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MCID: KLT001
MIFTS: 45

Klatskin's Tumor

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Klatskin's Tumor

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MalaCards integrated aliases for Klatskin's Tumor:

Name: Klatskin's Tumor 12 20 15 17
Klatskin Tumor 12 20 58 6 44 70
Hilar Cholangiocarcinoma 12 58 17
Perihilar Cholangiocarcinoma 20 70
Perihilar Extrahepatic Bile Duct Carcinoma 12
Hilar Cholangiocellular Carcinoma 12
Klatskin's Tumour 12
Klatskin Tumour 12
Hilar Cca 58

Characteristics:

Orphanet epidemiological data:

58
klatskin tumor
Inheritance: Not applicable; Age of onset: Adult; Age of death: adult;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Liver diseases Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:4927
MeSH 44 D018285
NCIt 50 C36077
SNOMED-CT 67 253017000
MESH via Orphanet 45 D018285
ICD10 via Orphanet 33 C24.0
UMLS via Orphanet 71 C0206702
Orphanet 58 ORPHA99978
UMLS 70 C0206702 C4045991
Sources

Summaries for Klatskin's Tumor

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GARD : 20 Klatskin tumors are are a type of cholangiocarcinoma that begins in an area called the hilum, where the left and right bile ducts join and leave the liver. It is the most common type of cholangiocarcinoma, accounting for more than half of all cases. Symptoms usually don't present until advanced stages of disease, when jaundice is the most common feature. Other symptoms include abdominal pain, unintentional weight loss, and a general feeling of being unwell ( malaise ). The cause of Klatskin tumors is unknown. Studies suggest that a combination of genetic, environmental, and lifestyle factors ( multifactorial ) likely influence whether a person will develop cholangiocarcinoma. Because Klatskin tumors are often discovered after they have spread, they can be challenging to treat. Surgical removal of the tumor and relief of bile duct blockage are the main goals of treatment.

MalaCards based summary : Klatskin's Tumor, also known as klatskin tumor, is related to sclerosing cholangitis and bilirubin metabolic disorder, and has symptoms including abdominal pain, icterus and malaise. An important gene associated with Klatskin's Tumor is MIR373 (MicroRNA 373), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Capecitabine and Bilirubin have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and ovary, and related phenotypes are jaundice and extrahepatic cholestasis

Disease Ontology : 12 An intrahepatic cholangiocarcinoma arising near or at the confluence of the right and left hepatic ducts.

Wikipedia : 73 A Klatskin tumor (or hilar cholangiocarcinoma) is a cholangiocarcinoma (cancer of the biliary tree)... more...

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Related Diseases for Klatskin's Tumor

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Diseases related to Klatskin's Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 466)
# Related Disease Score Top Affiliating Genes
1 sclerosing cholangitis 31.3 GPT F2 ALB
2 bilirubin metabolic disorder 30.7 GPT F2 ALB AFP
3 biliary papillomatosis 30.6 KRT7 CEACAM5
4 cholangitis, primary sclerosing 30.6 KRT7 KRT19 GPT F2 ALB AFP
5 tubular adenocarcinoma 30.5 KRT7 CEACAM5 AFP
6 liver inflammatory pseudotumor 30.5 CEACAM5 AFP
7 portal hypertension 30.5 GPT F2 ALB
8 obstructive jaundice 30.5 GPT F2 ALB
9 krukenberg carcinoma 30.4 KRT7 CEACAM5
10 cystadenoma 30.4 KRT7 CEACAM5 AFP
11 acute cholangitis 30.4 GPT F2 CEACAM5 ALB
12 neuroendocrine carcinoma 30.3 KRT7 KRT19 CEACAM5
13 paralytic ileus 30.3 GPT F2 ALB
14 biliary atresia 30.3 KRT7 GPT F2 ALB
15 cholecystolithiasis 30.3 GPT CEACAM5
16 bile duct cystadenocarcinoma 30.3 KRT7 CEACAM5 AFP
17 liver sarcoma 30.3 KRT7 CEACAM5 AFP
18 pleural empyema 30.2 GPT F2 ALB
19 hydrocele 30.2 KRT7 KRT19 AFP
20 undifferentiated embryonal sarcoma of the liver 30.2 TP53 MALAT1
21 embryonal sarcoma 30.2 TP53 MALAT1
22 typhoid fever 30.2 GPT F2 ALB
23 choledocholithiasis 30.1 SPATA20 GPT F2 CEACAM5 ALB
24 cholangitis 30.1 GPT F2 CEACAM5 ALB
25 cystadenocarcinoma 30.0 TP53 KRT7 CEACAM5
26 ampulla of vater cancer 29.9 TP53 KRT7 CEACAM5
27 cholecystitis 29.9 TP53 GPT F2 ALB
28 schistosomiasis 29.9 TP53 GPT F2 ALB
29 biliary tract benign neoplasm 29.9 TP53 KRT7 KRT19 CEACAM5 AFP
30 gallbladder cancer 29.9 TP53 MALAT1 KRT7 KRT19 CEACAM5 AFP
31 hepatic tuberculosis 29.8 GPT F2 CEACAM5 ALB AFP
32 liver disease 29.8 KRT19 GPT F2 ALB AFP
33 meckel diverticulum 29.8 KRT7 ALB
34 viral hepatitis 29.8 KRT19 GPT F2 ALB AFP
35 papillary adenocarcinoma 29.7 TP53 KRT7 KRT19 CEACAM5
36 mucinous adenocarcinoma 29.7 TP53 KRT7 KRT19 CEACAM5
37 adenosquamous carcinoma 29.7 TP53 KRT7 KRT19 CEACAM5
38 liver cirrhosis 29.6 TP53 MALAT1 GPT F2 ALB AFP
39 bile duct cancer 29.6 TP53 KRT7 KRT19 GPT CEACAM5 ALB
40 hemangioma 29.5 TP53 KRT7 IDH1 F2
41 hepatitis b 29.5 TP53 GPT F2 ALB AFP
42 cholangiocarcinoma 29.3 TP53 MIR373 MALAT1 KRT7 KRT19 IDH1
43 intrahepatic cholangiocarcinoma 29.2 TP53 KRT7 KRT19 IDH1 CPS1-IT1 ALB
44 lung cancer susceptibility 3 29.1 TP53 MALAT1 KRT7 KRT19 IDH1 CEACAM5
45 bile duct adenocarcinoma 28.9 TP53 KRT7 KRT19 IDH1 CEACAM5 ALB
46 bile duct disease 28.4 TP53 KRT7 KRT19 IDH1 GPT F2
47 biliary tract disease 28.4 TP53 KRT7 KRT19 IDH1 GPT F2
48 hepatocellular carcinoma 28.3 TP53 MALAT1 KRT7 KRT19 IDH1 GPT
49 adenocarcinoma 10.4
50 liver lipoma 10.4 CEACAM5 AFP

Graphical network of the top 20 diseases related to Klatskin's Tumor:



Diseases related to Klatskin's Tumor
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Symptoms & Phenotypes for Klatskin's Tumor

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Human phenotypes related to Klatskin's Tumor:

58 31 (show all 10)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 jaundice 58 31 hallmark (90%) Very frequent (99-80%) HP:0000952
2 extrahepatic cholestasis 58 31 hallmark (90%) Very frequent (99-80%) HP:0012334
3 cholangiocarcinoma 58 31 hallmark (90%) Very frequent (99-80%) HP:0030153
4 hepatomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0002240
5 lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0002716
6 fatigue 58 31 occasional (7.5%) Occasional (29-5%) HP:0012378
7 fever 58 31 occasional (7.5%) Occasional (29-5%) HP:0001945
8 venous thrombosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0004936
9 abdominal pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002027
10 weight loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0001824

UMLS symptoms related to Klatskin's Tumor:


abdominal pain; icterus; malaise
Sources

Drugs & Therapeutics for Klatskin's Tumor

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Drugs for Klatskin's Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 4 154361-50-9 60953
2
Bilirubin Phase 4 635-65-4 5280352
3
Bismuth Phase 4 7440-69-9 16682734 105143
4
Trioxsalen Approved Phase 3 3902-71-4 5585
5 Ether Phase 3
6 Photosensitizing Agents Phase 3
7 Dihematoporphyrin Ether Phase 3
8 Hematoporphyrins Phase 3
9 Dermatologic Agents Phase 3
10 Hematoporphyrin Derivative Phase 3
11
Fluorouracil Approved Phase 2 51-21-8 3385
12
Floxuridine Approved Phase 1, Phase 2 50-91-9 5790
13
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
14
Levoleucovorin Approved, Investigational Phase 2 68538-85-2 149436
15
Trametinib Approved Phase 2 871700-17-3 11707110
16
leucovorin Approved Phase 2 58-05-9 6006
17
Lenvatinib Approved, Investigational Phase 2 417716-92-8
18
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
19
Hydroxychloroquine Approved Phase 2 118-42-3 3652
20
Temoporfin Approved, Investigational Phase 2 122341-38-2
21
Ceritinib Approved Phase 2 1032900-25-6
22
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
23
Tyrosine Approved, Investigational, Nutraceutical Phase 2 60-18-4 6057
24 Immunosuppressive Agents Phase 2
25 Antimetabolites Phase 2
26 Hematinics Phase 2
27
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
28 Micronutrients Phase 2
29 Antidotes Phase 2
30 Trace Elements Phase 2
31 Nutrients Phase 2
32 Folate Phase 2
33 Vitamin B Complex Phase 2
34 Hormones Phase 2
35 Protective Agents Phase 2
36 Vitamin B9 Phase 2
37 Vitamins Phase 2
38 Calcium, Dietary Phase 2
39 Angiogenesis Inhibitors Phase 2
40 Mitogens Phase 2
41 Immunoglobulins Phase 2
42 Antibodies Phase 2
43 Antibodies, Monoclonal Phase 2
44 Endothelial Growth Factors Phase 2
45 Immunologic Factors Phase 1, Phase 2
46 Anti-Infective Agents Phase 2
47 Antineoplastic Agents, Immunological Phase 1, Phase 2
48 Antirheumatic Agents Phase 2
49 Antiparasitic Agents Phase 2
50 Antimalarials Phase 2

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Effect of Preoperative Biliary Drainage on Postoperative Complications in Resectable Patients With Hilar Cholangiocarcinoma(Klatskin Tumor) Unknown status NCT00797121 Phase 4
2 Quality of Life in Patients With Unresectable Hilar Cholangiocarcinoma on Palliative Metallic Stent Versus Plastic Stent: A Randomized Control Trial Unknown status NCT00746538 Phase 4
3 Uncovered Self-expandable Metal Stent Versus DoubleLayer Plastic Stent for Malignant Hilar Stricture: a Prospective Randomized Multicenter Trial Unknown status NCT01125865 Phase 4
4 Efficacy and Cost Analysis of Plastic Stent Compare to Metallic Stent in Unresectable Complex Hilar Cholangiocarcinoma; a Randomized Controlled Trial Completed NCT00721175 Phase 4
5 Liver Transplant Combined With Neoadjuvant Chemo-radiotherapy in the Treatment of Unresectable Hilar Cholangiocarcinoma. A Prospective Multicenter Study. Recruiting NCT04378023 Phase 4 Neoadjuvant Chemo-radiotherapy
6 Percutaneous Bilateral Versus Unilateral Metal Stent Placement for Hilar Cholangiocarcinoma : A Prospective Open-label Randomized Controlled Trial Recruiting NCT02108145 Phase 2, Phase 3
7 Multicenter, Open-label, Randomized, Controlled Phase III Clinical Study of the Efficacy and Safety of Photodynamic Therapy Using Porfimer Sodium for Injection as Treatment for Unresectable Advanced Perihilar Cholangiocarcinoma Terminated NCT02082522 Phase 3 Photodynamic therapy-Photofrin;Chemotherapy regimen
8 Phase 1 Study of Liver Transplantation Combined With Neoadjuvant Radiochemotherapy for Unresectable Hilar Cholangiocarcinoma Unknown status NCT02178280 Phase 1, Phase 2
9 Photodynamic Therapy Using a Novel Photosensitizer in Locally Advanced Hilar Cholangiocarcinoma Unknown status NCT02725073 Phase 2
10 Downstaging of Unresectable Intrahepatic or Hilar Cholangiocellular Carcinoma by Selective Intra-arterial Floxuridine and Systemic Cisplatin and Gemcitabine. A Dose Finding Single Center Phase IIa Study Completed NCT01692704 Phase 1, Phase 2 Selective intra-arterial floxuridine and systemic gemcitabine and cisplatin
11 Phase II Study of Sorafenib (NSC-724772) and Erlotinib (NSC-718781) in Patients With Advanced Gallbladder Carcinoma or Cholangiocarcinoma Completed NCT01093222 Phase 2 Erlotinib Hydrochloride;Sorafenib Tosylate
12 Randomized Phase II Trial of Single Agent MEK Inhibitor Trametinib (GSK1120212) Vs 5-Fluorouracil or Capecitabine in Refractory Advanced Biliary Cancer Completed NCT02042443 Phase 2 Capecitabine;Fluorouracil;Leucovorin Calcium;Trametinib
13 Toripalimab Plus Lenvatinib as Second-line Treatment in Advanced Biliary Tract Cancers: a Single-arm, Non-randomized, Single-center Clinical Trial and Biomarker Study Recruiting NCT04211168 Phase 2 Toripalimab plus Lenvatinib
14 Cholangiocarcinoma Detection Using an Intraoperative Fluorescence Image Guided Approach With Bevacizumab-IRDye 800CW Recruiting NCT03620292 Phase 1, Phase 2 Bevacizumab-IRDye800CW
15 A Phase I/IIA Study of ABC294640 Alone and in Combination With Hydroxychloroquine Sulfate in the Treatment of Patients With Advanced, Unresectable Intra-hepatic, Perihilar and Extra-Hepatic Cholangiocarcinoma Recruiting NCT03377179 Phase 2 ABC294640;Hydroxychloroquine Sulfate 200 MG
16 Safety and Tumoricidal Effect of Low Dose Temoporfin Photodynamic Therapy in Patients With Inoperable Bile Duct Cancers (Foscan® Study) Recruiting NCT03003065 Phase 2 Temoporfin
17 A Phase I/II Study of M3814 and Avelumab in Combination With Hypofractionated Radiation in Patients With Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies Recruiting NCT04068194 Phase 1, Phase 2 Avelumab;Peposertib
18 REGORAFENIB AFTER FAILURE OF GEMCITABINE AND PLATINUM-BASED CHEMOTHERAPY FOR LOCALLY ADVANCED (NON RESECTABLE) AND METASTATIC INTRA-HEPATIC OR HILAR CHOLANGIOCARCINOMA: A Randomized Double-blinded Phase II Trial. Active, not recruiting NCT02162914 Phase 2 Regorafenib/active;Regorafenib/placebo
19 Multi-center, Randomized, Controlled, Open-label Study of Deuteporfin Photodynamic Therapy Plus Stenting Versus Stenting Alone as Treatment for Unresectable Advanced Perihilar Cholangiocarcinoma Terminated NCT02955771 Phase 2
20 A Phase II Trial of LDK378 as the First or Second-line Therapy in ROS1 and /or ALK Over-expressed Advanced Intrahepatic or Hilar Cholangiocarcinoma Terminated NCT02374489 Phase 2 LDK378
21 A Phase I Study of ADH-1 and Gemcitabine Plus Cisplatin in Patients With Unresectable or Metastatic Pancreatic and Biliary Tract Cancers Completed NCT01825603 Phase 1 ADH-1;Cisplatin;Gemcitabine Hydrochloride
22 Phase I Dose Escalation Trial of External Beam Radiation and Cyberknife Radiosurgery Boost With Concurrent Capecitabine for Hilar Cholangiocarcinoma (Klatskin Tumor) Terminated NCT00630890 Phase 1
23 A Phase Ib, Open-Label, Dose- Escalation Trial of ACY-1215 in Combination With Gemcitabine and Cisplatin in Patients With Unresectable or Metastatic Cholangiocarcinoma Withdrawn NCT02856568 Phase 1 Cisplatin;Gemcitabine Hydrochloride;Ricolinostat
24 Trapianto di Fegato Per Colangiocarcinoma (CCA) Ilare in Associazione a Radio e Chemioterapia Neoadiuvante Unknown status NCT01549795 Capecitabine
25 Superior Bilioenteric Anastomosis by Magnetic Compressive Technique: A Multicenter, Prospective, Randomized Controlled Trial Unknown status NCT02801500
26 Impact of Three-dimensional Visualization on Operation Strategy and Complications for Hilar Cholangiocarcinoma Unknown status NCT03132649
27 Exploratory Phase IV Randomized Single Blind Study Evaluating the Efficacy and Tolerability of Hemopatch in Improving Time of Hemostasis and Preventing Post-operative Complications After Hepatic Resection Unknown status NCT03323359
28 Optimization of Health Expenditure in Major Surgery: Impact of a Mixed, Clinical and Ethnographic Approach in the Model of Liver Surgery Unknown status NCT01715402
29 Application of Endoscopic Scissors Cutting Endoscopic Nasobiliary Drainage Tube in the Treatment of Malignant Hilar Biliary Strictures: a Multicenter, Prospective, Randomized Controlled Study Unknown status NCT03353181
30 Effectiveness of Prophylactic Antibiotics to Prevent Post Endoscopic Retrograde Cholangio Pancreatography Bacteremia in Biliary Obstruction Patient Unknown status NCT02958059
31 A Pilot Study to Determine the Feasibility of Stereotactic Body Radiation Therapy Following Chemotherapy for Unresectable Perihilar Cholangiocarcinoma. "The STRONG Trial" Completed NCT03307538
32 Best Biliary Drainage Option in Type II、III、IV Klatskin Tumor：ERCP or PTBD Completed NCT03104582
33 Long-term Morbidity After Surgery for Perihilar Cholangiocarcinoma; a Cohort Study Completed NCT03999593
34 Photodynamic Therapy With Polyhematoporphyrin for Malignant Biliary Obstruction - a Retrospective Analysis. Completed NCT02504957
35 Single Versus Multiple Deployment of Metallic Stents for Inoperable Malignant Hilar Biliary Obstruction: A Multicenter Prospective Randomized Study Completed NCT02166970
36 Split-in-situ Resection With Radio-frequency Ablation Instead of Liver Partition on the First Stage (RALPPS) in Patients With Hilar and Intrahepatic Cholangiocarcinoma Completed NCT03320980
37 Surgical Treatment of Hilar Cholangiocarcinoma: Minor or Major Liver Resection? Completed NCT00733200
38 The Role of Gadoxetate Enhanced Spectral Dual-Energy CT in Evaluating Hilar Cholangiocarcinoma Completed NCT01673802 Early Phase 1 CT scan
39 Preoperative Portal Vein Embolization Using Coils Plus TAGM vs Multiple Coils for Patients With Perihilar Cholangiocarcinoma or Hepatocellular Carcinoma: a Randomized Controlled Study Recruiting NCT04386772
40 Efficacy of Intraductal Radiofrequency Ablation in Combination With Metallic Biliary Stenting in Advanced Hilar Cholangiocarcinoma Recruiting NCT04611100
41 Effect of 37℃ Non-ionic Contrast Agent During ERCP Procedure in Hilar Cholangiocarcinoma: A Prospective Double-blind Multicenter Randomized Controlled Study Recruiting NCT03104569
42 Randomized Clinical Trial Comparing Three Dimension Laparoscopic and Open Surgery for Perihiliar Cholangiocarcinoma Recruiting NCT03383796
43 A Prospective Feasibility Study of Multi-Platform Profiling Using Biospecimens From Patients With Resected Biliary Tract Cancer Recruiting NCT04561453
44 Randomized Prospective Multicentric Study: Radio-chemotherapy and Liver Transplantation Versus Liver Resection to Treat Respectable Hilar Cholangiocarcinoma Active, not recruiting NCT02232932
45 Expanded Access to ABC-108, A Phase IIA Study of ABC294640 in the Treatment of Patients With Advanced,Unresectable Intra-hepatic, Perihilar and Extra-Hepatic Cholangiocarcinoma Available NCT03414489 ABC294640
46 Complete Robotic Tampa Associating Microwave Liver Ablation With Portal Vein Ligation Enrolling by invitation NCT03739164
47 Process Optimization of Preoperative Biliary Drainage in Patients With Malignant Obstructive Jaundice of Extrahepatic Bile Duct: A Multi-center, Prospective, Open-labeled, Real World Study Based on Electronic Data Capture System Not yet recruiting NCT03527875
48 Radiation-Emitting Metallic Stents (REMS) Combined With Trans-Arterial Infusion (TAI) Versus Uncovered Self-Expandable Metallic Stent (SEMS) Combined With Trans-Arterial Infusion (TAI) for Unresectable Hilar Cholangiocarcinoma Not yet recruiting NCT04801160
49 I-125 Seeds Loaded Stent Insertion for Inoperable Hilar Cholangiocarcinoma Not yet recruiting NCT04779788
50 Coregistration of 18F-FDG-PET and MRI in the Staging of Potentially Resectable Hilar Cholangiocarcinoma: a Pilot Study. Withdrawn NCT00604266

Search NIH Clinical Center for Klatskin's Tumor

Cochrane evidence based reviews: klatskin tumor

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Genetic Tests for Klatskin's Tumor

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Sources

Anatomical Context for Klatskin's Tumor

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MalaCards organs/tissues related to Klatskin's Tumor:

40
Liver, Colon, Ovary, Lung, Thyroid, Testis, Appendix
Sources

Publications for Klatskin's Tumor

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Articles related to Klatskin's Tumor:

(show top 50) (show all 294)
# Title Authors PMID Year
1
Methyl-CpG binding protein MBD2 is implicated in methylation-mediated suppression of miR-373 in hilar cholangiocarcinoma. 47
21165562 2011
2
Robotic Resection of a Type IIIB Klatskin Tumor. 61
33728593 2021
3
Multifocal pancreatobiliary malignancies: A diagnostic and therapeutic challenge. 61
33299511 2021
4
Ampullitis Superimposed Obstructive Jaundice in a Patient With COVID-19. 61
33737998 2021
5
Impact of changes in the topographic classification of Klatskin tumor on incidence of intra- and extrahepatic bile duct cancer: A population-based national cancer registry study. 61
33615747 2021
6
Recurrent Cholangiocarcinoma Presenting as Sister Mary Joseph Nodule After Liver Transplantation. 61
33262920 2020
7
Gerald Klatskin (1910-1986): A pioneer in hepato-biliary disorders and biopsy techniques. 61
29998747 2020
8
Liver venous deprivation versus portal vein embolization before major hepatectomy: future liver remnant volumetric and functional changes. 61
33163507 2020
9
Klatskin tumor diagnosed concurrently with IgG4 related sclerosing cholangitis: A case report. 61
32846862 2020
10
There Is a Great Future in Plastics: Personalized Approach to the Management of Hilar Cholangiocarcinoma Using a 3-D-Printed Liver Model. 61
32440740 2020
11
Current status of laparoscopic radical hilar cholangiocarcinoma in Mainland China. 61
32389939 2020
12
A case of peribiliary hepatic cysts in a cirrhotic liver: A mimicker of Klatskin Tumor. 61
32435324 2020
13
Endoscopic Versus Percutaneous Preoperative Biliary Drainage in Patients With Klatskin Tumor Undergoing Curative Surgery: A Systematic Review and Meta-Analysis of Short-Term and Long-Term Outcomes. 61
32172684 2020
14
The Role of Portoenterostomy with Aggressive Hilar Dissection in Biliary Tract Tumors: Report of Case Series and Review of the Literature. 61
32410790 2020
15
Advanced laparoscopic HPB surgery: Experience in Seoul National University Bundang Hospital. 61
32490336 2020
16
Hepatobiliary and pancreatic surgery in the elderly: Current status. 61
32181422 2020
17
A non-klatskin tumor: A case report and review of intrabiliary hydatid cyst rupture. 61
33189007 2020
18
Nomograms predict survival outcome of Klatskin tumors patients. 61
32110489 2020
19
Klatskin-mimicking neuroendocrine tumor. 61
31696723 2019
20
Acute mental change as the presenting sign of posthepatectomy hepatic failure: A case report. 61
31770264 2019
21
Percutaneous Hepaticojejunostomy across an Isolated Bile Duct after Klatskin Tumor Resection. 61
31349977 2019
22
Clinical features of isolated proximal-type immunoglobulin G4-related sclerosing cholangitis. 61
30570170 2019
23
Klatskin Tumor: A Population-Based Study of Incidence and Survival. 61
31204730 2019
24
Heterotopic chondroid tissue of the main bile duct mimicking Klatskin tumor: case report and review of the literature. 61
30499056 2019
25
Radiotherapy or Chemoradiation in Unresectable Biliary Cancer: A Retrospective Study. 61
31177154 2019
26
Liver Transplant for Perihilar Cholangiocarcinoma (Klatskin Tumor): The Essential Role of Patient Selection. 61
29911960 2019
27
Hepatic hilar mass in an adolescent: a rare case of hepatobiliary tuberculosis. 61
30832669 2019
28
Ultrasound-guided percutaneous irreversible electroporation of hepatic and abdominal tumors not eligible for surgery or thermal ablation: a western report on safety and efficacy. 61
30843171 2019
29
Primary large cell neuroendocrine carcinoma of the common hepatic duct mimicking a Klatskin tumor. 61
29466852 2019
30
Klatskin tumors and "Klatskin-mimicking lesions": our 22-year experience. 61
30421957 2019
31
Concomitant adenosquamous carcinoma and cystadenocarcinoma of the extrahepatic bile duct: A case report. 61
30705898 2019
32
Preoperative Portal Vein Embolization Alone with Biliary Drainage Compared to a Combination of Simultaneous Portal Vein, Right Hepatic Vein Embolization and Biliary Drainage in Klatskin Tumor. 61
30238334 2018
33
[Cavernoma complicated with biliopatia secondary to type 1 Gaucher disease: report of a Peruvian case]. 61
30540732 2018
34
Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case Report. 61
28745084 2018
35
IgG4-related sclerosing cholangitis mimicking hilar cholangiocarcinoma (Klatskin tumor): a case report of a challenging disease and review of the literature. 61
31579779 2018
36
Metastatic Pancreatic Adenocarcinoma Presenting as a Klatskin Tumor. 61
30568968 2018
37
Mirizzi Syndrome: Diagnosis and Management of a Challenging Biliary Disease. 61
30159303 2018
38
[Cholangiocellular cancer: the state of the problem and ways to improve the results of surgical treatment]. 61
30560842 2018
39
Klatskin Tumor. 61
28985102 2017
40
Best option for preoperative biliary drainage in Klatskin tumor: A systematic review and meta-analysis. 61
29069029 2017
41
Single synchronous liver metastasis from Merkel cell carcinoma mimicking a klatskin tumor: A diagnostic challenge. 61
28473299 2017
42
Hepatoduodenal lymph node metastasis mimicking Klatskin tumor in a patient with sigmoid colon mucinous cancer. 61
28828110 2017
43
Primary Hepatic Lymphoma Mimicking Cholangiocarcinoma. 61
28804587 2017
44
Preoperative biliary drainage versus direct surgery for perihilar cholangiocarcinoma: A retrospective study at a single center. 61
28529266 2017
45
Primary extrahepatic bile duct neuroendocrine tumor with obstructive jaundice masquerading as a Klatskin tumor. 61
28596824 2017
46
Evaluation of Tumor Markers and Their Impact on Prognosis in Gallbladder, Bile Duct and Cholangiocellular Carcinomas - A Pilot Study. 61
28373474 2017
47
Photodynamic therapy with polyhematoporphyrin for malignant biliary obstruction: A nationwide retrospective study of 150 consecutive applications. 61
28405328 2017
48
Mortality after portal vein embolization: Two case reports. 61
28178122 2017
49
Extrahepatic biliary obstrution secondary to neuroendocrine tumor of the common hepatic duct. 61
27902955 2017
50
Best options for preoperative biliary drainage in patients with Klatskin tumors. 61
27287904 2017
Sources

Variations for Klatskin's Tumor

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ClinVar genetic disease variations for Klatskin's Tumor:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 APC NM_000038.6(APC):c.4658C>T (p.Ala1553Val) SNV Uncertain significance 559953 rs1554086050 GRCh37: 5:112175949-112175949
GRCh38: 5:112840252-112840252
Sources

Expression for Klatskin's Tumor

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Search GEO for disease gene expression data for Klatskin's Tumor.
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Pathways for Klatskin's Tumor

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Pathways related to Klatskin's Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
FOXA2 and FOXA3 transcription factor networks 1
10.44 F2 ALB AFP
Sources

GO Terms for Klatskin's Tumor

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Cellular components related to Klatskin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.23 SLC38A1 KRT7 KRT19 IDH1 GPT F2
Sources

Sources for Klatskin's Tumor

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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