MCID: KMM001
MIFTS: 28

Kummell's Disease

Categories: Bone diseases

Aliases & Classifications for Kummell's Disease

MalaCards integrated aliases for Kummell's Disease:

Name: Kummell's Disease 12 15
Traumatic Spondylopathy 12 74
Kummell's Spondylitis 12
Kummell Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6603
ICD9CM 36 721.7
SNOMED-CT 69 65753008
ICD10 34 M48.3
UMLS 74 C0152088

Summaries for Kummell's Disease

MalaCards based summary : Kummell's Disease, also known as traumatic spondylopathy, is related to osteonecrosis and osteoporosis. An important gene associated with Kummell's Disease is TBX1 (T-Box 1), and among its related pathways/superpathways are Differentiation Pathway and Transcription_Role of VDR in regulation of genes involved in osteoporosis. Affiliated tissues include bone, and related phenotypes are growth/size/body region and craniofacial

Related Diseases for Kummell's Disease

Diseases related to Kummell's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis 29.9 TNFRSF11B TNFSF11
2 osteoporosis 29.0 DKK1 SOST TNFRSF11B TNFSF11
3 osteoporosis, juvenile 10.0 DKK1 SOST
4 renal osteodystrophy 10.0 SOST TNFRSF11B
5 hyperostosis 9.9 SOST TNFRSF11B
6 osteopetrosis, autosomal dominant 2 9.8 SOST TNFSF11
7 polyarticular onset juvenile idiopathic arthritis 9.8 TNFRSF11B TNFSF11
8 hemophilic arthropathy 9.8 TNFRSF11B TNFSF11
9 joint disorders 9.8 DKK1 TNFSF11
10 arthropathy 9.8 TNFRSF11B TNFSF11
11 multicentric reticulohistiocytosis 9.8 TNFRSF11B TNFSF11
12 paget disease of bone 5, juvenile-onset 9.8 TNFRSF11B TNFSF11
13 periodontitis, chronic 9.8 TNFRSF11B TNFSF11
14 periodontitis 9.8 TNFRSF11B TNFSF11
15 chronic apical periodontitis 9.8 TNFRSF11B TNFSF11
16 familial expansile osteolysis 9.8 TNFRSF11B TNFSF11
17 multicentric carpotarsal osteolysis syndrome 9.8 TNFRSF11B TNFSF11
18 periapical periodontitis 9.8 TNFRSF11B TNFSF11
19 tooth resorption 9.8 TNFRSF11B TNFSF11
20 root resorption 9.8 TNFRSF11B TNFSF11
21 endosteal hyperostosis, autosomal dominant 9.7 TNFRSF11B TNFSF11
22 paget's disease of bone 9.7 TNFRSF11B TNFSF11
23 bone inflammation disease 9.7 TNFRSF11B TNFSF11
24 aortic valve disease 2 9.6 TNFRSF11B TNFSF11
25 ischemic bone disease 9.6 SOST TNFRSF11B TNFSF11
26 bone remodeling disease 9.6 SOST TNFRSF11B TNFSF11
27 giant cell tumor 9.6 TNFRSF11B TNFSF11
28 glucocorticoid-induced osteoporosis 9.5 DKK1 TNFRSF11B TNFSF11
29 myeloma, multiple 9.5 DKK1 TNFRSF11B TNFSF11
30 synovitis 9.4 TNFRSF11B TNFSF11
31 bone resorption disease 9.3 DKK1 SOST TNFRSF11B TNFSF11
32 bone disease 9.3 DKK1 SOST TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Kummell's Disease:



Diseases related to Kummell's Disease

Symptoms & Phenotypes for Kummell's Disease

MGI Mouse Phenotypes related to Kummell's Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.63 DKK1 PLK2 SOST TBX1 TNFRSF11B TNFSF11
2 craniofacial MP:0005382 9.56 DKK1 TBX1 TNFRSF11B TNFSF11
3 limbs/digits/tail MP:0005371 9.35 DKK1 SOST TBX1 TNFRSF11B TNFSF11
4 skeleton MP:0005390 9.1 DKK1 PLK2 SOST TBX1 TNFRSF11B TNFSF11

Drugs & Therapeutics for Kummell's Disease

Search Clinical Trials , NIH Clinical Center for Kummell's Disease

Genetic Tests for Kummell's Disease

Anatomical Context for Kummell's Disease

MalaCards organs/tissues related to Kummell's Disease:

42
Bone

Publications for Kummell's Disease

Articles related to Kummell's Disease:

(show all 16)
# Title Authors Year
1
Posttraumatic Delayed Vertebral Collapse : Kummell's Disease. ( 29354230 )
2018
2
Case report of Kummell's disease with delayed onset myelopathy and the literature review. ( 28913640 )
2017
3
Failed Percutaneous Vertebroplasty Due to Insufficient Correction of Intravertebral Instability in Kummell's Disease: A Case Report. ( 28160398 )
2017
4
Bone Cement-Augmented Percutaneous Short Segment Fixation: An Effective Treatment for Kummell's Disease? ( 26279814 )
2015
5
Spontaneous air reduction of vertebra plana with Kummell's disease during vertebroplasty: subsequent experience with an intentional trial. ( 24716992 )
2014
6
Cannula-induced Vertebral Reduction during Kyphoplasty in a Patient with Kummell's Disease. ( 22514785 )
2012
7
A case of posterior element fracture in Kummell's disease. ( 21811863 )
2012
8
Chronic Spinal Epidural Hematoma Related to Kummell's Disease. ( 21607183 )
2011
9
Cement augmented anterior reconstruction with short posterior instrumentation: a less invasive surgical option for Kummell's disease with cord compression. ( 21315603 )
2011
10
Spontaneous Vertebral Reduction during the Procedure of Kyphoplasty in a Patient with Kummell's Disease. ( 22220246 )
2011
11
Kummell's disease: delayed post-traumatic osteonecrosis of the vertebral body. ( 19949820 )
2010
12
Percutaneous vertebroplasty as treatment for Kummell's disease. ( 19534241 )
2009
13
Delayed post-traumatic osteonecrosis of a vertebral body (Kummell's disease). ( 11915453 )
2002
14
From surgical imaging...standard and fluoroscopic radiographs demonstrate the instability of thoracic compression fractures and the confluence of findings in fractures resulting from osteoporosis and those resulting from Kummell's disease. ( 14598806 )
2002
15
Delayed post-traumatic vertebral collapse (Kummell's disease): case report with serial radiographs, computed tomographic scans, and bone scans. ( 8362333 )
1993
16
KUMMELL'S DISEASE. ( 20775217 )
1930

Variations for Kummell's Disease

Expression for Kummell's Disease

Search GEO for disease gene expression data for Kummell's Disease.

Pathways for Kummell's Disease

GO Terms for Kummell's Disease

Cellular components related to Kummell's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 DKK1 EPHA3 SOST TNFRSF11B TNFSF11

Biological processes related to Kummell's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.54 DKK1 TNFRSF11B TNFSF11
2 ossification GO:0001503 9.4 SOST TNFSF11
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.32 TNFRSF11B TNFSF11
4 cellular response to retinoic acid GO:0071300 9.26 EPHA3 TBX1
5 negative regulation of BMP signaling pathway GO:0030514 9.16 DKK1 SOST
6 face morphogenesis GO:0060325 8.96 DKK1 TBX1
7 negative regulation of ossification GO:0030279 8.62 DKK1 SOST

Sources for Kummell's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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