MCID: KLB003
MIFTS: 35

Klebsiella Pneumonia

Categories: Infectious diseases, Respiratory diseases
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Aliases & Classifications for Klebsiella Pneumonia

Summaries for Klebsiella Pneumonia

Disease Ontology: 11 A bacterial pneumonia involving Klebsiella pneumoniae infection. Patients with Klebsiella pneumonia tend to cough up a characteristic sputum that is said to resemble red-currant jelly. Klebsiella pneumonia tends to affect people with underlying diseases, such as alcoholism, diabetes and chronic lung disease. The symptoms include high fever, rigors and pleuritic pain, and hemoptysis.

MalaCards based summary: Klebsiella Pneumonia, also known as pneumonia due to klebsiella pneumoniae, is related to bacteremia 2 and pneumonia. An important gene associated with Klebsiella Pneumonia is LACTB (Lactamase Beta), and among its related pathways/superpathways is Complement cascade. The drugs Tazobactam and Piperacillin have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and kidney.

Related Diseases for Klebsiella Pneumonia

Diseases related to Klebsiella Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 459)
# Related Disease Score Top Affiliating Genes
1 bacteremia 2 30.7 LACTB CRP
2 pneumonia 30.5 LACTB GPT CRP ALB
3 endophthalmitis 30.3 CRP ALB
4 meningitis 30.1 LACTB CRP ALB
5 bacterial pneumonia 29.8 LACTB GPT CRP ALB
6 dysentery 29.7 CRP ALB
7 lung abscess 29.7 LACTB GPT CRP ALB
8 polyarteritis nodosa 29.5 GPT CRP
9 epidural abscess 29.5 F3 CRP ALB
10 necrotizing fasciitis 29.5 F3 CRP ALB
11 pleural empyema 29.5 GPT CRP ALB
12 thrombophlebitis 29.5 F3 CRP ALB
13 bacterial sepsis 29.5 F3 CRP ALB
14 bronchopneumonia 29.5 GPT CRP ALB
15 thrombocytosis 29.5 F3 CRP ALB
16 alcohol use disorder 29.5 GPT CRP ALB
17 pulmonary embolism 29.5 F3 CRP ALB
18 urinary tract infection 29.4 GPT F3 CRP ALB
19 critical covid-19 29.3 GPT F3 CRP
20 respiratory failure 29.3 GPT F3 CRP ALB
21 pyelonephritis 29.2 GPT CRP ALB
22 septic arthritis 29.2 GPT CRP ALB
23 alcoholic hepatitis 29.2 GPT CRP ALB
24 pancytopenia 29.2 GPT CRP ALB
25 severe covid-19 28.9 GPT F3 CRP ALB
26 cellulitis 28.6 LACTB GPT F3 CRP ALB
27 klebsiella infection 11.0
28 suppressor of tumorigenicity 11 10.2
29 48,xyyy 10.2
30 aspergillosis 10.2
31 intracranial abscess 10.2 LACTB CRP
32 third-degree atrioventricular block 10.2
33 lactic acidosis 10.2
34 epiglottitis 10.2 LACTB CRP
35 maxillary sinusitis 10.1 LACTB CRP
36 achenbach syndrome 10.1 F3 CRP
37 synovial angioma 10.1 F3 CRP
38 femoral neuropathy 10.1 F3 CRP
39 blue toe syndrome 10.1 F3 CRP
40 renal pelvis squamous cell carcinoma 10.1 F3 CRP
41 subclavian steal syndrome 10.1 F3 CRP
42 waterhouse-friderichsen syndrome 10.1 F3 CRP
43 cavernous sinus thrombosis 10.1 F3 CRP
44 nonbacterial thrombotic endocarditis 10.1 F3 CRP
45 pericoronitis 10.1 F3 CRP
46 lemierre's syndrome 10.1 F3 CRP
47 branch retinal artery occlusion 10.1 F3 CRP
48 hemopericardium 10.1 F3 CRP
49 acute cor pulmonale 10.1 F3 CRP
50 acute pulmonary heart disease 10.1 F3 CRP

Graphical network of the top 20 diseases related to Klebsiella Pneumonia:



Diseases related to Klebsiella Pneumonia

Symptoms & Phenotypes for Klebsiella Pneumonia

Drugs & Therapeutics for Klebsiella Pneumonia

Drugs for Klebsiella Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tazobactam Approved Phase 4 89786-04-9 123630
2
Piperacillin Approved Phase 4 66258-76-2 43672
3
Meropenem Approved, Investigational Phase 4 119478-56-7, 96036-03-2 441130
4
Polymyxin B Approved, Vet_approved Phase 4 1405-20-5, 1404-26-8 4868
5
Colistin Approved Phase 4 1264-72-8, 1066-17-7 5311054
6
Tigecycline Approved Phase 4 220620-09-7 5282044
7
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
8
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1, 93107-08-5 2764
9
Ceftriaxone Approved Phase 4 73384-59-5 5479530
10
Levoleucovorin Approved, Experimental, Investigational Phase 4 68538-85-2, 58-05-9, 73951-54-9 149436 6006
11
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
12
Sulfamethoxazole Approved Phase 4 723-46-6 5329
13
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
14 beta-Lactamase Inhibitors Phase 4
15 Piperacillin, Tazobactam Drug Combination Phase 4
16 Pharmaceutical Solutions Phase 4
17 Polymyxins Phase 4
18 Gentamicins Phase 4
19 Anti-Bacterial Agents Phase 4
20 Anti-Infective Agents Phase 4
21 Antibiotics, Antitubercular Phase 4
22 Folic Acid Antagonists Phase 4
23 Folate Phase 4
24 Liver Extracts Phase 4
25 Vitamin B9 Phase 4
26 Antiprotozoal Agents Phase 4
27 Antiparasitic Agents Phase 4
28 Vitamin B Complex Phase 4
29 Antimalarials Phase 4
30 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
31 Cytochrome P-450 Enzyme Inhibitors Phase 4
32
Sitafloxacin Experimental, Investigational Phase 2, Phase 3 163253-35-8
33 Vaccines Phase 1, Phase 2
34
Imipenem Approved 74431-23-5, 64221-86-9 104838
35
Vancomycin Approved 1404-90-6 14969
36
Framycetin Approved, Experimental, Vet_approved 1404-04-2, 119-04-0, 3947-65-7 413349 8378
37
Streptomycin Approved, Vet_approved 57-92-1 19649

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Piperacillin/Tazobactam Versus Carbapenems in Non-bacteremic Urinary Tract Infections Due to Extended-spectrum β-lactamase (ESBL)-Producing Escherichia Coli or Klebsiella Pneumoniae - (CAPITIS Study) Unknown status NCT03891433 Phase 4 Meropenem;Ertapenem 1000 MG;Piperacillin, Tazobactam 4-0.5G Solution for Injection
2 Comparative Clinical Study Between Colistin-Tigecycline Combined Therapy Versus Colistin-Meropenem Combined Therapy in Treatment of Blood Stream Infections With Multidrug-Resistant Klebsiella Pneumoniae Unknown status NCT04489459 Phase 4 Colistin;Meropenem;Tigecycline
3 SELECTIVE DIGESTIVE DECONTAMINATION USING ORAL GENTAMICIN AND ORAL POLYMYXIN E FOR ERADICATION OF CARBAPENEM-RESISTANT KLEBSIELLA PNEUMONIAE CARRIAGE IN HOSPITALIZED PATIENTS Unknown status NCT01761487 Phase 4
4 A Multi-centre Randomised Open-label Active Comparator-controlled Non-inferiority Trial Comparing Oral to Intravenous Antibiotics in the Early Management of Klebsiella Pneumoniae Liver Abscess Completed NCT01723150 Phase 4 Ciprofloxacin;Ceftriaxone;Trimethoprim/sulfamethoxazole;Ertapenem
5 Sitafloxacin and Ertapenem Treatment for Acute Urinary Tract Infection Caused by E. Coli or K. Pneumoniae in Post-kidney Transplantation Patients Recruiting NCT02729116 Phase 2, Phase 3 Sitafloxacin;Ertapenem
6 Safety and Efficacy Study of Eradication of Carbapenem Resistant Klebsiella Pneumonia From the Gastrointestinal Tract by Probiotics. Unknown status NCT00722410 Phase 1, Phase 2 Polyethylene glycol
7 Safety and Immunogenicity of a Klebsiella Pneumoniae Tetravalent Bioconjugate Vaccine (Kleb4V) Administered to Healthy Adults: A FTIH Phase I/II Randomized and Controlled Study Completed NCT04959344 Phase 1, Phase 2
8 Randomized, Superiority, Double Blind Controlled With Placebo, Clinical Trial, to Demonstrate the Effectiveness of Fecal Microbiota Transplantation for Selective Intestinal Decolonization of Patients Colonized by Klebsiella Pneumoniae Carbapenemase (KPC)-Producing Recruiting NCT04760665 Phase 2
9 Analysis on the Infection Risk, Prognosis, and Drug Sensitivity of Klebsiella Pneumoniae. Unknown status NCT04337840
10 Comparison of Clinical Outcomes in Bloodstream Infections With Carbapenem Hetero-resistant vs Carbapenem Resistant Klebsiella Pneumoniae (COMBAT) Unknown status NCT04229498 Monotherapy and combination therapy (all antibiotics that are given by attending pysicians and can be active against Klebsiella pneumoniae will be evaluated)
11 Klebsiella Pneumoniae Infection in China: Epidemiology, Molecular Characteristics, Treatment, and Outcome Unknown status NCT03598543
12 WGS-guided Tracking and Infection Control Measures of Carbapenem-resistant Klebsiella Pneumoniae Unknown status NCT04413305
13 Epidemiological Characteristics and Treatment Protocol for Carbapenem-Resistant Klebsiella Pneumoniae in China Unknown status NCT03245632
14 Effects of Piperacillin-Tazobactam Use on the Prevalence Rate of Extended-Spectrum Beta-Lactamase (ESBL) Producing Escherichia Coli and Klebsiella Pneumoniae in Hematology and Oncology Units. Completed NCT00167999 piperacillin-tazobactam
15 Antibiotic Intervention Trial in a Medical Intensive Care Unit to Reduce the Acquisition of Vancomycin-Resistant Enterococci and ESBL Producing Escherichia Coli and Klebsiella Pneumoniae. Completed NCT00167986 vancomycin-resistant enterococci and ESBL
16 Community - Associated Extended-spectrum Beta-lactamases (ESBL) Completed NCT00363220
17 Efficacy of Intestinal Decontamination in Patients Colonized by Carbapenem-resistant Klebsiella Pneumoniae and Colistin Completed NCT02604849 Neomycin;Streptomycin;Gentamicins
18 Risk Factors for Quinolone Resistance Among Extended-Spectrum Beta-Lactamase-Producing Klebsiella Species Completed NCT00518661
19 Double Carbapenem as Rescue Strategy for the Treatment of Severe Carbapenemase-Producing Klebsiella Pneumoniae Infections: A Two-Center Matched Case-Control Study Completed NCT03094494
20 Turkish Prospective Cohort Study on Carbapenem Resistant Klebsiella Pneumonia Bacteremia: a National Multicenter Observational Study Completed NCT03597841 Combination therapy
21 Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features Completed NCT01139112
22 A Randomized Open Label Study Evaluating the Role of Oral Antibiotics in an Aim to Eradicate Carrier State of Carbapenem- Resistant Klebsiella Pneumonia (KPC). Completed NCT01266499 Colistin (Polymyxin E) 100mg x 4/d;both medications;will not receive PO treatment;PO Garamycin 80mg x 4/d
23 Sites of Colonization in Hospitalized Patients With Infections Caused by Extended-Spectrum Beta-Lactamase Producing Escherichia Coli and Klebsiella Pneumoniae Completed NCT01324726
24 Antimicrobial Resistance Rate In Escherichia Coli And Klebsiella Pneumonia : A Retrospective Study Completed NCT04196387
25 The Incidence of Extended-spectrum β-lactamase (ESBL) Klebsiella Pneumonia in Patient on Renal Replacement Therapy Completed NCT01612182
26 Type VI Secretion System in Klebsiella Pneumoniae Relation to Antibiotic Resistance and Biofilm Formation Recruiting NCT05516654
27 Prognosis of Klebsiella ESBL Sepsis: Role of 2-HYDRoxy-myristate in Endotoxin Structure Active, not recruiting NCT05193045

Search NIH Clinical Center for Klebsiella Pneumonia

Cochrane evidence based reviews: klebsiella infections

Genetic Tests for Klebsiella Pneumonia

Anatomical Context for Klebsiella Pneumonia

Organs/tissues related to Klebsiella Pneumonia:

MalaCards : Lung, Liver, Kidney, Whole Blood, Bone Marrow, Spinal Cord, Neutrophil

Publications for Klebsiella Pneumonia

Articles related to Klebsiella Pneumonia:

(show top 50) (show all 1577)
# Title Authors PMID Year
1
Nosocomial bloodstream infections in a pediatric intensive care unit: 3-year survey. 53 62
17534230 2007
2
Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases. 53 62
15206050 2004
3
FeoC from Klebsiella pneumoniae uses its iron sulfur cluster to regulate the GTPase activity of the ferrous iron channel. 62
36182071 2023
4
Anti-microbial and cytotoxic activity of ZzAMP, a serine protease inhibitor (SPI) with nutraceutical potential from rhizomes of medicinal plant, Zingiber zerumbet. 62
35105207 2022
5
Chemical compositions, antibacterial, antifungal and cytotoxic effects of Alhagi mannifera five extracts. 62
34384010 2022
6
Reconstructing ethanol oxidation pathway in Pseudomonas putida KT2440 for bio-upgrading of ethanol to biodegradable polyhydroxybutanoates. 62
36174870 2022
7
Sequencing analysis of tigecycline resistance among tigecycline non-susceptible in three species of G-ve bacteria isolated from clinical specimens in Baghdad. 62
36207501 2022
8
Molecular docking studies and biological evaluation of isoxazole-carboxamide derivatives as COX inhibitors and antimicrobial agents. 62
36345437 2022
9
Biogenic synthesis of ZnO nanoparticles mediated from Borassus flabellifer (Linn): antioxidant, antimicrobial activity against clinical pathogens, and photocatalytic degradation activity with molecular modeling. 62
35040048 2022
10
MCR-1-dependent lipid remodelling compromises the viability of Gram-negative bacteria. 62
35437117 2022
11
Associated microbiota and treatment of severe fever with thrombocytopenia syndrome complicated with infections. 62
35945160 2022
12
Exploiting the Acidic Extracellular pH: Evaluation of Streptococcus salivarius M18 Postbiotics to Target Cancer Cells. 62
34080175 2022
13
Chemical Profiling and In Vitro Antiurolithiatic Activity of Pleurolobus gangeticus (L.) J. St.- Hil. ex H. Ohashi & K. Ohashi Along with Its Antioxidant and Antibacterial Properties. 62
35687306 2022
14
Comparative Study of Antimicrobial Activity of Silver, Gold, and Silver/Gold Bimetallic Nanoparticles Synthesized by Green Approach. 62
36431998 2022
15
In-silico functional and structural annotation of hypothetical protein from Klebsiella pneumonia: A potential drug target. 62
35839717 2022
16
A novel family of non-secreted tridecaptin lipopeptide produced by Paenibacillus elgii. 62
35864259 2022
17
Multidrug resistant bacterial infections in severely ill COVID-19 patients admitted in a national referral and teaching hospital, Kenya. 62
36418990 2022
18
Identification and Antimicrobial Resistance in Klebsiella spp. Isolates from Turkeys in Poland between 2019 and 2022. 62
36428385 2022
19
Antibacterial studies of [email protected]@GO nanocomposites and their effects on fouling and dye rejection in PES UF membranes. 62
36468096 2022
20
Antimicrobial Applications of Green Synthesized Bimetallic Nanoparticles from Ocimum basilicum. 62
36432648 2022
21
Efficacy predictors of third-generation cephalosporins in treating spontaneous bacterial peritonitis. 62
36221348 2022
22
8-Amino-7-(aryl/hetaryl)fluoroquinolones. An emerging set of synthetic antibacterial agents. 62
36278497 2022
23
Studies on antimicrobial stress with reference to biofilm formation of faecal microbial communities from Apatani tribe of Arunachal Pradesh. 62
36244849 2022
24
A cross-sectional study on clinical, demographic, microbiological, and radiological profile of bronchiectasis patients attending a tertiary care teaching center. 62
36460391 2022
25
Rapid Bacterial Identification and Drug Sensitivity Test Methods for Pathogens in Positive Blood Cultures. 62
36250829 2022
26
Oral microbiota associated with gingiva of healthy, gingivitis and periodontitis cases. 62
35988883 2022
27
Neonatal Healthcare-Associated Conjunctivitis: A Descriptive Study from Saudi Arabia. 62
36295608 2022
28
Maternal colonization and early-onset neonatal bacterial sepsis in the Gambia, West Africa: a genomic analysis of vertical transmission. 62
36243352 2022
29
INTRAPULMONARY TREATMENT WITH A NOVEL TLR4 AGONIST CONFERS PROTECTION AGAINST KLEBSIELLA PNEUMONIA. 62
36018281 2022
30
A review: Virulence factors of Klebsiella pneumonia as emerging infection on the food chain. 62
36341059 2022
31
Preparation and evaluation of a new combined conjugated vaccine against Klebsiella pneumonia and Pseudomonas aeruginosa. 62
35652238 2022
32
A Rare but Life-Threatening Case of Fournier's Gangrene Caused by Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitor, Empagliflozin. 62
36262942 2022
33
Xanthogranulomatous inflammation caused by K. pneumonia and nocardiosis mimicking a uterine tumor and invading the ureter and colon: A case report and review of the literature. 62
36088063 2022
34
Evaluation of Green Silver Nanoparticles Fabricated by Spirulina platensis Phycocyanin as Anticancer and Antimicrobial Agents. 62
36294927 2022
35
Community-acquired pneumonia-causing bacteria and antibiotic resistance rate among Vietnamese patients: A cross-sectional study. 62
36086715 2022
36
Effect of Cu Modified Textile Structures on Antibacterial and Antiviral Protection. 62
36079542 2022
37
Trends of Bloodstream Infections in a University Hospital During 12 Years. 62
36185018 2022
38
Urgent nephrectomy for rapidly progressive disseminated metastatic Hypermucoid Klebsiella. 62
35846515 2022
39
Silver Nanoparticles Conjugated with Colistin Enhanced the Antimicrobial Activity against Gram-Negative Bacteria. 62
36144516 2022
40
Biomimetic facile synthesis of zinc oxide and copper oxide nanoparticles from Elaeagnus indica for enhanced photocatalytic activity. 62
35472463 2022
41
Antibiotic Resistance during COVID-19: A Systematic Review. 62
36231256 2022
42
Promising Endophytic Alternaria alternata from Leaves of Ziziphus spina-christi: Phytochemical Analyses, Antimicrobial and Antioxidant Activities. 62
35579741 2022
43
Demographics, Radiological Findings, and Clinical Outcomes of Klebsiella pneumonia vs. Non-Klebsiella pneumoniae Pyogenic Liver Abscess: A Systematic Review and Meta-Analysis with Trial Sequential Analysis. 62
36145408 2022
44
Metagenomics-based antibiotic resistance genes diversity and prevalence risk revealed by pathogenic bacterial host in Taihu Lake, China. 62
34292452 2022
45
Green synthesis of silver nanoparticles from plant latex and their antibacterial and photocatalytic studies. 62
33825663 2022
46
Prevalence, Antibiogram, and Associated Factors of Bacteria Isolated From Presumptive Meningitis Patients at Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia. 62
36185882 2022
47
Deep Sternal Wound Infection After Open-heart Cardiac Surgery and Vacuum-Assisted Closure Therapy: a Single-center Study. 62
36313952 2022
48
In-vitro determination of antimicrobial activities of Eruca sativa seed oil against antibiotic-resistant gram-negative clinical isolates from neonates: a future prospect. 62
36030221 2022
49
GC-MS and in vitro antibacterial potential of Cinnamomum camphora essential oil against some clinical antibiotic-resistant bacterial isolates. 62
35993631 2022
50
Design, Synthesis and Mechanistic Studies of Novel Isatin-Pyrazole Hydrazone Conjugates as Selective and Potent Bacterial MetAP Inhibitors. 62
36009995 2022

Variations for Klebsiella Pneumonia

Expression for Klebsiella Pneumonia

Search GEO for disease gene expression data for Klebsiella Pneumonia.

Pathways for Klebsiella Pneumonia

Pathways related to Klebsiella Pneumonia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.36 MASP1 CRP ALB

GO Terms for Klebsiella Pneumonia

Sources for Klebsiella Pneumonia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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