MCID: KLB003
MIFTS: 36

Klebsiella Pneumonia

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Klebsiella Pneumonia

Summaries for Klebsiella Pneumonia

Disease Ontology : 12 A bacterial pneumonia involving Klebsiella pneumoniae infection. Patients with Klebsiella pneumonia tend to cough up a characteristic sputum that is said to resemble "red-currant jelly". Klebsiella pneumonia tends to affect people with underlying diseases, such as alcoholism, diabetes and chronic lung disease. The symptoms include high fever, rigors and pleuritic pain, and hemoptysis.

MalaCards based summary : Klebsiella Pneumonia, also known as pneumonia due to klebsiella pneumoniae, is related to klebsiella infection and 48,xyyy. An important gene associated with Klebsiella Pneumonia is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways is Selenium Micronutrient Network. The drugs Ciprofloxacin and Ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and colon.

Wikipedia : 75 Klebsiella pneumoniae is a Gram-negative, non-motile, encapsulated, lactose-fermenting, facultative... more...

Related Diseases for Klebsiella Pneumonia

Diseases related to Klebsiella Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 356)
# Related Disease Score Top Affiliating Genes
1 klebsiella infection 11.8
2 48,xyyy 11.0
3 pneumonia 11.0
4 acute cystitis 10.9
5 endophthalmitis 10.9
6 meningitis 10.8
7 toxic shock syndrome 10.8
8 bacterial infectious disease 10.8
9 inflammatory spondylopathy 10.7
10 spondylitis 10.7
11 spondyloarthropathy 1 10.7
12 peritonitis 10.7
13 osteomyelitis 10.6
14 neutropenia 10.6
15 mastitis 10.6
16 bacterial pneumonia 10.6
17 endocarditis 10.6
18 fasciitis 10.6
19 necrotizing fasciitis 10.5
20 diarrhea 10.5
21 47,xyy 10.5
22 cystitis 10.5
23 septic arthritis 10.5
24 bacteriuria 10.5
25 bacterial meningitis 10.5
26 alcohol dependence 10.4
27 helix syndrome 10.4
28 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.4
29 pyelonephritis 10.4
30 liver cirrhosis 10.4
31 haemophilus influenzae 10.4
32 bacteremia 2 10.4
33 lung abscess 10.4
34 rare surgical neurologic disease 10.4
35 respiratory failure 10.4
36 cellulitis 10.4
37 arthritis 10.4
38 epidural abscess 10.3
39 bronchopneumonia 10.3
40 acute kidney failure 10.3
41 thrombophlebitis 10.3
42 spinal cord injury 10.3
43 enterocolitis 10.3
44 disseminated intravascular coagulation 10.3
45 uveitis 10.3
46 gastroenteritis 10.3
47 pyomyositis 10.3
48 anterior uveitis 10.3
49 cytokine deficiency 10.3
50 back pain 10.3

Graphical network of the top 20 diseases related to Klebsiella Pneumonia:



Diseases related to Klebsiella Pneumonia

Symptoms & Phenotypes for Klebsiella Pneumonia

Drugs & Therapeutics for Klebsiella Pneumonia

Drugs for Klebsiella Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
2
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
3
Tazobactam Approved Phase 4 89786-04-9 123630
4
Piperacillin Approved Phase 4 66258-76-2 43672
5
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
6
leucovorin Approved Phase 4 58-05-9 143 6006
7
Sulfamethoxazole Approved Phase 4 723-46-6 5329
8
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
9
Meropenem Approved, Investigational Phase 4 119478-56-7, 96036-03-2 64778 441130
10
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
11 Topoisomerase Inhibitors Phase 4
12 Antitubercular Agents Phase 4
13 Liver Extracts Phase 4
14 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
15 Anti-Bacterial Agents Phase 4
16 Anti-Infective Agents Phase 4
17 Pharmaceutical Solutions Phase 4
18 Piperacillin, Tazobactam Drug Combination Phase 4
19 beta-Lactamase Inhibitors Phase 4
20 Folic Acid Antagonists Phase 4
21 Cytochrome P-450 Enzyme Inhibitors Phase 4
22 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
23 Renal Agents Phase 4
24 Folate Phase 4
25 Vitamin B Complex Phase 4
26 Vitamin B9 Phase 4
27 Antiparasitic Agents Phase 4
28 Anti-Infective Agents, Urinary Phase 4
29 Antiprotozoal Agents Phase 4
30 Antimalarials Phase 4
31 Anti-Retroviral Agents Phase 4
32 Sitafloxacin Experimental, Investigational Phase 2, Phase 3 163253-35-8
33 Fluoroquinolones Phase 2, Phase 3
34 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
35
Cefdinir Approved Phase 2 91832-40-5 6915944
36
Cefixime Approved, Investigational Phase 2 79350-37-1 54362 5362065
37
Cephalexin Approved, Investigational, Vet_approved Phase 2 15686-71-2 27447
38 Antibiotics, Antitubercular Phase 2
39
Colistin Approved 1264-72-8, 1066-17-7 5311054
40
Vancomycin Approved 1404-90-6 441141 14969
41
Neomycin Approved, Vet_approved 1404-04-2 8378
42
Streptomycin Approved, Vet_approved 57-92-1 19649
43 Gentamicins
44 Polymyxins

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 SELECTIVE DIGESTIVE DECONTAMINATION USING ORAL GENTAMICIN AND ORAL POLYMYXIN E FOR ERADICATION OF CARBAPENEM-RESISTANT KLEBSIELLA PNEUMONIAE CARRIAGE IN HOSPITALIZED PATIENTS Unknown status NCT01761487 Phase 4
2 Use Of High Dose Colistin in Multi Drug Resistant Gram Negative Infections in Critically Ill Adult Patients. Randomized Controlled Clinical Trial Unknown status NCT02162966 Phase 4 High Dose Colistin;Standard Dose Colistin
3 A Multi-centre Randomised Open-label Active Comparator-controlled Non-inferiority Trial Comparing Oral to Intravenous Antibiotics in the Early Management of Klebsiella Pneumoniae Liver Abscess Completed NCT01723150 Phase 4 Ciprofloxacin;Ceftriaxone;Trimethoprim/sulfamethoxazole;Ertapenem
4 Piperacillin/Tazobactam Versus Carbapenems in Non-bacteremic Urinary Tract Infections Due to Extended-spectrum β-lactamase (ESBL)-Producing Escherichia Coli or Klebsiella Pneumoniae - (CAPITIS Study) Recruiting NCT03891433 Phase 4 Meropenem;Ertapenem 1000 MG;Piperacillin, Tazobactam 4-0.5G Solution for Injection
5 Randomized Clinical Trial to Assess Whether the Duration of Cotrimoxazole Preventive Therapy in HIV Patients With CD4 Counts >350 CD4 Cells/µL by Antiretroviral Treatment Influences the Rate of Carriage of Multidrug-resistant Bacteria Recruiting NCT03087890 Phase 4 Cotrimoxazole;Placebo
6 Sitafloxacin and Ertapenem Treatment for Acute Urinary Tract Infection Caused by E. Coli or K. Pneumoniae in Post-kidney Transplantation Patients Recruiting NCT02729116 Phase 2, Phase 3 Sitafloxacin;Ertapenem
7 Safety and Efficacy Study of Eradication of Carbapenem Resistant Klebsiella Pneumonia From the Gastrointestinal Tract by Probiotics. Unknown status NCT00722410 Phase 1, Phase 2 Polyethylene glycol
8 Targeted Clinical Trials to Reduce the Risk of Antimicrobial Resistance The SCOUT Study: "Short Course Therapy for Urinary Tract Infections in Children" Active, not recruiting NCT01595529 Phase 2 Cefixime;Cephalexin;Trimethoprim/Sulfamethoxazole
9 The Impact of Targeted Therapy on Microorganism in Patients With Psoriasis Unknown status NCT01504113
10 A Randomized Open Label Study Evaluating the Role of Oral Antibiotics in an Aim to Eradicate Carrier State of Carbapenem- Resistant Klebsiella Pneumonia (KPC). Completed NCT01266499 Colistin (Polymyxin E) 100mg x 4/d;both medications;will not receive PO treatment;PO Garamycin 80mg x 4/d
11 The Incidence of Extended-spectrum β-lactamase (ESBL) Klebsiella Pneumonia in Patient on Renal Replacement Therapy Completed NCT01612182
12 Turkish Prospective Cohort Study on Carbapenem Resistant Klebsiella Pneumonia Bacteremia: a National Multicenter Observational Study Completed NCT03597841 Combination therapy
13 Double Carbapenem as Rescue Strategy for the Treatment of Severe Carbapenemase-Producing Klebsiella Pneumoniae Infections: A Two-Center Matched Case-Control Study Completed NCT03094494
14 Antibiotic Intervention Trial in a Medical Intensive Care Unit to Reduce the Acquisition of Vancomycin-Resistant Enterococci and ESBL Producing Escherichia Coli and Klebsiella Pneumoniae. Completed NCT00167986 vancomycin-resistant enterococci and ESBL
15 Detecting Infections Rapidly and Easily for Bacteremia Trial (DIREBT)-Part I (Prospective Collection and Freezing of Whole Blood Specimens) Completed NCT01919762
16 Effects of Piperacillin-Tazobactam Use on the Prevalence Rate of Extended-Spectrum Beta-Lactamase (ESBL) Producing Escherichia Coli and Klebsiella Pneumoniae in Hematology and Oncology Units. Completed NCT00167999 piperacillin-tazobactam
17 Efficacy of Intestinal Decontamination in Patients Colonized by Carbapenem-resistant Klebsiella Pneumoniae and Colistin Completed NCT02604849 Neomycin;Streptomycin;Gentamicins
18 Risk Factors for Quinolone Resistance Among Extended-Spectrum Beta-Lactamase-Producing Klebsiella Species Completed NCT00518661
19 Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features Completed NCT01139112
20 Prospective Observational Study, Impact of Plasma Levels of Colistin in Patients With Carbapenem Resistant Acinetobacter Baumannii Infection Completed NCT02482961 colistimethate sodium
21 Community - Associated Extended-spectrum Beta-lactamases (ESBL) Completed NCT00363220
22 Sites of Colonization in Hospitalized Patients With Infections Caused by Extended-Spectrum Beta-Lactamase Producing Escherichia Coli and Klebsiella Pneumoniae Completed NCT01324726
23 Exploratory Study on the Ocular Surface Microbiome and Correlation to Clinical Parameters Completed NCT02161341
24 Klebsiella Pneumoniae Infection in China: Epidemiology, Molecular Characteristics, Treatment, and Outcome Recruiting NCT03598543
25 Bacterial Transmission Surveillance in Neonatal Intensive Care Unit: Transmission Dynamics and Drug Resistance Patterns Active, not recruiting NCT02401204
26 Oral and Tracheal Cultures in Pediatric ICU Patients Compared to Healthy Children Not yet recruiting NCT03418272
27 Epidemiological Characteristics and Treatment Protocol for Carbapenem-Resistant Klebsiella Pneumoniae in China Not yet recruiting NCT03245632

Search NIH Clinical Center for Klebsiella Pneumonia

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Tetracycline

Cochrane evidence based reviews: klebsiella infections

Genetic Tests for Klebsiella Pneumonia

Anatomical Context for Klebsiella Pneumonia

MalaCards organs/tissues related to Klebsiella Pneumonia:

41
Lung, Liver, Colon, Kidney, Prostate, Neutrophil, Bone

Publications for Klebsiella Pneumonia

Articles related to Klebsiella Pneumonia:

(show top 50) (show all 1020)
# Title Authors PMID Year
1
Nosocomial bloodstream infections in a pediatric intensive care unit: 3-year survey. 9 38
17534230 2007
2
Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases. 9 38
15206050 2004
3
An expeditious and environmentally benign synthesis of dispiro-3-phenylpyrrolothiazoles in ACI/EG eutectic mixture and its antioxidant and antimicrobial activities against urinary tract pathogens. 38
31384790 2019
4
Synthesis of silver nanoparticles (AgNPs) from leaf extract of Salvia miltiorrhiza and its anticancer potential in human prostate cancer LNCaP cell lines. 38
31299869 2019
5
An indole diterpenoid isolated from the fungus Drechmeria sp. and its antimicrobial activity. 38
30221546 2019
6
Single mutidrug resistant enterobacteriacae donor-derived infection in four solid organ transplant recipients: a case report. 38
31412850 2019
7
Copper Oxide Nanomaterials Derived from Zanthoxylum armatum DC. and Berberis lycium Royle Plant Species: Characterization, Assessment of Free Radical Scavenging and Antibacterial Activity. 38
31207044 2019
8
Aflatoxin B1 removal by three bacterial strains and optimization of fermentation process parameters. 38
31433514 2019
9
Septic Meningitis and Liver Abscess due to Hypermucoviscous Klebsiella pneumoniae Complicated with Chronic Strongyloidiasis in a Human T-lymphotropic Virus 1 Carrier. 38
31434825 2019
10
Nutritive value of treated Quercus infectoria and Quercus libani leaves with the tannin-degrading bacterium Klebsiella pneumoniae for ruminant feeding in vitro. 38
31386790 2019
11
Molecular investigation of two novel bacteriophages of a facultative methylotroph, Raoultella ornithinolytica: first report of Raoultella phages. 38
31111257 2019
12
Degradable antimicrobial polycarbonates with unexpected activity and selectivity for treating multidrug-resistant Klebsiella pneumoniae lung infection in mice. 38
31129359 2019
13
Plasmacytoid dendritic cell depletion modifies FoxP3+ T cell homeostasis and the clinical course of bacterial pneumonia in mice. 38
31265764 2019
14
Rare Earth Element (REE) Nd3+ Doped CeO₂ Nanoparticles Using Aloe vera Leaf Extract: Structural, Optical and Antimicrobial Activity. 38
30764957 2019
15
Phenotypic Resistance in Photodynamic Inactivation Unravelled at the Single Bacterium Level. 38
31286765 2019
16
Characterisation of plant growth-promoting rhizobacteria from rhizosphere soil of heat-stressed and unstressed wheat and their use as bio-inoculant. 38
30734452 2019
17
The treatment of nosocomial meningitis and brain abscess by carbapenem-resistant Klebsiella pneumonia. 38
31342790 2019
18
Interactive antimicrobial and toxicity profiles of Pittosporum angustifolium Lodd. extracts with conventional antimicrobials. 38
31000372 2019
19
Alkaloids from the root of Indonesian Annona muricata L. 38
31282747 2019
20
Sterilization performance comparison between an autosampler-ready microporous filter vial and a syringe-based filter. 38
31356842 2019
21
Regulation of NF-κB/MAPK signaling pathway attenuates the acute lung inflammation in Klebsiella pneumonia rats by mollugin treatment. 38
31075430 2019
22
Corrigendum to: 1757. Using the Desirability of Outcome Ranking for Management of Antimicrobial Therapy (DOOR-MAT) to Assess Antibiotic Therapy Guided by Rapid Molecular Diagnostics (RMD) in Bloodstream Infection (BSI) Caused by Escherichia coli and Klebsiella pneumonia. 38
31290855 2019
23
An Outbreak of KPC-Producing Klebsiella pneumoniae Linked with an Index Case of Community-Acquired KPC-Producing Isolate: Epidemiological Investigation and Whole Genome Sequencing Analysis. 38
31334673 2019
24
l-Proline protects mice challenged by Klebsiella pneumoniae bacteremia. 38
31324551 2019
25
Susceptibility pattern of tracheal tube isolates from Intensive Care Unit of Fauji Foundation Hospital Rawalpindi. 38
31308567 2019
26
[Impact of antimicrobial stewardship program on antimicrobial usage and detection rate of multidrug-resistant gram-negative bacteria]. 38
31269557 2019
27
Investigation of plasmid mediated AmpC beta-lactamases in Escherichia coli and Klebsiella pneumoniae isolates by phenotypic and genotypic. 38
31189291 2019
28
Integration of two pKPX-2 derived antibiotic resistance islands in the genome of an ESBL-producing Klebsiella pneumonia ST3483 from Lebanon. 38
31202976 2019
29
Changes in Gene Expression in Human Epithelial and Mast Cells in Response to Vesicles from Klebsiella pneumonia ATCC 13883. 38
31031441 2019
30
Polymyxin B clinical outcomes: A prospective study of patients undergoing intravenous treatment. 38
30666679 2019
31
Plasma treated fabrics coated with naturally derived Ag-NPs for biomedical application. 38
31171740 2019
32
Point prevalence surveys of health-care-associated infections: a systematic review. 38
31215326 2019
33
Proteomics-based discrimination of differentially expressed proteins in antibiotic-sensitive and antibiotic-resistant Salmonella Typhimurium, Klebsiella pneumoniae, and Staphylococcus aureus. 38
31240342 2019
34
The role of urbanization in soil and groundwater contamination by heavy metals and pathogenic bacteria: A case study from Oman. 38
31193711 2019
35
Biosynthesis of Ag and Cu NPs by secondary metabolites of usnic acid and thymol with biological macromolecules aggregation and antibacterial activities against multi drug resistant (MDR) bacteria. 38
30708006 2019
36
Microbiological Pattern of Surgical Site Infection Following Caesarean Section at the University of Calabar Teaching Hospital. 38
31198449 2019
37
Comparison Study of Different Extracts of Plectranthus madagascariensis, P. neochilus and the Rare P. porcatus (Lamiaceae): Chemical Characterization, Antioxidant, Antimicrobial and Cytotoxic Activities. 38
31072074 2019
38
A Case of a Large Sub-retinal Abscess Secondary to Klebsiella pneumoniae Endophthalmitis in a Pyelonephritis Patient. 38
31316877 2019
39
Rapid, Visual Detection of Klebsiella pneumoniae Using Magnetic Nanoparticles and an Horseradish Peroxidase-Probe Based Immunosensor. 38
30890236 2019
40
Proteome profiling of carbapenem-resistant K. pneumoniae clinical isolate (NDM-4): Exploring the mechanism of resistance and potential drug targets. 38
30953729 2019
41
Community profiling of the intestinal microbial community of juvenile Hammerhead Sharks (Sphyrna lewini) from the Rewa Delta, Fiji. 38
31073209 2019
42
IMPACT OF AG NANOPARTICLES ON MICROORGANISMS, CAUSATIVE AGENTS OF PURULENT-INFLAMMATORY PROCESSES. 38
31215896 2019
43
Novel Diazenyl Containing Phenyl Styryl Ketone Derivatives as Antimicrobial Agents. 38
31328083 2019
44
Extended spectrum beta-lactamase-producing Klebsiella pneumoniae outbreak reveals incubators as pathogen reservoir in neonatal care center. 38
30671695 2019
45
Study the antibacterial and antibiofilm activity of Carum copticum against antibiotic-resistant bacteria in planktonic and biofilm forms. 38
30731188 2019
46
Carbapenem resistant organisms: A 9-year surveillance and trends at Saint George University Medical Center. 38
30956158 2019
47
Antimicrobial spectrum activity of bacteriocinogenic Staphylococcus strains isolated from goat and sheep milk. 38
30799112 2019
48
An evaluation of multidrug-resistant (MDR) bacteria in patients with urinary stone disease: data from a high-volume stone management center. 38
31025083 2019
49
A comparative analysis of infection in patients with malignant cancer: A clinical pharmacist consultation study. 38
31003836 2019
50
Assessment of antioxidant, antibacterial and anti-proliferative (lung cancer cell line A549) activities of green synthesized silver nanoparticles from Derris trifoliata. 38
30997029 2019

Variations for Klebsiella Pneumonia

Expression for Klebsiella Pneumonia

Search GEO for disease gene expression data for Klebsiella Pneumonia.

Pathways for Klebsiella Pneumonia

Pathways related to Klebsiella Pneumonia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.96 PLAT MAT1A

GO Terms for Klebsiella Pneumonia

Sources for Klebsiella Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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