MCID: KDN006
MIFTS: 37

Kidney Papillary Necrosis

Categories: Nephrological diseases

Aliases & Classifications for Kidney Papillary Necrosis

MalaCards integrated aliases for Kidney Papillary Necrosis:

Name: Kidney Papillary Necrosis 12 45 15 17 74
Necrotizing Renal Papillitis 12
Renal Papillitis Necrotizing 12
Papillary Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2981
MeSH 45 D007681
SNOMED-CT 69 90241004
UMLS 74 C0022667

Summaries for Kidney Papillary Necrosis

MalaCards based summary : Kidney Papillary Necrosis, also known as necrotizing renal papillitis, is related to interstitial nephritis and anuria. An important gene associated with Kidney Papillary Necrosis is PTGIR (Prostaglandin I2 Receptor), and among its related pathways/superpathways are Selenium Micronutrient Network and Angiogenesis (CST). The drugs Pharmaceutical Solutions and Heptavalent Pneumococcal Conjugate Vaccine have been mentioned in the context of this disorder. Affiliated tissues include kidney and cortex, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Renal papillary necrosis is a form of nephropathy involving the necrosis of the renal papilla. Lesions... more...

Related Diseases for Kidney Papillary Necrosis

Diseases related to Kidney Papillary Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 interstitial nephritis 30.1 ALB REN
2 anuria 30.0 ALB REN
3 urinary tract obstruction 29.2 ALB PTGS2 REN
4 optic papillitis 10.6
5 diabetes mellitus 10.4
6 acute endometritis 10.2 PTGIR PTGS2
7 pyelonephritis 10.2
8 benign essential hypertension 10.1 ALB REN
9 aspirin resistance 10.1 PTGS1 PTGS2
10 orthostatic proteinuria 10.1 ALB REN
11 active peptic ulcer disease 10.1 PTGS1 PTGS2
12 hepatorenal syndrome 10.1 ALB REN
13 morphine dependence 10.1 PTGS1 PTGS2
14 renal hypertension 10.1 ALB REN
15 hepatic vascular disease 10.1 ALB REN
16 gastric ulcer 10.0 PTGS1 PTGS2
17 acute kidney failure 10.0 ALB REN
18 dyspepsia 10.0 PTGS1 PTGS2
19 ovarian hyperstimulation syndrome 10.0 ALB REN
20 obstructive nephropathy 10.0 ALB REN
21 obstructive jaundice 10.0 ALB REN
22 iga glomerulonephritis 10.0 ALB REN
23 peptic ulcer perforation 10.0 ALB PTGS2
24 sickle cell anemia 10.0
25 ureteral obstruction 10.0
26 cystitis 10.0
27 pancreatitis 10.0
28 acute pyelonephritis 10.0
29 waterhouse-friderichsen syndrome 10.0
30 stomach disease 10.0 PTGS1 PTGS2
31 angioedema 10.0 PTGS1 PTGS2
32 arteries, anomalies of 10.0 ALB REN
33 esophageal disease 10.0 ALB PTGS2
34 gastroesophageal reflux 10.0 PTGS1 PTGS2
35 eclampsia 10.0 ALB REN
36 glucose metabolism disease 10.0 ALB REN
37 hydronephrosis 9.9
38 urticaria 9.9 PTGS1 PTGS2
39 urinary system disease 9.9 ALB REN
40 antenatal bartter syndrome 9.9 PTGS1 PTGS2 REN
41 acquired metabolic disease 9.9 ALB REN
42 hemoglobinopathy 9.9
43 sickle cell disease 9.9
44 intestinal disease 9.8 ALB PTGS2
45 autoimmune disease of urogenital tract 9.8 ALB LBR
46 chronic kidney failure 9.8 ALB PTGS2 REN
47 hydrops, lactic acidosis, and sideroblastic anemia 9.7 ALB PTGS1 PTGS2
48 gastrointestinal system cancer 9.7 ALB PTGS2
49 proteasome-associated autoinflammatory syndrome 1 9.7 ALB PTGS1 PTGS2
50 danubian endemic familial nephropathy 9.7

Graphical network of the top 20 diseases related to Kidney Papillary Necrosis:



Diseases related to Kidney Papillary Necrosis

Symptoms & Phenotypes for Kidney Papillary Necrosis

GenomeRNAi Phenotypes related to Kidney Papillary Necrosis according to GeneCards Suite gene sharing:

27 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.77 PTGS1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.77 NFAT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.77 PTGS1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.77 LBR
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.77 LBR NFAT5 PTGS1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.77 NFAT5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.77 NFAT5
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.77 PTGS1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.77 NFAT5
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.77 PTGS1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.77 PTGS1
12 Reduced mammosphere formation GR00396-S 8.92 ALB NFAT5 PTGIR PTGS2

MGI Mouse Phenotypes related to Kidney Papillary Necrosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 ALB LBR NFAT5 PTGIR PTGS1 PTGS2
2 cardiovascular system MP:0005385 9.88 NFAT5 PTGIR PTGS1 PTGS2 REN
3 hematopoietic system MP:0005397 9.88 LBR NFAT5 PTGIR PTGS1 PTGS2 REN
4 endocrine/exocrine gland MP:0005379 9.83 ALB LBR NFAT5 PTGS1 PTGS2
5 immune system MP:0005387 9.8 LBR NFAT5 PTGIR PTGS1 PTGS2 REN
6 mortality/aging MP:0010768 9.8 ALB LBR NFAT5 PTGIR PTGS1 PTGS2
7 digestive/alimentary MP:0005381 9.76 ALB LBR PTGS1 PTGS2
8 muscle MP:0005369 9.55 ALB NFAT5 PTGS1 PTGS2 REN
9 neoplasm MP:0002006 9.26 ALB PTGIR PTGS1 PTGS2
10 renal/urinary system MP:0005367 9.1 ALB LBR NFAT5 PTGS1 PTGS2 REN

Drugs & Therapeutics for Kidney Papillary Necrosis

Drugs for Kidney Papillary Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 2
2 Heptavalent Pneumococcal Conjugate Vaccine
3 Immunologic Factors
4 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of CSL112 in Adults With Moderate Renal Impairment and Acute Myocardial Infarction Completed NCT02742103 Phase 2
2 Regional and Long Term Outcomes of Acute Kidney Injury in England From 2000 to 2015 - A National Database Study Completed NCT02675296
3 Postlicensure Observational Safety Study of 13vPnC Administered to Infants and Toddlers Completed NCT01128426

Search NIH Clinical Center for Kidney Papillary Necrosis

Cochrane evidence based reviews: kidney papillary necrosis

Genetic Tests for Kidney Papillary Necrosis

Anatomical Context for Kidney Papillary Necrosis

MalaCards organs/tissues related to Kidney Papillary Necrosis:

42
Kidney, Cortex

Publications for Kidney Papillary Necrosis

Articles related to Kidney Papillary Necrosis:

(show all 17)
# Title Authors Year
1
REVERSIBLE RENAL SHUTDOWN SECONDARY TO NECROTIZING RENAL PAPILLITIS. REPORT OF A CASE ASSOCIATED WITH PHENACETIN ABUSE. ( 14132841 )
1964
2
NECROTIZING RENAL PAPILLITIS (PAPILLARY NECROSIS) IN DIABETES MELLITUS. ( 14251899 )
1964
3
Necrotizing renal papillitis review and report of a case treated by nephrectomy and complicated by Waterhouse-Friderichsen syndrome. ( 13512121 )
1958
4
Papillary calcification in necrotizing renal papillitis. ( 13478793 )
1957
5
The roentgen aspects of necrotizing renal papillitis. ( 13350510 )
1956
6
Necrotizing renal papillitis and diabetes mellitus. ( 13357328 )
1956
7
Pyelographic changes in necrotizing renal papillitis. ( 13163988 )
1954
8
Necrotizing renal papillitis. ( 13031411 )
1953
9
Coronary embolism (intra vitam diagnosis) and necrotizing renal papillitis: case report. ( 14895060 )
1952
10
Acute necrotizing renal papillitis experimentally produced in rats fed mono-N-methylaniline. ( 14908543 )
1952
11
WEEKLY clinicopathological exercises: diabetes mellitus, severe; intercapillary glomerulosclerosis, severe; necrotizing renal papillitis, bilateral; pyelonephritis, bilateral. ( 14827076 )
1951
12
CLINICAL pathologic conference; diabetes mellitus with necrotizing renal papillitis. ( 14898266 )
1951
13
Necrotizing renal papillitis. ( 15395669 )
1949
14
Necrotizing renal papillitis. ( 18136081 )
1949
15
Chronic interstitial pancreatitis with diabetes mellitus and terminal necrotizing renal papillitis. ( 18899324 )
1948
16
Necrotizing renal papillitis; report of a case with cystitis emphysematosa and intercapillary glomerulofibrosis. ( 20255869 )
1947
17
Necrotizing renal papillitis; a form of acute pyelonephritis. ( 20277649 )
1946

Variations for Kidney Papillary Necrosis

Expression for Kidney Papillary Necrosis

Search GEO for disease gene expression data for Kidney Papillary Necrosis.

Pathways for Kidney Papillary Necrosis

GO Terms for Kidney Papillary Necrosis

Biological processes related to Kidney Papillary Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.58 PTGIR PTGS1 PTGS2
2 response to lipopolysaccharide GO:0032496 9.5 PTGIR PTGS2 REN
3 response to organic substance GO:0010033 9.46 PTGS2 REN
4 fatty acid biosynthetic process GO:0006633 9.43 PTGS1 PTGS2
5 prostaglandin metabolic process GO:0006693 9.37 PTGS1 PTGS2
6 prostaglandin biosynthetic process GO:0001516 9.26 PTGS1 PTGS2
7 cyclooxygenase pathway GO:0019371 9.16 PTGS1 PTGS2
8 cellular oxidant detoxification GO:0098869 9.13 ALB PTGS1 PTGS2
9 regulation of blood pressure GO:0008217 8.8 PTGS1 PTGS2 REN

Molecular functions related to Kidney Papillary Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dioxygenase activity GO:0051213 9.16 PTGS1 PTGS2
2 peroxidase activity GO:0004601 8.96 PTGS1 PTGS2
3 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS1 PTGS2

Sources for Kidney Papillary Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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