MCID: KRN001
MIFTS: 44

Korean Hemorrhagic Fever

Categories: Infectious diseases, Nephrological diseases

Aliases & Classifications for Korean Hemorrhagic Fever

MalaCards integrated aliases for Korean Hemorrhagic Fever:

Name: Korean Hemorrhagic Fever 12 15
Hemorrhagic Fever with Renal Syndrome 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050200
UMLS 73 C0019101

Summaries for Korean Hemorrhagic Fever

Disease Ontology : 12 A hemorrhagic fever with renal syndrome that results in infection located in kidney, has material basis in Hantaan virus, which is transmitted by the eurasian field mouse, Apodemus agrarius, or has material basis in Seoul virus, which is transmitted by norwegian rat, Rattus norvegicus. The infection has symptom headache, has symptom back pain, has symptom abdominal pain, has symptom fever, has symptom chills, has symptom nausea, has symptom blurred vision, has symptom flushing of the face, has symptom redness of the eyes, has symptom rash, has symptom low blood pressure, has symptom acute shock, has symptom vascular leakage, and has symptom acute kidney failure, which can cause severe fluid overload.

MalaCards based summary : Korean Hemorrhagic Fever, also known as hemorrhagic fever with renal syndrome, is related to hemorrhagic fever and disseminated intravascular coagulation, and has symptoms including fever, abdominal pain and back pain. An important gene associated with Korean Hemorrhagic Fever is NDUFA6 (NADH:Ubiquinone Oxidoreductase Subunit A6), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). The drugs Antibodies, Blocking and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include kidney, kidney and eye, and related phenotype is cardiovascular system.

Related Diseases for Korean Hemorrhagic Fever

Diseases related to Korean Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 hemorrhagic fever 31.0 F2 F3 SERPINC1
2 disseminated intravascular coagulation 29.9 F2 F3 SERPINC1 SERPINF2
3 hemorrhagic fever with renal syndrome 11.6
4 cold urticaria 10.2 SERPINC1 SERPINF2
5 heparin-induced thrombocytopenia 10.2 F3 SERPINC1
6 retinal artery occlusion 10.2 F2 SERPINC1
7 conjugate gaze palsy 10.2 F3 PLG
8 mitral valve stenosis 10.2 NPPA SERPINC1
9 factor xiii deficiency 10.2 F3 SERPINF2
10 acute cor pulmonale 10.2 PLG SERPINF2
11 spinal cord infarction 10.2 F2 SERPINC1
12 prothrombin deficiency, congenital 10.2 F2 SERPINC1
13 prothrombin deficiency 10.2 F2 F3
14 acute pulmonary heart disease 10.2 PLG SERPINF2
15 ischemic colitis 10.2 F2 SERPINC1
16 cerebral sinovenous thrombosis 10.2 F2 F3
17 sneddon syndrome 10.2 F2 SERPINC1
18 dysbaric osteonecrosis 10.2 F3 PLG
19 alcohol-related birth defect 10.2 F2 F3
20 hantavirus pulmonary syndrome 10.2 F2 F3
21 esophageal varix 10.2 F2 SERPINC1
22 vascular hemostatic disease 10.2 F2 F3
23 vertebral artery occlusion 10.2 F3 PLG
24 splenic disease 10.1 F2 F3
25 cerebral arteritis 10.1 PLG VWF
26 gastroschisis 10.1 F2 NPPA
27 antithrombin iii deficiency 10.1 F2 SERPINC1
28 active peptic ulcer disease 10.1 F2 VWF
29 osteosclerotic myeloma 10.1 PLG VWF
30 factor xii deficiency 10.1 F3 SERPINC1
31 acute poststreptococcal glomerulonephritis 10.1 NPPA PLG SERPINF2
32 brachydactyly, type d 10.1 F2 VWF
33 post-thrombotic syndrome 10.1 F2 SERPINC1
34 hypersplenism 10.1 F2 SERPINC1
35 lemierre's syndrome 10.1 F3 PLG
36 factor viii deficiency 10.1 F2 VWF
37 central retinal vein occlusion 10.1 F2 SERPINC1
38 thrombophlebitis 10.1 F2 SERPINC1 SERPINF2
39 subendocardial myocardial infarction 10.1 F2 LDHA SERPINC1
40 hepatorenal syndrome 10.1 F2 NPPA
41 platelet aggregation, spontaneous 10.1 SERPINC1 SERPINF2 VWF
42 fournier gangrene 10.1 F2 F3 SERPINC1
43 hepatic veno-occlusive disease 10.1 F3 PLG SERPINC1
44 sagittal sinus thrombosis 10.1 F2 F3 SERPINC1
45 hepatic infarction 10.1 F2 F3 SERPINC1
46 peripheral vertigo 10.1 F2 F3 SERPINC1
47 blood protein disease 10.1 F2 F3 SERPINC1
48 branch retinal artery occlusion 10.1 F2 F3 SERPINC1
49 grange syndrome 10.1 F3 VWF
50 pulmonary immaturity 10.1 F3 SERPINC1

Graphical network of the top 20 diseases related to Korean Hemorrhagic Fever:



Diseases related to Korean Hemorrhagic Fever

Symptoms & Phenotypes for Korean Hemorrhagic Fever

Symptoms:

12 (show all 14)
  • fever
  • abdominal pain
  • back pain
  • blurred vision
  • headache
  • nausea
  • chills
  • low blood pressure
  • rash
  • flushing of the face
  • redness of the eyes
  • acute shock
  • vascular leakage
  • acute kidney failure

MGI Mouse Phenotypes related to Korean Hemorrhagic Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.28 ADCY10 F2 F3 LDHA NPPA PLG

Drugs & Therapeutics for Korean Hemorrhagic Fever

Drugs for Korean Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies, Blocking Phase 3
2 Antibodies Phase 3
3 Vaccines Phase 3,Phase 2,Phase 1
4 Immunoglobulins Phase 3
5
Racepinephrine Approved Phase 2,Phase 1 329-65-7 838
6
Epinephrine Approved, Vet_approved Phase 2,Phase 1 51-43-4 5816
7
Ribavirin Approved Phase 2 36791-04-5 37542
8 Immunologic Factors Phase 2,Phase 1
9 Epinephryl borate Phase 2,Phase 1
10 Antiviral Agents Phase 2
11 Antimetabolites Phase 2
12 Anti-Infective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRS Completed NCT02360514 Phase 3 Hantavax injection
2 Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever Active, not recruiting NCT02116205 Phase 2
3 Ribavirin for Hemorrhagic Fever With Renal Syndrome Enrolling by invitation NCT00623168 Phase 2 Ribavirin
4 Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany Withdrawn NCT00868946 Phase 2 Virazole (Ribavirin)
5 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines Completed NCT01502345 Phase 1
6 Diagnostic of Puumala Virus Infection in France Recruiting NCT02455375

Search NIH Clinical Center for Korean Hemorrhagic Fever

Genetic Tests for Korean Hemorrhagic Fever

Anatomical Context for Korean Hemorrhagic Fever

The Foundational Model of Anatomy Ontology organs/tissues related to Korean Hemorrhagic Fever:

19
Kidney

MalaCards organs/tissues related to Korean Hemorrhagic Fever:

41
Kidney, Eye, Testes, Liver, Heart, Spinal Cord, Monocytes

Publications for Korean Hemorrhagic Fever

Articles related to Korean Hemorrhagic Fever:

(show top 50) (show all 66)
# Title Authors Year
1
Risk of Venous Thromboembolism Following Hemorrhagic Fever With Renal Syndrome: A Self-controlled Case Series Study. ( 29020303 )
2018
2
Expression of CD206 and CD163 on intermediate CD14++CD16+ monocytes are increased in hemorrhagic fever with renal syndrome and are correlated with disease severity. ( 29857122 )
2018
3
Platelet Distribution Width at First Day of Hospital Admission in Patients with Hemorrhagic Fever with Renal Syndrome Caused by Hantaan Virus May Predict Disease Severity and Critical Patients' Survival. ( 30018676 )
2018
4
Spatiotemporal analysis and forecasting model of hemorrhagic fever with renal syndrome in mainland China. ( 30078384 )
2018
5
Two cases of imported hemorrhagic fever with renal syndrome and systematic review of literature. ( 30114480 )
2018
6
Spatiotemporal patterns of hemorrhagic fever with renal syndrome in Hebei Province, China, 2001-2016. ( 30133872 )
2018
7
Environmental Determinants of Hemorrhagic Fever with Renal Syndrome in High-Risk Counties in China: A Time Series Analysis (2002-2012). ( 30226151 )
2018
8
There is Still Seasonal Variation of Hemorrhagic Fever with Renal Syndrome in Gyeonggi Province. ( 30270589 )
2018
9
Neutrophil Activation in Acute Hemorrhagic Fever With Renal Syndrome Is Mediated by Hantavirus-Infected Microvascular Endothelial Cells. ( 30283445 )
2018
10
Spatial heterogeneity of hemorrhagic fever with renal syndrome is driven by environmental factors and rodent community composition. ( 30356291 )
2018
11
A new Seasonal Difference Space-Time Autoregressive Integrated Moving Average (SD-STARIMA) model and spatiotemporal trend prediction analysis for Hemorrhagic Fever with Renal Syndrome (HFRS). ( 30475830 )
2018
12
The impact of the vaccination program for hemorrhagic fever with renal syndrome in Hu County, China. ( 24252696 )
2014
13
Bilateral Simultaneous Angle-closure Glaucoma Associated With Septic Condition of Korean Hemorrhagic Fever (KHF). ( 23429623 )
2013
14
Hemorrhagic fever with renal syndrome and coexisting hantavirus pulmonary syndrome. ( 26889418 )
2012
15
A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for hemorrhagic fever with renal syndrome. ( 22248821 )
2012
16
Isolation and characterization of hantaviruses in Far East Russia and etiology of hemorrhagic fever with renal syndrome in the region. ( 22403334 )
2012
17
Determination of urine tumor necrosis factor, IL-6, IL-8, and serum IL-6 in patients with hemorrhagic fever with renal syndrome. ( 23141988 )
2012
18
Evidence of disseminated intravascular coagulation in a hemorrhagic fever with renal syndrome-scoring models and severe illness. ( 21731657 )
2011
19
Epidemiological study on hemorrhagic fever with renal syndrome in flood areas. ( 21464543 )
2011
20
Hemorrhagic fever with renal syndrome in 4 US soldiers, South Korea, 2005. ( 19891878 )
2009
21
Dobrava virus RNA load in patients who have hemorrhagic fever with renal syndrome. ( 18269319 )
2008
22
Hemorrhagic fever with renal syndrome (HFRS, Korean hemorrhagic fever). ( 16983539 )
2007
23
Isolation of the etiologic agent of Korean hemorrhagic fever. 1978. ( 15517702 )
2004
24
Puumala and Dobrava hantaviruses causing hemorrhagic fever with renal syndrome in Estonia. ( 11205639 )
2000
25
Nucleotide sequence of nucleocapsid protein (N) of Hantaan virus isolated from a Korean hemorrhagic fever patient. ( 9524814 )
1997
26
Magnetic resonance imaging of the kidney in hemorrhagic fever with renal syndrome: its histopathologic correlation. ( 9274847 )
1997
27
Localization of Hantaan viral envelope glycoproteins by monoclonal antibodies in renal tissues from patients with Korean hemorrhagic fever H. ( 7692720 )
1993
28
Application of a recombinant baculovirus expressing hantavirus nucleocapsid protein as a diagnostic antigen in IFA test: cross reactivities among 3 serotypes of hantavirus which causes hemorrhagic fever with renal syndrome (HFRS). ( 7906956 )
1993
29
Korean hemorrhagic fever: nursing care critical to recovery. ( 1673232 )
1991
30
Clinical studies on hemorrhagic fever with renal syndrome found in Nagoya City University Medical School. ( 1685205 )
1991
31
Korean hemorrhagic fever: environmental health and medical surveillance measures. ( 1980148 )
1990
32
Plasma concentration of atrial natriuretic peptide in different phases of Korean hemorrhagic fever. ( 2563575 )
1989
33
Coagulopathy in hemorrhagic fever with renal syndrome (Korean hemorrhagic fever). ( 2568677 )
1989
34
Experimental labyrinthitis in rats caused by infecting with virus causing hemorrhagic fever with renal syndrome (HFRS). ( 2504018 )
1989
35
Comparison of virulence between two strains of Rattus serotype hemorrhagic fever with renal syndrome (HFRS) virus in newborn rats. ( 2566896 )
1989
36
Leads from the MMWR. Korean hemorrhagic fever. ( 2893844 )
1988
37
Korean hemorrhagic fever. ( 2893250 )
1988
38
Early ocular manifestations of Korean hemorrhagic fever. ( 2907359 )
1988
39
An explanation of renal hemodynamics in acute renal failure based on sequential CT in patients with Korean hemorrhagic fever. ( 2883204 )
1987
40
Effects of human and murine interferons against hemorrhagic fever with renal syndrome (HFRS) virus (Hantaan virus). ( 2451468 )
1987
41
Early diagnosis of hemorrhagic fever with renal syndrome by IgM ELISA technique. ( 2888601 )
1987
42
Clinical and epidemiological aspects of hemorrhagic fever with renal syndrome (HFRS) in Greece. ( 2888688 )
1987
43
Procoagulant activity and thrombelastography in Korean hemorrhagic fever. ( 2908802 )
1986
44
Detection of hemagglutination-inhibiting antibodies in patients with nephropathia epidemica and Korean hemorrhagic fever by using Puumala virus cell culture antigen. ( 2871114 )
1986
45
Korean hemorrhagic fever: case report and observation on successful resuscitation of a patient with renal failure. ( 2873528 )
1986
46
Unique selective right atrial hemorrhage with epidemic (Korean) hemorrhagic fever. ( 6147078 )
1984
47
An immune adherence assay for discrimination between etiologic agents of hemorrhagic fever with renal syndrome. ( 6141206 )
1984
48
Hemorrhagic fever with renal syndrome--France. ( 6143248 )
1984
49
Disseminated intravascular coagulation in Korean hemorrhagic fever. ( 6141786 )
1983
50
Epidemic hemorrhagic fever with renal syndrome. A broadening horizon. ( 6139987 )
1983

Variations for Korean Hemorrhagic Fever

Expression for Korean Hemorrhagic Fever

Search GEO for disease gene expression data for Korean Hemorrhagic Fever.

Pathways for Korean Hemorrhagic Fever

GO Terms for Korean Hemorrhagic Fever

Cellular components related to Korean Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.87 F2 LDHA LDHC PLG SERPINC1 SERPINF2
2 extracellular region GO:0005576 9.86 F2 F3 NPPA PLG PRNT SERPINC1
3 platelet alpha granule lumen GO:0031093 9.33 PLG SERPINF2 VWF
4 blood microparticle GO:0072562 9.26 F2 PLG SERPINC1 SERPINF2
5 collagen-containing extracellular matrix GO:0062023 9.1 F3 NPPA PLG SERPINC1 SERPINF2 VWF

Biological processes related to Korean Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.62 F2 NPPA PLG SERPINC1
2 platelet degranulation GO:0002576 9.58 PLG SERPINF2 VWF
3 blood coagulation GO:0007596 9.55 F2 F3 PLG SERPINC1 VWF
4 positive regulation of collagen biosynthetic process GO:0032967 9.49 F2 SERPINF2
5 pyruvate metabolic process GO:0006090 9.48 LDHA LDHC
6 carboxylic acid metabolic process GO:0019752 9.46 LDHA LDHC
7 blood coagulation, intrinsic pathway GO:0007597 9.43 F2 VWF
8 fibrinolysis GO:0042730 9.43 F2 PLG SERPINF2
9 regulation of blood coagulation GO:0030193 9.37 F2 SERPINC1
10 negative regulation of fibrinolysis GO:0051918 9.13 F2 PLG SERPINF2
11 hemostasis GO:0007599 9.02 F2 F3 PLG SERPINC1 VWF

Molecular functions related to Korean Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 LDHA LDHC
2 L-lactate dehydrogenase activity GO:0004459 8.96 LDHA LDHC
3 protease binding GO:0002020 8.92 F3 SERPINC1 SERPINF2 VWF

Sources for Korean Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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