395 9.16 CYP2U1 CYP2F1
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 8.96 CYP2U1 CYP2F1
6 aromatase activity GO:0070330 8.62 CYP2U1 CYP2F1

Sources for Kidney Hypertrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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