MCID: KYS001
MIFTS: 39

Kyasanur Forest Disease

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Kyasanur Forest Disease

MalaCards integrated aliases for Kyasanur Forest Disease:

Name: Kyasanur Forest Disease 12 76 53 59 3 44 15 73
Kfd 53 3
Kyasanur Hemorrhagic Fever 59
Monkey Diseases 73
Monkey Disease 59
Monkey Fever 59
Kfd Virus 53

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11320
ICD10 33 A98.2
ICD9CM 35 065.2
MeSH 44 D007733
SNOMED-CT 68 23097003
Orphanet 59 ORPHA319254
UMLS via Orphanet 74 C0022810
ICD10 via Orphanet 34 A98.2

Summaries for Kyasanur Forest Disease

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Kyasanur forest disease virus, which is transmitted by Haemaphysalis spinigera tick bite. The infection has symptom fever, has symptom headache, has symptom stiffness of the neck, has symptom severe muscle pain, has symptom cough, has symptom dehydration, and has symptom bleeding problems.

MalaCards based summary : Kyasanur Forest Disease, also known as kfd, is related to marburg hemorrhagic fever and zika fever, and has symptoms including fever, headache and stiffness of the neck. An important gene associated with Kyasanur Forest Disease is RAF1 (Raf-1 Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are PEDF Induced Signaling and 4-1BB Pathway. Affiliated tissues include testes and brain.

CDC : 3 Kyasanur Forest disease (KFD) is caused by Kyasanur Forest disease virus (KFDV), a member of the virus family Flaviviridae. KFDV was identified in 1957 when it was isolated from a sick monkey from the Kyasanur Forest in Karnataka (formerly Mysore) State, India. Since then, between 400-500 humans cases per year have been reported.

Wikipedia : 76 Kyasanur Forest disease (KFD) is a tick-borne viral hemorrhagic fever endemic to South Asia. The disease... more...

Related Diseases for Kyasanur Forest Disease

Diseases related to Kyasanur Forest Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 marburg hemorrhagic fever 11.0
2 zika fever 10.4 CD40LG RAF1
3 encephalitis 10.4
4 respiratory system benign neoplasm 10.3 KRAS RAF1
5 fasciolopsiasis 10.3 CD40LG IFNA1
6 tick-borne encephalitis 10.3
7 hemorrhagic fever 10.3
8 cryoglobulinemia, familial mixed 10.3 CD40LG IFNA1
9 dengue disease 10.2 CD40LG RAF1
10 pulmonic stenosis 10.2 KRAS RAF1
11 lung lymphoma 10.2 ALK CD40LG
12 lung adenoid cystic carcinoma 10.2 ALK KRAS
13 louping ill 10.2 CD40LG ERVW-1
14 rheumatoid lung disease 10.1 CD40LG ERVW-1
15 adenosquamous cell lung carcinoma 10.1 ALK KRAS
16 phlebotomus fever 10.1 CD40LG ERVW-1
17 exanthem 10.1 CD40LG KRAS
18 transient arthritis 10.1 CD40LG ERVW-1
19 lung benign neoplasm 10.1 KRAS RAF1
20 mucinous adenocarcinoma 10.1 ALK KRAS
21 spinal cord disease 10.1 CD40LG ERVW-1
22 chikungunya 10.0
23 alkhurma hemorrhagic fever 10.0
24 type i 10.0
25 leukocyte disease 10.0 CD40LG IFNA1
26 severe acute respiratory syndrome 9.9 CD40LG IFNA1
27 chlamydia 9.9 CD40LG RAF1
28 coccidiosis 9.8 CD40LG NPCDR1
29 lung cancer susceptibility 3 9.7 ALK KRAS RAF1
30 myeloma, multiple 9.6 CD40LG IFNA1 KRAS
31 st. louis encephalitis 9.6 ERVW-1 KRAS RAF1
32 human immunodeficiency virus infectious disease 9.6 CD40LG ERVW-1 IFNA1
33 viral infectious disease 9.5 CD40LG ERVW-1 IFNA1
34 parasitic protozoa infectious disease 9.5 CD40LG NPCDR1
35 respiratory system cancer 9.4 ALK KRAS
36 human immunodeficiency virus type 1 9.3 ERVW-1 IFNA1 RAF1
37 murray valley encephalitis 9.1 CD40LG ERVW-1 KRAS RAF1

Graphical network of the top 20 diseases related to Kyasanur Forest Disease:



Diseases related to Kyasanur Forest Disease

Symptoms & Phenotypes for Kyasanur Forest Disease

Symptoms:

12
  • fever
  • headache
  • stiffness of the neck
  • severe muscle pain
  • cough
  • dehydration
  • bleeding problems

Drugs & Therapeutics for Kyasanur Forest Disease

Search Clinical Trials , NIH Clinical Center for Kyasanur Forest Disease

Cochrane evidence based reviews: kyasanur forest disease

Genetic Tests for Kyasanur Forest Disease

Anatomical Context for Kyasanur Forest Disease

MalaCards organs/tissues related to Kyasanur Forest Disease:

41
Testes, Brain

Publications for Kyasanur Forest Disease

Articles related to Kyasanur Forest Disease:

(show top 50) (show all 130)
# Title Authors Year
1
Prevalence and spatial distribution of Ixodid tick populations in the forest fringes of Western Ghats reported with human cases of Kyasanur forest disease and monkey deaths in South India. ( 29594846 )
2018
2
Development of single step RT-PCR for detection of Kyasanur forest disease virus from clinical samples. ( 29560461 )
2018
3
Bioinformatics characterization of envelope glycoprotein from Kyasanur Forest disease virus. ( 29806609 )
2018
4
Comparative genome analysis of Alkhumra hemorrhagic fever virus with Kyasanur forest disease and tick-borne encephalitis viruses by the in silico approach. ( 29745301 )
2018
5
Epidemiology, Pathogenesis, and Control of a Tick-Borne Disease- Kyasanur Forest Disease: Current Status and Future Directions. ( 29868505 )
2018
6
Kyasanur Forest Disease Prevalence in Western Ghats Proven and Confirmed by Recent Outbreak in Maharashtra, India, 2016. ( 29336707 )
2018
7
Preliminary risk maps for transmission of kyasanur forest disease in Southern India. ( 28218163 )
2017
8
Occupational exposure of cashew nut workers to Kyasanur Forest disease in Goa, India. ( 28627428 )
2017
9
An outbreak of Kyasanur forest disease in the Wayanad and Malappuram districts of Kerala, India. ( 27692988 )
2017
10
Kyasanur forest disease: Another flavivirus requiring more research? Results of a bibliometric assessment. ( 28843350 )
2017
11
Kyasanur forest disease virus breaking the endemic barrier: AnA investigation into ecological effects on disease emergence and future outlook. ( 28220635 )
2017
12
Development of a subgenomic clone system for Kyasanur Forest disease virus. ( 27357207 )
2016
13
Kyasanur Forest Disease - First Reported Case in Kerala. ( 27731570 )
2016
14
Kyasanur Forest Disease (KFD): Rare Disease of Zoonotic Origin. ( 28327690 )
2016
15
Outbreak of Kyasanur Forest disease (monkey fever) in Sindhudurg, Maharashtra State, India, 2016. ( 26997635 )
2016
16
An Early Passage Human Isolate of Kyasanur Forest Disease Virus Shows Acute Neuropathology in Experimentally Infected CD-1 Mice. ( 27171207 )
2016
17
Difference in vector ticks dropping rhythm governs the epidemiology of Crimean-Congo haemorrhagic fever & Kyasanur forest disease in India. ( 28256476 )
2016
18
Limited Effects of Type I Interferons on Kyasanur Forest Disease Virus in Cell Culture. ( 27479197 )
2016
19
Kyasanur Forest disease outbreak and vaccination strategy,Shimoga District, India, 2013-2014. ( 25531141 )
2015
20
On the transmission pattern of Kyasanur Forest disease (KFD) in India. ( 26286631 )
2015
21
New focus of Kyasanur Forest disease virus activity in a tribal area in Kerala, India, 2014. ( 25750730 )
2015
22
Comparative pathogenesis of Alkhumra hemorrhagic fever and Kyasanur forest disease viruses in a mouse model. ( 24922308 )
2014
23
Outbreak of Kyasanur Forest disease in Thirthahalli, Karnataka, India, 2014. ( 25063021 )
2014
24
Kyasanur Forest disease virus infection in mice is associated with higher morbidity and mortality than infection with the closely related Alkhurma hemorrhagic fever virus. ( 24950196 )
2014
25
Expediency of dengue illness classification: the Sri Lankan perspective Highly infectious tick-borne viral diseases: Kyasanur forest disease and Crimean-Congo haemorrhagic fever in India. ( 28607249 )
2014
26
Coverage and effectiveness of Kyasanur forest disease (KFD) vaccine in Karnataka, South India, 2005-10. ( 23359421 )
2013
27
Spread of Kyasanur Forest disease, Bandipur Tiger Reserve, India, 2012-2013. ( 23977946 )
2013
28
Kyasanur Forest disease, India, 2011-2012. ( 23343570 )
2013
29
The generation of a reverse genetics system for Kyasanur Forest Disease Virus and the ability to antagonize the induction of the antiviral state in vitro. ( 22100401 )
2012
30
Kyasanur forest disease virus: viremia and challenge studies in monkeys with evidence of cross-protection by Langat virus infection. ( 24627765 )
2012
31
Diagnosis of Kyasanur forest disease by nested RT-PCR, real-time RT-PCR and IgM capture ELISA. ( 22874757 )
2012
32
Kyasanur forest disease. ( 23110991 )
2012
33
Kyasanur Forest Disease virus Alkhurma subtype in ticks, Najran Province, Saudi Arabia. ( 21529425 )
2011
34
Recent ancestry of Kyasanur Forest disease virus. ( 19788811 )
2009
35
Isolation of kyasanur forest disease virus from febrile patient, yunnan, china. ( 19193286 )
2009
36
Kyasanur forest disease: an epidemiological view in India. ( 16710839 )
2006
37
Field evaluation of formalin inactivated Kyasanur forest disease virus tissue culture vaccine in three districts of Karnataka state. ( 7927566 )
1994
38
Analysis of the structural protein gene sequence shows Kyasanur Forest disease virus as a distinct member in the tick-borne encephalitis virus serocomplex. ( 8113732 )
1994
39
Clinical study of 100 cases of Kyasanur Forest disease with clinicopathological correlation. ( 8225455 )
1993
40
Circulating interferon-alpha in patients with Kyasanur forest disease. ( 1959947 )
1991
41
Clinical, clinicopathologic, and hematologic features of Kyasanur Forest disease. ( 2665018 )
1989
42
The epizootics of Kyasanur Forest disease in wild monkeys during 1964 to 1973. ( 3603621 )
1986
43
Spatial distribution of infected Haemaphysalis nymphs in the epizootic localities of Kyasanur forest disease. ( 6668008 )
1983
44
Ocular manifestations of Kyasanur forest disease (a clinical study). ( 6671795 )
1983
45
Ocular changes in Kyasanur forest disease. ( 6674351 )
1983
46
Persistence of humoral immunity in Kyasanur forest disease. ( 6263796 )
1981
47
The reaction of Funambulus tristriatus tristriatus Rattus blanfordi and Suncus murinus to Kyasanur forest disease virus. ( 6273309 )
1981
48
Attenuated Langat E5 virus as a live virus vaccine against Kyasanur Forest disease virus. ( 6263797 )
1981
49
Serological response to formolized Kyasanur forest disease virus vaccine in humans at Sagar and Sorab Talukas of Shimoga district. ( 6249824 )
1980
50
Studies on the transmission of Kyasanur forest disease virus by partly fed ixodid ticks. ( 229077 )
1979

Variations for Kyasanur Forest Disease

Expression for Kyasanur Forest Disease

Search GEO for disease gene expression data for Kyasanur Forest Disease.

Pathways for Kyasanur Forest Disease

Pathways related to Kyasanur Forest Disease according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.26 ALK CD40LG IFNA1 KRAS RAF1
2
Show member pathways
12.31 CD40LG KRAS RAF1
3
Show member pathways
12.2 IFNA1 KRAS RAF1
4
Show member pathways
12.11 IFNA1 KRAS RAF1
5
Show member pathways
12.02 CD40LG KRAS RAF1
6 11.98 ALK IFNA1 KRAS RAF1
7 11.44 KRAS RAF1
8 11.38 KRAS RAF1
9
Show member pathways
11.37 KRAS RAF1
10 11.33 KRAS RAF1
11 11.28 IFNA1 KRAS RAF1
12 11.18 KRAS RAF1
13 11.1 KRAS RAF1
14 10.92 IFNA1 KRAS RAF1
15 10.88 KRAS RAF1
16 10.8 KRAS RAF1
17 10.66 KRAS RAF1
18 10.56 KRAS RAF1

GO Terms for Kyasanur Forest Disease

Biological processes related to Kyasanur Forest Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 9.16 CD40LG IFNA1
2 B cell proliferation GO:0042100 8.96 CD40LG IFNA1
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 8.8 ALK CD40LG KRAS

Molecular functions related to Kyasanur Forest Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitogen-activated protein kinase kinase binding GO:0031434 8.62 ALK RAF1

Sources for Kyasanur Forest Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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