MCID: KNB002
MIFTS: 24

Kienbock's Disease

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Kienbock's Disease

MalaCards integrated aliases for Kienbock's Disease:

Name: Kienbock's Disease 52
Kienbock Disease 52 58 71
Bilateral Kienbock's Disease 52 71
Aseptic Necrosis of the Lunate Bone 58
Osteochondrosis of the Lunate Bone 58
Lunatomalacia 58

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


External Ids:

ICD10 via Orphanet 33 M92.2 M93.2
UMLS via Orphanet 72 C0022682
Orphanet 58 ORPHA97332
UMLS 71 C0022682 C2931883

Summaries for Kienbock's Disease

NIH Rare Diseases : 52 Kienbock's disease is a condition characterized by interruption of blood supply to one of the small bones of the hand near the wrist (the lunate ). If blood supply to a bone stops, the bone can die; this is known as osteonecrosis . Affected people may first think they have a sprained wrist and may have experienced trauma to the wrist, which can disrupt the blood flow to the lunate. As the disease progresses, signs and symptoms may include a painful and/or swollen wrist; stiffness; decreased grip strength; tenderness directly over the bone; and pain or difficulty in turning the hand upward. The underlying cause of Kienbock's disease is unknown. Treatment aims to relieve the pressure on the bone and restore blood flow within the bone. Surgery may be recommended.

MalaCards based summary : Kienbock's Disease, also known as kienbock disease, is related to avascular necrosis and osteonecrosis. Affiliated tissues include bone, and related phenotypes are arthralgia and limitation of joint mobility

Related Diseases for Kienbock's Disease

Diseases related to Kienbock's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 avascular necrosis 10.6
2 osteonecrosis 10.6
3 synovitis 10.4
4 legg-calve-perthes disease 10.2
5 arthritis 10.2
6 trichorhinophalangeal syndrome, type ii 10.2
7 pseudopseudohypoparathyroidism 10.2
8 synostosis 10.2
9 48,xyyy 10.2
10 carpal tunnel syndrome 10.1
11 systemic lupus erythematosus 10.1
12 rheumatoid arthritis 10.1
13 leukemia, acute lymphoblastic 3 10.1
14 dermatomyositis 10.1
15 osteomalacia 10.1
16 cerebral palsy 10.1
17 thrombophilia 10.1
18 complex regional pain syndrome 10.1
19 juvenile rheumatoid arthritis 10.1
20 vasculitis 10.1
21 factor v leiden thrombophilia 10.1

Graphical network of the top 20 diseases related to Kienbock's Disease:



Diseases related to Kienbock's Disease

Symptoms & Phenotypes for Kienbock's Disease

Human phenotypes related to Kienbock's Disease:

58 31 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002829
2 limitation of joint mobility 58 31 hallmark (90%) Very frequent (99-80%) HP:0001376
3 bone pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0002653
4 abnormality of the wrist 58 31 hallmark (90%) Very frequent (99-80%) HP:0003019
5 osteochondritis dissecans 58 31 hallmark (90%) Very frequent (99-80%) HP:0010886
6 osteoarthritis 58 31 frequent (33%) Frequent (79-30%) HP:0002758
7 aseptic necrosis 58 Very frequent (99-80%)

Drugs & Therapeutics for Kienbock's Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Kienbock Disease Radiographic Guided Treatment Versus Arthroscopic Guided Treatment Unknown status NCT03291015

Search NIH Clinical Center for Kienbock's Disease

Genetic Tests for Kienbock's Disease

Anatomical Context for Kienbock's Disease

MalaCards organs/tissues related to Kienbock's Disease:

40
Bone

Publications for Kienbock's Disease

Articles related to Kienbock's Disease:

(show top 50) (show all 161)
# Title Authors PMID Year
1
The use of Carbon-Peek volar plate after distal radius osteotomy for Kienbock's Disease in a volleyball athlete: a case report. 61
31821300 2019
2
Analysis of Radiographic Relationship between Distal Radius, Ulna, and Lunate. 61
31579545 2019
3
Treatment of Advanced Kienbock's Disease (Lichtman Stage IIIB with Carpal Collapse) by a Shortening Osteotomy of the Radius: 21 Cases. 61
31404372 2019
4
Four-Dimensional Computed Tomography Scanning for Dynamic Wrist Disorders: Prospective Analysis and Recommendations for Clinical Utility. 61
30941259 2019
5
The Efficacy of Vascularized Bone Grafts in the Treatment of Scaphoid Nonunions and Kienbock Disease: A Systematic Review in 917 Patients. 61
30911206 2019
6
Intra- and Inter-observer Variability in Different Methods of Measuring Carpal Collapse. 61
31001379 2019
7
Kienböck Disease: Quality, Accuracy, and Readability of Online Information. 61
30556422 2018
8
Radiologic Guide to Surgical Treatment of Kienbock's Disease. 61
28619441 2018
9
Treatment of gout combined with Kienböck's disease: A case report. 61
29067099 2017
10
The Role of Wrist Arthroscopy in Kienbock Disease. 61
28991584 2017
11
Percutaneous Cementoplasty for Kienbock's Disease. 61
28275828 2017
12
Bilateral Legg-Calve-Perthes Disease and Kienbock's Disease in a Child With Factor V Leiden Thrombophilia: A Case Report. 61
27698645 2016
13
Factors associated with improved outcomes following proximal row carpectomy: a long-term outcome study of 144 patients. 61
26228698 2016
14
Avascular necrosis of lunate bone: Kienbock disease. 61
26682674 2016
15
Distal Radius Radiographic Indices and Perilunate Fracture Dislocation. 61
27626004 2016
16
Load distribution on the radio-carpal joint for carpal arthrodesis. 61
26787512 2016
17
Is arthrodesis still a good indication for non-inflammatory arthrosis of the wrist? 61
26535206 2015
18
Limited intercarpal fusion as a salvage procedure for advanced Kienbock disease. 61
26330780 2015
19
Kienbock Disease: A Complicated Postsurgical Case Study Using Diagnostic Ultrasonography. 61
26257591 2015
20
(99m)Tc-MDP SPECT/CT as the one-stop imaging modality for the diagnosis of early setting of Kienbock's disease. 61
25824583 2015
21
Mid-term clinical outcome of radial shortening for kienbock disease. 61
25983766 2015
22
Kienbock's disease and scapholunate advanced collapse. 61
25198349 2014
23
Long-term outcome (22-36 years) of silicone lunate arthroplasty for Kienbock's disease. 61
23695152 2014
24
Scaphocapitate arthrodesis for treatment of late stage Kienbock disease. 61
23824220 2014
25
Avascular necrosis of the lunate bone (Kienböck's disease) secondary to scapholunate ligament tear as a consequence of trauma - a case study. 61
24523832 2014
26
Re: Werber et al. Biomechanical effect of isolated capitate shortening in Kienbock's disease: an anatomical study. J Hand Surg Eur. 2013, 38: 500-7. 61
23974604 2013
27
Radiological and anatomical study to investigate possibility of relationship between scaphoid fracture and lunate morphology. 61
24431268 2013
28
A hand therapy protocol for the treatment of lunate overload or early Kienbock's disease. 61
23465629 2013
29
The association of Kienbock's disease and ulnar variance in the Iranian population. 61
23221184 2013
30
Long-term results after resection arthroplasty in Kienbock's disease. 61
22618553 2013
31
Long-term clinical results and MRI changes after tendon ball arthroplasty for advanced Kienbock's disease. 61
23303835 2013
32
Biomechanical effect of isolated capitate shortening in Kienbock's disease: an anatomical study. 61
22918882 2013
33
The value of delayed MRI scans in the assessment of acute wrist injuries. 61
23926729 2013
34
Bilateral Kienbock's disease concomitant with bilateral Legg-Calvé-Perthes disease: a case report. 61
24426907 2013
35
Kienbock's disease and scapholunate dissociation after acute wrist trauma. 61
24426899 2013
36
Proximal row carpectomy. 61
23168029 2013
37
Kienbock's disease in a varsity football player: a case report and review of the literature. 61
23204571 2012
38
Radial shortening osteotomy in advanced stages of Kienbock disease. 61
23160560 2012
39
Bilateral Kienbock's disease in association with type 1 diabetes. 61
22427280 2012
40
Distal radius osteotomy with intramedullary fixation for the treatment of Kienbock disease. 61
22913997 2012
41
Proximal row carpectomy with capitate osteochondral autograft transplantation. 61
22627929 2012
42
Trabecular microstructure of the human lunate in Kienbock's disease. 61
21965181 2012
43
Kienbock's disease: percutaneous cement lunatoplasty--a cadaver study. 61
22067297 2012
44
Decompression effect of partial capitate shortening for Kienbock's disease: a biomechanical study. 61
23061936 2012
45
Kienbock's Disease treated with Interposition Arthroplasty using Ipsilateral Palmaris Longus Tendon and Muscle Belly. 61
27298845 2012
46
Kienbock's Disease in a Child. 61
23358501 2011
47
Kienbock's disease and juvenile idiopathic arthritis. 61
22363188 2011
48
Arthroscopic core decompression of the lunate in early stage Kienbock disease of the lunate. 61
21358528 2011
49
Double bundle tendon graft for rotational stabilization of lunate implant arthroplasty. 61
21358519 2011
50
A classification-based treatment algorithm for Kienböck disease: current and future considerations. 61
21358524 2011

Variations for Kienbock's Disease

Expression for Kienbock's Disease

Search GEO for disease gene expression data for Kienbock's Disease.

Pathways for Kienbock's Disease

GO Terms for Kienbock's Disease

Sources for Kienbock's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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