MCID: KMR001
MIFTS: 46

Kimura Disease

Categories: Bone diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Kimura Disease

MalaCards integrated aliases for Kimura Disease:

Name: Kimura Disease 12 77 54 60 56 15 17 74
Eosinophilic Lymphogranuloma 54 60
Eosinophilic Hyperplastic Lymphogranuloma 54
Eosinophilic Lymphofollicular Granuloma 54
Eosinophilic Granuloma of Soft Tissue 54
Eosinophilic Lymphofolliculosis 54
Kimura's Disease 12

Characteristics:

Orphanet epidemiological data:

60
kimura disease
Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:7365
MeSH 45 D000796
NCIt 51 C26867
SNOMED-CT 69 69484003
MESH via Orphanet 46 D000796
ICD10 via Orphanet 35 I89.8
UMLS via Orphanet 75 C0033838
Orphanet 60 ORPHA482
SNOMED-CT via HPO 70 10890000
UMLS 74 C0033838

Summaries for Kimura Disease

NIH Rare Diseases : 54 Kimura disease is a rare, noncancerous, chronic condition that causes the tissue under the skin of the head or neck to become swollen. Masses generally appear in a person's mid-20s and the disease mainly affects Asian men. Kimura disease is diagnosed by a surgical biopsy and the cause of the disease is unknown. Treatment includes surgery, medication, or a combination of the two.  However, the masses tend to develop again after treatment. Because this condition rarely causes health problems, people with Kimura disease have a good outcome.

MalaCards based summary : Kimura Disease, also known as eosinophilic lymphogranuloma, is related to hypereosinophilic syndrome and asthma. An important gene associated with Kimura Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. Affiliated tissues include skin, lymph node and salivary gland, and related phenotypes are eosinophilia and follicular hyperplasia

Wikipedia : 77 Kimura''s disease is a benign rare chronic inflammatory disorder. Its primary symptoms are subdermal... more...

Related Diseases for Kimura Disease

Diseases related to Kimura Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 hypereosinophilic syndrome 30.1 CCL11 IL4 IL5 RNASE3
2 asthma 27.8 CCL11 CCL5 CCR3 IL4 IL5 RNASE3
3 nephrotic syndrome 10.4
4 loeffler endocarditis 10.3 IL5 RNASE3
5 paragonimiasis 10.3 IL5 RNASE3
6 cow milk allergy 10.3 IL5 RNASE3
7 contact dermatitis 10.3 IL4 IL5
8 sinusitis 10.3 IL5 RNASE3
9 nickel allergic contact dermatitis 10.3 IL4 IL5
10 scleritis 10.3 IL4 IL5
11 egg allergy 10.3 IL4 IL5
12 sulfamethoxazole allergy 10.3 IL4 IL5
13 trichinosis 10.3 IL4 IL5
14 apple allergy 10.2 IL4 IL5
15 pemphigoid gestationis 10.2 CCL11 IL5
16 gaucher disease, type ii 10.2 IL4 IL5
17 non-suppurative otitis media 10.2 IL4 IL5
18 chronic meningitis 10.2 CCL11 IL5
19 pollen allergy 10.2 IL5 RNASE3
20 papillary conjunctivitis 10.2 CCL11 IL4
21 intestinal schistosomiasis 10.2 IL4 IL5
22 chronic tic disorder 10.2 IL4 IL5
23 filarial elephantiasis 10.2 IL4 IL5
24 toxic oil syndrome 10.2 IL4 IL5
25 strongyloidiasis 10.2 CCL11 IL5
26 enterobiasis 10.2 IL4 IL5
27 wells syndrome 10.2 IL5 RNASE3
28 respiratory syncytial virus infectious disease 10.2 CCL5 IL5
29 allergic bronchopulmonary aspergillosis 10.2 IL4 IL5
30 skin epithelioid hemangioma 10.2
31 histiocytoid hemangioma 10.2
32 aspergillosis 10.2 IL4 IL5
33 radiculopathy 10.2 CCL11 IL5
34 churg-strauss syndrome 10.2 IL5 RNASE3
35 maxillary sinusitis 10.2 CCL5 RNASE3
36 paranasal sinus disease 10.2 IL4 IL5
37 vernal conjunctivitis 10.2 IL4 RNASE3
38 night blindness, congenital stationary, type 1a 10.2 CCL11 IL5
39 cellulitis 10.2 IL5 RNASE3
40 inclusion conjunctivitis 10.1 CCL5 IL5
41 vulvovaginitis 10.1 CCL11 CCL5
42 ocular cicatricial pemphigoid 10.1 IL4 RNASE3
43 paracoccidioidomycosis 10.1 IL4 IL5
44 eosinophilic granuloma 10.1
45 genital herpes 10.1 CCL5 IL4
46 bullous skin disease 10.1 CCL5 IL5
47 cough variant asthma 10.1 IL4 IL5 RNASE3
48 inflammatory bowel disease 4 10.1 IL4 IL5 RNASE3
49 atopic keratoconjunctivitis 10.1 IL4 IL5 RNASE3
50 intrinsic asthma 10.1 IL4 IL5 RNASE3

Graphical network of the top 20 diseases related to Kimura Disease:



Diseases related to Kimura Disease

Symptoms & Phenotypes for Kimura Disease

Human phenotypes related to Kimura Disease:

60 33 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 eosinophilia 60 33 hallmark (90%) Very frequent (99-80%) HP:0001880
2 follicular hyperplasia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002729
3 increased circulating total ige level 33 hallmark (90%) HP:0003212
4 abnormal salivary gland morphology 33 occasional (7.5%) HP:0010286
5 lymphadenopathy 60 Frequent (79-30%)
6 increased ige level 60 Very frequent (99-80%)
7 abnormality of the salivary glands 60 Occasional (29-5%)

MGI Mouse Phenotypes related to Kimura Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CCL11 CCL5 CCR3 IL33 IL4 IL5
2 immune system MP:0005387 9.5 CCL11 CCL5 CCR3 IL33 IL4 IL5
3 respiratory system MP:0005388 9.1 CCL11 CCR3 IL33 IL4 IL5 TSLP

Drugs & Therapeutics for Kimura Disease

Search Clinical Trials , NIH Clinical Center for Kimura Disease

Genetic Tests for Kimura Disease

Anatomical Context for Kimura Disease

MalaCards organs/tissues related to Kimura Disease:

42
Skin, Lymph Node, Salivary Gland, Kidney, Bone, Brain, Colon

Publications for Kimura Disease

Articles related to Kimura Disease:

(show top 50) (show all 115)
# Title Authors Year
1
Angiolymphoid hyperplasia with eosinophilia and Kimura disease overlap, with evidence of diffuse visceral involvement. ( 30362278 )
2019
2
An unexpected asymptomatic epiglottal site of Kimura disease. ( 30712651 )
2019
3
Kimura disease: a case report of a rare illness presenting as a common complaint. ( 30808157 )
2019
4
Kimura disease: case report and brief review of literature. ( 31086850 )
2019
5
Orbital Mass With Features of Both Kimura Disease and Immunoglobulin G4-Related Disease. ( 29923967 )
2018
6
Computerized tomography features and clinicopathological analysis of Kimura disease in head and neck. ( 30186444 )
2018
7
Kimura Disease: A differential diagnosis in a nephrotic child. ( 30302182 )
2018
8
A rare case of inguinal kimura disease. ( 30350814 )
2018
9
Kimura disease and Immunoglobulin G4-related disease - possible overlap in a patient with severe systemic symptoms. ( 30543201 )
2018
10
Successful therapy with mycophenolic acid in a membranous glomerulonephritis due to Kimura disease
. ( 28853699 )
2017
11
Recurrent Kimura Disease of the Inner Canthus With No Lymphadenopathy. ( 26020715 )
2017
12
Expression of the interleukin-21 and phosphorylated extracellular signal regulated kinase 1/2 in Kimura disease. ( 28108473 )
2017
13
Superficial Parotidectomy Plane for Debulking Surgery in Kimura Disease. ( 28468187 )
2017
14
Treatment of Kimura disease with mycophenolate mofetil monotherapy. ( 28932783 )
2017
15
A Rare Case of Kimura Disease with Bilateral Parotid Involvement. ( 28946727 )
2017
16
Basophils are increased and express increased levels of interleukin-4 in the parotid lesions of Kimura disease. ( 29094020 )
2017
17
Kimura Disease: A Rare Case Report From Himalayan Region. ( 29238694 )
2017
18
Nephrotic syndrome during the tapering of oral steroids after pathological diagnosis of Kimura disease from a lacrimal gland mass: case report and review of 10 Japanese patients. ( 29279552 )
2017
19
Kimura disease of buccal region in a pediatric patient with nephrotic syndrome: A case report. ( 29310412 )
2017
20
Kimura disease. ( 29469792 )
2017
21
Detailed Imaging Findings in a Rare Case of Kimura Disease, with Special Mention on Diffusion Weighted Imaging. ( 29657623 )
2017
22
A case of refractory Kimura disease with a buccal bulky mass successfully treated with low-dose cyclosporine A: report and review of the literature. ( 26666475 )
2016
23
Comparison of Local Recurrence Rate of Three Treatment Modalities for Kimura Disease. ( 26674917 )
2016
24
Kimura disease: No age or ethnicity limit. ( 26905356 )
2016
25
Human Polyomavirus-6 Infecting Lymph Nodes of a Patient With an Angiolymphoid Hyperplasia With Eosinophilia or Kimura Disease. ( 26962076 )
2016
26
Kimura Disease of the Breast - A Previously Undescribed Entity. ( 27058987 )
2016
27
An Unusual Clinical Presentation of Kimura Disease Manifesting with a Typical Cephalocervical Lesion and an Atypical Subcutaneous Hip Mass Lesion. ( 27086824 )
2016
28
Kimura Disease Presenting as Forehead Soft Mass. ( 27100647 )
2016
29
Eosinophilia and multiple lymphadenopathy: Kimura disease, a rare, but benign condition. ( 27581232 )
2016
30
Concurrent Kimura disease and lupus nephritis: A case report. ( 27741124 )
2016
31
Kimura disease in a Maori man with nephrotic syndrome. ( 27981775 )
2016
32
Retrospective Multicentric Study of 25 Kimura Disease Patients: Emphasis on Therapeutics and Shared Features with Cutaneous IgG4-Related Disease. ( 26452023 )
2015
33
Paradoxical brain embolism associated with Kimura disease mimics watershed infarction. ( 25447210 )
2015
34
A mass under parotid gland: a patient with Kimura disease. ( 25668110 )
2015
35
Pulmonary embolism as the initial clinical presentation of Kimura disease: case report and literature review. ( 25699606 )
2015
36
Kimura disease accompanied with nephrotic syndrome in a 45-year-old male. ( 25928198 )
2015
37
Kimura disease associated with severe visual dysfunction due to remarkable periorbital involvement. ( 26031497 )
2015
38
Kimura Disease Presenting As an Eyelid Mass in a Young Asian Male. ( 26080258 )
2015
39
Kimura Disease Mimicking an Aneurysm of the Radial Artery. ( 26362092 )
2015
40
Unusual Cause of Swelling in the Upper Limb: Kimura Disease. ( 26421119 )
2015
41
Kimura disease: A rare case of bilateral infra-auricular masses. ( 26831431 )
2015
42
Kimura disease of the epiglottis: a case report and review of literature. ( 23907346 )
2014
43
Kimura disease: rare cause of a slowly progressive orbital mass. ( 24119195 )
2014
44
Kimura disease complicated with bowel infarction and multiple arterial thromboses in the extremities. ( 24356478 )
2014
45
Kimura disease associated with IgA nephropathy. ( 24656163 )
2014
46
Preliminary study of diffusion-weighted imaging and magnetic resonance spectroscopy imaging in Kimura disease. ( 25377973 )
2014
47
Kimura disease manifesting as synchronous bilateral parotid swelling in a young middle-eastern patient. ( 25544928 )
2014
48
Kimura Disease Simulating Hodgkin's Lymphoma on (18)F FDG PET-CT: Report of a Case. ( 26396638 )
2014
49
Remission of secondary membranous nephropathy in a patient with Kimura disease after surgical resection. ( 26877967 )
2014
50
Intraparotid Kimura disease. ( 23021002 )
2013

Variations for Kimura Disease

Expression for Kimura Disease

Search GEO for disease gene expression data for Kimura Disease.

Pathways for Kimura Disease

Pathways related to Kimura Disease according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CCL11 CCL5 CCR3 IL33 IL4 IL5
2
Show member pathways
13.1 CCL11 CCL5 CCR3 IL4 IL5
3
Show member pathways
13.04 CCL11 CCL5 IL33 IL4 IL5
4
Show member pathways
12.97 CCL11 CCL5 CCR3 IL4 IL5
5
Show member pathways
12.59 CCL11 IL4 IL5 RNASE3
6
Show member pathways
12.15 IL4 IL5 TSLP
7
Show member pathways
12.1 CCL11 CCL5 CCR3
8
Show member pathways
12.08 CCL11 IL4 IL5
9
Show member pathways
11.77 CCL11 CCL5 IL4 IL5
10
Show member pathways
11.74 CCL11 CCL5 CCR3
11 11.72 CCR3 IL4 IL5
12 11.46 CCL11 CCL5 IL4
13 11.46 IL33 IL4 IL5 TSLP
14 11.38 CCL11 IL4 IL5
15 11.31 CCL5 IL4
16 11.28 CCL11 TSLP
17 11.12 IL4 IL5
18 11.12 CCL11 IL33 IL4 IL5
19 11.05 IL4 IL5
20 10.98 IL4 IL5
21 10.85 CCL11 CCL5 IL4 IL5
22 10.82 CCL11 CCL5 CCR3 IL4 IL5
23 10.76 IL33 IL4 IL5 TSLP
24 10.73 CCL11 CCL5 IL4 IL5

GO Terms for Kimura Disease

Cellular components related to Kimura Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 CCL5 IL33 IL4 IL5 RNASE3
2 extracellular space GO:0005615 9.17 CCL11 CCL5 IL33 IL4 IL5 RNASE3

Biological processes related to Kimura Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.73 CCL11 CCL5 CCR3 IL5
2 chemotaxis GO:0006935 9.65 CCL11 CCL5 CCR3
3 positive regulation of T cell proliferation GO:0042102 9.57 CCL5 IL4
4 positive regulation of interleukin-6 production GO:0032755 9.56 IL33 TSLP
5 cytokine-mediated signaling pathway GO:0019221 9.56 CCL11 CCL5 IL4 IL5
6 monocyte chemotaxis GO:0002548 9.55 CCL11 CCL5
7 immune response GO:0006955 9.55 CCL11 CCL5 CCR3 IL4 IL5
8 positive regulation of B cell proliferation GO:0030890 9.54 IL4 IL5
9 chemokine-mediated signaling pathway GO:0070098 9.54 CCL11 CCL5 CCR3
10 lymphocyte chemotaxis GO:0048247 9.52 CCL11 CCL5
11 positive regulation of JAK-STAT cascade GO:0046427 9.51 CCL5 IL5
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.5 CCL5 IL4 TSLP
13 eosinophil chemotaxis GO:0048245 9.49 CCL11 CCL5
14 positive regulation of immunoglobulin secretion GO:0051024 9.46 IL33 IL5
15 positive regulation of interleukin-5 production GO:0032754 9.4 IL33 TSLP
16 positive regulation of interleukin-13 production GO:0032736 9.13 IL33 IL4 TSLP
17 regulation of signaling receptor activity GO:0010469 9.1 CCL11 CCL5 IL33 IL4 IL5 TSLP

Molecular functions related to Kimura Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.16 CCL11 CCL5
2 cytokine activity GO:0005125 9.1 CCL11 CCL5 IL33 IL4 IL5 TSLP
3 CCR chemokine receptor binding GO:0048020 8.96 CCL11 CCL5

Sources for Kimura Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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