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MCID: LBY004
MIFTS: 42

Labyrinthitis

Categories: Ear diseases, Infectious diseases, Neuronal diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Labyrinthitis

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MalaCards integrated aliases for Labyrinthitis:

Name: Labyrinthitis 12 74 43 15 17 71 32
Labyrinthine Disorder 71

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Ear diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1468
ICD9CM 34 386.3
MeSH 43 D007762
SNOMED-CT 67 23919004
ICD10 32 H83.0
UMLS 71 C0022890 C0022893
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Summaries for Labyrinthitis

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Disease Ontology : 12 An otitis interna which involves inflammation of the labyrinths.

MalaCards based summary : Labyrinthitis, also known as labyrinthine disorder, is related to purulent labyrinthitis and viral labyrinthitis, and has symptoms including vertigo and earache. An important gene associated with Labyrinthitis is LUC7L2 (LUC7 Like 2, Pre-MRNA Splicing Factor). The drugs Pharmaceutical Solutions and Interleukin 1 Receptor Antagonist Protein have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and testes, and related phenotype is hearing/vestibular/ear.

Wikipedia : 74 Labyrinthitis, also known as vestibular neuritis, is the inflammation of the inner ear. Vestibular... more...

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Related Diseases for Labyrinthitis

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Diseases in the Labyrinthitis family:

Viral Labyrinthitis

Diseases related to Labyrinthitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 345)
# Related Disease Score Top Affiliating Genes
1 purulent labyrinthitis 34.4 NF2 GJB2
2 viral labyrinthitis 33.5 GJB2 FAM107B ATOH1
3 vestibular neuronitis 32.8 FAM107B CRLF1
4 inner ear disease 32.3 SLC26A4 MYO7A GJB2
5 serous labyrinthitis 32.2 SLC26A4 PATE1 NF2 GJB2 ATOH1
6 otosclerosis 31.2 SLC26A4 SALL1 NF2 GJB2 CRLF1
7 facial paralysis 30.4 NF2 CRLF1
8 branchiootic syndrome 1 30.4 SLC26A4 MYO7A GJB2
9 acoustic neuroma 30.0 NF2 CRLF1
10 sensorineural hearing loss 29.4 SLC26A4 MYO7A GJB2 ATOH1
11 usher syndrome 29.3 SLC26A4 MYO7A GJB2
12 vestibular disease 29.3 SLC26A4 MYO7A GJB2 CRLF1
13 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 29.3 SLC26A4 MYO7A GJB2
14 auditory system disease 28.8 SLC26A4 MYO7A GJB2 ATOH1
15 focal labyrinthitis 12.6
16 toxic labyrinthitis 12.6
17 bilateral hyperactive labyrinth 12.2
18 unilateral hyperactive labyrinth 12.2
19 bilateral hypoactive labyrinth 12.2
20 unilateral hypoactive labyrinth 12.2
21 meniere disease 11.6
22 cochlear disease 11.2
23 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.7
24 otitis media 10.6
25 pathologic nystagmus 10.6
26 meningitis 10.6
27 cholesteatoma of middle ear 10.4
28 suppurative otitis media 10.4
29 bacterial meningitis 10.4
30 pediatric meningioma 10.3 NF2 LUC7L2
31 neurilemmoma of the fifth cranial nerve 10.3 NF2 CRLF1
32 trigeminal nerve neoplasm 10.3 NF2 CRLF1
33 glossopharyngeal nerve disease 10.3 NF2 CRLF1
34 cerebellopontine angle tumor 10.3 NF2 CRLF1
35 benign paroxysmal positional nystagmus 10.3
36 neuritis 10.3
37 perilymphatic fistula 10.3
38 spinal cord ependymoma 10.3 NF2 LUC7L2
39 spinal cord glioma 10.3 NF2 LUC7L2
40 chronic purulent otitis media 10.3
41 pneumococcal meningitis 10.3
42 mumps 10.2
43 iritis 10.2 TNFRSF1B SRP72
44 amegakaryocytic thrombocytopenia, congenital 10.2 SRP72 LUC7L2
45 neurilemmoma 10.2
46 spinal cancer 10.2 NF2 LUC7L2
47 deafness, autosomal recessive 3 10.2 MYO7A GJB2
48 dfnb1 10.2 MYO7A GJB2
49 myxopapillary ependymoma 10.2 NF2 LUC7L2
50 vestibulocochlear nerve disease 10.2 FAM107B CRLF1

Comorbidity relations with Labyrinthitis via Phenotypic Disease Network (PDN): (show all 20)


Anxiety Basilar Artery Insufficiency
Benign Essential Hypertension Bronchitis
Cerebrovascular Disease Esophagitis
Generalized Atherosclerosis Hypertension, Essential
Hypothyroidism Inner Ear Disease
Intermediate Coronary Syndrome Meniere Disease
Otitis Media Pathologic Nystagmus
Peripheral Vertigo Transient Cerebral Ischemia
Vertebral Artery Insufficiency Vertigo, Benign Recurrent
Vestibular Nystagmus Viral Labyrinthitis

Graphical network of the top 20 diseases related to Labyrinthitis:



Diseases related to Labyrinthitis
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Symptoms & Phenotypes for Labyrinthitis

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UMLS symptoms related to Labyrinthitis:


vertigo, earache

MGI Mouse Phenotypes related to Labyrinthitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.17 ATOH1 FAM107B GJB2 MYO7A NF2 SALL1
Sources

Drugs & Therapeutics for Labyrinthitis

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Drugs for Labyrinthitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 2
2 Interleukin 1 Receptor Antagonist Protein Phase 2
3 Antirheumatic Agents Phase 2
4
Zinc Approved, Investigational 7440-66-6 32051
5 Gentamicins

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 An Open-label Study of the Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01950312 Phase 2 gevokizumab
2 A Phase I/II Open-label Study of the Effects of Anakinra in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01267994 Phase 1, Phase 2 Anakinra
3 A Phase II Placebo Controlled Study of the Effects of Anakinra (Kineret) in Subjects With Corticosteroid-Resistant Meniere's Disease (CR-MD) and Corticosteroid-Resistant Autoimmune Inner Ear Disease Disease (CR-AIED) Recruiting NCT03587701 Phase 2 Anakinra 100Mg/0.67Ml Inj Syringe (Period 1);Placebo injection (Period 1);Anakinra 100Mg/0.67Ml Inj Syringe (Period 2);Placebo injection (Period 2)
4 Safety and Efficacy of Intratympanically Delivered Golimumab for Stabilization of Hearing in Patients With Autoimmune Inner Ear Disease: An Open-label Proof-of-concept Clinical Trial Terminated NCT01526174 Phase 1, Phase 2 Golimumab
5 An Open-label, Single-dose, Pharmacokinetic Study of SENS-218 in Healthy Adult, Caucasian Subjects. Completed NCT02772796 Phase 1 SENS-218
6 A Randomised Double Blind, Multiple Dose, Pharmacokinetic and Safety Study of SENS 401 in Healthy Subjects Completed NCT03071003 Phase 1 SENS-401;Placebo
7 The Use of Virtual Reality for the Treatment of Visual Vertigo. Unknown status NCT03020654
8 Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) Alone or in Combination on Balance and Visual Function in Individuals With Vertigo and Somatic Dysfunction Completed NCT01529151
9 Unilateral Peripheral Vestibular Dysfunction: Reeducation and Spatial Orientation. Completed NCT03171181
10 Clinical Trial Evaluation of a Sensory Enrichment Multimodal Device (SEMD) on Physical Therapy Patients With Disequilibrium Completed NCT01483937
11 Single Session of Active Video Game Promotes Post Exercise Hypotension in Middle-aged Hypertensive Completed NCT02578485
12 Energy Demand in a Video Game Active Session and Potencial to Promove Post Exercise Hypotension in Hypertensive Women Completed NCT02924012
13 Maintaining Cochlear Patency After VIIIth Nerve Surgery Recruiting NCT03261726
14 First-in-Human Early Feasibility Study of Safety, Tolerability and Efficacy for a Multichannel Vestibular Implant in Individuals With Bilateral Severe-to-Profound Loss of Vestibular Sensation Recruiting NCT02725463
15 CNS Infections Effect on the Inner Ear Recruiting NCT03715569
16 Role of Multislice Computed Tomography and Magnetic Resonance Imaging in Preoperative Cochlear Implant Evaluation Recruiting NCT04131439
17 Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT) Not yet recruiting NCT04328181
18 Vestibular Function in Cochlear Implanted Hearing Impaired Children Not yet recruiting NCT03599804
19 Effects of Circuit Training on Vertigo, Oscillopsia and Dizziness in Patients With Vestibular Hypo-function Not yet recruiting NCT04261283

Search NIH Clinical Center for Labyrinthitis

Cochrane evidence based reviews: labyrinthitis

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Genetic Tests for Labyrinthitis

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Anatomical Context for Labyrinthitis

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MalaCards organs/tissues related to Labyrinthitis:

40
Bone, Eye, Testes, Brain, T Cells, Bone Marrow, Cortex
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Publications for Labyrinthitis

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Articles related to Labyrinthitis:

(show top 50) (show all 774)
# Title Authors PMID Year
1
Acute vestibular syndrome and hearing loss mimicking labyrinthitis as initial presentation of multiple sclerosis. 61
32353617 2020
2
Intraoperative Cochlear Implant Reinsertion Effects Evaluated by Electrode Impedance. 61
32569245 2020
3
Human Temporal Bone Study of Vestibular Histopathology in Cochlear Implant Patients With Cochlear Hydrops. 61
32150024 2020
4
Role of Free Radical Formation in Murine Cytomegalovirus-Induced Hearing Loss. 61
32041493 2020
5
HHV 6-7 reactivation causing Pityriasis Rosea and labyrinthitis: A case report. 61
32553563 2020
6
Cochlear implantation after traumatic brain injury without otic capsule fracture: A case report and literature review. 61
32471775 2020
7
Pediatric sudden sensorineural hearing loss: Experience in a pediatric ENT emergency care center. 61
32408010 2020
8
Dissociated Results between Caloric and Video Head Impulse Tests in Dizziness: Prevalence, Pattern, Lesion Location, and Etiology. 61
32319245 2020
9
Bilateral total deafness after preparation of wild boar meat. 61
32249147 2020
10
Histopathological changes to the peripheral vestibular system following meningitic labyrinthitis. 61
32337357 2020
11
Evolution of Cochlear implant mapping and vestibular function in a pediatric case of Labyrinthitis. 61
32024552 2020
12
Acute mastoiditis in children. 61
32073562 2020
13
Inner ear MRI: is it always useful to manage intravenous contrast? 61
32089257 2020
14
The impact of etiology and duration of deafness on speech perception outcomes in SSD patients. 61
31535291 2019
15
Dizziness demystified. 61
31326945 2019
16
Value of Routine Magnetic Resonance Imaging for the Preoperative Assessment of Cochlear Implant Candidates. 61
31911872 2019
17
Plinia cauliflora (Mart.) Kausel: A comprehensive ethnopharmacological review of a genuinely Brazilian species. 61
31425732 2019
18
The prognostic value and pathophysiologic significance of three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) magnetic resonance imaging in idiopathic sudden sensorineural hearing loss: A systematic review and meta-analysis. 61
31532907 2019
19
A case of external auditory canal osteoma complicated with cholesteatoma, mastoiditis, labyrinthitis and internal auditory canal pachymeningitis. 61
30745589 2019
20
Human Otopathology of Cochlear Implant Drill-out Procedures. 61
31060442 2019
21
Imaging of temporal bone inflammations in children: a pictorial review. 61
31321462 2019
22
Surveillance of antibiotic sensitivity pattern in chronic suppurative otitis media of an Indian teaching hospital. 61
31334487 2019
23
[Vertigo in children：composition and clinical characteristics]. 61
31163516 2019
24
Direction-Changing Positional Nystagmus in Acute Otitis Media Complicated by Serous Labyrinthitis: New Insights into Positional Nystagmus. 61
30870366 2019
25
Not 'just' a foreign body in the ear canal. 61
31036742 2019
26
"Emergency" Cochlear Implantation in Labyrinthitis Ossificans Secondary to Polyarteritis Nodosa: How to Face a Rare Entity. 61
30541729 2019
27
Etiology-Specific Mineralization Patterns in Patients with Labyrinthitis Ossificans. 61
30792250 2019
28
Cochlear implant in Thalassemia patient - Case report. 61
30232935 2019
29
Pathology in Practice. Opportunistic Pseudomonas aeruginosa infection as cause of otitis media and labyrinthitis in immunocompetent mice. 61
30605387 2019
30
Facial Nerve Stimulation Patterns Associated With Cochlear Implantation in Labyrinthitis Ossificans. 61
30444844 2018
31
Spontaneous Labyrinthine Hemorrhage: A Case Series. 61
29966483 2018
32
Postoperative MR imaging features after superior semicircular canal plugging in Minor syndrome. 61
30220585 2018
33
Cochlear implantation in children with meningitis related deafness: The influence of electrode impedance and implant charge on auditory performance - A case control study. 61
30173965 2018
34
Acute Otitis Media and Associated Complications in United States Emergency Departments. 61
30113560 2018
35
Differentiation Between Intralabyrinthine Schwannoma and Contrast-enhancing Labyrinthitis on MRI: Quantitative Analysis of Signal Intensity Characteristics. 61
30020263 2018
36
The first report of human meningitis and pyogenic ventriculitis caused by Streptococcus suis: A case report. 61
29429850 2018
37
Epidemiology of Vestibular Impairments in a Pediatric Population. 61
30038452 2018
38
[Otitis media: definition, pathogenesis, clinical presentation, diagnosis and therapy]. 61
29986368 2018
39
[Classification of acute vestibular syndrome]. 61
29921051 2018
40
Labyrinthitis Ossificans in a Cynomolgus Macaque (Macaca fascicularis). 61
29650059 2018
41
Labyrinthine Sequestrum: A Case Report and Review of the Literature. 61
29337715 2018
42
Gradenigo's Syndrome and Labyrinthitis: Conservative versus Surgical Treatment. 61
30155332 2018
43
Feasibility of magnetic resonance imaging in the differential diagnosis of isolated acute audiovestibular loss. 61
30856134 2018
44
Social representation of elderly people on falls: structural analysis and in the light of Neuman. 61
29791623 2018
45
Cochlear Implant Associated Labyrinthitis: A Previously Unrecognized Phenomenon With a Distinct Clinical and Electrophysiological Impedance Pattern. 61
29065095 2017
46
Characteristic MR findings suggesting presumed labyrinthine hemorrhage. 61
28826288 2017
47
[How to manage vertigo in adult?] 61
29089218 2017
48
The Differential Diagnosis of Vertigo in Children: A Systematic Review of 2726 Cases. 61
29095392 2017
49
Natural killer cells attenuate cytomegalovirus-induced hearing loss in mice. 61
28859161 2017
50
Pediatric Langerhans cell histiocytosis of the lateral skull base. 61
28688556 2017
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Variations for Labyrinthitis

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Expression for Labyrinthitis

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Search GEO for disease gene expression data for Labyrinthitis.
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Pathways for Labyrinthitis

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GO Terms for Labyrinthitis

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Biological processes related to Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sensory perception of sound GO:0007605 9.33 SLC26A4 MYO7A GJB2
2 ureteric bud development GO:0001657 9.26 SALL1 CRLF1
3 inner ear auditory receptor cell differentiation GO:0042491 8.96 MYO7A ATOH1
4 inner ear development GO:0048839 8.8 MYO7A GJB2 ATOH1
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Sources for Labyrinthitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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