MCID: KRN001
MIFTS: 46

Korean Hemorrhagic Fever

Categories: Infectious diseases, Nephrological diseases

Aliases & Classifications for Korean Hemorrhagic Fever

MalaCards integrated aliases for Korean Hemorrhagic Fever:

Name: Korean Hemorrhagic Fever 12 15
Hemorrhagic Fever with Renal Syndrome 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050200
UMLS 74 C0019101

Summaries for Korean Hemorrhagic Fever

Disease Ontology : 12 A hemorrhagic fever with renal syndrome that results in infection located in kidney, has material basis in Hantaan virus, which is transmitted by the eurasian field mouse, Apodemus agrarius, or has material basis in Seoul virus, which is transmitted by norwegian rat, Rattus norvegicus. The infection has symptom headache, has symptom back pain, has symptom abdominal pain, has symptom fever, has symptom chills, has symptom nausea, has symptom blurred vision, has symptom flushing of the face, has symptom redness of the eyes, has symptom rash, has symptom low blood pressure, has symptom acute shock, has symptom vascular leakage, and has symptom acute kidney failure, which can cause severe fluid overload.

MalaCards based summary : Korean Hemorrhagic Fever, also known as hemorrhagic fever with renal syndrome, is related to disseminated intravascular coagulation and hemorrhagic fever with renal syndrome, and has symptoms including fever, abdominal pain and back pain. An important gene associated with Korean Hemorrhagic Fever is ADCY10 (Adenylate Cyclase 10), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). The drugs Antibodies, Blocking and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include kidney, kidney and eye, and related phenotype is cardiovascular system.

Related Diseases for Korean Hemorrhagic Fever

Diseases related to Korean Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 disseminated intravascular coagulation 30.0 F2 F3 SERPINC1 SERPINF2
2 hemorrhagic fever with renal syndrome 11.7
3 cold urticaria 10.4 SERPINC1 SERPINF2
4 heparin-induced thrombocytopenia 10.3 F3 SERPINC1
5 retinal artery occlusion 10.3 F2 SERPINC1
6 conjugate gaze palsy 10.3 F3 PLG
7 spinal cord infarction 10.3 F2 SERPINC1
8 prothrombin deficiency, congenital 10.3 F2 SERPINC1
9 prothrombin deficiency 10.3 F2 F3
10 acute cor pulmonale 10.3 PLG SERPINF2
11 cerebral sinovenous thrombosis 10.3 F2 F3
12 mitral valve stenosis 10.3 NPPA SERPINC1
13 ischemic colitis 10.3 F2 SERPINC1
14 factor xiii deficiency 10.3 F3 SERPINF2
15 sneddon syndrome 10.3 F2 SERPINC1
16 alcohol-related birth defect 10.3 F2 F3
17 hantavirus pulmonary syndrome 10.3 F2 F3
18 dysbaric osteonecrosis 10.3 F3 PLG
19 acute pulmonary heart disease 10.3 PLG SERPINF2
20 cerebral arteritis 10.3 PLG VWF
21 vascular hemostatic disease 10.3 F2 F3
22 esophageal varix 10.3 F2 SERPINC1
23 splenic disease 10.2 F2 F3
24 vertebral artery occlusion 10.2 F3 PLG
25 active peptic ulcer disease 10.2 F2 VWF
26 brachydactyly, type d 10.2 F2 VWF
27 osteosclerotic myeloma 10.2 PLG VWF
28 acute poststreptococcal glomerulonephritis 10.2 NPPA PLG SERPINF2
29 antithrombin iii deficiency 10.2 F2 SERPINC1
30 factor viii deficiency 10.2 F2 VWF
31 post-thrombotic syndrome 10.2 F2 SERPINC1
32 thrombophlebitis 10.2 F2 SERPINC1 SERPINF2
33 subendocardial myocardial infarction 10.2 F2 LDHA SERPINC1
34 hypersplenism 10.2 F2 SERPINC1
35 platelet aggregation, spontaneous 10.2 SERPINC1 SERPINF2 VWF
36 phototoxic dermatitis 10.2 LDHA LDHC
37 fournier gangrene 10.2 F2 F3 SERPINC1
38 lemierre's syndrome 10.2 F3 PLG
39 sagittal sinus thrombosis 10.2 F2 F3 SERPINC1
40 hepatic veno-occlusive disease 10.2 F3 PLG SERPINC1
41 non-gestational choriocarcinoma 10.2 LDHA LDHC
42 hepatic infarction 10.2 F2 F3 SERPINC1
43 peripheral vertigo 10.2 F2 F3 SERPINC1
44 blood protein disease 10.2 F2 F3 SERPINC1
45 branch retinal artery occlusion 10.1 F2 F3 SERPINC1
46 cerebral falx meningioma 10.1 F2 F3 PLG
47 factor xi deficiency 10.1 F2 F3 SERPINC1
48 zika fever 10.1 F3 NDUFA6 PRNT
49 protein s deficiency 10.1 F2 F3 SERPINC1
50 hemophilia b 10.1 F2 F3 SERPINC1

Graphical network of the top 20 diseases related to Korean Hemorrhagic Fever:



Diseases related to Korean Hemorrhagic Fever

Symptoms & Phenotypes for Korean Hemorrhagic Fever

Symptoms:

12 (show all 14)
  • fever
  • abdominal pain
  • back pain
  • headache
  • blurred vision
  • nausea
  • chills
  • low blood pressure
  • rash
  • flushing of the face
  • redness of the eyes
  • acute shock
  • vascular leakage
  • acute kidney failure

MGI Mouse Phenotypes related to Korean Hemorrhagic Fever:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.28 ADCY10 F2 F3 LDHA NPPA PLG

Drugs & Therapeutics for Korean Hemorrhagic Fever

Drugs for Korean Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies, Blocking Phase 3
2 Antibodies Phase 3
3 Immunoglobulins Phase 3
4 Vaccines Phase 3,Phase 2,Phase 1
5
Epinephrine Approved, Vet_approved Phase 2,Phase 1 51-43-4 5816
6
Racepinephrine Approved Phase 2,Phase 1 329-65-7 838
7
Ribavirin Approved Phase 2 36791-04-5 37542
8 Immunologic Factors Phase 2,Phase 1
9 Epinephryl borate Phase 2,Phase 1
10 Antiviral Agents Phase 2
11 Anti-Infective Agents Phase 2
12 Antimetabolites Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRS Completed NCT02360514 Phase 3 Hantavax injection
2 Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever Active, not recruiting NCT02116205 Phase 2
3 Ribavirin for Hemorrhagic Fever With Renal Syndrome Enrolling by invitation NCT00623168 Phase 2 Ribavirin
4 Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany Withdrawn NCT00868946 Phase 2 Virazole (Ribavirin)
5 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines Completed NCT01502345 Phase 1
6 Diagnostic of Puumala Virus Infection in France Recruiting NCT02455375

Search NIH Clinical Center for Korean Hemorrhagic Fever

Genetic Tests for Korean Hemorrhagic Fever

Anatomical Context for Korean Hemorrhagic Fever

The Foundational Model of Anatomy Ontology organs/tissues related to Korean Hemorrhagic Fever:

20
Kidney

MalaCards organs/tissues related to Korean Hemorrhagic Fever:

42
Kidney, Eye, T Cells, Heart, Testes, Endothelial, B Cells

Publications for Korean Hemorrhagic Fever

Articles related to Korean Hemorrhagic Fever:

(show top 50) (show all 443)
# Title Authors Year
1
Hemorrhagic Fever with Renal Syndrome as a Cause of Acute Diarrhea. ( 30915955 )
2019
2
Two cases of imported hemorrhagic fever with renal syndrome and systematic review of literature. ( 30114480 )
2019
3
Spatiotemporal patterns of hemorrhagic fever with renal syndrome in Hebei Province, China, 2001-2016. ( 30133872 )
2019
4
Dentin matrix protein 1 correlates with the severity of hemorrhagic fever with renal syndrome and promotes hyper-permeability of endothelial cells infected by Hantaan virus. ( 30735719 )
2019
5
Epidemiologic study on changes in occurrence of hemorrhagic fever with renal syndrome in Republic of Korea for 17 years according to age group: 2001-2017. ( 30760218 )
2019
6
Effects of climate factors on hemorrhagic fever with renal syndrome in Changchun, 2013 to 2017. ( 30817583 )
2019
7
Recent Increase of Human Granulocytic Anaplasmosis and Co-Infection with Scrub Typhus or Korean Hemorrhagic Fever with Renal Syndrome in Korea. ( 30914905 )
2019
8
Severe fever with thrombocytopenia syndrome can masquerade as hemorrhagic fever with renal syndrome. ( 30925154 )
2019
9
Three asymptomatic animal infection models of hemorrhagic fever with renal syndrome caused by hantaviruses. ( 31075144 )
2019
10
The characteristics of current natural foci of hemorrhagic fever with renal syndrome in Shandong Province, China, 2012-2015. ( 31107874 )
2019
11
Hemorrhagic fever with renal syndrome accompanied by panhypopituitarism and central diabetes insipidus: a case report. ( 29508304 )
2018
12
Guillain-Barre syndrome associated with hemorrhagic fever with renal syndrome in China: a case report. ( 29587642 )
2018
13
Risk of Venous Thromboembolism Following Hemorrhagic Fever With Renal Syndrome: A Self-controlled Case Series Study. ( 29020303 )
2018
14
Delayed Interferon Type 1-Induced Antiviral State Is a Potential Factor for Hemorrhagic Fever With Renal Syndrome Severity. ( 29281106 )
2018
15
Landscape and rodent community composition are associated with risk of hemorrhagic fever with renal syndrome in two cities in China, 2006-2013. ( 29329512 )
2018
16
Mapping the epidemic changes and risks of hemorrhagic fever with renal syndrome in Shaanxi Province, China, 2005-2016. ( 29335595 )
2018
17
Protective Effectiveness of Inactivated Hantavirus Vaccine Against Hemorrhagic Fever With Renal Syndrome. ( 29373686 )
2018
18
Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome. ( 29450213 )
2018
19
Involvement of CD8+ T cells in the development of renal hemorrhage in a mouse model of hemorrhagic fever with renal syndrome. ( 29488118 )
2018
20
Study on expression of plasma sCD138 in patients with hemorrhagic fever with renal syndrome. ( 29490629 )
2018
21
A Nonfatal Case of Dobrava Hantavirus Hemorrhagic Fever with Renal Syndrome Combined with Hantavirus Cardiopulmonary Syndrome. ( 29563720 )
2018
22
Author Correction: Mapping the epidemic changes and risks of hemorrhagic fever with renal syndrome in Shaanxi Province, China, 2005-2016. ( 29651028 )
2018
23
Relationship between circulating vascular endothelial growth factor and its soluble receptor in patients with hemorrhagic fever with renal syndrome. ( 29765019 )
2018
24
Sequential assessment of clinical and laboratory parameters in patients with hemorrhagic fever with renal syndrome. ( 29791494 )
2018
25
Expression of CD206 and CD163 on intermediate CD14++CD16+ monocytes are increased in hemorrhagic fever with renal syndrome and are correlated with disease severity. ( 29857122 )
2018
26
High Serum Procalcitonin Concentrations in Patients With Hemorrhagic Fever With Renal Syndrome Caused by Hantaan Virus. ( 29868489 )
2018
27
Impact of meteorological factors on hemorrhagic fever with renal syndrome in 19 cities in China, 2005-2014. ( 29913587 )
2018
28
Meteorological factors and risk of hemorrhagic fever with renal syndrome in Guangzhou, southern China, 2006-2015. ( 29949572 )
2018
29
Absence of a Seasonal Variation of Hemorrhagic Fever with Renal Syndrome in Yeoncheon Compared to Nationwide Korea. ( 29968979 )
2018
30
Platelet Distribution Width at First Day of Hospital Admission in Patients with Hemorrhagic Fever with Renal Syndrome Caused by Hantaan Virus May Predict Disease Severity and Critical Patients' Survival. ( 30018676 )
2018
31
Spatiotemporal analysis and forecasting model of hemorrhagic fever with renal syndrome in mainland China. ( 30078384 )
2018
32
Environmental Determinants of Hemorrhagic Fever with Renal Syndrome in High-Risk Counties in China: A Time Series Analysis (2002-2012). ( 30226151 )
2018
33
There is Still Seasonal Variation of Hemorrhagic Fever with Renal Syndrome in Gyeonggi Province. ( 30270589 )
2018
34
Neutrophil Activation in Acute Hemorrhagic Fever With Renal Syndrome Is Mediated by Hantavirus-Infected Microvascular Endothelial Cells. ( 30283445 )
2018
35
Spatial heterogeneity of hemorrhagic fever with renal syndrome is driven by environmental factors and rodent community composition. ( 30356291 )
2018
36
A new Seasonal Difference Space-Time Autoregressive Integrated Moving Average (SD-STARIMA) model and spatiotemporal trend prediction analysis for Hemorrhagic Fever with Renal Syndrome (HFRS). ( 30475830 )
2018
37
Effectiveness of inactivated hantavirus vaccine on the disease severity of hemorrhagic fever with renal syndrome. ( 30619692 )
2018
38
Hemorrhagic fever with renal syndrome (HFRS) in Poland ( 30810003 )
2018
39
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome. ( 28572804 )
2017
40
The assessment of Hantaan virus-specific antibody responses after the immunization program for hemorrhagic fever with renal syndrome in northwest China. ( 27824286 )
2017
41
Cytokine response to Hantaan virus infection in patients with hemorrhagic fever with renal syndrome. ( 27943332 )
2017
42
Anthropogenically driven environmental changes shift the ecological dynamics of hemorrhagic fever with renal syndrome. ( 28141833 )
2017
43
Lack of association between integrin αvβ3 gene polymorphisms and hemorrhagic fever with renal syndrome in Han Chinese from Hubei, China. ( 28190175 )
2017
44
Hantavirus retinitis and concurrent hemorrhagic fever with renal syndrome. ( 28237172 )
2017
45
Hemorrhagic fever with renal syndrome in Albania. Focus on predictors of acute kidney injury in HFRS. ( 28411480 )
2017
46
Hemorrhagic fever with renal syndrome caused by Hantaan virus infection in four pregnant Chinese women. ( 28504470 )
2017
47
The influence of climatic factors on the development of hemorrhagic fever with renal syndrome and leptospirosis during the peak season in Korea: an ecologic study. ( 28592316 )
2017
48
Analysis of hemorrhagic fever with renal syndrome and its pathogenic gene sequence based on geographic information system. ( 28685549 )
2017
49
Performance assessment of the SAPS II and SOFA scoring systems in Hanta virus Hemorrhagic Fever with Renal Syndrome. ( 28804005 )
2017
50
Meteorological factors affect the epidemiology of hemorrhagic fever with renal syndrome via altering the breeding and hantavirus-carrying states of rodents and mites: a 9 years' longitudinal study. ( 29184158 )
2017

Variations for Korean Hemorrhagic Fever

Expression for Korean Hemorrhagic Fever

Search GEO for disease gene expression data for Korean Hemorrhagic Fever.

Pathways for Korean Hemorrhagic Fever

GO Terms for Korean Hemorrhagic Fever

Cellular components related to Korean Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.87 F2 LDHA LDHC PLG SERPINC1 SERPINF2
2 extracellular region GO:0005576 9.86 F2 F3 NPPA PLG PRNT SERPINC1
3 platelet alpha granule lumen GO:0031093 9.33 PLG SERPINF2 VWF
4 blood microparticle GO:0072562 9.26 F2 PLG SERPINC1 SERPINF2
5 collagen-containing extracellular matrix GO:0062023 9.1 F3 NPPA PLG SERPINC1 SERPINF2 VWF

Biological processes related to Korean Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.62 F2 NPPA PLG SERPINC1
2 platelet degranulation GO:0002576 9.61 PLG SERPINF2 VWF
3 blood coagulation GO:0007596 9.55 F2 F3 PLG SERPINC1 VWF
4 positive regulation of collagen biosynthetic process GO:0032967 9.49 F2 SERPINF2
5 pyruvate metabolic process GO:0006090 9.48 LDHA LDHC
6 carboxylic acid metabolic process GO:0019752 9.46 LDHA LDHC
7 fibrinolysis GO:0042730 9.43 F2 PLG SERPINF2
8 blood coagulation, intrinsic pathway GO:0007597 9.4 F2 VWF
9 regulation of blood coagulation GO:0030193 9.37 F2 SERPINC1
10 negative regulation of fibrinolysis GO:0051918 9.13 F2 PLG SERPINF2
11 hemostasis GO:0007599 9.02 F2 F3 PLG SERPINC1 VWF

Molecular functions related to Korean Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 LDHA LDHC
2 L-lactate dehydrogenase activity GO:0004459 8.96 LDHA LDHC
3 protease binding GO:0002020 8.92 F3 SERPINC1 SERPINF2 VWF

Sources for Korean Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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