MCID: KDN013
MIFTS: 25

Kidney Hypertrophy

Categories: Nephrological diseases

Aliases & Classifications for Kidney Hypertrophy

MalaCards integrated aliases for Kidney Hypertrophy:

Name: Kidney Hypertrophy 12 15
Hypertrophy of Kidney 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9622
ICD9CM 36 593.1
NCIt 51 C122991
SNOMED-CT 69 88531004
ICD10 34 N28.81
UMLS 74 C0156259

Summaries for Kidney Hypertrophy

MalaCards based summary : Kidney Hypertrophy, also known as hypertrophy of kidney, is related to non-secretory myeloma and arcus corneae. An important gene associated with Kidney Hypertrophy is ALB (Albumin), and among its related pathways/superpathways are Primary Focal Segmental Glomerulosclerosis FSGS and Nephrin/Neph1 signaling in the kidney podocyte. Affiliated tissues include kidney.

Related Diseases for Kidney Hypertrophy

Diseases related to Kidney Hypertrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 non-secretory myeloma 10.3 ALB FN1
2 arcus corneae 10.2 ALB FN1
3 microvascular complications of diabetes 3 10.1 ALB NPHS1
4 analbuminemia 10.0 ALB NPHS1
5 trypanosomiasis 10.0 ALB ODC1
6 nephrotic syndrome, type 6 10.0 NPHS1 NPHS2
7 hypoparathyroidism, sensorineural deafness, and renal disease 10.0 NPHS1 NPHS2
8 membranoproliferative glomerulonephritis 10.0 ALB NPHS1
9 atrial septal defect 3 10.0 NPHS1 NPHS2
10 familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis 10.0 NPHS1 NPHS2
11 familial nephrotic syndrome 10.0 NPHS1 NPHS2
12 muscle hypertrophy 9.9
13 nephrotic syndrome, type 1 9.9 NPHS1 NPHS2
14 denys-drash syndrome 9.9 NPHS1 NPHS2
15 diffuse mesangial sclerosis 9.9 NPHS1 NPHS2
16 nephrosclerosis 9.9 NPHS1 NPHS2
17 lipoid nephrosis 9.8 ALB NPHS1 NPHS2
18 iga glomerulonephritis 9.8 ALB NPHS1 NPHS2
19 glomerulonephritis 9.8 ALB NPHS1 NPHS2
20 galloway-mowat syndrome 9.8 NPHS1 NPHS2
21 membranous nephropathy 9.8 ALB NPHS1 NPHS2
22 urinary system disease 9.8 ALB NPHS1 NPHS2
23 nephrotic syndrome 9.8 ALB NPHS1 NPHS2
24 frasier syndrome 9.8 NPHS1 NPHS2
25 chronic kidney failure 9.8 ALB NPHS1 NPHS2
26 focal segmental glomerulosclerosis 9.8 ALB NPHS1 NPHS2
27 chronic pyelonephritis 9.7
28 pyelonephritis 9.7
29 bronchopneumonia 9.7
30 arteriosclerosis 9.7
31 uremia 9.7
32 end stage renal failure 9.7 ALB FN1 NPHS1 NPHS2
33 kidney disease 9.4 ALB NPHS1 NPHS2

Comorbidity relations with Kidney Hypertrophy via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Kidney Hypertrophy:



Diseases related to Kidney Hypertrophy

Symptoms & Phenotypes for Kidney Hypertrophy

Drugs & Therapeutics for Kidney Hypertrophy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Matrix Metalloproteinases and Diabetic Nephropathy Completed NCT00067886

Search NIH Clinical Center for Kidney Hypertrophy

Genetic Tests for Kidney Hypertrophy

Anatomical Context for Kidney Hypertrophy

MalaCards organs/tissues related to Kidney Hypertrophy:

42
Kidney

Publications for Kidney Hypertrophy

Articles related to Kidney Hypertrophy:

(show all 25)
# Title Authors Year
1
Ureteric entrapment in sacroiliac joint causing hydroureter and ipsilateral kidney hypertrophy. ( 29222673 )
2018
2
Linagliptin unmasks specific antioxidant pathways protective against albuminuria and kidney hypertrophy in a mouse model of diabetes. ( 29979777 )
2018
3
Correlation of whole kidney hypertrophy with glomerular over-filtration in live, gender-mismatched renal transplant allografts. ( 27576505 )
2017
4
Stimulation of Sigma-1 receptor by dehydroepiandrosterone ameliorates hypertension-induced kidney hypertrophy in ovariectomized rats. ( 20404054 )
2010
5
Development of hypertension and kidney hypertrophy in transgenic mice overexpressing ARAP1 gene in the kidney. ( 16801480 )
2006
6
Effect of ammonium chloride and dietary phosphorus in the azotaemic rat. Part II--Kidney hypertrophy and calcium deposition. ( 15161952 )
2004
7
Renin-angiotensin system blockade prevents the increase in plasma transforming growth factor beta 1, and reduces proteinuria and kidney hypertrophy in the streptozotocin-diabetic rat. ( 15526251 )
2004
8
The juvenile three-spined stickleback (Gasterosteus aculeatus L.) as a model organism for endocrine disruption II--kidney hypertrophy, vitellogenin and spiggin induction. ( 15588642 )
2004
9
Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. ( 8603776 )
1996
10
An evaluation of the role of polyamines in different models of kidney hypertrophy in mice. ( 7474658 )
1995
11
Inhibition of renal ornithine decarboxylase activity fails to reduce kidney size and urinary albumin excretion in diabetic rats with manifest kidney hypertrophy. ( 7796931 )
1995
12
Renal proteinases and kidney hypertrophy in experimental diabetes. ( 7926340 )
1994
13
Inhibition of renal ornithine decarboxylase activity prevents kidney hypertrophy in experimental diabetes. ( 8447376 )
1993
14
Transient increase in renal insulin-like growth factor binding proteins during initial kidney hypertrophy in experimental diabetes in rats. ( 1377139 )
1992
15
Morphometric analysis of kidney hypertrophy in rats after chronic potassium depletion. ( 1566879 )
1992
16
Vasopressin-dependent kidney hypertrophy: role of urinary concentration in protein-induced hypertrophy and in the progression of chronic renal failure. ( 2042645 )
1991
17
Characterization of beta-adrenergic receptor subtypes in androgen-induced mouse kidney hypertrophy using a new high-affinity ligand, [125I]iodocyanopindolol. ( 6299377 )
1983
18
Increased beta-adrenergic receptor complement in androgen-induced mouse kidney hypertrophy. ( 6269651 )
1981
19
Regulation of compensatory kidney hypertrophy by its own products. ( 894611 )
1977
20
The influence of salt intake on glomerular count in compensatory kidney hypertrophy in rats of different ages. ( 954972 )
1976
21
Ornithine decarboxylase activity and polyamine synthesis during kidney hypertrophy. ( 4119904 )
1972
22
Immunochemical studies on kidney hypertrophy of the rat. ( 13954727 )
1962
23
WEEKLY clinicopathological exercises: chronic pyelonephritis severe (with uremia); atrophy of the right kidney, hypertrophy of left; bronchopneumonia; aortic arteriosclerosis, severe, ascending arch, with short localized dissection; calcareous aortic stenosis. ( 14863577 )
1951
24
Kidney hypertrophy in B complex deficiency. ( 21024173 )
1946
25
THE PRODUCTION OF HYPERTENSION BY THE PREVENTION OF KIDNEY HYPERTROPHY: (Preliminary Report). ( 20321520 )
1939

Variations for Kidney Hypertrophy

Expression for Kidney Hypertrophy

Search GEO for disease gene expression data for Kidney Hypertrophy.

Pathways for Kidney Hypertrophy

Pathways related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.82 NPHS1 NPHS2
2 10.04 NPHS1 NPHS2

GO Terms for Kidney Hypertrophy

Cellular components related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.96 ALB FN1
2 slit diaphragm GO:0036057 8.62 NPHS1 NPHS2

Biological processes related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 excretion GO:0007588 9.16 NPHS1 NPHS2
2 exogenous drug catabolic process GO:0042738 8.96 CYP2F1 CYP2U1
3 organic acid metabolic process GO:0006082 8.62 CYP2F1 CYP2U1

Molecular functions related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.37 CYP2F1 CYP2U1
2 monooxygenase activity GO:0004497 9.32 CYP2F1 CYP2U1
3 oxygen binding GO:0019825 9.26 ALB CYP2F1
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.16 CYP2F1 CYP2U1
5 steroid hydroxylase activity GO:0008395 8.96 CYP2F1 CYP2U1
6 aromatase activity GO:0070330 8.62 CYP2F1 CYP2U1

Sources for Kidney Hypertrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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