MCID: KRK001
MIFTS: 33

Krukenberg Carcinoma

Categories: Rare diseases, Endocrine diseases, Reproductive diseases, Cancer diseases

Aliases & Classifications for Krukenberg Carcinoma

MalaCards integrated aliases for Krukenberg Carcinoma:

Name: Krukenberg Carcinoma 12 53 15
Krukenberg Tumor 12 53 44 73
Krukenberg Neoplasm 12
Krukenberg’s Tumor 53

Classifications:



External Ids:

Disease Ontology 12 DOID:9597
MeSH 44 D007725
NCIt 50 C3153
UMLS 73 C0022790

Summaries for Krukenberg Carcinoma

MalaCards based summary : Krukenberg Carcinoma, also known as krukenberg tumor, is related to mucinous cystadenocarcinoma and transverse colon cancer. An important gene associated with Krukenberg Carcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways is Type II diabetes mellitus. The drugs Mitomycins and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, appendix and colon.

Wikipedia : 76 A Krukenberg tumor refers to a malignancy in the ovary that metastasized from a primary site,... more...

Related Diseases for Krukenberg Carcinoma

Diseases related to Krukenberg Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 mucinous cystadenocarcinoma 30.6 KRT20 KRT7
2 transverse colon cancer 30.3 KRT20 KRT7
3 mucinous adenocarcinoma 30.3 KRT20 KRT7
4 ovarian cancer 1 29.8 HNF1B KRT7
5 ovarian benign neoplasm 10.5 KRT7 NAPSA
6 papillary adenoma 10.5 KRT7 NAPSA
7 cystic basal cell carcinoma 10.4 KRT20 KRT7
8 vaginal benign neoplasm 10.4 KRT20 KRT7
9 seminal vesicle adenocarcinoma 10.4 KRT20 KRT7
10 appendix adenocarcinoma 10.4 KRT20 KRT7
11 ovarian large-cell neuroendocrine carcinoma 10.4 KRT20 KRT7
12 vaginal adenoma 10.4 KRT20 KRT7
13 vaginal tubulovillous adenoma 10.4 KRT20 KRT7
14 eyelid neoplasm 10.4 KRT20 KRT7
15 glandular cystitis 10.4 KRT20 KRT7
16 malignant syringoma 10.4 KRT20 KRT7
17 large intestine adenocarcinoma 10.4 KRT20 KRT7
18 linitis plastica 10.4 KRT20 KRT7
19 lung acinar adenocarcinoma 10.4 KRT20 KRT7
20 small cell carcinoma of the bladder 10.4 KRT20 KRT7
21 adenoid squamous cell carcinoma 10.4 KRT20 KRT7
22 eccrine sweat gland neoplasm 10.4 KRT20 KRT7
23 mucinous bronchioloalveolar adenocarcinoma 10.4 KRT20 KRT7
24 vulval paget's disease 10.4 KRT20 KRT7
25 bile duct cystadenocarcinoma 10.4 KRT20 KRT7
26 intratubular embryonal carcinoma 10.4 KRT20 KRT7
27 ovarian mucinous adenocarcinoma 10.4 KRT20 KRT7
28 gastric diffuse adenocarcinoma 10.4 KRT20 KRT7
29 meibomian cyst 10.4 KRT20 KRT7
30 bladder lymphoma 10.4 KRT20 KRT7
31 papillary serous adenocarcinoma 10.4 KRT20 KRT7
32 bladder adenocarcinoma 10.4 KRT20 KRT7
33 jejunal adenocarcinoma 10.4 KRT20 KRT7
34 chronic cystitis 10.4 KRT20 KRT7
35 vulva adenocarcinoma 10.4 KRT20 KRT7
36 medulloepithelioma 10.4 KRT20 KRT7
37 glycogen-rich clear cell breast carcinoma 10.4 KRT20 KRT7
38 rectum adenocarcinoma 10.4 KRT20 KRT7
39 renal pelvis carcinoma 10.4 KRT20 KRT7
40 paget disease, extramammary 10.4 KRT20 KRT7
41 ampulla of vater neoplasm 10.4 KRT20 KRT7
42 appendix cancer 10.4 KRT20 KRT7
43 ampulla of vater adenocarcinoma 10.4 KRT20 KRT7
44 biliary papillomatosis 10.4 KRT20 KRT7
45 lymphoepithelioma-like carcinoma 10.4 KRT20 KRT7
46 endocervical adenocarcinoma 10.4 KRT20 KRT7
47 infiltrative basal cell carcinoma 10.4 KRT20 KRT7
48 immune system organ benign neoplasm 10.3 KRT20 KRT7
49 thymus lipoma 10.3 KRT20 KRT7
50 cystadenofibroma 10.3 KRT20 KRT7

Graphical network of the top 20 diseases related to Krukenberg Carcinoma:



Diseases related to Krukenberg Carcinoma

Symptoms & Phenotypes for Krukenberg Carcinoma

Drugs & Therapeutics for Krukenberg Carcinoma

Drugs for Krukenberg Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitomycins Phase 3,Phase 1,Phase 2,Not Applicable
2
Cisplatin Approved Phase 1, Phase 2 15663-27-1 84093 441203 2767
3 Alkylating Agents Phase 1, Phase 2
4 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
5 Anti-Bacterial Agents Phase 1, Phase 2
6 Antibiotics, Antitubercular Phase 1, Phase 2
7 Cola Nutraceutical Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Oophorectomy Followed by Chemotherapy Versus Chemotherapy Alone in Colorectal Cancer Patients Completed NCT01483443 Phase 3
2 Trial Comparing Simple Follow-up to Exploratory Laparotomy Plus "in Principle" (Hyperthermic Intraperitoneal Chemotherapy) HIPEC in Colorectal Patients Recruiting NCT01226394 Phase 3
3 Trial Evaluating Surgery With Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Treating Patients With a High Risk of Developing Colorectal Peritoneal Carcinomatosis Recruiting NCT02179489 Phase 3
4 Adjuvant HIPEC to Prevent Colorectal Peritoneal Metastases in High-risk Patients Completed NCT02575859 Phase 1, Phase 2 adjuvant HIPEC
5 Prophylactic HIPEC for Colorectal Cancers at High Risk of Developing Peritoneal Metastases Recruiting NCT03422432 Not Applicable
6 Investigating Minimal Residual Disease in Autopreserved Ovarian Tissue in Cases of Neoplastic Pathology Recruiting NCT02888145
7 Validation of a Method to Search Residual Disease in Auto-cryopreserved Ovarian Tissues Recruiting NCT02900625

Search NIH Clinical Center for Krukenberg Carcinoma

Cochrane evidence based reviews: krukenberg tumor

Genetic Tests for Krukenberg Carcinoma

Anatomical Context for Krukenberg Carcinoma

MalaCards organs/tissues related to Krukenberg Carcinoma:

41
Ovary, Appendix, Colon, Endothelial, Bone Marrow, Bone, Testes

Publications for Krukenberg Carcinoma

Articles related to Krukenberg Carcinoma:

(show all 24)
# Title Authors Year
1
Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report. ( 28693131 )
2017
2
Krukenberg carcinoma metastasized from stomach resembling mucinous cystadenocarcinoma of the ovary. ( 28976119 )
2017
3
Exophthalmos Revealing a Krukenberg Tumor: A Case Presentation and Review of the Literature. ( 27721760 )
2016
4
Krukenberg tumor presenting with amenorrhea as the sole initial symptom: Case report and review of the literature. ( 26881586 )
2015
5
Krukenberg carcinoma metastasized from stomach resembling mucinous cystadenocarcinoma of the ovary. ( 26259386 )
2015
6
Krukenberg tumor secondary to an incidentally discovered gall bladder carcinoma: a rare occurrence. ( 25368464 )
2014
7
Krukenberg tumor presenting as back pain and a positive urine pregnancy test: a case report and literature review. ( 24708577 )
2014
8
Krukenberg tumor after gastric bypass for morbid obesity. Bariatric surgery and gastric cancer. ( 23971662 )
2013
9
A case of Krukenberg carcinoma metastasized from colon cancer resembling mucinous cystadenocarcinoma of the ovary. ( 24427362 )
2013
10
Metastasectomy of Krukenberg tumors may be associated with survival benefits in patients with metastatic gastric cancer. ( 22843921 )
2012
11
Krukenberg tumors from colorectal cancer: presentation, treatment and outcomes. ( 22127094 )
2011
12
MDP uptake in peritoneal carcinomatosis and Krukenberg tumors from mucinous adenocarcinoma. ( 21285688 )
2011
13
Primary ovarian mucinous tumors with signet ring cells: report of 3 cases with discussion of so-called primary Krukenberg tumor. ( 18670351 )
2008
14
The power Doppler velocity index, pulsatility index, and resistive index can assist in making a differential diagnosis of primary ovarian carcinoma and Krukenberg tumors: a preliminary study. ( 17592055 )
2007
15
Krukenberg tumor mimicking pregnancy luteoma. ( 17852427 )
2007
16
Ovarian metastases of intestinal-type gastric carcinoma: A clinicopathologic study of 4 cases with contrasting features to those of the Krukenberg tumor. ( 17063077 )
2006
17
Expression and correlation of CD44v6, vascular endothelial growth factor, matrix metalloproteinase-2, and matrix metalloproteinase-9 in Krukenberg tumor. ( 16124061 )
2005
18
Signet-ring stromal tumor of the ovary: clinicopathologic analysis and comparison with Krukenberg tumor. ( 14668550 )
2004
19
Meningeal carcinomatosis as the initial manifestation of a gallbladder adenocarcinoma associated with a Krukenberg tumor. ( 12894314 )
2003
20
Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature. ( 11435017 )
2001
21
Krukenberg tumor of ovary with features of mucinous cystadenocarcinoma. ( 10921229 )
1999
22
Adenocarcinoid tumor of appendix presenting as unilateral Krukenberg tumor. ( 2826924 )
1988
23
Primary mucinous adenocarcinoma of the appendix with bilateral Krukenberg tumors of the ovary and primary adenocarcinoma of the endometrium. ( 6094317 )
1984
24
Krukenberg carcinoma of the ovary with bone marrow involvement. Report of 2 cases and review of the literature. ( 6243408 )
1980

Variations for Krukenberg Carcinoma

Expression for Krukenberg Carcinoma

Search GEO for disease gene expression data for Krukenberg Carcinoma.

Pathways for Krukenberg Carcinoma

Pathways related to Krukenberg Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.61 CACNA1B HNF1B

GO Terms for Krukenberg Carcinoma

Biological processes related to Krukenberg Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 8.62 KRT20 KRT7

Sources for Krukenberg Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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