MCID: KDN006
MIFTS: 30

Kidney Papillary Necrosis

Categories: Nephrological diseases

Aliases & Classifications for Kidney Papillary Necrosis

MalaCards integrated aliases for Kidney Papillary Necrosis:

Name: Kidney Papillary Necrosis 12 44 15 73
Necrotizing Renal Papillitis 12
Renal Papillitis Necrotizing 12
Papillary Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2981
MeSH 44 D007681
SNOMED-CT 68 197651008 90241004
UMLS 73 C0022667

Summaries for Kidney Papillary Necrosis

MalaCards based summary : Kidney Papillary Necrosis, also known as necrotizing renal papillitis, is related to anuria and renal tuberculosis. An important gene associated with Kidney Papillary Necrosis is LYZ (Lysozyme), and among its related pathways/superpathways are Celecoxib Pathway, Pharmacodynamics and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The drugs Pharmaceutical Solutions and Heptavalent Pneumococcal Conjugate Vaccine have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 76 Renal papillary necrosis is a form of nephropathy involving the necrosis of the renal papilla. Lesions... more...

Related Diseases for Kidney Papillary Necrosis

Graphical network of the top 20 diseases related to Kidney Papillary Necrosis:



Diseases related to Kidney Papillary Necrosis

Symptoms & Phenotypes for Kidney Papillary Necrosis

MGI Mouse Phenotypes related to Kidney Papillary Necrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 ALB CLU LYZ NFAT5 PTGIR PTGS1
2 cardiovascular system MP:0005385 9.88 CLU LYZ NFAT5 PTGIR PTGS1 REN
3 immune system MP:0005387 9.8 CLU LYZ NFAT5 PTGIR PTGS1 REN
4 mortality/aging MP:0010768 9.73 ALB LYZ NFAT5 PTGIR PTGS1 REN
5 muscle MP:0005369 9.55 REN ALB CLU NFAT5 PTGS1
6 neoplasm MP:0002006 9.26 ALB LYZ PTGIR PTGS1
7 renal/urinary system MP:0005367 9.1 ALB CLU LYZ NFAT5 PTGS1 REN

Drugs & Therapeutics for Kidney Papillary Necrosis

Drugs for Kidney Papillary Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 2
2 Heptavalent Pneumococcal Conjugate Vaccine
3 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of CSL112 in Adults With Moderate Renal Impairment and Acute Myocardial Infarction Completed NCT02742103 Phase 2
2 Regional and Long Term Outcomes of Acute Kidney Injury in England From 2000 to 2015 - A National Database Study Completed NCT02675296
3 Postlicensure Observational Safety Study of 13vPnC Administered to Infants and Toddlers Completed NCT01128426

Search NIH Clinical Center for Kidney Papillary Necrosis

Cochrane evidence based reviews: kidney papillary necrosis

Genetic Tests for Kidney Papillary Necrosis

Anatomical Context for Kidney Papillary Necrosis

MalaCards organs/tissues related to Kidney Papillary Necrosis:

41
Kidney

Publications for Kidney Papillary Necrosis

Articles related to Kidney Papillary Necrosis:

# Title Authors Year
1
Necrotizing renal papillitis review and report of a case treated by nephrectomy and complicated by Waterhouse-Friderichsen syndrome. ( 13512121 )
1958

Variations for Kidney Papillary Necrosis

Expression for Kidney Papillary Necrosis

Search GEO for disease gene expression data for Kidney Papillary Necrosis.

Pathways for Kidney Papillary Necrosis

Pathways related to Kidney Papillary Necrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 PTGIR PTGS1
2 10.86 PTGIR PTGS1
3 10.43 PTGIR PTGS1
4 10.07 PTGIR PTGS1

GO Terms for Kidney Papillary Necrosis

Cellular components related to Kidney Papillary Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.62 ALB CLU

Biological processes related to Kidney Papillary Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.33 LYZ PTGIR PTGS1
2 cellular oxidant detoxification GO:0098869 9.32 ALB PTGS1
3 regulation of blood pressure GO:0008217 9.26 PTGS1 REN
4 antimicrobial humoral response GO:0019730 8.96 CLU LYZ
5 retina homeostasis GO:0001895 8.62 ALB LYZ

Molecular functions related to Kidney Papillary Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.62 ALB CLU

Sources for Kidney Papillary Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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