MCID: KLN004
MIFTS: 5

Kleiner Holmes Syndrome

Categories: Rare diseases

Aliases & Classifications for Kleiner Holmes Syndrome

MalaCards integrated aliases for Kleiner Holmes Syndrome:

Name: Kleiner Holmes Syndrome 53 72
Hallux Varus and Preaxial Polysyndactyly 53

Classifications:



External Ids:

UMLS 72 C1856197

Summaries for Kleiner Holmes Syndrome

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 2110DefinitionHallux varus-preaxial polysyndactyly syndrome is a rare, genetic, congenital limb malformation disorder characterized by bilateral medial displacement of the hallux and preaxial polysyndactyly of the first toes. Radiographs show broad, shortened, misshapen first metatarsals and may associate incomplete or complete duplication of proximal phalanges and duplication or triplication of distal phalanges. There have been no further descriptions in the literature since 1980.Visit the Orphanet disease page for more resources.

MalaCards based summary : Kleiner Holmes Syndrome, also known as hallux varus and preaxial polysyndactyly, is related to hallux varus and preaxial polysyndactyly.

Related Diseases for Kleiner Holmes Syndrome

Diseases related to Kleiner Holmes Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hallux varus and preaxial polysyndactyly 11.7

Symptoms & Phenotypes for Kleiner Holmes Syndrome

Drugs & Therapeutics for Kleiner Holmes Syndrome

Search Clinical Trials , NIH Clinical Center for Kleiner Holmes Syndrome

Genetic Tests for Kleiner Holmes Syndrome

Anatomical Context for Kleiner Holmes Syndrome

Publications for Kleiner Holmes Syndrome

Articles related to Kleiner Holmes Syndrome:

# Title Authors PMID Year
1
Brief clinical report: hallux varus and preaxial polysyndactyly in brothers. 38
6255798 1980

Variations for Kleiner Holmes Syndrome

Expression for Kleiner Holmes Syndrome

Search GEO for disease gene expression data for Kleiner Holmes Syndrome.

Pathways for Kleiner Holmes Syndrome

GO Terms for Kleiner Holmes Syndrome

Sources for Kleiner Holmes Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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