MCID: KRK001
MIFTS: 38

Krukenberg Carcinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Krukenberg Carcinoma

MalaCards integrated aliases for Krukenberg Carcinoma:

Name: Krukenberg Carcinoma 12 53 15
Krukenberg Tumor 12 53 44 17 72
Krukenberg Neoplasm 12
Krukenberg's Tumor 53

Classifications:



External Ids:

Disease Ontology 12 DOID:9597
MeSH 44 D007725
NCIt 50 C3153
SNOMED-CT 68 4305004 94455000
UMLS 72 C0022790

Summaries for Krukenberg Carcinoma

Disease Ontology : 12 An ovary epithelial cancer that is a metastatic signet-ring cell carcinoma, which spreads to the ovary from gastric tissue.

MalaCards based summary : Krukenberg Carcinoma, also known as krukenberg tumor, is related to dermoid cyst and cystic teratoma. An important gene associated with Krukenberg Carcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways are Hepatic ABC Transporters and Synaptic vesicle cycle. The drug Mitomycins has been mentioned in the context of this disorder. Affiliated tissues include ovary, breast and colon.

Wikipedia : 75 A Krukenberg tumor refers to a malignancy in the ovary that metastasized from a primary site,... more...

Related Diseases for Krukenberg Carcinoma

Diseases related to Krukenberg Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 dermoid cyst 30.3 NAPSA KRT7
2 cystic teratoma 30.2 SYP KRT7
3 cystadenoma 29.9 SYP KRT7
4 mucinous adenofibroma 29.9 SYP KRT7
5 teratoma 29.8 SYP KRT7
6 renal cell carcinoma, nonpapillary 29.4 NAPSA KRT7 HNF1B
7 ovarian mucinous neoplasm 29.2 SYP SATB2 KRT7
8 adenocarcinoma 10.6
9 gastric cancer 10.5
10 signet ring cell adenocarcinoma 10.5
11 gastric adenocarcinoma 10.4
12 cervical adenosquamous carcinoma 10.3 KRT7 HNF1B
13 ovary adenocarcinoma 10.2 KRT7 HNF1B
14 prostatic acinar adenocarcinoma 10.2 SATB2 KRT7
15 clear cell adenocarcinoma 10.2 KRT7 HNF1B
16 ovary epithelial cancer 10.2 KRT7 HNF1B
17 malignant ovarian surface epithelial-stromal neoplasm 10.2 KRT7 HNF1B
18 papillary adenoma 10.2 NAPSA KRT7
19 thymus adenocarcinoma 10.2 NAPSA KRT7
20 neurofibromatosis, type ii 10.2
21 microinvasive gastric cancer 10.2
22 gastric ulcer 10.2
23 myoma 10.2
24 gallbladder adenocarcinoma 10.2
25 adenocarcinoid tumor 10.2
26 goblet cell carcinoid 10.2
27 rare tumor 10.2
28 ovarian cancer 1 10.2 KRT7 HNF1B
29 polycystic liver disease 1 with or without kidney cysts 10.1 KRT7 HNF1B
30 cystadenocarcinoma 10.1
31 mucinous cystadenocarcinoma 10.1
32 ovarian cystadenocarcinoma 10.1
33 chromophobe renal cell carcinoma 10.1 KRT7 HNF1B
34 breast cancer 10.1
35 cholangiocarcinoma 10.1
36 pre-eclampsia 10.1
37 appendix cancer 10.1
38 cholestasis 10.1
39 amenorrhea 10.1
40 linitis plastica 10.1
41 intrahepatic cholangiocarcinoma 10.1
42 mature teratoma 10.1
43 peritonitis 10.1
44 appendiceal neoplasm 10.0
45 idiopathic interstitial pneumonia 10.0
46 gallbladder cancer 10.0
47 pulmonary fibrosis 10.0
48 tubular adenocarcinoma 10.0
49 peptic ulcer disease 10.0
50 ovary neuroendocrine neoplasm 10.0 SYP KRT7

Graphical network of the top 20 diseases related to Krukenberg Carcinoma:



Diseases related to Krukenberg Carcinoma

Symptoms & Phenotypes for Krukenberg Carcinoma

Drugs & Therapeutics for Krukenberg Carcinoma

Drugs for Krukenberg Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitomycins Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicentric Phase III Trial Comparing Simple Follow-up to Exploratory Laparotomy Plus "in Principle" HIPEC (Hyperthermic Intraperitoneal Chemotherapy) in Colorectal Patients Initially Treated With Surgery and Adjuvant Chemotherapy Who Have a High Risk of Developing Colorectal Peritoneal Carcinomatosis Unknown status NCT01226394 Phase 3
2 Randomized Multicentric Phase III Trial Comparing Simple Surgery to Surgery Plus HIPEC (Hyperthermic Intraperitoneal Chemotherapy) With MMC in Colorectal Patients Who Have a High Risk of Developing Colorectal Peritoneal Carcinomatosis Recruiting NCT02179489 Phase 3

Search NIH Clinical Center for Krukenberg Carcinoma

Cochrane evidence based reviews: krukenberg tumor

Genetic Tests for Krukenberg Carcinoma

Anatomical Context for Krukenberg Carcinoma

MalaCards organs/tissues related to Krukenberg Carcinoma:

41
Ovary, Breast, Colon, Appendix, Lung, Bone, Bone Marrow

Publications for Krukenberg Carcinoma

Articles related to Krukenberg Carcinoma:

(show top 50) (show all 291)
# Title Authors PMID Year
1
An Epithelioid Smooth Muscle Neoplasm Mimicking a Signet Ring Cell Carcinoma in the Ovary. 38
29750703 2019
2
Effects of metastasectomy and other factors on survival of patients with ovarian metastases from gastric cancer: a systematic review and meta-analysis. 38
31050365 2019
3
Treatments and overall survival in patients with Krukenberg tumor. 38
31044302 2019
4
Krukenberg Tumor Secondary to Lung Adenocarcinoma. 38
30545640 2019
5
[Diagnosis and treatment strategy of gastric cancer with ovarian metastasis]. 38
30917451 2019
6
Extensive Paneth cell metaplasia in an ovarian Krukenberg tumor: report of an unusual case and literature review. 38
30555671 2018
7
Measurable Krukenberg tumor is preferably characterized as a non-target lesion in the clinical evaluation of gastric cancer therapeutics: A case report. 38
30546891 2018
8
Ovarian Metastases of Breast Cancers With Signet Ring Cells: A Report of 17 Cases Including 14 Krukenberg Tumors. 38
29045292 2018
9
Glioblastoma metastatic to the ovary, a very different Krukenberg tumor? 38
29861347 2018
10
Torsion Ovary, an Unusual Presentation of Carcinoma Appendix Detected in Whole-Body F-18 2-Fluoro 2-deoxy Glucose Positron Emission Tomography/Computed Tomography Scan. 38
30386056 2018
11
Signet Ring Stromal Cell Tumor: A Legitimate (Benign) Mimic of Krukenberg Tumor. 38
30281366 2018
12
Malignant phyllodes tumor metastatic to bilateral ovaries: A Krukenberg-like presentation. 38
30197364 2018
13
[Clinicopathologic analysis of primary carcinoid of the ovary]. 38
29996316 2018
14
Signet Ring Cell Carcinoma of Unknown Primary Complicated with Pulmonary Tumor Thrombotic Microangiopathy and Krukenberg Tumor. 38
30057535 2018
15
Pressurized intraperitoneal aerosol chemotheprapy after misdiagnosed gastric cancer: Case report and review of the literature. 38
29785081 2018
16
A rare Krukenberg tumor arising from a primary adenocarcinoma of the small intestine. 38
29673681 2018
17
ERRATUM: Comparison of Surgery Plus Chemotherapy and Palliative Chemotherapy Alone for Advanced Gastric Cancer with Krukenberg Tumor. 38
29216420 2018
18
Is a Surgical Approach Justified in Metachronous Krukenberg Tumor from Gastric Cancer? A Systematic Review. 38
30205375 2018
19
PD-L1 Expression Predicts a Distinct Prognosis in Krukenberg Tumor with Corresponding Origins. 38
29854854 2018
20
Comparison of a Panel of Biomarkers Between Gastric Primary Cancer and the Paired Krukenberg Tumor. 38
26945444 2017
21
Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report. 38
28693131 2017
22
In utero virilization secondary to a maternal Krukenberg tumor: case report and review of literature. 38
28682787 2017
23
Synchronous hepatic metastasis and metachronous Krukenberg tumor from advanced colon cancer. A case report with an unexpected disease-free survival. 38
28012330 2017
24
Transcoelomic spread and ovarian seeding during ovulation: A possible pathogenesis of Krukenberg tumor. 38
28508852 2017
25
Bilateral Symmetrical Solid Ovarian Masses: Think Krukenberg Tumor. 38
27060533 2016
26
Feto-maternal outcomes of pregnancy complicated by Krukenberg tumor: a systematic review of literature. 38
26897498 2016
27
Misdiagnosed ovarian Krukenberg tumor during pregnancy with virilization. 38
29894093 2016
28
Exophthalmos Revealing a Krukenberg Tumor: A Case Presentation and Review of the Literature. 38
27721760 2016
29
Occult gastric cancer with distant metastasis proven by random gastric biopsy. 38
27122678 2016
30
Ovarian Tumors: Pattern of Histomorphological Types- A 10 Years Study in a Tertiary Referral Center and Review of Literature. 38
28166073 2016
31
Krukenberg Tumors of Gastric Origin: The Rationale of Surgical Resection and Perioperative Treatments in a Multicenter Western Experience. 38
26552908 2016
32
Postmenopausal vaginal bleeding as initial presentation of gastric cancer: a case report with literature review of prognostic factors and treatment of krukenberg tumor. 38
27004231 2016
33
Neuroendocrine Cancer of Rectum Metastasizing to Ovary. 38
27293931 2016
34
Sigmoid colonic metastasis by lymphatic spread occurring with unilateral Krukenberg tumor considered to be caused by stage IA early gastric cancer: A case report. 38
26870264 2016
35
Krukenberg tumor in a 18-year-old-female: a rare case. 38
27048128 2016
36
[Diagnostic value of combined detection of HNF-1β and Napsin A in the diagnosis of ovarian clear cell carcinoma]. 38
26888504 2015
37
Appendiceal mixed adenoneuroendocrine carcinomas, a rare entity that can present as a Krukenberg tumor: case report and review of the literature. 38
26612593 2015
38
Clinical characteristics and prognostic analysis of Krukenberg tumor. 38
26807242 2015
39
A 36-year-old female with Krukenberg tumor from a colonic carcinoma. 38
26881540 2015
40
Comparison of Surgery Plus Chemotherapy and Palliative Chemotherapy Alone for Advanced Gastric Cancer with Krukenberg Tumor. 38
25648093 2015
41
Krukenberg tumor presenting with amenorrhea as the sole initial symptom: Case report and review of the literature. 38
26881586 2015
42
Metastatic Ovarian Tumor Masquerading as Atypical Pneumonia. 38
26742194 2015
43
GAGE12 mediates human gastric carcinoma growth and metastasis. 38
25346337 2015
44
Isolated Krukenberg tumor in pregnancy. 38
25951735 2015
45
A 26-year-old female with metastatic primary gastrointestinal malignancy presenting as menorrhagia. 38
25830046 2015
46
Isolated gastric recurrence from ovarian carcinoma: A case report. 38
25663876 2015
47
Diagnostic value of dual detection of hepatocyte nuclear factor 1 beta (HNF-1β) and napsin A for diagnosing ovarian clear cell carcinoma. 38
26339401 2015
48
Krukenberg carcinoma metastasized from stomach resembling mucinous cystadenocarcinoma of the ovary. 38
26259386 2015
49
[Ascites and fever in women: do not rule out Krukenberg tumor]. 38
26587120 2015
50
Right cryptorchid testicular metastasis from descending colon carcinoma: a case report of "Krukenberg tumor" in male. 38
25337848 2015

Variations for Krukenberg Carcinoma

Cosmic variations for Krukenberg Carcinoma:

9 (show top 50) (show all 51)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10663 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 6
2 COSM10738 TP53 ovary,NS,carcinoma,adenocarcinoma c.542G>A p.R181H 17:7675070-7675070 6
3 COSM11148 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 6
4 COSM11582 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 6
5 COSM11066 TP53 ovary,NS,carcinoma,adenocarcinoma c.578A>T p.H193L 17:7674953-7674953 6
6 COSM6904336 TNFAIP3 ovary,NS,carcinoma,adenocarcinoma c.940G>A p.V314I 6:137877210-137877210 6
7 COSM14135 SMAD4 ovary,NS,carcinoma,adenocarcinoma c.1051G>C p.D351H 18:51065518-51065518 6
8 COSM6904335 SMAD2 ovary,NS,carcinoma,adenocarcinoma c.785-1G>C p.? 18:47848688-47848688 6
9 COSM6904334 RET ovary,NS,carcinoma,adenocarcinoma c.3253A>G p.T1085A 10:43128177-43128177 6
10 COSM6904339 PTCH1 ovary,NS,carcinoma,adenocarcinoma c.3074G>A p.R1025H 9:95458107-95458107 6
11 COSM94978 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.1034A>T p.N345I 3:179203764-179203764 6
12 COSM770 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.2725T>C p.F909L 3:179230062-179230062 6
13 COSM21446 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.3012G>T p.M1004I 3:179234169-179234169 6
14 COSM746 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.263G>A p.R88Q 3:179199088-179199088 6
15 COSM766 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.1636C>A p.Q546K 3:179218306-179218306 6
16 COSM580 NRAS ovary,NS,carcinoma,adenocarcinoma c.181C>A p.Q61K 1:114713909-114713909 6
17 COSM564 NRAS ovary,NS,carcinoma,adenocarcinoma c.35G>A p.G12D 1:114716126-114716126 6
18 COSM522 KRAS ovary,NS,carcinoma,adenocarcinoma c.35G>C p.G12A 12:25245350-25245350 6
19 COSM14065 ERBB2 ovary,NS,carcinoma,adenocarcinoma c.2524G>A p.V842I 17:39725079-39725079 6
20 COSM6224 EGFR ovary,NS,carcinoma,adenocarcinoma c.2573T>G p.L858R 7:55191822-55191822 6
21 COSM53230 EGFR ovary,NS,carcinoma,adenocarcinoma c.2597A>G p.E866G 7:55191846-55191846 6
22 COSM28511 EGFR ovary,NS,carcinoma,adenocarcinoma c.2108T>C p.L703P 7:55173967-55173967 6
23 COSM53225 EGFR ovary,NS,carcinoma,adenocarcinoma c.2112G>A p.L704L 7:55173971-55173971 6
24 COSM53232 EGFR ovary,NS,carcinoma,adenocarcinoma c.2122A>G p.K708E 7:55173981-55173981 6
25 COSM53226 EGFR ovary,NS,carcinoma,adenocarcinoma c.2099A>G p.N700S 7:55173958-55173958 6
26 COSM53224 EGFR ovary,NS,carcinoma,adenocarcinoma c.2173A>G p.T725A 7:55174032-55174032 6
27 COSM53229 EGFR ovary,NS,carcinoma,adenocarcinoma c.2232C>A p.I744I 7:55174769-55174769 6
28 COSM53231 EGFR ovary,NS,carcinoma,adenocarcinoma c.2559C>T p.I853I 7:55191808-55191808 6
29 COSM12373 EGFR ovary,NS,carcinoma,adenocarcinoma c.2159C>T p.S720F 7:55174018-55174018 6
30 COSM22992 EGFR ovary,NS,carcinoma,adenocarcinoma c.2161G>A p.G721S 7:55174020-55174020 6
31 COSM53264 EGFR ovary,NS,carcinoma,adenocarcinoma c.2174C>T p.T725M 7:55174033-55174033 6
32 COSM53228 EGFR ovary,NS,carcinoma,adenocarcinoma c.2123A>G p.K708R 7:55173982-55173982 6
33 COSM53227 EGFR ovary,NS,carcinoma,adenocarcinoma c.2506C>A p.R836S 7:55191755-55191755 6
34 COSM53235 EGFR ovary,NS,carcinoma,adenocarcinoma c.2481C>T p.Y827Y 7:55191730-55191730 6
35 COSM53265 EGFR ovary,NS,carcinoma,adenocarcinoma c.2556G>T p.K852N 7:55191805-55191805 6
36 COSM53213 EGFR ovary,NS,carcinoma,adenocarcinoma c.2604A>T p.E868D 7:55191853-55191853 6
37 COSM53266 EGFR ovary,NS,carcinoma,adenocarcinoma c.2165C>T p.A722V 7:55174024-55174024 6
38 COSM28286 EGFR ovary,NS,carcinoma,adenocarcinoma c.2494C>T p.R832C 7:55191743-55191743 6
39 COSM22499 ATM ovary,NS,carcinoma,adenocarcinoma c.1810C>T p.P604S 11:108252824-108252824 6
40 COSM6904304 AR ovary,NS,carcinoma,adenocarcinoma c.2179C>T p.R727C 23:67717483-67717483 6
41 COSM159008 AKT1 ovary,NS,carcinoma,adenocarcinoma c.235C>A p.Q79K 14:104776711-104776711 6
42 COSM760 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.1624G>A p.E542K 3:179218294-179218294 0
43 COSM763 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.1633G>A p.E545K 3:179218303-179218303 0
44 COSM776 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.3140A>T p.H1047L 3:179234297-179234297 0
45 COSM775 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.3140A>G p.H1047R 3:179234297-179234297 0
46 COSM521 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.35G>A p.G12D 12:25245350-25245350 0
47 COSM520 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.35G>T p.G12V 12:25245350-25245350 0
48 COSM517 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.34G>A p.G12S 12:25245351-25245351 0
49 COSM532 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.38G>A p.G13D 12:25245347-25245347 0
50 COSM518 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.34G>C p.G12R 12:25245351-25245351 0

Expression for Krukenberg Carcinoma

Search GEO for disease gene expression data for Krukenberg Carcinoma.

Pathways for Krukenberg Carcinoma

Pathways related to Krukenberg Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.25 HNF1B CACNA1B
2
Show member pathways
11.07 SYP CACNA1B
3
Show member pathways
10.61 HNF1B CACNA1B

GO Terms for Krukenberg Carcinoma

Biological processes related to Krukenberg Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to organic substance GO:0071310 8.62 SYP SATB2

Sources for Krukenberg Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....