MCID: KRK001
MIFTS: 37

Krukenberg Carcinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Krukenberg Carcinoma

MalaCards integrated aliases for Krukenberg Carcinoma:

Name: Krukenberg Carcinoma 12 52 15
Krukenberg Tumor 12 52 43 17 71
Krukenberg Neoplasm 12
Krukenberg's Tumor 52

Classifications:



External Ids:

Disease Ontology 12 DOID:9597
MeSH 43 D007725
NCIt 49 C3153
SNOMED-CT 67 4305004 94455000
UMLS 71 C0022790

Summaries for Krukenberg Carcinoma

Disease Ontology : 12 An ovary epithelial cancer that is a metastatic signet-ring cell carcinoma, which spreads to the ovary from gastric tissue.

MalaCards based summary : Krukenberg Carcinoma, also known as krukenberg tumor, is related to microinvasive gastric cancer and adenofibroma. An important gene associated with Krukenberg Carcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways is Cell adhesion_Cell-matrix glycoconjugates. The drug Mitomycins has been mentioned in the context of this disorder. Affiliated tissues include ovary, breast and colon.

Wikipedia : 74 A Krukenberg tumor refers to a malignancy in the ovary that metastasized from a primary site,... more...

Related Diseases for Krukenberg Carcinoma

Diseases related to Krukenberg Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 381)
# Related Disease Score Top Affiliating Genes
1 microinvasive gastric cancer 30.5 CEACAM5 CDX2
2 adenofibroma 30.4 MUC1 KRT7
3 cystadenocarcinoma 30.2 MUC1 KRT7 CEACAM5
4 mature teratoma 30.2 SYP KRT7 CEACAM5
5 transverse colon cancer 30.1 KRT7 KRT20 CEACAM5
6 ovarian benign neoplasm 30.1 KRT7 KRT20 CEACAM5
7 linitis plastica 30.0 KRT7 KRT20 CEACAM5 CDX2
8 signet ring cell adenocarcinoma 29.9 MUC1 KRT7 KRT20 CEACAM5 CDX2
9 gastric adenocarcinoma 29.8 MUC1 KRT7 KRT20 CEACAM5 CDX2
10 mucinous cystadenocarcinoma 29.8 MUC1 KRT7 KRT20 CEACAM5
11 sertoli-leydig cell tumor 29.7 SYP MUC1 KRT7
12 intrahepatic cholangiocarcinoma 29.7 MUC1 KRT7 KRT20 CDX2
13 mucinous adenofibroma 29.6 SYP KRT7 CEACAM5 CDX2
14 adenocarcinoma 29.6 NAPSA MUC1 KRT7 KRT20 CEACAM5 CDX2
15 gallbladder cancer 29.5 MUC1 KRT7 CEACAM5 CDX2
16 cystic teratoma 29.4 SYP KRT7 KRT20 CEACAM5 CDX2
17 gastrointestinal carcinoma 29.4 MUC1 KRT20 CEACAM5 CDX2
18 appendiceal neoplasm 29.4 SATB2 KRT7 CEACAM5 CDX2
19 benign teratoma 29.3 SYP KRT7 KRT20 CEACAM5 CDX2
20 cholangiocarcinoma 29.3 MUC1 KRT7 KRT20 CEACAM5 CDX2
21 mucinous adenocarcinoma 29.1 MUC1 KRT7 KRT20 CEACAM5 CDX2
22 teratoma 29.1 SYP KRT7 KRT20 CEACAM5 CDX2
23 pseudomyxoma peritonei 29.1 MUC1 KRT7 KRT20 CEACAM5 CDX2
24 cystadenoma 28.9 SYP MUC1 KRT7 KRT20 CEACAM5
25 lung cancer susceptibility 3 28.8 NAPSA MUC1 KRT7 KRT20 CEACAM5 CDX2
26 ovarian mucinous neoplasm 28.8 SATB2 KRT7 KRT20 CEACAM5 CDX2
27 tubular adenocarcinoma 28.7 SYP MUC1 KRT7 KRT20 CEACAM5 CDX2
28 renal cell carcinoma, nonpapillary 28.6 NAPSA MUC1 KRT7 KRT20 HNF1B
29 appendix cancer 28.4 SATB2 MUC1 KRT7 KRT20 CEACAM5 CDX2
30 appendix adenocarcinoma 28.2 SYP SATB2 KRT7 KRT20 CEACAM5 CDX2
31 gastric cancer 10.6
32 ovarian cystadenoma 10.4 KRT7 CEACAM5
33 malignant spiradenoma 10.4 KRT7 CEACAM5
34 cutaneous mucoepidermoid carcinoma 10.4 KRT7 CEACAM5
35 apocrine adenoma 10.4 KRT7 CEACAM5
36 vulval paget's disease 10.4 KRT7 CEACAM5
37 sigmoid neoplasm 10.4 KRT7 CEACAM5
38 eccrine adenocarcinoma 10.4 KRT7 CEACAM5
39 renal pelvis adenocarcinoma 10.4 KRT7 CEACAM5
40 external ear carcinoma 10.4 KRT7 CEACAM5
41 bladder signet ring cell adenocarcinoma 10.4 KRT7 CDX2
42 anal canal paget's disease 10.4 KRT7 CDX2
43 adenosquamous colon carcinoma 10.4 KRT7 CDX2
44 nasal cavity adenocarcinoma 10.4 KRT7 CDX2
45 anus adenocarcinoma 10.4 KRT7 CDX2
46 clear cell hidradenoma 10.4 KRT7 CEACAM5
47 hidrocystoma 10.4 KRT7 CEACAM5
48 liver sarcoma 10.4 KRT7 CEACAM5
49 benign mesothelioma 10.4 KRT7 CEACAM5
50 pericardium cancer 10.4 KRT7 CEACAM5

Graphical network of the top 20 diseases related to Krukenberg Carcinoma:



Diseases related to Krukenberg Carcinoma

Symptoms & Phenotypes for Krukenberg Carcinoma

Drugs & Therapeutics for Krukenberg Carcinoma

Drugs for Krukenberg Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitomycins Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Multicentric Phase III Trial Comparing Simple Surgery to Surgery Plus HIPEC (Hyperthermic Intraperitoneal Chemotherapy) With MMC in Colorectal Patients Who Have a High Risk of Developing Colorectal Peritoneal Carcinomatosis Recruiting NCT02179489 Phase 3

Search NIH Clinical Center for Krukenberg Carcinoma

Cochrane evidence based reviews: krukenberg tumor

Genetic Tests for Krukenberg Carcinoma

Anatomical Context for Krukenberg Carcinoma

MalaCards organs/tissues related to Krukenberg Carcinoma:

40
Ovary, Breast, Colon, Lung, Appendix, Kidney, Bone

Publications for Krukenberg Carcinoma

Articles related to Krukenberg Carcinoma:

(show top 50) (show all 297)
# Title Authors PMID Year
1
A rare case of Krukenberg tumor by gallbladder cancer. 61
31641505 2019
2
Prognostic factors in Krukenberg tumor. 61
31542818 2019
3
A Rare Malignity of Childhood: Krukenberg Tumor-Case Report and Review of Literature. 61
31660771 2019
4
Ovarian tumors: a survey of selected advances of note during the life of this journal. 61
31654691 2019
5
An Epithelioid Smooth Muscle Neoplasm Mimicking a Signet Ring Cell Carcinoma in the Ovary. 61
29750703 2019
6
Effects of metastasectomy and other factors on survival of patients with ovarian metastases from gastric cancer: a systematic review and meta-analysis. 61
31050365 2019
7
Krukenberg Tumor Secondary to Lung Adenocarcinoma. 61
30545640 2019
8
Treatments and overall survival in patients with Krukenberg tumor. 61
31044302 2019
9
[Diagnosis and treatment strategy of gastric cancer with ovarian metastasis]. 61
30917451 2019
10
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a patient with peritoneal carcinomatosis from a pancreatic cystadenocarcinoma: A case report. 61
31563663 2019
11
[Krukenberg tumour: about 5 cases]. 61
31934248 2019
12
Extensive Paneth cell metaplasia in an ovarian Krukenberg tumor: report of an unusual case and literature review. 61
30555671 2018
13
Measurable Krukenberg tumor is preferably characterized as a non-target lesion in the clinical evaluation of gastric cancer therapeutics: A case report. 61
30546891 2018
14
Glioblastoma metastatic to the ovary, a very different Krukenberg tumor? 61
29861347 2018
15
Ovarian Metastases of Breast Cancers With Signet Ring Cells: A Report of 17 Cases Including 14 Krukenberg Tumors. 61
29045292 2018
16
Signet Ring Stromal Cell Tumor: A Legitimate (Benign) Mimic of Krukenberg Tumor. 61
30281366 2018
17
Torsion Ovary, an Unusual Presentation of Carcinoma Appendix Detected in Whole-Body F-18 2-Fluoro 2-deoxy Glucose Positron Emission Tomography/Computed Tomography Scan. 61
30386056 2018
18
Malignant phyllodes tumor metastatic to bilateral ovaries: A Krukenberg-like presentation. 61
30197364 2018
19
[Clinicopathologic analysis of primary carcinoid of the ovary]. 61
29996316 2018
20
Signet Ring Cell Carcinoma of Unknown Primary Complicated with Pulmonary Tumor Thrombotic Microangiopathy and Krukenberg Tumor. 61
30057535 2018
21
Pressurized intraperitoneal aerosol chemotheprapy after misdiagnosed gastric cancer: Case report and review of the literature. 61
29785081 2018
22
A rare Krukenberg tumor arising from a primary adenocarcinoma of the small intestine. 61
29673681 2018
23
ERRATUM: Comparison of Surgery Plus Chemotherapy and Palliative Chemotherapy Alone for Advanced Gastric Cancer with Krukenberg Tumor. 61
29216420 2018
24
Is a Surgical Approach Justified in Metachronous Krukenberg Tumor from Gastric Cancer? A Systematic Review. 61
30205375 2018
25
PD-L1 Expression Predicts a Distinct Prognosis in Krukenberg Tumor with Corresponding Origins. 61
29854854 2018
26
Comparison of a Panel of Biomarkers Between Gastric Primary Cancer and the Paired Krukenberg Tumor. 61
26945444 2017
27
In utero virilization secondary to a maternal Krukenberg tumor: case report and review of literature. 61
28682787 2017
28
Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report. 61
28693131 2017
29
Synchronous hepatic metastasis and metachronous Krukenberg tumor from advanced colon cancer. A case report with an unexpected disease-free survival. 61
28012330 2017
30
Transcoelomic spread and ovarian seeding during ovulation: A possible pathogenesis of Krukenberg tumor. 61
28508852 2017
31
Bilateral Symmetrical Solid Ovarian Masses: Think Krukenberg Tumor. 61
27060533 2016
32
Feto-maternal outcomes of pregnancy complicated by Krukenberg tumor: a systematic review of literature. 61
26897498 2016
33
Misdiagnosed ovarian Krukenberg tumor during pregnancy with virilization. 61
29894093 2016
34
Exophthalmos Revealing a Krukenberg Tumor: A Case Presentation and Review of the Literature. 61
27721760 2016
35
Occult gastric cancer with distant metastasis proven by random gastric biopsy. 61
27122678 2016
36
Ovarian Tumors: Pattern of Histomorphological Types- A 10 Years Study in a Tertiary Referral Center and Review of Literature. 61
28166073 2016
37
Krukenberg Tumors of Gastric Origin: The Rationale of Surgical Resection and Perioperative Treatments in a Multicenter Western Experience. 61
26552908 2016
38
Postmenopausal vaginal bleeding as initial presentation of gastric cancer: a case report with literature review of prognostic factors and treatment of krukenberg tumor. 61
27004231 2016
39
Neuroendocrine Cancer of Rectum Metastasizing to Ovary. 61
27293931 2016
40
Sigmoid colonic metastasis by lymphatic spread occurring with unilateral Krukenberg tumor considered to be caused by stage IA early gastric cancer: A case report. 61
26870264 2016
41
Krukenberg tumor in a 18-year-old-female: a rare case. 61
27048128 2016
42
[Diagnostic value of combined detection of HNF-1β and Napsin A in the diagnosis of ovarian clear cell carcinoma]. 61
26888504 2015
43
Appendiceal mixed adenoneuroendocrine carcinomas, a rare entity that can present as a Krukenberg tumor: case report and review of the literature. 61
26612593 2015
44
Clinical characteristics and prognostic analysis of Krukenberg tumor. 61
26807242 2015
45
A 36-year-old female with Krukenberg tumor from a colonic carcinoma. 61
26881540 2015
46
Comparison of Surgery Plus Chemotherapy and Palliative Chemotherapy Alone for Advanced Gastric Cancer with Krukenberg Tumor. 61
25648093 2015
47
Krukenberg tumor presenting with amenorrhea as the sole initial symptom: Case report and review of the literature. 61
26881586 2015
48
Metastatic Ovarian Tumor Masquerading as Atypical Pneumonia. 61
26742194 2015
49
GAGE12 mediates human gastric carcinoma growth and metastasis. 61
25346337 2015
50
Isolated Krukenberg tumor in pregnancy. 61
25951735 2015

Variations for Krukenberg Carcinoma

Cosmic variations for Krukenberg Carcinoma:

9 (show top 50) (show all 239)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87905773 TP53 ovary,NS,carcinoma,adenocarcinoma c.542G>A p.R181H 17:7675070-7675070 6
2 COSM87899223 TP53 ovary,NS,carcinoma,adenocarcinoma c.578A>T p.H193L 17:7674953-7674953 6
3 COSM87898818 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 6
4 COSM87905366 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 6
5 COSM87901171 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 6
6 COSM145422024 TNFAIP3 ovary,NS,carcinoma,adenocarcinoma c.940G>A p.V314I 6:137877210-137877210 6
7 COSM91381505 SMAD4 ovary,NS,carcinoma,adenocarcinoma c.1051G>C p.D351H 18:51065518-51065518 6
8 COSM88349172 SMAD2 ovary,NS,carcinoma,adenocarcinoma c.785-1G>C p.? 18:47848688-47848688 6
9 COSM92365507 RET ovary,NS,carcinoma,adenocarcinoma c.3253A>G p.T1085A 10:43128177-43128177 6
10 COSM90833519 PTCH1 ovary,NS,carcinoma,adenocarcinoma c.3074G>A p.R1025H 9:95458107-95458107 6
11 COSM87152527 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.1034A>T p.N345I 3:179203764-179203764 6
12 COSM87132544 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.1636C>A p.Q546K 3:179218306-179218306 6
13 COSM87132301 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.1624G>A p.E542K 3:179218294-179218294 6
14 COSM87145727 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.3012G>T p.M1004I 3:179234169-179234169 6
15 COSM87139234 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.2725T>C p.F909L 3:179230062-179230062 6
16 COSM87133231 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.263G>A p.R88Q 3:179199088-179199088 6
17 COSM97107326 NRAS ovary,NS,carcinoma,adenocarcinoma c.181C>A p.Q61K 1:114713909-114713909 6
18 COSM97107379 NRAS ovary,NS,carcinoma,adenocarcinoma c.35G>A p.G12D 1:114716126-114716126 6
19 COSM87804005 KRAS ovary,NS,carcinoma,adenocarcinoma c.35G>A p.G12D 12:25245350-25245350 6
20 COSM87804083 KRAS ovary,NS,carcinoma,adenocarcinoma c.35G>C p.G12A 12:25245350-25245350 6
21 COSM87804055 KRAS ovary,NS,carcinoma,adenocarcinoma c.35G>T p.G12V 12:25245350-25245350 6
22 COSM88586417 ERBB2 ovary,NS,carcinoma,adenocarcinoma c.2524G>A p.V842I 17:39725079-39725079 6
23 COSM86804346 EGFR ovary,NS,carcinoma,adenocarcinoma c.2099A>G p.N700S 7:55173958-55173958 6
24 COSM86804352 EGFR ovary,NS,carcinoma,adenocarcinoma c.2123A>G p.K708R 7:55173982-55173982 6
25 COSM86808602 EGFR ovary,NS,carcinoma,adenocarcinoma c.2597A>G p.E866G 7:55191846-55191846 6
26 COSM86751503 EGFR ovary,NS,carcinoma,adenocarcinoma c.2494C>T p.R832C 7:55191743-55191743 6
27 COSM86769580 EGFR ovary,NS,carcinoma,adenocarcinoma c.2173A>G p.T725A 7:55174032-55174032 6
28 COSM86757992 EGFR ovary,NS,carcinoma,adenocarcinoma c.2108T>C p.L703P 7:55173967-55173967 6
29 COSM86757673 EGFR ovary,NS,carcinoma,adenocarcinoma c.2174C>T p.T725M 7:55174033-55174033 6
30 COSM86757974 EGFR ovary,NS,carcinoma,adenocarcinoma c.2159C>T p.S720F 7:55174018-55174018 6
31 COSM86770841 EGFR ovary,NS,carcinoma,adenocarcinoma c.2481C>T p.Y827= 7:55191730-55191730 6
32 COSM86748127 EGFR ovary,NS,carcinoma,adenocarcinoma c.2573T>G p.L858R 7:55191822-55191822 6
33 COSM86751403 EGFR ovary,NS,carcinoma,adenocarcinoma c.2161G>A p.G721S 7:55174020-55174020 6
34 COSM86757983 EGFR ovary,NS,carcinoma,adenocarcinoma c.2232C>A p.I744= 7:55174769-55174769 6
35 COSM86761167 EGFR ovary,NS,carcinoma,adenocarcinoma c.2506C>A p.R836S 7:55191755-55191755 6
36 COSM86751510 EGFR ovary,NS,carcinoma,adenocarcinoma c.2604A>T p.E868D 7:55191853-55191853 6
37 COSM86780270 EGFR ovary,NS,carcinoma,adenocarcinoma c.2112G>A p.L704= 7:55173971-55173971 6
38 COSM86767926 EGFR ovary,NS,carcinoma,adenocarcinoma c.2122A>G p.K708E 7:55173981-55173981 6
39 COSM86755734 EGFR ovary,NS,carcinoma,adenocarcinoma c.2559C>T p.I853= 7:55191808-55191808 6
40 COSM86770885 EGFR ovary,NS,carcinoma,adenocarcinoma c.2165C>T p.A722V 7:55174024-55174024 6
41 COSM86805588 EGFR ovary,NS,carcinoma,adenocarcinoma c.2556G>T p.K852N 7:55191805-55191805 6
42 COSM88138689 ATM ovary,NS,carcinoma,adenocarcinoma c.1810C>T p.P604S 11:108252824-108252824 6
43 COSM97820944 AR ovary,NS,carcinoma,adenocarcinoma c.2179C>T p.R727C 23:67717483-67717483 6
44 COSM133536287 AKT1 ovary,NS,carcinoma,adenocarcinoma c.235C>A p.Q79K 14:104776711-104776711 6
45 COSM148939078 ovary,NS,carcinoma,adenocarcinoma c.2725T>C p.F909L 3:179230062-179230062 6
46 COSM111761369 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 6
47 COSM142841902 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 6
48 COSM122736483 ovary,NS,carcinoma,adenocarcinoma c.-2A>G p.? 17:7675217-7675217 6
49 COSM147950776 ovary,NS,carcinoma,adenocarcinoma c.*163A>G p.? 7:55174032-55174032 6
50 COSM111980548 ovary,NS,carcinoma,adenocarcinoma c.2462A>G p.E821G 7:55191846-55191846 6

Expression for Krukenberg Carcinoma

Search GEO for disease gene expression data for Krukenberg Carcinoma.

Pathways for Krukenberg Carcinoma

Pathways related to Krukenberg Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.21 MUC1 CEACAM5

GO Terms for Krukenberg Carcinoma

Biological processes related to Krukenberg Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to organic substance GO:0071310 8.62 SYP SATB2

Sources for Krukenberg Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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