MCID: KDN002
MIFTS: 33

Kidney Rhabdoid Cancer

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Kidney Rhabdoid Cancer

MalaCards integrated aliases for Kidney Rhabdoid Cancer:

Name: Kidney Rhabdoid Cancer 12 15
Rhabdoid Tumor of the Kidney 17 74
Kidney Rhabdoid Tumor 12
Renal Rhabdoid Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3674
NCIt 51 C8715
UMLS 74 C0854917

Summaries for Kidney Rhabdoid Cancer

Disease Ontology : 12 A embryonal cancer that is located in the kidney.

MalaCards based summary : Kidney Rhabdoid Cancer, also known as rhabdoid tumor of the kidney, is related to rhabdoid cancer and proliferative fasciitis. An important gene associated with Kidney Rhabdoid Cancer is SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1). The drugs Vincristine and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include kidney and brain.

Related Diseases for Kidney Rhabdoid Cancer

Diseases related to Kidney Rhabdoid Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 rhabdoid cancer 29.3 ENO2 EWSR1 MB SMARCB1 WT1
2 proliferative fasciitis 10.3 MB SMARCB1
3 synovium cancer 10.3 EWSR1 SMARCB1
4 mesenchymal cell neoplasm 10.3 EWSR1 SMARCB1
5 sarcomatosis 10.3 EWSR1 WT1
6 kidney sarcoma 10.3 MB WT1
7 spindle cell liposarcoma 10.3 SMARCB1 WT1
8 renal adenoma 10.2 B3GAT1 WT1
9 adult fibrosarcoma 10.2 MB WT1
10 epithelial predominant wilms' tumor 10.2 B3GAT1 WT1
11 large cell carcinoma with rhabdoid phenotype 10.2 ENO2 SMARCB1
12 spindle cell synovial sarcoma 10.2 MB SMARCB1
13 melanotic medulloblastoma 10.2 ENO2 SMARCB1
14 bladder sarcoma 10.2 CD99 EWSR1
15 epithelioid malignant peripheral nerve sheath tumor 10.2 ENO2 SMARCB1
16 small cell osteogenic sarcoma 10.2 ENO2 EWSR1
17 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.2 B3GAT1 PTPRC
18 hodgkin's lymphoma, mixed cellularity 10.2 B3GAT1 PTPRC
19 kidney benign neoplasm 10.2 B3GAT1 WT1
20 askin's tumor 10.2 ENO2 EWSR1
21 cerebral ventricle cancer 10.2 ENO2 SMARCB1
22 orbital cancer 10.2 ENO2 MB
23 epithelioid sarcoma 10.2 MB SMARCB1
24 thymus lipoma 10.2 MB PTPRC
25 immune system organ benign neoplasm 10.2 MB PTPRC
26 plexiform schwannoma 10.2 B3GAT1 ENO2
27 angiomyoma 10.2 ENO2 MB
28 small cell carcinoma 10.2 ENO2 PTPRC
29 chondroid chordoma 10.2 ENO2 SMARCB1
30 cerebellar liponeurocytoma 10.1 ENO2 SMARCB1
31 nephrogenic adenofibroma 10.1 B3GAT1 WT1
32 primitive neuroectodermal tumor of the cervix uteri 10.1 ENO2 PTPRC
33 epithelioid cell melanoma 10.1 ENO2 WT1
34 conventional fibrosarcoma 10.1 ENO2 PTPRC
35 endometrial small cell carcinoma 10.1 ENO2 PTPRC
36 mixed cell type cancer 10.1 ENO2 MB
37 heart sarcoma 10.1 ENO2 WT1
38 vulvar sarcoma 10.1 EWSR1 PTPRC SMARCB1
39 uterine sarcoma 10.1 MB SMARCB1 WT1
40 intracranial primitive neuroectodermal tumor 10.1 CD99 ENO2
41 embryonal rhabdomyosarcoma 10.1 EWSR1 MB
42 ewing's family of tumors 10.1
43 malignant mesenchymoma 10.1 EWSR1 MB WT1
44 myoepithelioma 10.1 EWSR1 PTPRC SMARCB1
45 extraosseous chondrosarcoma 10.1 ENO2 EWSR1 SMARCB1
46 histiocytoma 10.1 EWSR1 MB PTPRC
47 ganglioglioma 10.1 ENO2 SMARCB1
48 cloacogenic carcinoma 10.1 ENO2 PTPRC
49 breast adenomyoepithelioma 10.1 CD99 ENO2
50 acute mountain sickness 10.0 ENO2 MB

Graphical network of the top 20 diseases related to Kidney Rhabdoid Cancer:



Diseases related to Kidney Rhabdoid Cancer

Symptoms & Phenotypes for Kidney Rhabdoid Cancer

Drugs & Therapeutics for Kidney Rhabdoid Cancer

Drugs for Kidney Rhabdoid Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
2
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 38904 10339178 498142
3
Lenograstim Approved, Investigational Phase 3,Phase 1 135968-09-1
4
Sulfamethoxazole Approved Phase 3 723-46-6 5329
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
6
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
7
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
8
Sargramostim Approved, Investigational Phase 3,Phase 1 123774-72-1, 83869-56-1
9
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
10
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 457193 2019
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
12
Doxil Approved June 1999 Phase 3,Phase 2 31703
13 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
14 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
15 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
16 Etoposide phosphate Phase 3,Phase 2,Phase 1
17 Anti-Infective Agents Phase 3,Phase 2,Phase 1
18 Adjuvants, Immunologic Phase 3,Phase 1
19 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
20 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
21 Immunologic Factors Phase 3,Phase 2,Phase 1
22 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
23 Alkylating Agents Phase 3,Phase 2,Phase 1
24 Antibiotics, Antitubercular Phase 3,Phase 2
25 Antimitotic Agents Phase 3,Phase 2,Phase 1,Not Applicable
26 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
27 Antirheumatic Agents Phase 3,Phase 2
28 Cola Phase 3,Phase 1,Phase 2,Not Applicable
29 Central Nervous System Depressants Phase 3
30 Peripheral Nervous System Agents Phase 3
31 Analgesics, Opioid Phase 3
32 Anesthetics Phase 3
33 Anesthetics, Intravenous Phase 3
34 Narcotics Phase 3
35 Analgesics Phase 3
36 Liver Extracts Phase 3,Phase 1,Phase 2,Not Applicable
37 Adjuvants, Anesthesia Phase 3
38 Anesthetics, General Phase 3
39
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
40
Docetaxel Approved, Investigational Phase 1, Phase 2 114977-28-5 148124
41
Mechlorethamine Approved, Investigational Phase 1, Phase 2 51-75-2 4033
42
Ifosfamide Approved Phase 1, Phase 2 3778-73-2 3690
43
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
44
Oblimersen Experimental, Investigational Phase 1, Phase 2 190977-41-4
45 topoisomerase I inhibitors Phase 2
46 Androgens Phase 1, Phase 2
47 lysine Phase 2,Phase 1
48 Protein Kinase Inhibitors Phase 1, Phase 2
49
Isophosphamide mustard Phase 1, Phase 2 0
50
Thiotepa Approved, Investigational Phase 1 52-24-4 5453

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors Completed NCT00002610 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;vincristine sulfate
2 Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor Completed NCT00945009 Phase 3 Doxorubicin Hydrochloride;Vincristine Sulfate
3 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
4 Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors Completed NCT00335556 Phase 2 Doxorubicin Hydrochloride;Irinotecan Hydrochloride;Cyclophosphamide;Etoposide;Carboplatin;Vincristine Sulfate
5 Chemotherapy in Treating Patients With Solid Tumors Completed NCT00003103 Phase 1, Phase 2 docetaxel
6 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2 Tazemetostat
7 Tazemetostat Rollover Study (TRuST): An Open-Label Rollover Study Recruiting NCT02875548 Phase 2 Tazemetostat
8 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
9 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
10 A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma Recruiting NCT02601937 Phase 1 Tazemetostat
11 MT2004-30: Tomotherapy for Solid Tumors Terminated NCT00623077 Phase 1 busulfan;etoposide;ifosfamide;melphalan;thiotepa;Mesna
12 Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom Unknown status NCT00757614
13 Studying Biomarkers in Samples From Young Patients With Rhabdoid Tumors Completed NCT01544569
14 Studying Gene Expression in Samples From Patients With Rhabdoid Tumors Completed NCT01553175
15 Biomarkers in Tissue Samples From Patients With High-Risk Wilms Tumor Completed NCT01118078
16 Collecting and Storing Tissue From Young Patients With Cancer Completed NCT00898755
17 Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients Completed NCT00253383 Not Applicable
18 Study of Kidney Tumors in Younger Patients Recruiting NCT00898365
19 Biomarker Study in Samples From Patients With Malignant Rhabdoid Tumor of the Kidney or Atypical Teratoid Rhabdoid Tumor Withdrawn NCT01453465
20 Studying Biomarkers in Samples From Younger Patients With Kidney Cancer Withdrawn NCT01642095
21 Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Advanced or Refractory Solid Tumors Withdrawn NCT00499291 Not Applicable paclitaxel albumin-stabilized nanoparticle formulation

Search NIH Clinical Center for Kidney Rhabdoid Cancer

Genetic Tests for Kidney Rhabdoid Cancer

Anatomical Context for Kidney Rhabdoid Cancer

MalaCards organs/tissues related to Kidney Rhabdoid Cancer:

42
Kidney, Brain

Publications for Kidney Rhabdoid Cancer

Articles related to Kidney Rhabdoid Cancer:

(show top 50) (show all 62)
# Title Authors Year
1
High-dose treatment for malignant rhabdoid tumor of the kidney: No evidence for improved survival-The Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH) experience. ( 28843054 )
2018
2
Synchronous Central Nervous System Atypical Teratoid/ Rhabdoid Tumor and Malignant Rhabdoid Tumor of the Kidney: Case report of a Long-Term Survivor and Review of the Literature. ( 29223518 )
2017
3
Malignant rhabdoid tumor of the kidney: significantly improved response to pre-operative treatment intensified with doxorubicin. ( 25242089 )
2014
4
Malignant rhabdoid tumor of the kidney arising in an adult patient. ( 24982576 )
2014
5
Malignant rhabdoid tumor of the kidney and spine in an infant. ( 24570822 )
2014
6
Long-term survivor of relapsed stage IV malignant rhabdoid tumor of the kidney. ( 23679167 )
2013
7
Malignant rhabdoid tumor of the kidney combined with multicystic dysplasia in a 5-year-old child. ( 20436719 )
2010
8
Long-term survival after autologous peripheral blood stem cell transplantation in two patients with malignant rhabdoid tumor of the kidney. ( 19260106 )
2009
9
Chylous ascites after nephrectomy without lymphadenectomy for malignant rhabdoid tumor of the kidney: A rare occurrence and literature review. ( 20419024 )
2009
10
Identification and metastatic potential of tumor-initiating cells in malignant rhabdoid tumor of the kidney. ( 19383826 )
2009
11
Rhabdoid tumor of the kidney with spontaneous rupture: case report and review of literature. ( 17492291 )
2008
12
Rhabdoid tumor of the kidney presenting with hemiplegia: report of a case. ( 17454778 )
2007
13
Radiology-Pathology Conference: rhabdoid tumor of the kidney. ( 16500545 )
2006
14
Establishment and characterization of a new cell line, FRTK-1, derived from human malignant rhabdoid tumor of the kidney, with overexpression of epidermal growth factor receptor and cyclooxygenase-2. ( 16820901 )
2006
15
Treatment of stage IV malignant rhabdoid tumor of the kidney (MRTK) with ICE and VDCy: a case report. ( 16772877 )
2006
16
Molecular genetic alterations and gene expression profile of a malignant rhabdoid tumor of the kidney. ( 16337855 )
2005
17
Rhabdoid tumor of the kidney in the National Wilms' Tumor Study: age at diagnosis as a prognostic factor. ( 16234525 )
2005
18
Novel rearrangement of chromosome band 22q11.2 causing 22q11 microdeletion syndrome-like phenotype and rhabdoid tumor of the kidney. ( 15957176 )
2005
19
Prenatal sonographic features of a rhabdoid tumor of the kidney. ( 15065195 )
2004
20
Malignant rhabdoid tumor of the kidney in a child: report of a case with recurrence in the contralateral kidney. ( 15581170 )
2004
21
Cytologic profile of rhabdoid tumor of the kidney. A report of 3 cases. ( 14674079 )
2003
22
Malignant rhabdoid tumor of the kidney in an adult: a case report and review of the literature. ( 12946214 )
2003
23
Concordant rhabdoid tumor of the kidney in a set of identical twins with discordant outcomes. ( 12794530 )
2003
24
Neuroblastoma mimicking rhabdoid tumor of the kidney. ( 12847328 )
2003
25
Treatment of metastatic rhabdoid tumor of the kidney. ( 12142788 )
2002
26
Rhabdoid tumor of the kidney is a component of the rhabdoid predisposition syndrome. ( 12016529 )
2002
27
Establishment and characterization of malignant rhabdoid tumor of the kidney. ( 11115567 )
2001
28
A malignant rhabdoid tumor of the kidney occurring concurrently with a brain tumor: report of a case. ( 10752788 )
2000
29
Successful treatment of a patient with stage IV rhabdoid tumor of the kidney: case report and review. ( 10029814 )
1999
30
[Rhabdoid tumor of the kidney arising in a newborn infant: description of a case with ultrastructural observations]. ( 10536466 )
1999
31
Rhabdoid tumor of the kidney with primitive neuroectodermal tumor of the central nervous system. ( 9881255 )
1998
32
Rhabdoid tumor of the kidney associated with a tumor of the posterior fossa. ( 9477277 )
1998
33
Special imaging casebook. Neonatal malignant rhabdoid tumor of the kidney. ( 9766422 )
1998
34
Pathological case of the month. Rhabdoid tumor of the kidney. ( 9193254 )
1997
35
Rhabdoid tumor of the kidney in children: a comparative study of 21 cases. ( 9016225 )
1997
36
Rhabdoid tumor of the kidney: a report of two cases with respective tumor markers and a specific chromosomal abnormality, del(11p13). ( 8699995 )
1996
37
Rhabdoid tumor of the kidney in an adult: review of the literature and report of a case responding to interleukin-2. ( 8547962 )
1995
38
Rhabdoid tumor of the kidney with humoral hypercalcemia and parathyroid hormone-related protein production. ( 7990762 )
1995
39
Rhabdoid tumor of the kidney with primitive neuroectodermal tumor of the central nervous system: associated tumors with different histologic, cytogenetic, and molecular findings. ( 7530483 )
1994
40
Malignant rhabdoid tumor of the kidney: involvement of chromosome 22. ( 7519873 )
1994
41
Malignant rhabdoid tumor of the kidney expresses insulin-like growth factor II transcripts. ( 8090584 )
1994
42
The G401 cell line, utilized for studies of chromosomal changes in Wilms' tumor, is derived from a rhabdoid tumor of the kidney. ( 8382007 )
1993
43
Medulloblastoma associated with malignant rhabdoid tumor of the kidney: case report. ( 8220786 )
1993
44
Radiologic features of rhabdoid tumor of the kidney. ( 1563429 )
1992
45
Fine-needle aspiration biopsy diagnosis of malignant rhabdoid tumor of the kidney. ( 2026082 )
1991
46
Clinical and imaging features of rhabdoid tumor of the kidney. ( 1897075 )
1991
47
Malignant rhabdoid tumor of the kidney presenting as intraocular metastasis. ( 1851430 )
1991
48
Malignant rhabdoid tumor of the kidney--a case report. ( 1668958 )
1991
49
Malignant rhabdoid tumor of the kidney diagnosed by fine-needle aspiration cytology. ( 2159866 )
1990
50
Malignant rhabdoid tumor of the kidney in an adult. ( 2152948 )
1990

Variations for Kidney Rhabdoid Cancer

Expression for Kidney Rhabdoid Cancer

Search GEO for disease gene expression data for Kidney Rhabdoid Cancer.

Pathways for Kidney Rhabdoid Cancer

GO Terms for Kidney Rhabdoid Cancer

Molecular functions related to Kidney Rhabdoid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 AU-rich element binding GO:0017091 8.62 ELAVL3 ELAVL4

Sources for Kidney Rhabdoid Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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