MCID: KDN002
MIFTS: 37

Kidney Rhabdoid Cancer

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Kidney Rhabdoid Cancer

MalaCards integrated aliases for Kidney Rhabdoid Cancer:

Name: Kidney Rhabdoid Cancer 12 15
Rhabdoid Tumor of the Kidney 17 70
Kidney Rhabdoid Tumor 12
Renal Rhabdoid Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3674
NCIt 50 C8715
UMLS 70 C0854917

Summaries for Kidney Rhabdoid Cancer

Disease Ontology : 12 A embryonal cancer that is located in the kidney.

MalaCards based summary : Kidney Rhabdoid Cancer, also known as rhabdoid tumor of the kidney, is related to monosomy 22 and sarcoma, synovial. An important gene associated with Kidney Rhabdoid Cancer is SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1), and among its related pathways/superpathways are Gastric cancer and Chromatin Regulation / Acetylation. The drugs Vincristine and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and prostate, and related phenotypes are cellular and pigmentation

Related Diseases for Kidney Rhabdoid Cancer

Diseases related to Kidney Rhabdoid Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 206)
# Related Disease Score Top Affiliating Genes
1 monosomy 22 30.5 SMARCB1 CLDN6
2 sarcoma, synovial 30.0 SMARCB1 EWSR1 CCNB3
3 myxoid chondrosarcoma 29.9 SYP SMARCB1 EWSR1
4 cerebellar medulloblastoma 29.8 SYP ENO2
5 central epithelioid sarcoma 29.8 SYP SMARCB1 MB
6 choroid plexus cancer 29.7 SYP SMARCB1 SMARCA4 CLDN6
7 teratoma 29.5 SYP SMARCB1 ENO2
8 rhabdoid cancer 29.3 SYP SMARCC2 SMARCC1 SMARCB1 SMARCA4 EWSR1
9 desmoplastic small round cell tumor 29.3 SYP EWSR1 ENO2 CCNB3
10 rhabdomyosarcoma 28.9 SYP SMARCB1 SMARCA4 MB EWSR1 ENO2
11 clear cell sarcoma 28.9 YWHAE SYP NUTM2B EWSR1 ENO2 CCNB3
12 atypical teratoid rhabdoid tumor 28.8 SYP SMARCC2 SMARCC1 SMARCB1 SMARCA4 EWSR1
13 smarca4-deficient sarcoma of thorax 10.3 SMARCB1 SMARCA4
14 vulvar sarcoma 10.3 SMARCB1 EWSR1
15 juvenile type testicular granulosa cell tumor 10.3 SMARCB1 SMARCA4
16 testicular granulosa cell tumor 10.3 SMARCB1 SMARCA4
17 sweat gland benign neoplasm 10.2 SMARCB1 EWSR1
18 small cell sarcoma 10.2 EWSR1 CCNB3
19 kidney cortex disease 10.2 NUTM2B CCNB3
20 wilms tumor 1 10.2
21 rare tumor 10.2
22 myoepithelial carcinoma 10.2 SMARCB1 EWSR1
23 laryngeal neuroendocrine tumor 10.2 SYP SMARCB1
24 pediatric fibrosarcoma 10.2 EWSR1 CCNB3
25 nodular medulloblastoma 10.1 SYP SMARCB1
26 conventional central osteosarcoma 10.1 EWSR1 CCNB3
27 hypertrichosis 10.1 SMARCC2 SMARCB1 SMARCA4
28 keratinizing squamous cell carcinoma 10.1 SYP SMARCB1
29 orbit rhabdomyosarcoma 10.1 MB EWSR1
30 clear cell meningioma 10.1 SYP SMARCB1
31 synovium cancer 10.1 SMARCB1 EWSR1 CCNB3
32 supratentorial primitive neuroectodermal tumor 10.1 SYP SMARCB1
33 medulloepithelioma 10.1 SYP SMARCB1
34 large cell carcinoma with rhabdoid phenotype 10.1 SMARCB1 ENO2
35 epithelioid cell synovial sarcoma 10.1 SYP EWSR1
36 aniridia 1 10.1
37 renal cell carcinoma, nonpapillary 10.1
38 retinoblastoma 10.1
39 ascites, chylous 10.1
40 nephroma 10.1
41 hemiplegia 10.1
42 kidney cancer 10.1
43 iga glomerulonephritis 10.1
44 paraplegia 10.1
45 polyhydramnios 10.1
46 embryonal sarcoma 10.1
47 multicystic dysplastic kidney 10.1
48 rare renal tumor 10.1
49 pleomorphic xanthoastrocytoma 10.0 SYP SMARCB1
50 plexiform schwannoma 10.0 SMARCB1 ENO2

Graphical network of the top 20 diseases related to Kidney Rhabdoid Cancer:



Diseases related to Kidney Rhabdoid Cancer

Symptoms & Phenotypes for Kidney Rhabdoid Cancer

MGI Mouse Phenotypes related to Kidney Rhabdoid Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.56 CCNB3 ENO2 MB SMARCA4 SMARCB1 SMARCC1
2 pigmentation MP:0001186 8.92 CLDN6 SMARCA4 SMARCC1 YWHAE

Drugs & Therapeutics for Kidney Rhabdoid Cancer

Drugs for Kidney Rhabdoid Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
2
Sulfamethoxazole Approved Phase 3 723-46-6 5329
3
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
4
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
5
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
6
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
8 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
9 Cola Phase 3
10 Liver Extracts Phase 3
11 Antimitotic Agents Phase 3
12 Tubulin Modulators Phase 3
13 Anti-Infective Agents Phase 3
14 Anti-Bacterial Agents Phase 3
15 Antibiotics, Antitubercular Phase 3
16
Liposomal doxorubicin Phase 3 31703
17 Adjuvants, Immunologic Phase 3
18 Antirheumatic Agents Phase 3
19 Anesthetics Phase 3
20 Narcotics Phase 3
21 Analgesics, Opioid Phase 3
22 Analgesics Phase 3
23 Anesthetics, Intravenous Phase 3
24 Anesthetics, General Phase 3
25
Docetaxel Approved, Investigational Phase 1, Phase 2 114977-28-5 148124
26
Etoposide Approved Phase 1, Phase 2 33419-42-0 36462
27
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
28
Ifosfamide Approved Phase 1, Phase 2 3778-73-2 3690
29
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
30
Oblimersen Experimental, Investigational Phase 1, Phase 2 190977-41-4
31 Androgens Phase 1, Phase 2
32 Etoposide phosphate Phase 1, Phase 2
33 Alkylating Agents Phase 1, Phase 2
34
Isophosphamide mustard Phase 1, Phase 2 100427
35 Protein Kinase Inhibitors Phase 1, Phase 2
36
Thalidomide Approved, Investigational, Withdrawn Phase 1 50-35-1 5426
37
Sargramostim Approved, Investigational Phase 1 123774-72-1, 83869-56-1
38
Lenograstim Approved, Investigational Phase 1 135968-09-1
39
Mesna Approved, Investigational Phase 1 3375-50-6 598
40
Melphalan Approved Phase 1 148-82-3 4053 460612
41
Thiotepa Approved, Investigational Phase 1 52-24-4 5453
42
Busulfan Approved, Investigational Phase 1 55-98-1 2478
43
Molgramostim Investigational Phase 1 99283-10-0
44 Angiogenesis Inhibitors Phase 1
45 Immunosuppressive Agents Phase 1
46 Immunologic Factors Phase 1
47 Protective Agents Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 National Wilms Tumor Study-5 -- Treatment of Relapsed Patients, A National Wilms Tumor Study Group Phase III Study Completed NCT00002610 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;vincristine sulfate
2 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 A Phase I/IIA Dose-Escalating Trial of BCL-2 Antisense (G3139) Treatment for Patients With Androgen-Independent Prostate Cancer or Other Advanced Solid Tumor Malignancies Completed NCT00003103 Phase 1, Phase 2 docetaxel
4 Dasatinib With Ifosfamide, Carboplatin, Etoposide: A Pediatric Phase I/II Trial Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
5 Phase I Pharmacokinetic Trial of Thalidomide and Docetaxel: A Regimen Based on Anti-Angiogenic Therapeutic Principles Completed NCT00049296 Phase 1 docetaxel;thalidomide
6 Dose Escalation of Total Marrow Irradiation Added to an Alkylator-Intense Conditioning Regimen for Patients With High Risk or Relapsed Solid Tumors Terminated NCT00623077 Phase 1 busulfan;etoposide;ifosfamide;melphalan;thiotepa;Mesna
7 A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Cancer in East Anglia, Trent and West Midlands Unknown status NCT00757614
8 Improving Palliative Care for Patients With Cancer Completed NCT00253383
9 Endogenous DNA Transposition in Rhabdoid Tumors Completed NCT01544569
10 Determination of the Frequency of BRG1 and BRM Loss in Rhabdoid Tumors Completed NCT01553175
11 Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Study of Nab-Paclitaxel (Nanoparticle Albumin Bound-Paclitaxel) in Patients With Advanced Solid Tumors Withdrawn NCT00499291 paclitaxel albumin-stabilized nanoparticle formulation

Search NIH Clinical Center for Kidney Rhabdoid Cancer

Genetic Tests for Kidney Rhabdoid Cancer

Anatomical Context for Kidney Rhabdoid Cancer

MalaCards organs/tissues related to Kidney Rhabdoid Cancer:

40
Kidney, Liver, Prostate, Pancreas

Publications for Kidney Rhabdoid Cancer

Articles related to Kidney Rhabdoid Cancer:

(show top 50) (show all 142)
# Title Authors PMID Year
1
Malignant rhabdoid tumor of the kidney in an adult with loss of INI1 expression and mutation in the SMARCB1 gene. 61
33677955 2021
2
Rhabdoid tumor predisposition syndrome with renal tumor 10 years after brain tumor. 61
33378586 2021
3
Identification of prognostic immune-related genes in rhabdoid tumor of kidney based on TARGET database analysis. 61
33588380 2021
4
Identification of Potential Biomarkers of Prognosis-Related Long Non-Coding RNA (lncRNA) in Pediatric Rhabdoid Tumor of the Kidney Based on ceRNA Networks. 61
33328429 2020
5
Local Stage Dependent Necessity of Radiation Therapy in Rhabdoid Tumors of the Kidney (RTK). 61
32407933 2020
6
Lessons learned from the developmental origins of childhood renal cancer. 61
31738020 2020
7
Autologous Stem Cell Transplantation for Children With Renal Tumors, and Adults With Wilms Tumor: Retrospective Analysis of the Japanese Transplant Registry Unified Management Program. 61
32134841 2020
8
Identification of Biomarkers to Construct a Competing Endogenous RNA Network and Establishment of a Genomic-Clinicopathologic Nomogram to Predict Survival for Children with Rhabdoid Tumors of the Kidney. 61
32908900 2020
9
Texture Analysis to Differentiate Malignant Renal Tumors in Children Using Gray-Scale Ultrasonography Images. 61
31076232 2019
10
Co-existent Rhabdoid Tumor of The Kidney and Brain in a Male Infant: A Rare Case. 61
31632875 2019
11
Clinical and Prognostic Characteristics of 53 Cases of Extracranial Malignant Rhabdoid Tumor in Children. A Single-Institute Experience from 2007 to 2017. 61
30914466 2019
12
Anaplastic sarcoma of the kidney: Case report and literature review. 61
31007495 2019
13
INI1/SMARCB1-Deficient Carcinoma (Rhabdoid Tumor) of the Lacrimal Gland. 61
30856630 2019
14
Malignant rhabdoid tumor in a solitary kidney arising in an adult patient with chronic obstructive renal calculi. 61
31022624 2019
15
Specific computed tomography imaging characteristics of congenital mesoblastic nephroma and correlation with ultrasound and pathology. 61
30145031 2018
16
Factors Influencing Overall Survival of Children, Adolescents, and Young Adults With High-risk Renal Tumors. 61
30076944 2018
17
Outcome of renal tumors registered in Japan Wilms Tumor Study-2 (JWiTS-2): A report from the Japan Children's Cancer Group (JCCG). 61
29630767 2018
18
Synchronous Central Nervous System Atypical Teratoid/Rhabdoid Tumor and Malignant Rhabdoid Tumor of the Kidney: Case Report of a Long-Term Survivor and Review of the Literature. 61
29223518 2018
19
High-dose treatment for malignant rhabdoid tumor of the kidney: No evidence for improved survival-The Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH) experience. 61
28843054 2018
20
Rhabdoid Tumor Predisposition Syndrome 61
29215836 2017
21
Management of pediatric renal tumor: Past and future trials of the Japan Wilms Tumor Study Group. 61
26267611 2015
22
Malignant rhabdoid tumor of the kidney: significantly improved response to pre-operative treatment intensified with doxorubicin. 61
25242089 2014
23
Congenital multifocal rhabdoid tumor: a case with peculiar biological behavior and different response to treatment according to location (central nervous system and kidney). 61
25442925 2014
24
Rhabdoid tumor: the Irish experience 1986-2013. 61
25085603 2014
25
Rhabdoid tumors: integrating biological insights with clinical success: a report from the SMARCB1 and Rhabdoid Tumor Symposium, Paris, December 12-14, 2013. 61
25468731 2014
26
Malignant rhabdoid tumor of the kidney arising in an adult patient. 61
24982576 2014
27
Malignant rhabdoid tumor of the kidney and spine in an infant. 61
24570822 2014
28
[Clinical features of solid malignant tumors in childhood]. 61
23863721 2013
29
Long-term survivor of relapsed stage IV malignant rhabdoid tumor of the kidney. 61
23679167 2013
30
DNA methylation profile distinguishes clear cell sarcoma of the kidney from other pediatric renal tumors. 61
23638012 2013
31
Genetics of pediatric renal tumors. 61
22461142 2013
32
Primary lung metastases in pediatric malignant non-Wilms renal tumors: data from SIOP 93-01/GPOH and SIOP 2001/GPOH. 61
22513793 2012
33
The clinical course in pediatric solid tumor patients with focal nodular hyperplasia of the liver. 61
21455626 2011
34
Malignant rhabdoid tumor of the lung in the young adult: a case report. 61
22937424 2011
35
[Case report of rhabdoid tumor of the kidney occurring in own kidney following kidney transplantation from the living relative]. 61
20715500 2010
36
Malignant rhabdoid tumor of the kidney combined with multicystic dysplasia in a 5-year-old child. 61
20436719 2010
37
Outcome of pediatric renal tumor treated using the Japan Wilms Tumor Study-1 (JWiTS-1) protocol: a report from the JWiTS group. 61
19701757 2009
38
Chylous ascites after nephrectomy without lymphadenectomy for malignant rhabdoid tumor of the kidney: A rare occurrence and literature review. 61
20419024 2009
39
Long-term survival after autologous peripheral blood stem cell transplantation in two patients with malignant rhabdoid tumor of the kidney. 61
19260106 2009
40
Identification and metastatic potential of tumor-initiating cells in malignant rhabdoid tumor of the kidney. 61
19383826 2009
41
Rhabdoid tumor of the kidney with spontaneous rupture: case report and review of literature. 61
17492291 2008
42
Rhabdoid tumor of the kidney presenting with hemiplegia: report of a case. 61
17454778 2007
43
Association between the HER2 expression and histological differentiation in Wilms tumor. 61
16932912 2006
44
Predisposition to atypical teratoid/rhabdoid tumor due to an inherited INI1 mutation. 61
16261613 2006
45
Establishment and characterization of a new cell line, FRTK-1, derived from human malignant rhabdoid tumor of the kidney, with overexpression of epidermal growth factor receptor and cyclooxygenase-2. 61
16820901 2006
46
Classification of malignant pediatric renal tumors by gene expression. 61
16425275 2006
47
Treatment of stage IV malignant rhabdoid tumor of the kidney (MRTK) with ICE and VDCy: a case report. 61
16772877 2006
48
Radiology-Pathology Conference: rhabdoid tumor of the kidney. 61
16500545 2006
49
Molecular genetic alterations and gene expression profile of a malignant rhabdoid tumor of the kidney. 61
16337855 2005
50
Rhabdoid tumor of the kidney in the National Wilms' Tumor Study: age at diagnosis as a prognostic factor. 61
16234525 2005

Variations for Kidney Rhabdoid Cancer

Expression for Kidney Rhabdoid Cancer

Search GEO for disease gene expression data for Kidney Rhabdoid Cancer.

Pathways for Kidney Rhabdoid Cancer

Pathways related to Kidney Rhabdoid Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 SMARCC2 SMARCC1 SMARCB1 SMARCA4
2 11.96 SMARCC2 SMARCC1 SMARCB1 SMARCA4 EWSR1
3
Show member pathways
11.79 SMARCC2 SMARCC1 SMARCB1 SMARCA4
4 11.41 SMARCC2 SMARCC1 SMARCA4
5
Show member pathways
11.18 SMARCC2 SMARCC1 SMARCB1 SMARCA4
6
Show member pathways
10.77 SMARCC2 SMARCC1 SMARCB1 SMARCA4
7 10.65 YWHAE CCNB3

GO Terms for Kidney Rhabdoid Cancer

Cellular components related to Kidney Rhabdoid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.46 SMARCC2 SMARCC1 SMARCB1 SMARCA4
2 XY body GO:0001741 9.26 SMARCC1 SMARCB1
3 nBAF complex GO:0071565 9.26 SMARCC2 SMARCC1 SMARCB1 SMARCA4
4 npBAF complex GO:0071564 8.92 SMARCC2 SMARCC1 SMARCB1 SMARCA4

Biological processes related to Kidney Rhabdoid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.76 SMARCC2 SMARCC1 SMARCB1 SMARCA4
2 chromatin organization GO:0006325 9.71 SMARCC2 SMARCC1 SMARCB1 SMARCA4
3 chromatin remodeling GO:0006338 9.46 SMARCC2 SMARCC1 SMARCB1 SMARCA4
4 positive regulation by host of viral transcription GO:0043923 9.43 SMARCB1 SMARCA4
5 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 9.37 SMARCB1 SMARCA4
6 RNA polymerase I preinitiation complex assembly GO:0001188 9.32 SMARCB1 SMARCA4
7 positive regulation of glucose mediated signaling pathway GO:1902661 9.26 SMARCB1 SMARCA4
8 ATP-dependent chromatin remodeling GO:0043044 9.26 SMARCC2 SMARCC1 SMARCB1 SMARCA4
9 nucleosome disassembly GO:0006337 8.92 SMARCC2 SMARCC1 SMARCB1 SMARCA4

Molecular functions related to Kidney Rhabdoid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone binding GO:0042393 9.5 SMARCC2 SMARCC1 SMARCA4
2 Tat protein binding GO:0030957 9.26 SMARCB1 SMARCA4
3 transcription coactivator activity GO:0003713 9.26 SMARCC2 SMARCC1 SMARCB1 SMARCA4
4 RNA polymerase I CORE element sequence-specific DNA binding GO:0001164 9.16 SMARCB1 SMARCA4
5 nucleosomal DNA binding GO:0031492 8.92 SMARCC2 SMARCC1 SMARCB1 SMARCA4

Sources for Kidney Rhabdoid Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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