MCID: LCR004
MIFTS: 45

La Crosse Encephalitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for La Crosse Encephalitis

MalaCards integrated aliases for La Crosse Encephalitis:

Name: La Crosse Encephalitis 12 53 59 3 15 73
Californian Encephalitis 53 59
Encephalitis, California 44 73
California Encephalitis 12 53
Neuroinvasive California Encephalitis Virus Infection 12
California Virus Encephalitis 12

Characteristics:

Orphanet epidemiological data:

59
la crosse encephalitis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Canada); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:0050118
ICD10 33 A83.5
ICD9CM 35 062.5
MeSH 44 D004670
SNOMED-CT 68 69627004
Orphanet 59 ORPHA83483
MESH via Orphanet 45 D004670
UMLS via Orphanet 74 C0014053
ICD10 via Orphanet 34 A83.5

Summaries for La Crosse Encephalitis

NIH Rare Diseases : 53 La Crosse (LAC) encephalitis is a mosquito-borne virus that was first described in La Crosse, Wisconsin in 1963. Since then, it has been reported in several Midwestern and Mid-Atlantic states. The LAC virus is one of many mosquito-transmitted viruses that can cause an inflammation of the brain (encephalitis). About 80-100 cases of this condition are reported each year in the United States. Most cases occur in children younger than age 16. While most people who become infected have no symptoms, those who do become ill may have fever, headache, vomiting and lethargy (tiredness). Severe cases develop encephalitis accompanied by seizures. Coma and paralysis occur in some cases. There is no specific treatment for LAC encephalitis. Supportive therapy is provided to those who develop severe cases of the disease.

MalaCards based summary : La Crosse Encephalitis, also known as californian encephalitis, is related to viral infectious disease and herpes simplex, and has symptoms including seizures, fever and paralysis. An important gene associated with La Crosse Encephalitis is STAB2 (Stabilin 2), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. Affiliated tissues include brain, brain and testes, and related phenotypes are Decreased ionizing radiation sensitivity and cellular

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain, has material basis in La Crosse virus, which is transmitted by treehole mosquito, Ochlerotatus triseriatus. The infection has symptom seizures, has symptom headache, has symptom fever, has symptom coma, and has symptom paralysis.

CDC : 3 Ae. triseriatus is an aggressive daytime-biting mosquito, especially in or near infested woods.

Wikipedia : 76 La Crosse encephalitis is an encephalitis caused by an arbovirus (the La Crosse virus) which has a... more...

Related Diseases for La Crosse Encephalitis

Graphical network of the top 20 diseases related to La Crosse Encephalitis:



Diseases related to La Crosse Encephalitis

Symptoms & Phenotypes for La Crosse Encephalitis

Symptoms:

12
  • seizures
  • fever
  • paralysis
  • coma
  • headache

GenomeRNAi Phenotypes related to La Crosse Encephalitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased ionizing radiation sensitivity GR00232-A-1 9.17 AXL CXCL1 GALC GAS6 LUM MERTK

MGI Mouse Phenotypes related to La Crosse Encephalitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.07 AXL DDX58 GALC GAS6 H2AFX IRF3
2 homeostasis/metabolism MP:0005376 10.07 AXL DDX58 GALC GAS6 GPR180 H2AFX
3 cardiovascular system MP:0005385 10.06 AXL GALC GAS6 GPR180 H2AFX LUM
4 hematopoietic system MP:0005397 10.02 AXL DDX58 GALC GAS6 H2AFX IFNB1
5 immune system MP:0005387 9.9 AXL DDX58 GALC GAS6 H2AFX IFNB1
6 liver/biliary system MP:0005370 9.5 AXL DDX58 GALC MERTK POLR2A STAB2
7 vision/eye MP:0005391 9.17 AXL GALC GAS6 H2AFX LUM MERTK

Drugs & Therapeutics for La Crosse Encephalitis

Search Clinical Trials , NIH Clinical Center for La Crosse Encephalitis

Cochrane evidence based reviews: encephalitis, california

Genetic Tests for La Crosse Encephalitis

Anatomical Context for La Crosse Encephalitis

The Foundational Model of Anatomy Ontology organs/tissues related to La Crosse Encephalitis:

19
Brain

MalaCards organs/tissues related to La Crosse Encephalitis:

41
Brain, Testes

Publications for La Crosse Encephalitis

Articles related to La Crosse Encephalitis:

(show all 33)
# Title Authors Year
1
Notes from the Field: Spatially Associated Coincident and Noncoincident Cases of La Crosse Encephalitis - North Carolina, 2002-2017. ( 30286057 )
2018
2
La Crosse Encephalitis: A Persistent Arboviral Threat in North Carolina. ( 27621342 )
2016
3
La Crosse Encephalitis: An Adult Case Series. ( 27086496 )
2016
4
La Crosse Encephalitis Virus Infection in Field-Collected Aedes albopictus, Aedes japonicus, and Aedes triseriatus in Tennessee. ( 26375904 )
2015
5
La Crosse encephalitis surveillance using single versus paired serologic testing. ( 21848528 )
2012
6
Safety and pharmacokinetics of ribavirin for the treatment of la crosse encephalitis. ( 21544005 )
2011
7
Possible congenital infection with La Crosse encephalitis virus--West Virginia, 2006-2007. ( 19145220 )
2009
8
Periodic lateralized epileptiform discharges in La Crosse encephalitis, a worrisome subgroup: clinical presentation, electroencephalogram (EEG) patterns, and long-term neurologic outcome. ( 18160548 )
2008
9
Economic and social impacts of La Crosse encephalitis in western North Carolina. ( 14695088 )
2003
10
Clinical comparisons of La Crosse encephalitis and enteroviral central nervous system infections in a pediatric population: 2001 surveillance in East Tennessee. ( 14647115 )
2003
11
La Crosse encephalitis in Eastern Tennessee: clinical, environmental, and entomological characteristics from a blinded cohort study. ( 12034585 )
2002
12
Mobility of the piggyBac transposon in embryos of the vectors of Dengue fever (Aedes albopictus) and La Crosse encephalitis (Ae. triseriatus). ( 11370874 )
2001
13
La Crosse encephalitis in children. ( 11248155 )
2001
14
La Crosse encephalitis in children. ( 11450671 )
2001
15
Severe La Crosse encephalitis with significant neurologic sequelae. ( 10643856 )
2000
16
La Crosse encephalitis virus habitat associations in Nicholas County, West Virginia. ( 10916297 )
2000
17
La Crosse encephalitis presenting like herpes simplex encephalitis in an immunocompromised adult. ( 11049801 )
2000
18
Newly recognized focus of La Crosse encephalitis in Tennessee. ( 10028077 )
1999
19
California-La Crosse encephalitis. ( 9494831 )
1998
20
Treatment of severe La Crosse encephalitis with intravenous ribavirin following diagnosis by brain biopsy. ( 9024460 )
1997
21
Histocompatibility antigens and La Crosse encephalitis. ( 8335971 )
1993
22
Spatial distribution of Aedes triseriatus eggs in a site endemic for La Crosse encephalitis virus. ( 2370533 )
1990
23
La Crosse encephalitis in West Virginia. ( 3123907 )
1988
24
Leads from the MMWR. La Crosse encephalitis in West Virginia. ( 3339779 )
1988
25
La Crosse encephalitis: occurrence of disease and control in a suburban area. ( 6867036 )
1983
26
Mosquito control for prevention of California (La Crosse) encephalitis. ( 6688132 )
1983
27
Clinical aspects of La Crosse encephalitis: neurological and psychological sequelae. ( 6867035 )
1983
28
Clinical aspects of La Crosse encephalitis: preliminary report. ( 6867032 )
1983
29
Rapid diagnosis of La Crosse virus infections: evaluation of serologic and antigen detection techniques for the clinically relevant diagnosis of La Crosse encephalitis. ( 6346337 )
1983
30
Neurologic aspects and treatment of La Crosse encephalitis. ( 6867034 )
1983
31
Bloodmeal sources of Aedes triseriatus and Aedes vexans in a southern Wisconsin forest endemic for La Crosse encephalitis virus. ( 7072901 )
1982
32
Serological diagnosis of California (La Crosse) encephalitis by immunofluorescence. ( 1100666 )
1975
33
Diagnosis of California (La Crosse) encephalitis by precipitin techniques: a prospective study. ( 4216289 )
1974

Variations for La Crosse Encephalitis

Expression for La Crosse Encephalitis

Search GEO for disease gene expression data for La Crosse Encephalitis.

Pathways for La Crosse Encephalitis

Pathways related to La Crosse Encephalitis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 AXL GAS6 IFNB1 MERTK PAK6 TNFRSF10B
2
Show member pathways
13.01 AXL CXCL1 GAS6 MERTK PAK6 TNFRSF10B
3
Show member pathways
12.74 CXCL1 DDX58 IFNB1 IRF3 PAK6
4
Show member pathways
12.34 DDX58 IFNB1 IRF3 POLR2A TNFRSF10B
5
Show member pathways
11.95 GAS6 MERTK TNFRSF10B
6
Show member pathways
11.92 H2AFX IFNB1 TNFRSF10B
7
Show member pathways
11.91 GAS6 IFNB1 IRF3 POLR2A
8
Show member pathways
11.85 AXL GAS6 MERTK PAK6 TYRO3
9 11.73 DDX58 IFNB1 IRF3
10 11.43 AXL GAS6 MERTK TYRO3
11 10.96 CXCL1 IFNB1
12
Show member pathways
10.84 DDX58 IRF3
13 10 AXL CXCL1 GAS6 MERTK PAK6 TYRO3

GO Terms for La Crosse Encephalitis

Biological processes related to La Crosse Encephalitis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 spermatogenesis GO:0007283 9.96 AXL H2AFX MERTK TYRO3
2 viral process GO:0016032 9.88 AXL DDX58 GAS6 H2AFX IRF3 TYRO3
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.87 AXL GAS6 MERTK TYRO3
4 peptidyl-tyrosine phosphorylation GO:0018108 9.83 AXL MERTK TYRO3
5 cellular response to lipopolysaccharide GO:0071222 9.82 AXL CXCL1 IRF3
6 positive regulation of MAPK cascade GO:0043410 9.81 AXL MERTK TYRO3
7 negative regulation of signal transduction GO:0009968 9.81 AXL MERTK TYRO3
8 viral entry into host cell GO:0046718 9.77 AXL GAS6 TYRO3
9 platelet activation GO:0030168 9.73 AXL GAS6 MERTK TYRO3
10 phagocytosis GO:0006909 9.7 AXL GAS6 MERTK
11 substrate adhesion-dependent cell spreading GO:0034446 9.67 AXL MERTK TYRO3
12 negative regulation of type I interferon production GO:0032480 9.66 DDX58 IRF3
13 negative regulation of interferon-gamma production GO:0032689 9.65 AXL GAS6
14 positive regulation of interferon-beta production GO:0032728 9.64 DDX58 IRF3
15 cellular response to exogenous dsRNA GO:0071360 9.63 DDX58 IFNB1
16 response to exogenous dsRNA GO:0043330 9.63 DDX58 IFNB1 IRF3
17 negative regulation of cytokine production GO:0001818 9.62 AXL MERTK
18 positive regulation of interferon-alpha production GO:0032727 9.61 DDX58 IRF3
19 dendritic cell differentiation GO:0097028 9.61 AXL GAS6
20 cellular response to interferon-alpha GO:0035457 9.59 AXL GAS6
21 ovulation cycle GO:0042698 9.58 AXL TYRO3
22 positive regulation of cytokine-mediated signaling pathway GO:0001961 9.58 AXL GAS6
23 enzyme linked receptor protein signaling pathway GO:0007167 9.56 AXL GAS6
24 positive regulation of natural killer cell differentiation GO:0032825 9.55 AXL GAS6
25 negative regulation of dendritic cell apoptotic process GO:2000669 9.54 AXL GAS6
26 natural killer cell differentiation GO:0001779 9.54 AXL MERTK TYRO3
27 neutrophil clearance GO:0097350 9.51 AXL MERTK
28 secretion by cell GO:0032940 9.5 AXL MERTK TYRO3
29 forebrain cell migration GO:0021885 9.48 AXL TYRO3
30 protein kinase B signaling GO:0043491 9.46 AXL GAS6 MERTK TYRO3
31 vagina development GO:0060068 9.43 AXL MERTK TYRO3
32 negative regulation of lymphocyte activation GO:0051250 9.13 AXL MERTK TYRO3
33 apoptotic cell clearance GO:0043277 8.92 AXL GAS6 MERTK TYRO3
34 protein phosphorylation GO:0006468 10.02 AXL GAS6 MERTK PAK6 TYRO3

Molecular functions related to La Crosse Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.43 AXL MERTK TYRO3
2 phosphatidylinositol 3-kinase binding GO:0043548 9.16 AXL TYRO3
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 AXL MERTK TYRO3
4 Wnt-protein binding GO:0017147 8.8 AXL MERTK TYRO3

Sources for La Crosse Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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