MCID: KLB004
MIFTS: 30

Klebsiella Infection

Categories: Rare diseases

Aliases & Classifications for Klebsiella Infection

MalaCards integrated aliases for Klebsiella Infection:

Name: Klebsiella Infection 54
Klebsiella Infections 74
Klebsiella 54

Classifications:



External Ids:

UMLS 74 C0022729

Summaries for Klebsiella Infection

NIH Rare Diseases : 54 Klebsiella is a type of bacteria commonly found in nature. In humans, the bacteria are often present in parts of the digestive tract where they do not generally cause problems. In the United States, Klebsiella pneumoniae and Klebsiella oxytoca are the two strains responsible for most human illnesses. Many Klebsiella infections are acquired in the hospital setting or in long-term care facilities. In fact, Klebsiellae account for up to 8% of all hospital-acquired infections. People with a compromised immune system and/or people who have an implanted medical device (such as a urinary catheter or airway tube) are more at risk for Klebsiella infections. Extensive use of antibiotics has resulted in the development of antibiotic-resistant strains of Klebsiella. These infections can be more aggressive and difficult to treat.

MalaCards based summary : Klebsiella Infection, also known as klebsiella infections, is related to klebsiella pneumonia and granuloma inguinale. An important gene associated with Klebsiella Infection is WDR26 (WD Repeat Domain 26). The drugs Colistin and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and kidney.

Related Diseases for Klebsiella Infection

Diseases related to Klebsiella Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 242)
# Related Disease Score Top Affiliating Genes
1 klebsiella pneumonia 11.8
2 granuloma inguinale 11.5
3 rhinoscleroma 11.4
4 craniosynostosis 1 11.2
5 immunodeficiency 30 11.1
6 keratoconus posticus circumscriptus 11.0
7 cerebrotendinous xanthomatosis 10.8
8 pneumonia 10.8
9 endophthalmitis 10.6
10 meningitis 10.5
11 acute cystitis 10.4
12 fasciitis 10.3
13 arthritis 10.3
14 necrotizing fasciitis 10.3
15 septic arthritis 10.3
16 tetralogy of fallot 10.3
17 peritonitis 10.3
18 osteomyelitis 10.2
19 mastitis 10.2
20 endocarditis 10.2
21 burns 10.2
22 blood group, colton system 10.2
23 diabetes mellitus 10.2
24 anterior uveitis 10.2
25 uveitis 10.1
26 diarrhea 10.1
27 cellulitis 10.1
28 enterocolitis 10.1
29 lung abscess 10.1
30 pyelonephritis 10.1
31 cystitis 10.1
32 splenic abscess 10.1
33 aplasia cutis congenita, nonsyndromic 10.1
34 colitis 10.1
35 epidural abscess 10.1
36 pyomyositis 10.1
37 rheumatoid arthritis 10.0
38 pleural empyema 10.0
39 spondyloarthropathy 1 10.0
40 spondylitis 10.0
41 leukemia 10.0
42 neutropenia 10.0
43 bacteriuria 10.0
44 rhinitis 10.0
45 neutrophil actin dysfunction 9.9
46 spinal cord injury 9.9
47 bacterial infectious disease 9.9
48 hypopyon 9.9
49 meningoencephalitis 9.9
50 orbital cellulitis 9.9

Graphical network of the top 20 diseases related to Klebsiella Infection:



Diseases related to Klebsiella Infection

Symptoms & Phenotypes for Klebsiella Infection

Drugs & Therapeutics for Klebsiella Infection

Drugs for Klebsiella Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 113)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Colistin Approved Phase 4,Phase 3,Not Applicable 1066-17-7, 1264-72-8 5311054
2
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2 55-56-1 2713 9552079
3
Ertapenem Approved, Investigational Phase 4,Phase 2,Phase 3 153832-46-3 150610
4
leucovorin Approved Phase 4,Phase 3,Phase 2 58-05-9 143 6006
5
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
6
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
7
Ceftriaxone Approved Phase 4,Not Applicable 73384-59-5 5479530 5361919
8
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 85721-33-1 2764
9
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
10
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
11
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
12
Polyestradiol phosphate Approved Phase 4 28014-46-2
13
Cephalexin Approved, Investigational, Vet_approved Phase 4,Phase 2 15686-71-2 27447
14
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
15
Piperacillin Approved Phase 4,Phase 3 66258-76-2 43672
16
Tazobactam Approved Phase 4,Phase 3 89786-04-9 123630
17
Meropenem Approved, Investigational Phase 4,Phase 3,Early Phase 1 119478-56-7, 96036-03-2 441130 64778
18
Mupirocin Approved, Investigational, Vet_approved Phase 4 12650-69-0 446596
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
20 Gentamicins Phase 4,Not Applicable
21 Polymyxins Phase 4,Phase 3,Not Applicable,Early Phase 1
22 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
23 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
24 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
25 Antitubercular Agents Phase 4,Not Applicable,Early Phase 1
26 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
27 Dermatologic Agents Phase 4,Phase 3,Phase 2
28 Disinfectants Phase 4,Phase 3,Phase 2
29 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Not Applicable
30 methicillin Phase 4
31 Chlorhexidine gluconate Phase 4,Phase 3,Phase 2
32 Antiprotozoal Agents Phase 4,Phase 2
33 Vitamin B Complex Phase 4,Phase 3,Phase 2
34 Folate Phase 4,Phase 3,Phase 2
35 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 2
36 Anti-Infective Agents, Urinary Phase 4,Phase 3,Phase 2
37 Vitamin B9 Phase 4,Phase 3,Phase 2
38 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
39 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
40 Antimalarials Phase 4,Phase 2
41 Antiparasitic Agents Phase 4,Phase 2
42 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
43 Liver Extracts Phase 4
44 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
45 Renal Agents Phase 4,Phase 3,Phase 2
46 Norgestimate, ethinyl estradiol drug combination Phase 4
47 Contraceptives, Oral, Combined Phase 4
48 Contraceptives, Oral Phase 4
49 Estradiol 3-benzoate Phase 4
50 Contraceptive Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 89)
# Name Status NCT ID Phase Drugs
1 SDD for Eradicating CRKP Carriage Unknown status NCT01761487 Phase 4
2 Safety and Efficacy Study of High Dose Colistin Unknown status NCT02162966 Phase 4 High Dose Colistin;Standard Dose Colistin
3 Antibiotics for Klebsiella Liver Abscess Study Completed NCT01723150 Phase 4 Ciprofloxacin;Ceftriaxone;Trimethoprim/sulfamethoxazole;Ertapenem
4 Moxifloxacin Versus Ceftriaxone in the Treatment of Primary Pyogenic Liver Abscess Completed NCT00895089 Phase 4 Moxifloxacin (Avelox);ceftriaxone
5 Piperacillin/Tazobactam Versus Carbapenems in Non-bacteremic UTI Due to -ESBL-producing Enterobacteriaceae Recruiting NCT03891433 Phase 4 Meropenem;Ertapenem 1000 MG;Piperacillin, Tazobactam 4-0.5G Solution for Injection
6 Clinical and Immunological Efficiency of Bacterial Vaccines at Adult Patients With Bronchopulmonary Pathology Recruiting NCT02787863 Phase 4 Polioxidonium
7 Preventing Recurrent Urinary Tract Infections With α-D-mannose Recruiting NCT03497598 Phase 4 Mannose;Lactose
8 RCT Meropenem vs Piperacillin-Tazobactam for Definitive Treatment of BSI's Due to Ceftriaxone Non-susceptible Escherichia Coli and Klebsiella Spp. Terminated NCT02176122 Phase 4 Meropenem;Piperacillin-tazobactam combination product
9 Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") Terminated NCT00747461 Phase 4
10 Effectiveness of Two Protocols for Corporal Decolonization in Patients Colonized by Methicillin Resistant Staphylococcus Aureus (MRSA) Terminated NCT01400308 Phase 4 Mupirocin + Chlorhexidin
11 Efficacy and Safety of Colistin for Therapy of Infections Caused by ESBL Producing K.Pneumoniae or E.Coli Unknown status NCT00300560 Phase 3 Colistin
12 Chlorhexidine Gluconate Cleansing in Preventing Central Line Associated Bloodstream Infection and Acquisition of Multi-drug Resistant Organisms in Younger Patients With Cancer or Undergoing Donor Stem Cell Transplant Unknown status NCT01817075 Phase 3 Chlorhexidine Gluconate
13 Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn Unknown status NCT00136370 Phase 3 Chlorhexidine
14 Study Evaluating Tigecycline in Selected Serious Infections Due to Resistant Gram-Negative Organisms Completed NCT00079989 Phase 3 tigecycline
15 Broncho-Vaxom (OM 85 BV) in Children Suffering From Atopic Dermatitis Completed NCT03047954 Phase 3 Broncho-Vaxom;Placebo - Cap
16 A Study to Evaluate Efficacy of Tocilizumab Administered as Monotherapy or in Combination With Methotrexate and/or Other Disease Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis (RA) Participants Completed NCT01941940 Phase 3 Tocilizumab;DMARDs
17 Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and AP Completed NCT02166476 Phase 3 Meropenem-Vaborbactam;Piperacillin-Tazobactam;Levofloxacin;Saline
18 Efficacy Of Bacterial Lysate In Asthmatic Children Completed NCT02541331 Phase 3
19 Trial for the Treatment of Extensively Drug-Resistant Gram-negative Bacilli Recruiting NCT01597973 Phase 3 colistin and meropenem;colistin and placebo
20 Polymyxin B Monotherapy vs Combination Therapy in Critically Ill Patients With Multi-drug Resistant Pathogens Recruiting NCT03159078 Phase 3 Polymyxin B
21 Sitafloxacin and Ertapenem Treatment for Acute Urinary Tract Infection Caused by E. Coli or K. Pneumoniae in Post-kidney Transplantation Patients Active, not recruiting NCT02729116 Phase 2, Phase 3 Sitafloxacin;Ertapenem
22 A Safety and Tolerability Study of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pneumonia Terminated NCT01110421 Phase 3 Cefepime placebo;Cefepime;Doripenem;Doripenem placebo;Amoxicillin/clavulanate potassium
23 Probiotics for Eradication of Carbapenem Resistant Klebsiella Pneumonia Unknown status NCT00722410 Phase 1, Phase 2 Polyethylene glycol
24 Pilot Study of the Effectiveness of Probiotics and Lactitol for the Decolonization of OXA-48 (Carbapenemase) Producing Klebsiella Pneumoniae Among Rectal Carriers Unknown status NCT02307383 Phase 2 Lactitol;Lactobacillus
25 Effect of Improved Oral Hygiene to Prevent Pneumonia in Hospitalized Patients Completed NCT00123123 Phase 2 chlorhexidine gluconate oral rinse (0.12%);placebo
26 Evaluation of Cipro Inhale in Patients With Non-cystic Fibrosis Bronchiectasis Completed NCT00930982 Phase 2 Ciprofloxacin (Cipro, BAYQ3939);Placebo
27 Oral Bacterial Extract for the Prevention of Wheezing Lower Respiratory Tract Illness Recruiting NCT02148796 Phase 2 Broncho-Vaxom
28 The SCOUT Study: "Short Course Therapy for Urinary Tract Infections in Children" Recruiting NCT01595529 Phase 2 Cefixime;Cephalexin;Trimethoprim/Sulfamethoxazole
29 Pentaglobin in CRE and PA Neutropenic Infections Not yet recruiting NCT03494959 Phase 2 Pentaglobin
30 Dosing Study of Cranberry Capsules for the Prevention of Bacteriuria in Nursing Home Residents Completed NCT01033383 Phase 1
31 Single and Multiple Dose Evaluation of QBKPN SSI In Healthy Volunteers Withdrawn NCT02897999 Phase 1
32 A Randomized Trial Comparing Matt and Antimicrobial Cellomed Laminates Unknown status NCT01245829 Not Applicable
33 SATURN 04 Nosocomial Acquisition Study Unknown status NCT01208519
34 Microbiology and Clinical Outcome of Pneumonia Unknown status NCT00873522
35 Feasibility Studies to Inform Novel Proposals to Avert Community-Based Antimicrobial Resistance Spread Unknown status NCT02666274
36 Experimental Phage Therapy of Bacterial Infections Unknown status NCT00945087 Not Applicable
37 Stool Transplantation to Reduce Antibiotic Resistance Transmission Unknown status NCT02461199
38 Group B Streptococcus (GBS) Associated Stillbirths in a High Burden Setting Unknown status NCT02339077
39 Assessing the Effect of Contact Isolation on Nosocomial Colonization With ESBL-EC in German Hematology/Oncology Wards Unknown status NCT02456818
40 The Incidence of Extended-spectrum β-lactamase (ESBL) Klebsiella Pneumonia in Patient on Renal Replacement Therapy Completed NCT01612182
41 A Study Evaluating the Role of Oral Antibiotics in an Aim to Eradicate Carrier State of Carbapenem- Resistant Klebsiella Pneumonia (KPC). Completed NCT01266499 Not Applicable Colistin (Polymyxin E) 100mg x 4/d;both medications;will not receive PO treatment;PO Garamycin 80mg x 4/d
42 Double Carbapenem as Rescue Strategy for the Treatment of Carbapenemase-Producing Klebsiella Pneumoniae Infections Completed NCT03094494
43 Risk Factors for Quinolone Resistance Among ESBL Producing Klebsiella Species Completed NCT00518661
44 Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features Completed NCT01139112
45 Study Evaluating Antibiotic Use in Reducing Vancomycin-Resistant Enterococci and ESBL Producing Escherichia Coli and Klebsiella Pneumoniae in Intensive Care Completed NCT00167986 vancomycin-resistant enterococci and ESBL
46 Efficacy of Intestinal Decontamination in Patients Colonized by Carbapenem-resistant Klebsiella Pneumoniae and Colistin Completed NCT02604849 Neomycin;Streptomycin;Gentamicins
47 Selective Digestive Decontamination in Carriers of Carbapenem-resistant Klebsiella Pneumoniae Completed NCT00753558 Not Applicable Arm #1 :Oral solution and buccal gel of gentamicin and polymyxin E. Arm #2: Placebo.
48 Study Evaluating Piperacillin-Tazobactam on Certain Bacteria in Hematology and Oncology Units Completed NCT00167999 piperacillin-tazobactam
49 Colonization With Extended-Spectrum Beta-Lactamase (ESBL)-Producing Organisms Completed NCT01324726
50 Community - Associated Extended-spectrum Beta-lactamases (ESBL) Completed NCT00363220

Search NIH Clinical Center for Klebsiella Infection

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Klebsiella Infection

Anatomical Context for Klebsiella Infection

MalaCards organs/tissues related to Klebsiella Infection:

42
Colon, Liver, Kidney, Neutrophil, Thyroid, Lung, Brain

Publications for Klebsiella Infection

Articles related to Klebsiella Infection:

(show top 50) (show all 66)
# Title Authors Year
1
Colistin-Resistant Klebsiella Infections Among Pediatric Oncology and Hematopoietic Stem Cell Transplantation Patients in Eastern India. ( 29173228 )
2018
2
Newborn with rash due to Klebsiella infection. ( 28012933 )
2017
3
Incidence of Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Infections in the United States: A Systematic Literature Review. ( 28758612 )
2017
4
BamB and outer membrane biogenesis - The Achilles' heel for targeting Klebsiella infections? ( 27129024 )
2016
5
Intrapulmonary administration of leukotriene B(4) augments neutrophil accumulation and responses in the lung to Klebsiella infection in CXCL1 knockout mice. ( 22379035 )
2012
6
Evaluation of virulent multidrug resistant Klebsiella infection status in a tertiary care hospital in Eastern India. ( 23785917 )
2012
7
CXCL1 regulates pulmonary host defense to Klebsiella Infection via CXCL2, CXCL5, NF-kappaB, and MAPKs. ( 20937845 )
2010
8
Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. ( 19342674 )
2009
9
Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection. ( 19846873 )
2009
10
Decreased neutrophil response in a model of chronic intraperitoneal Klebsiella infection. ( 17635060 )
2007
11
A possible link between Crohn's disease and ankylosing spondylitis via Klebsiella infections. ( 16941202 )
2007
12
IL-10 in antilipopolysaccharide immunity against systemic Klebsiella infections. ( 17392590 )
2006
13
Proinflammatory cytokines in antilipopolysaccharide immunity against Klebsiella infections. ( 16030391 )
2005
14
STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection. ( 15356157 )
2004
15
CpG oligodeoxynucleotides stimulate protective innate immunity against pulmonary Klebsiella infection. ( 15470059 )
2004
16
O antigen seroepidemiology of Klebsiella clinical isolates and implications for immunoprophylaxis of Klebsiella infections. ( 15040933 )
2004
17
Klebsiella infection in patients with thalassemia. ( 12594637 )
2003
18
Nosocomial Klebsiella infection in neonates in a tertiary care hospital: protein profile by SDS-page and klebocin typing as epidemiological markers. ( 17642987 )
2003
19
Klebsiella infections in the immunocompromised host. ( 10897425 )
2000
20
Exogenous cytokine modulation or neutralization of interleukin-10 enhance survival in lipopolysaccharide-hyporesponsive C3H/HeJ mice with Klebsiella infection. ( 10469238 )
1999
21
Hyperammonaemia due to Klebsiella infection in a neuropathic bladder. ( 9811390 )
1998
22
Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection. ( 9125558 )
1997
23
Clinical, bacteriological, and serological aspects of Klebsiella infections and their spondylarthropathic sequelae. ( 9220153 )
1997
24
O-antigen seroepidemiology of Klebsiella clinical isolates and implications for immunoprophylaxis of Klebsiella infections. ( 9302204 )
1997
25
Nosocomial outbreak of Klebsiella infection resistant to late-generation cephalosporins. ( 8135915 )
1993
26
Severe Klebsiella infection as a cause of mortality in neonates in Harare, Zimbabwe: evidence from postmortem blood cultures. ( 8284121 )
1993
27
Epidemiological analysis of Klebsiella infections at a neonate department. ( 1512448 )
1992
28
The relationship between Klebsiella infection and ankylosing spondylitis. ( 2670258 )
1989
29
Serum immunoglobulin levels in patients with active pulmonary tuberculosis and patients with Klebsiella infection. ( 3623633 )
1987
30
An outbreak of serious Klebsiella infections related to food blenders. ( 2883228 )
1987
31
The sera of patients with Klebsiella infections contain a common anti-DNA idiotype (16/6) Id and anti-polynucleotide activity. ( 3301096 )
1987
32
Klebsiella infection in a neonatal intensive care unit: role of bacteriological surveillance. ( 6085092 )
1984
33
Klebsiella infection in a neonatal intensive care unit. ( 6397862 )
1984
34
Experimental model of Klebsiella infection in mice for studies on mechanisms of local immunity of the respiratory tract. ( 6357970 )
1983
35
Klebsiella-induced LIF response in Klebsiella infection and ankylosing spondylitis. ( 6360292 )
1983
36
Progress in immunization against Klebsiella infections. ( 6365535 )
1983
37
Amelioration by muramyl dipeptide of the effect of induced hyperferremia upon Klebsiella infection in mice. ( 6754611 )
1982
38
Fate of two 14C labelled muramyl peptides: Ac-Mur-L-Ala-gamma-D-Glu-meso-A2pm and Ac-Mur-L-Ala-gamma-D-Glu-meso-A2pm-D-Ala-D-Ala in mice. Evaluation of their ability to increase non specific resistance to Klebsiella infection. ( 7049971 )
1982
39
Veterinary nosocomial (hospital-acquired) Klebsiella infections. ( 7341571 )
1981
40
Nosocomial klebsiella infection in a neonatal unit: identification of risk factors for gastrointestinal colonization. ( 7005139 )
1980
41
Epidemiological study of klebsiella infection in the special care baby unit of a London hospital. ( 7400339 )
1980
42
An investigation into the incidence and sources of klebsiella infections in hospital patients. ( 376698 )
1979
43
Klebsiella infections in mares. ( 516337 )
1979
44
The use of a fluorescence typing method in an epidemiological study of Klebsiella infection in a London hospital. ( 340582 )
1978
45
Enhancement of the neonate's nonspecific immunity to Klebsiella infection by muramyl dipeptide, a synthetic immunoadjuvant. ( 356054 )
1978
46
Microbial iron-chelators and their action on Klebsiella infections in the skin of guinea-pigs. ( 350255 )
1978
47
Gentamicin-resistant Klebsiella infections in a neonatal intensive care unit. ( 645665 )
1978
48
Comparison of bacteriophage typing, serotyping, and biotyping as aids in epidemiological surveillance of Klebsiella infections. ( 744797 )
1978
49
Bladder response to klebsiella infection: a scanning electron microscopy study. ( 338544 )
1977
50
Nosocomial Klebsiella infections in an intensive care nursery. ( 320669 )
1977

Variations for Klebsiella Infection

Expression for Klebsiella Infection

Search GEO for disease gene expression data for Klebsiella Infection.

Pathways for Klebsiella Infection

GO Terms for Klebsiella Infection

Sources for Klebsiella Infection

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