Kohler's Disease

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GARD: ¹⁹ Kohler disease is a condition that affects a bone at the arch of the foot called the tarsal navicular bone. X-rays show that this bone is initially compressed and later breaks into pieces before healing and hardening back into bone. Signs and symptoms of the condition include swelling, redness and/or tenderness of the affected foot which can lead to a limp or abnormal gait (style of walking). Although the exact underlying cause of Kohler disease is unknown, some scientists suspect that it may be caused by excessive strain on the tarsal navicular bone and its associated blood vessels before the bone is completely ossified (hardened).

MalaCards based summary: Kohler's Disease, also known as kohler disease, is related to osteochondrosis and avascular necrosis. An important gene associated with Kohler's Disease is COL11A2 (Collagen Type XI Alpha 2 Chain), and among its related pathways/superpathways are Extracellular matrix organization and MET promotes cell motility. Affiliated tissues include navicular bone of foot and bone, and related phenotypes are pedal edema and chondritis

Orphanet: ⁵⁸ A rare bone disease characterized by avascular necrosis of the navicular bone in children. Patients present with sudden unexplained foot pain, inability to bear weight, and limping. Radiographic features include flattening, fragmentation, and patchy sclerosis of the navicular bone. Soft tissue swelling may be associated. The condition is most commonly unilateral and self-limiting. Boys are more often affected than girls.

Disease Ontology: ¹¹ An osteochondrosis that results in death and collapse located in navicular bone of foot.

Wikipedia: ⁷⁵ Köhler disease (also spelled "Kohler" and referred to in some texts as Kohler disease I) is a rare bone... more...

Search Clinical Trials, NIH Clinical Center for Kohler's Disease