MCID: KRN001
MIFTS: 43

Korean Hemorrhagic Fever

Categories: Infectious diseases, Nephrological diseases

Aliases & Classifications for Korean Hemorrhagic Fever

MalaCards integrated aliases for Korean Hemorrhagic Fever:

Name: Korean Hemorrhagic Fever 12 15
Hemorrhagic Fever with Renal Syndrome 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050200
UMLS 74 C0019101

Summaries for Korean Hemorrhagic Fever

Disease Ontology : 12 A hemorrhagic fever with renal syndrome that results in infection located in kidney, has material basis in Hantaan virus, which is transmitted by the eurasian field mouse, Apodemus agrarius, or has material basis in Seoul virus, which is transmitted by norwegian rat, Rattus norvegicus. The infection has symptom headache, has symptom back pain, has symptom abdominal pain, has symptom fever, has symptom chills, has symptom nausea, has symptom blurred vision, has symptom flushing of the face, has symptom redness of the eyes, has symptom rash, has symptom low blood pressure, has symptom acute shock, has symptom vascular leakage, and has symptom acute kidney failure, which can cause severe fluid overload.

MalaCards based summary : Korean Hemorrhagic Fever, also known as hemorrhagic fever with renal syndrome, is related to hemorrhagic fever and disseminated intravascular coagulation, and has symptoms including fever, abdominal pain and back pain. An important gene associated with Korean Hemorrhagic Fever is ADCY10 (Adenylate Cyclase 10), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). The drugs Antibodies, Blocking and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include kidney, kidney and eye, and related phenotype is cardiovascular system.

Related Diseases for Korean Hemorrhagic Fever

Diseases related to Korean Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 hemorrhagic fever 31.4 F2 SERPINC1
2 disseminated intravascular coagulation 30.0 F2 F3 SERPINC1 SERPINF2
3 hemorrhagic fever with renal syndrome 11.6
4 cold urticaria 10.4 SERPINC1 SERPINF2
5 heparin-induced thrombocytopenia 10.3 F3 SERPINC1
6 retinal artery occlusion 10.3 F2 SERPINC1
7 conjugate gaze palsy 10.3 F3 PLG
8 spinal cord infarction 10.3 F2 SERPINC1
9 prothrombin deficiency, congenital 10.3 F2 SERPINC1
10 prothrombin deficiency 10.3 F2 F3
11 acute cor pulmonale 10.3 PLG SERPINF2
12 cerebral sinovenous thrombosis 10.3 F2 F3
13 mitral valve stenosis 10.3 NPPA SERPINC1
14 ischemic colitis 10.3 F2 SERPINC1
15 factor xiii deficiency 10.3 F3 SERPINF2
16 sneddon syndrome 10.3 F2 SERPINC1
17 alcohol-related birth defect 10.3 F2 F3
18 hantavirus pulmonary syndrome 10.3 F2 F3
19 dysbaric osteonecrosis 10.3 F3 PLG
20 acute pulmonary heart disease 10.3 PLG SERPINF2
21 cerebral arteritis 10.3 PLG VWF
22 vascular hemostatic disease 10.3 F2 F3
23 esophageal varix 10.3 F2 SERPINC1
24 splenic disease 10.2 F2 F3
25 vertebral artery occlusion 10.2 F3 PLG
26 active peptic ulcer disease 10.2 F2 VWF
27 brachydactyly, type d 10.2 F2 VWF
28 osteosclerotic myeloma 10.2 PLG VWF
29 acute poststreptococcal glomerulonephritis 10.2 NPPA PLG SERPINF2
30 antithrombin iii deficiency 10.2 F2 SERPINC1
31 factor viii deficiency 10.2 F2 VWF
32 post-thrombotic syndrome 10.2 F2 SERPINC1
33 thrombophlebitis 10.2 F2 SERPINC1 SERPINF2
34 subendocardial myocardial infarction 10.2 F2 LDHA SERPINC1
35 hypersplenism 10.2 F2 SERPINC1
36 platelet aggregation, spontaneous 10.2 SERPINC1 SERPINF2 VWF
37 phototoxic dermatitis 10.2 LDHA LDHC
38 fournier gangrene 10.2 F2 F3 SERPINC1
39 lemierre's syndrome 10.2 F3 PLG
40 sagittal sinus thrombosis 10.2 F2 F3 SERPINC1
41 hepatic veno-occlusive disease 10.2 F3 PLG SERPINC1
42 non-gestational choriocarcinoma 10.2 LDHA LDHC
43 hepatic infarction 10.2 F2 F3 SERPINC1
44 peripheral vertigo 10.1 F2 F3 SERPINC1
45 blood protein disease 10.1 F2 F3 SERPINC1
46 branch retinal artery occlusion 10.1 F2 F3 SERPINC1
47 cerebral falx meningioma 10.1 F2 F3 PLG
48 factor xi deficiency 10.1 F2 F3 SERPINC1
49 zika fever 10.1 F3 NDUFA6 PRNT
50 protein s deficiency 10.1 F2 F3 SERPINC1

Graphical network of the top 20 diseases related to Korean Hemorrhagic Fever:



Diseases related to Korean Hemorrhagic Fever

Symptoms & Phenotypes for Korean Hemorrhagic Fever

Symptoms:

12 (show all 14)
  • fever
  • abdominal pain
  • back pain
  • blurred vision
  • headache
  • nausea
  • chills
  • low blood pressure
  • rash
  • flushing of the face
  • redness of the eyes
  • acute shock
  • vascular leakage
  • acute kidney failure

MGI Mouse Phenotypes related to Korean Hemorrhagic Fever:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.28 ADCY10 F2 F3 LDHA NPPA PLG

Drugs & Therapeutics for Korean Hemorrhagic Fever

Drugs for Korean Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies, Blocking Phase 3
2 Immunoglobulins Phase 3
3 Vaccines Phase 3,Phase 2,Phase 1
4 Antibodies Phase 3
5
Ribavirin Approved Phase 2 36791-04-5 37542
6
Epinephrine Approved, Vet_approved Phase 2,Phase 1 51-43-4 5816
7
Racepinephrine Approved Phase 2,Phase 1 329-65-7 838
8 Antimetabolites Phase 2
9 Anti-Infective Agents Phase 2
10 Antiviral Agents Phase 2
11 Epinephryl borate Phase 2,Phase 1
12 Immunologic Factors Phase 2,Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRS Completed NCT02360514 Phase 3 Hantavax injection
2 Ribavirin for Hemorrhagic Fever With Renal Syndrome Enrolling by invitation NCT00623168 Phase 2 Ribavirin
3 Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany Withdrawn NCT00868946 Phase 2 Virazole (Ribavirin)
4 Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever Active, not recruiting NCT02116205 Phase 2
5 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines Completed NCT01502345 Phase 1
6 Diagnostic of Puumala Virus Infection in France Recruiting NCT02455375

Search NIH Clinical Center for Korean Hemorrhagic Fever

Genetic Tests for Korean Hemorrhagic Fever

Anatomical Context for Korean Hemorrhagic Fever

The Foundational Model of Anatomy Ontology organs/tissues related to Korean Hemorrhagic Fever:

20
Kidney

MalaCards organs/tissues related to Korean Hemorrhagic Fever:

42
Kidney, Eye, Endothelial, Testes, Neutrophil

Publications for Korean Hemorrhagic Fever

Articles related to Korean Hemorrhagic Fever:

(show top 50) (show all 57)
# Title Authors Year
1
Hemorrhagic Fever with Renal Syndrome as a Cause of Acute Diarrhea. ( 30915955 )
2019
2
Dentin matrix protein 1 correlates with the severity of hemorrhagic fever with renal syndrome and promotes hyper-permeability of endothelial cells infected by Hantaan virus. ( 30735719 )
2019
3
Epidemiologic study on changes in occurrence of hemorrhagic fever with renal syndrome in Republic of Korea for 17 years according to age group: 2001-2017. ( 30760218 )
2019
4
Effects of climate factors on hemorrhagic fever with renal syndrome in Changchun, 2013 to 2017. ( 30817583 )
2019
5
Recent Increase of Human Granulocytic Anaplasmosis and Co-Infection with Scrub Typhus or Korean Hemorrhagic Fever with Renal Syndrome in Korea. ( 30914905 )
2019
6
Platelet Distribution Width at First Day of Hospital Admission in Patients with Hemorrhagic Fever with Renal Syndrome Caused by Hantaan Virus May Predict Disease Severity and Critical Patients' Survival. ( 30018676 )
2018
7
Spatiotemporal analysis and forecasting model of hemorrhagic fever with renal syndrome in mainland China. ( 30078384 )
2018
8
Two cases of imported hemorrhagic fever with renal syndrome and systematic review of literature. ( 30114480 )
2018
9
Spatiotemporal patterns of hemorrhagic fever with renal syndrome in Hebei Province, China, 2001-2016. ( 30133872 )
2018
10
Environmental Determinants of Hemorrhagic Fever with Renal Syndrome in High-Risk Counties in China: A Time Series Analysis (2002-2012). ( 30226151 )
2018
11
There is Still Seasonal Variation of Hemorrhagic Fever with Renal Syndrome in Gyeonggi Province. ( 30270589 )
2018
12
Neutrophil Activation in Acute Hemorrhagic Fever With Renal Syndrome Is Mediated by Hantavirus-Infected Microvascular Endothelial Cells. ( 30283445 )
2018
13
Spatial heterogeneity of hemorrhagic fever with renal syndrome is driven by environmental factors and rodent community composition. ( 30356291 )
2018
14
A new Seasonal Difference Space-Time Autoregressive Integrated Moving Average (SD-STARIMA) model and spatiotemporal trend prediction analysis for Hemorrhagic Fever with Renal Syndrome (HFRS). ( 30475830 )
2018
15
Effectiveness of inactivated hantavirus vaccine on the disease severity of hemorrhagic fever with renal syndrome. ( 30619692 )
2018
16
Hemorrhagic fever with renal syndrome (HFRS) in Poland ( 30810003 )
2018
17
[REVIEW OF EPIDEMIOLOGIC SITUATION ON HEMORRHAGIC FEVER WITH RENAL SYNDROME (HERS) IN RUSSIAN FEDERATION IN 1990 - 2015]. ( 30695531 )
2017
18
Bilateral Simultaneous Angle-closure Glaucoma Associated With Septic Condition of Korean Hemorrhagic Fever (KHF). ( 23429623 )
2013
19
Hemorrhagic fever with renal syndrome and coexisting hantavirus pulmonary syndrome. ( 26889418 )
2012
20
A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for hemorrhagic fever with renal syndrome. ( 22248821 )
2012
21
Dobrava virus RNA load in patients who have hemorrhagic fever with renal syndrome. ( 18269319 )
2008
22
Hemorrhagic fever with renal syndrome (HFRS, Korean hemorrhagic fever). ( 16983539 )
2007
23
Isolation of the etiologic agent of Korean hemorrhagic fever. 1978. ( 15517702 )
2004
24
Nucleotide sequence of nucleocapsid protein (N) of Hantaan virus isolated from a Korean hemorrhagic fever patient. ( 9524814 )
1997
25
Magnetic resonance imaging of the kidney in hemorrhagic fever with renal syndrome: its histopathologic correlation. ( 9274847 )
1997
26
Localization of Hantaan viral envelope glycoproteins by monoclonal antibodies in renal tissues from patients with Korean hemorrhagic fever H. ( 7692720 )
1993
27
Korean hemorrhagic fever: nursing care critical to recovery. ( 1673232 )
1991
28
Clinical studies on hemorrhagic fever with renal syndrome found in Nagoya City University Medical School. ( 1685205 )
1991
29
Korean hemorrhagic fever: environmental health and medical surveillance measures. ( 1980148 )
1990
30
Plasma concentration of atrial natriuretic peptide in different phases of Korean hemorrhagic fever. ( 2563575 )
1989
31
Coagulopathy in hemorrhagic fever with renal syndrome (Korean hemorrhagic fever). ( 2568677 )
1989
32
Leads from the MMWR. Korean hemorrhagic fever. ( 2893844 )
1988
33
Korean hemorrhagic fever. ( 2893250 )
1988
34
Early ocular manifestations of Korean hemorrhagic fever. ( 2907359 )
1988
35
An explanation of renal hemodynamics in acute renal failure based on sequential CT in patients with Korean hemorrhagic fever. ( 2883204 )
1987
36
Clinical and epidemiological aspects of hemorrhagic fever with renal syndrome (HFRS) in Greece. ( 2888688 )
1987
37
Procoagulant activity and thrombelastography in Korean hemorrhagic fever. ( 2908802 )
1986
38
Detection of hemagglutination-inhibiting antibodies in patients with nephropathia epidemica and Korean hemorrhagic fever by using Puumala virus cell culture antigen. ( 2871114 )
1986
39
Korean hemorrhagic fever: case report and observation on successful resuscitation of a patient with renal failure. ( 2873528 )
1986
40
Unique selective right atrial hemorrhage with epidemic (Korean) hemorrhagic fever. ( 6147078 )
1984
41
Disseminated intravascular coagulation in Korean hemorrhagic fever. ( 6141786 )
1983
42
Indirect immunofluorescence tests in Korean hemorrhagic fever and epidemic (endemic) nephropathia: treatment at low pH for removal of 'nonspecific' fluorescence in tissues from immunocompetent hosts. ( 6126464 )
1982
43
Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats. ( 6127366 )
1982
44
Korean hemorrhagic fever. ( 6124025 )
1982
45
Laboratory-acquired infections with Hantaan virus, the etiologic agent of Korean hemorrhagic fever. ( 6127367 )
1982
46
Korean hemorrhagic fever among rural residents in Japan. ( 6118386 )
1981
47
Propagation of Korean hemorrhagic fever virus in laboratory rats. ( 6111538 )
1981
48
Korean hemorrhagic fever: propagation of the etiologic agent in a cell line of human origin. ( 6110243 )
1981
49
Observations on natural and laboratory infection of rodents with the etiologic agent of Korean hemorrhagic fever. ( 6786119 )
1981
50
Intraspecific transmission of Hantaan virus, etiologic agent of Korean hemorrhagic fever, in the rodent Apodemus agrarius. ( 6116436 )
1981

Variations for Korean Hemorrhagic Fever

Expression for Korean Hemorrhagic Fever

Search GEO for disease gene expression data for Korean Hemorrhagic Fever.

Pathways for Korean Hemorrhagic Fever

GO Terms for Korean Hemorrhagic Fever

Cellular components related to Korean Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.87 F2 LDHA LDHC PLG SERPINC1 SERPINF2
2 extracellular region GO:0005576 9.86 F2 F3 NPPA PLG PRNT SERPINC1
3 platelet alpha granule lumen GO:0031093 9.33 PLG SERPINF2 VWF
4 blood microparticle GO:0072562 9.26 F2 PLG SERPINC1 SERPINF2
5 collagen-containing extracellular matrix GO:0062023 9.1 F3 NPPA PLG SERPINC1 SERPINF2 VWF

Biological processes related to Korean Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.62 F2 NPPA PLG SERPINC1
2 platelet degranulation GO:0002576 9.61 PLG SERPINF2 VWF
3 blood coagulation GO:0007596 9.55 F2 F3 PLG SERPINC1 VWF
4 positive regulation of collagen biosynthetic process GO:0032967 9.49 F2 SERPINF2
5 pyruvate metabolic process GO:0006090 9.48 LDHA LDHC
6 carboxylic acid metabolic process GO:0019752 9.46 LDHA LDHC
7 fibrinolysis GO:0042730 9.43 F2 PLG SERPINF2
8 blood coagulation, intrinsic pathway GO:0007597 9.4 F2 VWF
9 regulation of blood coagulation GO:0030193 9.37 F2 SERPINC1
10 negative regulation of fibrinolysis GO:0051918 9.13 F2 PLG SERPINF2
11 hemostasis GO:0007599 9.02 F2 F3 PLG SERPINC1 VWF

Molecular functions related to Korean Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 LDHA LDHC
2 L-lactate dehydrogenase activity GO:0004459 8.96 LDHA LDHC
3 protease binding GO:0002020 8.92 F3 SERPINC1 SERPINF2 VWF

Sources for Korean Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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