MCID: KRS005
MIFTS: 16

Korsakoff's Amnesic Syndrome

Categories: Neuronal diseases

Aliases & Classifications for Korsakoff's Amnesic Syndrome

MalaCards integrated aliases for Korsakoff's Amnesic Syndrome:

Name: Korsakoff's Amnesic Syndrome 55
Alcohol Induced Encephalopathy 74

Classifications:



External Ids:

UMLS 74 C2931917

Summaries for Korsakoff's Amnesic Syndrome

NINDS : 55 Wernicke's encephalopathy is a degenerative brain disorder caused by the lack of thiamine (vitamin B1). It may result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. B1 deficiency causes damage to the brain's thalamus and hypothalamus. Symptoms include mental confusion, vision problems, coma, hypothermia, low blood pressure, and lack of muscle coordination (ataxia). Korsakoff syndrome (also called Korsakoff's amnesic syndrome) is a memory disorder that results from vitamin B1 deficiency and is associated with alcoholism. Korsakoff's syndrome damages nerve cells and supporting cells in the brain and spinal cord, as well as the part of the brain involved with memory. Symptoms include amnesia, tremor, coma, disorientation, and vision problems, The disorder's main features are problems in acquiring new information or establishing new memories, and in retrieving previous memories. Although Wernicke's and Korsakoff's are related disorders, some scientists believe them to be different stages of the same disorder, which is called Wernicke-Korsakoff syndrome. Wernicke's encephalopathy represents the "acute" phase of the disorder and Korsakoff's amnesic syndrome represents the disorder progressing to a "chronic" or long-lasting stage.

MalaCards based summary : Korsakoff's Amnesic Syndrome, also known as alcohol induced encephalopathy, is related to wernicke-korsakoff syndrome and cerebral beriberi. The drugs Thiamine and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and hypothalamus.

Related Diseases for Korsakoff's Amnesic Syndrome

Diseases related to Korsakoff's Amnesic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 wernicke-korsakoff syndrome 11.6
2 cerebral beriberi 11.6
3 thrombosis 10.2
4 dementia 10.2
5 cavernous sinus thrombosis 10.2

Graphical network of the top 20 diseases related to Korsakoff's Amnesic Syndrome:



Diseases related to Korsakoff's Amnesic Syndrome

Symptoms & Phenotypes for Korsakoff's Amnesic Syndrome

Drugs & Therapeutics for Korsakoff's Amnesic Syndrome

Drugs for Korsakoff's Amnesic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 70-16-6, 59-43-8 1130
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
3 Vitamins Phase 4,Phase 2,Phase 3,Not Applicable
4 Thiamin Phase 4,Phase 2,Phase 3,Not Applicable
5 Micronutrients Phase 4,Phase 2,Phase 3
6 Vitamin B Complex Phase 4,Phase 2,Phase 3
7 Vitamin B9 Phase 4,Phase 2,Phase 3
8 Trace Elements Phase 4,Phase 2,Phase 3
9 Nutrients Phase 4,Phase 2,Phase 3
10 Folate Phase 4,Phase 2,Phase 3
11
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2, Phase 3 7487-88-9 24083
12
Ethanol Approved Phase 2, Phase 3 64-17-5 702
13
Histamine Approved, Investigational Phase 3 51-45-6 774
14
Promethazine Approved, Investigational Phase 3 60-87-7 4927
15
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
16
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
17 Anticonvulsants Phase 2, Phase 3
18 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
19 Tocolytic Agents Phase 2, Phase 3
20 Anti-Arrhythmia Agents Phase 2, Phase 3
21 Calcium, Dietary Phase 2, Phase 3
22 Anesthetics Phase 2, Phase 3,Phase 3
23 Central Nervous System Depressants Phase 2, Phase 3,Phase 3
24 Analgesics Phase 2, Phase 3
25 Hormones Phase 2, Phase 3
26 calcium channel blockers Phase 2, Phase 3
27 Dermatologic Agents Phase 3
28
Histamine Phosphate Phase 3 51-74-1 65513
29 Histamine H1 Antagonists Phase 3
30 Hypnotics and Sedatives Phase 3
31 Anti-Allergic Agents Phase 3
32 Histamine Antagonists Phase 3
33 Gastrointestinal Agents Phase 3
34 Anesthetics, Local Phase 3
35 Neurotransmitter Agents Phase 3
36 Antiemetics Phase 3
37 Antipruritics Phase 3
38 Autonomic Agents Phase 3
39 pyruvate Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimum Thiamine Intervention (OpTIn) Trial Recruiting NCT02788552 Phase 4 Thiamine Hydrochloride
2 Alcohol: Thiamine and or Magnesium 1 Recruiting NCT03466528 Phase 2, Phase 3 Magnesium Sulfate;Pabrinex
3 An Efficacy and Safety Trial of Fedratinib in Subjects With DIPSS, Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib Recruiting NCT03755518 Phase 3 FEDRATINIB
4 An Efficacy and Safety Study of Fedratinib Compared to Best Available Therapy in Subjects With DIPSS-intermediate or High-risk Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib Not yet recruiting NCT03952039 Phase 3 FEDRATINIB;Best Available Therapy (BAT)
5 Does Thiamine Help Vomiting and Nausea in Pregnancy? Terminated NCT00861523 Phase 3 thiamine & promethazine
6 From Uncomplicated Alcoholism to Korsakoff's Syndrome Unknown status NCT01455207 Not Applicable
7 Models of Disordered Knowledge and Memory Systems in Dementia and Related Disorders Completed NCT00004557
8 Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study Recruiting NCT03724136 Not Applicable
9 The Effect of tDCS on Subcortical Brain Functioning Terminated NCT01602276 Not Applicable

Search NIH Clinical Center for Korsakoff's Amnesic Syndrome

Genetic Tests for Korsakoff's Amnesic Syndrome

Anatomical Context for Korsakoff's Amnesic Syndrome

MalaCards organs/tissues related to Korsakoff's Amnesic Syndrome:

42
Brain, Spinal Cord, Hypothalamus, Thalamus

Publications for Korsakoff's Amnesic Syndrome

Articles related to Korsakoff's Amnesic Syndrome:

# Title Authors Year
1
Bilateral cavernous sinus thrombosis causing Korsakoff's amnesic syndrome. ( 7738577 )
1995
2
Cognitive brain potentials and psychological deficits in Alzheimer's dementia and Korsakoff's amnesic syndrome. ( 3602227 )
1987

Variations for Korsakoff's Amnesic Syndrome

Expression for Korsakoff's Amnesic Syndrome

Search GEO for disease gene expression data for Korsakoff's Amnesic Syndrome.

Pathways for Korsakoff's Amnesic Syndrome

GO Terms for Korsakoff's Amnesic Syndrome

Sources for Korsakoff's Amnesic Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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