MCID: LBY004
MIFTS: 46

Labyrinthitis

Categories: Ear diseases, Infectious diseases, Neuronal diseases
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Aliases & Classifications for Labyrinthitis

MalaCards integrated aliases for Labyrinthitis:

Name: Labyrinthitis 11 75 43 14 16 71 31 33
Inner Ear Inflammation 33
Labyrinthine Disorder 71
Labyrinth Hyperaemia 33
Otitis Interna 33

Classifications:



External Ids:

Disease Ontology 11 DOID:1468
ICD9CM 34 386.3
MeSH 43 D007762
SNOMED-CT 68 155239008
ICD10 31 H83.0
ICD11 33 901550793
UMLS 71 C0022890 C0022893

Summaries for Labyrinthitis

Disease Ontology: 11 An otitis interna which involves inflammation of the labyrinths.

MalaCards based summary: Labyrinthitis, also known as inner ear inflammation, is related to purulent labyrinthitis and vestibular neuronitis, and has symptoms including vertigo and earache. An important gene associated with Labyrinthitis is LUC7L2 (LUC7 Like 2, Pre-MRNA Splicing Factor), and among its related pathways/superpathways are Overview of nanoparticle effects and Cellular roles of Anthrax toxin. The drugs Golimumab and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and bone, and related phenotype is hearing/vestibular/ear.

Wikipedia: 75 Labyrinthitis is inflammation of the labyrinth - a maze of fluid-filled channels in the inner ear.... more...

Related Diseases for Labyrinthitis

Diseases in the Labyrinthitis family:

Viral Labyrinthitis

Diseases related to Labyrinthitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 476)
# Related Disease Score Top Affiliating Genes
1 purulent labyrinthitis 32.5 NF2 GJB6 GJB2
2 vestibular neuronitis 31.8 POLR1C CRP
3 viral labyrinthitis 31.7 GYPC GJB6 GJB2 ATOH1
4 congenital cytomegalovirus 30.6 GJB6 GJB2
5 meningitis 30.5 TNF IL1B CRP
6 otitis media 30.4 TNF IL1B CRP
7 bacterial meningitis 30.2 TNF IL1B CRP
8 haemophilus influenzae 30.2 TNF IL1B
9 bell's palsy 30.1 TNF CRP
10 meniere disease 30.1 SLC26A4 POLR1C MYO7A GJB2 COCH
11 facial paralysis 29.9 TNF NF2 CRP
12 vestibular disease 29.9 SLC26A4 MYO7A GJB6 GJB2 COCH
13 inner ear disease 29.9 SLC26A4 MYO7A GJB6 GJB2 COCH ATOH1
14 sensorineural hearing loss 29.8 SLC26A4 POLR1C NF2 MYO7A GJB6 GJB2
15 septic arthritis 29.7 TNF IL1B CRP
16 neurosarcoidosis 29.6 TNF CRP
17 exanthem 29.6 TNF IL1B CRP
18 bone inflammation disease 29.6 TNF IL1B CRP
19 usher syndrome 29.4 SLC26A4 MYO7A GJB6 GJB2 ATOH1
20 cranial nerve palsy 29.4 TNF NF2 CRP
21 relapsing polychondritis 29.4 TNF CRP
22 meningoencephalitis 29.4 TNF IL1B CRP
23 spondyloarthropathy 1 29.4 TNF IL1B CRP
24 severe acute respiratory syndrome 29.3 TNF IL1B CRP
25 crohn's disease 29.3 TNF IL1B CRP
26 otosclerosis 29.2 SLC26A4 POLR1C NF2 MYO7A GJB6 GJB2
27 middle ear disease 29.2 TNF IL1B GJB2 CRP
28 chickenpox 28.8 TNF IL1B GYPC CRP
29 nervous system disease 28.3 TNF SLC26A4 NF2 MYO7A LUC7L2 IL1B
30 focal labyrinthitis 11.4
31 toxic labyrinthitis 11.4
32 serous labyrinthitis 11.3
33 bone marrow failure syndrome 1 10.9
34 deafness, autosomal recessive 3 10.3 MYO7A GJB2
35 deafness, autosomal recessive 76 10.3 MYO7A GJB2
36 cochlear disease 10.3 SLC26A4 GJB2
37 deafness and myopia 10.3 MYO7A GJB2
38 y-linked deafness 10.3 SLC26A4 GJB2
39 cholesteatoma of middle ear 10.3
40 nonsyndromic hearing loss and deafness, dfnb1 10.3 GJB6 GJB2
41 deafness, autosomal dominant 59 10.3 GJB6 GJB2
42 deafness, autosomal recessive 8 10.3 SLC26A4 GJB2
43 deafness, autosomal recessive 91 10.3 GJB2 COCH
44 deafness, autosomal dominant 3a 10.3 GJB2 COCH
45 deafness, autosomal recessive 83 10.3 SLC26A4 MYO7A
46 suppurative otitis media 10.3
47 deafness, autosomal dominant 3b 10.3 GJB6 GJB2
48 deafness, autosomal recessive 39 10.3 MYO7A GJB2
49 childhood meningioma 10.3 NF2 LUC7L2
50 deafness, autosomal dominant 12 10.3 GJB6 GJB2

Comorbidity relations with Labyrinthitis via Phenotypic Disease Network (PDN): (show all 20)


Anxiety Basilar Artery Insufficiency
Benign Essential Hypertension Bronchitis
Cerebrovascular Disease Esophagitis
Generalized Atherosclerosis Hypertension, Essential
Hypothyroidism Inner Ear Disease
Intermediate Coronary Syndrome Meniere Disease
Otitis Media Pathologic Nystagmus
Peripheral Vertigo Transient Cerebral Ischemia
Vertebral Artery Insufficiency Vertigo, Benign Recurrent
Vestibular Nystagmus Viral Labyrinthitis

Graphical network of the top 20 diseases related to Labyrinthitis:



Diseases related to Labyrinthitis

Symptoms & Phenotypes for Labyrinthitis

UMLS symptoms related to Labyrinthitis:


vertigo; earache

MGI Mouse Phenotypes related to Labyrinthitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.17 ATOH1 COCH GJB2 GJB6 MYO7A NF2

Drugs & Therapeutics for Labyrinthitis

Drugs for Labyrinthitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Golimumab Approved Phase 1, Phase 2 476181-74-5
2 Pharmaceutical Solutions Phase 2
3 Antirheumatic Agents Phase 2
4 Interleukin 1 Receptor Antagonist Protein Phase 2
5 Tumor Necrosis Factor Inhibitors Phase 1, Phase 2
6 Anti-Inflammatory Agents Phase 1, Phase 2
7 Immunosuppressive Agents Phase 1, Phase 2
8 Immunologic Factors Phase 1, Phase 2
9
Zinc cation Approved, Experimental, Investigational 7440-66-6, 23713-49-7 32051
10 Gentamicins

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 An Open-label Study of the Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01950312 Phase 2 gevokizumab
2 A Phase I/II Open-label Study of the Effects of Anakinra in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01267994 Phase 1, Phase 2 Anakinra
3 A Phase II Placebo Controlled Study of the Effects of Anakinra (Kineret) in Subjects With Corticosteroid-Resistant/Intolerant Meniere's Disease (CR-MD) and Corticosteroid-Resistant/Intolerant Autoimmune Inner Ear Disease Disease (CR-AIED) Recruiting NCT03587701 Phase 2 Anakinra 100Mg/0.67Ml Inj Syringe (Period 1);Placebo injection (Period 1);Anakinra 100Mg/0.67Ml Inj Syringe (Period 2);Placebo injection (Period 2)
4 Safety and Efficacy of Intratympanically Delivered Golimumab for Stabilization of Hearing in Patients With Autoimmune Inner Ear Disease: An Open-label Proof-of-concept Clinical Trial Terminated NCT01526174 Phase 1, Phase 2 Golimumab
5 An Open-label, Single-dose, Pharmacokinetic Study of SENS-218 in Healthy Adult, Caucasian Subjects. Completed NCT02772796 Phase 1 SENS-218
6 A Randomised Double Blind, Multiple Dose, Pharmacokinetic and Safety Study of SENS 401 in Healthy Subjects Completed NCT03071003 Phase 1 SENS-401;Placebo
7 CNS Infections Effect on the Inner Ear Unknown status NCT03715569
8 Quantification of the Effect of the OtoBand, a Non-invasive Vestibular Masker, on Objective Measures of Vertigo and Dizziness Completed NCT05157399
9 Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) Alone or in Combination on Balance and Visual Function in Individuals With Vertigo and Somatic Dysfunction Completed NCT01529151
10 Unilateral Peripheral Vestibular Dysfunction: Reeducation and Spatial Orientation. Completed NCT03171181
11 Clinical Trial Evaluation of a Sensory Enrichment Multimodal Device (SEMD) on Physical Therapy Patients With Disequilibrium Completed NCT01483937
12 Single-sided Deafness and Cochlear Implantation Recruiting NCT05052944
13 Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT) Recruiting NCT04328181
14 First-in-Human Early Feasibility Study of Safety, Tolerability and Efficacy for a Multichannel Vestibular Implant in Individuals With Bilateral Severe-to-Profound Loss of Vestibular Sensation Recruiting NCT02725463
15 Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets Recruiting NCT04806282
16 Vestibular Precision: Physiology & Pathophysiology Enrolling by invitation NCT04890132
17 Randomized Controlled Trial of Computerized Dynamic Posturography-assisted Vestibular Retraining Compared With At-home Vestibular Rehabilitation Exercises for Stable Unilateral Vestibular Deficit Enrolling by invitation NCT05115032
18 Effect of Peripheral Vestibular Pathology Location on the Ability of Home-based Virtual Reality to Improve Symptoms of Peripheral Vestibular Disorders Not yet recruiting NCT05424302
19 Maintaining Cochlear Patency After VIIIth Nerve Surgery Withdrawn NCT03261726

Search NIH Clinical Center for Labyrinthitis

Cochrane evidence based reviews: labyrinthitis

Genetic Tests for Labyrinthitis

Anatomical Context for Labyrinthitis

Organs/tissues related to Labyrinthitis:

MalaCards : Eye, Brain, Bone, Bone Marrow, T Cells, Cortex, Endothelial

Publications for Labyrinthitis

Articles related to Labyrinthitis:

(show top 50) (show all 870)
# Title Authors PMID Year
1
Robotic cochlear implantation in post-meningitis ossified cochlea. 62
36323158 2023
2
Standard Programming of Retrograde Electrode Insertion via Middle-Turn Cochleostomy in Labyrinthitis Ossificans. 62
33226852 2022
3
Managing the Destructive Foreign Body: Water Beads in the Ear (A Case Series) and Literature Review. 62
36341897 2022
4
Recent Advancements in Understanding the Gut Microbiome and the Inner Ear Axis. 62
36088154 2022
5
Diagnostic value and prognostic significance of MRI findings in sudden sensorineural hearing loss. 62
36258869 2022
6
Histopathology of Labyrinthitis Ossificans From an Intralabyrinthine Surgical Specimen. 62
35970153 2022
7
Differences in vestibulo-ocular reflex time constants in patients with vestibular migraine versus vestibular neuritis/labyrinthitis. 62
35963107 2022
8
Intratympanic injection of dexamethasone for management of labyrinthitis associated with COVID-19 disease resistant cases. 62
35989722 2022
9
Inner ear modifications in Dar-es-Soltane II H5 (Morocco): A case of labyrinthitis ossificans. 62
35809435 2022
10
The great imitator: latent neurosyphilis presenting with uveitis and labyrinthitis. 62
36057737 2022
11
Management of otogene extracranial complications in children and adolescents: report of 35 cases over 10 years. 62
36102988 2022
12
Correlation of Preoperative High-resolution Computed Tomography Temporal Bone Findings with Intra-operative Findings in Various Ear Pathologies. 62
36032829 2022
13
Simultaneous Late, Late-Onset Group B Streptococcal Meningitis in Identical Twins. 62
35883267 2022
14
A 14-year nationwide epidemiological analysis of delayed endolymphatic hydrops in Japan. 62
35984435 2022
15
Acute vestibular neuritis: A rare complication after the adenoviral vector-based COVID-19 vaccine. 62
35877063 2022
16
Rapid progressive destruction of the cochleae in an infant due to pneumococcal meningitis. 62
35078720 2022
17
Magnetic Resonance Imaging in Otosyphilis: A Rare Manifestation of Neurosyphilis. 62
35924136 2022
18
A High-Fat Diet Induces Low-Grade Cochlear Inflammation in CD-1 Mice. 62
35563572 2022
19
Pediatric tinnitus: The role of neuroimaging. 62
35307901 2022
20
Labyrinthitis ossificans following severe acute otitis media. 62
35646348 2022
21
Cochlear implantation after deafness from Pasteurella multocida meningitis. 62
35428666 2022
22
Neurogenic keratoconjunctivitis sicca in 34 dogs: A case series. 62
34870366 2022
23
Labyrinthitis With Endolymphatic Hydrops Revealed by Imaging Analysis in a Case With Severe Postoperative Complications Following Stapes Surgery. 62
34411064 2022
24
Signal Alteration of the Inner Ear on High-Resolution Three-Dimensional Constructive Interference in Steady State Sequence in Patients with Ménière's Disease and Labyrinthitis. 62
36037798 2022
25
The Spectrum of Vestibular Disorders Presenting With Acute Continuous Vertigo. 62
35911992 2022
26
Case Report: Suppurative Labyrinthitis Induced by Chronic Suppurative Otitis Media. 62
35756914 2022
27
Three-Dimensional High-Resolution Temporal Bone Histopathology Identifies Areas of Vascular Vulnerability in the Inner Ear. 62
34965531 2022
28
[Surgical management of 27 cases with temporal bone cerebrospinal fluid leakage]. 62
34886603 2021
29
Long-Term Outcome of Cochlear Implantation in Post-meningitic Deafnes. 62
35177386 2021
30
Enterococcus spp. Meningoencephalitis, Ventriculitis, and Hypophysitis in a Dog. 62
34606588 2021
31
Cochlin Deficiency Protects Aged Mice from Noise-Induced Hearing Loss. 62
34768980 2021
32
Clinical usefulness of labyrinthine three-dimensional fluid-attenuated inversion recovery magnetic resonance images in idiopathic sudden sensorineural hearing loss. 62
34459797 2021
33
Transient third-degree atrioventricular block during anesthesia in a cat. 62
35070861 2021
34
Cannabinoid Receptor 2 Agonism is Capable of Preventing Lipopolysaccharide Induced Decreases of Cochlear Microcirculation - A Potential Approach for Inner Ear Pathologies. 62
34267099 2021
35
Labyrinthitis: A Rare Consequence of COVID-19 Infection. 62
34548960 2021
36
Primary presentation of sarcoidosis with profound bilateral sensorineural hearing loss. 62
34433534 2021
37
Aetiology of Ludwig van Beethoven's hearing impairment: hypotheses over the past 100 years - A systematic review. 62
33230590 2021
38
CT Scan Showing Ossicular Chain Arthritis Associated With Ossifying Labyrinthitis as Rare Signs of Relapsing Polychondritis. 62
33606473 2021
39
Incidence of Inner Ear Disorders in Various Forms of Acute Otitis Media in ENT Practices in Germany. 62
32579395 2021
40
Intracranial long-term complications of radiation therapy: an image-based review. 62
33392738 2021
41
Acute Labyrinthitis Revealing COVID-19. 62
33803267 2021
42
Case Report: Could Hennebert's Sign Be Evoked Despite Global Vestibular Impairment on Video Head Impulse Test? Considerations Upon Pathomechanisms Underlying Pressure-Induced Nystagmus due to Labyrinthine Fistula. 62
33854475 2021
43
Intraoperative auditory brainstem response monitoring during semicircular canal plugging surgery in treatment of Meniere's disease. 62
33074754 2021
44
Enhanced Otolith Function Despite Severe Labyrinthine Damage in a Case of Pneumolabyrinth and Pneumocephalus Due to Otogenic Meningitis Associated With Superior Canal Dehiscence. 62
33026781 2021
45
Otopathologic Analysis of Patterns of Postmeningitis Labyrinthitis Ossificans. 62
32600100 2021
46
The Treatment of Cholesteatomas Involving the Antrum and Mastoid Using Transcanal Underwater Endoscopic Ear Surgery. 62
32947491 2020
47
Efficacy and Comparison of Vestibular Rehabilitation Exercises on Quality of Life in Patients with Vestibular Disorders. 62
33088777 2020
48
Labyrinthitis Ossificans and Cholesteatoma Associated With Gardner Syndrome: A Rare Case. 62
32600114 2020
49
Bilateral total deafness after preparation of wild boar meat. 62
32249147 2020
50
Anatomical and Pathological Findings of Magnetic Resonance Imaging in Idiopathic Sudden Sensorineural Hearing Loss. 62
32927937 2020

Variations for Labyrinthitis

Expression for Labyrinthitis

Search GEO for disease gene expression data for Labyrinthitis.

Pathways for Labyrinthitis

Pathways related to Labyrinthitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.43 TNF CRP
2 10.23 TNF IL1B
3 9.83 TNF IL1B

GO Terms for Labyrinthitis

Biological processes related to Labyrinthitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.91 GJB2 GJB6 IL1B TNF
2 positive regulation of neuroinflammatory response GO:0150078 9.84 TNF IL1B
3 regulation of establishment of endothelial barrier GO:1903140 9.83 TNF IL1B
4 negative regulation of lipid storage GO:0010888 9.81 TNF CRP
5 gap junction assembly GO:0016264 9.8 GJB6 GJB2
6 vascular endothelial growth factor production GO:0010573 9.78 TNF IL1B
7 cell communication by electrical coupling GO:0010644 9.76 GJB6 GJB2
8 gap junction-mediated intercellular transport GO:1990349 9.73 GJB6 GJB2
9 sensory perception of sound GO:0007605 9.65 SLC26A4 MYO7A GJB6 GJB2 COCH
10 positive regulation of fever generation GO:0031622 9.62 IL1B TNF
11 cell communication GO:0007154 9.58 TNF GJB6 GJB2
12 sequestering of triglyceride GO:0030730 9.56 TNF IL1B
13 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 TNF IL1B
14 inner ear development GO:0048839 9.1 MYO7A GJB6 GJB2 ATOH1

Molecular functions related to Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction channel activity involved in cell communication by electrical coupling GO:1903763 8.92 GJB6 GJB2

Sources for Labyrinthitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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