Kohler's Disease

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Disease Ontology 12 DOID:11760 ICD9CM 34 732.5 SNOMED-CT 67 203392007

Orphanet 58 ORPHA563991 UMLS 71 C0022765 C0158444 C0264096

NIH Rare Diseases : ⁵² Kohler disease is a condition that affects a bone at the arch of the foot called the tarsal navicular bone. X-rays show that this bone is initially compressed and later breaks into pieces before healing and hardening back into bone. It occurs most frequently in children between the ages of 5 and 10 years. Signs and symptoms of the condition include swelling, redness and/or tenderness of the affected foot which can lead to a limp or abnormal gait (style of walking). Although the exact underlying cause of Kohler disease is unknown, some scientists suspect that it may be caused by excessive strain on the tarsal navicular bone and its associated blood vessels before the bone is completely ossified (hardened). The condition typically resolves on its own with or without treatment; however, pain relievers, rest, avoidance of weight-bearing activities, and/or casting may be recommended to help manage symptoms.

MalaCards based summary : Kohler's Disease, also known as kohler disease, is related to osteochondrosis and achilles bursitis. An important gene associated with Kohler's Disease is PDLIM2 (PDZ And LIM Domain 2), and among its related pathways/superpathways is G-protein signaling_Rap2B regulation pathway. Affiliated tissues include navicular bone of foot and bone, and related phenotypes are craniofacial and hearing/vestibular/ear

Disease Ontology : ¹² An osteochondrosis that results in death and collapse located in navicular bone of foot.

Wikipedia : ⁷⁴ Köhler disease (also spelled "Kohler" and referred to in some texts as Kohler disease I) is a rare bone... more...

Search Clinical Trials , NIH Clinical Center for Kohler's Disease

Search GEO for disease gene expression data for Kohler's Disease.