MCID: KRK001
MIFTS: 40

Krukenberg Carcinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Rare diseases, Reproductive diseases
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Aliases & Classifications for Krukenberg Carcinoma

MalaCards integrated aliases for Krukenberg Carcinoma:

Name: Krukenberg Carcinoma 11 19 14
Krukenberg Tumor 11 19 43 16 71 75
Krukenberg Neoplasm 11
Krukenberg's Tumor 19

Classifications:



External Ids:

Disease Ontology 11 DOID:9597
MeSH 43 D007725
NCIt 49 C3153
SNOMED-CT 68 4305004
UMLS 71 C0022790

Summaries for Krukenberg Carcinoma

Disease Ontology: 11 An ovary epithelial cancer that is a metastatic signet-ring cell carcinoma, which spreads to the ovary from gastric tissue.

MalaCards based summary: Krukenberg Carcinoma, also known as krukenberg tumor, is related to signet ring cell adenocarcinoma and gastric adenocarcinoma. An important gene associated with Krukenberg Carcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. Affiliated tissues include ovary, breast and appendix.

GARD: 19 Metastatic signet-ring cell carcinoma to the ovary. The primary site is the gastrointestinal tract or breast.

Wikipedia: 75 A Krukenberg tumor refers to a malignancy in the ovary that metastasized from a primary site,... more...

Related Diseases for Krukenberg Carcinoma

Diseases related to Krukenberg Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 504)
# Related Disease Score Top Affiliating Genes
1 signet ring cell adenocarcinoma 30.7 KRT7 KRT20 CEACAM5 CDX2
2 gastric adenocarcinoma 30.3 KRT20 CEACAM5 CDX2 AFP
3 adenocarcinoma 30.3 NAPSA KRT7 KRT20 CEACAM5 CDX2
4 small intestine adenocarcinoma 30.2 KRT7 CDX2
5 lymphangitis 30.2 KRT7 CEACAM5
6 transverse colon cancer 30.2 KRT20 CEACAM5
7 cystadenocarcinoma 30.2 PAX8 KRT7 CEACAM5
8 microinvasive gastric cancer 30.2 CEACAM5 CDX2 AFP
9 gallbladder disease 30.1 KRT7 CEACAM5 AFP
10 ovarian cyst 30.1 CEACAM5 AFP
11 linitis plastica 30.1 KRT7 KRT20 CEACAM5 CDX2
12 appendiceal neoplasm 30.0 SATB2 KRT7 CEACAM5 CDX2
13 gallbladder adenocarcinoma 30.0 SYP KRT7 CEACAM5 CDX2
14 collecting duct carcinoma 29.9 PAX8 KRT7
15 ovary adenocarcinoma 29.9 PAX8 KRT7 CEACAM5 CDX2
16 fibroma 29.9 SATB2 KRT7 CALB2
17 endodermal sinus tumor 29.9 KRT7 CEACAM5 AFP
18 pseudomyxoma peritonei 29.9 KRT7 KRT20 CEACAM5 CDX2
19 klatskin's tumor 29.8 KRT7 CEACAM5 AFP
20 ampulla of vater cancer 29.8 KRT7 KRT20 CEACAM5 CDX2
21 colonic benign neoplasm 29.8 KRT7 KRT20 CEACAM5 CDX2
22 leydig cell tumor 29.8 SYP CALB2 AFP
23 mucinous adenofibroma 29.8 SYP KRT7 CEACAM5 CDX2
24 sertoli-leydig cell tumor 29.7 SYP KRT7 CALB2 AFP
25 gallbladder cancer 29.7 KRT7 KRT20 CEACAM5 CDX2 AFP
26 mucinous cystadenocarcinoma 29.6 KRT7 KRT20 CEACAM5 CDX2 AFP
27 cholangiocarcinoma 29.6 KRT7 KRT20 CEACAM5 CDX2 AFP
28 colorectal adenocarcinoma 29.5 SATB2 KRT7 KRT20 CEACAM5 CDX2
29 obstructive jaundice 29.5 SYP KRT7 CEACAM5 AFP
30 adenofibroma 29.5 PAX8 NAPSA KRT7 CALB2
31 appendix adenocarcinoma 29.4 SYP SATB2 KRT7 KRT20 CEACAM5 CDX2
32 carcinosarcoma 29.4 SYP PAX8 KRT7 CALB2
33 mucinous adenocarcinoma 29.2 PAX8 NAPSA KRT7 KRT20 CEACAM5 CDX2
34 lung cancer susceptibility 3 29.2 NAPSA KRT7 KRT20 CEACAM5 CDX2 CALB2
35 ovarian mucinous neoplasm 29.2 SATB2 PAX8 KRT7 KRT20 CEACAM5 CDX2
36 tubular adenocarcinoma 29.1 SYP KRT7 KRT20 CEACAM5 CDX2 AFP
37 cystadenoma 28.9 SYP KRT7 KRT20 CEACAM5 CALB2 AFP
38 ovarian benign neoplasm 28.8 PAX8 KRT7 KRT20 CEACAM5 CALB2 AFP
39 teratoma 28.6 SYP KRT7 KRT20 CEACAM5 CDX2 CALB2
40 renal cell carcinoma, nonpapillary 28.6 PAX8 NAPSA KRT7 KRT20 HNF1B CALB2
41 cystic teratoma 28.2 SYP PAX8 KRT7 KRT20 CEACAM5 CDX2
42 benign teratoma 28.2 SYP PAX8 KRT7 KRT20 CEACAM5 CDX2
43 gastric cancer 10.6
44 diffuse gastric cancer 10.4
45 bladder signet ring cell adenocarcinoma 10.3 KRT7 CDX2
46 apocrine adenocarcinoma 10.3 KRT7 CEACAM5
47 hidradenoma 10.3 KRT7 CEACAM5
48 syringoma 10.3 KRT7 CEACAM5
49 male urethral cancer 10.3 KRT7 KRT20
50 anal canal paget's disease 10.3 KRT7 CDX2

Graphical network of the top 20 diseases related to Krukenberg Carcinoma:



Diseases related to Krukenberg Carcinoma

Symptoms & Phenotypes for Krukenberg Carcinoma

Drugs & Therapeutics for Krukenberg Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicentric Phase III Trial Comparing Simple Follow-up to Exploratory Laparotomy Plus "in Principle" HIPEC (Hyperthermic Intraperitoneal Chemotherapy) in Colorectal Patients Initially Treated With Surgery and Adjuvant Chemotherapy Who Have a High Risk of Developing Colorectal Peritoneal Carcinomatosis Unknown status NCT01226394 Phase 3
2 Impact of Different Treatment Strategies on the Prognosis of Ovarian Metastatic Colorectal Cancer Patients: a Prospective, Multi-center, Real-world Study Recruiting NCT04716257

Search NIH Clinical Center for Krukenberg Carcinoma

Cochrane evidence based reviews: krukenberg tumor

Genetic Tests for Krukenberg Carcinoma

Anatomical Context for Krukenberg Carcinoma

Organs/tissues related to Krukenberg Carcinoma:

MalaCards : Ovary, Breast, Appendix, Lymph Node, Colon, Bone Marrow, Smooth Muscle

Publications for Krukenberg Carcinoma

Articles related to Krukenberg Carcinoma:

(show top 50) (show all 392)
# Title Authors PMID Year
1
Krukenberg tumor in pregnancy: a rare case and review of the literature. 62
34470118 2022
2
Clinics and pathology of Krukenberg tumor: a systematic review and meta-analysis. 62
33944524 2022
3
A retrospective study of clinicopathological characteristics and prognostic factors of Krukenberg tumor with gastric origin. 62
35837152 2022
4
Panorama of multidetector-row computed tomography findings of carcinoma gall bladder - A retrospective observational study. 62
35900538 2022
5
[A case of CA19-9-producing esophagogastric junction cancer with ovarian juvenile granulosa cell tumor and rectal cancer]. 62
35944993 2022
6
Ovarian metastases from colorectal cancer in young women: a systematic review of the literature. 62
34432125 2021
7
Krukenberg Tumor Presentation of Recurrent Gallbladder Cancer After a Decade. 62
34799819 2021
8
Krukenberg Tumor of Ovary During Pregnancy: Learning From A Mistake. 62
33252404 2021
9
Magnifying Power: New Endoscopic Tools for the Diagnosis of Krukenberg Tumor. 62
33433803 2021
10
Incidentally Diagnosed Krukenberg Tumor in a Young Pregnant Woman. 62
34909392 2021
11
Two Concurrent Cancers in a 19-Year-Old Patient: Yolk Sac Ovarian Tumor and Metastatic Gastrointestinal Tract Malignancy-Case Report. 62
33689915 2021
12
Metachronous Krukenberg tumor from adenocarcinoma in a Meckel's diverticulum: a case report. 62
34476080 2021
13
Ovarian metastasis from breast cancer mimicking a primary ovarian neoplasm: A case report. 62
34055350 2021
14
Krukenberg Tumor Manifesting with Hirsutism and Acanthosis Nigricans as the Exclusive Presenting Symptoms. 62
34568197 2021
15
Krukenberg tumor as an incidental finding in a full-term pregnancy: a case report. 62
34049591 2021
16
Renal Cell Carcinoma Mimicking with Peritoneal Carcinomatosis and Krukenberg Tumor: Diagnosis Seen on Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography. 62
34385798 2021
17
Primary mucinous ovarian tumors vs. ovarian metastases from gastrointestinal tract, pancreas and biliary tree: a review of current problematics. 62
33706757 2021
18
Krukenberg tumor with concomitant ipsilateral hydronephrosis and spermatic cord metastasis in a man: A case report. 62
33511197 2021
19
A comparative study of RTK gene status between primary tumors, lymph-node metastases, and Krukenberg tumors. 62
32732929 2021
20
Epidemiology of ovarian cancer. 62
32648448 2020
21
A Rare Malignity of Childhood: Krukenberg Tumor-Case Report and Review of Literature. 62
31660771 2020
22
Krukenberg Tumor in Association with Ureteral Stenosis Due to Peritoneal Carcinomatosis from Pulmonary Adenocarcinoma: A Case Report. 62
32316633 2020
23
Krukenberg tumor. 62
33344281 2020
24
CDX2, SATB2, GATA3, TTF1, and PAX8 Immunohistochemistry in Krukenberg Tumors. 62
32045390 2020
25
Ovarian tumors: a survey of selected advances of note during the life of this journal. 62
31654691 2020
26
[A Case of Superficial-Type Gastric Cancer with Metastatic Ovarian Cancer Diagnosed by Exploratory Laparotomy]. 62
32381891 2020
27
Prognostic factors in Krukenberg tumor. 62
31542818 2019
28
A rare case of Krukenberg tumor by gallbladder cancer. 62
31641505 2019
29
Effects of metastasectomy and other factors on survival of patients with ovarian metastases from gastric cancer: a systematic review and meta-analysis. 62
31050365 2019
30
An Epithelioid Smooth Muscle Neoplasm Mimicking a Signet Ring Cell Carcinoma in the Ovary. 62
29750703 2019
31
Krukenberg Tumor Secondary to Lung Adenocarcinoma. 62
30545640 2019
32
Treatments and overall survival in patients with Krukenberg tumor. 62
31044302 2019
33
[Diagnosis and treatment strategy of gastric cancer with ovarian metastasis]. 62
30917451 2019
34
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a patient with peritoneal carcinomatosis from a pancreatic cystadenocarcinoma: A case report. 62
31563663 2019
35
A rare case of synchronous ovarian tumors: clinical case report and literature review. 62
32239119 2019
36
[Krukenberg tumour: about 5 cases]. 62
31934248 2019
37
Measurable Krukenberg tumor is preferably characterized as a non-target lesion in the clinical evaluation of gastric cancer therapeutics: A case report. 62
30546891 2018
38
Extensive Paneth cell metaplasia in an ovarian Krukenberg tumor: report of an unusual case and literature review. 62
30555671 2018
39
Ovarian Metastases of Breast Cancers With Signet Ring Cells: A Report of 17 Cases Including 14 Krukenberg Tumors. 62
29045292 2018
40
Glioblastoma metastatic to the ovary, a very different Krukenberg tumor? 62
29861347 2018
41
Torsion Ovary, an Unusual Presentation of Carcinoma Appendix Detected in Whole-Body F-18 2-Fluoro 2-deoxy Glucose Positron Emission Tomography/Computed Tomography Scan. 62
30386056 2018
42
Signet Ring Stromal Cell Tumor: A Legitimate (Benign) Mimic of Krukenberg Tumor. 62
30281366 2018
43
[Clinicopathologic analysis of primary carcinoid of the ovary]. 62
29996316 2018
44
Malignant phyllodes tumor metastatic to bilateral ovaries: A Krukenberg-like presentation. 62
30197364 2018
45
Signet Ring Cell Carcinoma of Unknown Primary Complicated with Pulmonary Tumor Thrombotic Microangiopathy and Krukenberg Tumor. 62
30057535 2018
46
Pressurized intraperitoneal aerosol chemotheprapy after misdiagnosed gastric cancer: Case report and review of the literature. 62
29785081 2018
47
A rare Krukenberg tumor arising from a primary adenocarcinoma of the small intestine. 62
29673681 2018
48
ERRATUM: Comparison of Surgery Plus Chemotherapy and Palliative Chemotherapy Alone for Advanced Gastric Cancer with Krukenberg Tumor. 62
29216420 2018
49
PD-L1 Expression Predicts a Distinct Prognosis in Krukenberg Tumor with Corresponding Origins. 62
29854854 2018
50
Is a Surgical Approach Justified in Metachronous Krukenberg Tumor from Gastric Cancer? A Systematic Review. 62
30205375 2018

Variations for Krukenberg Carcinoma

Cosmic variations for Krukenberg Carcinoma:

8 (show top 50) (show all 239)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87905773 TP53 ovary,NS,carcinoma,adenocarcinoma c.542G>A p.R181H 17:7675070-7675070 7
2 COSM111761369 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 7
3 COSM142841902 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 7
4 COSM122736483 TP53 ovary,NS,carcinoma,adenocarcinoma c.-2A>G p.? 17:7675217-7675217 7
5 COSM145024458 TP53 ovary,NS,carcinoma,adenocarcinoma c.425G>A p.R142H 17:7675070-7675070 7
6 COSM121879352 TP53 ovary,NS,carcinoma,adenocarcinoma c.-2A>G p.? 17:7675217-7675217 7
7 COSM93190033 TP53 ovary,NS,carcinoma,adenocarcinoma c.542G>A p.R181H 17:7675070-7675070 7
8 COSM106059013 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 7
9 COSM144315389 TP53 ovary,NS,carcinoma,adenocarcinoma c.425G>A p.R142H 17:7675070-7675070 7
10 COSM105621213 TP53 ovary,NS,carcinoma,adenocarcinoma c.578A>T p.H193L 17:7674953-7674953 7
11 COSM143373513 TP53 ovary,NS,carcinoma,adenocarcinoma c.278A>G p.K93R 17:7675217-7675217 7
12 COSM111764887 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 7
13 COSM106053540 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 7
14 COSM143157087 TP53 ovary,NS,carcinoma,adenocarcinoma c.439C>T p.R147* 17:7673704-7673704 7
15 COSM144087635 TP53 ovary,NS,carcinoma,adenocarcinoma c.101A>T p.H34L 17:7674953-7674953 7
16 COSM122277330 TP53 ovary,NS,carcinoma,adenocarcinoma c.80C>T p.A27V 17:7675136-7675136 7
17 COSM145018055 TP53 ovary,NS,carcinoma,adenocarcinoma c.799C>T p.R267* 17:7673704-7673704 7
18 COSM142839188 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 7
19 COSM111759372 TP53 ovary,NS,carcinoma,adenocarcinoma c.578A>T p.H193L 17:7674953-7674953 7
20 COSM144091170 TP53 ovary,NS,carcinoma,adenocarcinoma c.-2C>T p.? 17:7675136-7675136 7
21 COSM112259200 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 7
22 COSM111758977 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 7
23 COSM121883809 TP53 ovary,NS,carcinoma,adenocarcinoma c.146G>A p.R49H 17:7675070-7675070 7
24 COSM105627180 TP53 ovary,NS,carcinoma,adenocarcinoma c.542G>A p.R181H 17:7675070-7675070 7
25 COSM145018520 TP53 ovary,NS,carcinoma,adenocarcinoma c.461A>T p.H154L 17:7674953-7674953 7
26 COSM145023722 TP53 ovary,NS,carcinoma,adenocarcinoma c.359C>T p.A120V 17:7675136-7675136 7
27 COSM122739810 TP53 ovary,NS,carcinoma,adenocarcinoma c.80C>T p.A27V 17:7675136-7675136 7
28 COSM121877099 TP53 ovary,NS,carcinoma,adenocarcinoma c.182A>T p.H61L 17:7674953-7674953 7
29 COSM93186307 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 7
30 COSM122740180 TP53 ovary,NS,carcinoma,adenocarcinoma c.146G>A p.R49H 17:7675070-7675070 7
31 COSM122734810 TP53 ovary,NS,carcinoma,adenocarcinoma c.182A>T p.H61L 17:7674953-7674953 7
32 COSM142837646 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 7
33 COSM143376903 TP53 ovary,NS,carcinoma,adenocarcinoma c.359C>T p.A120V 17:7675136-7675136 7
34 COSM143944663 TP53 ovary,NS,carcinoma,adenocarcinoma c.101A>T p.H34L 17:7674953-7674953 7
35 COSM144088998 TP53 ovary,NS,carcinoma,adenocarcinoma c.-83A>G p.? 17:7675217-7675217 7
36 COSM144315052 TP53 ovary,NS,carcinoma,adenocarcinoma c.359C>T p.A120V 17:7675136-7675136 7
37 COSM142565939 TP53 ovary,NS,carcinoma,adenocarcinoma c.359C>T p.A120V 17:7675136-7675136 7
38 COSM142837920 TP53 ovary,NS,carcinoma,adenocarcinoma c.578A>T p.H193L 17:7674953-7674953 7
39 COSM142560671 TP53 ovary,NS,carcinoma,adenocarcinoma c.799C>T p.R267* 17:7673704-7673704 7
40 COSM87899223 TP53 ovary,NS,carcinoma,adenocarcinoma c.578A>T p.H193L 17:7674953-7674953 7
41 COSM105623043 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 7
42 COSM144013781 TP53 ovary,NS,carcinoma,adenocarcinoma c.883C>T p.R295* 17:7673704-7673704 7
43 COSM87898818 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 7
44 COSM142566344 TP53 ovary,NS,carcinoma,adenocarcinoma c.425G>A p.R142H 17:7675070-7675070 7
45 COSM105626845 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 7
46 COSM143162071 TP53 ovary,NS,carcinoma,adenocarcinoma c.65G>A p.R22H 17:7675070-7675070 7
47 COSM143159037 TP53 ovary,NS,carcinoma,adenocarcinoma c.-83A>G p.? 17:7675217-7675217 7
48 COSM144651539 TP53 ovary,NS,carcinoma,adenocarcinoma c.799C>T p.R267* 17:7673704-7673704 7
49 COSM122734486 TP53 ovary,NS,carcinoma,adenocarcinoma c.520C>T p.R174* 17:7673704-7673704 7
50 COSM143946472 TP53 ovary,NS,carcinoma,adenocarcinoma c.-83A>G p.? 17:7675217-7675217 7

Expression for Krukenberg Carcinoma

Search GEO for disease gene expression data for Krukenberg Carcinoma.

Pathways for Krukenberg Carcinoma

Pathways related to Krukenberg Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.92 HNF1B CDX2 AFP

GO Terms for Krukenberg Carcinoma

Biological processes related to Krukenberg Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pronephros development GO:0048793 9.46 PAX8 HNF1B
2 mesonephric tubule development GO:0072164 8.96 PAX8 HNF1B
3 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 8.92 PAX8 HNF1B

Sources for Krukenberg Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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