MCID: LBY004
MIFTS: 40

Labyrinthitis

Categories: Ear diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Labyrinthitis

MalaCards integrated aliases for Labyrinthitis:

Name: Labyrinthitis 12 77 45 15 17 74
Labyrinthine Disorder 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1468
ICD9CM 36 386.3 386.30
MeSH 45 D007762
SNOMED-CT 69 23919004
ICD10 34 H83.0 H83.09

Summaries for Labyrinthitis

Disease Ontology : 12 An otitis interna which involves inflammation of the labyrinths.

MalaCards based summary : Labyrinthitis, also known as labyrinthine disorder, is related to purulent labyrinthitis and focal labyrinthitis, and has symptoms including vertigo and earache. An important gene associated with Labyrinthitis is CRLF1 (Cytokine Receptor Like Factor 1). The drugs Histamine and Dimenhydrinate have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Labyrinthitis, also known as vestibular neuritis, is the inflammation of the inner ear. It results in a... more...

Related Diseases for Labyrinthitis

Diseases in the Labyrinthitis family:

Viral Labyrinthitis

Diseases related to Labyrinthitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 purulent labyrinthitis 12.5
2 focal labyrinthitis 12.5
3 viral labyrinthitis 12.4
4 toxic labyrinthitis 12.4
5 serous labyrinthitis 12.3
6 bilateral hyperactive labyrinth 12.1
7 unilateral hyperactive labyrinth 12.1
8 bilateral hypoactive labyrinth 12.1
9 unilateral hypoactive labyrinth 12.0
10 inner ear disease 11.8
11 meniere disease 11.5
12 otosclerosis 11.4
13 vestibular neuronitis 11.1
14 cochlear disease 11.1
15 otitis media 10.5
16 meningitis 10.5
17 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.4
18 sensorineural hearing loss 10.2
19 suppurative otitis media 10.2
20 vertigo, benign recurrent 10.1
21 mastoiditis 10.1
22 benign paroxysmal positional nystagmus 10.1
23 otosclerosis 1 10.1
24 mumps 10.1
25 facial paralysis 10.1
26 sudden sensorineural hearing loss 10.1
27 cholesteatoma of middle ear 10.0
28 neurilemmoma 10.0
29 pneumococcal meningitis 10.0
30 thrombosis 9.9
31 acoustic neuroma 9.9
32 dementia 9.9
33 chronic purulent otitis media 9.9
34 neuritis 9.9
35 herpes simplex 9.9
36 pathologic nystagmus 9.9
37 autoimmune inner ear disease 9.9
38 congenital cytomegalovirus 9.9
39 spondyloenchondrodysplasia 9.9
40 headache 9.9
41 autoimmune disease 9.8
42 popliteal pterygium syndrome 9.8
43 diabetes mellitus, noninsulin-dependent 9.8
44 lipomatosis, multiple 9.8
45 motion sickness 9.8
46 osteoporosis 9.8
47 raynaud disease 9.8
48 torticollis 9.8
49 osteoid osteoma 9.8
50 retinitis pigmentosa-deafness syndrome 9.8

Comorbidity relations with Labyrinthitis via Phenotypic Disease Network (PDN): (show all 22)


Anxiety Basilar Artery Insufficiency
Benign Essential Hypertension Bronchitis
Cerebrovascular Disease Chronic Myocardial Ischemia
Esophagitis Generalized Atherosclerosis
Hypertension, Essential Hypothyroidism
Inner Ear Disease Intermediate Coronary Syndrome
Ischemic Heart Disease Meniere Disease
Otitis Media Pathologic Nystagmus
Peripheral Vertigo Transient Cerebral Ischemia
Vertebral Artery Insufficiency Vertigo, Benign Recurrent
Vestibular Nystagmus Viral Labyrinthitis

Graphical network of the top 20 diseases related to Labyrinthitis:



Diseases related to Labyrinthitis

Symptoms & Phenotypes for Labyrinthitis

UMLS symptoms related to Labyrinthitis:


vertigo, earache

GenomeRNAi Phenotypes related to Labyrinthitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.17 IGBP1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.17 IGBP1 NCS1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.17 NCS1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.17 IGBP1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.17 IGBP1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.17 NCS1

Drugs & Therapeutics for Labyrinthitis

Drugs for Labyrinthitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 196)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4,Phase 3,Not Applicable 51-45-6 774
2
Dimenhydrinate Approved Phase 4,Phase 3 523-87-5 441281
3
Betahistine Approved, Investigational Phase 4,Not Applicable 5638-76-6 2366
4
Sodium Citrate Approved, Investigational Phase 4 68-04-2
5
Caffeine Approved Phase 4 58-08-2 2519
6
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
7
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
8
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
9
Tocopherol Approved, Investigational Phase 4 1406-66-2 14986
10
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
11
Thymol Approved Phase 4 89-83-8 6989
12
Ethanol Approved Phase 4 64-17-5 702
13
Glycerol Approved, Investigational Phase 4 56-81-5 753
14
Phenol Approved, Experimental Phase 4,Not Applicable 108-95-2 996
15
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3 2921-57-5
16
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
17
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
18
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3 302-25-0
19
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
20
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
21
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
22
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 1 7440-70-2 271
23
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
24
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
26
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
27
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
28 Tocotrienol Investigational Phase 4 6829-55-6
29
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Phase 3 2920-86-7
30
Histamine Phosphate Phase 4,Phase 3,Not Applicable 51-74-1 65513
31 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Histamine H1 Antagonists Phase 4,Phase 3,Not Applicable
33 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
34 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Histamine Antagonists Phase 4,Phase 3,Not Applicable
37 Antiemetics Phase 4,Phase 3,Phase 2,Not Applicable
38 Pharmaceutical Solutions Phase 4,Phase 2
39 Vasodilator Agents Phase 4,Phase 1,Not Applicable
40 Sildenafil Citrate Phase 4 171599-83-0
41 Phosphodiesterase Inhibitors Phase 4,Not Applicable
42 Citrate Phase 4
43 Phosphodiesterase 5 Inhibitors Phase 4
44 Central Nervous System Stimulants Phase 4
45 Purinergic P1 Receptor Antagonists Phase 4
46 Dopamine Antagonists Phase 4
47 Dopamine Agents Phase 4
48 Dopamine D2 Receptor Antagonists Phase 4
49 Trace Elements Phase 4
50 Vitamins Phase 4

Interventional clinical trials:

(show top 50) (show all 204)
# Name Status NCT ID Phase Drugs
1 Effects on the Diagnostic Accuracy of Magnetic Imaging Angiographies of the Supra-Aortic Vessels by Three Different Magnetic Resonance Contrast Agents in Patients Unknown status NCT00132223 Phase 4 Contrast agent
2 Isobide Solution and Meniace Tablets Compared to Monotherapy With Meniace Tablets Completed NCT02718846 Phase 4 Meniace;Isobide
3 Efficacy of Local Overpressure Treatment for Meniere's Disease Completed NCT00831688 Phase 4
4 Effects of Betaserc on Vestibular Compensation in Patients Suffering From Disabling Meniere's Disease and Having Undergone Vestibular Neurotomy Completed NCT00160238 Phase 4 Betahistine 24 mg bid (Betaserc)
5 Sildenafil For Meniere's Disease Completed NCT00145483 Phase 4 Sildenafil
6 Effect of Caffeine Intake in Vestibular Function Completed NCT02825199 Phase 4
7 Comparison of Efficacy Between Piracetam and Dimenhydrinate in Patients With Peripheral Vertigo Completed NCT01890538 Phase 4 Administration of 100 mg dimenhydrinate intravenous;2 g piracetam intravenous
8 Comparison of Efficacy Dimenhydrinate and Metoclopramide in the Treatment of Nausea Due to Vertigo Completed NCT02253524 Phase 4 Dimenhydrinate;Metoclopramide
9 Efficacy of Vitamin D and Calcium Supplementation on the Prevention of Recurrences in BPPV Completed NCT02031692 Phase 4 400IU cholecalciferol and 500mg of elemental calcium as calcium carbonate
10 Effect of Stellate Ganglion Block on Meniere's Disease Completed NCT01574313 Phase 4 0.25mg, fludiazine;25mg cephadol@ (diphenidol);200mg kentons@ (tocopherol nicotinate).
11 Chlorobutanol, Potassium Carbonate, and Irrigation in Cerumen Removal Completed NCT00765635 Phase 4 drops intilation (Taponoto ® );drops intilation (Otocerum®);drops intilation (Placebo)
12 Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Patients With Meniere's Disease Recruiting NCT02530931 Phase 4 Gadolinium
13 Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Healthy Subjects (HYDROPS) Recruiting NCT02529475 Phase 4 Gadoteric acid
14 Acute Unilateral Vestibulopathy and Corticosteroid Treatment Recruiting NCT02912182 Phase 4 Betamethasone;Placebo;Prednisolone
15 A Study To Evaluate The Efficacy And Safety Of Betahistine Mesilate In The Treatment Of Patients With Vertigo Caused By Cerebral Infarction In Posterior Circulation Withdrawn NCT00474409 Phase 4 Merislon
16 Non Inferiority of Meclin® (Meclizine Chlorhydrate) Versus Dramin® (Dimenhydrinate) in Control of Acute Vertigo Symptoms From Peripheral Origin Unknown status NCT02112578 Phase 3 Meclizine;Dimenhydrinate
17 Efficacy of Antiviral Medications in Controlling Vertigo Attacks of Patients With Meniere's Disease Unknown status NCT01729767 Phase 2, Phase 3 Acyclovir;Placebo
18 Conventional Versus Virtual Reality Based Vestibular Rehabilitation Completed NCT01442623 Phase 2, Phase 3
19 Study of OTO-104 in Subjects With Unilateral Meniere's Disease Completed NCT02612337 Phase 3 OTO-104;Placebo
20 Clinical Trial of Traditional Chinese Diaoshi Jifa Therapy of Meniere's Disease Completed NCT01454726 Phase 3
21 Transtympanic Gentamicin vs. Steroids in Refractory Meniere's Disease Completed NCT00802529 Phase 2, Phase 3 Methylprednisolone;Gentamicin
22 Study of Lamotrigine to Treat Ménière's Disease Completed NCT02158585 Phase 3 Lamotrigine;Placebo
23 The Treatment of Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo Completed NCT02029508 Phase 3
24 Promethazine vs. Lorazepam for Treatment of Vertigo Completed NCT01827293 Phase 3 Promethazine;Lorazepam
25 Treatment of Geotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT01366430 Phase 3
26 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT00810641 Phase 3
27 Canalith Repositioning Procedure for BPPV in Primary Care Completed NCT00182273 Phase 3
28 Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria Completed NCT00785135 Phase 3
29 Phase 3 Study of OTO-104 in Subjects With Unilateral Meniere's Disease Recruiting NCT03664674 Phase 3 OTO-104;Placebo
30 Rizatriptan for Episodic Dizziness in Vestibular Migraine Recruiting NCT02447991 Phase 2, Phase 3 Rizatriptan;Placebo
31 Caroverin and Inner Ear Diseases Suspended NCT01174979 Phase 3 Caroverin
32 Autoimmunity in Inner Ear Disease Terminated NCT00000361 Phase 3 Corticosteroids;Methotrexate
33 A 6-Month Extension Study of OTO-104 in Meniere's Disease Terminated NCT02768662 Phase 3 OTO-104
34 Study of OTO-104 in Subjects With Unilateral Meniere's Disease Terminated NCT02717442 Phase 3 OTO-104;Placebo
35 A 6-Month Extension Study of OTO-104 in Meniere's Disease Terminated NCT02706730 Phase 3 OTO-104
36 Famvir for Treatment of Hearing in Unilateral Meniere's Disease Terminated NCT01526408 Phase 3 Famciclovir;Placebo
37 Latanoprost for the Treatment of Menière's Disease Unknown status NCT01973114 Phase 2 Latanoprost
38 Visual Feedback Goggle for Positional Vertigo Treatment Unknown status NCT00729885 Phase 1, Phase 2
39 Efficacy of Extended-release, Once Daily Tramadol for Post Operative Analgesia in Shoulder Arthroscopy Unknown status NCT02247648 Phase 2 tramadol;Placebo
40 The Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01950312 Phase 2 gevokizumab
41 A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease Completed NCT01267994 Phase 1, Phase 2 Anakinra
42 Study to Evaluate SPI-1005 in Adults With Meniere's Disease Completed NCT02603081 Phase 1, Phase 2 SPI-1005
43 A 1-Year Safety Study of OTO-104 in Subjects With Unilateral Meniere's Disease Located in United Kingdom Completed NCT02265393 Phase 2 OTO-104;Placebo
44 OTO-104 for the Treatment of Meniere's Disease Completed NCT01412177 Phase 2 OTO-104;Placebo
45 A Clinical Trial To Evaluate Efficacy And Safety Of Levophencynonate Hydrochloride In Patient With Vertigo Completed NCT02299804 Phase 2 Levophencynonate Hydrochloric;Placebo
46 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT02046980 Phase 2
47 Effect of V0251 in Acute Vertigo Completed NCT01583738 Phase 2 V0251;placebo
48 Prednisone Treatment for Vestibular Neuronitis Completed NCT00271791 Phase 2 Prednisone;Prednisone
49 Treatments for Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT00000359 Phase 2
50 A Trial of Booklet Based Self Management of Dizziness Completed NCT00732797 Phase 2

Search NIH Clinical Center for Labyrinthitis

Cochrane evidence based reviews: labyrinthitis

Genetic Tests for Labyrinthitis

Anatomical Context for Labyrinthitis

MalaCards organs/tissues related to Labyrinthitis:

42
Testes, Eye, Brain, Bone, Kidney, Pons, Bone Marrow

Publications for Labyrinthitis

Articles related to Labyrinthitis:

(show top 50) (show all 219)
# Title Authors Year
1
Pathology in Practice. Opportunistic Pseudomonas aeruginosa infection as cause of otitis media and labyrinthitis in immunocompetent mice. ( 30605387 )
2019
2
A case of external auditory canal osteoma complicated with cholesteatoma, mastoiditis, labyrinthitis and internal auditory canal pachymeningitis. ( 30745589 )
2019
3
Etiology-Specific Mineralization Patterns in Patients with Labyrinthitis Ossificans. ( 30792250 )
2019
4
Direction-Changing Positional Nystagmus in Acute Otitis Media Complicated by Serous Labyrinthitis: New Insights into Positional Nystagmus. ( 30870366 )
2019
5
Labyrinthitis Ossificans in a Cynomolgus Macaque (Macaca fascicularis). ( 29650059 )
2018
6
Differentiation Between Intralabyrinthine Schwannoma and Contrast-enhancing Labyrinthitis on MRI: Quantitative Analysis of Signal Intensity Characteristics. ( 30020263 )
2018
7
Gradenigo's Syndrome and Labyrinthitis: Conservative versus Surgical Treatment. ( 30155332 )
2018
8
Facial Nerve Stimulation Patterns Associated With Cochlear Implantation in Labyrinthitis Ossificans. ( 30444844 )
2018
9
"Emergency" Cochlear Implantation in Labyrinthitis Ossificans Secondary to Polyarteritis Nodosa: How to Face a Rare Entity. ( 30541729 )
2018
10
Cochlear Implant Associated Labyrinthitis: A Previously Unrecognized Phenomenon With a Distinct Clinical and Electrophysiological Impedance Pattern. ( 29065095 )
2017
11
Kawasaki Disease and Labyrinthitis: An Underdiagnosed Complication. ( 28417110 )
2017
12
Deterioration of Vestibular Cells in Labyrinthitis. ( 27881797 )
2017
13
Nystagmus in patients with unilateral acute otitis media complicated by serous labyrinthitis. ( 26797398 )
2016
14
Quantitative Assessment of Cochlear Histopathologic Findings in Patients With Suppurative Labyrinthitis. ( 26987015 )
2016
15
Labyrinthitis ossificans after meningitis: Superiority of high-resolution magnetic resonance imaging in demonstration of disease extent compared to high-resolution computed tomography. ( 27114680 )
2016
16
Pathologic Findings of the Cochlea in Labyrinthitis Ossificans Associated with the Round Window Membrane. ( 27221575 )
2016
17
Suppurative labyrinthitis associated with otitis media: 26 years' experience. ( 26718959 )
2016
18
Pneumolabyrinth with Labyrinthitis as the Suspected Cause. ( 27115607 )
2016
19
Cochlear changes in serous labyrinthitis associated with silent otitis media: A human temporal bone study. ( 26954857 )
2016
20
Progression of autoimmune inner ear disease to labyrinthitis ossificans: clinical and radiologic correlation. ( 25738715 )
2015
21
Rapidly Destructive Autoimmune Labyrinthitis Associated With Ulcerative Colitis. ( 26385058 )
2015
22
The Impact of Postmeningitic Labyrinthitis Ossificans on Speech Performance After Pediatric Cochlear Implantation. ( 26536413 )
2015
23
Labyrinthitis Ossificans: On the Mechanism of Perilabyrinthine Bone Remodeling. ( 25757630 )
2015
24
Refractory Positional Vertigo With Apogeotropic Horizontal Nystagmus After Labyrinthitis: Surgical Treatment and Identification of Dysmorphic Ampullae. ( 26208126 )
2015
25
The incidence of tympanogenic labyrinthitis ossificans. ( 25075947 )
2014
26
Bilateral sensorineural hearing loss and labyrinthitis ossificans secondary to neurosarcoidosis. ( 25189997 )
2014
27
Clinical outcome after cochlear implantation in patients with unilateral hearing loss due to labyrinthitis ossificans. ( 23921941 )
2013
28
High-resolution 3-D T2-weighted imaging in the diagnosis of labyrinthitis ossificans: emphasis on subtle cochlear involvement. ( 23843131 )
2013
29
Labyrinthitis ossificans in a cochlear implant patient with Usher syndrome. ( 23455060 )
2013
30
Tuberculous otitis media with facial paralysis combined with labyrinthitis. ( 24653900 )
2013
31
End-stage labyrinthitis with extensive erosion of the bony labyrinth. ( 22377652 )
2012
32
Acute labyrinthitis secondary to aural tick infestation. ( 23077807 )
2012
33
Effect of Ginkgo biloba extract on endotoxin-induced labyrinthitis. ( 21592590 )
2011
34
Auditory and vestibular defects induced by experimental labyrinthitis following herpes simplex virus in mice. ( 21526906 )
2011
35
Radiology quiz case 2. Labyrinthitis ossificans secondary to suppurative labyrinthitis. ( 21422319 )
2011
36
Deafness due to haemorrhagic labyrinthitis and a review of relapses in Streptococcus suis meningitis. ( 20358139 )
2010
37
Labyrinthitis ossificans secondary to autoimmune inner ear disease: a previously unreported condition. ( 20416474 )
2010
38
Labyrinthitis ossificans. ( 19300296 )
2009
39
Labyrinthitis ossificans in a child with sickle cell disease: CT and MRI findings. ( 19415252 )
2009
40
Posttraumatic labyrinthitis ossificans with perilymphatic fistulization. ( 19862674 )
2009
41
Labyrinthitis ossificans: how accurate is MRI in predicting cochlear obstruction? ( 19393413 )
2009
42
Serous labyrinthitis as a manifestation of cat scratch disease: a case report. ( 20519021 )
2009
43
Meningitis resulting in hearing loss and labyrinthitis ossificans - does the causative organism matter? ( 18246540 )
2008
44
Induction of cytomegalovirus-infected labyrinthitis in newborn mice by lipopolysaccharide: a model for hearing loss in congenital CMV infection. ( 18475257 )
2008
45
Nitrogen and oxygen molecules in meningitis-associated labyrinthitis and hearing impairment. ( 18084715 )
2008
46
Labyrinthitis related to Wegener granulomatosis: magnetic resonance imaging findings. ( 18097336 )
2008
47
Progressive cochleo-vestibular labyrinthitis. ( 17633668 )
2007
48
Advancement in post-meningitic lateral semicircular canal labyrinthitis ossificans. ( 17123454 )
2007
49
Otogenic cerebellar abscess due to purulent labyrinthitis and defect of the superior semicircular canal and its propagation through the endolymphatic sac. ( 17372752 )
2007
50
Pathogenesis of cytomegalovirus-associated labyrinthitis in a guinea pig model. ( 17208485 )
2007

Variations for Labyrinthitis

Expression for Labyrinthitis

Search GEO for disease gene expression data for Labyrinthitis.

Pathways for Labyrinthitis

GO Terms for Labyrinthitis

Sources for Labyrinthitis

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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35 ICD10 via Orphanet
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70 SNOMED-CT via HPO
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72 TGDB
73 Tocris
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75 UMLS via Orphanet
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