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MCID: KDN019
MIFTS: 37

Kidney Sarcoma

Categories: Cancer diseases, Nephrological diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Kidney Sarcoma

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MalaCards integrated aliases for Kidney Sarcoma:

Name: Kidney Sarcoma 12 15
Sarcoma of Kidney 12 74
Renal Sarcoma 12 30

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4242
NCIt 51 C4525
UMLS 74 C0346251
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Summaries for Kidney Sarcoma

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Disease Ontology : 12 A kidney cancer that is located in the kidney's connective tissue.

MalaCards based summary : Kidney Sarcoma, also known as sarcoma of kidney, is related to kidney clear cell sarcoma and clear cell sarcoma. An important gene associated with Kidney Sarcoma is BCOR (BCL6 Corepressor), and among its related pathways/superpathways are ErbB1 downstream signaling and mTOR signaling pathway (Pathway Interaction Database). The drugs Vincristine and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include kidney and t cells, and related phenotypes are cardiovascular system and mortality/aging

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Related Diseases for Kidney Sarcoma

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Diseases related to Kidney Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 kidney clear cell sarcoma 31.0 BCOR SATB2 YWHAE
2 clear cell sarcoma 29.9 BCOR YWHAE
3 kidney osteogenic sarcoma 11.0
4 kidney leiomyosarcoma 11.0
5 myxoid leiomyosarcoma 10.1 BCOR YWHAE
6 endometrial stromal nodule 10.1 BCOR YWHAE
7 endometrial stromal tumor 10.0 BCOR YWHAE
8 endometrial stromal sarcoma 9.9 BCOR YWHAE
9 sarcoma 9.9
10 small cell osteogenic sarcoma 9.9 BCOR SATB2
11 conventional central osteosarcoma 9.9 BCOR SATB2
12 bone osteosarcoma 9.9 BCOR SATB2
13 neuroblastoma 9.9
14 wilms tumor 5 9.9
15 wilms tumor 6 9.9
16 cleft lip/palate-ectodermal dysplasia syndrome 9.7 NECTIN1 SATB2
17 ewing sarcoma 9.7
18 small cell sarcoma 9.7
19 differentiating neuroblastoma 9.7
20 myeloid sarcoma 9.7
21 dicer1-related disorders 9.7
22 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 9.7
23 embryonal sarcoma 9.7
24 horseshoe kidney 9.7
25 orofacial cleft 9.7 NECTIN1 SATB2
26 renal cell carcinoma, nonpapillary 9.6
27 sarcoma, synovial 9.6
28 islet cell tumor 9.6
29 polycystic kidney disease 9.6
30 rhabdomyosarcoma 9.6
31 angiomyolipoma 9.6
32 spindle cell sarcoma 9.6
33 sarcomatoid renal cell carcinoma 9.6
34 kidney disease 9.6
35 hypoglycemia 9.6
36 soft tissue sarcoma 9.6
37 tooth agenesis 9.6 BCOR SATB2

Graphical network of the top 20 diseases related to Kidney Sarcoma:



Diseases related to Kidney Sarcoma
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Symptoms & Phenotypes for Kidney Sarcoma

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MGI Mouse Phenotypes related to Kidney Sarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 BCOR DICER1 PLD1 SATB2 YWHAE
2 mortality/aging MP:0010768 9.5 BCOR DICER1 DNAAF1 NECTIN1 PLD1 SATB2
3 craniofacial MP:0005382 9.46 DICER1 DNAAF1 NECTIN1 SATB2
4 nervous system MP:0003631 9.1 BCOR DICER1 DNAAF1 PLD1 SATB2 YWHAE
Sources

Drugs & Therapeutics for Kidney Sarcoma

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Drugs for Kidney Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 87)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
2
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 38904 10339178 498142
3
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
4
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
5
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
6
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 457193 2019
7
Lenograstim Approved, Investigational Phase 3,Phase 2 135968-09-1
8
Sulfamethoxazole Approved Phase 3 723-46-6 5329
9
Sargramostim Approved, Investigational Phase 3 123774-72-1, 83869-56-1
10
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
12
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
13
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1 51-75-2 4033
14
Cyproheptadine Approved Phase 3 129-03-3 2913
15
Histamine Approved, Investigational Phase 3 51-45-6 774
16
Doxil Approved June 1999 Phase 3,Phase 2 31703
17 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
18 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
19 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
20 Etoposide phosphate Phase 3,Phase 2,Phase 1
21 Anti-Infective Agents Phase 3,Phase 2,Phase 1
22 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
23 Immunologic Factors Phase 3,Phase 2,Phase 1
24 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
25 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
26 Alkylating Agents Phase 3,Phase 2,Phase 1
27 Antibiotics, Antitubercular Phase 3,Phase 2
28 Antimitotic Agents Phase 3,Phase 2,Phase 1,Not Applicable
29 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
30 Antirheumatic Agents Phase 3,Phase 2
31 Cola Phase 3,Phase 1,Phase 2,Not Applicable
32 Adjuvants, Immunologic Phase 3,Phase 2
33 Liver Extracts Phase 3,Phase 1,Phase 2,Not Applicable
34 Central Nervous System Depressants Phase 3
35 Peripheral Nervous System Agents Phase 3
36 Analgesics, Opioid Phase 3
37 Anesthetics Phase 3
38 Anesthetics, Intravenous Phase 3
39 Narcotics Phase 3
40 Analgesics Phase 3
41 Adjuvants, Anesthesia Phase 3
42 Anesthetics, General Phase 3
43
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
44 Dermatologic Agents Phase 3
45 Antipruritics Phase 3
46 Gastrointestinal Agents Phase 3
47 Histamine Antagonists Phase 3
48 Serotonin Agents Phase 3
49 Serotonin Antagonists Phase 3
50 Histamine H1 Antagonists Phase 3

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors Completed NCT00002610 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;vincristine sulfate
2 Combination Chemotherapy Alone or With Radiation Therapy in Treating Children With Kidney Cancer Completed NCT00002611 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;vincristine sulfate
3 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
4 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
5 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
6 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
7 Chemotherapy Followed by Surgery and Radiation Therapy With or Without Stem Cell Transplant in Treating Patients With Relapsed or Refractory Wilms' Tumor or Clear Cell Sarcoma of the Kidney Unknown status NCT00025103 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;melphalan;vincristine sulfate
8 Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors Completed NCT00335556 Phase 2 Doxorubicin Hydrochloride;Irinotecan Hydrochloride;Cyclophosphamide;Etoposide;Carboplatin;Vincristine Sulfate
9 Therapeutic Angiotensin-(1-7) in Treating Patients With Metastatic Sarcoma That Cannot Be Removed By Surgery Completed NCT01553539 Phase 2 therapeutic angiotensin-(1-7)
10 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
11 Chemotherapy in Treating Patients With Solid Tumors Completed NCT00003103 Phase 1, Phase 2 docetaxel
12 High-dose ICE With Amifostine Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
13 Sunitinib Malate With or Without Gemcitabine Hydrochloride in Treating Patients With Advanced Kidney Cancer That Cannot Be Removed By Surgery Active, not recruiting NCT01164228 Phase 2 gemcitabine hydrochloride;sunitinib malate
14 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
15 Dalteparin and Sunitinib Malate as First-Line Therapy in Treating Patients With Kidney Cancer That is Metastatic or Cannot Be Removed by Surgery Completed NCT01061411 Phase 1 Dalteparin;Sunitinib Malate
16 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
17 Study of Information Received About Fertility and Infertility in Patients Who Have Finished Treatment for Cancer Unknown status NCT01295463
18 Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom Unknown status NCT00757614
19 Biomarkers in Tissue Samples From Patients With High-Risk Wilms Tumor Completed NCT01118078
20 E-MOSAIC Electronic Tool to Monitor Symptoms Completed NCT00477919
21 Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients Completed NCT00253383 Not Applicable
22 Pencil Beam Scanning in Patients With Renal Tumors Recruiting NCT03810651 Early Phase 1
23 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
24 Study of Kidney Tumors in Younger Patients Recruiting NCT00898365
25 Studying Biomarkers in Samples From Younger Patients With Kidney Cancer Withdrawn NCT01642095
26 Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Advanced or Refractory Solid Tumors Withdrawn NCT00499291 Not Applicable paclitaxel albumin-stabilized nanoparticle formulation

Search NIH Clinical Center for Kidney Sarcoma

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Genetic Tests for Kidney Sarcoma

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Genetic tests related to Kidney Sarcoma:

# Genetic test Affiliating Genes
1 Renal Sarcoma 30
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Anatomical Context for Kidney Sarcoma

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MalaCards organs/tissues related to Kidney Sarcoma:

42
Kidney, T Cells
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Publications for Kidney Sarcoma

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Articles related to Kidney Sarcoma:

(show all 42)
# Title Authors Year
1
Expression of cyclin D1 in clear cell sarcoma of kidney. Is it useful in differentiating it from its histological mimics? ( 30736802 )
2019
2
BCOR Overexpression in Renal Malignant Solitary Fibrous Tumors: A Close Mimic of Clear Cell Sarcoma of Kidney. ( 30864973 )
2019
3
Primary Low-Grade Fibromyxoid Sarcoma of Kidney-an Extremely Rare Entity. ( 29973762 )
2018
4
Delayed Metastasis of Clear Cell Sarcoma of Kidney to Bladder After 7 Disease-Free Years. ( 29509095 )
2018
5
Ewing's sarcoma of kidney in a 60-year-old patient with local recurrence: A rare occurrence. ( 30488867 )
2018
6
FNAC aided diagnosis of clear cell sarcoma of kidney: Report of two cases in infants. ( 28421721 )
2017
7
Clear cell sarcoma of kidney involving a horseshoe kidney and harboring EGFR internal tandem duplication. ( 28440018 )
2017
8
Concurrent occurrence of neuroblastoma and clear cell sarcoma of kidney in an infant: Is it a random event? ( 28195107 )
2017
9
Primary Renal Sarcomas With BCOR-CCNB3 Gene Fusion: A Report of 2 Cases Showing Histologic Overlap With Clear Cell Sarcoma of Kidney, Suggesting Further Link Between BCOR-related Sarcomas of the Kidney and Soft Tissues. ( 28817404 )
2017
10
Dual tumor - Clear cell sarcoma of kidney with differentiating neuroblastoma: A rare case with review of literature. ( 28195106 )
2017
11
Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney. ( 26945340 )
2016
12
Mutually exclusive BCOR internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney: not the full story. ( 27000436 )
2016
13
Evolution of Renal Cysts to Anaplastic Sarcoma of Kidney in a Child With DICER1 Syndrome. ( 26928971 )
2016
14
Synovial sarcoma of kidney in a child: A rare presentation. ( 27046979 )
2016
15
Primary synovial sarcoma of kidney: a rare differential diagnosis of renomegaly. ( 25610686 )
2014
16
Clear cell sarcoma of kidney in a neonate. ( 26023506 )
2014
17
Clear cell sarcoma of kidney: morphoproteomic analysis reveals genomic correlates and therapeutic options. ( 22256788 )
2013
18
Outcomes of patients with revised stage I clear cell sarcoma of kidney treated in National Wilms Tumor Studies 1-5. ( 22658515 )
2013
19
Characterization of the chromosomal translocation t(10;17)(q22;p13) in clear cell sarcoma of kidney. ( 22294382 )
2012
20
Primary Ewing sarcoma of kidney in an elderly. ( 22797102 )
2012
21
Clear cell sarcoma of kidney: A rare entity. ( 22557783 )
2011
22
Nonleukemic granulocytic sarcoma of kidney with mixed phenotype blasts: a diagnostic dilemma. ( 21934235 )
2011
23
Primary synovial sarcoma of kidney-a report of 2 cases and review of literature. ( 21863065 )
2010
24
Primary synovial sarcoma of kidney: A rare tumor with an atypical presentation. ( 19672366 )
2009
25
Translocation (10;17)(q22;p13): a recurring translocation in clear cell sarcoma of kidney. ( 15474157 )
2004
26
Transfer of IFNgamma-depleted CD4(+) T cells together with CD8(+) T cells leads to rejection of murine kidney sarcoma in mice. ( 10925361 )
2000
27
Clear cell sarcoma of kidney in an adolescent and in young adults: a report of four cases with ultrastructural, immunohistochemical, and DNA flow cytometric analysis. ( 10584698 )
1999
28
Veno-occlusive disease-like hepatotoxicity in two children receiving chemotherapy for Wilms' tumor and clear cell sarcoma of kidney. ( 9509511 )
1998
29
Cystic embryonal sarcoma of kidney: a case report. ( 9635536 )
1998
30
Clear cell sarcoma of kidney with tumor extension into the right atrium. ( 9788798 )
1998
31
Clear cell sarcoma of kidney in an adult. ( 8149160 )
1993
32
Clear cell sarcoma of kidney. Two cases in adults. ( 8453549 )
1993
33
Clear cell sarcoma of kidney: a clinicopathological study of eight cases from Malaysia. ( 1328018 )
1992
34
Clear cell sarcoma of kidney: report of the first Malaysian case. ( 1374551 )
1992
35
Nondifferentiated-type small cell sarcoma of kidney in a young woman. ( 1871901 )
1991
36
Primitive pelvic sarcoma resembling clear cell sarcoma of kidney. ( 1755102 )
1991
37
Clear cell sarcoma of kidney (CCSK)--a clinicopathological study of 4 cases. ( 2591997 )
1989
38
Case 7. Clear cell sarcoma of kidney. ( 2748484 )
1989
39
Embryonic Sarcoma of Kidney. ( 19985727 )
1927
40
SPONTANEOUS HAEMATOMA IN SARCOMA OF KIDNEY. ( 17864796 )
1923
41
VI. Sarcoma of Kidney in an Infant; Recovery after Nephrectomy. ( 17860750 )
1899
42
Sarcoma of Kidney and Lungs. ( 20748227 )
1876
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Variations for Kidney Sarcoma

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Expression for Kidney Sarcoma

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Search GEO for disease gene expression data for Kidney Sarcoma.
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Pathways for Kidney Sarcoma

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Pathways related to Kidney Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
ErbB1 downstream signaling 1
11.16 PLD1 YWHAE
2
mTOR signaling pathway (Pathway Interaction Database) 1
10.74 PLD1 YWHAE
3
Signaling events mediated by HDAC Class II 1
10.15 BCOR YWHAE
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GO Terms for Kidney Sarcoma

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Cellular components related to Kidney Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.8 DICER1 NECTIN1 YWHAE

Biological processes related to Kidney Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 roof of mouth development GO:0060021 8.62 BCOR SATB2

Molecular functions related to Kidney Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone deacetylase binding GO:0042826 8.62 BCOR YWHAE
Sources

Sources for Kidney Sarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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