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MCID: KLT001
MIFTS: 52

Klatskin's Tumor

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Klatskin's Tumor

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MalaCards integrated aliases for Klatskin's Tumor:

Name: Klatskin's Tumor 12 53 15
Klatskin Tumor 12 53 59 44 73
Hilar Cholangiocarcinoma 12 59 6
Perihilar Cholangiocarcinoma 53 73
Perihilar Extrahepatic Bile Duct Carcinoma 12
Hilar Cholangiocellular Carcinoma 12
Hilar Cca 59

Characteristics:

Orphanet epidemiological data:

59
klatskin tumor
Inheritance: Not applicable; Age of onset: Adult; Age of death: adult;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Liver diseases Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:4927
MeSH 44 D018285
NCIt 50 C36077
SNOMED-CT 68 6492006
Orphanet 59 ORPHA99978
ICD10 via Orphanet 34 C24.0
MESH via Orphanet 45 D018285
UMLS via Orphanet 74 C0206702
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Summaries for Klatskin's Tumor

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NIH Rare Diseases : 53 Klatskin tumors are are a type of cholangiocarcinoma that begins in an area called the hilum, where the left and right bile ducts join and leave the liver. It is the most common type of cholangiocarcinoma, accounting for more than half of all cases. Symptoms usually don't present until advanced stages of disease, when jaundice is the most common feature. Other symptoms include abdominal pain, unintentional weight loss, and a general feeling of being unwell (malaise).  The cause of Klatskin tumors is unknown. Studies suggest that a combination of genetic, environmental, and lifestyle factors (multifactorial) likely influence whether a person will develop cholangiocarcinoma. Because Klatskin tumors are often discovered after they have spread, they can be challenging to treat. Surgical removal of the tumor and relief of bile duct blockage are the main goals of treatment.

MalaCards based summary : Klatskin's Tumor, also known as klatskin tumor, is related to cholangiocarcinoma and hepatic tuberculosis, and has symptoms including abdominal pain, icterus and malaise. An important gene associated with Klatskin's Tumor is MIR373 (MicroRNA 373), and among its related pathways/superpathways are MicroRNAs in cancer and Proteoglycans in cancer. The drugs Bilirubin and Bismuth have been mentioned in the context of this disorder. Affiliated tissues include liver, b cells and lung, and related phenotypes are hepatomegaly and fever

Disease Ontology : 12 An intrahepatic cholangiocarcinoma arising near or at the confluence of the right and left hepatic ducts.

Wikipedia : 76 A Klatskin tumor (or hilar cholangiocarcinoma) is a cholangiocarcinoma (cancer of the biliary tree)... more...

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Related Diseases for Klatskin's Tumor

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Diseases related to Klatskin's Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 cholangiocarcinoma 31.7 MALAT1 MIR373 MMP9
2 hepatic tuberculosis 29.8 ALB SMUG1
3 intrahepatic cholangiocarcinoma 10.9
4 cholangitis 10.5
5 sclerosing cholangitis 10.4
6 cholangitis, primary sclerosing 10.2
7 extracranial arteriovenous malformation 10.2 MMP2 MMP9
8 focal myositis 10.2 MMP2 MMP9
9 villous adenocarcinoma 10.2 MMP2 MMP9
10 spastic entropion 10.2 MMP2 MMP9
11 lymphoma 10.2
12 lentigo maligna melanoma 10.2 MMP2 MMP9
13 psammomatous meningioma 10.2 MMP2 MMP9
14 acute transverse myelitis 10.2 MMP2 MMP9
15 transverse myelitis 10.2 MMP2 MMP9
16 senile ectropion 10.2 MMP2 MMP9
17 internal hemorrhoid 10.2 MMP2 MMP9
18 hepatocellular carcinoma 10.2
19 ischemic colitis 10.2 MMP2 MMP9
20 conjunctival nevus 10.2 MMP2 MMP9
21 corneal ulcer 10.2 MMP2 MMP9
22 multicentric osteolysis, nodulosis, and arthropathy 10.2 MMP14 MMP2
23 nasal cavity squamous cell carcinoma 10.2 MMP2 MMP9
24 winchester syndrome 10.2 MMP14 MMP2
25 odontogenic myxoma 10.2 MMP2 MMP9
26 obstructive jaundice 10.2
27 adenocarcinoma 10.2
28 laryngeal disease 10.2 MMP2 MMP9
29 hypertensive heart disease 10.2 MMP2 MMP9
30 aortic aneurysm, familial thoracic 1 10.1 MMP2 MMP9
31 pneumothorax 10.1 MMP2 MMP9
32 actinic keratosis 10.1 MMP14 MMP2
33 adenomyosis 10.1 MMP2 MMP9
34 infantile liver failure syndrome 1 10.1
35 gallbladder cancer 10.1
36 degos 'en cocarde' erythrokeratoderma 10.1
37 light chain deposition disease 10.1 MMP14 MMP2 MMP9
38 aortic aneurysm, familial abdominal, 1 10.1 MMP14 MMP2 MMP9
39 preterm premature rupture of the membranes 10.1 MMP9 PGRMC1
40 microvascular complications of diabetes 3 10.1 ALB MALAT1
41 b-cell lymphomas 10.1
42 neuroendocrine tumor 10.1
43 keratoconus 10.1 MMP14 MMP2 MMP9
44 tongue cancer 10.1 MALAT1 MMP2 MMP9
45 aging 10.1
46 liver cirrhosis 10.1
47 cholestasis 10.1
48 in situ carcinoma 10.1
49 left-sided gallbladder 10.1
50 hypoxia 10.1

Graphical network of the top 20 diseases related to Klatskin's Tumor:



Diseases related to Klatskin's Tumor
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Symptoms & Phenotypes for Klatskin's Tumor

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Human phenotypes related to Klatskin's Tumor:

59 32 (show all 10)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hepatomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0002240
2 fever 59 32 occasional (7.5%) Occasional (29-5%) HP:0001945
3 fatigue 59 32 occasional (7.5%) Occasional (29-5%) HP:0012378
4 abdominal pain 59 32 occasional (7.5%) Occasional (29-5%) HP:0002027
5 weight loss 59 32 occasional (7.5%) Occasional (29-5%) HP:0001824
6 venous thrombosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0004936
7 jaundice 59 32 hallmark (90%) Very frequent (99-80%) HP:0000952
8 extrahepatic cholestasis 59 32 hallmark (90%) Very frequent (99-80%) HP:0012334
9 lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0002716
10 cholangiocarcinoma 59 32 hallmark (90%) Very frequent (99-80%) HP:0030153

UMLS symptoms related to Klatskin's Tumor:


abdominal pain, icterus, malaise
Sources

Drugs & Therapeutics for Klatskin's Tumor

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Drugs for Klatskin's Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bilirubin Phase 4 635-65-4 5280352
2
Bismuth Phase 4 7440-69-9 16682734 105143
3
Gemcitabine Approved Phase 3,Phase 2,Phase 1 95058-81-4 60750
4
Trioxsalen Approved Phase 3,Not Applicable 3902-71-4 5585
5
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
6 Liver Extracts Phase 2, Phase 3,Phase 1,Not Applicable
7 Dermatologic Agents Phase 3,Phase 2,Not Applicable
8 Photosensitizing Agents Phase 3,Phase 2,Not Applicable
9 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1,Not Applicable
10 Antimetabolites Phase 3,Phase 2,Phase 1,Not Applicable
11
s 1 (combination) Phase 3
12 Hematoporphyrin Derivative Phase 3,Not Applicable
13 Dihematoporphyrin Ether Phase 3,Not Applicable
14 Ether Phase 3,Not Applicable
15 Antiviral Agents Phase 3,Phase 2,Phase 1
16 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
17 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
18 Immunologic Factors Phase 3,Phase 2,Phase 1
19 Hematoporphyrins Phase 3,Not Applicable
20
Capecitabine Approved, Investigational Phase 2,Phase 1,Not Applicable 154361-50-9 60953
21
Fluorouracil Approved Phase 2,Not Applicable 51-21-8 3385
22
Trametinib Approved Phase 2 871700-17-3 11707110
23
leucovorin Approved Phase 2 58-05-9 6006 143
24
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
25
Nicotinamide Approved, Investigational Phase 2 98-92-0 936
26
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
27
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
28
Temoporfin Approved, Investigational Phase 2 122341-38-2
29
Ceritinib Approved Phase 2 1032900-25-6
30
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
31
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
32
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
33 Hematinics Phase 1, Phase 2,Phase 2,Not Applicable
34 Bone Density Conservation Agents Phase 2
35 Vitamins Phase 2
36 Trace Elements Phase 2
37 Calcium, Dietary Phase 2
38 Vitamin B9 Phase 2
39 Micronutrients Phase 2
40 Protein Kinase Inhibitors Phase 2
41 Antidotes Phase 2
42 Vitamin B Complex Phase 2
43 Protective Agents Phase 2
44 Folate Phase 2
45 Nicotinic Acids Phase 2
46 Vitamin B3 Phase 2
47
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
48 Angiogenesis Inhibitors Phase 1, Phase 2
49 Angiogenesis Modulating Agents Phase 1, Phase 2
50 Anti-Inflammatory Agents Phase 2

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Quality of Life in Patients With Unresectable Hilar Cholangiocarcinoma on Palliative Metallic Stent Versus Plastic Stent Unknown status NCT00746538 Phase 4
2 Preoperative Biliary Drainage for Resectable Hilar Cholangiocarcinoma Unknown status NCT00797121 Phase 4
3 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
4 Efficacy and Cost Analysis of Plastic Stent Compare to Metallic Stent in Hilar Cholangiocarcinoma Completed NCT00721175 Phase 4
5 Percutaneous Bilateral Versus Unilateral Metal Stent for Hilar Cholangiocarcinoma Unknown status NCT02108145 Phase 2, Phase 3
6 S-1 and Photodynamic Therapy in Cholangiocarcinoma Completed NCT00869635 Phase 3 S-1 Chemotherapy
7 Efficacy and Safety Study of PDT Using Photofrin in Unresectable Advanced Perihilar Cholangiocarcinoma (OPUS) Terminated NCT02082522 Phase 3 Photodynamic therapy-Photofrin;Chemotherapy regimen
8 Safety Study of Liver Transplantation for Hilar Cholangiocarcinoma Unknown status NCT02178280 Phase 1, Phase 2
9 Photodynamic Therapy in Locally Advanced Hilar Cholangiocarcinoma Unknown status NCT02725073 Phase 2
10 Regorafenib Versus Placebo to Treat Cholangiocarcinoma Unknown status NCT02162914 Phase 2 Regorafenib/active;Regorafenib/placebo
11 Trametinib or Combination Chemotherapy in Treating Patients With Refractory or Advanced Biliary or Gallbladder Cancer or That Cannot Be Removed by Surgery Completed NCT02042443 Phase 2 Capecitabine;Fluorouracil;Leucovorin Calcium;Trametinib
12 Sorafenib Tosylate and Erlotinib Hydrochloride in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT01093222 Phase 2 Erlotinib Hydrochloride;Sorafenib Tosylate
13 Efficacy and Safety Study of PDT Using Deuteporfin for Unresectable Advanced Perihilar Cholangiocarcinoma Recruiting NCT02955771 Phase 2
14 Fluorescence Image Guided Surgery in Cholangiocarcinoma Recruiting NCT03620292 Phase 1, Phase 2 Bevacizumab-IRDye800CW
15 Safety and Tumoricidal Effect of Low Dose Foscan PDT in Patients With Inoperable Bile Duct Cancers Recruiting NCT03003065 Phase 2 Temoporfin
16 A Study of ABC294640 (Yeliva ®) in the Treatment of Patients With Advanced Cholangiocarcinoma Recruiting NCT03377179 Phase 2 ABC294640
17 A Phase II Trial of LDK378 in ROS1 and /or ALK Over-expressed Advanced Intrahepatic or Hilar Cholangiocarcinoma Terminated NCT02374489 Phase 2 LDK378
18 Phase II SBRT & Chemo for Unresectable Cholangiocarcinoma Followed by Liver Transplantation Terminated NCT01151761 Phase 2 Gemcitabine;Cisplatin;Carboplatin;Capecitabine;5FU
19 ADH-1, Gemcitabine Hydrochloride and Cisplatin in Treating Patients With Locally Advanced or Metastatic Pancreatic or Biliary Tract Cancer That Cannot Be Removed by Surgery Completed NCT01825603 Phase 1 ADH-1;Cisplatin;Gemcitabine Hydrochloride
20 Cyberknife Radiosurgery Boost for Hilar Cholangiocarcinoma (Klatskin Tumor) Terminated NCT00630890 Phase 1
21 Ricolinostat, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients With Unresectable or Metastatic Cholangiocarcinoma Withdrawn NCT02856568 Phase 1 Cisplatin;Gemcitabine Hydrochloride;Ricolinostat
22 Liver Transplantation for Hilar Cholangiocarcinoma in Association With Neoadjuvant Radio- and Chemo-therapy Unknown status NCT01549795 Not Applicable Capecitabine
23 Best Biliary Drainage Option in Advanced Klatskin Tumor Completed NCT03104582 Not Applicable
24 Surgical Treatment of Hilar Cholangiocarcinoma: Minor or Major Liver Resection? Completed NCT00733200 Not Applicable
25 Single Versus Multiple Deployment of Metallic Stents for Inoperable Malignant Hilar Biliary Obstruction Completed NCT02166970 Not Applicable
26 The Role of Gadoxetate (Eovist) Enhanced CT in Evaluating Cholangiocarcinoma Completed NCT01673802 Early Phase 1 CT scan
27 Photodynamic Therapy With Polyhematoporphyrin for Malignant Biliary Obstruction Completed NCT02504957 Not Applicable
28 RALPPS in Patients With Hilar and Intrahepatic Cholangiocarcinoma Completed NCT03320980
29 Safety and Efficacy of Photodynamic Therapy for Bile Duct Invasion of Hepatocellular Carcinoma Completed NCT01506115 Not Applicable Photofrin
30 Stereotactic Body Radiation Therapy for Unresectable Perihilar Cholangiocarcinoma Recruiting NCT03307538 Not Applicable
31 Impact of Three-dimensional Visualization on Operation Strategy and Complications for Hilar Cholangiocarcinoma Recruiting NCT03132649
32 Effect of 37℃ Non-ionic Contrast Agent During ERCP Procedure in Hilar Cholangiocarcinoma Recruiting NCT03104569 Not Applicable
33 Liver Resection Versus Radio-chemotherapy-Transplantation for Hilar Cholangiocarcinoma Recruiting NCT02232932 Not Applicable
34 Application of Endoscopic Scissors Cutting ENBD Tube in the Treatment of Malignant Hilar Biliary Strictures Recruiting NCT03353181 Not Applicable
35 A Trial of Percutaneous vs. Endoscopic Drainage of Suspected Klatskin Tumors Recruiting NCT03172832 Not Applicable
36 Metal Stents (Moving Cell Stent) for Inoperable Tumors of the Bile Duct Tract Recruiting NCT03788655
37 Superior Bilioenteric Anastomosis by Magnetic Compressive Technique Recruiting NCT02801500 Not Applicable
38 Effectiveness of Prophylactic Antibiotics to Prevent Post Endoscopic Retrograde Cholangio Pancreatography Bacteremia in Biliary Obstruction Patient Recruiting NCT02958059 Not Applicable
39 Comparing Three Dimension Laparoscopic Versus Open Surgery for Perihiliar Cholangiocarcinoma Recruiting NCT03383796 Not Applicable
40 Efficacy and Tolerability of Hemopatch After Hepatic Resection Recruiting NCT03323359 Not Applicable
41 Expanded Access for the Treatment of Advanced Cholangiocarcinoma With ABC294640 (Yeliva ®) Available NCT03414489 ABC294640
42 Tampa Associating Microwave Liver Ablation With Portal Vein Ligation for Staged Hepatectomy (TAMLAPS) Enrolling by invitation NCT03739164
43 Optimization of Health Expenditure in Liver Surgery Enrolling by invitation NCT01715402
44 Process Optimization of Preoperative Biliary Drainage in Patients With Malignant Obstructive Jaundice Not yet recruiting NCT03527875 Not Applicable
45 Liver Transplantation for Cholangiocarcinoma Terminated NCT00708877 Not Applicable
46 Coregistration of 18F-FDG-PET and MRI in the Staging of Potentially Resectable Hilar Cholangiocarcinoma: a Pilot Study Withdrawn NCT00604266

Search NIH Clinical Center for Klatskin's Tumor

Cochrane evidence based reviews: klatskin tumor

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Genetic Tests for Klatskin's Tumor

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Anatomical Context for Klatskin's Tumor

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MalaCards organs/tissues related to Klatskin's Tumor:

41
Liver, B Cells, Lung, Brain, Bone, Heart, Tongue
Sources

Publications for Klatskin's Tumor

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Articles related to Klatskin's Tumor:

(show top 50) (show all 93)
# Title Authors Year
1
Primary large cell neuroendocrine carcinoma of the common hepatic duct mimicking a Klatskin tumor. ( 29466852 )
2018
2
Liver Transplant for Perihilar Cholangiocarcinoma (Klatskin Tumor): The Essential Role of Patient Selection. ( 29911960 )
2018
3
Preoperative Portal Vein Embolization Alone with Biliary Drainage Compared to a Combination of Simultaneous Portal Vein, Right Hepatic Vein Embolization and Biliary Drainage in Klatskin Tumor. ( 30238334 )
2018
4
Heterotopic chondroid tissue of the main bile duct mimicking Klatskin tumor: case report and review of the literature. ( 30499056 )
2018
5
Primary extrahepatic bile duct neuroendocrine tumor with obstructive jaundice masquerading as a Klatskin tumor. ( 28596824 )
2017
6
Single synchronous liver metastasis from Merkel cell carcinoma mimicking a klatskin tumor: A diagnostic challenge. ( 28473299 )
2017
7
Hepatoduodenal lymph node metastasis mimicking Klatskin tumor in a patient with sigmoid colon mucinous cancer. ( 28828110 )
2017
8
Klatskin Tumor. ( 28985102 )
2017
9
Best option for preoperative biliary drainage in Klatskin tumor: A systematic review and meta-analysis. ( 29069029 )
2017
10
The Klatskin Tumor That Wasn't: An Unusual Presentation of Sarcoidosis. ( 27761479 )
2016
11
Percutaneous Irreversible Electroporation of Unresectable Hilar Cholangiocarcinoma (Klatskin Tumor): A Case Report. ( 25994516 )
2016
12
Neuroendocrine Carcinoma of the Gallbladder Masquerading as a Klatskin Tumor in a 74-Year-Old Male. ( 26036328 )
2016
13
Palliative Locoregional Treatment for Unresectable Nonmetastatic Klatskin Tumor: Percutaneous Transhepatic Biliary Drainage Combined With 3-dimensional Conformal Radiotherapy. ( 27035079 )
2016
14
Stent placement above the sphincter of Oddi permits implementation of neoadjuvant chemotherapy in patients with initially unresectable Klatskin tumor. ( 27092322 )
2016
15
Y-configured metallic stent combined with (125)I seed strands cavity brachytherapy for a patient with type IV Klatskin tumor. ( 27648091 )
2016
16
Bilateral ovarian metastasis of a Klatskin tumor: A rare case. ( 28913125 )
2016
17
Primary extrahepatic bile duct lymphoma mimicking Klatskin's tumor, dramatic response to chemotherapy. ( 25681815 )
2015
18
Metachronous Ampulla of Vater Carcinoma after Curative-Intent Surgery for Klatskin Tumor. ( 26305204 )
2015
19
Metastasis-associated in colon cancer 1 is an independent prognostic biomarker for survival in Klatskin tumor patients. ( 25953673 )
2015
20
Hilar traumatic neuroma masquerading as Klatskin tumor. ( 26591958 )
2015
21
Placement of ¹²⁵I seed strands and stents for a type IV Klatskin tumor. ( 25574114 )
2015
22
Comparative Analysis of Left- Versus Right-sided Resection in Klatskin Tumor Surgery: can Lesion Side be Considered a Prognostic Factor? ( 25952531 )
2015
23
Klatskin tumor: Diagnosis, preoperative evaluation and surgical considerations. ( 26298684 )
2015
24
Two Cases of Type Va Extrahepatic Bile Duct Duplication With Distal Klatskin Tumor Surgically Treated with Whipple Procedure and Hepaticojejunostomy. ( 26504879 )
2015
25
An unresectable Klatskin's tumor? ( 24780210 )
2014
26
[Perihilar cholangiocarcinoma (Klatskin tumor)]. ( 24464335 )
2014
27
Common hepatic duct stricture: are lithiasis and negative brush cytology enough to rule out Klatskin tumor? ( 25083310 )
2014
28
Early detection of Klatskin tumor through the hepaticoduodenostomy. ( 25682637 )
2014
29
Evolution of surgery for Klatskin tumor demonstrates improved outcome: a single center analysis. ( 25688507 )
2014
30
Surgical strategies in patients with advanced hilar cholangiocarcinoma (Klatskin tumor). ( 23242846 )
2013
31
Extrahepatic biliary cystadenocarcinoma mimicking Klatskin tumor. ( 23702875 )
2013
32
Spindle-cell variant of primary cutaneous follicle center lymphoma spreading to the hepatobiliary tree, mimicking Klatskin tumor. ( 23167279 )
2013
33
Novel prognostic scoring system after surgery for Klatskin tumor. ( 23317618 )
2013
34
Does preoperative portal vein embolization have any impact on the outcome of right-side hepatectomy for Klatskin tumor? ( 23835729 )
2013
35
The curious case of a Klatskin tumor. ( 24369037 )
2013
36
Transhepatic transanastomotic stent, A reliable method for hepatojejunostomy and prevention of anastomotic leakage following radical resection in patients suffering from klatskin tumor. ( 24516837 )
2013
37
Origin and pathological characteristics of Klatskin tumor: a case report and literature review. ( 22535609 )
2012
38
Autoimmune cholangitis mimicking a klatskin tumor: a case report. ( 21955859 )
2011
39
Biliary Actinomycosis Mimicking a Klatskin Tumor. ( 21766219 )
2011
40
Chemotherapy versus surgery in primary B-cell lymphoma masquerading as Klatskin tumor-a diagnostic and therapeutic dilemma. ( 20335788 )
2011
41
Multidisciplinary management of hilar cholangiocarcinoma (Klatskin tumor): extended resection is associated with improved survival. ( 21115233 )
2011
42
Extent of liver resection for hilar cholangiocarcinoma (Klatskin tumor): how much is enough? ( 21540600 )
2011
43
A primary biliary diffuse large B-cell lymphoma mimicking Klatskin Tumor in an HIV patient. ( 21985856 )
2011
44
Portal vein encasement complicates resection of Klatskin's tumor. ( 20135922 )
2010
45
[A case of undifferentiated (embryonal) liver sarcoma mimicking klatskin tumor in an adult]. ( 20168062 )
2010
46
Primary neuroendocrine tumor of the extrahepatic biliary tree mimicking Klatskin tumor. ( 20922208 )
2010
47
Surgical treatment of Klatskin tumor: liver resection versus transplantation. ( 21443081 )
2010
48
[Hilar cholangiocarcinoma (Klatskin's tumor): up-to-date radiologic diagnosis, intervention and treatment possibilities]. ( 19401964 )
2009
49
The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis. ( 19330734 )
2009
50
Klatskin tumor--palliative therapy: the jury is still out or may be not yet in... . ( 19111687 )
2009
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Variations for Klatskin's Tumor

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ClinVar genetic disease variations for Klatskin's Tumor:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 APC NM_000038.5(APC): c.4658C> T (p.Ala1553Val) single nucleotide variant Uncertain significance GRCh37 Chromosome 5, 112175949: 112175949
2 APC NM_000038.5(APC): c.4658C> T (p.Ala1553Val) single nucleotide variant Uncertain significance GRCh38 Chromosome 5, 112840252: 112840252
Sources

Expression for Klatskin's Tumor

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Search GEO for disease gene expression data for Klatskin's Tumor.
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Pathways for Klatskin's Tumor

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Pathways related to Klatskin's Tumor according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
MicroRNAs in cancer 37
12.18 MIR373 MMP9 WNT3
2
Proteoglycans in cancer 37
11.91 MMP2 MMP9 WNT3
3
Adhesion 4
11.59 MMP14 MMP2 MMP9
4
Matrix Metalloproteinases 1
Show member pathways
 11.43 MMP14 MMP2 MMP9
5
amb2 Integrin signaling 1
11.19 MMP2 MMP9
6
Osteopontin-mediated events 1
Show member pathways
 11.15 MMP2 MMP9
7
AGE/RAGE pathway 1
11.15 MMP14 MMP2 MMP9
8
Colorectal Cancer Metastasis 64
11.14 MMP14 MMP2 MMP9 WNT3
9
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.01 MMP2 MMP9
10
A-beta Pathways: Uptake and Degradation 65
10.96 MMP2 MMP9
11
Cell adhesion_ECM remodeling 22
10.92 MMP14 MMP2 MMP9
12
Plasma membrane estrogen receptor signaling 1
10.82 MMP2 MMP9
13
A-beta Pathways: Plaque Formation and APP Metabolism 65
10.73 MMP2 MMP9
Sources

GO Terms for Klatskin's Tumor

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Cellular components related to Klatskin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 8.92 MMP14 MMP2 MMP9 WNT3

Biological processes related to Klatskin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.33 MMP14 MMP2 MMP9
2 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.32 MMP2 MMP9
3 embryo implantation GO:0007566 9.26 MMP2 MMP9
4 collagen catabolic process GO:0030574 9.13 MMP14 MMP2 MMP9
5 endodermal cell differentiation GO:0035987 8.8 MMP14 MMP2 MMP9

Molecular functions related to Klatskin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.33 MMP14 MMP2 MMP9
2 metallopeptidase activity GO:0008237 9.13 MMP14 MMP2 MMP9
3 metalloendopeptidase activity GO:0004222 8.8 MMP14 MMP2 MMP9
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Sources for Klatskin's Tumor

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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