MCID: KDN013
MIFTS: 27

Kidney Hypertrophy

Categories: Nephrological diseases

Aliases & Classifications for Kidney Hypertrophy

MalaCards integrated aliases for Kidney Hypertrophy:

Name: Kidney Hypertrophy 12 15
Hypertrophy of Kidney 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9622
ICD10 33 N28.81
ICD9CM 35 593.1
NCIt 50 C122991
SNOMED-CT 68 197800004 88531004
UMLS 73 C0156259

Summaries for Kidney Hypertrophy

MalaCards based summary : Kidney Hypertrophy, also known as hypertrophy of kidney, is related to ascending cholangitis and cholecystolithiasis. An important gene associated with Kidney Hypertrophy is ALB (Albumin), and among its related pathways/superpathways are Lung fibrosis and TGF-beta receptor signaling (Pathway Interaction Database). Affiliated tissues include kidney, and related phenotype is mortality/aging.

Related Diseases for Kidney Hypertrophy

Diseases related to Kidney Hypertrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 ascending cholangitis 10.4 ALB TGFB1
2 cholecystolithiasis 10.3 CTGF TGFB1
3 stiff skin syndrome 10.3 CTGF TGFB1
4 hydronephrosis 10.2 ALB TGFB1
5 gingival disease 10.2 CTGF TGFB1
6 analbuminemia 10.2 ALB NPHS1
7 retinal vascular disease 10.2 ALB CTGF
8 localized scleroderma 10.2 CTGF TGFB1
9 nephrogenic systemic fibrosis 10.2 CTGF TGFB1
10 ureteral disease 10.2 CTGF TGFB1
11 ocular cicatricial pemphigoid 10.2 CTGF TGFB1
12 membranoproliferative glomerulonephritis 10.1 ALB NPHS1
13 vitreoretinopathy, neovascular inflammatory 10.1 CTGF TGFB1
14 carpal tunnel syndrome 10.1 CTGF TGFB1
15 familial idiopathic steroid-resistant nephrotic syndrome with minimal changes 10.1 NPHS1 NPHS2
16 gingival overgrowth 10.0 CTGF TGFB1
17 atrial septal defect 3 10.0 NPHS1 NPHS2
18 hypoparathyroidism, sensorineural deafness, and renal disease 10.0 NPHS1 NPHS2
19 familial nephrotic syndrome 10.0 NPHS1 NPHS2
20 nephrotic syndrome, type 1 10.0 NPHS1 NPHS2
21 focal segmental glomerulosclerosis 1 10.0 NPHS1 NPHS2
22 denys-drash syndrome 10.0 NPHS1 NPHS2
23 sialolithiasis 9.9 ALB CTGF TGFB1
24 urinary tract obstruction 9.9 ALB CTGF TGFB1
25 biliary atresia 9.9 ALB CTGF TGFB1
26 gingival fibromatosis 9.9 CTGF TGFB1
27 frasier syndrome 9.8 NPHS1 NPHS2
28 idiopathic interstitial pneumonia 9.8 CTGF TGFB1
29 respiratory system disease 9.8 ALB TGFB1
30 galloway-mowat syndrome 9.8 NPHS1 NPHS2
31 nephrosclerosis 9.7 CTGF NPHS2 TGFB1
32 lipoid nephrosis 9.7 ALB NPHS1 NPHS2
33 nephrotic syndrome 9.7 ALB NPHS1 NPHS2
34 aging 9.6
35 chronic pyelonephritis 9.6
36 pyelonephritis 9.6
37 bronchopneumonia 9.6
38 arteriosclerosis 9.6
39 uremia 9.6
40 renal fibrosis 9.5 CTGF TGFB1
41 diffuse mesangial sclerosis 9.5 NPHS1 NPHS2 TGFB1
42 microvascular complications of diabetes 3 9.2 ALB CTGF NPHS1 TGFB1
43 end stage renal failure 9.1 ALB NPHS1 NPHS2 TGFB1
44 iga glomerulonephritis 9.1 ALB NPHS1 NPHS2 TGFB1
45 membranous nephropathy 9.1 ALB NPHS1 NPHS2 TGFB1
46 glomerulonephritis 9.1 ALB NPHS1 NPHS2 TGFB1
47 chronic kidney failure 9.1 ALB NPHS1 NPHS2 TGFB1
48 focal segmental glomerulosclerosis 9.1 ALB NPHS1 NPHS2 TGFB1
49 kidney disease 9.0 ALB NPHS1 NPHS2 TGFB1
50 urinary system disease 8.6 ALB CTGF NPHS1 NPHS2 TGFB1

Comorbidity relations with Kidney Hypertrophy via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Kidney Hypertrophy:



Diseases related to Kidney Hypertrophy

Symptoms & Phenotypes for Kidney Hypertrophy

MGI Mouse Phenotypes related to Kidney Hypertrophy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.17 ALB CTGF NHEJ1 NPHS1 NPHS2 ODC1

Drugs & Therapeutics for Kidney Hypertrophy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Matrix Metalloproteinases and Diabetic Nephropathy Completed NCT00067886

Search NIH Clinical Center for Kidney Hypertrophy

Genetic Tests for Kidney Hypertrophy

Anatomical Context for Kidney Hypertrophy

MalaCards organs/tissues related to Kidney Hypertrophy:

41
Kidney

Publications for Kidney Hypertrophy

Articles related to Kidney Hypertrophy:

(show all 25)
# Title Authors Year
1
Linagliptin unmasks specific antioxidant pathways protective against albuminuria and kidney hypertrophy in a mouse model of diabetes. ( 29979777 )
2018
2
Ureteric entrapment in sacroiliac joint causing hydroureter and ipsilateral kidney hypertrophy. ( 29222673 )
2017
3
Correlation of whole kidney hypertrophy with glomerular over-filtration in live, gender-mismatched renal transplant allografts. ( 27576505 )
2016
4
Stimulation of Sigma-1 receptor by dehydroepiandrosterone ameliorates hypertension-induced kidney hypertrophy in ovariectomized rats. ( 20404054 )
2010
5
Development of hypertension and kidney hypertrophy in transgenic mice overexpressing ARAP1 gene in the kidney. ( 16801480 )
2006
6
Effect of ammonium chloride and dietary phosphorus in the azotaemic rat. Part II--Kidney hypertrophy and calcium deposition. ( 15161952 )
2004
7
The juvenile three-spined stickleback (Gasterosteus aculeatus L.) as a model organism for endocrine disruption II--kidney hypertrophy, vitellogenin and spiggin induction. ( 15588642 )
2004
8
Renin-angiotensin system blockade prevents the increase in plasma transforming growth factor beta 1, and reduces proteinuria and kidney hypertrophy in the streptozotocin-diabetic rat. ( 15526251 )
2004
9
Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. ( 8603776 )
1996
10
An evaluation of the role of polyamines in different models of kidney hypertrophy in mice. ( 7474658 )
1995
11
Inhibition of renal ornithine decarboxylase activity fails to reduce kidney size and urinary albumin excretion in diabetic rats with manifest kidney hypertrophy. ( 7796931 )
1995
12
Renal proteinases and kidney hypertrophy in experimental diabetes. ( 7926340 )
1994
13
Inhibition of renal ornithine decarboxylase activity prevents kidney hypertrophy in experimental diabetes. ( 8447376 )
1993
14
Morphometric analysis of kidney hypertrophy in rats after chronic potassium depletion. ( 1566879 )
1992
15
Transient increase in renal insulin-like growth factor binding proteins during initial kidney hypertrophy in experimental diabetes in rats. ( 1377139 )
1992
16
Vasopressin-dependent kidney hypertrophy: role of urinary concentration in protein-induced hypertrophy and in the progression of chronic renal failure. ( 2042645 )
1991
17
Characterization of beta-adrenergic receptor subtypes in androgen-induced mouse kidney hypertrophy using a new high-affinity ligand, [125I]iodocyanopindolol. ( 6299377 )
1983
18
Increased beta-adrenergic receptor complement in androgen-induced mouse kidney hypertrophy. ( 6269651 )
1981
19
Regulation of compensatory kidney hypertrophy by its own products. ( 894611 )
1977
20
The influence of salt intake on glomerular count in compensatory kidney hypertrophy in rats of different ages. ( 954972 )
1976
21
Ornithine decarboxylase activity and polyamine synthesis during kidney hypertrophy. ( 4119904 )
1972
22
Immunochemical studies on kidney hypertrophy of the rat. ( 13954727 )
1962
23
WEEKLY clinicopathological exercises: chronic pyelonephritis severe (with uremia); atrophy of the right kidney, hypertrophy of left; bronchopneumonia; aortic arteriosclerosis, severe, ascending arch, with short localized dissection; calcareous aortic stenosis. ( 14863577 )
1951
24
Kidney hypertrophy in B complex deficiency. ( 21024173 )
1946
25
THE PRODUCTION OF HYPERTENSION BY THE PREVENTION OF KIDNEY HYPERTROPHY: (Preliminary Report). ( 20321520 )
1939

Variations for Kidney Hypertrophy

Expression for Kidney Hypertrophy

Search GEO for disease gene expression data for Kidney Hypertrophy.

Pathways for Kidney Hypertrophy

Pathways related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.06 CTGF TGFB1
2 10.86 CTGF TGFB1
3 10.67 NPHS1 NPHS2 TGFB1
4 10.37 NPHS1 NPHS2

GO Terms for Kidney Hypertrophy

Cellular components related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.96 ALB TGFB1
2 slit diaphragm GO:0036057 8.62 NPHS1 NPHS2

Biological processes related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell differentiation GO:0030217 9.16 NHEJ1 TGFB1
2 excretion GO:0007588 8.96 NPHS1 NPHS2
3 positive regulation of collagen biosynthetic process GO:0032967 8.62 CTGF TGFB1

Sources for Kidney Hypertrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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