MCID: KKC001
MIFTS: 37

Kikuchi Disease

Categories: Rare diseases, Bone diseases, Immune diseases

Aliases & Classifications for Kikuchi Disease

MalaCards integrated aliases for Kikuchi Disease:

Name: Kikuchi Disease 53 59
Histiocytic Necrotizing Lymphadenitis 53 59 73
Kikuchi-Fujimoto Disease 53 59
Histiocytic Necrotising Lymphadenitis 53
Kikuchi Necrotizing Lymphadenitis 53
Nosocomial Kikuchi's Disease 53
Kikuchi-Fujimoto's Disease 53
Kikuchi's Disease 53

Characteristics:

Orphanet epidemiological data:

59
kikuchi-fujimoto disease
Age of onset: Adult;

Classifications:



Summaries for Kikuchi Disease

NIH Rare Diseases : 53 Kikuchi disease is a benign (non-cancerous) condition of the lymph nodes. The main symptoms include swollen lymph nodes in the neck, mild fever, and night sweats. Less common symptoms include weight loss, nausea, vomiting, and sore throat. While the exact cause of this condition is unknown, infectious and autoimmune causes have been suggested. Kikuchi disease usually gets better (resolves) on its own within one to four months (although it may take up to a year), with or without treatment. However, treatments are available to relieve some of the associated signs and symptoms.

MalaCards based summary : Kikuchi Disease, also known as histiocytic necrotizing lymphadenitis, is related to cervicitis and lymphadenitis. An important gene associated with Kikuchi Disease is DDX58 (DExD/H-Box Helicase 58). Affiliated tissues include lymph node, skin and bone, and related phenotypes are oral ulcer and skin rash

Wikipedia : 76 Kikuchi disease or Kikuchi-Fujimoto disease was described in 1972 in Japan. It is also known as... more...

Related Diseases for Kikuchi Disease

Diseases related to Kikuchi Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 cervicitis 10.0
2 lymphadenitis 9.9
3 lupus erythematosus 9.9
4 systemic lupus erythematosus 9.8
5 lymphoma 9.8
6 thyroiditis 9.8
7 lymphosarcoma 9.8
8 hashimoto thyroiditis 9.6
9 myelodysplastic syndrome 9.6
10 arthritis 9.6
11 hemophagocytic lymphohistiocytosis 9.6
12 leukemia 9.6
13 erythema multiforme 9.6
14 aseptic meningitis 9.6
15 hypothyroidism 9.6
16 papillary conjunctivitis 9.6
17 conjunctivitis 9.6
18 follicular adenoma 9.6
19 adenoma 9.6
20 myeloid leukemia 9.6
21 meningitis 9.6
22 macrophage activation syndrome 9.6
23 pasteurella multocida infection 9.6
24 paraneoplastic syndromes 9.6

Graphical network of the top 20 diseases related to Kikuchi Disease:



Diseases related to Kikuchi Disease

Symptoms & Phenotypes for Kikuchi Disease

Human phenotypes related to Kikuchi Disease:

59 32 (show all 44)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 oral ulcer 59 32 frequent (33%) Frequent (79-30%) HP:0000155
2 skin rash 59 32 frequent (33%) Frequent (79-30%) HP:0000988
3 pruritus 59 32 frequent (33%) Frequent (79-30%) HP:0000989
4 cutaneous photosensitivity 59 32 frequent (33%) Frequent (79-30%) HP:0000992
5 alopecia 59 32 frequent (33%) Frequent (79-30%) HP:0001596
6 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
7 leukopenia 59 32 frequent (33%) Frequent (79-30%) HP:0001882
8 anorexia 59 32 frequent (33%) Frequent (79-30%) HP:0002039
9 erythema 59 32 frequent (33%) Frequent (79-30%) HP:0010783
10 low-grade fever 59 32 frequent (33%) Frequent (79-30%) HP:0011134
11 fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012378
12 night sweats 59 32 frequent (33%) Frequent (79-30%) HP:0030166
13 palpebral edema 59 32 frequent (33%) Frequent (79-30%) HP:0100540
14 vasculitis in the skin 59 32 frequent (33%) Frequent (79-30%) HP:0200029
15 skin nodule 59 32 frequent (33%) Frequent (79-30%) HP:0200036
16 abnormality of the neck 59 32 occasional (7.5%) Occasional (29-5%) HP:0000464
17 meningitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001287
18 splenomegaly 59 32 occasional (7.5%) Occasional (29-5%) HP:0001744
19 thrombocytopenia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001873
20 neutropenia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001875
21 anemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001903
22 arthralgia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002829
23 elevated hepatic transaminases 59 32 occasional (7.5%) Occasional (29-5%) HP:0002910
24 myalgia 59 32 occasional (7.5%) Occasional (29-5%) HP:0003326
25 antinuclear antibody positivity 59 32 occasional (7.5%) Occasional (29-5%) HP:0003493
26 elevated erythrocyte sedimentation rate 59 32 occasional (7.5%) Occasional (29-5%) HP:0003565
27 interstitial pulmonary abnormality 59 32 occasional (7.5%) Occasional (29-5%) HP:0006530
28 abnormal blistering of the skin 59 32 occasional (7.5%) Occasional (29-5%) HP:0008066
29 abnormality of the gastrointestinal tract 59 32 occasional (7.5%) Occasional (29-5%) HP:0011024
30 elevated c-reactive protein level 59 32 occasional (7.5%) Occasional (29-5%) HP:0011227
31 enlargement of parotid gland 59 32 occasional (7.5%) Occasional (29-5%) HP:0011801
32 macule 59 32 occasional (7.5%) Occasional (29-5%) HP:0012733
33 lymphocytosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100827
34 papule 59 32 occasional (7.5%) Occasional (29-5%) HP:0200034
35 skin plaque 59 32 occasional (7.5%) Occasional (29-5%) HP:0200035
36 skin erosion 59 32 occasional (7.5%) Occasional (29-5%) HP:0200041
37 ataxia 59 32 very rare (1%) Very rare (<4-1%) HP:0001251
38 pleural effusion 59 32 very rare (1%) Very rare (<4-1%) HP:0002202
39 hepatomegaly 59 32 very rare (1%) Very rare (<4-1%) HP:0002240
40 generalized lymphadenopathy 59 32 very rare (1%) Very rare (<4-1%) HP:0008940
41 myocarditis 59 32 very rare (1%) Very rare (<4-1%) HP:0012819
42 pustule 59 32 very rare (1%) Very rare (<4-1%) HP:0200039
43 lymphadenopathy 59 Frequent (79-30%)
44 abnormality of the lymph nodes 59 Frequent (79-30%)

Drugs & Therapeutics for Kikuchi Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ultrasonographic Differentiation Between Kikuchi's Disease and Lymphoma in Patients With Cervical Lymphadenopathy Unknown status NCT01310933
2 Clinical Studies of Kikuchi's Disease Withdrawn NCT00172445 Not Applicable

Search NIH Clinical Center for Kikuchi Disease

Genetic Tests for Kikuchi Disease

Anatomical Context for Kikuchi Disease

MalaCards organs/tissues related to Kikuchi Disease:

41
Lymph Node, Skin, Bone, Thyroid, Myeloid, Kidney, Spleen

Publications for Kikuchi Disease

Articles related to Kikuchi Disease:

(show top 50) (show all 102)
# Title Authors Year
1
Acoustic radiation force impulse imaging of biopsy-proven Kikuchi disease: initial experiences for evaluating feasibility in pediatric patients. ( 29914233 )
2018
2
Kikuchi's disease (histiocytic necrotizing lymphadenitis): A rare presentation with acute kidney injury, peripheral neuropathy, and aseptic meningitis with cutaneous involvement. ( 29567898 )
2018
3
Association Kikuchi disease with Hashimoto thyroiditis: a case report and literature review. ( 29969882 )
2018
4
Histiocytic Necrotizing Lymphadenitis Involving the Neck: Radiology-Pathology Correlation. ( 29858834 )
2018
5
Expanding the clinical spectrum of self-limiting, rare Kikuchi disease - A case with overwhelming multi-organ involvement. ( 28469047 )
2017
6
CT pattern analysis of necrotizing and nonnecrotizing lymph nodes in Kikuchi disease. ( 28742156 )
2017
7
Aleukemic Myeloid Leukemia Cutis with a Kikuchi Disease-Like Inflammatory Pattern in Myelodysplastic Syndrome. ( 28376531 )
2017
8
Kikuchi Disease ( 28613580 )
2017
9
Histiocytic necrotizing lymphadenitis (Kikuchi's disease) with vasculitis. ( 29178301 )
2017
10
Report of a rare case of histiocytic necrotizing lymphadenitis with bilateral pleural effusion diagnosed via cervical lymph node biopsy. ( 28767989 )
2017
11
Kikuchi Disease. ( 28836904 )
2017
12
Kikuchi Disease with Generalized Lymph Node, Spleen and Subcutaneous Involvement Detected by Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. ( 27277328 )
2016
13
Role of Real-Time Elastography in the Evaluation of Cervical Lymph Nodes in Patients with Kikuchi Disease. ( 27321175 )
2016
14
Clinical Characteristics of Severe Histiocytic Necrotizing Lymphadenitis (Kikuchi-Fujimoto Disease) in Children. ( 26852178 )
2016
15
Sporadic medullary microcarcinoma in a male patient with concurrent Hashimoto's hypothyroidism and Kikuchi disease. ( 26813569 )
2016
16
Dengue viral infection triggering abnormal immune response in a case of Kikuchi disease which later evolved into SLE. ( 27728660 )
2016
17
Kikuchi Disease-Like Inflammatory Pattern in Cutaneous Inflammatory Infiltrates Without Lymph Node Involvement: A New Clue for the Diagnosis of Lupus? ( 26579818 )
2015
18
Comparison of Ultrasonographic Findings of Biopsy-Proven Tuberculous Lymphadenitis and Kikuchi Disease. ( 26175575 )
2015
19
Kikuchi disease. ( 26627522 )
2015
20
Kikuchi disease, macrophage activation syndrome, and systemic juvenile arthritis: a new case associated with a mutation in the perforin gene. ( 25974073 )
2015
21
Kikuchi Disease Mimicking Metastatic Lymphadenopathy on (18)F-FDG PET/CT in Patients with Breast Cancer. ( 26082813 )
2015
22
Kikuchi disease presenting with aseptic meningitis. ( 24746858 )
2014
23
Real-time elastography of cervical lymph nodes in Kikuchi disease. ( 25425380 )
2014
24
Kikuchi disease in connecticut. ( 24112859 )
2014
25
Causative agents of Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis): A meta-analysis. ( 25200851 )
2014
26
Histiocytic necrotizing lymphadenitis diagnosed by conventional cytology and liquid based cytology. ( 25337268 )
2014
27
Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) preceding tuberculous pleurisy. ( 24576282 )
2014
28
Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) with CNS involvement in a child. ( 24091923 )
2013
29
A non-invasive diagnosis of histiocytic necrotizing lymphadenitis by means of gene expression profile analysis of peripheral blood mononuclear cells. ( 23609111 )
2013
30
Cutting needle biopsy combined with immunohistochemical study of myeloperoxidase for the diagnosis of histiocytic necrotizing lymphadenitis. ( 24245703 )
2013
31
Recurrent histiocytic necrotizing lymphadenitis with a long latency in a patient with autoimmunity: a case report and review of literature. ( 23204033 )
2013
32
18F-FDG PET/CT findings in patients with Kikuchi disease. ( 23681151 )
2013
33
Features of sequential CT and US-guided biopsy in recurrent Kikuchi disease of the neck: a case report. ( 24057904 )
2013
34
Cutaneous Kikuchi disease-like eruption presenting as a paraneoplastic syndrome. ( 22340699 )
2012
35
Kikuchi disease: differentiation from tuberculous lymphadenitis based on patterns of nodal necrosis on CT. ( 22173774 )
2012
36
Kikuchi-Fujimoto disease, histiocytic necrotizing lymphadenitis. ( 22485246 )
2012
37
Kikuchi Fujimoto disease (histiocytic necrotizing lymphadenitis) following Hodgkin lymphoma. ( 22827768 )
2012
38
Expression of Epstein-Barr virus and granzyme B in cytologic smears of histiocytic necrotizing lymphadenitis. ( 21319329 )
2012
39
Kikuchi disease with skin lesions mimicking lupus erythematosus. ( 23091585 )
2012
40
Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) after laparoscopic Roux-en-Y gastric bypass for morbid obesity: a case report. ( 23043774 )
2012
41
Autoimmune manifestations of Kikuchi disease. ( 22192931 )
2012
42
Disseminated Kikuchi disease associated with hemophagocytic syndrome in an infant: whole-body MRI. ( 21069584 )
2011
43
Kikuchi-Fujimoto disease. Histiocytic necrotizing lymphadenitis. ( 22057597 )
2011
44
MR imaging findings of cervical lymphadenopathy in patients with Kikuchi disease. ( 21993181 )
2011
45
Gray scale and power Doppler study of biopsy-proven Kikuchi disease. ( 21705728 )
2011
46
Pathology quiz case 1. Kikuchi disease. ( 21422320 )
2011
47
Lymph node uptake of 18F-fluorodeoxyglucose detected with positron emission tomography/computed tomography mimicking malignant lymphoma in a patient with Kikuchi disease. ( 21156466 )
2010
48
Kikuchi disease in a child. ( 20666073 )
2010
49
Kikuchi disease in association with Pasteurella multocida infection. ( 20123771 )
2010
50
Cytologic features and frequency of plasmacytoid dendritic cells in the lymph nodes of patients with histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease). ( 19941366 )
2010

Variations for Kikuchi Disease

Expression for Kikuchi Disease

Search GEO for disease gene expression data for Kikuchi Disease.

Pathways for Kikuchi Disease

GO Terms for Kikuchi Disease

Sources for Kikuchi Disease

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74 UMLS via Orphanet
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