MCID: KLB004
MIFTS: 26

Klebsiella Infection

Categories: Rare diseases

Aliases & Classifications for Klebsiella Infection

MalaCards integrated aliases for Klebsiella Infection:

Name: Klebsiella Infection 20
Klebsiella Infections 71
Klebsiella 20

Classifications:



External Ids:

UMLS 71 C0022729

Summaries for Klebsiella Infection

GARD : 20 Klebsiella is a type of bacteria commonly found in nature. In humans, the bacteria are often present in parts of the digestive tract where they do not generally cause problems. In the United States, Klebsiella pneumoniae and Klebsiella oxytoca are the two strains responsible for most human illnesses. Many Klebsiella infections are acquired in the hospital setting or in long-term care facilities. In fact, Klebsiellae account for up to 8% of all hospital-acquired infections. People with a compromised immune system and/or people who have an implanted medical device (such as a urinary catheter or airway tube) are more at risk for Klebsiella infections. Extensive use of antibiotics has resulted in the development of antibiotic-resistant strains of Klebsiella. These infections can be more aggressive and difficult to treat.

MalaCards based summary : Klebsiella Infection, also known as klebsiella infections, is related to klebsiella pneumonia and granuloma inguinale. An important gene associated with Klebsiella Infection is LCN2 (Lipocalin 2). The drugs Levoleucovorin and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include liver, neutrophil and bone marrow.

Related Diseases for Klebsiella Infection

Diseases related to Klebsiella Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 492)
# Related Disease Score Top Affiliating Genes
1 klebsiella pneumonia 11.7
2 granuloma inguinale 11.1
3 rhinoscleroma 11.0
4 immunodeficiency 30 10.9
5 48,xyyy 10.8
6 acute cystitis 10.8
7 pneumonia 10.8
8 endophthalmitis 10.8
9 meningitis 10.7
10 toxic shock syndrome 10.7
11 mastitis 10.5
12 osteomyelitis 10.5
13 endocarditis 10.5
14 disease by infectious agent 10.4
15 fasciitis 10.4
16 necrotizing fasciitis 10.4
17 colitis 10.4
18 uveitis 10.3
19 septic arthritis 10.3
20 bacteriuria 10.3
21 47,xyy 10.3
22 bacterial meningitis 10.3
23 neutropenia 10.3
24 cystitis 10.3
25 enterocolitis 10.3
26 disseminated intravascular coagulation 10.3
27 rhinitis 10.3
28 infective endocarditis 10.3
29 cellulitis 10.3
30 iridocyclitis 10.3
31 lung abscess 10.2
32 hypopyon 10.2
33 respiratory failure 10.2
34 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
35 bacteremia 2 10.2
36 haemophilus influenzae 10.2
37 pleural empyema 10.2
38 otitis media 10.2
39 helix syndrome 10.2
40 thrombophlebitis 10.2
41 atrophic rhinitis 10.2
42 overgrowth syndrome 10.2
43 alcohol dependence 10.2
44 bronchopneumonia 10.2
45 keratitis, hereditary 10.2
46 liver cirrhosis 10.2
47 meningoencephalitis 10.1
48 epidural abscess 10.1
49 gastroenteritis 10.1
50 splenic abscess 10.1

Graphical network of the top 20 diseases related to Klebsiella Infection:



Diseases related to Klebsiella Infection

Symptoms & Phenotypes for Klebsiella Infection

Drugs & Therapeutics for Klebsiella Infection

Drugs for Klebsiella Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
2
Sulfamethoxazole Approved Phase 4 723-46-6 5329
3
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
4
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
5
Colistin Approved Phase 4 1066-17-7, 1264-72-8 5311054
6
Polymyxin B Approved, Vet_approved Phase 4 1404-26-8
7
Tigecycline Approved Phase 4 220620-09-7 5282044
8
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
9
Meropenem Approved, Investigational Phase 4 96036-03-2, 119478-56-7 64778 441130
10
Tazobactam Approved Phase 4 89786-04-9 123630
11
Piperacillin Approved Phase 4 66258-76-2 43672
12
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
13
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
14 Liver Extracts Phase 4
15 Cytochrome P-450 Enzyme Inhibitors Phase 4
16 Folic Acid Antagonists Phase 4
17 Vitamin B Complex Phase 4
18 Antiparasitic Agents Phase 4
19 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
20 Antiprotozoal Agents Phase 4
21 Vitamin B9 Phase 4
22 Antimalarials Phase 4
23 Folate Phase 4
24 Polymyxins Phase 4
25 Pharmaceutical Solutions Phase 4
26 Anti-Infective Agents Phase 4
27 Anti-Bacterial Agents Phase 4
28 Piperacillin, Tazobactam Drug Combination Phase 4
29 beta-Lactamase Inhibitors Phase 4
30 Sitafloxacin Experimental, Investigational Phase 2, Phase 3 163253-35-8
31 Immunologic Factors Phase 3
32 Broncho-Vaxom Phase 3
33 Immunoglobulin E Phase 3
34 Immunoglobulins Phase 3
35 Immunoglobulins, Intravenous Phase 3
36 Antibodies Phase 3
37
Lactitol Approved, Investigational Phase 2 585-86-4 157355
38 Cathartics Phase 2
39 Acidophilus Phase 2
40 Gastrointestinal Agents Phase 2
41 Laxatives Phase 2
42
Neomycin Approved, Vet_approved 1404-04-2 8378
43
Streptomycin Approved, Vet_approved 57-92-1 19649
44
Vancomycin Approved 1404-90-6 441141 14969
45
Mineral oil Approved, Vet_approved 8042-47-5
46
Fosfomycin Approved Early Phase 1 23155-02-4 446987
47
Imipenem Approved 64221-86-9, 74431-23-5 104838
48 Gentamicins
49 Carboxymethylcellulose Sodium
50 Anesthetics

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 SELECTIVE DIGESTIVE DECONTAMINATION USING ORAL GENTAMICIN AND ORAL POLYMYXIN E FOR ERADICATION OF CARBAPENEM-RESISTANT KLEBSIELLA PNEUMONIAE CARRIAGE IN HOSPITALIZED PATIENTS Unknown status NCT01761487 Phase 4
2 A Multi-centre Randomised Open-label Active Comparator-controlled Non-inferiority Trial Comparing Oral to Intravenous Antibiotics in the Early Management of Klebsiella Pneumoniae Liver Abscess Completed NCT01723150 Phase 4 Ciprofloxacin;Ceftriaxone;Trimethoprim/sulfamethoxazole;Ertapenem
3 Comparative Clinical Study Between Colistin-Tigecycline Combined Therapy Versus Colistin-Meropenem Combined Therapy in Treatment of Blood Stream Infections With Multidrug-Resistant Klebsiella Pneumoniae Recruiting NCT04489459 Phase 4 Colistin;Meropenem;Tigecycline
4 Piperacillin/Tazobactam Versus Carbapenems in Non-bacteremic Urinary Tract Infections Due to Extended-spectrum β-lactamase (ESBL)-Producing Escherichia Coli or Klebsiella Pneumoniae - (CAPITIS Study) Recruiting NCT03891433 Phase 4 Meropenem;Ertapenem 1000 MG;Piperacillin, Tazobactam 4-0.5G Solution for Injection
5 Randomized Controlled Trial of Meropenem Versus Piperacillin-Tazobactam for Definitive Treatment of Bloodstream Infections Due to Ceftriaxone Non-susceptible E. Coli and Klebsiella Species. Terminated NCT02176122 Phase 4 Meropenem;Piperacillin-tazobactam combination product
6 Efficacy and Safety of Colistin for Therapy of Infections Caused by Extended Spectrum Beta-Lactamase(ESBL) Producing Klebsiella Pneumoniae or Escherichia Coli Unknown status NCT00300560 Phase 3 Colistin
7 The Effect of Polyvalent Mechanical Bacterial Lysate on the Reduction of Nasal Staphylococcus Aureus Carriage in Children With Pollen Allergic Rhinitis Completed NCT04637425 Phase 3 Ismigen;Placebo
8 The Effect Of Polivalent Mechanical Bacterial Lysate On The Clinical Course Of Grass Pollen-Induced Allergic Rhinitis In Children Completed NCT04270552 Phase 3 Ismigen;Placebo
9 Multicentre, Randomised, Double Blind, Placebo-controlled Study of the Efficacy and Safety of Broncho-Vaxom (OM 85 BV) in Children Suffering From Atopic Dermatitis Completed NCT03047954 Phase 3 Broncho-Vaxom;Placebo - Cap
10 A Phase 3, Open-label, Noncomparative Study of Tigecycline for the Treatment of Subjects With Selected Serious Infections Due to Resistant Gram-negative Organisms Such as Enterobacter Species, Acinetobacter Baumannii, and Klebsiella Pneumoniae Completed NCT00079989 Phase 3 tigecycline
11 Sitafloxacin and Ertapenem Treatment for Acute Urinary Tract Infection Caused by E. Coli or K. Pneumoniae in Post-kidney Transplantation Patients Recruiting NCT02729116 Phase 2, Phase 3 Sitafloxacin;Ertapenem
12 Safety and Efficacy Study of Eradication of Carbapenem Resistant Klebsiella Pneumonia From the Gastrointestinal Tract by Probiotics. Unknown status NCT00722410 Phase 1, Phase 2 Polyethylene glycol
13 Pilot Study of the Effectiveness of Probiotics and Lactitol for the Intestinal Decolonization of People Carriers of Klebsiella Pneumoniae Producers of Carbapenemase OXA-48-type: DesProbiOXA Study Unknown status NCT02307383 Phase 2 Lactitol;Lactobacillus
14 A Placebo-Controlled, Blinded, Dose-Escalation, Study to Assess the Safety and Pharmacodynamics of Single and Multiple Doses of QBKPN (Inactivated Klebsiella Pneumoniae) Site Specific Immunomodulator (SSI), Administered Subcutaneously to Healthy Male and Female Volunteers Withdrawn NCT02897999 Phase 1
15 Klebsiella Pneumoniae Infection in China: Epidemiology, Molecular Characteristics, Treatment, and Outcome Unknown status NCT03598543
16 Epidemiological Characteristics and Treatment Protocol for Carbapenem-Resistant Klebsiella Pneumoniae in China Unknown status NCT03245632
17 Experimental Phage Therapy of Drug-resistant Bacterial Infections, Including MRSA Infections Unknown status NCT00945087
18 Turkish Prospective Cohort Study on Carbapenem Resistant Klebsiella Pneumonia Bacteremia: a National Multicenter Observational Study Completed NCT03597841 Combination therapy
19 A Randomized Open Label Study Evaluating the Role of Oral Antibiotics in an Aim to Eradicate Carrier State of Carbapenem- Resistant Klebsiella Pneumonia (KPC). Completed NCT01266499 Colistin (Polymyxin E) 100mg x 4/d;both medications;will not receive PO treatment;PO Garamycin 80mg x 4/d
20 Efficacy of Intestinal Decontamination in Patients Colonized by Carbapenem-resistant Klebsiella Pneumoniae and Colistin Completed NCT02604849 Neomycin;Streptomycin;Gentamicins
21 Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features Completed NCT01139112
22 Community - Associated Extended-spectrum Beta-lactamases (ESBL) Completed NCT00363220
23 Antibiotic Intervention Trial in a Medical Intensive Care Unit to Reduce the Acquisition of Vancomycin-Resistant Enterococci and ESBL Producing Escherichia Coli and Klebsiella Pneumoniae. Completed NCT00167986 vancomycin-resistant enterococci and ESBL
24 Effects of Piperacillin-Tazobactam Use on the Prevalence Rate of Extended-Spectrum Beta-Lactamase (ESBL) Producing Escherichia Coli and Klebsiella Pneumoniae in Hematology and Oncology Units. Completed NCT00167999 piperacillin-tazobactam
25 Sites of Colonization in Hospitalized Patients With Infections Caused by Extended-Spectrum Beta-Lactamase Producing Escherichia Coli and Klebsiella Pneumoniae Completed NCT01324726
26 Risk Factors for Quinolone Resistance Among Extended-Spectrum Beta-Lactamase-Producing Klebsiella Species Completed NCT00518661
27 Double Carbapenem as Rescue Strategy for the Treatment of Severe Carbapenemase-Producing Klebsiella Pneumoniae Infections: A Two-Center Matched Case-Control Study Completed NCT03094494
28 Community-Onset Bacteremia Due to Extended-Spectrum β-Lactamase (ESBL)Producing Escherichia Coli or Klebsiella Pneumoniae in China: Prevalence, Risk Factors and Prognosis Completed NCT01961206
29 A Randomized,Double-Blind,Placebo-Controled Trial of Selective Digestive Decontamination Using Oral Gentamicin and Oral Polymyxin E for Eradication of Carbapenem-Resistant Klebsiella Pneumoniae Carriage Completed NCT00753558 Arm #1 :Oral solution and buccal gel of gentamicin and polymyxin E. Arm #2: Placebo.
30 Antimicrobial Resistance Rate In Escherichia Coli And Klebsiella Pneumonia : A Retrospective Study Completed NCT04196387
31 The Incidence of Extended-spectrum β-lactamase (ESBL) Klebsiella Pneumonia in Patient on Renal Replacement Therapy Completed NCT01612182
32 Analysis of the Clinical Characteristics for the Critical Ill Patients With Klebsiella Pneumoniae Infection: A Multi-center Research in the Intensive Care Units Completed NCT04404582
33 WGS-guided Tracking and Infection Control Measures of Carbapenem-resistant Klebsiella Pneumoniae Recruiting NCT04413305
34 Genetic Characterization of Plasmids Carrying Carbapenemases and Quinolone Resistance Determinants in Klebsiella Pneumoniae Isolates in Assiut University Hospitals Recruiting NCT03767283
35 How to Optimize the Combined Antibiotic Therapy for Carbapenem Resistant Klebsiella Pneumoniae Recruiting NCT03950544 Early Phase 1 Fosfomycin;Tigecycline;Polymyxin B
36 Reducing Intraoperative ESKAPE (Enterococcus, S. Aureus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter Spp.) Transmission In the Pediatric Operating Room Via Use of a Personal Hand Hygiene System Optimized by OR PathTrac Recruiting NCT03992209
37 Epidemiological, Clinical, Microbiological and Outcome Description of Patients With Klebsiella sp Meningitis Active, not recruiting NCT03967210
38 Understanding and Modelling Reservoirs, Vehicles and Transmission of ESBL-producing Enterobacteriaceae in the Community and Long Term Care Facilities Enrolling by invitation NCT03477084
39 Analysis on the Infection Risk, Prognosis, and Drug Sensitivity of Klebsiella Pneumoniae. Not yet recruiting NCT04337840
40 Comparison of Clinical Outcomes in Bloodstream Infections With Carbapenem Hetero-resistant vs Carbapenem Resistant Klebsiella Pneumoniae (COMBAT) Not yet recruiting NCT04229498 Monotherapy and combination therapy (all antibiotics that are given by attending pysicians and can be active against Klebsiella pneumoniae will be evaluated)
41 Randomized Controlled Trial (RCT) Comparing Microbiome-driven Embryo Transfer (mET) by EMMA/ALICE Test vs Conventional Frozen Embryo Transfer (FET) of Euploid Blastocysts in Infertile Women at Their First IVF/ICSI Cycle Not yet recruiting NCT04686357
42 Oral and Tracheal Cultures in Pediatric ICU Patients Compared to Healthy Children Not yet recruiting NCT03418272

Search NIH Clinical Center for Klebsiella Infection

Inferred drug relations via UMLS 71 / NDF-RT 51 :


cefditoren
CEFTIBUTEN DIHYDRATE
Ciprofloxacin
Enoxacin
lomefloxacin

Genetic Tests for Klebsiella Infection

Anatomical Context for Klebsiella Infection

MalaCards organs/tissues related to Klebsiella Infection:

40
Liver, Neutrophil, Bone Marrow, Spinal Cord

Publications for Klebsiella Infection

Articles related to Klebsiella Infection:

(show top 50) (show all 195)
# Title Authors PMID Year
1
Handwashing Sink Contamination and Carbapenem-resistant Klebsiella Infection in the Intensive Care Unit: A Prospective Multicenter Study. 61
33367578 2020
2
Human Placental MSC-Secreted IL-1β Enhances Neutrophil Bactericidal Functions during Hypervirulent Klebsiella Infection. 61
32997996 2020
3
Mucoviscous characteristics of Klebsiella pneumoniae strains: A factor of clinical severity? 61
31257062 2020
4
Development and evaluation of a new recombinant protein vaccine (YidR) against Klebsiella pneumoniae infection. 61
32444194 2020
5
Efflux pump activity, biofilm formation and antibiotic resistance profile of Klebsiella spp. isolated from clinical samples at Lagos University Teaching Hospital. 61
32456668 2020
6
Detection of multiple hypervirulent Klebsiella pneumoniae strains in a New York City hospital through screening of virulence genes. 61
32461145 2020
7
Elevated urinary IL-1β levels in multidrug resistant Escherichia coli and Klebsiella infections. 61
31820023 2020
8
Could platelet to leucocytic count ratio (PLR) predict sepsis and clinical outcomes in patients with emphysematous pyelonephritis? 61
31103341 2019
9
Diversity of clonal types of Klebsiella pneumoniae causing infections in intensive care neonatal patients in a large urban setting. 61
31401781 2019
10
Klebsiella pneumoniae infection biology: living to counteract host defences. 61
30452654 2019
11
Sphenoid Sinus Cholesteatoma-Complications and Skull Base Osteomyelitis: Case Report and Review of Literature. 61
30858746 2019
12
Colistin-Resistant Klebsiella Infections Among Pediatric Oncology and Hematopoietic Stem Cell Transplantation Patients in Eastern India. 61
29173228 2018
13
Incidence of Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Infections in the United States: A Systematic Literature Review. 61
28758612 2017
14
Combination Therapy for Multidrug-Resistant Klebsiella Pneumoniae Urinary Tract Infection. 61
28948123 2017
15
Alcohol-associated intestinal dysbiosis impairs pulmonary host defense against Klebsiella pneumoniae. 61
28604843 2017
16
Mincle-Mediated Neutrophil Extracellular Trap Formation by Regulation of Autophagy. 61
28186242 2017
17
Newborn with rash due to Klebsiella infection. 61
28012933 2017
18
Oral fosfomycin for treatment of urinary tract infection: a retrospective cohort study. 61
27729016 2016
19
Ozena in Immigrants of Differing Backgrounds. 61
27114295 2016
20
BamB and outer membrane biogenesis - The Achilles' heel for targeting Klebsiella infections? 61
27129024 2016
21
Uncommon cause of acute encephalopathy in liver cirrhosis. 61
27194673 2016
22
A Comparative Study on Antibiotic Resistance of Klebsiella Strains from Surgical and Intensive Care Wards. 61
30568829 2016
23
Epidemiology and Virulence of Klebsiella pneumoniae. 61
26999397 2016
24
Deciphering tissue-induced Klebsiella pneumoniae lipid A structure. 61
26578797 2015
25
Vaccination with Klebsiella pneumoniae-derived extracellular vesicles protects against bacteria-induced lethality via both humoral and cellular immunity. 61
26358222 2015
26
Prevalence of two multidrug-resistant Klebsiella species in an Indian teaching hospital and adjoining community. 61
24996691 2014
27
Multi-drug carbapenem-resistant Klebsiella pneumoniae infection carrying the OXA-48 gene and showing variations in outer membrane protein 36 causing an outbreak in a tertiary care hospital in Riyadh, Saudi Arabia. 61
25245001 2014
28
Antibiotic-loaded cement spacer for treatment of Klebsiella infected total hip and knee arthroplasty. 61
25518276 2014
29
Hypermucoviscous Klebsiella syndrome without liver abscess in a patient with immunoglobulin g2 immune deficiency. 61
25734148 2014
30
Klebsiella pneumoniae Infection: A Virulent Cause of Visual Loss. 61
25606041 2014
31
[Frequency of occurrence of ivyC and pliC lysozyme inhibitors genes in clinical klebsiella strains]. 61
25286520 2014
32
Microbiological and Genetic Characterization of Carbapenem-Resistant Klebsiella pneumoniae Isolated From Pediatric Patients. 61
24567846 2014
33
[Effects of PM2.5 exposure on Klebsiella pneumoniae clearance in the lungs of rats]. 61
24507396 2013
34
Detection of magA Gene in Klebsiella spp. Isolated from Clinical SamplesDetection of magA. 61
24298386 2013
35
The emergence of Klebsiella pneumoniae endogenous endophthalmitis in the USA: basic and clinical advances. 61
23514342 2013
36
Antimicrobial sensitivity patterns of cerebrospinal fluid (CSF) isolates in Namibia: implications for empirical antibiotic treatment of meningitis. 61
24764539 2013
37
Bacterial isolates and its antibiotic susceptibility pattern in NICU. 61
23774417 2013
38
Evaluation of virulent multidrug resistant Klebsiella infection status in a tertiary care hospital in Eastern India. 61
23785917 2012
39
Incidence, aetiology and resistance of late-onset neonatal sepsis: a five-year prospective study. 61
22404730 2012
40
Intrapulmonary administration of leukotriene B(4) augments neutrophil accumulation and responses in the lung to Klebsiella infection in CXCL1 knockout mice. 61
22379035 2012
41
Development of a new trend conjugate vaccine for the prevention of Klebsiella pneumoniae. 61
24470947 2012
42
CXCL1 regulates pulmonary host defense to Klebsiella Infection via CXCL2, CXCL5, NF-kappaB, and MAPKs. 61
20937845 2010
43
Clinical disease caused by Klebsiella in 2 unrelated patients with interleukin 12 receptor beta1 deficiency. 61
20855390 2010
44
Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection. 61
19846873 2009
45
Fatal cross infection by carbapenem-resistant Klebsiella in two liver transplant recipients. 61
19254325 2009
46
Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. 61
19342674 2009
47
[Choice of probiotic for rational therapy of infection caused by Klebsiella in children]. 61
19462517 2009
48
Causative agents and antimicrobial susceptibilities of urinary tract infections in the northwest of Iran. 61
18703368 2009
49
Effects of chelators (deferoxamine, deferiprone and deferasirox) on the growth of Klebsiella pneumoniae and Aeromonas hydrophila isolated from transfusion-dependent thalassemia patients. 61
19814682 2009
50
Outcome of gram negative infection in immunocompromised children. 61
18493995 2008

Variations for Klebsiella Infection

Expression for Klebsiella Infection

Search GEO for disease gene expression data for Klebsiella Infection.

Pathways for Klebsiella Infection

GO Terms for Klebsiella Infection

Sources for Klebsiella Infection

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
17 EFO
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19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
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44 MeSH
45 MESH via Orphanet
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51 NDF-RT
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56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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