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MCID: LCR004
MIFTS: 37

La Crosse Encephalitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for La Crosse Encephalitis

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MalaCards integrated aliases for La Crosse Encephalitis:

Name: La Crosse Encephalitis 12 52 58 3 15 71
California Encephalitis 12 52 32
Californian Encephalitis 52 58
Encephalitis, California 43 71
Neuroinvasive California Encephalitis Virus Infection 12
California Virus Encephalitis 12

Characteristics:

Orphanet epidemiological data:

58
la crosse encephalitis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Canada); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare neurological diseases
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050118
ICD9CM 34 062.5
MeSH 43 D004670
SNOMED-CT 67 418531007
ICD10 32 A83.5
MESH via Orphanet 44 D004670
ICD10 via Orphanet 33 A83.5
UMLS via Orphanet 72 C0014053
Orphanet 58 ORPHA83483
UMLS 71 C0014053 C0276379
Sources

Summaries for La Crosse Encephalitis

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NIH Rare Diseases : 52 La Crosse (LAC) encephalitis is a mosquito-borne virus that was first described in La Crosse, Wisconsin in 1963. Since then, it has been reported in several Midwestern and Mid-Atlantic states. The LAC virus is one of many mosquito-transmitted viruses that can cause an inflammation of the brain (encephalitis ). About 80-100 cases of this condition are reported each year in the United States. Most cases occur in children younger than age 16. While most people who become infected have no symptoms, those who do become ill may have fever, headache, vomiting and lethargy (tiredness). Severe cases develop encephalitis accompanied by seizures . Coma and paralysis occur in some cases. There is no specific treatment for LAC encephalitis. Supportive therapy is provided to those who develop severe cases of the disease.

MalaCards based summary : La Crosse Encephalitis, also known as california encephalitis, is related to autoimmune encephalitis and encephalitis, and has symptoms including seizures, fever and headache. An important gene associated with La Crosse Encephalitis is LGI1 (Leucine Rich Glioma Inactivated 1), and among its related pathways/superpathways are Tyrosine Kinases / Adaptors and G-protein signaling_Rap2B regulation pathway. Affiliated tissues include brain, testes and skin.

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain, has material basis in La Crosse virus, which is transmitted by treehole mosquito, Ochlerotatus triseriatus. The infection has symptom seizures, has symptom headache, has symptom fever, has symptom coma, and has symptom paralysis.

CDC : 3 La Crosse encephalitis is a viral disease spread to people by the bite of an infected mosquito. Most cases occur in the upper Midwestern, mid-Atlantic, and southeastern states. Many people infected have no apparent symptoms. Some of those who become ill develop severe neuroinvasive disease (disease that affects the nervous system). Severe disease often involves encephalitis (an inflammation of the brain) and can include seizures, coma, and paralysis. Severe disease occurs most often in children under the age of 16.

Wikipedia : 74 La Crosse encephalitis is an encephalitis caused by an arbovirus (the La Crosse virus) which has a... more...

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Related Diseases for La Crosse Encephalitis

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Diseases related to La Crosse Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 autoimmune encephalitis 30.4 LGI1 CNTNAP2
2 encephalitis 29.9 PNMA2 LGI1 DDX58 CNTNAP2 CD40LG
3 viral encephalitis 29.9 LGI1 DDX58 CD40LG
4 acute disseminated encephalomyelitis 29.7 LGI1 DPYSL5 CNTNAP2 CD40LG
5 viral infectious disease 28.6 RNASEL DDX58 CD40LG
6 autosomal dominant epilepsy with auditory features 10.4 LGI1 CNTNAP2
7 dissociative amnesia 10.4 LGI1 CNTNAP2
8 cerebellopontine angle meningioma 10.3 LGI1 DPYSL5
9 internuclear ophthalmoplegia 10.3 LGI1 DPYSL5
10 neuroretinitis 10.3 DPYSL5 CD40LG
11 plexopathy 10.3 DPYSL5 CD40LG
12 miller fisher syndrome 10.2 CNTNAP2 CD40LG
13 zika fever 10.2 TYRO3 CD40LG
14 cortical deafness 10.2 PNMA2 LGI1
15 mutism 10.2 LGI1 GRIN1 CNTNAP2
16 meningoencephalitis 10.2
17 herpes simplex encephalitis 10.2
18 choreatic disease 10.2 LGI1 DPYSL5 CNTNAP2
19 limbic encephalitis 10.1 PNMA2 LGI1
20 retinitis pigmentosa 38 10.1 TYRO3 MERTK
21 west nile encephalitis 10.1 RNASEL CD40LG
22 west nile fever 10.1 RNASEL CD40LG
23 paralytic poliomyelitis 10.1 RNASEL CD40LG
24 phlebotomus fever 10.1 MED8 CD40LG
25 herpes simplex 10.1
26 optic nerve disease 10.1 LGI1 DPYSL5 CD40LG
27 st. louis encephalitis 10.0
28 benign epilepsy with centrotemporal spikes 10.0 LGI1 GRIN1 CNTNAP2
29 spinal cord disease 10.0 LGI1 DPYSL5 CNTNAP2 CD40LG
30 whipple disease 10.0 PNMA2 DPYSL5 DPP6
31 lingual-facial-buccal dyskinesia 10.0 LGI1 GRIN1 DPYSL5 CNTNAP2
32 western equine encephalitis 10.0
33 bronchitis 10.0
34 von economo's disease 10.0 LGI1 DPYSL5 DPP6 CNTNAP2
35 stiff-person syndrome 9.9 LGI1 DPYSL5 DPP6 CNTNAP2
36 hyperekplexia 9.9 LGI1 DPYSL5 DPP6 CNTNAP2
37 mesangial proliferative glomerulonephritis 9.9 GAS6 CD40LG
38 ocular motor apraxia 9.9
39 west nile virus 9.9
40 chikungunya 9.9
41 aphasia 9.9
42 eastern equine encephalitis 9.9
43 aseptic meningitis 9.9
44 dengue disease 9.9
45 gastroenteritis 9.9
46 bacterial meningitis 9.9
47 croup 9.8 DDX58 CD40LG
48 anterograde amnesia 9.8 PNMA2 LGI1 DPYSL5 CNTNAP2
49 rocky mountain spotted fever 9.8
50 cysticercosis 9.8

Graphical network of the top 20 diseases related to La Crosse Encephalitis:



Diseases related to La Crosse Encephalitis
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Symptoms & Phenotypes for La Crosse Encephalitis

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Symptoms:

12
  • • seizures
  • • fever
  • • headache
  • • paralysis
  • • coma
Sources

Drugs & Therapeutics for La Crosse Encephalitis

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Search Clinical Trials , NIH Clinical Center for La Crosse Encephalitis

Cochrane evidence based reviews: encephalitis, california

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Genetic Tests for La Crosse Encephalitis

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Anatomical Context for La Crosse Encephalitis

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The Foundational Model of Anatomy Ontology organs/tissues related to La Crosse Encephalitis:

19
Brain

MalaCards organs/tissues related to La Crosse Encephalitis:

40
Brain, Testes, Skin, Temporal Lobe
Sources

Publications for La Crosse Encephalitis

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Articles related to La Crosse Encephalitis:

(show top 50) (show all 287)
# Title Authors PMID Year
1
Double Crossed: A Case of La Crosse Encephalitis. 61
32236166 2020
2
Prospective Cohort Study of Next-Generation Sequencing as a Diagnostic Modality for Unexplained Encephalitis in Children. 61
31107955 2019
3
Ongoing and emerging arbovirus threats in Europe. 61
30176404 2018
4
Notes from the Field: Spatially Associated Coincident and Noncoincident Cases of La Crosse Encephalitis - North Carolina, 2002-2017. 61
30286057 2018
5
Modeling a single season of Aedes albopictus populations based on host-seeking data in response to temperature and precipitation in eastern Tennessee. 61
29757517 2018
6
Serological surveillance for Tahyna virus (California encephalitis orthobunyavirus, Peribunyaviridae) neutralizing antibodies in wild ungulates in Austria, Hungary and Romania. 61
29516663 2018
7
Characterization of five unclassified orthobunyaviruses (Bunyaviridae) from Africa and the Americas. 61
28885138 2017
8
La Crosse Virus Vectors Are Host-Seeking and Ovipositing After 1700 H in Eastern Tennessee. 61
28854104 2017
9
Anti-N-Methyl-d-Aspartate Receptor Encephalitis Appearing as a New-Onset Psychosis: Disease Course in Children and Adolescents Within the California Encephalitis Project. 61
28506504 2017
10
Epidemiology of La Crosse Virus Emergence, Appalachia Region, United States. 61
27767009 2016
11
Rapid detection of European orthobunyaviruses by reverse transcription loop-mediated isothermal amplification assays. 61
27491341 2016
12
La Crosse Encephalitis: A Persistent Arboviral Threat in North Carolina. 61
27621342 2016
13
La Crosse Encephalitis: An Adult Case Series. 61
27086496 2016
14
A Genome-Wide RNA Interference Screen Identifies a Role for Wnt/β-Catenin Signaling during Rift Valley Fever Virus Infection. 61
27226375 2016
15
Serological Survey for Antibodies to Mosquito-Borne Bunyaviruses Among US National Park Service and US Forest Service Employees. 61
26855300 2016
16
The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. 61
26523970 2015
17
Genetic and Phylogenetic Characterization of Tataguine and Witwatersrand Viruses and Other Orthobunyaviruses of the Anopheles A, Capim, Guamá, Koongol, Mapputta, Tete, and Turlock Serogroups. 61
26610546 2015
18
Complete genome sequence of trivittatus virus. 61
26212363 2015
19
Neurological Outcomes After Presumed Childhood Encephalitis. 61
26220354 2015
20
La Crosse Encephalitis Virus Infection in Field-Collected Aedes albopictus, Aedes japonicus, and Aedes triseriatus in Tennessee. 61
26375904 2015
21
Epilepsy After Resolution of Presumed Childhood Encephalitis. 61
26092415 2015
22
Acute pediatric encephalitis neuroimaging: single-institution series as part of the California encephalitis project. 61
25846458 2015
23
Use of clinical and neuroimaging characteristics to distinguish temporal lobe herpes simplex encephalitis from its mimics. 61
25637586 2015
24
Cemeteries are effective sites for monitoring la crosse virus (LACv) and these environments may play a role in LACv infection. 61
25860584 2015
25
Insights into pediatric herpes simplex encephalitis from a cohort of 21 children from the California Encephalitis Project, 1998-2011. 61
24911898 2014
26
Isolation of Tahyna Virus (California Encephalitis Group) From Anopheles hyrcanus (Diptera, Culicidae), a Mosquito Species New to, and Expanding in, Central Europe. 61
26309316 2014
27
The role of continuous electroencephalography in childhood encephalitis. 61
24507696 2014
28
Isolation and characterization of a California encephalitis serogroup orthobunyavirus from Finnish mosquitoes. 61
24480054 2014
29
Arboviruses pathogenic for domestic and wild animals. 61
24751197 2014
30
Emerging trends in free-living amebic infections of the brain: implications for organ transplantation. 61
25073256 2013
31
Epidemiology, outcomes and predictors of recovery in childhood encephalitis: a hospital-based study. 61
23518823 2013
32
Encephalitis with thalamic and basal ganglia abnormalities: etiologies, neuroimaging, and potential role of respiratory viruses. 61
23196954 2013
33
Impacts of climate, land use, and biological invasion on the ecology of immature Aedes mosquitoes: implications for La Crosse emergence. 61
22692799 2012
34
La Crosse encephalitis surveillance using single versus paired serologic testing. 61
21848528 2012
35
[Molecular genetic analysis of Tahyna virus strains]. 61
22905424 2012
36
The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. 61
22281844 2012
37
A recombinant chimeric La Crosse virus expressing the surface glycoproteins of Jamestown Canyon virus is immunogenic and protective against challenge with either parental virus in mice or monkeys. 61
22013033 2012
38
Lack of association between childhood immunizations and encephalitis in California, 1998-2008. 61
22080172 2012
39
Safety and pharmacokinetics of ribavirin for the treatment of la crosse encephalitis. 61
21544005 2011
40
Tahyna virus genetics, infectivity, and immunogenicity in mice and monkeys. 61
21435229 2011
41
Varicella zoster disease of the central nervous system: epidemiological, clinical, and laboratory features 10 years after the introduction of the varicella vaccine. 61
21177308 2011
42
Interferon antagonist NSs of La Crosse virus triggers a DNA damage response-like degradation of transcribing RNA polymerase II. 61
21118815 2011
43
[Arborviruses of the California encephalitis serogroup 1N Russia and their contribution to infectious pathology]. 61
21786596 2011
44
[Characteristic of the new Khatanga virus genotype]. 61
21786597 2011
45
Anti-NMDA receptor encephalitis: report of ten cases and comparison with viral encephalitis. 61
19718525 2009
46
Human metapneumovirus associated with central nervous system infection in children. 61
19755929 2009
47
Under the radar: balamuthia amebic encephalitis. 61
19236272 2009
48
Cryptogenic New Onset Refractory Status Epilepticus (NORSE) in adults-Infectious or not? 61
19013586 2009
49
Possible congenital infection with La Crosse encephalitis virus--West Virginia, 2006-2007. 61
19145220 2009
50
Enterovirus-associated encephalitis in the California encephalitis project, 1998-2005. 61
18959496 2008
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Variations for La Crosse Encephalitis

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Expression for La Crosse Encephalitis

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Search GEO for disease gene expression data for La Crosse Encephalitis.
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Pathways for La Crosse Encephalitis

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Pathways related to La Crosse Encephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Tyrosine Kinases / Adaptors 4
10.97 TYRO3 MERTK GAS6
2
G-protein signaling_Rap2B regulation pathway 22
10.16 TYRO3 MERTK GAS6 CD40LG
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GO Terms for La Crosse Encephalitis

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Cellular components related to La Crosse Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synaptic cleft GO:0043083 8.62 LGI1 GRIN1

Biological processes related to La Crosse Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.76 TYRO3 MERTK LGI1 DPYSL5
2 platelet activation GO:0030168 9.61 TYRO3 MERTK CD40LG
3 phagocytosis GO:0006909 9.43 TYRO3 MERTK GAS6
4 natural killer cell differentiation GO:0001779 9.4 TYRO3 MERTK
5 vagina development GO:0060068 9.37 TYRO3 MERTK
6 secretion by cell GO:0032940 9.32 TYRO3 MERTK
7 negative regulation of lymphocyte activation GO:0051250 9.16 TYRO3 MERTK
8 protein kinase B signaling GO:0043491 9.13 TYRO3 MERTK GAS6
9 apoptotic cell clearance GO:0043277 8.8 TYRO3 MERTK GAS6

Molecular functions related to La Crosse Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.44 TYRO3 RNASEL PNMA2 MERTK MED8 LGI1
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Sources for La Crosse Encephalitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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