MCID: KMM001
MIFTS: 22

Kummell's Disease

Categories: Bone diseases

Aliases & Classifications for Kummell's Disease

MalaCards integrated aliases for Kummell's Disease:

Name: Kummell's Disease 12 15
Traumatic Spondylopathy 12 70 32
Kummell's Spondylitis 12
Kummell Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6603
ICD9CM 34 721.7
SNOMED-CT 67 240218006
ICD10 32 M48.3
UMLS 70 C0152088

Summaries for Kummell's Disease

MalaCards based summary : Kummell's Disease, also known as traumatic spondylopathy, is related to osteonecrosis and spondylitis. An important gene associated with Kummell's Disease is VWA2 (Von Willebrand Factor A Domain Containing 2), and among its related pathways/superpathways are Differentiation Pathway and Transcription_Role of VDR in regulation of genes involved in osteoporosis.

Related Diseases for Kummell's Disease

Diseases related to Kummell's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis 29.9 TNFSF11 DKK1
2 spondylitis 29.4 TNFSF11 SOST DKK1
3 osteoporosis 28.9 TNFSF11 SOST DKK1 CALCA
4 avascular necrosis 10.2
5 spinal disease 10.1
6 inflammatory spondylopathy 10.1
7 exostosis 10.0 SOST CALCA
8 spinal stenosis 10.0
9 pulmonary embolism 10.0
10 paresthesia 10.0
11 cerebrotendinous xanthomatosis 10.0 CYP27A1 CALCA
12 bone mineral density quantitative trait locus 8 10.0
13 bone mineral density quantitative trait locus 15 10.0
14 back pain 10.0
15 sclerosteosis 1 10.0 SOST DKK1
16 craniodiaphyseal dysplasia 10.0 SOST DKK1
17 osteoporosis-pseudoglioma syndrome 9.9 SOST DKK1
18 pycnodysostosis 9.8 TNFSF11 SOST
19 malignant ovarian brenner tumor 9.8 TNFSF11 CALCA
20 paget disease of bone 5, juvenile-onset 9.8 TNFSF11 CALCA
21 gorham's disease 9.8 TNFSF11 CALCA
22 aneurysmal bone cysts 9.8 TNFSF11 CALCA
23 giant cell reparative granuloma 9.8 TNFSF11 CALCA
24 tooth resorption 9.8 TNFSF11 CALCA
25 bone benign neoplasm 9.8 TNFSF11 CALCA
26 craniometaphyseal dysplasia, autosomal dominant 9.8 TNFSF11 SOST
27 bone giant cell tumor 9.8 TNFSF11 CALCA
28 root resorption 9.8 TNFSF11 CALCA
29 benign giant cell tumor 9.8 TNFSF11 CALCA
30 mammary paget's disease 9.8 TNFSF11 CALCA
31 fibrous dysplasia 9.8 TNFSF11 CALCA
32 ankylosis 9.7 TNFSF11 SOST
33 cherubism 9.7 TNFSF11 CALCA
34 mineral metabolism disease 9.7 TNFSF11 CALCA
35 osteomyelitis 9.7 TNFSF11 CALCA
36 spondyloarthropathy 9.6 TNFSF11 CALCA
37 endosteal hyperostosis, autosomal dominant 9.6 TNFSF11 SOST
38 renal osteodystrophy 9.6 TNFSF11 SOST CALCA
39 parathyroid gland disease 9.6 TNFSF11 SOST CALCA
40 primary hyperparathyroidism 9.6 TNFSF11 SOST CALCA
41 van buchem disease 9.6 TNFSF11 SOST DKK1
42 sclerosteosis 9.5 TNFSF11 SOST DKK1
43 glucocorticoid-induced osteoporosis 9.5 TNFSF11 DKK1 CALCA
44 ischemic bone disease 9.3 TNFSF11 SOST DKK1 CALCA
45 bone disease 9.3 TNFSF11 SOST DKK1 CALCA
46 osteoporosis, juvenile 9.3 TNFSF11 SOST DKK1 CALCA
47 paget's disease of bone 9.3 TNFSF11 SOST DKK1 CALCA
48 brittle bone disorder 9.3 TNFSF11 SOST DKK1 CALCA
49 odontochondrodysplasia 9.3 TNFSF11 SOST DKK1 CALCA
50 connective tissue disease 9.2 TNFSF11 SOST CALCA

Graphical network of the top 20 diseases related to Kummell's Disease:



Diseases related to Kummell's Disease

Symptoms & Phenotypes for Kummell's Disease

Drugs & Therapeutics for Kummell's Disease

Search Clinical Trials , NIH Clinical Center for Kummell's Disease

Genetic Tests for Kummell's Disease

Anatomical Context for Kummell's Disease

Publications for Kummell's Disease

Articles related to Kummell's Disease:

(show all 29)
# Title Authors PMID Year
1
The clinical results of treating Kummell's disease with mineralized collagen modified polymethyl methacrylate. 61
33554721 2021
2
Perioperative Hidden Blood Loss in Elderly Osteoporotic Vertebral Compression Fracture Patients With Percutaneous Vertebroplasty and Influencing Factors. 61
33708455 2021
3
Pediculoplasty combined with vertebroplasty for the treatment of Kummell's disease without neurological impairment: robot-assisted and fluoroscopy-guided. 61
33437377 2020
4
Acute burst fracture in Kummell's disease with acute onset neurological deficit: a case report on role of spinal stability and technical notes on "pivot ligamentotaxis". 61
31088435 2019
5
Anterior reconstruction versus posterior osteotomy in treating Kümmell's disease with neurological deficits: A systematic review. 61
29803679 2018
6
Case report of Kummell's disease with delayed onset myelopathy and the literature review. 61
28913640 2018
7
Posttraumatic Delayed Vertebral Collapse : Kummell's Disease. 61
29354230 2018
8
Failed Percutaneous Vertebroplasty Due to Insufficient Correction of Intravertebral Instability in Kummell's Disease: A Case Report. 61
28160398 2017
9
Nomogram for Predicting Intradiscal Cement Leakage Following Percutaneous Vertebroplasty in Patients with Osteoporotic Related Vertebral Compression Fractures. 61
28535560 2017
10
[Diagnostic analysis of the radiologic characteristics in osteoporotic Kiinmmel's disease]. 61
27505965 2016
11
Percutaneous Kyphoplasty for Kummell Disease with Severe Spinal Canal Stenosis. 61
26606016 2015
12
[GRADED INFUSION OF BONE CEMENT IN PERCUTANEOUS VERTEBROPLASTY FOR Kummell's DISEASE]. 61
26749736 2015
13
Bone Cement-Augmented Percutaneous Short Segment Fixation: An Effective Treatment for Kummell's Disease? 61
26279814 2015
14
[Clinical efficacy of unipedicular versus bipedicular percutaneous vertebroplasty for Kummell's disease]. 61
25263378 2014
15
Spontaneous air reduction of vertebra plana with Kummell's disease during vertebroplasty: subsequent experience with an intentional trial. 61
24716992 2014
16
Pathomechanism of intravertebral clefts in osteoporotic compression fractures of the spine. 61
24055039 2014
17
[Balloon kyphoplasty for the treatment of osteoporotic Kummell's disease]. 61
23937040 2013
18
A case of posterior element fracture in Kummell's disease. 61
21811863 2012
19
Cannula-induced Vertebral Reduction during Kyphoplasty in a Patient with Kummell's Disease. 61
22514785 2012
20
Spontaneous Vertebral Reduction during the Procedure of Kyphoplasty in a Patient with Kummell's Disease. 61
22220246 2011
21
Chronic Spinal Epidural Hematoma Related to Kummell's Disease. 61
21607183 2011
22
Cement augmented anterior reconstruction with short posterior instrumentation: a less invasive surgical option for Kummell's disease with cord compression. 61
21315603 2011
23
Kummell's disease: delayed post-traumatic osteonecrosis of the vertebral body. 61
19949820 2010
24
Percutaneous vertebroplasty as treatment for Kummell's disease. 61
19534241 2009
25
Delayed posttraumatic vertebral collapse with intravertebral vacuum cleft. 61
12021746 2002
26
Delayed post-traumatic osteonecrosis of a vertebral body (Kummell's disease). 61
11915453 2002
27
From surgical imaging...standard and fluoroscopic radiographs demonstrate the instability of thoracic compression fractures and the confluence of findings in fractures resulting from osteoporosis and those resulting from Kummell's disease. 61
14598806 2002
28
Delayed post-traumatic vertebral collapse (Kummell's disease): case report with serial radiographs, computed tomographic scans, and bone scans. 61
8362333 1993
29
KUMMELL'S DISEASE. 61
20775217 1930

Variations for Kummell's Disease

Expression for Kummell's Disease

Search GEO for disease gene expression data for Kummell's Disease.

Pathways for Kummell's Disease

Pathways related to Kummell's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.84 TNFSF11 DKK1
2 10.61 TNFSF11 CALCA
3
Show member pathways
9.95 SOST DKK1

GO Terms for Kummell's Disease

Cellular components related to Kummell's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 VWA2 VWA1 TNFSF11 SOST DKK1 CALCA
2 collagen-containing extracellular matrix GO:0062023 9.33 VWA2 VWA1 SOST
3 basement membrane GO:0005604 9.26 VWA2 VWA1
4 extracellular space GO:0005615 9.1 VWA2 VWA1 TNFSF11 SOST DKK1 CALCA

Biological processes related to Kummell's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of Wnt signaling pathway GO:0030178 9.16 SOST DKK1
2 monocyte chemotaxis GO:0002548 8.96 TNFSF11 CALCA
3 negative regulation of ossification GO:0030279 8.8 SOST DKK1 CALCA

Sources for Kummell's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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