MCID: KLB004
MIFTS: 26

Klebsiella Infection

Categories: Rare diseases

Aliases & Classifications for Klebsiella Infection

MalaCards integrated aliases for Klebsiella Infection:

Name: Klebsiella Infection 53
Klebsiella Infections 73
Klebsiella 53

Classifications:



External Ids:

UMLS 73 C0022729

Summaries for Klebsiella Infection

NIH Rare Diseases : 53 Klebsiella infections refer to several different types of healthcare-associated infections that are all caused by the Klebsiella bacteria, including pneumonia; bloodstream infections; wound or surgical site infections; and meningitis. Healthy people usually do not get Klebsiella infections. However, people who are hospitalized and receiving treatment for other conditions may be susceptible to these infections. In healthcare settings, people who require long courses of antibiotics and/or devices such as ventilators (breathing machines) or intravenous (vein) catheters are at the most risk for Klebsiella infections. These infections are often treated with antibiotics, although some Klebsiella bacteria may be resistant to certain types of antibiotics.

MalaCards based summary : Klebsiella Infection, also known as klebsiella infections, is related to granuloma inguinale and rhinoscleroma. An important gene associated with Klebsiella Infection is WDR26 (WD Repeat Domain 26). The drugs Colistin and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and brain.

Related Diseases for Klebsiella Infection

Diseases related to Klebsiella Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 granuloma inguinale 11.5
2 rhinoscleroma 11.4
3 klebsiella pneumonia 11.2
4 craniosynostosis 1 11.2
5 immunodeficiency 30 11.0
6 keratoconus posticus circumscriptus 10.9
7 cerebrotendinous xanthomatosis 10.7
8 pneumonia 10.7
9 endophthalmitis 10.5
10 meningitis 10.3
11 acute cystitis 10.3
12 fasciitis 10.3
13 necrotizing fasciitis 10.3
14 arthritis 10.3
15 septic arthritis 10.2
16 mastitis 10.1
17 uveitis 10.1
18 anterior uveitis 10.1
19 peritonitis 10.1
20 lung abscess 10.1
21 endocarditis 10.1
22 splenic abscess 10.1
23 diabetes mellitus 10.1
24 osteomyelitis 10.1
25 epidural abscess 10.1
26 pyomyositis 10.1
27 tetralogy of fallot 10.0
28 pyelonephritis 10.0
29 cellulitis 10.0
30 spondyloarthropathy 1 10.0
31 spondylitis 10.0
32 rheumatoid arthritis 10.0
33 polyarteritis nodosa, childhood-onset 10.0
34 diarrhea 10.0
35 bacteriuria 10.0
36 rhinitis 10.0
37 colitis 9.9
38 hypopyon 9.9
39 meningoencephalitis 9.9
40 orbital cellulitis 9.9
41 lemierre's syndrome 9.9
42 gastroenteritis 9.9
43 mediastinitis 9.9
44 diabetic foot ulcers 9.9
45 gas gangrene 9.9
46 neutropenia 9.9
47 ecthyma 9.9
48 cystitis 9.9
49 cholecystitis 9.9
50 thrombophlebitis 9.9

Graphical network of the top 20 diseases related to Klebsiella Infection:



Diseases related to Klebsiella Infection

Symptoms & Phenotypes for Klebsiella Infection

Drugs & Therapeutics for Klebsiella Infection

Drugs for Klebsiella Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 113)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Colistin Approved Phase 4,Phase 3,Not Applicable 1264-72-8, 1066-17-7 5311054
2
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2 55-56-1 2713 9552079
3
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
4
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
5
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 85721-33-1 2764
6
leucovorin Approved Phase 4,Phase 3,Phase 2 58-05-9 6006 143
7
Ertapenem Approved, Investigational Phase 4,Phase 2,Phase 3 153832-46-3 150610
8
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
9
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
10
Cephalexin Approved, Investigational, Vet_approved Phase 4,Phase 2 15686-71-2 27447
11
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
12
Polyestradiol phosphate Approved Phase 4 28014-46-2
13
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
14
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
15 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
16
Tazobactam Approved Phase 4,Phase 3 89786-04-9 123630
17
Piperacillin Approved Phase 4,Phase 3 66258-76-2 43672
18
Meropenem Approved, Investigational Phase 4,Phase 3 119478-56-7 64778 441130
19
Mupirocin Approved, Investigational, Vet_approved Phase 4 12650-69-0 446596
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
21 Polymyxins Phase 4,Phase 3,Not Applicable
22 Gentamicins Phase 4,Not Applicable
23 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
24 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
25 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
26 Antitubercular Agents Phase 4,Not Applicable,Early Phase 1
27 Chlorhexidine gluconate Phase 4,Phase 3,Phase 2
28 Dermatologic Agents Phase 4,Phase 3,Phase 2
29 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Not Applicable
30 methicillin Phase 4
31 Disinfectants Phase 4,Phase 3,Phase 2
32 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
33 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
34 Vitamin B Complex Phase 4,Phase 3,Phase 2
35 Liver Extracts Phase 4
36 Renal Agents Phase 4,Phase 3,Phase 2
37 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
38 Antiprotozoal Agents Phase 4,Phase 2
39 Anti-Infective Agents, Urinary Phase 4,Phase 3,Phase 2
40 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 2
41 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
42 Folate Phase 4,Phase 3,Phase 2
43 Antimalarials Phase 4,Phase 2
44 Vitamin B9 Phase 4,Phase 3,Phase 2
45 Antiparasitic Agents Phase 4,Phase 2
46 Contraceptives, Oral Phase 4
47 Fluoroquinolones Phase 4,Phase 2,Phase 3,Early Phase 1
48 Norgestimate, ethinyl estradiol drug combination Phase 4
49 Estradiol 17 beta-cypionate Phase 4
50 Contraceptive Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 83)
# Name Status NCT ID Phase Drugs
1 SDD for Eradicating CRKP Carriage Unknown status NCT01761487 Phase 4
2 Safety and Efficacy Study of High Dose Colistin Unknown status NCT02162966 Phase 4 High Dose Colistin;Standard Dose Colistin
3 Antibiotics for Klebsiella Liver Abscess Study Completed NCT01723150 Phase 4 Ciprofloxacin;Ceftriaxone;Trimethoprim/sulfamethoxazole;Ertapenem
4 Moxifloxacin Versus Ceftriaxone in the Treatment of Primary Pyogenic Liver Abscess Completed NCT00895089 Phase 4 Moxifloxacin (Avelox);ceftriaxone
5 Clinical and Immunological Efficiency of Bacterial Vaccines at Adult Patients With Bronchopulmonary Pathology Recruiting NCT02787863 Phase 4 Polioxidonium
6 Preventing Recurrent Urinary Tract Infections With α-D-mannose Recruiting NCT03497598 Phase 4 Mannose;Lactose
7 RCT Meropenem vs Piperacillin-Tazobactam for Definitive Treatment of BSI's Due to Ceftriaxone Non-susceptible Escherichia Coli and Klebsiella Spp. Terminated NCT02176122 Phase 4 Meropenem;Piperacillin-tazobactam combination product
8 Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") Terminated NCT00747461 Phase 4
9 Effectiveness of Two Protocols for Corporal Decolonization in Patients Colonized by Methicillin Resistant Staphylococcus Aureus (MRSA) Terminated NCT01400308 Phase 4 Mupirocin + Chlorhexidin
10 Efficacy and Safety of Colistin for Therapy of Infections Caused by ESBL Producing K.Pneumoniae or E.Coli Unknown status NCT00300560 Phase 3 Colistin
11 Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn Unknown status NCT00136370 Phase 3 Chlorhexidine
12 Study Evaluating Tigecycline in Selected Serious Infections Due to Resistant Gram-Negative Organisms Completed NCT00079989 Phase 3 tigecycline
13 Broncho-Vaxom (OM 85 BV) in Children Suffering From Atopic Dermatitis Completed NCT03047954 Phase 3 Broncho-Vaxom;Placebo - Cap
14 A Study to Evaluate Efficacy of Tocilizumab Administered as Monotherapy or in Combination With Methotrexate and/or Other Disease Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis (RA) Participants Completed NCT01941940 Phase 3 Tocilizumab;DMARDs
15 Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and AP Completed NCT02166476 Phase 3 Meropenem-Vaborbactam;Piperacillin-Tazobactam;Levofloxacin;Saline
16 Efficacy Of Bacterial Lysate In Asthmatic Children Completed NCT02541331 Phase 3
17 Trial for the Treatment of Extensively Drug-Resistant Gram-negative Bacilli Recruiting NCT01597973 Phase 3 colistin and meropenem;colistin and placebo
18 Polymyxin B Monotherapy vs Combination Therapy in Critically Ill Patients With Multi-drug Resistant Pathogens Recruiting NCT03159078 Phase 3 Polymyxin B
19 Sitafloxacin and Ertapenem Treatment for Acute Urinary Tract Infection Caused by E. Coli or K. Pneumoniae in Post-kidney Transplantation Patients Active, not recruiting NCT02729116 Phase 2, Phase 3 Sitafloxacin;Ertapenem
20 A Safety and Tolerability Study of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pneumonia Terminated NCT01110421 Phase 3 Cefepime placebo;Cefepime;Doripenem;Doripenem placebo;Amoxicillin/clavulanate potassium
21 Probiotics for Eradication of Carbapenem Resistant Klebsiella Pneumonia Unknown status NCT00722410 Phase 1, Phase 2 Polyethylene glycol
22 Pilot Study of the Effectiveness of Probiotics and Lactitol for the Decolonization of OXA-48 (Carbapenemase) Producing Klebsiella Pneumoniae Among Rectal Carriers Unknown status NCT02307383 Phase 2 Lactitol;Lactobacillus
23 Effect of Improved Oral Hygiene to Prevent Pneumonia in Hospitalized Patients Completed NCT00123123 Phase 2 chlorhexidine gluconate oral rinse (0.12%);placebo
24 Evaluation of Cipro Inhale in Patients With Non-cystic Fibrosis Bronchiectasis Completed NCT00930982 Phase 2 Ciprofloxacin (Cipro, BAYQ3939);Placebo
25 Oral Bacterial Extract for the Prevention of Wheezing Lower Respiratory Tract Illness Recruiting NCT02148796 Phase 2 Broncho-Vaxom
26 The SCOUT Study: "Short Course Therapy for Urinary Tract Infections in Children" Recruiting NCT01595529 Phase 2 Cefixime;Cephalexin;Trimethoprim/Sulfamethoxazole
27 Pentaglobin in CRE and PA Neutropenic Infections Not yet recruiting NCT03494959 Phase 2 Pentaglobin
28 Dosing Study of Cranberry Capsules for the Prevention of Bacteriuria in Nursing Home Residents Completed NCT01033383 Phase 1
29 Single and Multiple Dose Evaluation of QBKPN SSI In Healthy Volunteers Withdrawn NCT02897999 Phase 1
30 Evaluation of a Probiotic (Bifidobacterium in the Treatment of Infantile Colic (IC) Unknown status NCT02988791 Not Applicable
31 A Randomized Trial Comparing Matt and Antimicrobial Cellomed Laminates Unknown status NCT01245829 Not Applicable
32 SATURN 04 Nosocomial Acquisition Study Unknown status NCT01208519
33 Microbiology and Clinical Outcome of Pneumonia Unknown status NCT00873522
34 Feasibility Studies to Inform Novel Proposals to Avert Community-Based Antimicrobial Resistance Spread Unknown status NCT02666274
35 Experimental Phage Therapy of Bacterial Infections Unknown status NCT00945087 Not Applicable
36 Stool Transplantation to Reduce Antibiotic Resistance Transmission Unknown status NCT02461199
37 Group B Streptococcus (GBS) Associated Stillbirths in a High Burden Setting Unknown status NCT02339077
38 Assessing the Effect of Contact Isolation on Nosocomial Colonization With ESBL-EC in German Hematology/Oncology Wards Unknown status NCT02456818
39 The Incidence of Extended-spectrum β-lactamase (ESBL) Klebsiella Pneumonia in Patient on Renal Replacement Therapy Completed NCT01612182
40 A Study Evaluating the Role of Oral Antibiotics in an Aim to Eradicate Carrier State of Carbapenem- Resistant Klebsiella Pneumonia (KPC). Completed NCT01266499 Not Applicable Colistin (Polymyxin E) 100mg x 4/d;both medications;will not receive PO treatment;PO Garamycin 80mg x 4/d
41 Double Carbapenem as Rescue Strategy for the Treatment of Carbapenemase-Producing Klebsiella Pneumoniae Infections Completed NCT03094494
42 Risk Factors for Quinolone Resistance Among ESBL Producing Klebsiella Species Completed NCT00518661
43 Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features Completed NCT01139112
44 Study Evaluating Antibiotic Use in Reducing Vancomycin-Resistant Enterococci and ESBL Producing Escherichia Coli and Klebsiella Pneumoniae in Intensive Care Completed NCT00167986 vancomycin-resistant enterococci and ESBL
45 Efficacy of Intestinal Decontamination in Patients Colonized by Carbapenem-resistant Klebsiella Pneumoniae and Colistin Completed NCT02604849 Neomycin;Streptomycin;Gentamicins
46 Selective Digestive Decontamination in Carriers of Carbapenem-resistant Klebsiella Pneumoniae Completed NCT00753558 Not Applicable Arm #1 :Oral solution and buccal gel of gentamicin and polymyxin E. Arm #2: Placebo.
47 Study Evaluating Piperacillin-Tazobactam on Certain Bacteria in Hematology and Oncology Units Completed NCT00167999 piperacillin-tazobactam
48 Colonization With Extended-Spectrum Beta-Lactamase (ESBL)-Producing Organisms Completed NCT01324726
49 Community - Associated Extended-spectrum Beta-lactamases (ESBL) Completed NCT00363220
50 Community-Onset Bacteremia Due to ESBL Producing E.Coli or K.Pneumoniae in China: Prevalence, Risk Factors and Prognosis Completed NCT01961206

Search NIH Clinical Center for Klebsiella Infection

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Klebsiella Infection

Anatomical Context for Klebsiella Infection

MalaCards organs/tissues related to Klebsiella Infection:

41
Lung, Colon, Brain, Spinal Cord, Prostate, Thyroid, Myeloid

Publications for Klebsiella Infection

Articles related to Klebsiella Infection:

(show top 50) (show all 66)
# Title Authors Year
1
Colistin-Resistant Klebsiella Infections Among Pediatric Oncology and Hematopoietic Stem Cell Transplantation Patients in Eastern India. ( 29173228 )
2018
2
Incidence of Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Infections in the United States: A Systematic Literature Review. ( 28758612 )
2017
3
Newborn with rash due to Klebsiella infection. ( 28012933 )
2016
4
BamB and outer membrane biogenesis - The Achilles' heel for targeting Klebsiella infections? ( 27129024 )
2016
5
Evaluation of virulent multidrug resistant Klebsiella infection status in a tertiary care hospital in Eastern India. ( 23785917 )
2012
6
Intrapulmonary administration of leukotriene B(4) augments neutrophil accumulation and responses in the lung to Klebsiella infection in CXCL1 knockout mice. ( 22379035 )
2012
7
CXCL1 regulates pulmonary host defense to Klebsiella Infection via CXCL2, CXCL5, NF-kappaB, and MAPKs. ( 20937845 )
2010
8
Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection. ( 19846873 )
2009
9
Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. ( 19342674 )
2009
10
Decreased neutrophil response in a model of chronic intraperitoneal Klebsiella infection. ( 17635060 )
2007
11
A possible link between Crohn's disease and ankylosing spondylitis via Klebsiella infections. ( 16941202 )
2007
12
IL-10 in antilipopolysaccharide immunity against systemic Klebsiella infections. ( 17392590 )
2006
13
Proinflammatory cytokines in antilipopolysaccharide immunity against Klebsiella infections. ( 16030391 )
2005
14
CpG oligodeoxynucleotides stimulate protective innate immunity against pulmonary Klebsiella infection. ( 15470059 )
2004
15
STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection. ( 15356157 )
2004
16
O antigen seroepidemiology of Klebsiella clinical isolates and implications for immunoprophylaxis of Klebsiella infections. ( 15040933 )
2004
17
Klebsiella infection in patients with thalassemia. ( 12594637 )
2003
18
Nosocomial Klebsiella infection in neonates in a tertiary care hospital: protein profile by SDS-page and klebocin typing as epidemiological markers. ( 17642987 )
2003
19
Klebsiella infections in the immunocompromised host. ( 10897425 )
2000
20
Exogenous cytokine modulation or neutralization of interleukin-10 enhance survival in lipopolysaccharide-hyporesponsive C3H/HeJ mice with Klebsiella infection. ( 10469238 )
1999
21
Hyperammonaemia due to Klebsiella infection in a neuropathic bladder. ( 9811390 )
1998
22
Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection. ( 9125558 )
1997
23
Clinical, bacteriological, and serological aspects of Klebsiella infections and their spondylarthropathic sequelae. ( 9220153 )
1997
24
O-antigen seroepidemiology of Klebsiella clinical isolates and implications for immunoprophylaxis of Klebsiella infections. ( 9302204 )
1997
25
Severe Klebsiella infection as a cause of mortality in neonates in Harare, Zimbabwe: evidence from postmortem blood cultures. ( 8284121 )
1993
26
Nosocomial outbreak of Klebsiella infection resistant to late-generation cephalosporins. ( 8135915 )
1993
27
Epidemiological analysis of Klebsiella infections at a neonate department. ( 1512448 )
1992
28
The relationship between Klebsiella infection and ankylosing spondylitis. ( 2670258 )
1989
29
Serum immunoglobulin levels in patients with active pulmonary tuberculosis and patients with Klebsiella infection. ( 3623633 )
1987
30
An outbreak of serious Klebsiella infections related to food blenders. ( 2883228 )
1987
31
The sera of patients with Klebsiella infections contain a common anti-DNA idiotype (16/6) Id and anti-polynucleotide activity. ( 3301096 )
1987
32
Klebsiella infection in a neonatal intensive care unit. ( 6397862 )
1984
33
Klebsiella infection in a neonatal intensive care unit: role of bacteriological surveillance. ( 6085092 )
1984
34
Klebsiella-induced LIF response in Klebsiella infection and ankylosing spondylitis. ( 6360292 )
1983
35
Experimental model of Klebsiella infection in mice for studies on mechanisms of local immunity of the respiratory tract. ( 6357970 )
1983
36
Progress in immunization against Klebsiella infections. ( 6365535 )
1983
37
Amelioration by muramyl dipeptide of the effect of induced hyperferremia upon Klebsiella infection in mice. ( 6754611 )
1982
38
Fate of two 14C labelled muramyl peptides: Ac-Mur-L-Ala-gamma-D-Glu-meso-A2pm and Ac-Mur-L-Ala-gamma-D-Glu-meso-A2pm-D-Ala-D-Ala in mice. Evaluation of their ability to increase non specific resistance to Klebsiella infection. ( 7049971 )
1982
39
Veterinary nosocomial (hospital-acquired) Klebsiella infections. ( 7341571 )
1981
40
Nosocomial klebsiella infection in a neonatal unit: identification of risk factors for gastrointestinal colonization. ( 7005139 )
1980
41
Epidemiological study of klebsiella infection in the special care baby unit of a London hospital. ( 7400339 )
1980
42
An investigation into the incidence and sources of klebsiella infections in hospital patients. ( 376698 )
1979
43
Klebsiella infections in mares. ( 516337 )
1979
44
The use of a fluorescence typing method in an epidemiological study of Klebsiella infection in a London hospital. ( 340582 )
1978
45
Enhancement of the neonate's nonspecific immunity to Klebsiella infection by muramyl dipeptide, a synthetic immunoadjuvant. ( 356054 )
1978
46
Microbial iron-chelators and their action on Klebsiella infections in the skin of guinea-pigs. ( 350255 )
1978
47
Gentamicin-resistant Klebsiella infections in a neonatal intensive care unit. ( 645665 )
1978
48
Comparison of bacteriophage typing, serotyping, and biotyping as aids in epidemiological surveillance of Klebsiella infections. ( 744797 )
1978
49
Bladder response to klebsiella infection: a scanning electron microscopy study. ( 338544 )
1977
50
Nosocomial Klebsiella infections in an intensive care nursery. ( 320669 )
1977

Variations for Klebsiella Infection

Expression for Klebsiella Infection

Search GEO for disease gene expression data for Klebsiella Infection.

Pathways for Klebsiella Infection

GO Terms for Klebsiella Infection

Sources for Klebsiella Infection

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