MCID: KDN006
MIFTS: 31

Kidney Papillary Necrosis

Categories: Nephrological diseases

Aliases & Classifications for Kidney Papillary Necrosis

MalaCards integrated aliases for Kidney Papillary Necrosis:

Name: Kidney Papillary Necrosis 12 44 15 73
Necrotizing Renal Papillitis 12
Renal Papillitis Necrotizing 12
Papillary Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2981
MeSH 44 D007681
SNOMED-CT 68 90241004
UMLS 73 C0022667

Summaries for Kidney Papillary Necrosis

MalaCards based summary : Kidney Papillary Necrosis, also known as necrotizing renal papillitis, is related to anuria and interstitial nephritis. An important gene associated with Kidney Papillary Necrosis is LYZ (Lysozyme), and among its related pathways/superpathways are Platelet activation and Celecoxib Pathway, Pharmacodynamics. The drugs Pharmaceutical Solutions and Heptavalent Pneumococcal Conjugate Vaccine have been mentioned in the context of this disorder. Affiliated tissues include kidney and cortex, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 76 Renal papillary necrosis is a form of nephropathy involving the necrosis of the renal papilla. Lesions... more...

Related Diseases for Kidney Papillary Necrosis

Diseases related to Kidney Papillary Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 anuria 29.9 ALB REN
2 interstitial nephritis 29.8 ALB REN
3 pyelitis 29.6 LYZ REN
4 urinary tract obstruction 29.5 ALB REN
5 optic papillitis 10.6
6 diabetes mellitus 10.3
7 pyelonephritis 10.1
8 diffuse glomerulonephritis 10.1 ALB LYZ
9 ulcerative stomatitis 10.1 ALB LYZ
10 renal tuberculosis 10.1 LYZ REN
11 benign essential hypertension 10.0 ALB REN
12 orthostatic proteinuria 10.0 ALB REN
13 hepatorenal syndrome 10.0 ALB REN
14 renal hypertension 10.0 ALB REN
15 hepatic vascular disease 10.0 ALB REN
16 acute kidney failure 10.0 ALB REN
17 ovarian hyperstimulation syndrome 10.0 ALB REN
18 obstructive nephropathy 10.0 ALB REN
19 obstructive jaundice 10.0 ALB REN
20 iga glomerulonephritis 10.0 ALB REN
21 cystitis 10.0
22 pancreatitis 10.0
23 acute pyelonephritis 10.0
24 waterhouse-friderichsen syndrome 10.0
25 arteries, anomalies of 10.0 ALB REN
26 meningitis 10.0 ALB LYZ
27 eclampsia 10.0 ALB REN
28 glucose metabolism disease 10.0 ALB REN
29 sickle cell anemia 9.9
30 ureteral obstruction 9.9
31 hydrops, lactic acidosis, and sideroblastic anemia 9.9 ALB PTGS1
32 antenatal bartter syndrome 9.9 PTGS1 REN
33 acquired metabolic disease 9.9 ALB REN
34 urinary system disease 9.9 ALB LYZ REN
35 medullary sponge kidney 9.8
36 hydronephrosis 9.8
37 hemoglobinopathy 9.8
38 proteasome-associated autoinflammatory syndrome 1 9.8 ALB PTGS1
39 autosomal dominant polycystic kidney disease 9.8 ALB REN
40 danubian endemic familial nephropathy 9.7
41 focal segmental glomerulosclerosis 1 9.7
42 focal segmental glomerulosclerosis 9.7
43 glomerulonephritis 9.7
44 chronic pyelonephritis 9.7
45 acute cystitis 9.7
46 histoplasmosis 9.7
47 leptospirosis 9.7
48 gastroenteritis 9.7
49 kidney cortex necrosis 9.7
50 protein c deficiency 9.7

Graphical network of the top 20 diseases related to Kidney Papillary Necrosis:



Diseases related to Kidney Papillary Necrosis

Symptoms & Phenotypes for Kidney Papillary Necrosis

MGI Mouse Phenotypes related to Kidney Papillary Necrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.85 ALB LYZ NFAT5 PTGIR PTGS1 REN
2 cardiovascular system MP:0005385 9.83 LYZ NFAT5 PTGIR PTGS1 REN
3 hematopoietic system MP:0005397 9.8 LYZ NFAT5 PTGIR PTGS1 REN
4 mortality/aging MP:0010768 9.73 ALB LYZ NFAT5 PTGIR PTGS1 REN
5 immune system MP:0005387 9.72 LYZ NFAT5 PTGIR PTGS1 REN
6 muscle MP:0005369 9.46 ALB NFAT5 PTGS1 REN
7 neoplasm MP:0002006 9.26 ALB LYZ PTGIR PTGS1
8 renal/urinary system MP:0005367 9.02 ALB LYZ NFAT5 PTGS1 REN

Drugs & Therapeutics for Kidney Papillary Necrosis

Drugs for Kidney Papillary Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 2
2 Heptavalent Pneumococcal Conjugate Vaccine
3 Vaccines
4 Immunologic Factors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of CSL112 in Adults With Moderate Renal Impairment and Acute Myocardial Infarction Completed NCT02742103 Phase 2
2 Regional and Long Term Outcomes of Acute Kidney Injury in England From 2000 to 2015 - A National Database Study Completed NCT02675296
3 Postlicensure Observational Safety Study of 13vPnC Administered to Infants and Toddlers Completed NCT01128426

Search NIH Clinical Center for Kidney Papillary Necrosis

Cochrane evidence based reviews: kidney papillary necrosis

Genetic Tests for Kidney Papillary Necrosis

Anatomical Context for Kidney Papillary Necrosis

MalaCards organs/tissues related to Kidney Papillary Necrosis:

41
Kidney, Cortex

Publications for Kidney Papillary Necrosis

Articles related to Kidney Papillary Necrosis:

(show all 17)
# Title Authors Year
1
REVERSIBLE RENAL SHUTDOWN SECONDARY TO NECROTIZING RENAL PAPILLITIS. REPORT OF A CASE ASSOCIATED WITH PHENACETIN ABUSE. ( 14132841 )
1964
2
NECROTIZING RENAL PAPILLITIS (PAPILLARY NECROSIS) IN DIABETES MELLITUS. ( 14251899 )
1964
3
Necrotizing renal papillitis review and report of a case treated by nephrectomy and complicated by Waterhouse-Friderichsen syndrome. ( 13512121 )
1958
4
Papillary calcification in necrotizing renal papillitis. ( 13478793 )
1957
5
The roentgen aspects of necrotizing renal papillitis. ( 13350510 )
1956
6
Necrotizing renal papillitis and diabetes mellitus. ( 13357328 )
1956
7
Pyelographic changes in necrotizing renal papillitis. ( 13163988 )
1954
8
Necrotizing renal papillitis. ( 13031411 )
1953
9
Coronary embolism (intra vitam diagnosis) and necrotizing renal papillitis: case report. ( 14895060 )
1952
10
Acute necrotizing renal papillitis experimentally produced in rats fed mono-N-methylaniline. ( 14908543 )
1952
11
WEEKLY clinicopathological exercises: diabetes mellitus, severe; intercapillary glomerulosclerosis, severe; necrotizing renal papillitis, bilateral; pyelonephritis, bilateral. ( 14827076 )
1951
12
CLINICAL pathologic conference; diabetes mellitus with necrotizing renal papillitis. ( 14898266 )
1951
13
Necrotizing renal papillitis. ( 15395669 )
1949
14
Necrotizing renal papillitis. ( 18136081 )
1949
15
Chronic interstitial pancreatitis with diabetes mellitus and terminal necrotizing renal papillitis. ( 18899324 )
1948
16
Necrotizing renal papillitis; report of a case with cystitis emphysematosa and intercapillary glomerulofibrosis. ( 20255869 )
1947
17
Necrotizing renal papillitis; a form of acute pyelonephritis. ( 20277649 )
1946

Variations for Kidney Papillary Necrosis

Expression for Kidney Papillary Necrosis

Search GEO for disease gene expression data for Kidney Papillary Necrosis.

Pathways for Kidney Papillary Necrosis

Pathways related to Kidney Papillary Necrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.41 PTGIR PTGS1
2 11.02 PTGIR PTGS1
3 10.86 PTGIR PTGS1
4 10.43 PTGIR PTGS1
5 10.07 PTGIR PTGS1

GO Terms for Kidney Papillary Necrosis

Biological processes related to Kidney Papillary Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.26 ALB PTGS1
2 regulation of blood pressure GO:0008217 9.16 PTGS1 REN
3 inflammatory response GO:0006954 9.13 LYZ PTGIR PTGS1
4 retina homeostasis GO:0001895 8.62 ALB LYZ

Sources for Kidney Papillary Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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