MCID: KRK001
MIFTS: 32

Krukenberg Carcinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Krukenberg Carcinoma

MalaCards integrated aliases for Krukenberg Carcinoma:

Name: Krukenberg Carcinoma 12 53 15
Krukenberg Tumor 12 53 44 73
Krukenberg Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9597
MeSH 44 D007725
NCIt 50 C3153
SNOMED-CT 68 4305004 94455000
UMLS 73 C0022790

Summaries for Krukenberg Carcinoma

Disease Ontology : 12 An ovary epithelial cancer that is a metastatic signet-ring cell carcinoma, which spreads to the ovary from gastric tissue.

MalaCards based summary : Krukenberg Carcinoma, also known as krukenberg tumor, is related to mucinous cystadenocarcinoma and mucinous adenocarcinoma. An important gene associated with Krukenberg Carcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways are Hepatic ABC Transporters and Type II diabetes mellitus. The drugs Mitomycins and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, colon and appendix.

Wikipedia : 76 A Krukenberg tumor refers to a malignancy in the ovary that metastasized from a primary site,... more...

Related Diseases for Krukenberg Carcinoma

Diseases related to Krukenberg Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 mucinous cystadenocarcinoma 30.4 KRT20 KRT7
2 mucinous adenocarcinoma 30.3 KRT20 KRT7
3 ovarian cancer 1 30.1 HNF1B KRT7
4 transverse colon cancer 30.0 KRT20 KRT7
5 lung cancer susceptibility 3 29.7 KRT20 KRT7 NAPSA
6 gastric cancer 10.5
7 adenocarcinoma 10.4
8 papillary adenoma 10.2 KRT7 NAPSA
9 cystadenocarcinoma 10.1
10 cystic basal cell carcinoma 10.1 KRT20 KRT7
11 seminal vesicle adenocarcinoma 10.1 KRT20 KRT7
12 appendix adenocarcinoma 10.1 KRT20 KRT7
13 malignant syringoma 10.1 KRT20 KRT7
14 glandular cystitis 10.1 KRT20 KRT7
15 microinvasive gastric cancer 10.1
16 papillary transitional carcinoma 10.1 KRT20 KRT7
17 eyelid carcinoma 10.1 KRT20 KRT7
18 large intestine adenocarcinoma 10.1 KRT20 KRT7
19 linitis plastica 10.1 KRT20 KRT7
20 lung acinar adenocarcinoma 10.1 KRT20 KRT7
21 small cell carcinoma of the bladder 10.1 KRT20 KRT7
22 small cell carcinoma 10.1 KRT20 KRT7
23 adenoid squamous cell carcinoma 10.1 KRT20 KRT7
24 intratubular embryonal carcinoma 10.1 KRT20 KRT7
25 vulval paget's disease 10.1 KRT20 KRT7
26 bile duct cystadenocarcinoma 10.1 KRT20 KRT7
27 bile duct adenoma 10.1 KRT20 KRT7
28 jejunal adenocarcinoma 10.1 KRT20 KRT7
29 ovarian mucinous adenocarcinoma 10.1 KRT20 KRT7
30 appendix disease 10.1 KRT20 KRT7
31 gastric diffuse adenocarcinoma 10.1 KRT20 KRT7
32 meibomian cyst 10.1 KRT20 KRT7
33 bladder lymphoma 10.1 KRT20 KRT7
34 papillary serous adenocarcinoma 10.1 KRT20 KRT7
35 bladder adenocarcinoma 10.1 KRT20 KRT7
36 chronic cystitis 10.1 KRT20 KRT7
37 vulva adenocarcinoma 10.1 KRT20 KRT7
38 medulloepithelioma 10.1 KRT20 KRT7
39 glycogen-rich clear cell breast carcinoma 10.1 KRT20 KRT7
40 rectum adenocarcinoma 10.1 KRT20 KRT7
41 renal pelvis carcinoma 10.1 KRT20 KRT7
42 paget disease, extramammary 10.1 KRT20 KRT7
43 mucinous bronchioloalveolar adenocarcinoma 10.1 KRT20 KRT7
44 ampulla of vater adenocarcinoma 10.1 KRT20 KRT7
45 biliary papillomatosis 10.1 KRT20 KRT7
46 papilloma 10.1 KRT20 KRT7
47 lymphoepithelioma-like carcinoma 10.1 KRT20 KRT7
48 endocervical adenocarcinoma 10.1 KRT20 KRT7
49 cervical adenocarcinoma 10.1 KRT20 KRT7
50 eccrine sweat gland neoplasm 10.1 KRT20 KRT7

Graphical network of the top 20 diseases related to Krukenberg Carcinoma:



Diseases related to Krukenberg Carcinoma

Symptoms & Phenotypes for Krukenberg Carcinoma

Drugs & Therapeutics for Krukenberg Carcinoma

Drugs for Krukenberg Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitomycins Phase 3,Phase 1,Phase 2,Not Applicable
2
Cisplatin Approved Phase 1, Phase 2 15663-27-1 2767 441203 84093
3 Anti-Bacterial Agents Phase 1, Phase 2
4 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
5 Antibiotics, Antitubercular Phase 1, Phase 2
6 Alkylating Agents Phase 1, Phase 2
7 Cola Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Oophorectomy Followed by Chemotherapy Versus Chemotherapy Alone in Colorectal Cancer Patients Completed NCT01483443 Phase 3
2 Trial Comparing Simple Follow-up to Exploratory Laparotomy Plus "in Principle" (Hyperthermic Intraperitoneal Chemotherapy) HIPEC in Colorectal Patients Recruiting NCT01226394 Phase 3
3 Trial Evaluating Surgery With Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Treating Patients With a High Risk of Developing Colorectal Peritoneal Carcinomatosis Recruiting NCT02179489 Phase 3
4 Adjuvant HIPEC to Prevent Colorectal Peritoneal Metastases in High-risk Patients Completed NCT02575859 Phase 1, Phase 2 adjuvant HIPEC
5 Investigating Minimal Residual Disease in Autopreserved Ovarian Tissue in Cases of Neoplastic Pathology Unknown status NCT02888145
6 Prophylactic HIPEC for Colorectal Cancers at High Risk of Developing Peritoneal Metastases Recruiting NCT03422432 Not Applicable
7 Validation of a Method to Search Residual Disease in Auto-cryopreserved Ovarian Tissues Recruiting NCT02900625

Search NIH Clinical Center for Krukenberg Carcinoma

Cochrane evidence based reviews: krukenberg tumor

Genetic Tests for Krukenberg Carcinoma

Anatomical Context for Krukenberg Carcinoma

MalaCards organs/tissues related to Krukenberg Carcinoma:

41
Ovary, Colon, Appendix, Lung, Small Intestine, Kidney, Thymus

Publications for Krukenberg Carcinoma

Articles related to Krukenberg Carcinoma:

(show top 50) (show all 143)
# Title Authors Year
1
Krukenberg Tumor Secondary to Lung Adenocarcinoma. ( 30545640 )
2018
2
Measurable Krukenberg tumor is preferably characterized as a non-target lesion in the clinical evaluation of gastric cancer therapeutics: A case report. ( 30546891 )
2018
3
Is a Surgical Approach Justified in Metachronous Krukenberg Tumor from Gastric Cancer? A Systematic Review. ( 30205375 )
2018
4
Glioblastoma metastatic to the ovary, a very different Krukenberg tumor? ( 29861347 )
2018
5
ERRATUM: Comparison of Surgery Plus Chemotherapy and Palliative Chemotherapy Alone for Advanced Gastric Cancer with Krukenberg Tumor. ( 29216420 )
2018
6
A rare Krukenberg tumor arising from a primary adenocarcinoma of the small intestine. ( 29673681 )
2018
7
PD-L1 Expression Predicts a Distinct Prognosis in Krukenberg Tumor with Corresponding Origins. ( 29854854 )
2018
8
Signet Ring Cell Carcinoma of Unknown Primary Complicated with Pulmonary Tumor Thrombotic Microangiopathy and Krukenberg Tumor. ( 30057535 )
2018
9
Signet Ring Stromal Cell Tumor: A Legitimate (Benign) Mimic of Krukenberg Tumor. ( 30281366 )
2018
10
Extensive Paneth cell metaplasia in an ovarian Krukenberg tumor: report of an unusual case and literature review. ( 30555671 )
2018
11
Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report. ( 28693131 )
2017
12
Krukenberg carcinoma metastasized from stomach resembling mucinous cystadenocarcinoma of the ovary. ( 28976119 )
2017
13
Comparison of a Panel of Biomarkers Between Gastric Primary Cancer and the Paired Krukenberg Tumor. ( 26945444 )
2017
14
Synchronous hepatic metastasis and metachronous Krukenberg tumor from advanced colon cancer. A case report with an unexpected disease-free survival. ( 28012330 )
2017
15
Transcoelomic spread and ovarian seeding during ovulation: A possible pathogenesis of Krukenberg tumor. ( 28508852 )
2017
16
In utero virilization secondary to a maternal Krukenberg tumor: case report and review of literature. ( 28682787 )
2017
17
Exophthalmos Revealing a Krukenberg Tumor: A Case Presentation and Review of the Literature. ( 27721760 )
2016
18
Sigmoid colonic metastasis by lymphatic spread occurring with unilateral Krukenberg tumor considered to be caused by stage IA early gastric cancer: A case report. ( 26870264 )
2016
19
Feto-maternal outcomes of pregnancy complicated by Krukenberg tumor: a systematic review of literature. ( 26897498 )
2016
20
Postmenopausal vaginal bleeding as initial presentation of gastric cancer: a case report with literature review of prognostic factors and treatment of krukenberg tumor. ( 27004231 )
2016
21
Krukenberg tumor in a 18-year-old-female: a rare case. ( 27048128 )
2016
22
Bilateral Symmetrical Solid Ovarian Masses: Think Krukenberg Tumor. ( 27060533 )
2016
23
Misdiagnosed ovarian Krukenberg tumor during pregnancy with virilization. ( 29894093 )
2016
24
Krukenberg tumor presenting with amenorrhea as the sole initial symptom: Case report and review of the literature. ( 26881586 )
2015
25
Krukenberg carcinoma metastasized from stomach resembling mucinous cystadenocarcinoma of the ovary. ( 26259386 )
2015
26
Right cryptorchid testicular metastasis from descending colon carcinoma: a case report of "Krukenberg tumor" in male. ( 25337848 )
2015
27
Comparison of Surgery Plus Chemotherapy and Palliative Chemotherapy Alone for Advanced Gastric Cancer with Krukenberg Tumor. ( 25648093 )
2015
28
Isolated Krukenberg tumor in pregnancy. ( 25951735 )
2015
29
Appendiceal mixed adenoneuroendocrine carcinomas, a rare entity that can present as a Krukenberg tumor: case report and review of the literature. ( 26612593 )
2015
30
Clinical characteristics and prognostic analysis of Krukenberg tumor. ( 26807242 )
2015
31
A 36-year-old female with Krukenberg tumor from a colonic carcinoma. ( 26881540 )
2015
32
Krukenberg tumor secondary to an incidentally discovered gall bladder carcinoma: a rare occurrence. ( 25368464 )
2014
33
Krukenberg tumor presenting as back pain and a positive urine pregnancy test: a case report and literature review. ( 24708577 )
2014
34
Krukenberg tumor in a pregnant patient with severe preeclampsia. ( 24926329 )
2014
35
Giant Krukenberg tumor from a perforated gastric cancer that was successfully removed after multidisciplinary therapy: report of a case. ( 22987279 )
2014
36
A case of colon cancer with breast metastasis and krukenberg tumor. ( 24505551 )
2014
37
Bilateral Krukenberg tumor in a 16-week pregnant woman. ( 24654473 )
2014
38
Krukenberg tumor in a young woman: a rare presentation. ( 24739850 )
2014
39
Pregnancy complicated by a Krukenberg tumor with an undetermined origin and its management. ( 25181628 )
2014
40
A Krukenberg Tumor from an Occult Intramucosal Gastric Carcinoma Identified during an Autopsy. ( 25386374 )
2014
41
A curious discourse of Krukenberg tumor: a case report. ( 25436134 )
2014
42
Gastric cancer presenting as a krukenberg tumor at 22 weeks' gestation. ( 25580361 )
2014
43
Krukenberg tumor after gastric bypass for morbid obesity. Bariatric surgery and gastric cancer. ( 23971662 )
2013
44
A case of Krukenberg carcinoma metastasized from colon cancer resembling mucinous cystadenocarcinoma of the ovary. ( 24427362 )
2013
45
Surgical treatment for patients with Krukenberg tumor of stomach origin: clinical outcome and prognostic factors analysis. ( 23874550 )
2013
46
Role of ultrasonography and contrast-enhanced ultrasonography in a case of Krukenberg tumor. ( 24003358 )
2013
47
Intralesional hemorrhage in Krukenberg tumor: a case report and review of the literature. ( 24294349 )
2013
48
Isolated ovarian metastasis of gastric cancer: Krukenberg tumor. ( 24592139 )
2013
49
Excessive hirsutism in pregnancy because of Krukenberg tumor. ( 21838532 )
2012
50
Krukenberg tumor: a rare cause of ovarian torsion. ( 22439130 )
2012

Variations for Krukenberg Carcinoma

Cosmic variations for Krukenberg Carcinoma:

9 (show top 50) (show all 51)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10663 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 8
2 COSM11066 TP53 ovary,NS,carcinoma,adenocarcinoma c.578A>T p.H193L 17:7674953-7674953 8
3 COSM10738 TP53 ovary,NS,carcinoma,adenocarcinoma c.542G>A p.R181H 17:7675070-7675070 8
4 COSM11148 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 8
5 COSM11582 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 8
6 COSM6904336 TNFAIP3 ovary,NS,carcinoma,adenocarcinoma c.940G>A p.V314I 6:137877210-137877210 8
7 COSM14135 SMAD4 ovary,NS,carcinoma,adenocarcinoma c.1051G>C p.D351H 18:51065518-51065518 8
8 COSM6904335 SMAD2 ovary,NS,carcinoma,adenocarcinoma c.785-1G>C p.? 18:47848688-47848688 8
9 COSM6904334 RET ovary,NS,carcinoma,adenocarcinoma c.3253A>G p.T1085A 10:43128177-43128177 8
10 COSM6904339 PTCH1 ovary,NS,carcinoma,adenocarcinoma c.3074G>A p.R1025H 9:95458107-95458107 8
11 COSM770 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.2725T>C p.F909L 3:179230062-179230062 8
12 COSM21446 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.3012G>T p.M1004I 3:179234169-179234169 8
13 COSM746 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.263G>A p.R88Q 3:179199088-179199088 8
14 COSM94978 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.1034A>T p.N345I 3:179203764-179203764 8
15 COSM766 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.1636C>A p.Q546K 3:179218306-179218306 8
16 COSM564 NRAS ovary,NS,carcinoma,adenocarcinoma c.35G>A p.G12D 1:114716126-114716126 8
17 COSM580 NRAS ovary,NS,carcinoma,adenocarcinoma c.181C>A p.Q61K 1:114713909-114713909 8
18 COSM522 KRAS ovary,NS,carcinoma,adenocarcinoma c.35G>C p.G12A 12:25245350-25245350 8
19 COSM14065 ERBB2 ovary,NS,carcinoma,adenocarcinoma c.2524G>A p.V842I 17:39725079-39725079 8
20 COSM22992 EGFR ovary,NS,carcinoma,adenocarcinoma c.2161G>A p.G721S 7:55174020-55174020 8
21 COSM53264 EGFR ovary,NS,carcinoma,adenocarcinoma c.2174C>T p.T725M 7:55174033-55174033 8
22 COSM6224 EGFR ovary,NS,carcinoma,adenocarcinoma c.2573T>G p.L858R 7:55191822-55191822 8
23 COSM53230 EGFR ovary,NS,carcinoma,adenocarcinoma c.2597A>G p.E866G 7:55191846-55191846 8
24 COSM28511 EGFR ovary,NS,carcinoma,adenocarcinoma c.2108T>C p.L703P 7:55173967-55173967 8
25 COSM53225 EGFR ovary,NS,carcinoma,adenocarcinoma c.2112G>A p.L704L 7:55173971-55173971 8
26 COSM53232 EGFR ovary,NS,carcinoma,adenocarcinoma c.2122A>G p.K708E 7:55173981-55173981 8
27 COSM53226 EGFR ovary,NS,carcinoma,adenocarcinoma c.2099A>G p.N700S 7:55173958-55173958 8
28 COSM53266 EGFR ovary,NS,carcinoma,adenocarcinoma c.2165C>T p.A722V 7:55174024-55174024 8
29 COSM53224 EGFR ovary,NS,carcinoma,adenocarcinoma c.2173A>G p.T725A 7:55174032-55174032 8
30 COSM53213 EGFR ovary,NS,carcinoma,adenocarcinoma c.2604A>T p.E868D 7:55191853-55191853 8
31 COSM53229 EGFR ovary,NS,carcinoma,adenocarcinoma c.2232C>A p.I744I 7:55174769-55174769 8
32 COSM53231 EGFR ovary,NS,carcinoma,adenocarcinoma c.2559C>T p.I853I 7:55191808-55191808 8
33 COSM12373 EGFR ovary,NS,carcinoma,adenocarcinoma c.2159C>T p.S720F 7:55174018-55174018 8
34 COSM53265 EGFR ovary,NS,carcinoma,adenocarcinoma c.2556G>T p.K852N 7:55191805-55191805 8
35 COSM53235 EGFR ovary,NS,carcinoma,adenocarcinoma c.2481C>T p.Y827Y 7:55191730-55191730 8
36 COSM28286 EGFR ovary,NS,carcinoma,adenocarcinoma c.2494C>T p.R832C 7:55191743-55191743 8
37 COSM53228 EGFR ovary,NS,carcinoma,adenocarcinoma c.2123A>G p.K708R 7:55173982-55173982 8
38 COSM53227 EGFR ovary,NS,carcinoma,adenocarcinoma c.2506C>A p.R836S 7:55191755-55191755 8
39 COSM22499 ATM ovary,NS,carcinoma,adenocarcinoma c.1810C>T p.P604S 11:108252824-108252824 8
40 COSM6904304 AR ovary,NS,carcinoma,adenocarcinoma c.2179C>T p.R727C 23:67717483-67717483 8
41 COSM159008 AKT1 ovary,NS,carcinoma,adenocarcinoma c.235C>A p.Q79K 14:104776711-104776711 8
42 COSM760 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.1624G>A p.E542K 3:179218294-179218294 6
43 COSM775 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.3140A>G p.H1047R 3:179234297-179234297 6
44 COSM776 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.3140A>T p.H1047L 3:179234297-179234297 6
45 COSM763 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.1633G>A p.E545K 3:179218303-179218303 6
46 COSM521 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.35G>A p.G12D 12:25245350-25245350 6
47 COSM520 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.35G>T p.G12V 12:25245350-25245350 6
48 COSM517 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.34G>A p.G12S 12:25245351-25245351 6
49 COSM532 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.38G>A p.G13D 12:25245347-25245347 6
50 COSM518 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.34G>C p.G12R 12:25245351-25245351 6

Expression for Krukenberg Carcinoma

Search GEO for disease gene expression data for Krukenberg Carcinoma.

Pathways for Krukenberg Carcinoma

Pathways related to Krukenberg Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.05 CACNA1B HNF1B
2
Show member pathways
10.61 CACNA1B HNF1B

GO Terms for Krukenberg Carcinoma

Biological processes related to Krukenberg Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 8.62 KRT20 KRT7

Sources for Krukenberg Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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