MCID: LCR004
MIFTS: 42

La Crosse Encephalitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for La Crosse Encephalitis

MalaCards integrated aliases for La Crosse Encephalitis:

Name: La Crosse Encephalitis 11 19 58 2 14 71 75 33
California Encephalitis 11 19 31 33
Neuroinvasive California Encephalitis Virus Infection 11 33
California Virus Encephalitis 11 33
Californian Encephalitis 19 58
Encephalitis, California 43 71
California Encephalitis Virus Infection Neuroinvasive Disease 33
California Serogroup Virus Neuroinvasive Disease 33
California Meningoencephalitis Virus Disease 33
California Encephalitis Virus Infection 33
California Meningoencephalitis 33
Ce - [california Encephalitis] 33
Lac - [la Crosse Encephalitis] 33
California Viral Encephalitis 33

Characteristics:


Prevelance:

1-9/100000 (Canada) 58

Age Of Onset:

All ages 58

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare infectious diseases


External Ids:

Disease Ontology 11 DOID:0050118
ICD9CM 34 062.5
MeSH 43 D004670
SNOMED-CT 68 69627004
ICD10 31 A83.5
MESH via Orphanet 44 D004670
ICD10 via Orphanet 32 A83.5
UMLS via Orphanet 72 C0014053
Orphanet 58 ORPHA83483
UMLS 71 C0014053 C0276379

Summaries for La Crosse Encephalitis

GARD: 19 La Crosse (LAC) encephalitis is a mosquito-borne virus that was first described in La Crosse, Wisconsin in 1963. Since then, it has been reported in several Midwestern and Mid-Atlantic states. The LAC virus is one of many mosquito-transmitted viruses that can cause an inflammation of the brain (encephalitis). About 80-100 cases of this condition are reported each year in the United States. Most cases occur in children younger than age 16. While most people who become infected have no symptoms, those who do become ill may have fever, headache, vomiting and lethargy (tiredness). Severe cases develop encephalitis accompanied by seizures. Coma and paralysis occur in some cases.

MalaCards based summary: La Crosse Encephalitis, also known as california encephalitis, is related to encephalitis and viral encephalitis, and has symptoms including fever, headache and coma. An important gene associated with La Crosse Encephalitis is LGI1 (Leucine Rich Glioma Inactivated 1), and among its related pathways/superpathways are CREB Pathway and Complement cascade. Affiliated tissues include brain, temporal lobe and skin, and related phenotypes are nervous system and vision/eye

Orphanet: 58 An acute arboviral infection caused by the La Crosse bunyavirus transmitted by an infected mosquito, usually observed in infants, children or adolescents (6 months to 16 years), and characterized by the onset of flulike symptoms such as fever, chills, nausea, vomiting, headache, and abdominal pain, followed by the onset of encephalitis characterized by somnolence, obtundation, and even seizures, focal neurologic signs (asymmetrical reflexes or Babinski signs), paralysis or even coma. CE can leave sequelae such as residual epilepsy and neurocognitive deficits.

CDC: 2 La Crosse encephalitis is a viral disease spread to people by the bite of an infected mosquito. Most cases occur in the upper Midwestern, mid-Atlantic, and southeastern states. Many people infected have no apparent symptoms. Some of those who become ill develop severe neuroinvasive disease (disease that affects the nervous system). Severe disease often involves encephalitis (an inflammation of the brain) and can include seizures, coma, and paralysis. Severe disease occurs most often in children under the age of 16.

Disease Ontology: 11 A viral infectious disease that results in inflammation located in brain, has material basis in La Crosse virus, which is transmitted by treehole mosquito, Ochlerotatus triseriatus. The infection has symptom seizures, has symptom headache, has symptom fever, has symptom coma, and has symptom paralysis.

Wikipedia: 75 La Crosse encephalitis is an encephalitis caused by an arbovirus (the La Crosse virus) which has a... more...

Related Diseases for La Crosse Encephalitis

Diseases related to La Crosse Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 encephalitis 31.2 PNMA2 LGI1 CNTNAP2 AMPH
2 viral encephalitis 30.5 PNMA2 LGI1 CNTNAP2 AMPH
3 zika fever 30.2 TYRO3 AXL
4 acute disseminated encephalomyelitis 28.7 PNMA2 LGI1 IGLON5 DPYSL5 DPP6 CNTNAP2
5 meningoencephalitis 10.4
6 viral infectious disease 10.4
7 herpes simplex encephalitis 10.4
8 herpes simplex 10.3
9 auditory agnosia 10.2 LGI1 CNTNAP2
10 transient global amnesia 10.2 LGI1 CNTNAP2
11 dissociative amnesia 10.2 LGI1 CNTNAP2
12 gallbladder small cell carcinoma 10.2 LGI1 CNTNAP2
13 drug psychosis 10.2 LGI1 CNTNAP2
14 partial motor epilepsy 10.2 LGI1 CNTNAP2
15 akinetic mutism 10.2 PNMA2 LGI1
16 ocular motor apraxia 10.1
17 west nile virus 10.1
18 chikungunya 10.1
19 aphasia 10.1
20 eastern equine encephalitis 10.1
21 aseptic meningitis 10.1
22 dengue disease 10.1
23 gastroenteritis 10.1
24 bacterial meningitis 10.1
25 autoimmune encephalitis 10.1
26 echolalia 10.1 LGI1 CNTNAP2
27 vascular myelopathy 10.1 DPYSL5 AMPH
28 cerebellopontine angle meningioma 10.1 DPYSL5 AMPH
29 drug-induced mental disorder 10.1 LGI1 GRIN1 CNTNAP2
30 speech disorder 10.1 LGI1 GRIN1 CNTNAP2
31 st. louis encephalitis 10.1
32 fallopian tube serous adenocarcinoma 10.0 PNMA2 AMPH
33 epilepsy, familial temporal lobe, 1 10.0 LGI1 CNTNAP2
34 western equine encephalitis 10.0
35 bronchitis 10.0
36 nmda receptor encephalitis 10.0
37 benign epilepsy with centrotemporal spikes 10.0 LGI1 GRIN1 CNTNAP2
38 demyelinating polyneuropathy 10.0 LGI1 IGLON5 CNTNAP2
39 recurrent hypersomnia 9.9 PNMA2 LGI1 IGLON5
40 kleine-levin hibernation syndrome 9.9 PNMA2 LGI1 IGLON5
41 cerebellar disease 9.9 DPYSL5 CNTNAP2 AMPH
42 amnestic disorder 9.9 LGI1 CNTNAP2
43 polyradiculopathy 9.9 LGI1 DPYSL5 CNTNAP2 AMPH
44 transverse myelitis 9.9 LGI1 DPYSL5 CNTNAP2 AMPH
45 gummatous syphilis 9.9 PNMA2 LGI1 CNTNAP2 AMPH
46 meningovascular neurosyphilis 9.9 PNMA2 LGI1 CNTNAP2 AMPH
47 miller fisher syndrome 9.9 PNMA2 LGI1 CNTNAP2 AMPH
48 von economo's disease 9.9 LGI1 IGLON5 DPP6 CNTNAP2
49 autoimmune neuropathy 9.8 LGI1 IGLON5 DPYSL5 CNTNAP2
50 neurosarcoidosis 9.8 PNMA2 LGI1 DPYSL5 AMPH

Graphical network of the top 20 diseases related to La Crosse Encephalitis:



Diseases related to La Crosse Encephalitis

Symptoms & Phenotypes for La Crosse Encephalitis

Symptoms:

11
  • fever
  • headache
  • coma
  • paralysis
  • seizures

MGI Mouse Phenotypes related to La Crosse Encephalitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.61 AMPH AXL CNTNAP2 DPP6 DPYSL5 GRIN1
2 vision/eye MP:0005391 9.17 AXL GAS6 GRIN1 IGLON5 LGI1 MERTK

Drugs & Therapeutics for La Crosse Encephalitis

Search Clinical Trials, NIH Clinical Center for La Crosse Encephalitis

Cochrane evidence based reviews: encephalitis, california

Genetic Tests for La Crosse Encephalitis

Anatomical Context for La Crosse Encephalitis

Organs/tissues related to La Crosse Encephalitis:

FMA: Brain
MalaCards : Brain, Temporal Lobe, Skin

Publications for La Crosse Encephalitis

Articles related to La Crosse Encephalitis:

(show top 50) (show all 299)
# Title Authors PMID Year
1
Laboratory Validation of a Real-Time RT-PCR Assay for the Detection of Jamestown Canyon Virus. 62
35631056 2022
2
Development of a Community-Driven Mosquito Surveillance Program for Vectors of La Crosse Virus to Educate, Inform, and Empower a Community. 62
35206737 2022
3
Peridomestic conditions affect La Crosse virus entomological risk by modifying the habitat use patterns of its mosquito vectors. 62
35229580 2021
4
Acute Fulminant Cerebral Edema: A Newly Recognized Phenotype in Children With Suspected Encephalitis. 62
32667036 2021
5
Prospective Cohort Study of Next-Generation Sequencing as a Diagnostic Modality for Unexplained Encephalitis in Children. 62
31107955 2020
6
Double Crossed: A Case of La Crosse Encephalitis. 62
32236166 2020
7
Spatial-temporal clusters of host-seeking Aedes albopictus, Aedes japonicus, and Aedes triseriatus collections in a La Crosse virus endemic county (Knox County, Tennessee, USA). 62
32881929 2020
8
Ongoing and emerging arbovirus threats in Europe. 62
30176404 2018
9
Notes from the Field: Spatially Associated Coincident and Noncoincident Cases of La Crosse Encephalitis - North Carolina, 2002-2017. 62
30286057 2018
10
Modeling a single season of Aedes albopictus populations based on host-seeking data in response to temperature and precipitation in eastern Tennessee. 62
29757517 2018
11
Serological surveillance for Tahyna virus (California encephalitis orthobunyavirus, Peribunyaviridae) neutralizing antibodies in wild ungulates in Austria, Hungary and Romania. 62
29516663 2018
12
La Crosse Virus Vectors Are Host-Seeking and Ovipositing After 1700 H in Eastern Tennessee. 62
28854104 2017
13
Characterization of five unclassified orthobunyaviruses (Bunyaviridae) from Africa and the Americas. 62
28885138 2017
14
Anti-N-Methyl-d-Aspartate Receptor Encephalitis Appearing as a New-Onset Psychosis: Disease Course in Children and Adolescents Within the California Encephalitis Project. 62
28506504 2017
15
Epidemiology of La Crosse Virus Emergence, Appalachia Region, United States. 62
27767009 2016
16
Rapid detection of European orthobunyaviruses by reverse transcription loop-mediated isothermal amplification assays. 62
27491341 2016
17
La Crosse Encephalitis: A Persistent Arboviral Threat in North Carolina. 62
27621342 2016
18
La Crosse Encephalitis: An Adult Case Series. 62
27086496 2016
19
A Genome-Wide RNA Interference Screen Identifies a Role for Wnt/β-Catenin Signaling during Rift Valley Fever Virus Infection. 62
27226375 2016
20
Serological Survey for Antibodies to Mosquito-Borne Bunyaviruses Among US National Park Service and US Forest Service Employees. 62
26855300 2016
21
The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. 62
26523970 2015
22
Genetic and Phylogenetic Characterization of Tataguine and Witwatersrand Viruses and Other Orthobunyaviruses of the Anopheles A, Capim, Guamá, Koongol, Mapputta, Tete, and Turlock Serogroups. 62
26610546 2015
23
Complete genome sequence of trivittatus virus. 62
26212363 2015
24
Neurological Outcomes After Presumed Childhood Encephalitis. 62
26220354 2015
25
La Crosse Encephalitis Virus Infection in Field-Collected Aedes albopictus, Aedes japonicus, and Aedes triseriatus in Tennessee. 62
26375904 2015
26
Epilepsy After Resolution of Presumed Childhood Encephalitis. 62
26092415 2015
27
Acute pediatric encephalitis neuroimaging: single-institution series as part of the California encephalitis project. 62
25846458 2015
28
Use of clinical and neuroimaging characteristics to distinguish temporal lobe herpes simplex encephalitis from its mimics. 62
25637586 2015
29
Cemeteries are effective sites for monitoring la crosse virus (LACv) and these environments may play a role in LACv infection. 62
25860584 2015
30
Insights into pediatric herpes simplex encephalitis from a cohort of 21 children from the California Encephalitis Project, 1998-2011. 62
24911898 2014
31
Isolation of Tahyna Virus (California Encephalitis Group) From Anopheles hyrcanus (Diptera, Culicidae), a Mosquito Species New to, and Expanding in, Central Europe. 62
26309316 2014
32
The role of continuous electroencephalography in childhood encephalitis. 62
24507696 2014
33
Isolation and characterization of a California encephalitis serogroup orthobunyavirus from Finnish mosquitoes. 62
24480054 2014
34
Arboviruses pathogenic for domestic and wild animals. 62
24751197 2014
35
Emerging trends in free-living amebic infections of the brain: implications for organ transplantation. 62
25073256 2013
36
Epidemiology, outcomes and predictors of recovery in childhood encephalitis: a hospital-based study. 62
23518823 2013
37
Encephalitis with thalamic and basal ganglia abnormalities: etiologies, neuroimaging, and potential role of respiratory viruses. 62
23196954 2013
38
Impacts of climate, land use, and biological invasion on the ecology of immature Aedes mosquitoes: implications for La Crosse emergence. 62
22692799 2012
39
[Molecular genetic analysis of Tahyna virus strains]. 62
22905424 2012
40
La Crosse encephalitis surveillance using single versus paired serologic testing. 62
21848528 2012
41
The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. 62
22281844 2012
42
Lack of association between childhood immunizations and encephalitis in California, 1998-2008. 62
22080172 2012
43
A recombinant chimeric La Crosse virus expressing the surface glycoproteins of Jamestown Canyon virus is immunogenic and protective against challenge with either parental virus in mice or monkeys. 62
22013033 2012
44
Safety and pharmacokinetics of ribavirin for the treatment of la crosse encephalitis. 62
21544005 2011
45
Tahyna virus genetics, infectivity, and immunogenicity in mice and monkeys. 62
21435229 2011
46
Varicella zoster disease of the central nervous system: epidemiological, clinical, and laboratory features 10 years after the introduction of the varicella vaccine. 62
21177308 2011
47
Interferon antagonist NSs of La Crosse virus triggers a DNA damage response-like degradation of transcribing RNA polymerase II. 62
21118815 2011
48
[Characteristic of the new Khatanga virus genotype]. 62
21786597 2011
49
[Arborviruses of the California encephalitis serogroup 1N Russia and their contribution to infectious pathology]. 62
21786596 2011
50
La Crosse virus neuroinvasive disease - Missouri, 2009. 62
20651642 2010

Variations for La Crosse Encephalitis

Expression for La Crosse Encephalitis

Search GEO for disease gene expression data for La Crosse Encephalitis.

Pathways for La Crosse Encephalitis

Pathways related to La Crosse Encephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 TYRO3 MERTK GRIN1 GAS6 AXL
2
Show member pathways
12.01 TYRO3 MERTK GAS6 AXL
3
Show member pathways
11.84 TYRO3 MERTK GAS6 AXL
4 11.43 TYRO3 MERTK GAS6 AXL
5 11.03 TYRO3 MERTK GAS6 AXL
6 10.53 TYRO3 MERTK GAS6 AXL

GO Terms for La Crosse Encephalitis

Cellular components related to La Crosse Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synaptic cleft GO:0043083 8.92 LGI1 GRIN1

Biological processes related to La Crosse Encephalitis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 10.3 TYRO3 MERTK LGI1 DPYSL5 AXL
2 establishment of localization in cell GO:0051649 10.1 TYRO3 MERTK AXL
3 neuron migration GO:0001764 10.1 TYRO3 GAS6 AXL
4 viral entry into host cell GO:0046718 10.09 TYRO3 GAS6 AXL
5 positive regulation of kinase activity GO:0033674 10.07 TYRO3 MERTK AXL
6 platelet activation GO:0030168 10.03 TYRO3 MERTK AXL
7 phagocytosis GO:0006909 10.03 TYRO3 MERTK GAS6 AXL
8 substrate adhesion-dependent cell spreading GO:0034446 9.99 TYRO3 MERTK AXL
9 protein kinase B signaling GO:0043491 9.97 TYRO3 MERTK GAS6 AXL
10 dendritic cell differentiation GO:0097028 9.91 GAS6 AXL
11 cellular response to interferon-alpha GO:0035457 9.9 AXL GAS6
12 positive regulation of cytokine-mediated signaling pathway GO:0001961 9.88 GAS6 AXL
13 natural killer cell differentiation GO:0001779 9.88 AXL MERTK TYRO3
14 negative regulation of dendritic cell apoptotic process GO:2000669 9.87 GAS6 AXL
15 positive regulation of natural killer cell differentiation GO:0032825 9.84 AXL GAS6
16 ovulation cycle GO:0042698 9.83 AXL TYRO3
17 positive regulation of viral life cycle GO:1903902 9.8 TYRO3 AXL
18 secretion by cell GO:0032940 9.8 TYRO3 MERTK AXL
19 neutrophil clearance GO:0097350 9.78 MERTK AXL
20 forebrain cell migration GO:0021885 9.76 TYRO3 AXL
21 multicellular organism development GO:0007275 9.75 TYRO3 MERTK AXL
22 vagina development GO:0060068 9.73 TYRO3 MERTK AXL
23 enzyme-linked receptor protein signaling pathway GO:0007167 9.72 AXL GAS6
24 apoptotic cell clearance GO:0043277 9.43 TYRO3 MERTK GAS6 AXL
25 lymphocyte activation GO:0046649 9.33 TYRO3 MERTK AXL
26 negative regulation of lymphocyte activation GO:0051250 9.1 TYRO3 MERTK AXL

Molecular functions related to La Crosse Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.55 TYRO3 MERTK AXL
2 phosphatidylinositol 3-kinase binding GO:0043548 9.26 TYRO3 AXL
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.1 TYRO3 MERTK AXL

Sources for La Crosse Encephalitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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