Klebsiella Pneumonia

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Klebsiella Pneumonia

Summaries for Klebsiella Pneumonia

Disease Ontology : 12 A bacterial pneumonia involving Klebsiella pneumoniae infection. Patients with Klebsiella pneumonia tend to cough up a characteristic sputum that is said to resemble red-currant jelly. Klebsiella pneumonia tends to affect people with underlying diseases, such as alcoholism, diabetes and chronic lung disease. The symptoms include high fever, rigors and pleuritic pain, and hemoptysis.

MalaCards based summary : Klebsiella Pneumonia, also known as pneumonia due to klebsiella pneumoniae, is related to spondylitis and bacteremia 2. An important gene associated with Klebsiella Pneumonia is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Cytokine production by Th17 cells in CF (Mouse model) and IL-17 Family Signaling Pathways. The drugs leucovorin and Ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and colon, and related phenotype is immune system.

Wikipedia : 74 Klebsiella pneumoniae is a Gram-negative, non-motile, encapsulated, lactose-fermenting, facultative... more...

Related Diseases for Klebsiella Pneumonia

Diseases related to Klebsiella Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 634)
# Related Disease Score Top Affiliating Genes
1 spondylitis 31.3 IL17A CRP CCR6
2 bacteremia 2 31.2 LACTB CRP
3 peritonitis 31.0 IL17A CRP ALB
4 epidural abscess 31.0 CRP ALB
5 mastitis 31.0 IL17A CCR6 ALB
6 orbital cellulitis 31.0 SNORD35A CRP
7 hypopyon 30.8 IL17A CRP
8 acute cystitis 30.8 CRP CD40LG CCR6 ALB
9 bacterial infectious disease 30.7 IL17A CRP CD40LG CCR6
10 mediastinitis 30.6 LACTB CRP ALB
11 gastroenteritis 30.6 LACTB CRP ALB
12 bacterial meningitis 30.5 LACTB IL17A CRP ALB
13 cardiac rupture 30.4 PLAT CRP
14 spondyloarthropathy 1 30.4 IL17A CRP CD40LG CCR6
15 endocarditis 30.4 PLAT LACTB IL17A CRP ALB
16 bacteriuria 30.3 CRP CD40LG ALB
17 pneumonia 30.3 LACTB IL17A CRP CD40LG ALB
18 appendicitis 30.3 IL17A CRP ALB
19 urinary tract obstruction 30.2 CRP CCR6 ALB
20 ecthyma 30.2 CRP CD40LG
21 neutropenia 30.2 LACTB CRP CD40LG ALB
22 bronchopneumonia 30.2 CRP CD40LG ALB
23 iridocyclitis 30.1 IL17A CRP CD40LG
24 meningitis 30.1 LACTB IL17A CRP CD40LG ALB
25 vasculitis 30.1 IL17A CRP CD40LG
26 cardiac tamponade 30.0 PLAT CRP ALB
27 toxic megacolon 30.0 CRP CCR6 ALB
28 cerebritis 30.0 CRP CD40LG
29 reactive arthritis 30.0 IL17A CRP CCR6
30 diverticulitis 30.0 CRP CCR6 ALB
31 pericarditis 30.0 CRP CD40LG ALB
32 cellulitis 30.0 IL17A CRP CD40LG CCR6
33 lung abscess 29.9 LACTB CRP CD40LG ALB
34 thrombophlebitis 29.9 PLAT CRP CD40LG ALB
35 volvulus of midgut 29.9 CRP ALB
36 crohn's disease 29.9 IL17A CRP CCR6 ALB
37 arthritis 29.9 IL17RA IL17A CRP CCR6 ALB
38 pulmonary disease, chronic obstructive 29.9 IL17A CRP CCR6 ALB
39 pyuria 29.9 CRP CD40LG ALB
40 biliary tract disease 29.8 CRP CD40LG CCR6 ALB
41 respiratory failure 29.8 CRP CD40LG CCR6 ALB
42 bacterial conjunctivitis 29.8 CRP CD40LG
43 meningoencephalitis 29.8 CRP CD40LG CCR6 ALB
44 pulmonary embolism 29.8 PLAT CRP CD40LG ALB
45 tenosynovitis 29.7 CRP CD40LG
46 spondyloarthropathy 29.7 IL17F IL17A CCR6
47 sickle cell anemia 29.7 CRP CD40LG ALB
48 splenic abscess 29.7 LACTB CRP CD40LG ALB
49 pleural empyema 29.7 MUCL1 CRP CD40LG ALB
50 fournier gangrene 29.7 CD40LG ALB

Graphical network of the top 20 diseases related to Klebsiella Pneumonia:

Diseases related to Klebsiella Pneumonia

Symptoms & Phenotypes for Klebsiella Pneumonia

MGI Mouse Phenotypes related to Klebsiella Pneumonia:

# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 ALB CCR6 CD40LG CRP IL17A IL17B

Drugs & Therapeutics for Klebsiella Pneumonia

Drugs for Klebsiella Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
leucovorin Approved Phase 4 58-05-9 6006 143
Ceftriaxone Approved Phase 4 73384-59-5 5361919 5479530
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
Sulfamethoxazole Approved Phase 4 723-46-6 5329
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
Tazobactam Approved Phase 4 89786-04-9 123630
Piperacillin Approved Phase 4 66258-76-2 43672
Ceftaroline fosamil Approved, Investigational Phase 4 229016-73-3
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
10 Cytochrome P-450 Enzyme Inhibitors Phase 4
11 Folic Acid Antagonists Phase 4
12 Vitamin B Complex Phase 4
13 Liver Extracts Phase 4
14 Antiprotozoal Agents Phase 4
15 Antiparasitic Agents Phase 4
16 Folate Phase 4
17 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
18 Antimalarials Phase 4
19 Vitamin B9 Phase 4
20 Anti-Retroviral Agents Phase 4
21 Pharmaceutical Solutions Phase 4
22 Piperacillin, Tazobactam Drug Combination Phase 4
23 beta-Lactamase Inhibitors Phase 4
24 Sitafloxacin Experimental, Investigational Phase 2, Phase 3 163253-35-8
Cefdinir Approved Phase 2 91832-40-5 6915944
Cefixime Approved, Investigational Phase 2 79350-37-1 5362065 54362
Cephalexin Approved, Investigational, Vet_approved Phase 2 15686-71-2 27447
Colistin Approved 1264-72-8, 1066-17-7 5311054
Vancomycin Approved 1404-90-6 14969 441141
Neomycin Approved, Vet_approved 1404-04-2 8378
Streptomycin Approved, Vet_approved 57-92-1 19649
Ertapenem Approved, Investigational 153832-46-3 150610
Meropenem Approved, Investigational 96036-03-2, 119478-56-7 441130 64778
Imipenem Approved 74431-23-5, 64221-86-9 104838
35 Gentamicins
36 Polymyxins
37 Anti-Bacterial Agents
38 Anti-Infective Agents
39 Antibiotics, Antitubercular

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
2 Use Of High Dose Colistin in Multi Drug Resistant Gram Negative Infections in Critically Ill Adult Patients. Randomized Controlled Clinical Trial Unknown status NCT02162966 Phase 4 High Dose Colistin;Standard Dose Colistin
3 A Multi-centre Randomised Open-label Active Comparator-controlled Non-inferiority Trial Comparing Oral to Intravenous Antibiotics in the Early Management of Klebsiella Pneumoniae Liver Abscess Completed NCT01723150 Phase 4 Ciprofloxacin;Ceftriaxone;Trimethoprim/sulfamethoxazole;Ertapenem
4 Randomized Clinical Trial to Assess Whether the Duration of Cotrimoxazole Preventive Therapy in HIV Patients With CD4 Counts >350 CD4 Cells/µL by Antiretroviral Treatment Influences the Rate of Carriage of Multidrug-resistant Bacteria Completed NCT03087890 Phase 4 Cotrimoxazole;Placebo
5 Ceftaroline Pharmacokinetics in Critically Ill Patients Receiving Continuous Renal Replacement Therapy Recruiting NCT04152694 Phase 4
6 Piperacillin/Tazobactam Versus Carbapenems in Non-bacteremic Urinary Tract Infections Due to Extended-spectrum β-lactamase (ESBL)-Producing Escherichia Coli or Klebsiella Pneumoniae - (CAPITIS Study) Recruiting NCT03891433 Phase 4 Meropenem;Ertapenem 1000 MG;Piperacillin, Tazobactam 4-0.5G Solution for Injection
7 Sitafloxacin and Ertapenem Treatment for Acute Urinary Tract Infection Caused by E. Coli or K. Pneumoniae in Post-kidney Transplantation Patients Recruiting NCT02729116 Phase 2, Phase 3 Sitafloxacin;Ertapenem
8 Safety and Efficacy Study of Eradication of Carbapenem Resistant Klebsiella Pneumonia From the Gastrointestinal Tract by Probiotics. Unknown status NCT00722410 Phase 1, Phase 2 Polyethylene glycol
9 Targeted Clinical Trials to Reduce the Risk of Antimicrobial Resistance The SCOUT Study: "Short Course Therapy for Urinary Tract Infections in Children" Active, not recruiting NCT01595529 Phase 2 Cefixime;Cephalexin;Trimethoprim/Sulfamethoxazole
10 Oral and Tracheal Cultures in Pediatric ICU Patients Compared to Healthy Children Unknown status NCT03418272
11 Epidemiological Characteristics and Treatment Protocol for Carbapenem-Resistant Klebsiella Pneumoniae in China Unknown status NCT03245632
12 The Impact of Targeted Therapy on Microorganism in Patients With Psoriasis Unknown status NCT01504113
13 A Randomized Open Label Study Evaluating the Role of Oral Antibiotics in an Aim to Eradicate Carrier State of Carbapenem- Resistant Klebsiella Pneumonia (KPC). Completed NCT01266499 Colistin (Polymyxin E) 100mg x 4/d;both medications;will not receive PO treatment;PO Garamycin 80mg x 4/d
14 The Incidence of Extended-spectrum β-lactamase (ESBL) Klebsiella Pneumonia in Patient on Renal Replacement Therapy Completed NCT01612182
15 Antimicrobial Resistance Rate In Escherichia Coli And Klebsiella Pneumonia : A Retrospective Study Completed NCT04196387
16 Turkish Prospective Cohort Study on Carbapenem Resistant Klebsiella Pneumonia Bacteremia: a National Multicenter Observational Study Completed NCT03597841 Combination therapy
17 Double Carbapenem as Rescue Strategy for the Treatment of Severe Carbapenemase-Producing Klebsiella Pneumoniae Infections: A Two-Center Matched Case-Control Study Completed NCT03094494
18 Antibiotic Intervention Trial in a Medical Intensive Care Unit to Reduce the Acquisition of Vancomycin-Resistant Enterococci and ESBL Producing Escherichia Coli and Klebsiella Pneumoniae. Completed NCT00167986 vancomycin-resistant enterococci and ESBL
19 Detecting Infections Rapidly and Easily for Bacteremia Trial (DIREBT)-Part I (Prospective Collection and Freezing of Whole Blood Specimens) Completed NCT01919762
20 Efficacy of Intestinal Decontamination in Patients Colonized by Carbapenem-resistant Klebsiella Pneumoniae and Colistin Completed NCT02604849 Neomycin;Streptomycin;Gentamicins
21 Effects of Piperacillin-Tazobactam Use on the Prevalence Rate of Extended-Spectrum Beta-Lactamase (ESBL) Producing Escherichia Coli and Klebsiella Pneumoniae in Hematology and Oncology Units. Completed NCT00167999 piperacillin-tazobactam
22 Risk Factors for Quinolone Resistance Among Extended-Spectrum Beta-Lactamase-Producing Klebsiella Species Completed NCT00518661
23 Bacterial Transmission Surveillance in Neonatal Intensive Care Unit: Transmission Dynamics and Drug Resistance Patterns Completed NCT02401204
24 Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features Completed NCT01139112
25 Prospective Observational Study, Impact of Plasma Levels of Colistin in Patients With Carbapenem Resistant Acinetobacter Baumannii Infection Completed NCT02482961 colistimethate sodium
26 Community - Associated Extended-spectrum Beta-lactamases (ESBL) Completed NCT00363220
27 Sites of Colonization in Hospitalized Patients With Infections Caused by Extended-Spectrum Beta-Lactamase Producing Escherichia Coli and Klebsiella Pneumoniae Completed NCT01324726
28 Exploratory Study on the Ocular Surface Microbiome and Correlation to Clinical Parameters Completed NCT02161341
29 WGS-guided Tracking and Infection Control Measures of Carbapenem-resistant Klebsiella Pneumoniae Recruiting NCT04413305
30 Klebsiella Pneumoniae Infection in China: Epidemiology, Molecular Characteristics, Treatment, and Outcome Recruiting NCT03598543
31 Analysis on the Infection Risk, Prognosis, and Drug Sensitivity of Klebsiella Pneumoniae. Not yet recruiting NCT04337840
32 Development of Risk Score Model and Decision Tree Algorithm for Predicting Bloodstream Infections (BSIs) or Other Invasive Infections With Carbapenem Resistant Klebisella Penumoniae (CRKp) in CRKp Colonized Patients (DETERMINE) Not yet recruiting NCT04229511
33 Comparison of Clinical Outcomes in Bloodstream Infections With Carbapenem Hetero-resistant vs Carbapenem Resistant Klebsiella Pneumoniae (COMBAT) Not yet recruiting NCT04229498 Monotherapy and combination therapy (all antibiotics that are given by attending pysicians and can be active against Klebsiella pneumoniae will be evaluated)

Search NIH Clinical Center for Klebsiella Pneumonia

Cochrane evidence based reviews: klebsiella infections

Genetic Tests for Klebsiella Pneumonia

Anatomical Context for Klebsiella Pneumonia

MalaCards organs/tissues related to Klebsiella Pneumonia:

Lung, Liver, Colon, Kidney, Prostate, Neutrophil, Bone

Publications for Klebsiella Pneumonia

Articles related to Klebsiella Pneumonia:

(show top 50) (show all 1118)
# Title Authors PMID Year
Nosocomial bloodstream infections in a pediatric intensive care unit: 3-year survey. 61 54
17534230 2007
Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases. 61 54
15206050 2004
Therapeutic sildenafil inhibits pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats. 61
31967915 2020
The type I-E CRISPR-Cas system influences the acquisition of blaKPC-IncF plasmid in Klebsiella pneumonia. 61
32393110 2020
A computational subtractive genome analysis for the characterization of novel drug targets in Klebsiella pneumonia strain PittNDM01. 61
32423883 2020
Evaluating the effect of silver nanoparticles on bacteriophage lytic infection cycle-a mechanistic understanding. 61
32504909 2020
The determination of gyrA and parC mutations and the prevalence of plasmid-mediated quinolone resistance genes in carbapenem resistant Klebsiella pneumonia ST11 and ST76 strains isolated from patients in Heilongjiang Province, China. 61
32278145 2020
Synthesis of bio-mediated silver nanoparticles from Silybum marianum and their biological and clinical activities. 61
32409047 2020
The endolysin of the Acinetobacter baumannii phage vB_AbaP_D2 shows broad antibacterial activity. 61
32519416 2020
Sequential time-kill: a simple experimental trick to discriminate between PK/PD models with distinct heterogeneous sub-populations versus homogenous population with adaptive resistance. 61
32513802 2020
6 Nitro-1-benzylquinolones exhibiting specific anti-tubercular activity. 61
32558257 2020
Synthesis, characterization and antimicrobial activity of a novel chitosan Schiff bases based on heterocyclic moieties. 61
32112843 2020
Biogenic Silver and Zero-Valent Iron Nanoparticles by Feijoa: Biosynthesis, Characterization, Cytotoxic, Antibacterial and Antioxidant Activities. 61
32560617 2020
Beta galactosidase mediated bio-enzymatically synthesized nano-gold with aggrandized cytotoxic potential against pathogenic bacteria and cancer cells. 61
32559647 2020
Floral extracts-mediated green synthesis of NiO nanoparticles and their diverse pharmacological evaluations. 61
32567498 2020
Synthesis and Biological Evaluation of Three New Chitosan Schiff Base Derivatives. 61
32566861 2020
A Prediction Tool for the Presence of Ceftriaxone-Resistant Uropathogens upon Hospital Admission. 61
32531880 2020
The Bactericidal Potential of LLDPE with Tio2/ZnO Nanocomposites Against Multidrug Resistant Pathogens Associated with Hospital Acquired Infections. 61
32498665 2020
Innate effector systems in primary human macrophages sensitize multidrug resistant Klebsiella pneumoniae to antibiotics. 61
32513857 2020
Graphitic carbon nitride: a sustainable photocatalyst for organic pollutant degradation and antibacterial applications. 61
32519096 2020
Incidence of and risk factors for surgical site infection after colorectal surgery: a multiple-center prospective study of 3,663 consecutive patients in China. 61
32505873 2020
A novel extended prophylactic antibiotic regimen in preterm pre-labor rupture of membranes: A randomized trial. 61
32407901 2020
The inhibitory effect of trisodium citrate on biofilms formed by Klebsiella pneumoniae. 61
32387258 2020
High-Throughput 16S rRNA Gene Sequencing of Butter Microbiota Reveals a Variety of Opportunistic Pathogens. 61
32397488 2020
Photocatalytic dye degradation and antimicrobial activities of Pure and Ag-doped ZnO using Cannabis sativa leaf extract. 61
32398650 2020
The expression of β-Defensin-2, IL-22, IL-22R1 and IL-10R2 in rat model of Klebsiella pneumonia and their correlation with histological grades. 61
32169023 2020
Disease burden and molecular epidemiology of carbapenem-resistant Klebsiella pneumonia infection in a tertiary hospital in China. 61
32566631 2020
A unusual case of multifocal pyogenic abscess formation following ERCP procedure. 61
32375832 2020
Engineering CRISPR interference system to enhance the production of pyrroloquinoline quinone in Klebsiella pneumonia. 61
32394472 2020
Infections in Pediatric Burn Patients: An Analysis of One Hundred Eighty-One Patients. 61
31589562 2020
Characterization of a multidrug-resistant Klebsiella pneumoniae ST3330 clone responsible for a nosocomial outbreak in a neonatal intensive care unit. 61
32434364 2020
Circulating fibrocytes traffic to the lung in murine acute lung injury and predict outcomes in human acute respiratory distress syndrome: a pilot study. 61
32460694 2020
[A single center study on antimicrobial use and bacterial resistance in burn ward]. 61
32392991 2020
SERS-based immunocapture and detection of pathogenic bacteria using a boronic acid-functionalized polydopamine-coated Au@Ag nanoprobe. 61
32342176 2020
Evaluation of subgingival microbiota around single tooth implants. 61
32489818 2020
Biocompatible Gels of Chitosan-Buriti Oil for Potential Wound Healing Applications. 61
32340366 2020
Silver nanoparticles synthesis using Wedelia urticifolia (Blume) DC. flower extract: Characterization and antibacterial activity evaluation. 61
32306505 2020
Klebsiella pneumoniae presents antimicrobial drug resistance for β-lactam through the ESBL/PBP signaling pathway. 61
32256721 2020
Functional characterization of a broad and potent neutralizing monoclonal antibody directed against outer membrane protein (OMP) of Salmonella typhimurium. 61
31997109 2020
Characterization of phenazine-1-carboxylic acid by Klebsiella sp. NP-C49 from the coral environment in Gulf of Kutch, India. 61
31667534 2020
Validation of Camel's Fetal Fluids as Antimicrobial Agents. 61
32185466 2020
First Report of Extended-Spectrum Betalactamase-Producing Klebsiella pneumoniae Among Fecal Carriage in Iran: High Diversity of Clonal Relatedness and Virulence Factor Profiles. 61
30277830 2020
Bacteriological Profile and Antibiotic Resistance in patients with Urinary tract infection in Tertiary care teaching Hospital in western Rajasthan India. 61
32188395 2020
Lymphocyte-To-Monocyte Ratio as the Best Simple Predictor of Bacterial Infection in Patients with Liver Cirrhosis. 61
32155772 2020
Antibacterial activity of the crude extracts from medicinally important Thuja occidentalis. 61
32276908 2020
Spontaneous Pneumothorax After Rupture of the Cavity as the Initial Presentation of Tuberculosis in the Emergency Department. 61
32193366 2020
Bacterial pathogens from lower respiratory tract infections: A study from Western Rajasthan. 61
32509624 2020
Synthesis and Design of Norfloxacin drug delivery system based on PLA/TiO2 nanocomposites: Antibacterial and antitumor activities. 61
31923987 2020
Polymyxin for the treatment of intracranial infections of extensively drug-resistant bacteria in children after neurosurgical operation. 61
32193830 2020
Allograft hemorrhage as a manifestation of carbapenem-resistant Klebsiella pneumonia infection in kidney transplant recipients: Case series. 61
32221060 2020

Variations for Klebsiella Pneumonia

Expression for Klebsiella Pneumonia

Search GEO for disease gene expression data for Klebsiella Pneumonia.

Pathways for Klebsiella Pneumonia

Pathways related to Klebsiella Pneumonia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
11.3 IL17RA IL17F IL17A
Show member pathways
11.26 IL17RA IL17F IL17B IL17A
Show member pathways
11.09 IL17RA IL17F IL17A

GO Terms for Klebsiella Pneumonia

Cellular components related to Klebsiella Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 PLAT IL17F IL17B IL17A CRP CRHBP
2 extracellular region GO:0005576 9.32 PLAT MUCL1 IL17RA IL17F IL17B IL17A

Biological processes related to Klebsiella Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.5 IL17F IL17B IL17A CRP CRHBP CD40LG
2 interleukin-17-mediated signaling pathway GO:0097400 9.33 IL17RA IL17F IL17A
3 positive regulation of interleukin-23 production GO:0032747 9.32 IL17RA IL17A
4 fibroblast activation GO:0072537 9.26 IL17RA IL17A
5 positive regulation of cytokine production involved in inflammatory response GO:1900017 8.92 IL17RA IL17F IL17B IL17A

Molecular functions related to Klebsiella Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IL17F IL17B IL17A CD40LG

Sources for Klebsiella Pneumonia

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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