MCID: KDN006
MIFTS: 31

Kidney Papillary Necrosis

Categories: Nephrological diseases

Aliases & Classifications for Kidney Papillary Necrosis

MalaCards integrated aliases for Kidney Papillary Necrosis:

Name: Kidney Papillary Necrosis 12 44 15 17 70
Necrotizing Renal Papillitis 12
Renal Papillitis Necrotizing 12
Papillary Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2981
MeSH 44 D007681
SNOMED-CT 67 90241004
UMLS 70 C0022667

Summaries for Kidney Papillary Necrosis

MalaCards based summary : Kidney Papillary Necrosis, also known as necrotizing renal papillitis, is related to acute kidney failure and pyuria. An important gene associated with Kidney Papillary Necrosis is REN (Renin), and among its related pathways/superpathways are Selenium Micronutrient Network and Binding and Uptake of Ligands by Scavenger Receptors. Affiliated tissues include kidney, heart and bone marrow, and related phenotypes are muscle and renal/urinary system

Wikipedia : 73 Renal papillary necrosis is a form of nephropathy involving the necrosis of the renal papilla. Lesions... more...

Related Diseases for Kidney Papillary Necrosis

Diseases related to Kidney Papillary Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 230)
# Related Disease Score Top Affiliating Genes
1 acute kidney failure 30.8 REN HAVCR1 ALB
2 pyuria 30.6 HAVCR1 ALB
3 chronic pyelonephritis 30.5 REN ALB ACE
4 hydronephrosis 30.4 REN HAVCR1 AQP2 ALB
5 microvascular complications of diabetes 3 30.4 REN ALB ACE
6 interstitial nephritis 30.3 REN PTGS1 HAVCR1 ALB ACE
7 glomerulonephritis 30.3 APOL1 ALB ACE
8 acute cystitis 30.2 REN HAVCR1 ALB ACE
9 hypertension, diastolic 30.2 REN ACE
10 anuria 30.1 REN HAVCR1 ALB ACE
11 proteinuria, chronic benign 30.0 REN APOL1 ALB ACE
12 uremia 30.0 REN ALB ACE
13 kidney disease 29.8 REN EDN1 AQP2 ALB ACE
14 acute kidney tubular necrosis 29.7 REN OGA HAVCR1 ALB ACE
15 urinary tract obstruction 29.6 REN PTGS2 HAVCR1 AQP2 ALB ACE
16 sickle cell anemia 29.6 HBB EDN1 APOL1 ALB ACE
17 focal segmental glomerulosclerosis 29.5 EDN1 APOL1 ALB ACE
18 nephrotic syndrome 29.5 REN AQP2 APOL1 ALB ACE
19 pyelitis 29.4 REN OGA HAVCR1 ALB ACE
20 migraine with or without aura 1 29.3 REN PTGS2 EDN1 ALB ACE
21 liver cirrhosis 29.3 REN EDN1 AQP2 ALB ACE
22 diabetes mellitus 28.4 REN PTGS2 PTGS1 HBB EDN1 ALB
23 optic papillitis 10.7
24 renal artery obstruction 10.4 REN ACE
25 urinary tract infection 10.4
26 hypoaldosteronism 10.4 REN ACE
27 renal artery atheroma 10.3 REN APOL1
28 cholesterol embolism 10.3 REN ACE
29 glomerular disease 10.3 ALB ACE
30 benign essential hypertension 10.3 REN ALB
31 aneruptive fever 10.3 HBB ALB
32 potter's syndrome 10.3 REN ACE
33 granulomatous hepatitis 10.3 ALB ACE
34 intracranial embolism 10.3 ALB ACE
35 fibromuscular dysplasia 10.3 REN ACE
36 heart aneurysm 10.3 ALB ACE
37 cranial nerve palsy 10.3 ALB ACE
38 hemoglobin d disease 10.3 HBB ALB
39 splenic infarction 10.3 HBB ALB
40 hypertensive nephropathy 10.3 ALB ACE
41 arteriolosclerosis 10.3 REN ALB
42 pure autonomic failure 10.3 REN ACE
43 idiopathic nephrotic syndrome 10.3 ALB ACE
44 pyelonephritis 10.3
45 left bundle branch hemiblock 10.3 REN ACE
46 central sleep apnea 10.3 REN ACE
47 dicrocoeliasis 10.3 PTGS1 ALB
48 central pontine myelinolysis 10.3 AQP2 ALB
49 generalized atherosclerosis 10.2 REN ALB ACE
50 severe nonproliferative diabetic retinopathy 10.2 REN ALB ACE

Graphical network of the top 20 diseases related to Kidney Papillary Necrosis:



Diseases related to Kidney Papillary Necrosis

Symptoms & Phenotypes for Kidney Papillary Necrosis

MGI Mouse Phenotypes related to Kidney Papillary Necrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.43 ALB EDN1 NFAT5 PTGS1 PTGS2 REN
2 renal/urinary system MP:0005367 9.23 ACE ALB AQP2 EDN1 NFAT5 PTGS1

Drugs & Therapeutics for Kidney Papillary Necrosis

Search Clinical Trials , NIH Clinical Center for Kidney Papillary Necrosis

Cochrane evidence based reviews: kidney papillary necrosis

Genetic Tests for Kidney Papillary Necrosis

Anatomical Context for Kidney Papillary Necrosis

MalaCards organs/tissues related to Kidney Papillary Necrosis:

40
Kidney, Heart, Bone Marrow, Bone, Cortex, Liver, Thyroid

Publications for Kidney Papillary Necrosis

Articles related to Kidney Papillary Necrosis:

(show all 14)
# Title Authors PMID Year
1
[Kidney papillary necrosis: experience with 61 cases]. 61
8191157 1993
2
[Kidney papillary necrosis in a 3-month-old infant]. 61
6657338 1983
3
[Kidney papillary necrosis in cystic kidney medulla with atrophy (nephronophthisis)]. 61
7147957 1982
4
[What is your diagnosis? Kidney papillary necrosis in sickle cell anemia]. 61
7099864 1982
5
[Kidney papillary necrosis in childhood]. 61
762920 1979
6
[Kidney papillary necrosis. Clinical pathology of 238 observations]. 61
4448119 1974
7
[Kidney papillary necrosis]. 61
4727130 1973
8
[Kidney papillary necrosis]. 61
4635634 1972
9
[Kidney papillary necrosis in children]. 61
5448453 1970
10
[Kidney papillary necrosis and analgesic abuse]. 61
5820098 1969
11
[On the symptoms and prognosis of kidney papillary necrosis]. 61
5991303 1966
12
[On the diagnosis of kidney papillary necrosis]. 61
5924369 1966
13
[Kidney papillary necrosis in the phenacetin-damaged kidney]. 61
5919204 1966
14
[Kidney papillary necrosis]. 61
5987336 1966

Variations for Kidney Papillary Necrosis

Expression for Kidney Papillary Necrosis

Search GEO for disease gene expression data for Kidney Papillary Necrosis.

Pathways for Kidney Papillary Necrosis

GO Terms for Kidney Papillary Necrosis

Cellular components related to Kidney Papillary Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.8 HBB APOL1 ALB

Biological processes related to Kidney Papillary Necrosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.69 REN PTGS2 EDN1
2 receptor-mediated endocytosis GO:0006898 9.67 HBB APOL1 ALB
3 positive regulation of nitric oxide biosynthetic process GO:0045429 9.5 PTGS2 HBB EDN1
4 regulation of vasoconstriction GO:0019229 9.48 EDN1 ACE
5 positive regulation of smooth muscle contraction GO:0045987 9.46 PTGS2 EDN1
6 amyloid-beta metabolic process GO:0050435 9.43 REN ACE
7 angiotensin maturation GO:0002003 9.4 REN ACE
8 cyclooxygenase pathway GO:0019371 9.37 PTGS2 PTGS1
9 prostaglandin biosynthetic process GO:0001516 9.33 PTGS2 PTGS1 EDN1
10 nitric oxide transport GO:0030185 9.26 HBB EDN1
11 cellular oxidant detoxification GO:0098869 9.26 PTGS2 PTGS1 HBB ALB
12 regulation of blood pressure GO:0008217 9.1 REN PTGS2 PTGS1 HBB EDN1 ACE

Molecular functions related to Kidney Papillary Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.33 PTGS2 PTGS1 HBB
2 peroxidase activity GO:0004601 9.13 PTGS2 PTGS1 HBB
3 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS2 PTGS1

Sources for Kidney Papillary Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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