MCID: KRS005
MIFTS: 12

Korsakoff's Amnesic Syndrome

Aliases & Classifications for Korsakoff's Amnesic Syndrome

MalaCards integrated aliases for Korsakoff's Amnesic Syndrome:

Name: Korsakoff's Amnesic Syndrome 54
Alcohol Induced Encephalopathy 73

External Ids:

UMLS 73 C2931917

Summaries for Korsakoff's Amnesic Syndrome

NINDS : 54 Wernicke's encephalopathy is a degenerative brain disorder caused by the lack of thiamine (vitamin B1). It may result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. B1 deficiency causes damage to the brain's thalamus and hypothalamus. Symptoms include mental confusion, vision problems, coma, hypothermia, low blood pressure, and lack of muscle coordination (ataxia). Korsakoff syndrome (also called Korsakoff's amnesic syndrome) is a memory disorder that results from vitamin B1 deficiency and is associated with alcoholism. Korsakoff's syndrome damages nerve cells and supporting cells in the brain and spinal cord, as well as the part of the brain involved with memory. Symptoms include amnesia, tremor, coma, disorientation, and vision problems, The disorder's main features are problems in acquiring new information or establishing new memories, and in retrieving previous memories. Although Wernicke's and Korsakoff's are related disorders, some scientists believe them to be different stages of the same disorder, which is called Wernicke-Korsakoff syndrome. Wernicke's encephalopathy represents the "acute" phase of the disorder and Korsakoff's amnesic syndrome represents the disorder progressing to a "chronic" or long-lasting stage.

MalaCards based summary : Korsakoff's Amnesic Syndrome, is also known as alcohol induced encephalopathy. The drugs Thiamine and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, hypothalamus and spinal cord.

Related Diseases for Korsakoff's Amnesic Syndrome

Symptoms & Phenotypes for Korsakoff's Amnesic Syndrome

Drugs & Therapeutics for Korsakoff's Amnesic Syndrome

Drugs for Korsakoff's Amnesic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 59-43-8, 70-16-6 1130
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
3 Vitamins Phase 4,Phase 3,Not Applicable
4 Micronutrients Phase 4,Phase 3
5 Trace Elements Phase 4,Phase 3
6 Vitamin B Complex Phase 4,Phase 3
7 Thiamin Nutraceutical Phase 4,Phase 3,Not Applicable
8 Folate Nutraceutical Phase 4,Phase 3
9 Vitamin B9 Nutraceutical Phase 4,Phase 3
10
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
11
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
12
Promethazine Approved, Investigational Phase 3 60-87-7 4927
13
Histamine Phosphate Phase 3 51-74-1 65513
14 Central Nervous System Depressants Phase 3
15 Gastrointestinal Agents Phase 3
16 Neurotransmitter Agents Phase 3
17 Histamine Antagonists Phase 3
18 Histamine H1 Antagonists Phase 3
19 Anesthetics Phase 3
20 Dermatologic Agents Phase 3
21 Anesthetics, Local Phase 3
22 Anti-Allergic Agents Phase 3
23 Peripheral Nervous System Agents Phase 3
24 Hypnotics and Sedatives Phase 3
25 Antiemetics Phase 3
26 Antipruritics Phase 3
27 Autonomic Agents Phase 3
28 pyruvate Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimum Thiamine Intervention (OpTIn) Trial Recruiting NCT02788552 Phase 4 Thiamine Hydrochloride
2 Alcohol: Thiamine and or Magnesium 1 Recruiting NCT03466528 Phase 2, Phase 3 Magnesium Sulfate;Pabrinex
3 Does Thiamine Help Vomiting and Nausea in Pregnancy? Terminated NCT00861523 Phase 3 thiamine & promethazine
4 From Uncomplicated Alcoholism to Korsakoff's Syndrome Unknown status NCT01455207 Not Applicable
5 Models of Disordered Knowledge and Memory Systems in Dementia and Related Disorders Completed NCT00004557
6 The Effect of tDCS on Subcortical Brain Functioning Enrolling by invitation NCT01602276 Not Applicable

Search NIH Clinical Center for Korsakoff's Amnesic Syndrome

Genetic Tests for Korsakoff's Amnesic Syndrome

Anatomical Context for Korsakoff's Amnesic Syndrome

MalaCards organs/tissues related to Korsakoff's Amnesic Syndrome:

41
Brain, Hypothalamus, Spinal Cord, Thalamus

Publications for Korsakoff's Amnesic Syndrome

Articles related to Korsakoff's Amnesic Syndrome:

# Title Authors Year
1
Bilateral cavernous sinus thrombosis causing Korsakoff's amnesic syndrome. ( 7738577 )
1995
2
Cognitive brain potentials and psychological deficits in Alzheimer's dementia and Korsakoff's amnesic syndrome. ( 3602227 )
1987

Variations for Korsakoff's Amnesic Syndrome

Expression for Korsakoff's Amnesic Syndrome

Search GEO for disease gene expression data for Korsakoff's Amnesic Syndrome.

Pathways for Korsakoff's Amnesic Syndrome

GO Terms for Korsakoff's Amnesic Syndrome

Sources for Korsakoff's Amnesic Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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