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MCID: LBY004
MIFTS: 43

Labyrinthitis

Categories: Ear diseases, Infectious diseases, Neuronal diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Labyrinthitis

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MalaCards integrated aliases for Labyrinthitis:

Name: Labyrinthitis 12 74 44 15 17 71 32
Labyrinthine Disorder 71

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Ear diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1468
ICD9CM 34 386.3
MeSH 44 D007762
SNOMED-CT 67 155239008
ICD10 32 H83.0
UMLS 71 C0022890 C0022893
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Summaries for Labyrinthitis

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Disease Ontology : 12 An otitis interna which involves inflammation of the labyrinths.

MalaCards based summary : Labyrinthitis, also known as labyrinthine disorder, is related to purulent labyrinthitis and serous labyrinthitis, and has symptoms including vertigo and earache. An important gene associated with Labyrinthitis is LUC7L2 (LUC7 Like 2, Pre-MRNA Splicing Factor). The drugs Pharmaceutical Solutions and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and bone, and related phenotype is hearing/vestibular/ear.

Wikipedia : 74 Labyrinthitis, also known as vestibular neuritis, is the inflammation of the inner ear. Vestibular... more...

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Related Diseases for Labyrinthitis

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Diseases in the Labyrinthitis family:

Viral Labyrinthitis

Diseases related to Labyrinthitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 purulent labyrinthitis 32.2 NF2 GJB6 GJB2
2 serous labyrinthitis 31.9 SLC26A4 NF2 GJB2 ATOH1
3 viral labyrinthitis 31.8 GYPC GJB6 GJB2 ATOH1
4 branchiootic syndrome 1 30.9 SLC26A4 MYO7A GJB2
5 congenital cytomegalovirus 30.3 GJB6 GJB2
6 otosclerosis 29.9 SLC26A4 NF2 GJB2 COCH
7 sensorineural hearing loss 29.8 SLC26A4 MYO7A GJB6 GJB2 COCH ATOH1
8 meniere disease 29.5 SLC26A4 MYO7A GJB2 COCH
9 inner ear disease 29.3 SLC26A4 MYO7A GJB6 GJB2 COCH ATOH1
10 vestibular disease 29.0 SLC26A4 MYO7A GJB6 GJB2 COCH
11 usher syndrome 28.9 SLC26A4 MYO7A GJB6 GJB2 COCH
12 focal labyrinthitis 11.4
13 toxic labyrinthitis 11.4
14 vestibular neuronitis 11.0
15 meningitis 10.5
16 otitis media 10.5
17 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.5
18 bacterial meningitis 10.3
19 deafness, autosomal recessive 3 10.3 MYO7A GJB2
20 cholesteatoma of middle ear 10.3
21 pediatric meningioma 10.3 NF2 LUC7L2
22 spinal cord ependymoma 10.2 NF2 LUC7L2
23 deafness, autosomal recessive 83 10.2 SLC26A4 MYO7A
24 deafness, autosomal recessive 77 10.2 SLC26A4 GJB2
25 suppurative otitis media 10.2
26 deafness, autosomal dominant 41 10.2 SLC26A4 GJB2
27 usher syndrome, type ic 10.2 MYO7A GJB2
28 spinal cord glioma 10.2 NF2 LUC7L2
29 deafness, autosomal dominant 15 10.2 MYO7A ATOH1
30 eustachian tube disease 10.2 NR3C2 ATOH1
31 patulous eustachian tube 10.2 NR3C2 ATOH1
32 deafness, autosomal dominant 11 10.2 MYO7A GJB2
33 spinal cancer 10.2 NF2 LUC7L2
34 myxopapillary ependymoma 10.2 NF2 LUC7L2
35 deafness, autosomal dominant 1, with or without thrombocytopenia 10.2 MYO7A GJB2
36 mastoiditis 10.2
37 mumps 10.2
38 deafness, autosomal recessive 16 10.2 SLC26A4 GJB2
39 chronic purulent otitis media 10.2
40 pathologic nystagmus 10.2
41 pneumococcal meningitis 10.2
42 cogan syndrome 10.2 GJB2 COCH
43 ear malformation 10.2 SLC26A4 GJB2 ATOH1
44 deafness, autosomal dominant 2b 10.2 GJB2 COCH
45 autosomal recessive nonsyndromic deafness 10.2 SLC26A4 MYO7A GJB2
46 autosomal recessive nonsyndromic deafness 3 10.1 SLC26A4 MYO7A GJB2
47 amegakaryocytic thrombocytopenia, congenital 10.1 SRP72 LUC7L2
48 deafness, autosomal recessive 7 10.1 SLC26A4 MYO7A GJB2
49 deafness, autosomal dominant 6 10.1 SLC26A4 MYO7A GJB2
50 deafness, autosomal recessive 91 10.1 GJB2 COCH

Comorbidity relations with Labyrinthitis via Phenotypic Disease Network (PDN): (show all 20)


Anxiety Basilar Artery Insufficiency
Benign Essential Hypertension Bronchitis
Cerebrovascular Disease Esophagitis
Generalized Atherosclerosis Hypertension, Essential
Hypothyroidism Inner Ear Disease
Intermediate Coronary Syndrome Meniere Disease
Otitis Media Pathologic Nystagmus
Peripheral Vertigo Transient Cerebral Ischemia
Vertebral Artery Insufficiency Vertigo, Benign Recurrent
Vestibular Nystagmus Viral Labyrinthitis

Graphical network of the top 20 diseases related to Labyrinthitis:



Diseases related to Labyrinthitis
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Symptoms & Phenotypes for Labyrinthitis

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UMLS symptoms related to Labyrinthitis:


vertigo, earache

MGI Mouse Phenotypes related to Labyrinthitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.17 ATOH1 COCH GJB2 GJB6 MYO7A NF2
Sources

Drugs & Therapeutics for Labyrinthitis

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Drugs for Labyrinthitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 2
2 Antirheumatic Agents Phase 2
3 Interleukin 1 Receptor Antagonist Protein Phase 2
4
Calcium carbonate Approved, Investigational 471-34-1
5
Zinc Approved, Investigational 7440-66-6 32051
6 Gentamicins

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Efficiency of Motor Training Program Associated With Extrenal Cues on the Balance of Patients With Parkinson's Disease. Completed NCT01960985 Phase 3
2 A Phase I/II Open-label Study of the Effects of Anakinra in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01267994 Phase 1, Phase 2 Anakinra
3 An Open-label Study of the Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01950312 Phase 2 gevokizumab
4 A Phase II Placebo Controlled Study of the Effects of Anakinra (Kineret) in Subjects With Corticosteroid-Resistant Meniere's Disease (CR-MD) and Corticosteroid-Resistant Autoimmune Inner Ear Disease Disease (CR-AIED) Recruiting NCT03587701 Phase 2 Anakinra 100Mg/0.67Ml Inj Syringe (Period 1);Placebo injection (Period 1);Anakinra 100Mg/0.67Ml Inj Syringe (Period 2);Placebo injection (Period 2)
5 Safety and Efficacy of Intratympanically Delivered Golimumab for Stabilization of Hearing in Patients With Autoimmune Inner Ear Disease: An Open-label Proof-of-concept Clinical Trial Terminated NCT01526174 Phase 1, Phase 2 Golimumab
6 An Open-label, Single-dose, Pharmacokinetic Study of SENS-218 in Healthy Adult, Caucasian Subjects. Completed NCT02772796 Phase 1 SENS-218
7 A Randomised Double Blind, Multiple Dose, Pharmacokinetic and Safety Study of SENS 401 in Healthy Subjects Completed NCT03071003 Phase 1 SENS-401;Placebo
8 Cognitive Sequels of Cushing Syndrome Unknown status NCT02603653
9 3D Finite Element Model of Posterior Membranous Labyrinth From in Vivo MRI of Human Temporal Bone Unknown status NCT03295929
10 Transcranial Direct Current Stimulation and Computer-based Training for the Rehabilitation of Cognitive Function in Traumatic Brain Injury: a Randomized Controlled Trial Unknown status NCT03382626
11 CNS Infections Effect on the Inner Ear Unknown status NCT03715569
12 Early Postoperative Imaging of the Labyrinth by Cone Beam CT After Stapes Surgery for Otosclerosis With Correlation to Audiovestibular Outcome Completed NCT02901093
13 The Effect of Ankle Taping and Balance Exercises on Postural Stability Indices in Healthy Women Completed NCT01730859
14 A Randomized Controlled Single-Blind Crossover Trial on the Effects of Serious Games and Wearable Haptic Devices in the Rehabilitation of Children With Neuromotor Impairments Completed NCT03353623
15 Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) Alone or in Combination on Balance and Visual Function in Individuals With Vertigo and Somatic Dysfunction Completed NCT01529151
16 Clinical Trial Evaluation of a Sensory Enrichment Multimodal Device (SEMD) on Physical Therapy Patients With Disequilibrium Completed NCT01483937
17 Unilateral Peripheral Vestibular Dysfunction: Reeducation and Spatial Orientation. Completed NCT03171181
18 Non Enhanced Labyrinth Imaging for the Detection of Endolymphatic Hydrops in Meniere's Disease "NELI Study" Recruiting NCT04569175
19 Study of Navigation Skills in Cerebral Palsy for Assessment and Rehabilitation in Immersive Virtual Reality Recruiting NCT04270305
20 Imaging SARS-CoV-2 Involvement of Leptomeninges, Olfactory and Limbic Areas Recruiting NCT04448054
21 First-in-Human Early Feasibility Study of Safety, Tolerability and Efficacy for a Multichannel Vestibular Implant in Individuals With Bilateral Severe-to-Profound Loss of Vestibular Sensation Recruiting NCT02725463
22 Maintaining Cochlear Patency After VIIIth Nerve Surgery Recruiting NCT03261726
23 Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT) Not yet recruiting NCT04328181

Search NIH Clinical Center for Labyrinthitis

Cochrane evidence based reviews: labyrinthitis

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Genetic Tests for Labyrinthitis

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Anatomical Context for Labyrinthitis

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MalaCards organs/tissues related to Labyrinthitis:

40
Eye, Brain, Bone, Bone Marrow, Cortex, Breast, Endothelial
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Publications for Labyrinthitis

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Articles related to Labyrinthitis:

(show top 50) (show all 793)
# Title Authors PMID Year
1
CT Scan Showing Ossicular Chain Arthritis Associated With Ossifying Labyrinthitis as Rare Signs of Relapsing Polychondritis. 61
33606473 2021
2
Otopathologic Analysis of Patterns of Postmeningitis Labyrinthitis Ossificans. 61
32600100 2021
3
Enhanced Otolith Function Despite Severe Labyrinthine Damage in a Case of Pneumolabyrinth and Pneumocephalus Due to Otogenic Meningitis Associated With Superior Canal Dehiscence. 61
33026781 2021
4
Intraoperative auditory brainstem response monitoring during semicircular canal plugging surgery in treatment of Meniere's disease. 61
33074754 2021
5
Intracranial long-term complications of radiation therapy: an image-based review. 61
33392738 2021
6
Efficacy and Comparison of Vestibular Rehabilitation Exercises on Quality of Life in Patients with Vestibular Disorders. 61
33088777 2020
7
Labyrinthitis Ossificans and Cholesteatoma Associated With Gardner Syndrome: A Rare Case. 61
32600114 2020
8
The Treatment of Cholesteatomas Involving the Antrum and Mastoid Using Transcanal Underwater Endoscopic Ear Surgery. 61
32947491 2020
9
Aetiology of Ludwig van Beethoven's hearing impairment: hypotheses over the past 100 years - A systematic review. 61
33230590 2020
10
Bilateral total deafness after preparation of wild boar meat. 61
32249147 2020
11
Standard Programming of Retrograde Electrode Insertion via Middle-Turn Cochleostomy in Labyrinthitis Ossificans. 61
33226852 2020
12
Anatomical and Pathological Findings of Magnetic Resonance Imaging in Idiopathic Sudden Sensorineural Hearing Loss. 61
32927937 2020
13
HHV 6-7 reactivation causing Pityriasis Rosea and labyrinthitis: A case report. 61
32553563 2020
14
Inner ear MRI: is it always useful to manage intravenous contrast? 61
32089257 2020
15
The Differential Diagnosis of Vertigo in Children: A Systematic Review of 2726 Cases. 61
29095392 2020
16
Pediatric sudden sensorineural hearing loss: Experience in a pediatric ENT emergency care center. 61
32408010 2020
17
Acute vestibular syndrome and hearing loss mimicking labyrinthitis as initial presentation of multiple sclerosis. 61
32353617 2020
18
[Clinical analysis of complications of suppurative otitis media in children]. 61
32791630 2020
19
Cochlear implantation after traumatic brain injury without otic capsule fracture: A case report and literature review. 61
32471775 2020
20
Intraoperative Cochlear Implant Reinsertion Effects Evaluated by Electrode Impedance. 61
32569245 2020
21
Human Temporal Bone Study of Vestibular Histopathology in Cochlear Implant Patients With Cochlear Hydrops. 61
32150024 2020
22
Incidence of Inner Ear Disorders in Various Forms of Acute Otitis Media in ENT Practices in Germany. 61
32579395 2020
23
Role of Free Radical Formation in Murine Cytomegalovirus-Induced Hearing Loss. 61
32041493 2020
24
Labyrinthitis and Labyrinthitis Ossificans - A case report and review of the literature. 61
33082921 2020
25
Histopathological changes to the peripheral vestibular system following meningitic labyrinthitis. 61
32337357 2020
26
Dissociated Results between Caloric and Video Head Impulse Tests in Dizziness: Prevalence, Pattern, Lesion Location, and Etiology. 61
32319245 2020
27
Acute mastoiditis in children. 61
32073562 2020
28
Evolution of Cochlear implant mapping and vestibular function in a pediatric case of Labyrinthitis. 61
32024552 2020
29
Plinia cauliflora (Mart.) Kausel: A comprehensive ethnopharmacological review of a genuinely Brazilian species. 61
31425732 2019
30
The impact of etiology and duration of deafness on speech perception outcomes in SSD patients. 61
31535291 2019
31
Dizziness demystified. 61
31326945 2019
32
Value of Routine Magnetic Resonance Imaging for the Preoperative Assessment of Cochlear Implant Candidates. 61
31911872 2019
33
The prognostic value and pathophysiologic significance of three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) magnetic resonance imaging in idiopathic sudden sensorineural hearing loss: A systematic review and meta-analysis. 61
31532907 2019
34
A case of external auditory canal osteoma complicated with cholesteatoma, mastoiditis, labyrinthitis and internal auditory canal pachymeningitis. 61
30745589 2019
35
Human Otopathology of Cochlear Implant Drill-out Procedures. 61
31060442 2019
36
Imaging of temporal bone inflammations in children: a pictorial review. 61
31321462 2019
37
Surveillance of antibiotic sensitivity pattern in chronic suppurative otitis media of an Indian teaching hospital. 61
31334487 2019
38
[Vertigo in children：composition and clinical characteristics]. 61
31163516 2019
39
Direction-Changing Positional Nystagmus in Acute Otitis Media Complicated by Serous Labyrinthitis: New Insights into Positional Nystagmus. 61
30870366 2019
40
"Emergency" Cochlear Implantation in Labyrinthitis Ossificans Secondary to Polyarteritis Nodosa: How to Face a Rare Entity. 61
30541729 2019
41
Not 'just' a foreign body in the ear canal. 61
31036742 2019
42
Etiology-Specific Mineralization Patterns in Patients with Labyrinthitis Ossificans. 61
30792250 2019
43
Cochlear implant in Thalassemia patient - Case report. 61
30232935 2019
44
Pathology in Practice. Opportunistic Pseudomonas aeruginosa infection as cause of otitis media and labyrinthitis in immunocompetent mice. 61
30605387 2019
45
Facial Nerve Stimulation Patterns Associated With Cochlear Implantation in Labyrinthitis Ossificans. 61
30444844 2018
46
Spontaneous Labyrinthine Hemorrhage: A Case Series. 61
29966483 2018
47
Postoperative MR imaging features after superior semicircular canal plugging in Minor syndrome. 61
30220585 2018
48
Cochlear implantation in children with meningitis related deafness: The influence of electrode impedance and implant charge on auditory performance - A case control study. 61
30173965 2018
49
Acute Otitis Media and Associated Complications in United States Emergency Departments. 61
30113560 2018
50
Differentiation Between Intralabyrinthine Schwannoma and Contrast-enhancing Labyrinthitis on MRI: Quantitative Analysis of Signal Intensity Characteristics. 61
30020263 2018
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Variations for Labyrinthitis

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Expression for Labyrinthitis

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Search GEO for disease gene expression data for Labyrinthitis.
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Pathways for Labyrinthitis

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GO Terms for Labyrinthitis

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Cellular components related to Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 8.96 GJB6 GJB2
2 connexin complex GO:0005922 8.62 GJB6 GJB2

Biological processes related to Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction assembly GO:0016264 9.37 GJB6 GJB2
2 inner ear auditory receptor cell differentiation GO:0042491 9.32 MYO7A ATOH1
3 cell communication by electrical coupling GO:0010644 9.26 GJB6 GJB2
4 inner ear development GO:0048839 9.26 MYO7A GJB6 GJB2 ATOH1
5 gap junction-mediated intercellular transport GO:1990349 9.16 GJB6 GJB2
6 sensory perception of sound GO:0007605 9.02 SLC26A4 MYO7A GJB6 GJB2 COCH

Molecular functions related to Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction channel activity GO:0005243 8.96 GJB6 GJB2
2 gap junction channel activity involved in cell communication by electrical coupling GO:1903763 8.62 GJB6 GJB2
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Sources for Labyrinthitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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