MCID: LBY004
MIFTS: 43

Labyrinthitis

Categories: Ear diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Labyrinthitis

MalaCards integrated aliases for Labyrinthitis:

Name: Labyrinthitis 12 74 43 15 17 71 32
Labyrinthine Disorder 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1468
ICD9CM 34 386.3 386.30
MeSH 43 D007762
SNOMED-CT 67 23919004
ICD10 32 H83.0 H83.09
UMLS 71 C0022890 C0022893

Summaries for Labyrinthitis

Disease Ontology : 12 An otitis interna which involves inflammation of the labyrinths.

MalaCards based summary : Labyrinthitis, also known as labyrinthine disorder, is related to purulent labyrinthitis and viral labyrinthitis, and has symptoms including vertigo and earache. An important gene associated with Labyrinthitis is LUC7L2 (LUC7 Like 2, Pre-MRNA Splicing Factor). The drugs Pharmaceutical Solutions and Interleukin 1 Receptor Antagonist Protein have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and brain, and related phenotype is hearing/vestibular/ear.

Wikipedia : 74 Labyrinthitis, also known as vestibular neuritis, is the inflammation of the inner ear. Vestibular... more...

Related Diseases for Labyrinthitis

Diseases in the Labyrinthitis family:

Viral Labyrinthitis

Diseases related to Labyrinthitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 347)
# Related Disease Score Top Affiliating Genes
1 purulent labyrinthitis 34.2 GJB6 GJB2
2 viral labyrinthitis 33.8 GJB6 GJB2 ATOH1
3 inner ear disease 31.8 SLC26A4 MYO7A GJB6 GJB2 COCH
4 branchiootic syndrome 1 30.7 SLC26A4 MYO7A GJB2
5 chronic purulent otitis media 30.6 PATE1 COCH
6 congenital cytomegalovirus 30.5 GJB6 GJB2
7 otosclerosis 30.4 SLC26A4 POLR1C GJB6 GJB2 CRLF1 COCH
8 cogan syndrome 30.3 GJB2 COCH
9 superior semicircular canal dehiscence 30.0 PATE1 CRLF1 COCH
10 sensorineural hearing loss 29.3 SLC26A4 MYO7A GJB6 GJB2 COCH ATOH1
11 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 28.7 SLC26A4 MYO7A GJB6 GJB2 COCH
12 usher syndrome 28.7 SLC26A4 MYO7A GJB6 GJB2 COCH
13 vestibular disease 28.7 SLC26A4 MYO7A GJB6 GJB2 CRLF1 COCH
14 auditory system disease 28.5 SLC26A4 MYO7A GJB6 GJB2 COCH ATOH1
15 focal labyrinthitis 12.6
16 toxic labyrinthitis 12.6
17 serous labyrinthitis 12.4
18 bilateral hyperactive labyrinth 12.2
19 unilateral hyperactive labyrinth 12.2
20 bilateral hypoactive labyrinth 12.2
21 unilateral hypoactive labyrinth 12.1
22 vestibular neuronitis 11.7
23 meniere disease 11.6
24 cochlear disease 11.2
25 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.7
26 otitis media 10.6
27 pathologic nystagmus 10.6
28 meningitis 10.6
29 cholesteatoma of middle ear 10.4
30 suppurative otitis media 10.4
31 bacterial meningitis 10.4
32 non-syndromic genetic deafness 10.3 GJB2 COCH
33 deafness, autosomal dominant 1 10.3 MYO7A GJB2
34 benign paroxysmal positional nystagmus 10.3
35 perilymphatic fistula 10.3
36 deafness, autosomal recessive 3 10.3 MYO7A GJB2
37 deafness, autosomal dominant 2a 10.3 GJB2 COCH
38 neuritis 10.3
39 pneumococcal meningitis 10.3
40 mumps 10.2
41 deafness, autosomal recessive 91 10.2 GJB2 COCH
42 nonsyndromic hearing loss and deafness, dfna3 10.2 GJB6 GJB2
43 nonsyndromic hearing loss and deafness, dfnb1 10.2 GJB6 GJB2
44 deafness, autosomal dominant 24 10.2 GJB6 GJB2
45 facial paralysis 10.2
46 neurilemmoma 10.2
47 pseudoainhum 10.2 GJB6 GJB2
48 deafness, autosomal recessive 1b 10.2 GJB6 GJB2
49 deafness, x-linked 2 10.2 GJB6 GJB2
50 autoimmune disease 10.2

Comorbidity relations with Labyrinthitis via Phenotypic Disease Network (PDN): (show all 20)


Anxiety Basilar Artery Insufficiency
Benign Essential Hypertension Bronchitis
Cerebrovascular Disease Esophagitis
Generalized Atherosclerosis Hypertension, Essential
Hypothyroidism Inner Ear Disease
Intermediate Coronary Syndrome Meniere Disease
Otitis Media Pathologic Nystagmus
Peripheral Vertigo Transient Cerebral Ischemia
Vertebral Artery Insufficiency Vertigo, Benign Recurrent
Vestibular Nystagmus Viral Labyrinthitis

Graphical network of the top 20 diseases related to Labyrinthitis:



Diseases related to Labyrinthitis

Symptoms & Phenotypes for Labyrinthitis

UMLS symptoms related to Labyrinthitis:


vertigo, earache

MGI Mouse Phenotypes related to Labyrinthitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.17 ATOH1 COCH FAM107B GJB2 GJB6 MYO7A

Drugs & Therapeutics for Labyrinthitis

Drugs for Labyrinthitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 2
2 Interleukin 1 Receptor Antagonist Protein Phase 2
3 Antirheumatic Agents Phase 2
4 Antibodies, Monoclonal Phase 1, Phase 2
5 Immunologic Factors Phase 1, Phase 2
6 Immunoglobulins Phase 1, Phase 2
7 Antibodies Phase 1, Phase 2
8 Gentamicins

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 An Open-label Study of the Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01950312 Phase 2 gevokizumab
2 A Phase I/II Open-label Study of the Effects of Anakinra in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01267994 Phase 1, Phase 2 Anakinra
3 A Phase II Placebo Controlled Study of the Effects of Anakinra (Kineret) in Subjects With Autoimmune Inner Ear Disease Disease (AIED) Recruiting NCT03587701 Phase 2 Anakinra 100Mg/0.67Ml Inj Syringe (Period 1);Placebo injection (Period 1);Anakinra 100Mg/0.67Ml Inj Syringe (Period 2);Placebo injection (Period 2)
4 Safety and Efficacy of Intratympanically Delivered Golimumab for Stabilization of Hearing in Patients With Autoimmune Inner Ear Disease: An Open-label Proof-of-concept Clinical Trial Terminated NCT01526174 Phase 1, Phase 2 Golimumab
5 A Randomised Double Blind, Multiple Dose, Pharmacokinetic and Safety Study of SENS 401 in Healthy Subjects Completed NCT03071003 Phase 1 SENS-401;Placebo
6 An Open-label, Single-dose, Pharmacokinetic Study of SENS-218 in Healthy Adult, Caucasian Subjects. Completed NCT02772796 Phase 1 SENS-218
7 The Use of Virtual Reality for the Treatment of Visual Vertigo. Unknown status NCT03020654
8 Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) Alone or in Combination on Balance and Visual Function in Individuals With Vertigo and Somatic Dysfunction Completed NCT01529151
9 Unilateral Peripheral Vestibular Dysfunction: Reeducation and Spatial Orientation. Completed NCT03171181
10 Clinical Trial Evaluation of a Sensory Enrichment Multimodal Device (SEMD) on Physical Therapy Patients With Disequilibrium Completed NCT01483937
11 Energy Demand in a Video Game Active Session and Potencial to Promove Post Exercise Hypotension in Hypertensive Women Completed NCT02924012
12 Single Session of Active Video Game Promotes Post Exercise Hypotension in Middle-aged Hypertensive Completed NCT02578485
13 Maintaining Cochlear Patency After VIIIth Nerve Surgery Recruiting NCT03261726
14 First-in-Human Early Feasibility Study of Safety, Tolerability and Efficacy for a Multichannel Vestibular Implant in Individuals With Bilateral Severe-to-Profound Loss of Vestibular Sensation Recruiting NCT02725463
15 CNS Infections Effect on the Inner Ear Recruiting NCT03715569
16 Vestibular Function in Cochlear Implanted Hearing Impaired Children Not yet recruiting NCT03599804
17 Role of Multislice Computed Tomography and Magnetic Resonance Imaging in Preoperative Cochlear Implant Evaluation Not yet recruiting NCT04131439

Search NIH Clinical Center for Labyrinthitis

Cochrane evidence based reviews: labyrinthitis

Genetic Tests for Labyrinthitis

Anatomical Context for Labyrinthitis

MalaCards organs/tissues related to Labyrinthitis:

40
Bone, Eye, Brain, Liver, Testes, Kidney, Myeloid

Publications for Labyrinthitis

Articles related to Labyrinthitis:

(show top 50) (show all 762)
# Title Authors PMID Year
1
Evolution of Cochlear implant mapping and vestibular function in a pediatric case of Labyrinthitis. 61
32024552 2020
2
Value of Routine Magnetic Resonance Imaging for the Preoperative Assessment of Cochlear Implant Candidates. 61
31911872 2019
3
Plinia cauliflora (Mart.) Kausel: A comprehensive ethnopharmacological review of a genuinely Brazilian species. 61
31425732 2019
4
Dizziness demystified. 61
31326945 2019
5
The impact of etiology and duration of deafness on speech perception outcomes in SSD patients. 61
31535291 2019
6
The prognostic value and pathophysiologic significance of three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) magnetic resonance imaging in idiopathic sudden sensorineural hearing loss: A systematic review and meta-analysis. 61
31532907 2019
7
A case of external auditory canal osteoma complicated with cholesteatoma, mastoiditis, labyrinthitis and internal auditory canal pachymeningitis. 61
30745589 2019
8
Human Otopathology of Cochlear Implant Drill-out Procedures. 61
31060442 2019
9
Imaging of temporal bone inflammations in children: a pictorial review. 61
31321462 2019
10
[Vertigo in children´╝Ücomposition and clinical characteristics]. 61
31163516 2019
11
Surveillance of antibiotic sensitivity pattern in chronic suppurative otitis media of an Indian teaching hospital. 61
31334487 2019
12
Direction-Changing Positional Nystagmus in Acute Otitis Media Complicated by Serous Labyrinthitis: New Insights into Positional Nystagmus. 61
30870366 2019
13
Not 'just' a foreign body in the ear canal. 61
31036742 2019
14
"Emergency" Cochlear Implantation in Labyrinthitis Ossificans Secondary to Polyarteritis Nodosa: How to Face a Rare Entity. 61
30541729 2019
15
Etiology-Specific Mineralization Patterns in Patients with Labyrinthitis Ossificans. 61
30792250 2019
16
Cochlear implant in Thalassemia patient - Case report. 61
30232935 2019
17
Pathology in Practice. Opportunistic Pseudomonas aeruginosa infection as cause of otitis media and labyrinthitis in immunocompetent mice. 61
30605387 2019
18
Facial Nerve Stimulation Patterns Associated With Cochlear Implantation in Labyrinthitis Ossificans. 61
30444844 2018
19
Spontaneous Labyrinthine Hemorrhage: A Case Series. 61
29966483 2018
20
Postoperative MR imaging features after superior semicircular canal plugging in Minor syndrome. 61
30220585 2018
21
Cochlear implantation in children with meningitis related deafness: The influence of electrode impedance and implant charge on auditory performance - A case control study. 61
30173965 2018
22
Acute Otitis Media and Associated Complications in United States Emergency Departments. 61
30113560 2018
23
Differentiation Between Intralabyrinthine Schwannoma and Contrast-enhancing Labyrinthitis on MRI: Quantitative Analysis of Signal Intensity Characteristics. 61
30020263 2018
24
The first report of human meningitis and pyogenic ventriculitis caused by Streptococcus suis: A case report. 61
29429850 2018
25
Epidemiology of Vestibular Impairments in a Pediatric Population. 61
30038452 2018
26
[Otitis media: definition, pathogenesis, clinical presentation, diagnosis and therapy]. 61
29986368 2018
27
[Classification of acute vestibular syndrome]. 61
29921051 2018
28
Labyrinthitis Ossificans in a Cynomolgus Macaque (Macaca fascicularis). 61
29650059 2018
29
Labyrinthine Sequestrum: A Case Report and Review of the Literature. 61
29337715 2018
30
Gradenigo's Syndrome and Labyrinthitis: Conservative versus Surgical Treatment. 61
30155332 2018
31
Feasibility of magnetic resonance imaging in the differential diagnosis of isolated acute audiovestibular loss. 61
30856134 2018
32
Social representation of elderly people on falls: structural analysis and in the light of Neuman. 61
29791623 2018
33
Cochlear Implant Associated Labyrinthitis: A Previously Unrecognized Phenomenon With a Distinct Clinical and Electrophysiological Impedance Pattern. 61
29065095 2017
34
Characteristic MR findings suggesting presumed labyrinthine hemorrhage. 61
28826288 2017
35
[How to manage vertigo in adult?] 61
29089218 2017
36
The Differential Diagnosis of Vertigo in Children: A Systematic Review of 2726 Cases. 61
29095392 2017
37
Pediatric Langerhans cell histiocytosis of the lateral skull base. 61
28688556 2017
38
Natural killer cells attenuate cytomegalovirus-induced hearing loss in mice. 61
28859161 2017
39
Radiological requirements for surgical planning in cochlear implant candidates. 61
29089672 2017
40
Hearing loss in patients with extracranial complications of chronic otitis media. 61
28541245 2017
41
Bilateral Labyrinthine and Internal Auditory Canal Enhancement in an Infant With Severe Labyrinthine Dysplasia: A Previously Unreported Phenomenon. 61
28346292 2017
42
Pediatric Acute Otitis Media in the Era of Pneumococcal Vaccination. 61
28349737 2017
43
Kawasaki Disease and Labyrinthitis: An Underdiagnosed Complication. 61
28417110 2017
44
Improvement in imaging common temporal bone pathologies at 3 T MRI: small structures benefit from a small field of view. 61
28034444 2017
45
Surveillance of bacteria Pseudomonas aeruginosa and MRSA associated with chronic suppurative otitis media. 61
27177975 2017
46
Hearing Preservation After Penetrating Cochlear Injury. 61
27866146 2017
47
Deterioration of Vestibular Cells in Labyrinthitis. 61
27881797 2017
48
Current diagnostic procedures for diagnosing vertigo and dizziness. 61
29279722 2017
49
Histopathology of the Human Inner Ear in the Cogan Syndrome with Cochlear Implantation. 61
28848089 2017
50
Sudden sensorineural hearing loss associated with inner ear lesions detected by magnetic resonance imaging. 61
28977031 2017

Variations for Labyrinthitis

Expression for Labyrinthitis

Search GEO for disease gene expression data for Labyrinthitis.

Pathways for Labyrinthitis

GO Terms for Labyrinthitis

Cellular components related to Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 8.96 GJB6 GJB2
2 connexin complex GO:0005922 8.62 GJB6 GJB2

Biological processes related to Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.61 TNFRSF1B GJB6 GJB2
2 response to lipopolysaccharide GO:0032496 9.58 TNFRSF1B GJB6 GJB2
3 gap junction assembly GO:0016264 9.37 GJB6 GJB2
4 inner ear auditory receptor cell differentiation GO:0042491 9.32 MYO7A ATOH1
5 cell communication by electrical coupling GO:0010644 9.26 GJB6 GJB2
6 inner ear development GO:0048839 9.26 MYO7A GJB6 GJB2 ATOH1
7 gap junction-mediated intercellular transport GO:1990349 9.16 GJB6 GJB2
8 sensory perception of sound GO:0007605 9.02 SLC26A4 MYO7A GJB6 GJB2 COCH

Molecular functions related to Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction channel activity GO:0005243 8.96 GJB6 GJB2
2 gap junction channel activity involved in cell communication by electrical coupling GO:1903763 8.62 GJB6 GJB2

Sources for Labyrinthitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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