Kimura Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: KMR001 MIFTS: 43	Kimura Disease Categories: Bone diseases, Immune diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Kimura Disease

MalaCards integrated aliases for Kimura Disease:

Name: Kimura Disease ¹² ⁷⁴ ⁵² ⁵⁸ ⁵⁴ ¹⁵ ¹⁷ ⁷¹

Eosinophilic Lymphogranuloma ⁵² ⁵⁸

Eosinophilic Hyperplastic Lymphogranuloma ⁵²

Eosinophilic Lymphofollicular Granuloma ⁵²

Eosinophilic Granuloma of Soft Tissue ⁵²

Eosinophilic Lymphofolliculosis ⁵²

Kimura's Disease ¹²

Characteristics:

Orphanet epidemiological data:

⁵⁸

kimura disease
Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases Skin diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the circulatory system

Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified

Other noninfective disorders of lymphatic vessels and lymph nodes

Other specified noninfective disorders of lymphatic vessels and lymph nodes

Orphanet: ⁵⁸

Rare systemic and rhumatological diseases

External Ids:

Disease Ontology ¹² DOID:7365

MeSH ⁴³ D000796

NCIt ⁴⁹ C26867

SNOMED-CT ⁶⁷ 69484003

MESH via Orphanet ⁴⁴ D000796

ICD10 via Orphanet ³³ I89.8

UMLS via Orphanet ⁷² C0033838

Orphanet ⁵⁸ ORPHA482

SNOMED-CT via HPO ⁶⁸ 10890000

EFO ¹⁷ EFO_1000722

UMLS ⁷¹ C0033838

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Summaries for Kimura Disease

NIH Rare Diseases : ⁵² Kimura disease is a rare, noncancerous, chronic condition that causes the tissue under the skin of the head or neck to become swollen. Masses generally appear in a person's mid-20s and the disease mainly affects Asian men. Kimura disease is diagnosed by a surgical biopsy and the cause of the disease is unknown. Treatment includes surgery, medication, or a combination of the two. However, the masses tend to develop again after treatment. Because this condition rarely causes health problems, people with Kimura disease have a good outcome.

MalaCards based summary : Kimura Disease, also known as eosinophilic lymphogranuloma, is related to disseminated eosinophilic collagen disease and scabies. An important gene associated with Kimura Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include lymph node, skin and salivary gland, and related phenotypes are eosinophilia and follicular hyperplasia

Wikipedia : ⁷⁴ Kimura's disease is a benign rare chronic inflammatory disorder. Its primary symptoms are subdermal... more...

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Related Diseases for Kimura Disease

Diseases related to Kimura Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 276)

#	Related Disease	Score	Top Affiliating Genes
1	disseminated eosinophilic collagen disease	30.4	RNASE3 IL5
2	scabies	30.4	IL5 CCL11
3	cytokine deficiency	30.3	IL5 IL13
4	mikulicz disease	30.1	IL5 IL4 IL13
5	igg4-related disease	29.8	IL4 IL33
6	autoimmune disease	29.8	IL5 IL4 IL13 CCL5
7	ulcerative colitis	29.7	IL4 IL13 CCR3
8	colitis	29.7	IL4 IL13 CCR3
9	folliculitis	29.5	IL5 IL4 CCL5 CCL11
10	otitis media	29.4	RNASE3 IL5 IL4 IGHE CCL11
11	urticaria	29.3	RNASE3 IL5 IL4 IL13 IGHE
12	behcet syndrome	29.1	IL4 IL33 IL13
13	hypereosinophilic syndrome	28.7	RNASE3 IL5 IL4 IL13 IGHE IGES
14	lung disease	28.7	RNASE3 IL5 IL4 IL13 CCR3 CCL5
15	dermatitis	27.4	TSLP RNASE3 IL5 IL4 IL33 IL13
16	allergic rhinitis	27.3	RNASE3 IL5 IL4 IL13 IGHE IGES
17	rhinitis	26.9	TSLP RNASE3 IL5 IL4 IL33 IL13
18	allergic hypersensitivity disease	26.7	TSLP RNASE3 IL5 IL4 IL13 IGHE
19	asthma	25.8	TSLP RNASE3 IL5 IL4 IL33 IL13
20	dermatitis, atopic	25.3	TSLP RNASE3 IL5 IL4 IL33 IL13
21	nephrotic syndrome	10.6
22	loeffler endocarditis	10.4	RNASE3 IL5
23	nickel allergic contact dermatitis	10.4	IL5 IL4
24	papillary conjunctivitis	10.3	IL4 CCL11
25	wells syndrome	10.3	RNASE3 IL5
26	aztreonam allergy	10.3	IL5 IL13
27	ceftriaxone allergy	10.3	IL5 IL13
28	glomerulonephritis	10.3
29	angioimmunoblastic lymphadenopathy with dysproteinemia	10.3	IL5 IL13
30	corticosteroid allergy	10.3	IL5 IL4
31	cefaclor allergy	10.3	IL5 IL13
32	anisakiasis	10.3	RNASE3 IGHE
33	idiopathic nephrotic syndrome	10.3	IL4 IGHE
34	cefuroxime allergy	10.3	IL5 IL13
35	adhesive otitis media	10.3	RNASE3 CCL11
36	norwegian scabies	10.3	IL5 IL13
37	chronic meningitis	10.3	IL5 CCL11
38	ocular cicatricial pemphigoid	10.3	RNASE3 IL4
39	orange allergy	10.3	IL5 IL13
40	immunodeficiency with hyper-igm, type 1	10.3	IL4 IGHE
41	scleritis	10.3	IL5 IL4
42	opisthorchiasis	10.2	IL4 IGES
43	drug allergy	10.2	IL5 IGHE
44	vasculitis	10.2
45	lymphadenitis	10.2
46	maxillary sinusitis	10.2	RNASE3 CCL5
47	endomyocardial fibrosis	10.2	RNASE3 IL5 IL4
48	elephantiasis	10.2	RNASE3 IL5 IL4
49	cow milk allergy	10.2	RNASE3 IL5 IL4
50	toxocariasis	10.2	RNASE3 IL5 IGHE

Graphical network of the top 20 diseases related to Kimura Disease:

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Symptoms & Phenotypes for Kimura Disease

Human phenotypes related to Kimura Disease:

⁵⁸ ³¹ (show all 7)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	eosinophilia ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0001880
2	follicular hyperplasia ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002729
3	increased circulating total ige level ³¹	hallmark (90%)		HP:0003212
4	abnormal salivary gland morphology ³¹	occasional (7.5%)		HP:0010286
5	lymphadenopathy ⁵⁸		Frequent (79-30%)
6	increased ige level ⁵⁸		Very frequent (99-80%)
7	abnormality of the salivary glands ⁵⁸		Occasional (29-5%)

MGI Mouse Phenotypes related to Kimura Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.81	CCL11 CCL5 CCR3 CRLF2 IL13 IL33
2	digestive/alimentary	MP:0005381	9.73	CRLF2 IL13 IL33 IL4 IL5 TSLP
3	immune system	MP:0005387	9.61	CCL11 CCL5 CCR3 CRLF2 IL13 IL33
4	respiratory system	MP:0005388	9.23	CCL11 CCR3 CRLF2 IL13 IL33 IL4

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Drugs & Therapeutics for Kimura Disease

Search Clinical Trials , NIH Clinical Center for Kimura Disease

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Genetic Tests for Kimura Disease

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Anatomical Context for Kimura Disease

MalaCards organs/tissues related to Kimura Disease:

⁴⁰

Lymph Node, Skin, Salivary Gland, T Cells, Kidney, Bone, Lung

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Publications for Kimura Disease

Articles related to Kimura Disease:

(show top 50) (show all 201)

#	Title	Authors	PMID	Year
1	Kimura disease: review of the literature. ⁶¹ ⁵²	Sun QF...Jin DJ	18808562	2008
2	Comparison of the efficacy of different treatment modalities for Kimura's disease. ⁵²	Ye P...Peng X	27614905	2017
3	Thrombotic storm in Kimura disease. ⁵⁴ ⁶¹	Liu H...Lottenberg R	19468829	2010
4	Kimura's disease with eosinophilic panniculitis--treated with cyclosporine: a case report. ⁵⁴ ⁶¹	Maleki D...Gholami N	20236545	2010
5	Diagnostic dilemma of kimura disease of eyelids. ⁶¹	Ting SL...Than TA	32008028	2020
6	Human Polyomavirus 6 with the Asian/Japanese Genotype in Cases of Kimura Disease and Angiolymphoid Hyperplasia with Eosinophilia. ⁶¹	Hashida Y...Daibata M	31981580	2020
7	Kimura disease in a 2-year-old boy with generalized lymphadenopathy. ⁶¹	Fujiwara M...Araki T	31833620	2019
8	Tissue-infiltrating immune cells contribute to understanding the pathogenesis of Kimura disease: A case report. ⁶¹	Maehara T...Nakamura S	31852109	2019
9	The clinicopathological characteristics of Kimura disease in Chinese patients. ⁶¹	Zhang X...Jiao Y	31440918	2019
10	Kimura disease: a case report of a rare illness presenting as a common complaint. ⁶¹	Rush ML...Bhansali P	30808157	2019
11	Recurrent Kimura Disease: Original Observations in 2 Patients With an Unusual Protracted Course of the Inflammatory Process. ⁶¹	Theodorou DJ...Kakitsubata Y	31651639	2019
12	Mepolizumab as an effective treatment for Kimura's disease associated with ulcerative colitis: A case report. ⁶¹	Al Shammari F...Al Otaibi E	31681687	2019
13	Groin abnormalities: ultrasonographic and clinical findings. ⁶¹	Yang DM...Won KY	31786905	2019
14	Kimura disease with nephrotic syndrome in a child- A rare association. ⁶¹	Majumder A...Sen D	31361234	2019
15	Kimura disease: case report and brief review of literature. ⁶¹	Dhingra H...Alva SR	31086850	2019
16	Angiolymphoid hyperplasia with eosinophilia and Kimura disease overlap, with evidence of diffuse visceral involvement. ⁶¹	Marka A...LeBlanc RE	30362278	2019
17	An unexpected asymptomatic epiglottal site of Kimura disease. ⁶¹	Dezoteux F...Carpentier O	30712651	2019
18	Kimura disease and immunoglobulin G4-related disease: a possible overlap in a patient with severe systemic symptoms. ⁶¹	Biedron G...Musial J	30543201	2019
19	Concurrent Kidney Glomerular and Interstitial Lesions Associated with Kimura's Disease. ⁶¹	Yang S...Chen W	31387106	2019
20	A rare case of inguinal kimura disease. ⁶¹	Gregory X...Nur Aklina R	30350814	2018
21	Computerized tomography features and clinicopathological analysis of Kimura disease in head and neck. ⁶¹	Zhang L...Zhang CQ	30186444	2018
22	Orbital Mass With Features of Both Kimura Disease and Immunoglobulin G4-Related Disease. ⁶¹	Lee JH...Kim SC	29923967	2018
23	Imaging of Benign Neoplastic and Nonneoplastic Salivary Gland Tumors. ⁶¹	Ginat DT	29622111	2018
24	Kimura Disease: A differential diagnosis in a nephrotic child. ⁶¹	Aziz A...Zawawi N	30302182	2018
25	Kimura Disease: A Rare Case Report From Himalayan Region. ⁶¹	Malhotra M...Kumar S	29238694	2017
26	Kimura disease of buccal region in a pediatric patient with nephrotic syndrome: A case report. ⁶¹	Lee DH...Lim SC	29310412	2017
27	Successful therapy with mycophenolic acid in a membranous glomerulonephritis due to Kimura disease . ⁶¹	Gaillard J...Spertini F	28853699	2017
28	Kimura disease. ⁶¹	Zhou P...Zhang Y	29469792	2017
29	Basophils are increased and express increased levels of interleukin-4 in the parotid lesions of Kimura disease. ⁶¹	Nonaka M...Yoshihara T	29094020	2017
30	A Rare Case of Kimura Disease with Bilateral Parotid Involvement. ⁶¹	Woo SH...Kim MK	28946727	2017
31	Treatment of Kimura disease with mycophenolate mofetil monotherapy. ⁶¹	Shah K...Zang JB	28932783	2017
32	Expression of the interleukin-21 and phosphorylated extracellular signal regulated kinase 1/2 in Kimura disease. ⁶¹	Chen QL...Yin XP	28108473	2017
33	Superficial Parotidectomy Plane for Debulking Surgery in Kimura Disease. ⁶¹	Sharma R	28468187	2017
34	Recurrent Kimura Disease of the Inner Canthus With No Lymphadenopathy. ⁶¹	Francis IL...Telisinghe PU	26020715	2017
35	Acute Limb Ischemia and Coronary Artery Disease in a Case of Kimura's Disease. ⁶¹	Heo W...Nam KH	28382271	2017
36	[An indolent and fluctuating subcutaneous mass of the skull in a 5-year-old patient: Diagnostic approach and difficulties]. ⁶¹	Beck J...Pietrement C	28233718	2017
37	Nephrotic syndrome during the tapering of oral steroids after pathological diagnosis of Kimura disease from a lacrimal gland mass: case report and review of 10 Japanese patients. ⁶¹	Matsuo T...Kinomura M	29279552	2017
38	Detailed Imaging Findings in a Rare Case of Kimura Disease, with Special Mention on Diffusion Weighted Imaging. ⁶¹	Syed M...Sharma A	29657623	2017
39	Kimura disease in a Maori man with nephrotic syndrome. ⁶¹	Alnasrallah B...Yehia M	27981775	2016
40	Concurrent Kimura disease and lupus nephritis: A case report. ⁶¹	Wang H...Mao Y	27741124	2016
41	Eosinophilia and multiple lymphadenopathy: Kimura disease, a rare, but benign condition. ⁶¹	Garcia Carretero R...Vazquez-Gomez O	27581232	2016
42	Kimura Disease of the Breast - A Previously Undescribed Entity. ⁶¹	Kakkar A...Shukla NK	27058987	2016
43	Human Polyomavirus-6 Infecting Lymph Nodes of a Patient With an Angiolymphoid Hyperplasia With Eosinophilia or Kimura Disease. ⁶¹	Rascovan N...Desnues C	26962076	2016
44	Kimura Disease Presenting as Forehead Soft Mass. ⁶¹	Choi HJ	27100647	2016
45	A case of refractory Kimura disease with a buccal bulky mass successfully treated with low-dose cyclosporine A: report and review of the literature. ⁶¹	Miki H...Sumida T	26666475	2016
46	Uncommon clinical presentation of Kimuras disease as bilateral retroauricular masses in a young Malian male: successful surgical approach. ⁶¹	Fama F...Guarneri C	27373132	2016
47	Synchronous Kimura lesions at two different sites-a diagnostic dilemma! ⁶¹	Rodrigues G...Ravi B	27190775	2016
48	Kimura disease: No age or ethnicity limit. ⁶¹	AlGhamdi FE...AlGarni MA	26905356	2016
49	Epithelioid Hemangioma (Angiolymphoid Hyperplasia With Eosinophilia) of the Heart With Peripheral Eosinophilia and Nephrotic Syndrome. ⁶¹	Machado I...Llombart-Bosch A	26338719	2016
50	An Unusual Clinical Presentation of Kimura Disease Manifesting with a Typical Cephalocervical Lesion and an Atypical Subcutaneous Hip Mass Lesion. ⁶¹	Baba A...Aoyagi Y	27086824	2016

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Genes for Kimura Disease

Genes related to Kimura Disease (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	IL5	Interleukin 5	Protein Coding	20.74	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	17259809 9779259 2265119 (more) 8092143 9470918 12653173
2	RNASE3	Ribonuclease A Family Member 3	Protein Coding	20.35	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	17259809 8050202
3	IGES	Immunoglobulin E Concentration, Serum	Genetic Locus	17.55	Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19468829 19620037
4	IGHE	Immunoglobulin Heavy Constant Epsilon	Protein Coding	15.31	Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	1918403 15542945 20236545
5	IL4	Interleukin 4	Protein Coding	12.61	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	11.85	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	IL13	Interleukin 13	Protein Coding	11.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	11.25	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	TSLP	Thymic Stromal Lymphopoietin	Protein Coding	11.25	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	CCR3	C-C Motif Chemokine Receptor 3	Protein Coding	11.24	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	IL33	Interleukin 33	Protein Coding	11.02	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	CRLF2	Cytokine Receptor Like Factor 2	Protein Coding	10.87	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Kimura Disease

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Expression for Kimura Disease

Search GEO for disease gene expression data for Kimura Disease.

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Pathways for Kimura Disease

Pathways related to Kimura Disease according to GeneCards Suite gene sharing:

(show all 26)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.81	RNASE3 IL5 IL4 IL33 IL13 IGHE
2	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.43	TSLP IL5 IL4 IL33 IL13 CRLF2
3	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.22	IL5 IL4 IL13 CCR3 CCL5 CCL11
4	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.16	IL5 IL4 IL33 IL13 IGHE CCL5
5	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.12	IL5 IL4 IL13 CCR3 CCL5 CCL11
6	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.69	RNASE3 IL5 IL4 IL13 CCL11
7	Immune response Fc epsilon RI pathway ²² Show member pathways Fc epsilon RI signaling pathway ³⁶ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²² VEGF signaling pathway ³⁶	12.42	IL5 IL4 IL13 IGHE
8	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.19	IL5 IL4 IL13 CCL11
9	Immune response CCR3 signaling in eosinophils ²² Show member pathways Inhibitory action of Lipoxins on neutrophil migration ²²	12.15	CCR3 CCL5 CCL11
10	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.13	CCR3 CCL5 CCL11
11	JAK-STAT signaling pathway (KEGG) ³⁶ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴	12.09	TSLP IL5 IL4 IL13 CRLF2
12	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.85	IL5 IL4 CCR3
13	Interleukin-4 and 13 signaling ⁶⁵	11.81	IL4 IL13 IGHE CCL11
14	Glucocorticoid receptor regulatory network ¹	11.67	IL5 IL4 IL13
15	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁴	11.56	IL4 IL13 CCL5 CCL11
16	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.54	TSLP IL5 IL4 IL33 IL13 CRLF2
17	IL4-mediated signaling events ¹	11.47	IL5 IL4 IGHE CCL11
18	Interleukin-10 signaling ⁶⁵	11.4	IL4 IL13 CCL5
19	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway ¹	11.37	TSLP CRLF2 CCL11
20	Lung fibrosis ¹	11.23	IL5 IL4 IL13 CCR3 CCL5 CCL11
21	Development and heterogeneity of the ILC family ¹	11.16	TSLP IL5 IL4 IL33 IL13
22	Inflammatory Response Pathway ¹	11.14	IL5 IL4
23	Cytokines and Inflammatory Response ¹	11.13	IL5 IL4 IL13
24	OX40 Pathway ⁶³	11.07	IL5 IL4 IL13
25	G-protein signaling_Rap2B regulation pathway ²²	10.87	IL5 IL4 IL13 CCL5 CCL11
26	Th2 Differentiation Pathway ⁶⁴	10.76	IL5 IL4 IL33 IL13 CRLF2 CCL11

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GO Terms for Kimura Disease

Cellular components related to Kimura Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.56	TSLP RNASE3 IL5 IL4 IL33 IL13
2	external side of plasma membrane	GO:0009897	9.46	IL13 IGHE CRLF2 CCR3
3	extracellular region	GO:0005576	9.32	TSLP RNASE3 IL5 IL4 IL33 IL13

Biological processes related to Kimura Disease according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	chemotaxis	GO:0006935	9.73	CCR3 CCL5 CCL11
2	inflammatory response	GO:0006954	9.72	IL5 IL13 CCR3 CCL5 CCL11
3	chemokine-mediated signaling pathway	GO:0070098	9.67	CCR3 CCL5 CCL11
4	negative regulation of endothelial cell apoptotic process	GO:2000352	9.59	IL4 IL13
5	lymphocyte chemotaxis	GO:0048247	9.58	CCL5 CCL11
6	positive regulation of JAK-STAT cascade	GO:0046427	9.58	IL5 CCL5
7	interleukin-7-mediated signaling pathway	GO:0038111	9.57	TSLP CRLF2
8	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.56	TSLP IL4 IL13 CCL5
9	eosinophil chemotaxis	GO:0048245	9.55	CCL5 CCL11
10	positive regulation of macrophage activation	GO:0043032	9.54	IL33 IL13
11	positive regulation of B cell proliferation	GO:0030890	9.54	IL5 IL4 IL13
12	positive regulation of immunoglobulin secretion	GO:0051024	9.52	IL5 IL33
13	positive regulation of interleukin-5 production	GO:0032754	9.51	TSLP IL33
14	immune response	GO:0006955	9.5	IL5 IL4 IL13 IGHE CCR3 CCL5
15	positive regulation of interleukin-5 secretion	GO:2000664	9.48	TSLP CRLF2
16	positive regulation of STAT cascade	GO:1904894	9.46	TSLP CRLF2
17	positive regulation of mast cell activation	GO:0033005	9.43	TSLP CRLF2
18	negative regulation of complement-dependent cytotoxicity	GO:1903660	9.4	IL4 IL13
19	positive regulation of interleukin-13 production	GO:0032736	9.33	TSLP IL4 IL33
20	cytokine-mediated signaling pathway	GO:0019221	9.17	IL5 IL4 IL13 IGHE CRLF2 CCL5

Molecular functions related to Kimura Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.17	TSLP IL5 IL4 IL33 IL13 CCL5
2	CCR chemokine receptor binding	GO:0048020	9.16	CCL5 CCL11
3	cytokine receptor binding	GO:0005126	8.96	IL4 IL13

Sources

Sources for Kimura Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia