MCID: KLM001
MIFTS: 13

Klumpke Paralysis

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Klumpke Paralysis

MalaCards integrated aliases for Klumpke Paralysis:

Name: Klumpke Paralysis 52 71
Dejerine-Klumpke Palsy 52 53
Lower Brachial Plexus Palsy 52
Klumpke's Palsy 52

Classifications:



External Ids:

ICD10 32 P14.1
UMLS 71 C0270898

Summaries for Klumpke Paralysis

NIH Rare Diseases : 52 Klumpke paralysis is a rare type of birth injury to the nerves around a newborn's shoulder, known as the brachial plexus . Most types of brachial plexus injuries affect the shoulder and upper arm. Klumpke paralysis affects the movement of the lower arm and hand. Signs and symptoms include weakness and loss of movement of the lower arm and hand. Some babies experience drooping of the eyelid on the opposite side of the face as well. This symptom may also be referred to as Horner syndrome . Klumpke paralysis is caused by an injury to the nerves of the brachial plexus that which may result during birth due to a a difficult delivery. This injury can cause a stretch injury (neuropraxia), scarring, or tearing of the brachial plexus nerves. Tearing is called an "avulsion" when the tear is at the spine, and "rupture" when it is not. Diagnosis of Klumpke paralysis is made at birth by physical examination. Sometimes x-rays and other tests are done to determine the extent of the nerve damage. Most infants with Klumpke paralysis have the more mild form of injury (neuropraxia) and often recover within 6 months. Some infants will require surgery. Rarely, infants with Klumpke paralysis will have some permanent damage.

MalaCards based summary : Klumpke Paralysis, also known as dejerine-klumpke palsy, is related to erb-duchenne and dejerine-klumpke palsies and brachial plexus lesion. Affiliated tissues include testes.

NINDS : 53 The brachial plexus is a network of nerves that conducts signals from the spine to the shoulder, arm, and hand. Brachial plexus injuries are caused by damage to those nerves. Erb-Duchenne (Erb's) palsy refers to paralysis of the upper brachial plexus. Dejerine-Klumpke (Klumpke's) palsy refers to paralysis of the lower brachial plexus. Although injuries can occur at any time, many brachial plexus injuries happen when a baby's shoulders become impacted during delivery and the brachial plexus nerves stretch or tear. There are four types of brachial plexus injuries: avulsion, the most severe type, in which the nerve is torn from the spine; rupture, in which the nerve is torn but not at the spinal attachment; neuroma, in which the nerve has torn and healed but scar tissue puts pressure on the injured nerve and prevents it from conducting signals to the muscles; and neuropraxia or stretch, in which the nerve has been damaged but not torn. Neuropraxia is the most common type of brachial plexus injury. Symptoms of brachial plexus injury may include a limp or paralyzed arm; lack of muscle control in the arm, hand, or wrist; and lack of feeling or sensation in the arm or hand.

Wikipedia : 74 Klumpke's paralysis is a variety of partial palsy of the lower roots of the brachial plexus. The... more...

Related Diseases for Klumpke Paralysis

Diseases related to Klumpke Paralysis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 erb-duchenne and dejerine-klumpke palsies 12.7
2 brachial plexus lesion 10.3
3 neuritis 10.2

Symptoms & Phenotypes for Klumpke Paralysis

Drugs & Therapeutics for Klumpke Paralysis

Search Clinical Trials , NIH Clinical Center for Klumpke Paralysis

Genetic Tests for Klumpke Paralysis

Anatomical Context for Klumpke Paralysis

MalaCards organs/tissues related to Klumpke Paralysis:

40
Testes

Publications for Klumpke Paralysis

Articles related to Klumpke Paralysis:

# Title Authors PMID Year
1
Obstetrical Brachial Plexus Palsy. 52
28709767 2017
2
Evaluation and management of brachial plexus birth palsy. 52
24684916 2014
3
Obstetrical brachial plexus palsy: electrodiagnostical study and functional outcome. 61
21313897 2010
4
Neurotization with the brachialis muscle motor nerve. 61
16685741 2006
5
[Amipaque myeloradiculography in the diagnosis of brachial plexus root rupture]. 61
7245981 1981
6
Traumatic Neuritis of Inner Cord (Klumpke-paralysis); Prefixed Type of Plexus. 61
19975243 1911

Variations for Klumpke Paralysis

Expression for Klumpke Paralysis

Search GEO for disease gene expression data for Klumpke Paralysis.

Pathways for Klumpke Paralysis

GO Terms for Klumpke Paralysis

Sources for Klumpke Paralysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....