MCID: KDN019
MIFTS: 36

Kidney Sarcoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Kidney Sarcoma

MalaCards integrated aliases for Kidney Sarcoma:

Name: Kidney Sarcoma 12 15
Sarcoma of Kidney 12 73
Renal Sarcoma 12 29

Classifications:



External Ids:

Disease Ontology 12 DOID:4242
NCIt 50 C4525
SNOMED-CT 68 254918001
UMLS 73 C0346251

Summaries for Kidney Sarcoma

Disease Ontology : 12 A kidney cancer that is located in the kidney's connective tissue.

MalaCards based summary : Kidney Sarcoma, also known as sarcoma of kidney, is related to kidney clear cell sarcoma and kidney osteogenic sarcoma. An important gene associated with Kidney Sarcoma is DICER1 (Dicer 1, Ribonuclease III), and among its related pathways/superpathways is Tyrosine metabolism. The drugs Etoposide and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include the kidney's connective tissue, kidney and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Kidney Sarcoma

Diseases related to Kidney Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 kidney clear cell sarcoma 31.0 TH WT1
2 kidney osteogenic sarcoma 10.8
3 testicular granulosa cell tumor 10.0 DICER1 WT1
4 juvenile type testicular granulosa cell tumor 9.9 DICER1 WT1
5 cystic nephroma 9.9 DICER1 WT1
6 sertoli-leydig cell tumor 9.8 DICER1 WT1
7 dysgerminoma of ovary 9.8 DICER1 WT1
8 sex cord-gonadal stromal tumor 9.7 DICER1 WT1
9 sarcoma 9.7
10 rhabdomyosarcoma 2 9.5 TH WT1
11 beckwith-wiedemann syndrome 9.2 TH WT1

Graphical network of the top 20 diseases related to Kidney Sarcoma:



Diseases related to Kidney Sarcoma

Symptoms & Phenotypes for Kidney Sarcoma

GenomeRNAi Phenotypes related to Kidney Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.36 DICER1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.36 DICER1 HPD WT1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.36 DICER1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.36 HPD
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.36 HPD
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.36 HPD
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.36 DICER1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.36 HPD
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.36 HPD
10 Decreased melanin production GR00056-A 8.96 HPD SLC17A5

MGI Mouse Phenotypes related to Kidney Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.55 DICER1 NECTIN1 SLC17A5 TH WT1
2 homeostasis/metabolism MP:0005376 9.43 HPD NECTIN1 SLC17A5 TH WT1 DICER1
3 vision/eye MP:0005391 8.92 DICER1 NECTIN1 SLC17A5 TH

Drugs & Therapeutics for Kidney Sarcoma

Drugs for Kidney Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
2
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
3
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
4
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
6
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 2019 457193
7
Lenograstim Approved, Investigational Phase 3,Phase 2 135968-09-1
8
Sulfamethoxazole Approved Phase 3 723-46-6 5329
9
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1 51-75-2 4033
10
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
11
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
12
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
13
Cyproheptadine Approved Phase 3 129-03-3 2913
14
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
15
Doxil Approved June 1999 Phase 3,Phase 2 31703
16 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
17 Alkylating Agents Phase 3,Phase 2,Phase 1
18 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
19 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
20 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
21 Antibiotics, Antitubercular Phase 3,Phase 2
22 Etoposide phosphate Phase 3,Phase 2,Phase 1
23 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
24 Anti-Infective Agents Phase 3,Phase 2,Phase 1
25 Antirheumatic Agents Phase 3,Phase 2
26 Antimitotic Agents Phase 3,Phase 2,Phase 1,Not Applicable
27 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
28 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
29
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
30 Analgesics Phase 3
31 Central Nervous System Depressants Phase 3
32 Adjuvants, Anesthesia Phase 3
33 Adjuvants, Immunologic Phase 3,Phase 2
34 Narcotics Phase 3
35 Analgesics, Opioid Phase 3
36 Anesthetics Phase 3
37 Anesthetics, General Phase 3
38 Anesthetics, Intravenous Phase 3
39 Peripheral Nervous System Agents Phase 3
40 Liver Extracts Phase 3,Phase 1,Phase 2,Not Applicable
41
Histamine Phosphate Phase 3 51-74-1 65513
42 Serotonin Agents Phase 3
43 Serotonin Antagonists Phase 3
44 Gastrointestinal Agents Phase 3
45 Neurotransmitter Agents Phase 3
46 Histamine Antagonists Phase 3
47 Histamine H1 Antagonists Phase 3
48 Dermatologic Agents Phase 3
49 Anti-Allergic Agents Phase 3
50 Antipruritics Phase 3

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors Completed NCT00002610 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;vincristine sulfate
2 Combination Chemotherapy Alone or With Radiation Therapy in Treating Children With Kidney Cancer Completed NCT00002611 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;vincristine sulfate
3 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
4 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
5 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
6 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
7 Chemotherapy Followed by Surgery and Radiation Therapy With or Without Stem Cell Transplant in Treating Patients With Relapsed or Refractory Wilms' Tumor or Clear Cell Sarcoma of the Kidney Unknown status NCT00025103 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;melphalan;vincristine sulfate
8 Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors Completed NCT00335556 Phase 2 Doxorubicin Hydrochloride;Irinotecan Hydrochloride;Cyclophosphamide;Etoposide;Carboplatin;Vincristine Sulfate
9 Therapeutic Angiotensin-(1-7) in Treating Patients With Metastatic Sarcoma That Cannot Be Removed By Surgery Completed NCT01553539 Phase 2 therapeutic angiotensin-(1-7)
10 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
11 Chemotherapy in Treating Patients With Solid Tumors Completed NCT00003103 Phase 1, Phase 2 docetaxel
12 High-dose ICE With Amifostine Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
13 Sunitinib Malate With or Without Gemcitabine Hydrochloride in Treating Patients With Advanced Kidney Cancer That Cannot Be Removed By Surgery Active, not recruiting NCT01164228 Phase 2 gemcitabine hydrochloride;sunitinib malate
14 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
15 Dalteparin and Sunitinib Malate as First-Line Therapy in Treating Patients With Kidney Cancer That is Metastatic or Cannot Be Removed by Surgery Completed NCT01061411 Phase 1 Dalteparin;Sunitinib Malate
16 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
17 Study of Information Received About Fertility and Infertility in Patients Who Have Finished Treatment for Cancer Unknown status NCT01295463
18 Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom Unknown status NCT00757614
19 Biomarkers in Tissue Samples From Patients With High-Risk Wilms Tumor Completed NCT01118078
20 E-MOSAIC Electronic Tool to Monitor Symptoms Completed NCT00477919
21 Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients Completed NCT00253383 Not Applicable
22 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
23 Study of Kidney Tumors in Younger Patients Recruiting NCT00898365
24 Studying Biomarkers in Samples From Younger Patients With Kidney Cancer Withdrawn NCT01642095
25 Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Advanced or Refractory Solid Tumors Withdrawn NCT00499291 Not Applicable paclitaxel albumin-stabilized nanoparticle formulation

Search NIH Clinical Center for Kidney Sarcoma

Genetic Tests for Kidney Sarcoma

Genetic tests related to Kidney Sarcoma:

# Genetic test Affiliating Genes
1 Renal Sarcoma 29

Anatomical Context for Kidney Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Kidney Sarcoma:

19
The Kidney'S Connective Tissue

MalaCards organs/tissues related to Kidney Sarcoma:

41
Kidney, Lung, Liver, T Cells

Publications for Kidney Sarcoma

Articles related to Kidney Sarcoma:

(show all 31)
# Title Authors Year
1
Primary Low-Grade Fibromyxoid Sarcoma of Kidney-an Extremely Rare Entity. ( 29973762 )
2018
2
Delayed Metastasis of Clear Cell Sarcoma of Kidney to Bladder After 7 Disease-Free Years. ( 29509095 )
2018
3
FNAC aided diagnosis of clear cell sarcoma of kidney: Report of two cases in infants. ( 28421721 )
2017
4
Clear cell sarcoma of kidney involving a horseshoe kidney and harboring EGFR internal tandem duplication. ( 28440018 )
2017
5
Concurrent occurrence of neuroblastoma and clear cell sarcoma of kidney in an infant: Is it a random event? ( 28195107 )
2017
6
Primary Renal Sarcomas With BCOR-CCNB3 Gene Fusion: A Report of 2 Cases Showing Histologic Overlap With Clear Cell Sarcoma of Kidney, Suggesting Further Link Between BCOR-related Sarcomas of the Kidney and Soft Tissues. ( 28817404 )
2017
7
Dual tumor - Clear cell sarcoma of kidney with differentiating neuroblastoma: A rare case with review of literature. ( 28195106 )
2017
8
Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney. ( 26945340 )
2016
9
Mutually exclusive BCOR internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney: not the full story. ( 27000436 )
2016
10
Primary synovial sarcoma of kidney: a rare differential diagnosis of renomegaly. ( 25610686 )
2014
11
Clear cell sarcoma of kidney in a neonate. ( 26023506 )
2014
12
Clear cell sarcoma of kidney: morphoproteomic analysis reveals genomic correlates and therapeutic options. ( 22256788 )
2013
13
Outcomes of patients with revised stage I clear cell sarcoma of kidney treated in National Wilms Tumor Studies 1-5. ( 22658515 )
2013
14
Characterization of the chromosomal translocation t(10;17)(q22;p13) in clear cell sarcoma of kidney. ( 22294382 )
2012
15
Clear cell sarcoma of kidney: A rare entity. ( 22557783 )
2011
16
Primary synovial sarcoma of kidney-a report of 2 cases and review of literature. ( 21863065 )
2010
17
Primary synovial sarcoma of kidney: A rare tumor with an atypical presentation. ( 19672366 )
2009
18
Translocation (10;17)(q22;p13): a recurring translocation in clear cell sarcoma of kidney. ( 15474157 )
2004
19
Transfer of IFNgamma-depleted CD4(+) T cells together with CD8(+) T cells leads to rejection of murine kidney sarcoma in mice. ( 10925361 )
2000
20
Clear cell sarcoma of kidney in an adolescent and in young adults: a report of four cases with ultrastructural, immunohistochemical, and DNA flow cytometric analysis. ( 10584698 )
1999
21
Veno-occlusive disease-like hepatotoxicity in two children receiving chemotherapy for Wilms' tumor and clear cell sarcoma of kidney. ( 9509511 )
1998
22
Cystic embryonal sarcoma of kidney: a case report. ( 9635536 )
1998
23
Clear cell sarcoma of kidney with tumor extension into the right atrium. ( 9788798 )
1998
24
Clear cell sarcoma of kidney in an adult. ( 8149160 )
1993
25
Clear cell sarcoma of kidney. Two cases in adults. ( 8453549 )
1993
26
Clear cell sarcoma of kidney: a clinicopathological study of eight cases from Malaysia. ( 1328018 )
1992
27
Clear cell sarcoma of kidney: report of the first Malaysian case. ( 1374551 )
1992
28
Nondifferentiated-type small cell sarcoma of kidney in a young woman. ( 1871901 )
1991
29
Primitive pelvic sarcoma resembling clear cell sarcoma of kidney. ( 1755102 )
1991
30
Clear cell sarcoma of kidney (CCSK)--a clinicopathological study of 4 cases. ( 2591997 )
1989
31
Case 7. Clear cell sarcoma of kidney. ( 2748484 )
1989

Variations for Kidney Sarcoma

Expression for Kidney Sarcoma

Search GEO for disease gene expression data for Kidney Sarcoma.

Pathways for Kidney Sarcoma

Pathways related to Kidney Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.5 HPD TH

GO Terms for Kidney Sarcoma

Cellular components related to Kidney Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.8 DICER1 NECTIN1 TH

Biological processes related to Kidney Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aromatic amino acid family metabolic process GO:0009072 8.62 HPD TH

Sources for Kidney Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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