MCID: KMM001
MIFTS: 28

Kummell's Disease

Categories: Bone diseases

Aliases & Classifications for Kummell's Disease

MalaCards integrated aliases for Kummell's Disease:

Name: Kummell's Disease 12 15
Traumatic Spondylopathy 12 73
Kummell's Spondylitis 12
Kummell Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6603
ICD10 33 M48.3
ICD9CM 35 721.7
UMLS 73 C0152088

Summaries for Kummell's Disease

MalaCards based summary : Kummell's Disease, also known as traumatic spondylopathy, is related to renal osteodystrophy and hyperostosis. An important gene associated with Kummell's Disease is EPHA3 (EPH Receptor A3), and among its related pathways/superpathways are Parathyroid hormone synthesis, secretion and action and Differentiation Pathway. Affiliated tissues include bone, and related phenotypes are limbs/digits/tail and skeleton

Related Diseases for Kummell's Disease

Diseases related to Kummell's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 renal osteodystrophy 10.0 SOST TNFRSF11B
2 hyperostosis 9.9 SOST TNFRSF11B
3 osteogenesis imperfecta, type vi 9.7 SOST TNFSF11
4 joint disorders 9.7 DKK1 TNFSF11
5 polyarticular onset juvenile idiopathic arthritis 9.7 TNFRSF11B TNFSF11
6 hemophilic arthropathy 9.7 TNFRSF11B TNFSF11
7 multicentric reticulohistiocytosis 9.7 TNFRSF11B TNFSF11
8 paget disease of bone 5, juvenile-onset 9.7 TNFRSF11B TNFSF11
9 periodontitis, chronic 9.7 TNFRSF11B TNFSF11
10 chronic apical periodontitis 9.6 TNFRSF11B TNFSF11
11 familial expansile osteolysis 9.6 TNFRSF11B TNFSF11
12 multicentric carpotarsal osteolysis syndrome 9.6 TNFRSF11B TNFSF11
13 periapical periodontitis 9.6 TNFRSF11B TNFSF11
14 tooth resorption 9.6 TNFRSF11B TNFSF11
15 ischemic bone disease 9.6 TNFRSF11B TNFSF11
16 root resorption 9.6 TNFRSF11B TNFSF11
17 endosteal hyperostosis, autosomal dominant 9.5 TNFRSF11B TNFSF11
18 osteonecrosis 9.5 TNFRSF11B TNFSF11
19 giant cell tumor 9.5 TNFRSF11B TNFSF11
20 bone inflammation disease 9.4 TNFRSF11B TNFSF11
21 paget's disease of bone 9.4 TNFRSF11B TNFSF11
22 aortic valve disease 2 9.4 TNFRSF11B TNFSF11
23 synovitis 9.3 TNFRSF11B TNFSF11
24 arthropathy 9.2 TNFRSF11B TNFSF11
25 bone remodeling disease 9.1 SOST TNFRSF11B TNFSF11
26 periodontitis 9.1 TNFRSF11B TNFSF11
27 glucocorticoid-induced osteoporosis 9.1 DKK1 TNFRSF11B TNFSF11
28 myeloma, multiple 9.0 DKK1 TNFRSF11B TNFSF11
29 periodontal disease 8.9 TNFRSF11B TNFSF11
30 bone resorption disease 8.5 DKK1 SOST TNFRSF11B TNFSF11
31 bone disease 8.5 DKK1 SOST TNFRSF11B TNFSF11
32 osteoporosis 8.5 DKK1 SOST TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Kummell's Disease:



Diseases related to Kummell's Disease

Symptoms & Phenotypes for Kummell's Disease

MGI Mouse Phenotypes related to Kummell's Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.26 DKK1 SOST TNFRSF11B TNFSF11
2 skeleton MP:0005390 9.02 DKK1 PLK2 SOST TNFRSF11B TNFSF11

Drugs & Therapeutics for Kummell's Disease

Search Clinical Trials , NIH Clinical Center for Kummell's Disease

Genetic Tests for Kummell's Disease

Anatomical Context for Kummell's Disease

MalaCards organs/tissues related to Kummell's Disease:

41
Bone

Publications for Kummell's Disease

Articles related to Kummell's Disease:

(show all 16)
# Title Authors Year
1
Posttraumatic Delayed Vertebral Collapse : Kummell's Disease. ( 29354230 )
2018
2
Case report of Kummell's disease with delayed onset myelopathy and the literature review. ( 28913640 )
2017
3
Failed Percutaneous Vertebroplasty Due to Insufficient Correction of Intravertebral Instability in Kummell's Disease: A Case Report. ( 28160398 )
2017
4
Bone Cement-Augmented Percutaneous Short Segment Fixation: An Effective Treatment for Kummell's Disease? ( 26279814 )
2015
5
Spontaneous air reduction of vertebra plana with Kummell's disease during vertebroplasty: subsequent experience with an intentional trial. ( 24716992 )
2014
6
Cannula-induced Vertebral Reduction during Kyphoplasty in a Patient with Kummell's Disease. ( 22514785 )
2012
7
A case of posterior element fracture in Kummell's disease. ( 21811863 )
2012
8
Chronic Spinal Epidural Hematoma Related to Kummell's Disease. ( 21607183 )
2011
9
Cement augmented anterior reconstruction with short posterior instrumentation: a less invasive surgical option for Kummell's disease with cord compression. ( 21315603 )
2011
10
Spontaneous Vertebral Reduction during the Procedure of Kyphoplasty in a Patient with Kummell's Disease. ( 22220246 )
2011
11
Kummell's disease: delayed post-traumatic osteonecrosis of the vertebral body. ( 19949820 )
2010
12
Percutaneous vertebroplasty as treatment for Kummell's disease. ( 19534241 )
2009
13
Delayed post-traumatic osteonecrosis of a vertebral body (Kummell's disease). ( 11915453 )
2002
14
From surgical imaging...standard and fluoroscopic radiographs demonstrate the instability of thoracic compression fractures and the confluence of findings in fractures resulting from osteoporosis and those resulting from Kummell's disease. ( 14598806 )
2002
15
Delayed post-traumatic vertebral collapse (Kummell's disease): case report with serial radiographs, computed tomographic scans, and bone scans. ( 8362333 )
1993
16
KUMMELL'S DISEASE. ( 20775217 )
1930

Variations for Kummell's Disease

Expression for Kummell's Disease

Search GEO for disease gene expression data for Kummell's Disease.

Pathways for Kummell's Disease

GO Terms for Kummell's Disease

Cellular components related to Kummell's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 DKK1 EPHA3 SOST TNFRSF11B TNFSF11

Biological processes related to Kummell's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.54 DKK1 EPHA3 PLK2
2 multicellular organism development GO:0007275 9.46 DKK1 EPHA3 TNFRSF11B TNFSF11
3 regulation of signaling receptor activity GO:0010469 9.43 DKK1 TNFRSF11B TNFSF11
4 ossification GO:0001503 9.32 SOST TNFSF11
5 negative regulation of BMP signaling pathway GO:0030514 8.96 DKK1 SOST
6 negative regulation of ossification GO:0030279 8.62 DKK1 SOST

Sources for Kummell's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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