MCID: KKC001
MIFTS: 35

Kikuchi Disease

Categories: Bone diseases, Immune diseases, Rare diseases

Aliases & Classifications for Kikuchi Disease

MalaCards integrated aliases for Kikuchi Disease:

Name: Kikuchi Disease 20 58
Histiocytic Necrotizing Lymphadenitis 20 58 70
Kikuchi-Fujimoto Disease 20 58
Histiocytic Necrotising Lymphadenitis 20
Kikuchi Necrotizing Lymphadenitis 20
Nosocomial Kikuchi's Disease 20
Kikuchi-Fujimoto's Disease 20
Kikuchi's Disease 20

Characteristics:

Orphanet epidemiological data:

58
kikuchi-fujimoto disease
Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases


Summaries for Kikuchi Disease

GARD : 20 Kikuchi disease is a benign (non-cancerous) condition of the lymph nodes. The main symptoms include swollen lymph nodes in the neck, mild fever, and night sweats. Less common symptoms include weight loss, nausea, vomiting, and sore throat. While the exact cause of this condition is unknown, infectious and autoimmune causes have been suggested. Kikuchi disease usually gets better (resolves) on its own within one to four months (although it may take up to a year), with or without treatment. However, treatments are available to relieve some of the associated signs and symptoms.

MalaCards based summary : Kikuchi Disease, also known as histiocytic necrotizing lymphadenitis, is related to lymphadenitis and lymphoma, non-hodgkin, familial. Affiliated tissues include lymph node, t cells and bone marrow, and related phenotypes are cervical lymphadenopathy and fatigue

Wikipedia : 73 Kikuchi disease was described in 1972 in Japan. It is also known as histiocytic necrotizing... more...

Related Diseases for Kikuchi Disease

Diseases related to Kikuchi Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 229)
# Related Disease Score Top Affiliating Genes
1 lymphadenitis 10.6
2 lymphoma, non-hodgkin, familial 10.5
3 disease by infectious agent 10.5
4 sarcoidosis 1 10.3
5 diarrhea 10.3
6 thyroid carcinoma 10.3
7 lymphoma, hodgkin, classic 10.3
8 b-cell lymphoma 10.3
9 sickle cell anemia 10.2
10 c1q deficiency 10.2
11 covid-19 10.2
12 human cytomegalovirus infection 10.2
13 brucellosis 10.2
14 panuveitis 10.2
15 optic neuritis 10.2
16 pericarditis 10.2
17 skin disease 10.2
18 pneumonia 10.2
19 pyomyositis 10.2
20 rubella 10.2
21 intracranial hypertension 10.2
22 raynaud phenomenon 10.2
23 lupus erythematosus panniculitis 10.2
24 thrombocytopenia 10.2
25 antiphospholipid syndrome 10.2
26 histiocytosis 10.2
27 lymph node tuberculosis 10.2
28 herpes simplex 10.2
29 granulocytopenia 10.2
30 posttransplant acute limbic encephalitis 10.2
31 autoimmune hepatitis 10.1
32 dermatitis 10.1
33 tremor 10.1
34 systemic lupus erythematosus 10.1
35 exanthem 10.1
36 lupus erythematosus 10.1
37 juvenile rheumatoid arthritis 10.1
38 thymoma, familial 10.1
39 lymphoma 10.1
40 thymoma 10.1
41 meningoencephalitis 10.1
42 headache 10.1
43 breast cancer 10.1
44 thrombocytopenic purpura, autoimmune 10.1
45 thrombophilia due to thrombin defect 10.1
46 thyroid cancer, nonmedullary, 1 10.1
47 anemia, autoimmune hemolytic 10.1
48 celiac disease 1 10.1
49 myasthenia gravis 10.1
50 vexas syndrome 10.1

Graphical network of the top 20 diseases related to Kikuchi Disease:



Diseases related to Kikuchi Disease

Symptoms & Phenotypes for Kikuchi Disease

Human phenotypes related to Kikuchi Disease:

58 31 (show top 50) (show all 52)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 cervical lymphadenopathy 58 31 hallmark (90%) Very frequent (99-80%) HP:0025289
2 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
3 alopecia 58 31 frequent (33%) Frequent (79-30%) HP:0001596
4 palpebral edema 58 31 frequent (33%) Frequent (79-30%) HP:0100540
5 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
6 erythema 58 31 frequent (33%) Frequent (79-30%) HP:0010783
7 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
8 cutaneous photosensitivity 58 31 frequent (33%) Frequent (79-30%) HP:0000992
9 pruritus 58 31 frequent (33%) Frequent (79-30%) HP:0000989
10 leukopenia 58 31 frequent (33%) Frequent (79-30%) HP:0001882
11 oral ulcer 58 31 frequent (33%) Frequent (79-30%) HP:0000155
12 low-grade fever 58 31 frequent (33%) Frequent (79-30%) HP:0011134
13 skin nodule 58 31 frequent (33%) Frequent (79-30%) HP:0200036
14 night sweats 58 31 frequent (33%) Frequent (79-30%) HP:0030166
15 vasculitis in the skin 58 31 frequent (33%) Frequent (79-30%) HP:0200029
16 chills 58 31 frequent (33%) Frequent (79-30%) HP:0025143
17 malar rash 58 31 frequent (33%) Frequent (79-30%) HP:0025300
18 increased lactate dehydrogenase level 31 frequent (33%) HP:0025435
19 splenomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0001744
20 anemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001903
21 elevated hepatic transaminase 58 31 occasional (7.5%) Occasional (29-5%) HP:0002910
22 thrombocytopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001873
23 arthralgia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002829
24 myalgia 58 31 occasional (7.5%) Occasional (29-5%) HP:0003326
25 abnormality of the neck 58 31 occasional (7.5%) Occasional (29-5%) HP:0000464
26 meningitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001287
27 neutropenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001875
28 abnormality of the gastrointestinal tract 58 31 occasional (7.5%) Occasional (29-5%) HP:0011024
29 papule 58 31 occasional (7.5%) Occasional (29-5%) HP:0200034
30 abnormal blistering of the skin 58 31 occasional (7.5%) Occasional (29-5%) HP:0008066
31 skin erosion 58 31 occasional (7.5%) Occasional (29-5%) HP:0200041
32 elevated c-reactive protein level 58 31 occasional (7.5%) Occasional (29-5%) HP:0011227
33 elevated erythrocyte sedimentation rate 58 31 occasional (7.5%) Occasional (29-5%) HP:0003565
34 skin plaque 58 31 occasional (7.5%) Occasional (29-5%) HP:0200035
35 lymphocytosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100827
36 antinuclear antibody positivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0003493
37 erythematous macule 58 31 occasional (7.5%) Occasional (29-5%) HP:0025475
38 enlargement of parotid gland 58 31 occasional (7.5%) Occasional (29-5%) HP:0011801
39 abnormal pulmonary interstitial morphology 31 occasional (7.5%) HP:0006530
40 ataxia 58 31 very rare (1%) Very rare (<4-1%) HP:0001251
41 hepatomegaly 58 31 very rare (1%) Very rare (<4-1%) HP:0002240
42 myocarditis 58 31 very rare (1%) Very rare (<4-1%) HP:0012819
43 pleural effusion 58 31 very rare (1%) Very rare (<4-1%) HP:0002202
44 pustule 58 31 very rare (1%) Very rare (<4-1%) HP:0200039
45 generalized lymphadenopathy 58 31 very rare (1%) Very rare (<4-1%) HP:0008940
46 macule 58 Occasional (29-5%)
47 skin rash 58 Frequent (79-30%)
48 vasculitis 58 Frequent (79-30%)
49 lymphadenopathy 58 Frequent (79-30%)
50 interstitial pulmonary abnormality 58 Occasional (29-5%)

Drugs & Therapeutics for Kikuchi Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ultrasonographic Differentiation Between Kikuchi's Disease and Lymphoma in Patients With Cervical Lymphadenopathy Unknown status NCT01310933
2 Clinical Studies of Kikuchi's Disease Withdrawn NCT00172445

Search NIH Clinical Center for Kikuchi Disease

Genetic Tests for Kikuchi Disease

Anatomical Context for Kikuchi Disease

MalaCards organs/tissues related to Kikuchi Disease:

40
Lymph Node, T Cells, Bone Marrow, Spleen, Salivary Gland, Myeloid, Monocytes

Publications for Kikuchi Disease

Articles related to Kikuchi Disease:

(show top 50) (show all 479)
# Title Authors PMID Year
1
Kikuchi disease with cutaneous involvement complicated by features of hemophagocytic lymphohistiocytosis. 61
33470433 2021
2
Cutaneous Kikuchi disease-like inflammatory pattern without lymph node involvement is associated with systemic disease and severe features in lupus erythematous: A case-control study. 61
33292039 2021
3
Distinguishing lupus lymphadenitis from Kikuchi disease based on clinicopathological features and C4d immunohistochemistry. 61
33169134 2021
4
Hemophagocytic Lymphohistiocytosis Associated with Histiocytic Necrotizing Lymphadenitis: A Clinical Study of 13 Children and Literature Review. 61
32956695 2021
5
Kikuchi Disease with enlargement of intramammary lymph node. 61
33343778 2021
6
Baffled with fever and lymphadenopathy: neither infection nor malignancy, think Kikuchi disease. 61
33509881 2021
7
Causes of necrotic features in fine-needle aspirates from cervical lymph nodes. 61
33238663 2021
8
Methotrexate-associated lymphoproliferative disorder with histopathological features of histiocytic necrotizing lymphadenitis. 61
33269654 2021
9
Recurrent Aseptic Meningitis Associated with Kikuchi's Disease (Histiocytic Necrotizing Lymphadenitis): A Case Report and Literature Review. 61
33431735 2021
10
Kikuchi Disease: A Case Report. 61
32921539 2020
11
Kikuchi Cervical Lymphadenitis in Children: Ultrasound Differentiation From Common Infectious Lymphadenitis. 61
33263358 2020
12
Recurrent Kikuchi-Fujimoto Disease Masquerading as Lymphoma Successfully Treated by Anakinra. 61
33391894 2020
13
Hemophagocytic lymphohistiocytosis with recurrent Kikuchi-Fujimoto disease. 61
33171575 2020
14
A Mimic of Posttransplant Lymphoproliferative Disease Following Liver Transplant. 61
29108510 2020
15
Usefulness of ultrasonography for diagnosing iatrogenic spinal accessory nerve palsy after lymph node needle biopsy: a case report. 61
33129299 2020
16
A clinical scoring approach for detection of histiocytic necrotizing lymphadenitis in adults. 61
32896970 2020
17
Kikuchi-Fujimoto disease preceded by lupus erythematosus panniculitis: do these findings together herald the onset of systemic lupus erythematosus? 61
32941714 2020
18
A Case of Kikuchi-Fujimoto Disease in a 7-Year-Old African American Patient: A Case Report and Review of Literature. 61
32830793 2020
19
Cervical lymphadenopathy in children: a diagnostic tree analysis model based on ultrasonographic and clinical findings. 61
32189052 2020
20
Kikuchi disease as a possible cause of ischaemic stroke: a case report. 61
32351150 2020
21
[One case of histiocytic necrotizing lymphadenitis with severe thrombocytopenia]. 61
32209200 2020
22
[Efficacy of medicinal penetration on acupoint as adjunctive therapy on histiocytic necrotizing lymphadenitis of heat-toxin syndrome: a randomized controlled trial]. 61
32275363 2020
23
Strong association of Torque teno virus/Torque teno-like minivirus to Kikuchi-Fujimoto lymphadenitis (histiocytic necrotizing lymphadenitis) on quantitative analysis. 61
31782015 2020
24
A Case of Kikuchi-Fujimoto Disease Associated with Erosive Lichen Planus. 61
32313753 2020
25
Identification of Torque Teno Virus/Torque Teno-Like Minivirus in the Cervical Lymph Nodes of Kikuchi-Fujimoto Lymphadenitis Patients (Histiocytic Necrotizing Lymphadenitis): A Possible Key to Idiopathic Disease. 61
32775328 2020
26
Kikuchi-Fujimoto Disease: Review of 11 Cases Diagnosed Over 10 Years at a Tertiary Care Hospital in Doha, Qatar. 61
32523919 2020
27
Risk Assessment of Recurrence and Autoimmune Disorders in Kikuchi Disease. 61
33061702 2020
28
Kikuchi-Fujimoto Disease-Like Inflammatory Reaction in a Silicone Breast Implant Seroma. 61
31962314 2020
29
Histiocytic Necrotizing Lymphadenitis Involving the Neck: Radiology-Pathology Correlation. 61
29858834 2019
30
Differentiation Between Malignant and Benign Lymph Nodes: Role of Superb Microvascular Imaging in the Evaluation of Cervical Lymph Nodes. 61
30945325 2019
31
Cervical necrotic lymphadenopathy: a diagnostic tree analysis model based on CT and clinical findings. 61
30915564 2019
32
Extra-nodal Kikuchi Disease and Kikuchi Encephalitis. 61
31724549 2019
33
Phenytoin-associated necrotising lymphadenitis mimicking Kikuchi disease. 61
31466864 2019
34
Kikuchi-Fujimoto Disease in Children: An Important Diagnostic Consideration for Cervical Lymphadenitis. 61
31610000 2019
35
Kikuchi-Fujimoto disease: a case report and the evaluation of diagnostic procedures. 61
31638953 2019
36
Distribution of lymphadenopathy in patients with Kikuchi disease. 61
31615722 2019
37
Comparison of clinical and pathological features of lymph node tuberculosis and histiocytic necrotizing lymphadenitis. 61
32069254 2019
38
Kikuchi Disease: A Rare Cause of Aseptic Meningitis. 61
31512656 2019
39
Kikuchi-Fujimoto disease associated with systemic lupus erythematosus complicated with hemophagocytic lymphohistiocytosis: a case report. 61
31167644 2019
40
Histopathology and expression of the chemokines CXCL10, CXCL13, and CXCR3 and the endogenous TLR-4 ligand S100A8/A9 in lymph nodes of patients with adult-onset Still's disease. 61
31101882 2019
41
Cutaneous lupus with Kikuchi disease-like inflammatory pattern associated with myelodysplastic syndrome. 61
30590766 2019
42
Rare diseases that mimic Systemic Lupus Erythematosus (Lupus mimickers). 61
30837156 2019
43
Is recurrent Kikuchi-Fujimoto disease a precursor to systemic lupus erythematosus? 61
30375354 2019
44
A rare presentation of Kikuchi Disease with Hemolytic Uremic Syndrome. 61
31086556 2019
45
Kikuchi-Fujimoto Disease in Michigan: A Rare Case Report and Review of the Literature. 61
30833818 2019
46
Relapsing Kikuchi-Fujimoto Disease Requiring Prolonged Steroid Therapy. 61
30984430 2019
47
Kikuchi-Fujimoto Disease in an Iranian Woman; a Rare but Important Cause of Lymphadenopathy. 61
30847438 2019
48
Acoustic radiation force impulse imaging of biopsy-proven Kikuchi disease: initial experiences for evaluating feasibility in pediatric patients. 61
29914233 2019
49
Kikuchi disease: an unusual case with features suggesting an infectious aetiology. 61
30145070 2018
50
Report of a rare case of histiocytic necrotizing lymphadenitis with bilateral pleural effusion diagnosed via cervical lymph node biopsy. 61
28767989 2018

Variations for Kikuchi Disease

Expression for Kikuchi Disease

Search GEO for disease gene expression data for Kikuchi Disease.

Pathways for Kikuchi Disease

GO Terms for Kikuchi Disease

Sources for Kikuchi Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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