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MCID: LCR008
MIFTS: 41

Lacrimal Apparatus Disease

Categories: Eye diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lacrimal Apparatus Disease

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MalaCards integrated aliases for Lacrimal Apparatus Disease:

Name: Lacrimal Apparatus Disease 12 15 17
Lacrimal Apparatus Diseases 70

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Eye diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1400
ICD9CM 34 375
MeSH 44 D007766
NCIt 50 C26809
SNOMED-CT 67 267740009
ICD10 32 H04
UMLS 70 C0022904
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Summaries for Lacrimal Apparatus Disease

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Disease Ontology : 12 An eye disease that affects the lacrimal apparatus (the lacrimal gland and its related structures) which moisten and drain the eye.

MalaCards based summary : Lacrimal Apparatus Disease, also known as lacrimal apparatus diseases, is related to dry eye syndrome and chronic inflammation of lacrimal passage, and has symptoms including visual disturbance, eye manifestations and dacryops. An important gene associated with Lacrimal Apparatus Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and skin.

Wikipedia : 73 The lacrimal apparatus is the physiological system containing the orbital structures for tear production... more...

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Related Diseases for Lacrimal Apparatus Disease

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Diseases in the Lacrimal Apparatus Disease family:

Rare Disorder of the Lacrimal Apparatus

Diseases related to Lacrimal Apparatus Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 632)
# Related Disease Score Top Affiliating Genes
1 dry eye syndrome 31.3 TRIM21 TNF PRR4 P2RY2 MUC5AC MUC4
2 chronic inflammation of lacrimal passage 11.2
3 neurosyphilis 10.5 IL17A CXCL8
4 diffuse infiltrative lymphocytosis syndrome 10.5 TRIM21 SSB CD4
5 external pathological resorption 10.5 TNF IL6
6 parotid disease 10.5 TRIM21 SSB CD4
7 scorpion envenomation 10.4 TNF IL6
8 subacute cutaneous lupus erythematosus 10.4 TRIM21 TNF
9 esophageal candidiasis 10.4 IL17A CD4 CCR6
10 subcutaneous mycosis 10.4 IL17A CD4 CCR6
11 autoimmune cholangitis 10.4 IL17A CD4 CCR6
12 dermatophytosis 10.4 IL17A CD4 CCR6
13 coccidioidomycosis 10.4 IL17A CD4 CCR6
14 accommodative spasm 10.4 P2RY2 LACRT AQP5
15 staphylococcal toxic shock syndrome 10.4 TNF IL1B
16 legume allergy 10.4 ICOSLG CD4 CCR6
17 fruit allergy 10.4 ICOSLG CD4 CCR6
18 silo filler's disease 10.4 MUC5AC IL1B IL17A
19 immunodeficiency 16 10.4 ICOSLG CD4 CCR6
20 autoimmune inner ear disease 10.4 TNF MMP9
21 autoimmune glomerulonephritis 10.4 ICOSLG CD4 CCR6
22 cap polyposis 10.4 MUC5AC MUC4
23 chronic follicular conjunctivitis 10.4 PRR4 LCN1 LACRT
24 tuberculoid leprosy 10.4 TNF CD4 CCR6
25 primary thrombocytopenia 10.4 ICOSLG CD4 CCR6
26 prosthetic joint infection 10.4 IL6 IL1B
27 uveoparotid fever 10.4 TNF SSB CD4
28 retinal vasculitis 10.4 TNF CD4 CCR6
29 periodontitis, chronic 10.4 IL6 IL1B
30 immunoglobulin alpha deficiency 10.4 ICOSLG CD4 CCR6
31 arachnoiditis 10.4 TNF IL1B CD4
32 anemia, autoimmune hemolytic 10.4 ICOSLG CD4 CCR6
33 meningovascular neurosyphilis 10.4 TNF IL17A CD4
34 cerebritis 10.4 TNF IL1B CD4
35 paratyphoid fever 10.4 TNF IL1B CCR6
36 respiratory allergy 10.4 ICOSLG CD4 CCR6
37 herpes simplex virus keratitis 10.4 CXCL8 CD4 CCR6
38 histoplasmosis 10.4 TNF CD4 CCR6
39 physiological polycythemia 10.4 TNF IL6 IL1B
40 palladium allergic contact dermatitis 10.4 TNF IL1B IL17A
41 limited scleroderma 10.4 TRIM21 SSB CCR6
42 nasopharyngitis 10.4 TNF IL17A CCR6
43 bullous skin disease 10.4 ICOSLG CD4 CCR6
44 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 TNF IL6
45 farmer's lung 10.4 TNF IL17A CD4
46 immunodeficiency with hyper-igm, type 1 10.4 ICOSLG CD4 CCR6
47 rheumatoid arthritis interstitial lung disease 10.4 TNF CD4
48 pneumonic plague 10.4 TNF IL17A CD4
49 chemical colitis 10.4 TNF IL1B IL17A
50 superficial basal cell carcinoma 10.4 TNF IL6 CD4

Graphical network of the top 20 diseases related to Lacrimal Apparatus Disease:



Diseases related to Lacrimal Apparatus Disease
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Symptoms & Phenotypes for Lacrimal Apparatus Disease

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UMLS symptoms related to Lacrimal Apparatus Disease:


visual disturbance; eye manifestations; dacryops
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Drugs & Therapeutics for Lacrimal Apparatus Disease

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Drugs for Lacrimal Apparatus Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
7 Hormones Phase 4
8 glucocorticoids Phase 4
9 Hormone Antagonists Phase 4
10 Anti-Inflammatory Agents Phase 4
11 Gastrointestinal Agents Phase 4
12 Antiemetics Phase 4
13 Methylprednisolone Acetate Phase 4
14 Neuroprotective Agents Phase 4
15 Antineoplastic Agents, Hormonal Phase 4
16 Protective Agents Phase 4
17 Proxymetacaine Phase 4
18 Pharmaceutical Solutions Phase 2, Phase 3
19 Ophthalmic Solutions Phase 2, Phase 3
20 Lubricant Eye Drops Phase 2, Phase 3
21 Cyclosporins Phase 2, Phase 3
22
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
23
Bupivacaine Approved, Investigational Phase 2 38396-39-3, 2180-92-9 2474
24
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 2 53-43-0 5881
25 Adjuvants, Immunologic Phase 2
26 DHEA (Dehydroepiandrosterone) Phase 2
27 Androgens Phase 2
28 Neurotransmitter Agents Phase 2
29 abobotulinumtoxinA Phase 2
30 Cholinergic Agents Phase 2
31 Botulinum Toxins, Type A Phase 2
32 Botulinum Toxins Phase 2
33 Anesthetics Phase 2
34 Anesthetics, Local Phase 2
35
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
36
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
37 BB 1101 Phase 1
38
Iodine Approved, Investigational 7553-56-2 807
39
Lidocaine Approved, Vet_approved 137-58-6 3676
40
Cadexomer iodine Experimental 94820-09-4
41 Emollients
42 Benoxinate
43 Hemostatics

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Prospective Clinical Evaluation of Dacryocystorhinostomy (DCR) With Lacrimal Intubation Completed NCT01010659 Phase 4
2 The Role of Anterior Segment Optical Coherence Tomography in Management of Acquired Punctal Stenosis Completed NCT04318652 Phase 4 Methylprednisolone eyedrops
3 Does Administration of Proparacaine Hydrochloride 0.5% Ophthalmic Solution Prior to Canalicular Probing and Irrigation Decrease Patient Discomfort Recruiting NCT04229771 Phase 4 Proparacaine Hydrochloride ophthalmic solution, USP 0.5%;Balanced salt solution
4 Comparison of Autologous Serum 20% and Autologous Serum 50% for the Treatment of Severe Dry Eye Unknown status NCT03436576 Phase 3 Autologous Serum 20%;Autologous Serum 50%
5 Topical Cyclosporine-A for Management of Epiphora in Eyes With Acquired Punctal Stenosis Completed NCT04637633 Phase 2, Phase 3 topical 0.05% CsA (Restasis®, Allergan Inc, Irvine, California)twice daily dose,
6 Dehydroepiandrosterone (DHEA) Treatment for Sjogren's Syndrome Completed NCT00001598 Phase 2 Dehydroepiandrosterone
7 Determination of the Optimum Delivery Route for the Intraglandular Administration of Botulinum Toxin A in Patients With Refractory Epiphora Completed NCT01282541 Phase 2 Botulinum Toxin Type A;Botulinum Toxin Type A
8 Improving Epiphora & Ptosis With Bupivacaine Suspended NCT03266081 Phase 2 0.75% bupivacaine
9 A Double-Blind Study Evaluating the Safety and Efficacy of Cyclosporine Ophthalmic Emulsion 0.05% [Restasis] in Subjects With Epiphora Secondary to Docetaxel [Taxotere] Treatment for Various Cancers Withdrawn NCT00824811 Phase 2 Cyclosporine Eye Drops (Restasis);Lubricant Eye Drops (Refresh Enduraâ„¢);Fluorometholone Eye Drops (FML Forte®)
10 A Double Blind Interventional Study of the Efficacy of Topical Eye Treatment in the Prevention of Docetaxel Induced Dacryostenosis Completed NCT00266838 Phase 1 Maxidex; Lacrystat
11 Lacrimal Drainage System Obstruction Associated to Radioactive Iodine Therapy for Thyroid Carcinoma Unknown status NCT01579344 Radioiodine therapy
12 Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome (OCT) Unknown status NCT02849093
13 Long Term Follow up of Nasolacrimal Intubation in Adults With Mild Epiphora Completed NCT00706251
14 Symptomatic Acquired Lacrimal Passage Obstruction: Clinical Evaluation of the Level of Obstruction in Adult Patients of Upper Egypt Completed NCT04240431
15 Lacrimal Sac Dacryoliths (86 Samples): Chemical and Mineralogic Analyses Completed NCT01826734
16 A Simple Surgical Approach for the Management of Acquired Severe Lower Punctual Stenosis Completed NCT03731143
17 Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops Completed NCT03706443
18 The Efficacy of Punctal Dilatation With Insertion of Perforated Punctal Plugs for the Management of Acquired Punctal Stenosis Due to Allergic Conjunctivitis Completed NCT02503956
19 Adult Encysted Dacryocystocele: Prevalence Among Patients With Epiphora and Its Management Completed NCT04240938
20 The Sinopsys Lacrimal Stent Used During the Repair of the Lacrimal System in Patients With Epiphora Completed NCT02240615 Early Phase 1
21 Lacrimal Drainage Resistance Study Completed NCT01766232
22 Safety and Efficacy of the Slit Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction Recruiting NCT03705000
23 Innovative Imaging of the Conjunctiva, Cornea, and Ocular Adnexa : Study of a Handheld in Vivo Confocal Microscope and of a Fluorescent in Vivo Confocal Microscope Recruiting NCT02386774
24 A Comparison Between Placement of Three Interrupted Sutures After Triangular Three-snip Punctoplasty vs Conventional Triangular Three-snip Punctoplasty for Treatment of Lower Punctal Stenosis Active, not recruiting NCT04680078

Search NIH Clinical Center for Lacrimal Apparatus Disease

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Genetic Tests for Lacrimal Apparatus Disease

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Anatomical Context for Lacrimal Apparatus Disease

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MalaCards organs/tissues related to Lacrimal Apparatus Disease:

40
Eye, Bone, Skin, Lung, Heart, Liver, Thymus
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Publications for Lacrimal Apparatus Disease

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Articles related to Lacrimal Apparatus Disease:

# Title Authors PMID Year
1
[Disorders of the Lacrimal Apparatus, Part 2: Basics of Therapy]. 61
32314340 2020
2
[Laryngeoscopic approach for Lacrimal Apparatus Diseases]. 61
26591016 2015
3
[Endoscopic dacryocystorhinostomy]. 61
20629424 2010
4
[Application of endoscopic operation in ophthalmology]. 61
14740551 2003
5
[High resolution functional magnetic resonance tomography with Gd-DTPA eyedrops in diagnosis of lacrimal apparatus diseases]. 61
9782730 1998
6
[The hollow probe in the diagnosis and therapy of lacrimal apparatus diseases]. 61
639135 1978
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Variations for Lacrimal Apparatus Disease

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Expression for Lacrimal Apparatus Disease

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Search GEO for disease gene expression data for Lacrimal Apparatus Disease.
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Pathways for Lacrimal Apparatus Disease

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Pathways related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14 TRIM21 TNF MUC5AC MUC4 MMP9 IL6
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.35 TRIM21 TNF MMP9 IL6 IL1B IL17A
3
PAK Pathway 63
Show member pathways
 13.3 TNF IL6 IL1B IL17A CXCL8 CD4
4
Allograft rejection 36 1
Show member pathways
 12.82 TNF IL6 IL1B IL17A ICOSLG CXCL8
5
T cell receptor signaling pathway 36
Show member pathways
 12.61 TNF IL6 IL1B IL17A CD4
6
Th17 cell differentiation 36
Show member pathways
 12.6 TNF IL6 IL1B IL17A CD4
7
Immune response IL-23 signaling pathway 23
Show member pathways
 12.59 TNF IL6 IL1B IL17A CD4
8
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.33 TNF IL6 CXCL8 CCR6
9
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.27 TNF IL6 IL1B IL17A CXCL8
10
NOD-like receptor signaling pathway 36
12.24 TNF IL6 IL1B CXCL8
11
IL-1 Family Signaling Pathways 64
Show member pathways
 12.21 TNF MUC5AC IL6 IL1B CXCL8
12
Bacterial infections in CF airways 23
Show member pathways
 12.2 TNF IL6 IL1B CXCL8
13
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.18 TNF IL6 IL1B CXCL8
14
Yersinia infection 36
12.03 TNF IL6 IL1B CXCL8 CD4
15
TNF signaling pathway 36
11.98 TNF MMP9 IL6 IL1B
16
Spinal Cord Injury 1
11.95 TNF MMP9 IL6 IL1B CXCL8
17
Amoebiasis 36
11.93 TNF IL6 IL1B CXCL8
18
AGE-RAGE signaling pathway in diabetic complications 36
11.92 TNF IL6 IL1B CXCL8
19
Hematopoietic cell lineage 36
11.91 TNF IL6 IL1B CD4
20
Th17 Differentiation Pathway 64
Show member pathways
 11.87 IL6 IL1B IL17A CD4
21
Rheumatoid arthritis 36
11.8 TNF IL6 IL1B IL17A CXCL8
22
Pertussis 36
11.77 TNF IL6 IL1B CXCL8
23
Dendritic Cells Developmental Lineage Pathway 64
11.75 TNF IL6 IL1B CD4
24
LPA receptor mediated events 1
11.68 MMP9 IL6 CXCL8
25
IgA-Producing B Cells in the Intestine 64
11.68 TNF IL6 ICOSLG CCR6
26
Innate Lymphoid Cell Differentiation Pathways 64
11.67 TNF IL1B IL17A CD4 CCR6
27
Legionellosis 36
11.6 TNF IL6 IL1B CXCL8
28
Th1 Differentiation Pathway 64
Show member pathways
 11.6 TNF IL6 IL1B IL17A CD4
29
amb2 Integrin signaling 1
11.53 TNF MMP9 IL6
30
Malaria 36
11.52 TNF IL6 IL1B CXCL8
31
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.5 TNF IL6 IL1B
32
Interleukin-10 signaling 65
11.5 TNF IL6 IL1B CXCL8
33
IL-17 Family Signaling Pathways 64
Show member pathways
 11.5 TNF MUC5AC MMP9 IL6 IL1B IL17A
34
Interleukin-4 and 13 signaling 65
11.49 TNF MMP9 IL6 IL1B IL17A CXCL8
35
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.45 TNF MMP9 IL6 IL1B CXCL8
36
African trypanosomiasis 36
11.39 TNF IL6 IL1B
37
IL-10 Pathway 63
11.37 TNF IL6 IL1B
38
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.35 MMP9 IL6 CXCL8
39
Lung fibrosis 1
11.35 TNF MMP9 IL6 IL1B CXCL8
40
Antifolate resistance 36
11.3 TNF IL6 IL1B
41
Development and heterogeneity of the ILC family 1
11.26 TNF IL6 IL1B IL17A
42
Cytokines and Inflammatory Response 1
11.17 TNF IL6 IL1B CD4
43
Overview of nanoparticle effects 1
11.05 TNF IL6 CXCL8
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GO Terms for Lacrimal Apparatus Disease

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Cellular components related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNF PRR4 MUC5AC MUC4 MMP9 LCN1
2 external side of plasma membrane GO:0009897 9.55 TNF IL17A ICOSLG CD4 CCR6
3 extracellular space GO:0005615 9.4 TNF PRR4 MUC5AC MUC4 MMP9 LCN1

Biological processes related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.96 TNF IL6 IL1B IL17A CXCL8
2 positive regulation of protein phosphorylation GO:0001934 9.88 TNF MMP9 IL1B CD4
3 cellular response to lipopolysaccharide GO:0071222 9.84 TNF IL6 IL1B CXCL8
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 TRIM21 TNF IL6 IL1B
5 regulation of insulin secretion GO:0050796 9.78 TNF IL6 IL1B
6 positive regulation of T cell proliferation GO:0042102 9.77 IL6 IL1B CD4
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.76 TRIM21 TNF IL6 IL1B
8 positive regulation of interleukin-8 production GO:0032757 9.75 TNF IL6 IL1B
9 humoral immune response GO:0006959 9.74 TNF IL6 CCR6
10 positive regulation of interleukin-1 beta production GO:0032731 9.72 TNF IL6 IL17A
11 immune response GO:0006955 9.7 TNF IL6 IL1B IL17A CXCL8 CD4
12 positive regulation of interleukin-6 production GO:0032755 9.67 TNF IL6 IL1B IL17A
13 regulation of neuroinflammatory response GO:0150077 9.62 MMP9 IL6
14 regulation of establishment of endothelial barrier GO:1903140 9.61 TNF IL1B
15 negative regulation of neurogenesis GO:0050768 9.61 TNF IL6 IL1B
16 negative regulation of lipid storage GO:0010888 9.6 TNF IL6
17 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.58 TNF IL6 IL17A
18 positive regulation of fever generation GO:0031622 9.52 TNF IL1B
19 positive regulation of glial cell proliferation GO:0060252 9.5 TNF IL6 IL1B
20 sequestering of triglyceride GO:0030730 9.49 TNF IL1B
21 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 TNF IL1B
22 positive regulation of neuroinflammatory response GO:0150078 9.43 TNF IL6 IL1B
23 cytokine-mediated signaling pathway GO:0019221 9.17 TNF MMP9 IL6 IL1B IL17A CXCL8
24 vascular endothelial growth factor production GO:0010573 9.13 TNF IL6 IL1B

Molecular functions related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF IL6 IL1B IL17A CXCL8
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Sources for Lacrimal Apparatus Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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