MCID: KNB002
MIFTS: 25

Kienbock's Disease

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Kienbock's Disease

MalaCards integrated aliases for Kienbock's Disease:

Name: Kienbock's Disease 20
Kienbock Disease 20 58 70
Bilateral Kienbock's Disease 20 70
Progressive Avascular Necrosis of the Lunate Bone 58
Aseptic Necrosis of the Lunate Bone 58
Osteochondrosis of the Lunate Bone 58
Lunatomalacia 58

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


External Ids:

ICD10 via Orphanet 33 M92.2 M93.1
UMLS via Orphanet 71 C0022682
Orphanet 58 ORPHA97332
UMLS 70 C0022682 C2931883

Summaries for Kienbock's Disease

GARD : 20 Kienbock's disease causes one of the bones in the wrist (lunate bone) to slowly break down due to low blood supply. This process is called osteonecrosis. Symptoms include pain, swelling, limited movement, and decreased grip strength. The symptoms usually start in adulthood, but can occur at any age. Kienbock's disease usually slowly gets worse over time. The underlying cause of Kienbock's disease is unknown. Diagnosis is made by imaging studies such as an MRI or CT scan. Treatment aims to relieve pressure and restore blood flow within the bone, and includes both surgical and non-surgical methods.

MalaCards based summary : Kienbock's Disease, also known as kienbock disease, is related to avascular necrosis and osteonecrosis. Affiliated tissues include bone and bone marrow, and related phenotypes are arthralgia and limitation of joint mobility

Related Diseases for Kienbock's Disease

Diseases related to Kienbock's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 avascular necrosis 10.5
2 osteonecrosis 10.5
3 plica syndrome 10.3
4 synovitis 10.3
5 legg-calve-perthes disease 10.1
6 carpal tunnel syndrome 10.0
7 b-lymphoblastic leukemia/lymphoma 10.0
8 dermatomyositis 10.0
9 osteomalacia 10.0
10 cerebral palsy 10.0
11 thrombophilia 10.0
12 complex regional pain syndrome 10.0
13 juvenile rheumatoid arthritis 10.0
14 vasculitis 10.0
15 factor v leiden thrombophilia 10.0
16 trichorhinophalangeal syndrome, type ii 9.9
17 pseudopseudohypoparathyroidism 9.9
18 synostosis 9.9

Graphical network of the top 20 diseases related to Kienbock's Disease:



Diseases related to Kienbock's Disease

Symptoms & Phenotypes for Kienbock's Disease

Human phenotypes related to Kienbock's Disease:

58 31 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002829
2 limitation of joint mobility 58 31 hallmark (90%) Very frequent (99-80%) HP:0001376
3 bone pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0002653
4 abnormality of the wrist 58 31 hallmark (90%) Very frequent (99-80%) HP:0003019
5 osteochondritis dissecans 58 31 hallmark (90%) Very frequent (99-80%) HP:0010886
6 osteoarthritis 58 31 frequent (33%) Frequent (79-30%) HP:0002758
7 avascular necrosis 58 Very frequent (99-80%)

Drugs & Therapeutics for Kienbock's Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Autologous Bone Marrow Derived Mesenchymal Stromal Cells Transplantation for Human Avascular Necrosis of the Lunate Bone of the Wrist (Kienbock's Disease) Unknown status NCT02646007 Phase 1
2 Kienbock Disease Radiographic Guided Treatment Versus Arthroscopic Guided Treatment Unknown status NCT03291015

Search NIH Clinical Center for Kienbock's Disease

Genetic Tests for Kienbock's Disease

Anatomical Context for Kienbock's Disease

MalaCards organs/tissues related to Kienbock's Disease:

40
Bone, Bone Marrow

Publications for Kienbock's Disease

Articles related to Kienbock's Disease:

(show top 50) (show all 164)
# Title Authors PMID Year
1
Treatment of Stages IIIA and IIIB in Kienbock's Disease: A Systematic Review. 61
33282541 2020
2
Single-Cut Single-Screw Capitate-Shortening Osteotomy for Kienbock's Disease. 61
32760605 2020
3
Kienböck Disease: Quality, Accuracy, and Readability of Online Information. 61
30556422 2020
4
The use of Carbon-Peek volar plate after distal radius osteotomy for Kienbock's Disease in a volleyball athlete: a case report. 61
31821300 2019
5
Analysis of Radiographic Relationship between Distal Radius, Ulna, and Lunate. 61
31579545 2019
6
Treatment of Advanced Kienbock's Disease (Lichtman Stage IIIB with Carpal Collapse) by a Shortening Osteotomy of the Radius: 21 Cases. 61
31404372 2019
7
The Efficacy of Vascularized Bone Grafts in the Treatment of Scaphoid Nonunions and Kienbock Disease: A Systematic Review in 917 Patients. 61
30911206 2019
8
Four-Dimensional Computed Tomography Scanning for Dynamic Wrist Disorders: Prospective Analysis and Recommendations for Clinical Utility. 61
30941259 2019
9
Intra- and Inter-observer Variability in Different Methods of Measuring Carpal Collapse. 61
31001379 2019
10
LUNATE DISLOCATION: PRESENTATION OF TWO CASES OF A RARE CONDITION. 61
33553055 2018
11
Radiologic Guide to Surgical Treatment of Kienbock's Disease. 61
28619441 2018
12
The Role of Wrist Arthroscopy in Kienbock Disease. 61
28991584 2017
13
Treatment of gout combined with Kienböck's disease: A case report. 61
29067099 2017
14
Percutaneous Cementoplasty for Kienbock's Disease. 61
28275828 2017
15
Bilateral Legg-Calve-Perthes Disease and Kienbock's Disease in a Child With Factor V Leiden Thrombophilia: A Case Report. 61
27698645 2016
16
Factors associated with improved outcomes following proximal row carpectomy: a long-term outcome study of 144 patients. 61
26228698 2016
17
Avascular necrosis of lunate bone: Kienbock disease. 61
26682674 2016
18
Distal Radius Radiographic Indices and Perilunate Fracture Dislocation. 61
27626004 2016
19
Load distribution on the radio-carpal joint for carpal arthrodesis. 61
26787512 2016
20
Limited intercarpal fusion as a salvage procedure for advanced Kienbock disease. 61
26330780 2015
21
Is arthrodesis still a good indication for non-inflammatory arthrosis of the wrist? 61
26535206 2015
22
Kienbock Disease: A Complicated Postsurgical Case Study Using Diagnostic Ultrasonography. 61
26257591 2015
23
(99m)Tc-MDP SPECT/CT as the one-stop imaging modality for the diagnosis of early setting of Kienbock's disease. 61
25824583 2015
24
Mid-term clinical outcome of radial shortening for kienbock disease. 61
25983766 2015
25
Kienbock's disease and scapholunate advanced collapse. 61
25198349 2014
26
Scaphocapitate arthrodesis for treatment of late stage Kienbock disease. 61
23824220 2014
27
Long-term outcome (22-36 years) of silicone lunate arthroplasty for Kienbock's disease. 61
23695152 2014
28
Avascular necrosis of the lunate bone (Kienböck's disease) secondary to scapholunate ligament tear as a consequence of trauma - a case study. 61
24523832 2014
29
Re: Werber et al. Biomechanical effect of isolated capitate shortening in Kienbock's disease: an anatomical study. J Hand Surg Eur. 2013, 38: 500-7. 61
23974604 2013
30
A hand therapy protocol for the treatment of lunate overload or early Kienbock's disease. 61
23465629 2013
31
Radiological and anatomical study to investigate possibility of relationship between scaphoid fracture and lunate morphology. 61
24431268 2013
32
Long-term results after resection arthroplasty in Kienbock's disease. 61
22618553 2013
33
The association of Kienbock's disease and ulnar variance in the Iranian population. 61
23221184 2013
34
The value of delayed MRI scans in the assessment of acute wrist injuries. 61
23926729 2013
35
Long-term clinical results and MRI changes after tendon ball arthroplasty for advanced Kienbock's disease. 61
23303835 2013
36
Biomechanical effect of isolated capitate shortening in Kienbock's disease: an anatomical study. 61
22918882 2013
37
Bilateral Kienbock's disease concomitant with bilateral Legg-Calvé-Perthes disease: a case report. 61
24426907 2013
38
Kienbock's disease and scapholunate dissociation after acute wrist trauma. 61
24426899 2013
39
Proximal row carpectomy. 61
23168029 2013
40
Kienbock's disease in a varsity football player: a case report and review of the literature. 61
23204571 2012
41
Radial shortening osteotomy in advanced stages of Kienbock disease. 61
23160560 2012
42
Distal radius osteotomy with intramedullary fixation for the treatment of Kienbock disease. 61
22913997 2012
43
Bilateral Kienbock's disease in association with type 1 diabetes. 61
22427280 2012
44
Proximal row carpectomy with capitate osteochondral autograft transplantation. 61
22627929 2012
45
Trabecular microstructure of the human lunate in Kienbock's disease. 61
21965181 2012
46
Kienbock's disease: percutaneous cement lunatoplasty--a cadaver study. 61
22067297 2012
47
Decompression effect of partial capitate shortening for Kienbock's disease: a biomechanical study. 61
23061936 2012
48
Kienbock's Disease treated with Interposition Arthroplasty using Ipsilateral Palmaris Longus Tendon and Muscle Belly. 61
27298845 2012
49
Kienbock's disease and juvenile idiopathic arthritis. 61
22363188 2011
50
Kienbock's Disease in a Child. 61
23358501 2011

Variations for Kienbock's Disease

Expression for Kienbock's Disease

Search GEO for disease gene expression data for Kienbock's Disease.

Pathways for Kienbock's Disease

GO Terms for Kienbock's Disease

Sources for Kienbock's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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