MCID: KMM001
MIFTS: 25

Kummell's Disease

Categories: Bone diseases

Aliases & Classifications for Kummell's Disease

MalaCards integrated aliases for Kummell's Disease:

Name: Kummell's Disease 12 15
Traumatic Spondylopathy 12 71 32
Kummell's Spondylitis 12
Kummell Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6603
ICD9CM 34 721.7
SNOMED-CT 67 65753008
ICD10 32 M48.3
UMLS 71 C0152088

Summaries for Kummell's Disease

MalaCards based summary : Kummell's Disease, also known as traumatic spondylopathy, is related to osteonecrosis and spondylitis. An important gene associated with Kummell's Disease is PPAN (Peter Pan Homolog), and among its related pathways/superpathways are Lissencephaly gene (LIS1) in neuronal migration and development and TNFs bind their physiological receptors. Affiliated tissues include bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Kummell's Disease

Diseases related to Kummell's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis 30.3 TNFSF11 TNFRSF11B DKK1
2 spondylitis 30.1 TNFSF11 SOST DKK1
3 back pain 10.3
4 avascular necrosis 10.3
5 spinal disease 10.3
6 inflammatory spondylopathy 10.2
7 sclerosteosis 1 10.2 SOST DKK1
8 craniodiaphyseal dysplasia 10.2 SOST DKK1
9 osteoporosis 10.1
10 bone mineral density quantitative trait locus 8 10.1
11 bone mineral density quantitative trait locus 15 10.1
12 polyarticular onset juvenile idiopathic arthritis 10.1 TNFSF11 TNFRSF11B
13 spinal stenosis 10.1
14 pulmonary embolism 10.1
15 paresthesia 10.1
16 hemophilic arthropathy 10.1 TNFSF11 TNFRSF11B
17 periodontitis, chronic 10.1 TNFSF11 TNFRSF11B
18 paget disease of bone 5, juvenile-onset 10.1 TNFSF11 TNFRSF11B
19 multicentric reticulohistiocytosis 10.1 TNFSF11 TNFRSF11B
20 familial expansile osteolysis 10.1 TNFSF11 TNFRSF11B
21 chronic apical periodontitis 10.0 TNFSF11 TNFRSF11B
22 osteoporosis-pseudoglioma syndrome 10.0 TNFRSF11B SOST DKK1
23 multicentric carpotarsal osteolysis syndrome 10.0 TNFSF11 TNFRSF11B
24 pycnodysostosis 10.0 TNFSF11 SOST
25 periapical periodontitis 10.0 TNFSF11 TNFRSF11B
26 tooth resorption 9.9 TNFSF11 TNFRSF11B
27 poems syndrome 9.9 TNFSF11 TNFRSF11B
28 bone giant cell tumor 9.9 TNFSF11 TNFRSF11B
29 renal osteodystrophy 9.9 TNFSF11 TNFRSF11B SOST
30 parathyroid gland disease 9.8 TNFSF11 TNFRSF11B SOST
31 endosteal hyperostosis, autosomal dominant 9.8 TNFSF11 TNFRSF11B SOST
32 pigmented villonodular synovitis 9.8 TNFSF11 TNFRSF11B
33 primary hyperparathyroidism 9.8 TNFSF11 TNFRSF11B SOST
34 hyperparathyroidism 9.8 TNFSF11 TNFRSF11B SOST
35 craniometaphyseal dysplasia, autosomal dominant 9.7 TNFSF11 TNFRSF11B
36 ischemic bone disease 9.6 TNFSF11 TNFRSF11B SOST DKK1
37 bone disease 9.6 TNFSF11 TNFRSF11B SOST DKK1
38 glucocorticoid-induced osteoporosis 9.6 TNFSF11 TNFRSF11B SOST DKK1
39 van buchem disease 9.6 TNFSF11 TNFRSF11B SOST DKK1
40 osteoporosis, juvenile 9.6 TNFSF11 TNFRSF11B SOST DKK1
41 sclerosteosis 9.6 TNFSF11 TNFRSF11B SOST DKK1
42 bone resorption disease 9.6 TNFSF11 TNFRSF11B SOST DKK1
43 bone remodeling disease 9.6 TNFSF11 TNFRSF11B SOST DKK1
44 brittle bone disorder 9.6 TNFSF11 TNFRSF11B SOST DKK1
45 paget's disease of bone 9.6 TNFSF11 TNFRSF11B SOST DKK1
46 gingival disease 9.6 TNFSF11 TNFRSF11B
47 myeloma, multiple 9.5 TNFSF11 TNFRSF11B SOST DKK1
48 connective tissue disease 9.1 TNFSF11 TNFRSF11B SOST CSNK2A1

Graphical network of the top 20 diseases related to Kummell's Disease:



Diseases related to Kummell's Disease

Symptoms & Phenotypes for Kummell's Disease

GenomeRNAi Phenotypes related to Kummell's Disease according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.83 EPHA3
2 Decreased viability GR00221-A-1 9.83 STK10
3 Decreased viability GR00221-A-2 9.83 STK10
4 Decreased viability GR00221-A-3 9.83 STK10
5 Decreased viability GR00221-A-4 9.83 EPHA3 PLK2
6 Decreased viability GR00301-A 9.83 EPHA3
7 Decreased viability GR00342-S-1 9.83 EPHA3 PLK2 STK10
8 Decreased viability GR00342-S-2 9.83 STK10
9 Decreased viability GR00342-S-3 9.83 STK10
10 Decreased viability GR00402-S-2 9.83 EPHA3 PLK2 STK10
11 Increased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 8.92 CSNK2A1 EPHA3 PLK2 STK10

Drugs & Therapeutics for Kummell's Disease

Search Clinical Trials , NIH Clinical Center for Kummell's Disease

Genetic Tests for Kummell's Disease

Anatomical Context for Kummell's Disease

MalaCards organs/tissues related to Kummell's Disease:

40
Bone

Publications for Kummell's Disease

Articles related to Kummell's Disease:

(show all 26)
# Title Authors PMID Year
1
Acute burst fracture in Kummell's disease with acute onset neurological deficit: a case report on role of spinal stability and technical notes on "pivot ligamentotaxis". 61
31088435 2019
2
Anterior reconstruction versus posterior osteotomy in treating Kümmell's disease with neurological deficits: A systematic review. 61
29803679 2018
3
Case report of Kummell's disease with delayed onset myelopathy and the literature review. 61
28913640 2018
4
Posttraumatic Delayed Vertebral Collapse : Kummell's Disease. 61
29354230 2018
5
Failed Percutaneous Vertebroplasty Due to Insufficient Correction of Intravertebral Instability in Kummell's Disease: A Case Report. 61
28160398 2017
6
Nomogram for Predicting Intradiscal Cement Leakage Following Percutaneous Vertebroplasty in Patients with Osteoporotic Related Vertebral Compression Fractures. 61
28535560 2017
7
[Diagnostic analysis of the radiologic characteristics in osteoporotic Kiinmmel's disease]. 61
27505965 2016
8
Percutaneous Kyphoplasty for Kummell Disease with Severe Spinal Canal Stenosis. 61
26606016 2015
9
[GRADED INFUSION OF BONE CEMENT IN PERCUTANEOUS VERTEBROPLASTY FOR Kummell's DISEASE]. 61
26749736 2015
10
Bone Cement-Augmented Percutaneous Short Segment Fixation: An Effective Treatment for Kummell's Disease? 61
26279814 2015
11
[Clinical efficacy of unipedicular versus bipedicular percutaneous vertebroplasty for Kummell's disease]. 61
25263378 2014
12
Spontaneous air reduction of vertebra plana with Kummell's disease during vertebroplasty: subsequent experience with an intentional trial. 61
24716992 2014
13
Pathomechanism of intravertebral clefts in osteoporotic compression fractures of the spine. 61
24055039 2014
14
[Balloon kyphoplasty for the treatment of osteoporotic Kummell's disease]. 61
23937040 2013
15
A case of posterior element fracture in Kummell's disease. 61
21811863 2012
16
Cannula-induced Vertebral Reduction during Kyphoplasty in a Patient with Kummell's Disease. 61
22514785 2012
17
Spontaneous Vertebral Reduction during the Procedure of Kyphoplasty in a Patient with Kummell's Disease. 61
22220246 2011
18
Chronic Spinal Epidural Hematoma Related to Kummell's Disease. 61
21607183 2011
19
Cement augmented anterior reconstruction with short posterior instrumentation: a less invasive surgical option for Kummell's disease with cord compression. 61
21315603 2011
20
Kummell's disease: delayed post-traumatic osteonecrosis of the vertebral body. 61
19949820 2010
21
Percutaneous vertebroplasty as treatment for Kummell's disease. 61
19534241 2009
22
Delayed posttraumatic vertebral collapse with intravertebral vacuum cleft. 61
12021746 2002
23
Delayed post-traumatic osteonecrosis of a vertebral body (Kummell's disease). 61
11915453 2002
24
From surgical imaging...standard and fluoroscopic radiographs demonstrate the instability of thoracic compression fractures and the confluence of findings in fractures resulting from osteoporosis and those resulting from Kummell's disease. 61
14598806 2002
25
Delayed post-traumatic vertebral collapse (Kummell's disease): case report with serial radiographs, computed tomographic scans, and bone scans. 61
8362333 1993
26
KUMMELL'S DISEASE. 61
20775217 1930

Variations for Kummell's Disease

Expression for Kummell's Disease

Search GEO for disease gene expression data for Kummell's Disease.

Pathways for Kummell's Disease

GO Terms for Kummell's Disease

Cellular components related to Kummell's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.28 VWA2 VWA1 TNFSF11 TNFRSF11B SOST LRPAP1

Biological processes related to Kummell's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of ossification GO:0030279 8.96 SOST DKK1
2 growth plate cartilage chondrocyte morphogenesis GO:0003429 8.62 VWA2 VWA1

Molecular functions related to Kummell's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor antagonist activity GO:0048019 8.96 LRPAP1 DKK1
2 low-density lipoprotein particle receptor binding GO:0050750 8.62 LRPAP1 DKK1

Sources for Kummell's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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