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MCID: KLB003
MIFTS: 49

Klebsiella Pneumonia

Categories: Infectious diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Klebsiella Pneumonia

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MalaCards integrated aliases for Klebsiella Pneumonia:

Name: Klebsiella Pneumonia 12 54 15
Pneumonia Due to Klebsiella Pneumoniae 12 32
Klebsiella Infections 44 17

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:13272
ICD9CM 34 482.0
MeSH 44 D007710
ICD10 32 B96.1 J15.0
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Summaries for Klebsiella Pneumonia

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Disease Ontology : 12 A bacterial pneumonia involving Klebsiella pneumoniae infection. Patients with Klebsiella pneumonia tend to cough up a characteristic sputum that is said to resemble red-currant jelly. Klebsiella pneumonia tends to affect people with underlying diseases, such as alcoholism, diabetes and chronic lung disease. The symptoms include high fever, rigors and pleuritic pain, and hemoptysis.

MalaCards based summary : Klebsiella Pneumonia, also known as pneumonia due to klebsiella pneumoniae, is related to urinary tract infection and lung abscess. An important gene associated with Klebsiella Pneumonia is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Tazobactam and Piperacillin have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and heart, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 73 Klebsiella pneumoniae is a Gram-negative, non-motile, encapsulated, lactose-fermenting, facultative... more...

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Related Diseases for Klebsiella Pneumonia

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Diseases related to Klebsiella Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 896)
# Related Disease Score Top Affiliating Genes
1 urinary tract infection 30.2 TLR4 CRP
2 lung abscess 30.2 TNF IL6 CRP CD4 ALB
3 thrombophlebitis 30.1 PLAT CRP ALB
4 pneumonia 30.0 TNF TLR4 TLR2 IL6 IL1B IL17A
5 epidural abscess 29.9 CRP CD4 ALB
6 fasciitis 29.9 VIM TNF IL6 CXCL8
7 polyneuropathy 29.8 TNF IL6 CRP ALB
8 thrombocytosis 29.8 IL6 IL1B CRP ALB
9 pancytopenia 29.8 IL6 H2AC18 CRP CD4
10 spondyloarthropathy 1 29.8 TNF TLR4 IL6 IL17A ICOSLG CRP
11 pleural empyema 29.7 IL6 CRP CD4 ALB
12 conjunctivitis 29.7 TNF TLR4 IL6 IL10 CXCL8
13 churg-strauss syndrome 29.7 TNF IL1B IL17A IL10 CXCL8
14 myocarditis 29.6 TNF TLR4 IL6 IL1B IL17A IL10
15 acute myocarditis 29.6 TNF IL10 H2AC18 CRP CD4
16 endophthalmitis 29.6 TNF TLR2 IL6 IL1B CXCL8 CRP
17 bronchiectasis 29.5 TNF TLR2 IL1B CXCL8 CRP
18 spondylitis 29.5 TNF IL6 IL1B IL17A IL10 ICOSLG
19 hypopyon 29.5 TNF IL6 IL1B IL17A IL10 CRP
20 prostatitis 29.5 TNF IL6 IL1B IL17A IL10 CXCL8
21 cellulitis 29.4 TNF IL6 CRP CD4 CCR6 ALB
22 necrotizing fasciitis 29.3 IL6 IL1B H2AC18 CXCL8 CRP ALB
23 granulomatosis with polyangiitis 29.3 TNF TLR4 TLR2 ICOSLG CRP CD4
24 toxic shock syndrome 29.1 TNF TLR4 TLR2 IL6 IL1B IL10
25 diarrhea 29.1 TNF TLR4 IL6 IL1B IL10 CXCL8
26 chlamydia 29.0 TNF TLR4 TLR2 IL6 IL1B IL17A
27 meningitis 29.0 TNF TLR4 TLR2 IL6 IL1B IL17A
28 allergic disease 28.9 TNF TLR4 TLR2 IL6 IL1B IL10
29 pyelonephritis 28.9 TNF TLR4 IL6 IL1B IL10 CXCL8
30 respiratory failure 28.6 TNF TLR4 IL6 IL1B IL10 H2AC18
31 peritonitis 28.6 TNF TLR4 TLR2 IL6 IL1B IL10
32 alcoholic hepatitis 28.6 TNF TLR4 TLR2 IL6 IL1B IL10
33 bacterial meningitis 28.4 TNF TLR4 TLR2 IL6 IL1B IL17A
34 dysentery 28.4 TNF IL6 IL1B IL10 H2AC18 CXCL8
35 bacterial infectious disease 28.4 TNF TLR4 TLR2 IL6 IL1B IL17A
36 bacterial pneumonia 28.4 TNF TLR4 TLR2 IL6 IL1B IL17A
37 bronchopneumonia 28.4 TNF TLR4 IL6 IL1B IL17A IL10
38 thrombocytopenia 28.3 TNF TLR4 TLR2 PLAT IL6 IL1B
39 acute cystitis 27.9 VIM UBAC1 TNF TLR4 OXA1L IL6
40 crohn's disease 27.8 TNF TLR4 TLR2 IL6 IL1B IL17A
41 external pathological resorption 10.4 TNF IL6
42 scorpion envenomation 10.4 TNF IL6
43 punctate inner choroidopathy 10.4 TNF IL10
44 tropical endomyocardial fibrosis 10.3 TNF IL10
45 chromium allergic contact dermatitis 10.3 IL17A IL10
46 autoimmune polyendocrine syndrome type 1 10.3 IL17A H2AC18 CCR6
47 periodontitis, chronic 10.3 IL6 IL1B
48 staphylococcal toxic shock syndrome 10.3 TNF IL1B
49 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 TNF IL6
50 cardiogenic shock 10.3 TNF PLAT IL6

Graphical network of the top 20 diseases related to Klebsiella Pneumonia:



Diseases related to Klebsiella Pneumonia
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Symptoms & Phenotypes for Klebsiella Pneumonia

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MGI Mouse Phenotypes related to Klebsiella Pneumonia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.24 ALB CCR6 CD248 CD4 CRP IL10
2 cardiovascular system MP:0005385 10.2 ALB CRP IL10 IL1B IL6 PLAT
3 hematopoietic system MP:0005397 10.18 CCR6 CD248 CD4 IL10 IL17A IL1B
4 immune system MP:0005387 10.17 ALB CCR6 CD248 CD4 CRP IL10
5 digestive/alimentary MP:0005381 10.09 ALB CD4 IL10 IL17A IL6 PLAT
6 integument MP:0010771 9.96 CD248 CD4 IL10 IL17A IL1B IL6
7 muscle MP:0005369 9.76 ALB IL10 IL6 PLAT TLR2 TLR4
8 neoplasm MP:0002006 9.56 ALB CD248 IL10 IL1B IL6 TLR2
9 respiratory system MP:0005388 9.23 IL10 IL17A IL6 PLAT TLR2 TLR4
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Drugs & Therapeutics for Klebsiella Pneumonia

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Drugs for Klebsiella Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tazobactam Approved Phase 4 89786-04-9 123630
2
Piperacillin Approved Phase 4 66258-76-2 43672
3
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
4
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
5
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
6
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
7
Sulfamethoxazole Approved Phase 4 723-46-6 5329
8
Meropenem Approved, Investigational Phase 4 96036-03-2, 119478-56-7 64778 441130
9
Colistin Approved Phase 4 1066-17-7, 1264-72-8 5311054
10
Polymyxin B Approved, Vet_approved Phase 4 1404-26-8
11
Tigecycline Approved Phase 4 220620-09-7 5282044
12
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
13 Piperacillin, Tazobactam Drug Combination Phase 4
14 beta-Lactamase Inhibitors Phase 4
15 Folic Acid Antagonists Phase 4
16 Vitamin B9 Phase 4
17 Antiparasitic Agents Phase 4
18 Vitamin B Complex Phase 4
19 Liver Extracts Phase 4
20 Folate Phase 4
21 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
22 Antimalarials Phase 4
23 Antiprotozoal Agents Phase 4
24 Cytochrome P-450 Enzyme Inhibitors Phase 4
25 Anti-Bacterial Agents Phase 4
26 Anti-Infective Agents Phase 4
27 Polymyxins Phase 4
28
Ertapenem Approved, Investigational Phase 2, Phase 3 153832-46-3 150610
29
Sitafloxacin Experimental, Investigational Phase 2, Phase 3 163253-35-8
30 Immunoglobulins Phase 3
31 Immunoglobulin E Phase 3
32 Immunoglobulins, Intravenous Phase 3
33 Antibodies Phase 3
34 Antibiotics, Antitubercular Phase 2, Phase 3
35 Immunologic Factors Phase 3
36 Broncho-Vaxom Phase 3
37
Lactitol Approved, Investigational Phase 2 585-86-4 157355
38 Acidophilus Phase 2
39 Cathartics Phase 2
40 Gastrointestinal Agents Phase 2
41 Laxatives Phase 2
42
Fosfomycin Approved Early Phase 1 23155-02-4 446987
43
Neomycin Approved, Vet_approved 1404-04-2 8378
44
Streptomycin Approved, Vet_approved 57-92-1 19649
45
Vancomycin Approved 1404-90-6 441141 14969
46
Mineral oil Approved, Vet_approved 8042-47-5
47
Imipenem Approved 64221-86-9, 74431-23-5 104838
48 Gentamicins
49 Pharmaceutical Solutions
50 Carboxymethylcellulose Sodium

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 SELECTIVE DIGESTIVE DECONTAMINATION USING ORAL GENTAMICIN AND ORAL POLYMYXIN E FOR ERADICATION OF CARBAPENEM-RESISTANT KLEBSIELLA PNEUMONIAE CARRIAGE IN HOSPITALIZED PATIENTS Unknown status NCT01761487 Phase 4
2 Piperacillin/Tazobactam Versus Carbapenems in Non-bacteremic Urinary Tract Infections Due to Extended-spectrum β-lactamase (ESBL)-Producing Escherichia Coli or Klebsiella Pneumoniae - (CAPITIS Study) Unknown status NCT03891433 Phase 4 Meropenem;Ertapenem 1000 MG;Piperacillin, Tazobactam 4-0.5G Solution for Injection
3 A Multi-centre Randomised Open-label Active Comparator-controlled Non-inferiority Trial Comparing Oral to Intravenous Antibiotics in the Early Management of Klebsiella Pneumoniae Liver Abscess Completed NCT01723150 Phase 4 Ciprofloxacin;Ceftriaxone;Trimethoprim/sulfamethoxazole;Ertapenem
4 Comparative Clinical Study Between Colistin-Tigecycline Combined Therapy Versus Colistin-Meropenem Combined Therapy in Treatment of Blood Stream Infections With Multidrug-Resistant Klebsiella Pneumoniae Recruiting NCT04489459 Phase 4 Colistin;Meropenem;Tigecycline
5 Efficacy and Safety of Colistin for Therapy of Infections Caused by Extended Spectrum Beta-Lactamase(ESBL) Producing Klebsiella Pneumoniae or Escherichia Coli Unknown status NCT00300560 Phase 3 Colistin
6 The Effect Of Polivalent Mechanical Bacterial Lysate On The Clinical Course Of Grass Pollen-Induced Allergic Rhinitis In Children Completed NCT04270552 Phase 3 Ismigen;Placebo
7 The Effect of Polyvalent Mechanical Bacterial Lysate on the Reduction of Nasal Staphylococcus Aureus Carriage in Children With Pollen Allergic Rhinitis Completed NCT04637425 Phase 3 Ismigen;Placebo
8 Multicentre, Randomised, Double Blind, Placebo-controlled Study of the Efficacy and Safety of Broncho-Vaxom (OM 85 BV) in Children Suffering From Atopic Dermatitis Completed NCT03047954 Phase 3 Broncho-Vaxom;Placebo - Cap
9 A Phase 3, Open-label, Noncomparative Study of Tigecycline for the Treatment of Subjects With Selected Serious Infections Due to Resistant Gram-negative Organisms Such as Enterobacter Species, Acinetobacter Baumannii, and Klebsiella Pneumoniae Completed NCT00079989 Phase 3 tigecycline
10 Sitafloxacin and Ertapenem Treatment for Acute Urinary Tract Infection Caused by E. Coli or K. Pneumoniae in Post-kidney Transplantation Patients Recruiting NCT02729116 Phase 2, Phase 3 Sitafloxacin;Ertapenem
11 The Effect of Immunostimulation With Polyvalent Mechanical Bacterial Lysate on Changes in the Concentration of iNKT Cells in Children With Allergic Rhinitis. Enrolling by invitation NCT04802616 Phase 3 Ismigen;Placebo
12 Safety and Efficacy Study of Eradication of Carbapenem Resistant Klebsiella Pneumonia From the Gastrointestinal Tract by Probiotics. Unknown status NCT00722410 Phase 1, Phase 2 Polyethylene glycol
13 Pilot Study of the Effectiveness of Probiotics and Lactitol for the Intestinal Decolonization of People Carriers of Klebsiella Pneumoniae Producers of Carbapenemase OXA-48-type: DesProbiOXA Study Unknown status NCT02307383 Phase 2 Lactitol;Lactobacillus
14 Randomized, Superiority, Double Blind Controlled With Placebo, Clinical Trial, to Demonstrate the Effectiveness of Fecal Microbiota Transplantation for Selective Intestinal Decolonization of Patients Colonized by Klebsiella Pneumoniae Carbapenemase (KPC)-Producing Not yet recruiting NCT04760665 Phase 2
15 A Placebo-Controlled, Blinded, Dose-Escalation, Study to Assess the Safety and Pharmacodynamics of Single and Multiple Doses of QBKPN (Inactivated Klebsiella Pneumoniae) Site Specific Immunomodulator (SSI), Administered Subcutaneously to Healthy Male and Female Volunteers Withdrawn NCT02897999 Phase 1
16 Klebsiella Pneumoniae Infection in China: Epidemiology, Molecular Characteristics, Treatment, and Outcome Unknown status NCT03598543
17 Epidemiological Characteristics and Treatment Protocol for Carbapenem-Resistant Klebsiella Pneumoniae in China Unknown status NCT03245632
18 How to Optimize the Combined Antibiotic Therapy for Carbapenem Resistant Klebsiella Pneumoniae Unknown status NCT03950544 Early Phase 1 Fosfomycin;Tigecycline;Polymyxin B
19 Turkish Prospective Cohort Study on Carbapenem Resistant Klebsiella Pneumonia Bacteremia: a National Multicenter Observational Study Completed NCT03597841 Combination therapy
20 Efficacy of Intestinal Decontamination in Patients Colonized by Carbapenem-resistant Klebsiella Pneumoniae and Colistin Completed NCT02604849 Neomycin;Streptomycin;Gentamicins
21 A Randomized Open Label Study Evaluating the Role of Oral Antibiotics in an Aim to Eradicate Carrier State of Carbapenem- Resistant Klebsiella Pneumonia (KPC). Completed NCT01266499 Colistin (Polymyxin E) 100mg x 4/d;both medications;will not receive PO treatment;PO Garamycin 80mg x 4/d
22 Sites of Colonization in Hospitalized Patients With Infections Caused by Extended-Spectrum Beta-Lactamase Producing Escherichia Coli and Klebsiella Pneumoniae Completed NCT01324726
23 Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features Completed NCT01139112
24 Effects of Piperacillin-Tazobactam Use on the Prevalence Rate of Extended-Spectrum Beta-Lactamase (ESBL) Producing Escherichia Coli and Klebsiella Pneumoniae in Hematology and Oncology Units. Completed NCT00167999 piperacillin-tazobactam
25 Antibiotic Intervention Trial in a Medical Intensive Care Unit to Reduce the Acquisition of Vancomycin-Resistant Enterococci and ESBL Producing Escherichia Coli and Klebsiella Pneumoniae. Completed NCT00167986 vancomycin-resistant enterococci and ESBL
26 Double Carbapenem as Rescue Strategy for the Treatment of Severe Carbapenemase-Producing Klebsiella Pneumoniae Infections: A Two-Center Matched Case-Control Study Completed NCT03094494
27 Antimicrobial Resistance Rate In Escherichia Coli And Klebsiella Pneumonia : A Retrospective Study Completed NCT04196387
28 The Incidence of Extended-spectrum β-lactamase (ESBL) Klebsiella Pneumonia in Patient on Renal Replacement Therapy Completed NCT01612182
29 A Randomized,Double-Blind,Placebo-Controled Trial of Selective Digestive Decontamination Using Oral Gentamicin and Oral Polymyxin E for Eradication of Carbapenem-Resistant Klebsiella Pneumoniae Carriage Completed NCT00753558 Arm #1 :Oral solution and buccal gel of gentamicin and polymyxin E. Arm #2: Placebo.
30 Analysis of the Clinical Characteristics for the Critical Ill Patients With Klebsiella Pneumoniae Infection: A Multi-center Research in the Intensive Care Units Completed NCT04404582
31 Community-Onset Bacteremia Due to Extended-Spectrum β-Lactamase (ESBL)Producing Escherichia Coli or Klebsiella Pneumoniae in China: Prevalence, Risk Factors and Prognosis Completed NCT01961206
32 Risk Factors for Quinolone Resistance Among Extended-Spectrum Beta-Lactamase-Producing Klebsiella Species Completed NCT00518661
33 Community - Associated Extended-spectrum Beta-lactamases (ESBL) Completed NCT00363220
34 WGS-guided Tracking and Infection Control Measures of Carbapenem-resistant Klebsiella Pneumoniae Recruiting NCT04413305
35 Genetic Characterization of Plasmids Carrying Carbapenemases and Quinolone Resistance Determinants in Klebsiella Pneumoniae Isolates in Assiut University Hospitals Recruiting NCT03767283
36 Understanding and Modelling Reservoirs, Vehicles and Transmission of ESBL-producing Enterobacteriaceae in the Community and Long Term Care Facilities Enrolling by invitation NCT03477084
37 Comparison of Clinical Outcomes in Bloodstream Infections With Carbapenem Hetero-resistant vs Carbapenem Resistant Klebsiella Pneumoniae (COMBAT) Not yet recruiting NCT04229498 Monotherapy and combination therapy (all antibiotics that are given by attending pysicians and can be active against Klebsiella pneumoniae will be evaluated)
38 Analysis on the Infection Risk, Prognosis, and Drug Sensitivity of Klebsiella Pneumoniae. Not yet recruiting NCT04337840
39 Oral and Tracheal Cultures in Pediatric ICU Patients Compared to Healthy Children Not yet recruiting NCT03418272

Search NIH Clinical Center for Klebsiella Pneumonia

Cochrane evidence based reviews: klebsiella infections

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Genetic Tests for Klebsiella Pneumonia

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Anatomical Context for Klebsiella Pneumonia

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MalaCards organs/tissues related to Klebsiella Pneumonia:

40
Bone, Liver, Heart, Skin, Lung, Kidney, Eye
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Publications for Klebsiella Pneumonia

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Articles related to Klebsiella Pneumonia:

(show top 50) (show all 1218)
# Title Authors PMID Year
1
Nosocomial bloodstream infections in a pediatric intensive care unit: 3-year survey. 61 54
17534230 2007
2
Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases. 61 54
15206050 2004
3
Biocidal (bacterial and cancer cells) activities of chitosan/CuO nanomaterial, synthesized via a green process. 61
33674015 2021
4
Genome sequencing and comparative genome analysis of 6 hypervirulent Klebsiella pneumoniae strains isolated in China. 61
33811489 2021
5
Seaweed-associated heterotrophic bacteria: new paradigm of prospective anti-infective and anticancer agents. 61
33140140 2021
6
Production of composted recycled manure solids from a Canadian dairy farm: Impact on microbial air quality in experimental conditions. 61
33030410 2021
7
Establishment and evaluation of an indirect ELISA for detection of antibodies to goat Klebsiella pneumonia. 61
33663505 2021
8
Is Carbapenem-resistant Klebsiella pneumoniae Infection in Pediatric Bone Marrow Transplantation Recipients Inevitably Fatal? 61
33710116 2021
9
Antibacterial, Antifungal, Antioxidant, and Docking Studies of Potential Dinaphthodiospyrols from Diospyros lotus Linn Roots. 61
33681626 2021
10
Carbapenem-Resistant Enterobacteriaceae-Implications for Treating Acute Leukemias, a Subgroup of Hematological Malignancies. 61
33808761 2021
11
Elucidating the anti-biofilm and anti-quorum sensing potential of selenocystine against respiratory tract infections causing bacteria: in vitro and in silico studies. 61
33735944 2021
12
The endolysin of the Acinetobacter baumannii phage vB_AbaP_D2 shows broad antibacterial activity. 61
32519416 2021
13
Characteristics of Asymptomatic Bacteriuria in Diabetes Mellitus Patients: A Retrospective Observational Study. 61
33791179 2021
14
Bacteremia due to healthcare-associated urinary tract infections in children. 61
33446433 2021
15
Investigation of biological activity of soil fungal extracts and LC/MS-QTOF based metabolite profiling. 61
33637771 2021
16
Alkaloids from the root of Indonesian Annona muricata L. 61
31282747 2021
17
Case Report: A 64-Year-Old Man with 10-Year History of Eosinophilic Granulomatosis with Polyangiitis with Bronchiectasis and Severe Klebsiella pneumonia. 61
33582702 2021
18
Addressable nanoantennas with cleared hotspots for single-molecule detection on a portable smartphone microscope. 61
33574261 2021
19
Green synthesis, in vivo and in vitro pharmacological studies of Tamarindus indica based gold nanoparticles. 61
33582887 2021
20
Renal Transplant in Pediatric Patients With Congenital Abnormalities of the Lower Urinary Tract. 61
33605195 2021
21
Nanocellulose from Cotton Waste and Its Glycidyl Methacrylate Grafting and Allylation: Synthesis, Characterization and Adsorption Properties. 61
33668489 2021
22
Antimicrobial effects of nitric oxide in murine models of Klebsiella pneumonia. 61
33352464 2021
23
Antibacterial evaluation and molecular docking studies of pyrazole-thiosemicarbazones and their pyrazole-thiazolidinone conjugates. 61
32086698 2021
24
Distribution and resistance of pathogens in infected patients within 1 year after heart transplantation. 61
33212254 2021
25
A murine model to study the gut bacteria parameters during complex antibiotics like cefotaxime and ceftriaxone treatment. 61
33777338 2021
26
Short-chain cyanoacrylates and long-chain cyanoacrylates (Dermabond) have different antimicrobial effects. 61
33791434 2021
27
Graphitic carbon nitride: a sustainable photocatalyst for organic pollutant degradation and antibacterial applications. 61
32519096 2021
28
Gram-Negative Bacteria Isolates and Their Antibiotic-Resistance Patterns in Patients with Wound Infection in Ethiopia: A Systematic Review and Meta-Analysis. 61
33542636 2021
29
Probiotic Pediococcus acidilactici strain from tomato pickle displays anti-cancer activity and alleviates gut inflammation in-vitro. 61
33442521 2021
30
Synthesis, biological activity and POM/DFT/docking analyses of annulated pyrano[2,3-d]pyrimidine derivatives: Identification of antibacterial and antitumor pharmacophore sites. 61
33279245 2021
31
Pharmacological importance of TG12 from tachykinin and its toxicological behavior against multidrug-resistant bacteria Klebsiella pneumonia. 61
33465517 2021
32
Economic burden of antibiotic resistance in China: a national level estimate for inpatients. 61
33407856 2021
33
First determination of some phenolic compounds and antimicrobial activities of Geranium ibericum subsp. jubatum: A plant endemic to Turkey. 61
33679153 2021
34
Self-crosslinked chitosan/dialdehyde xanthan gum blended hypromellose hydrogel for the controlled delivery of ampicillin, minocycline and rifampicin. 61
33212108 2021
35
Significant higher airborne antibiotic resistance genes and the associated inhalation risk in the indoor than the outdoor. 61
33120141 2021
36
Occurrence and Phenotypic Characterization of Multidrug-Resistant Bacterial Pathogens Isolated from Patients in a Public Hospital in Mogadishu, Somalia. 61
33688217 2021
37
[Analysis of prognostic risk factors of bloodstream infection in intensive care unit patients]. 61
33541494 2020
38
Therapeutic sildenafil inhibits pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats. 61
31967915 2020
39
Efficacy and safety of interferon on neonates with respiratory syncytial virus pneumonia. 61
33193835 2020
40
[Specific immunization for the prevention of recurrent nephrolithiasis after percutaneous nephrolithotomy]. 61
33377684 2020
41
Protective multi-epitope candidate vaccine for urinary tract infection. 61
33304840 2020
42
The type I-E CRISPR-Cas system influences the acquisition of blaKPC-IncF plasmid in Klebsiella pneumonia. 61
32393110 2020
43
Stewardship actions for device associated infections: An intervention study in the emergency intensive care unit. 61
33148497 2020
44
Antimicrobial and antinematicidal metabolites from Streptomyces cuspidosporus strain SA4 against selected pathogenic bacteria, fungi and nematode. 61
33304126 2020
45
Cell-free supernatant of Streptococcus salivarius M18 impairs the pathogenic properties of Pseudomonas aeruginosa and Klebsiella pneumonia. 61
32747998 2020
46
Lawsonia inermis L. leaves aqueous extract as a natural antioxidant and antibacterial product. 61
30721090 2020
47
Carbapenem resistant organisms: A 9-year surveillance and trends at Saint George University Medical Center. 61
30956158 2020
48
N-(Hydroxyalkyl) Derivatives of tris(1H-indol-3-yl)methylium Salts as Promising Antibacterial Agents: Synthesis and Biological Evaluation. 61
33339219 2020
49
6-Nitro-1-benzylquinolones exhibiting specific antitubercular activity. 61
32558257 2020
50
Green synthesis of Ag and Pd nanoparticles for water pollutants treatment. 61
33339789 2020
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Variations for Klebsiella Pneumonia

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Expression for Klebsiella Pneumonia

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Search GEO for disease gene expression data for Klebsiella Pneumonia.
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Pathways for Klebsiella Pneumonia

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Pathways related to Klebsiella Pneumonia according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.08 VIM UBAC1 TNF TLR4 TLR2 IL6
2
ERK Signaling 63
Show member pathways
 13.86 VIM TNF IL6 IL1B IL17A IL10
3
PEDF Induced Signaling 63
Show member pathways
 13.73 TNF TLR4 IL6 IL1B IL17A IL10
4
Akt Signaling 63
Show member pathways
 13.48 TNF TLR4 TLR2 IL6 IL1B IL17A
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.43 VIM TNF IL6 IL1B IL17A IL10
6
PAK Pathway 63
Show member pathways
 13.37 TNF IL6 IL1B IL17A IL10 CXCL8
7
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.26 TNF TLR4 TLR2 IL6 IL1B IL10
8
Human cytomegalovirus infection 36
Show member pathways
 13.03 TNF TLR4 TLR2 IL6 IL1B CXCL8
9
Allograft rejection 36 1
Show member pathways
 12.92 VIM TNF IL6 IL1B IL17A IL10
10
Measles 36
Show member pathways
 12.9 VIM TNF TLR4 TLR2 IL6 IL1B
11
Salmonella infection (KEGG) 36
Show member pathways
 12.82 TNF TLR4 TLR2 IL6 IL1B CXCL8
12
NF-KappaB Family Pathway 63
Show member pathways
 12.75 TNF TLR4 TLR2 IL6 IL1B
13
Th17 cell differentiation 36
Show member pathways
 12.7 TNF TLR4 TLR2 IL6 IL1B IL17A
14
Immune response IL-23 signaling pathway 23
Show member pathways
 12.68 TNF IL6 IL1B IL17A IL10 CD4
15
NF-kappaB Signaling 4
12.63 TNF TLR2 IL1B IL17A IL10
16
T cell receptor signaling pathway 36
Show member pathways
 12.56 VIM TNF TLR4 TLR2 IL6 IL1B
17
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.52 TNF TLR4 TLR2 IL6 IL1B CXCL8
18
Selenium Micronutrient Network 1
Show member pathways
 12.43 TNF PLAT IL6 IL1B CRP ALB
19
IL-17 Family Signaling Pathways 64
Show member pathways
 12.43 TNF TLR2 IL6 IL1B IL17A CXCL8
20
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.42 TNF IL6 IL10 CXCL8 CCR6
21
Toll Comparative Pathway 63
Show member pathways
 12.4 TNF TLR4 IL6 IL1B CXCL8
22
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.36 TNF TLR4 TLR2 IL6 CXCL8
23
Toxoplasmosis 36
Show member pathways
 12.36 TNF TLR4 TLR2 IL1B IL10
24
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.36 TNF IL6 IL1B IL17A IL10 CXCL8
25
Tuberculosis 36
12.34 TNF TLR4 TLR2 IL6 IL1B IL10
26
NOD-like receptor signaling pathway 36
12.33 TNF TLR4 IL6 IL1B CXCL8
27
IL-1 Family Signaling Pathways 64
Show member pathways
 12.32 TNF TLR2 IL6 IL1B CXCL8
28
Bacterial infections in CF airways 23
Show member pathways
 12.29 TNF TLR4 TLR2 IL6 IL1B CXCL8
29
C-type lectin receptor signaling pathway 36
Show member pathways
 12.27 TNF IL6 IL1B IL10
30
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.27 TNF IL6 IL1B IL10 CXCL8
31
Necroptosis 36
Show member pathways
 12.26 TNF TLR4 IL1B H2AC18
32
Colorectal Cancer Metastasis 63
12.24 TNF TLR4 TLR2 IL6
33
Yersinia infection 36
12.14 TNF TLR4 IL6 IL1B IL10 CXCL8
34
Spinal Cord Injury 1
12.12 VIM TNF TLR4 IL6 IL1B CXCL8
35
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.08 TNF IL6 IL10 CD4
36
Senescence and Autophagy in Cancer 1
12.03 PLAT IL6 IL1B CXCL8
37
NF-kappa B signaling pathway 36
12.02 TNF TLR4 IL1B CXCL8
38
Interleukin-4 and 13 signaling 65
12.01 VIM TNF IL6 IL1B IL17A IL10
39
AGE-RAGE signaling pathway in diabetic complications 36
12 TNF IL6 IL1B CXCL8
40
Hematopoietic cell lineage 36
11.99 TNF IL6 IL1B CD4
41
Th17 Differentiation Pathway 64
Show member pathways
 11.97 TLR4 TLR2 IL6 IL1B IL17A CD4
42
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.96 TLR4 IL6 IL17A CXCL8
43
Innate Lymphoid Cell Differentiation Pathways 64
11.89 TNF IL1B IL17A IL10 CD4 CCR6
44
Dendritic Cells Developmental Lineage Pathway 64
11.87 TNF IL6 IL1B IL10 CD4
45
Amoebiasis 36
11.87 TNF TLR4 TLR2 IL6 IL1B IL10
46
Pertussis 36
11.84 TNF TLR4 IL6 IL1B IL10 CXCL8
47
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.77 TNF IL6 IL1B CXCL8
48
Rheumatoid arthritis 36
11.77 TNF TLR4 TLR2 IL6 IL1B IL17A
49
Lung fibrosis 1
11.76 TNF IL6 IL1B CXCL8
50
Legionellosis 36
11.67 TNF TLR4 TLR2 IL6 IL1B CXCL8
Sources

GO Terms for Klebsiella Pneumonia

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Cellular components related to Klebsiella Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 TNF PLAT IL6 IL1B IL17A IL10
2 cell surface GO:0009986 9.73 TNF TLR4 TLR2 PLAT CD4 CCR6
3 extracellular space GO:0005615 9.65 TNF PLAT IL6 IL1B IL17A IL10
4 external side of plasma membrane GO:0009897 9.17 TNF TLR4 IL17A ICOSLG CD4 CD248

Biological processes related to Klebsiella Pneumonia according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.32 TLR4 TLR2 IL6 IL1B IL10 ICOSLG
2 negative regulation of cell proliferation GO:0008285 10.09 TLR2 IL6 IL1B IL10 CXCL8
3 positive regulation of gene expression GO:0010628 10.01 VIM TNF TLR4 TLR2 IL6 IL1B
4 response to lipopolysaccharide GO:0032496 9.97 TLR4 TLR2 IL1B IL10
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TNF TLR4 TLR2 IL6 IL1B
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.93 TNF IL6 IL1B IL10
7 positive regulation of inflammatory response GO:0050729 9.91 TNF TLR4 TLR2 IL1B
8 positive regulation of tumor necrosis factor production GO:0032760 9.91 TLR4 TLR2 IL6 IL17A
9 defense response to Gram-negative bacterium GO:0050829 9.9 TLR4 IL6 IL17A CD4
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 TNF TLR4 TLR2 IL1B
11 defense response to Gram-positive bacterium GO:0050830 9.88 TNF TLR2 IL6 IL17A CRP
12 regulation of insulin secretion GO:0050796 9.87 TNF IL6 IL1B
13 negative regulation of interleukin-6 production GO:0032715 9.87 TNF TLR4 IL10
14 response to glucocorticoid GO:0051384 9.87 TNF IL6 IL10
15 positive regulation of interferon-gamma production GO:0032729 9.86 TNF TLR4 IL1B
16 positive regulation of T cell proliferation GO:0042102 9.86 IL6 IL1B CD4
17 humoral immune response GO:0006959 9.85 TNF IL6 CCR6
18 positive regulation of interleukin-1 beta production GO:0032731 9.85 TNF TLR4 IL6 IL17A
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.84 TNF TLR4 IL1B
20 positive regulation of interleukin-12 production GO:0032735 9.83 TLR4 TLR2 IL17A
21 positive regulation of interleukin-10 production GO:0032733 9.83 TLR4 TLR2 IL6
22 positive regulation of JAK-STAT cascade GO:0046427 9.81 TNF IL6 IL10
23 positive regulation of chemokine production GO:0032722 9.81 TNF TLR4 TLR2 IL6
24 negative regulation of neurogenesis GO:0050768 9.8 TNF IL6 IL1B
25 positive regulation of interleukin-6 production GO:0032755 9.8 TNF TLR4 TLR2 IL6 IL1B IL17A
26 cellular response to lipopolysaccharide GO:0071222 9.8 VIM TNF TLR4 IL6 IL1B IL10
27 positive regulation of glial cell proliferation GO:0060252 9.77 TNF IL6 IL1B
28 positive regulation of interleukin-8 production GO:0032757 9.77 TNF TLR4 TLR2 IL6 IL1B
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.76 TNF IL1B IL10
30 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 TNF TLR4 TLR2 IL1B
31 cytokine-mediated signaling pathway GO:0019221 9.76 VIM TNF IL6 IL1B IL17A IL10
32 positive regulation of neuroinflammatory response GO:0150078 9.73 TNF IL6 IL1B
33 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.73 TNF TLR4 IL6 IL17A
34 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.71 TNF TLR4
35 response to molecule of bacterial origin GO:0002237 9.71 TLR2 IL10 CXCL8
36 regulation of establishment of endothelial barrier GO:1903140 9.7 TNF IL1B
37 cellular response to lipoteichoic acid GO:0071223 9.7 TLR4 TLR2
38 negative regulation of lipid storage GO:0010888 9.7 TNF IL6 CRP
39 endothelial cell apoptotic process GO:0072577 9.69 TNF IL10
40 negative regulation of cytokine production involved in immune response GO:0002719 9.68 TNF IL10
41 intestinal epithelial structure maintenance GO:0060729 9.67 TLR4 IL17A
42 positive regulation of fever generation GO:0031622 9.67 TNF IL1B
43 vascular endothelial growth factor production GO:0010573 9.67 TNF IL6 IL1B
44 sequestering of triglyceride GO:0030730 9.66 TNF IL1B
45 positive regulation of matrix metallopeptidase secretion GO:1904466 9.65 TLR4 TLR2
46 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.64 TNF IL1B
47 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.63 TLR4 TLR2
48 inflammatory response GO:0006954 9.61 TNF TLR4 TLR2 IL6 IL1B IL17A
49 immune response GO:0006955 9.32 TNF TLR4 TLR2 IL6 IL1B IL17A

Molecular functions related to Klebsiella Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 VIM UBAC1 TNF TLR4 TLR2 PLAT
2 identical protein binding GO:0042802 9.86 VIM TNF TLR4 TLR2 ICOSLG CRP
3 signaling receptor activity GO:0038023 9.62 TLR4 TLR2 CD4 CCR6
4 lipopolysaccharide receptor activity GO:0001875 9.16 TLR4 TLR2
5 cytokine activity GO:0005125 9.1 TNF IL6 IL1B IL17A IL10 CXCL8
Sources

Sources for Klebsiella Pneumonia

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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