Lacrimal Apparatus Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LCR008 MIFTS: 39	Lacrimal Apparatus Disease Categories: Eye diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Lacrimal Apparatus Disease

MalaCards integrated aliases for Lacrimal Apparatus Disease:

Name: Lacrimal Apparatus Disease ¹¹ ¹⁴ ¹⁶

Lacrimal Apparatus Diseases ⁷¹

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the eye and adnexa

Disorders of eyelid, lacrimal system and orbit

Disorders of lacrimal system

ICD11: ³³

Diseases of the visual system

Disorders of the ocular adnexa or orbit

Disorders of lacrimal apparatus

Disorders of lacrimal apparatus, unspecified

Other specified disorders of lacrimal apparatus

External Ids:

Disease Ontology ¹¹ DOID:1400

ICD9CM ³⁴ 375

MeSH ⁴³ D007766

NCIt ⁴⁹ C26809

SNOMED-CT ⁶⁸ 267740009

ICD10 ³¹ H04

EFO ¹⁶ EFO_0009455

ICD11 ³³ 1628710366 1628710366/other 1628710366/unspecified

UMLS ⁷¹ C0022904

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Summaries for Lacrimal Apparatus Disease

Disease Ontology: ¹¹ An eye disease that affects the lacrimal apparatus (the lacrimal gland and its related structures) which moisten and drain the eye.

MalaCards based summary: Lacrimal Apparatus Disease, also known as lacrimal apparatus diseases, is related to dry eye syndrome and chronic inflammation of lacrimal passage, and has symptoms including visual disturbance, eye manifestations and dacryops. An important gene associated with Lacrimal Apparatus Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include eye and thyroid, and related phenotypes are digestive/alimentary and immune system

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Related Diseases for Lacrimal Apparatus Disease

Diseases in the Lacrimal Apparatus Disease family:

Rare Disorder of the Lacrimal Apparatus

Diseases related to Lacrimal Apparatus Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 717)

#	Related Disease	Score	Top Affiliating Genes
1	dry eye syndrome	30.4	TRPM8 TRIM21 TNF SSB PRR4 P2RY2
2	chronic inflammation of lacrimal passage	11.2
3	keratoconjunctivitis	10.4	TRIM21 TNF MUC5AC
4	external pathological resorption	10.4	TNF IL6
5	chronic atticoantral disease	10.4	TNF MUC5AC
6	diffuse infiltrative lymphocytosis syndrome	10.4	TRIM21 SSB CD4
7	apperceptive agnosia	10.4	LCN1 LACRT
8	histiocytosis	10.4	TNF IL17A CCR6
9	pollen allergy	10.4	ICOSLG CD4 CCR6
10	immunodeficiency 14	10.4	ICOSLG CD4 CCR6
11	orbital cellulitis	10.4	LACRT IL6 CD4
12	acute orbital inflammation	10.4	LACRT IL6 CD4
13	igg4-related disease	10.4	ICOSLG CD4 CCR6
14	immunodeficiency 16	10.4	ICOSLG CD4 CCR6
15	legume allergy	10.4	ICOSLG CD4 CCR6
16	fruit allergy	10.4	ICOSLG CD4 CCR6
17	drug-induced lupus erythematosus	10.4	TRIM21 TNF SSB
18	nonspecific interstitial pneumonia	10.4	TRIM21 CD4 CCR6
19	peanut allergy	10.4	ICOSLG CD4 CCR6
20	enterocolitis	10.4	TNF IL6 CXCL8
21	physiological polycythemia	10.4	TNF IL6 IL1B
22	ischemic colitis	10.4	TNF IL6 CCR6
23	autoimmune pancreatitis	10.4	ICOSLG CD4 CCR6
24	multicentric castleman disease	10.4	IL6 CD4 CCR6
25	accommodative spasm	10.4	P2RY2 LACRT AQP5
26	castleman disease	10.4	IL6 CD4 CCR6
27	senile entropion	10.4	TNF CXCL8
28	esophageal candidiasis	10.4	IL17A CD4 CCR6
29	subcutaneous mycosis	10.4	IL17A CD4 CCR6
30	pericoronitis	10.4	TNF IL6 IL1B
31	chronic apical periodontitis	10.4	TNF IL6 IL1B
32	pernicious anemia	10.4	ICOSLG CD4 CCR6
33	cicatricial entropion	10.4	LCN1 LACRT
34	miller fisher syndrome	10.4	TNF IL6 CCR6
35	farmer's lung	10.4	TNF CD4 CCR6
36	tinea pedis	10.4	IL17A CD4 CCR6
37	autoimmune cholangitis	10.4	IL17A CD4 CCR6
38	angioimmunoblastic t-cell lymphoma	10.4	ICOSLG CD4 CCR6
39	immunoglobulin alpha deficiency	10.4	ICOSLG CD4 CCR6
40	acute disseminated encephalomyelitis	10.4	IL6 CD4 CCR6
41	frozen shoulder	10.4	TNF IL6 IL1B
42	mesenteric lymphadenitis	10.4	TNF IL6 IL1B
43	periodontitis, chronic	10.4	IL6 IL1B
44	acute retinal necrosis syndrome	10.4	TNF IL6 CD4
45	chancroid	10.4	CXCL8 CD4 CCR6
46	inflammatory and toxic neuropathy	10.4	TNF IL6 IL1B
47	graves ophthalmopathy	10.4	TNF IL6 IL1B
48	viral exanthem	10.4	TNF IL6 CD4
49	tuberculoid leprosy	10.4	TNF CD4 CCR6
50	acute necrotizing pancreatitis	10.4	TNF IL6 IL1B

Graphical network of the top 20 diseases related to Lacrimal Apparatus Disease:

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Symptoms & Phenotypes for Lacrimal Apparatus Disease

UMLS symptoms related to Lacrimal Apparatus Disease:

visual disturbance; eye manifestations; dacryops

MGI Mouse Phenotypes related to Lacrimal Apparatus Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.56	AQP5 CD4 IL17A IL6 MMP9 MUC4
2	immune system	MP:0005387	9.4	CCR6 CD4 ICOSLG IL17A IL1B IL6

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Drugs & Therapeutics for Lacrimal Apparatus Disease

Drugs for Lacrimal Apparatus Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

4894 5755

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

1875

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

4159 6741

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

4897

Ophthalmic Solutions

Phase 4

Pharmaceutical Solutions

Phase 4

Hormones

Phase 4

Hormone Antagonists

Phase 4

Anti-Inflammatory Agents

Phase 4

glucocorticoids

Phase 4

Antineoplastic Agents, Hormonal

Phase 4

Neuroprotective Agents

Phase 4

Antiemetics

Phase 4

Methylprednisolone Acetate

Phase 4

584547

Gastrointestinal Agents

Phase 4

Protective Agents

Phase 4

Proxymetacaine

Phase 4

Lubricant Eye Drops

Phase 2, Phase 3

Cyclosporins

Phase 2, Phase 3

Acetylcholine

Approved, Investigational

Phase 2

51-84-3

187

Prasterone

Approved, Investigational, Nutraceutical

Phase 2

53-43-0

5881

Adjuvants, Immunologic

Phase 2

Androgens

Phase 2

DHEA (Dehydroepiandrosterone)

Phase 2

Neurotransmitter Agents

Phase 2

abobotulinumtoxinA

Phase 2

Botulinum Toxins, Type A

Phase 2

Botulinum Toxins

Phase 2

Cholinergic Agents

Phase 2

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 1

1177-87-3

3680

Dexamethasone

Approved, Investigational, Vet_approved

Phase 1

50-02-2

3003 5743

BB 1101

Phase 1

Iodine

Approved, Investigational

7553-56-2

807

Lidocaine

Approved, Vet_approved

137-58-6

3676

Oxybuprocaine

Approved, Investigational

99-43-4

4633

Cadexomer iodine

Experimental

94820-09-4

Hemostatics

Emollients

Interventional clinical trials:

(show all 27)

#	Name	Status	NCT ID	Phase	Drugs
1	The Role of Anterior Segment Optical Coherence Tomography in Management of Acquired Punctal Stenosis	Completed	NCT04318652	Phase 4	Methylprednisolone eyedrops
2	Prospective Clinical Evaluation of Dacryocystorhinostomy (DCR) With Lacrimal Intubation	Completed	NCT01010659	Phase 4
3	Does Administration of Proparacaine Hydrochloride 0.5% Ophthalmic Solution Prior to Canalicular Probing and Irrigation Decrease Patient Discomfort	Recruiting	NCT04229771	Phase 4	Proparacaine Hydrochloride ophthalmic solution, USP 0.5%;Balanced salt solution
4	Comparison of Autologous Serum 20% and Autologous Serum 50% for the Treatment of Severe Dry Eye	Unknown status	NCT03436576	Phase 3	Autologous Serum 20%;Autologous Serum 50%
5	Topical Cyclosporine-A for Management of Epiphora in Eyes With Acquired Punctal Stenosis	Completed	NCT04637633	Phase 2, Phase 3	topical 0.05% CsA (Restasis®, Allergan Inc, Irvine, California)twice daily dose,
6	Dehydroepiandrosterone (DHEA) Treatment for Sjogren's Syndrome	Completed	NCT00001598	Phase 2	Dehydroepiandrosterone
7	Determination of the Optimum Delivery Route for the Intraglandular Administration of Botulinum Toxin A in Patients With Refractory Epiphora	Completed	NCT01282541	Phase 2	Botulinum Toxin Type A
8	A Double-Blind Study Evaluating the Safety and Efficacy of Cyclosporine Ophthalmic Emulsion 0.05% [Restasis] in Subjects With Epiphora Secondary to Docetaxel [Taxotere] Treatment for Various Cancers	Withdrawn	NCT00824811	Phase 2	Cyclosporine Eye Drops (Restasis);Lubricant Eye Drops (Refresh Endura™);Fluorometholone Eye Drops (FML Forte®)
9	Improving Epiphora & Ptosis With Bupivacaine	Withdrawn	NCT03266081	Phase 2	0.75% bupivacaine
10	A Double Blind Interventional Study of the Efficacy of Topical Eye Treatment in the Prevention of Docetaxel Induced Dacryostenosis	Completed	NCT00266838	Phase 1	Maxidex; Lacrystat
11	Lacrimal Drainage System Obstruction Associated to Radioactive Iodine Therapy for Thyroid Carcinoma	Unknown status	NCT01579344		Radioiodine therapy
12	A Comparison Between Placement of Three Interrupted Sutures After Triangular Three-snip Punctoplasty vs Conventional Triangular Three-snip Punctoplasty for Treatment of Lower Punctal Stenosis	Unknown status	NCT04680078
13	Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome (OCT)	Unknown status	NCT02849093
14	Long Term Follow up of Nasolacrimal Intubation in Adults With Mild Epiphora	Completed	NCT00706251
15	Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops	Completed	NCT03706443
16	Symptomatic Acquired Lacrimal Passage Obstruction: Clinical Evaluation of the Level of Obstruction in Adult Patients of Upper Egypt	Completed	NCT04240431
17	Lacrimal Sac Dacryoliths (86 Samples): Chemical and Mineralogic Analyses	Completed	NCT01826734
18	Adult Encysted Dacryocystocele: Prevalence Among Patients With Epiphora and Its Management	Completed	NCT04240938
19	The Sinopsys Lacrimal Stent Used During the Repair of the Lacrimal System in Patients With Epiphora	Completed	NCT02240615	Early Phase 1
20	A Simple Surgical Approach for the Management of Acquired Severe Lower Punctual Stenosis	Completed	NCT03731143
21	The Efficacy of Punctal Dilatation With Insertion of Perforated Punctal Plugs for the Management of Acquired Punctal Stenosis Due to Allergic Conjunctivitis	Completed	NCT02503956
22	Non-endoscopic Endonasal, Transcanalicular, or External Dacryocystorhinostomy for Functional Epiphora: Which is Better?	Completed	NCT04952454
23	Lacrimal Drainage Resistance Study	Completed	NCT01766232
24	Innovative Imaging of the Conjunctiva, Cornea, and Ocular Adnexa : Study of a Handheld in Vivo Confocal Microscope and of a Fluorescent in Vivo Confocal Microscope	Recruiting	NCT02386774
25	Design of an Augmented Reality System by Integration of CT Scan or MRI Data With Endoscopic Images for Video-assisted Endonasal Endoscopic Surgery	Recruiting	NCT04968561
26	Safety and Efficacy of the Slit Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction	Recruiting	NCT03705000
27	Comparative Study Between Wide and Narrow Fenstrum Endoscopic DCR	Active, not recruiting	NCT04833452

Search NIH Clinical Center for Lacrimal Apparatus Disease

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Genetic Tests for Lacrimal Apparatus Disease

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Anatomical Context for Lacrimal Apparatus Disease

Organs/tissues related to Lacrimal Apparatus Disease:

MalaCards : Eye, Thyroid

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Publications for Lacrimal Apparatus Disease

Articles related to Lacrimal Apparatus Disease:

#	Title	Authors	PMID	Year
1	[Endoscopic dacryocystorhinostomy]. ⁶²	Milojevic M...Peric A	20629424	2010
2	[Application of endoscopic operation in ophthalmology]. ⁶²	Huang S...Yu M	14740551	2003

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Genes for Lacrimal Apparatus Disease

Genes related to Lacrimal Apparatus Disease (0 elite genes):

(show all 35)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	9.31	DISEASES inferred ¹⁴ ¹⁴
2	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	7.82	DISEASES inferred ¹⁴ ¹⁴
3	LACRT	Lacritin	Protein Coding	7.42	DISEASES inferred ¹⁴
4	TRIM21	Tripartite Motif Containing 21	Protein Coding	7.38	DISEASES inferred ¹⁴
5	SSB	Small RNA Binding Exonuclease Protection Factor La	Protein Coding	7.28	DISEASES inferred ¹⁴
6	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	7.18	DISEASES inferred ¹⁴
7	LCN1	Lipocalin 1	Protein Coding	6.98	DISEASES inferred ¹⁴
8	IL6	Interleukin 6	Protein Coding	6.92	DISEASES inferred ¹⁴
9	IL1B	Interleukin 1 Beta	Protein Coding	6.9	DISEASES inferred ¹⁴
10	CD4	CD4 Molecule	Protein Coding	6.88	DISEASES inferred ¹⁴
11	P2RY2	Purinergic Receptor P2Y2	Protein Coding	6.85	DISEASES inferred ¹⁴
12	TNF	Tumor Necrosis Factor	Protein Coding	6.85	DISEASES inferred ¹⁴
13	IL17A	Interleukin 17A	Protein Coding	6.84	DISEASES inferred ¹⁴
14	AQP5	Aquaporin 5	Protein Coding	6.79	DISEASES inferred ¹⁴
15	MMP9	Matrix Metallopeptidase 9	Protein Coding	6.69	DISEASES inferred ¹⁴
16	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	6.54	DISEASES inferred ¹⁴
17	BPIFA2	BPI Fold Containing Family A Member 2	Protein Coding	6.46	DISEASES inferred ¹⁴
18	TRPM8	Transient Receptor Potential Cation Channel Subfamily M Member 8	Protein Coding	6.42	DISEASES inferred ¹⁴
19	MUC4	Mucin 4, Cell Surface Associated	Protein Coding	6.39	DISEASES inferred ¹⁴
20	PRR4	Proline Rich 4	Protein Coding	6.37	DISEASES inferred ¹⁴
21	RO60	Ro60, Y RNA Binding Protein	Protein Coding	6.34	DISEASES inferred ¹⁴
22	IL10	Interleukin 10	Protein Coding	6.3	DISEASES inferred ¹⁴
23	MUC16	Mucin 16, Cell Surface Associated	Protein Coding	6.28	DISEASES inferred ¹⁴
24	NGF	Nerve Growth Factor	Protein Coding	6.27	DISEASES inferred ¹⁴
25	CD8A	CD8a Molecule	Protein Coding	6.14	DISEASES inferred ¹⁴
26	CRYAA	Crystallin Alpha A	Protein Coding	6.14	DISEASES inferred ¹⁴ ¹⁴
27	IL1A	Interleukin 1 Alpha	Protein Coding	6.13	DISEASES inferred ¹⁴
28	SPTAN1	Spectrin Alpha, Non-Erythrocytic 1	Protein Coding	6.12	DISEASES inferred ¹⁴
29	TAC1	Tachykinin Precursor 1	Protein Coding	6.1	DISEASES inferred ¹⁴
30	EGF	Epidermal Growth Factor	Protein Coding	6.09	DISEASES inferred ¹⁴
31	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	6.08	DISEASES inferred ¹⁴
32	IL4	Interleukin 4	Protein Coding	6.07	DISEASES inferred ¹⁴
33	IL2	Interleukin 2	Protein Coding	6.05	DISEASES inferred ¹⁴
34	SERPINA3	Serpin Family A Member 3	Protein Coding	6.05	DISEASES inferred ¹⁴ ¹⁴
35	TNFSF13B	TNF Superfamily Member 13b	Protein Coding	6.02	DISEASES inferred ¹⁴

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Variations for Lacrimal Apparatus Disease

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Expression for Lacrimal Apparatus Disease

Search GEO for disease gene expression data for Lacrimal Apparatus Disease.

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Pathways for Lacrimal Apparatus Disease

Pathways related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

(show all 46)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.92	BPIFA2 CCR6 CD4 CXCL8 ICOSLG IL17A
2	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.61	TNF MMP9 IL6 IL1B IL17A CXCL8
3	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.38	CCR6 CD4 CXCL8 IL17A IL1B IL6
4	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.29	TRIM21 TNF MMP9 IL6 IL1B IL17A
5	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.26	TNF IL6 IL1B IL17A CXCL8 CD4
6	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.81	TNF MMP9 IL6 IL1B CXCL8
7	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways IL1 signaling pathway ⁶⁷ Immune response IL-1 signaling pathway ²² Interleukin-1 (IL-1) structural pathway ⁷⁴ Interleukin-33 signaling ⁶⁶ Interleukin-36 pathway ⁶⁶ Mucin expression in CF via TLRs, EGFR signaling pathways ²² Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.59	CXCL8 IL1B IL6 MUC5AC TNF
8	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.56	TNF IL6 IL1B IL17A CD4
9	Toll-Like receptor Signaling Pathways ⁶⁵ Show member pathways Inflammasome Activation Pathways ⁶⁵ Nanomaterial-induced inflammasome activation ⁷⁴ NOD-like Receptor Signaling Pathways ⁶⁵ TLR4 signaling and tolerance ⁷⁴ Toll-Like Receptors Pathway ⁶⁴	12.47	TNF IL6 IL1B CXCL8
10	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.38	TNF IL6 IL1B CXCL8
11	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.29	TNF IL6 IL1B CXCL8
12	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ⁶⁷ IL-17 signaling pathway ⁷⁴ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.17	TNF MUC5AC MMP9 IL6 IL17A CXCL8
13	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.14	TNF IL6 IL1B CXCL8
14	Spinal cord injury ⁷⁴	11.99	TNF MMP9 IL6 IL1B CXCL8
15	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.92	TNF IL6 IL1B IL17A CD4
16	Allograft rejection ⁷⁴	11.87	CXCL8 IL17A IL1B TNF
17	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.85	IL6 IL1B IL17A CD4
18	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.75	TNF IL6 IL1B CD4
19	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.74	IL6 CXCL8 CD4
20	Acute viral myocarditis ⁷⁴	11.72	MMP9 IL6 CD4
21	Th17 cell differentiation pathway ⁷⁴	11.71	IL6 IL1B IL17A CD4
22	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.69	TNF IL6 ICOSLG
23	AP-1 transcription factor network ⁶¹	11.68	CXCL8 IL6 MMP9
24	Innate Lymphoid Cells Differentiation ⁶⁵	11.67	TNF IL1B IL17A CD4 CCR6
25	miRNAs involvement in the immune response in sepsis ⁷⁴	11.63	TNF IL6 CXCL8
26	IL 10 signaling pathway ⁶⁷	11.62	TNF IL6 IL1B
27	Burn wound healing ⁷⁴	11.59	CXCL8 IL1B IL6 MMP9 TNF
28	Non-genomic actions of 1,25 dihydroxyvitamin D3 ⁷⁴	11.53	TNF IL6 CXCL8
29	Interleukin-10 signaling ⁶⁶	11.52	TNF IL6 IL1B CXCL8
30	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.47	TNF IL6 IL1B
31	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.47	TNF MMP9 IL6 IL1B IL17A CXCL8
32	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.45	TNF MMP9 IL6 IL1B CXCL8
33	Lung fibrosis ⁷⁴	11.35	TNF MMP9 IL6 IL1B CXCL8
34	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ⁶¹	11.34	MMP9 IL6 CXCL8
35	IL-10 Pathway ⁶⁴	11.34	TNF IL6 IL1B
36	Development and heterogeneity of the ILC family ⁷⁴	11.32	TNF IL6 IL1B IL17A
37	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	11.26	TNF IL6 IL1B CXCL8
38	amb2 Integrin signaling ⁶¹	11.25	TNF MMP9 IL6
39	Cytokines and inflammatory response ⁷⁴	11.22	TNF IL6 IL1B CD4
40	Immune infiltration in pancreatic cancer ⁷⁴	11.17	TNF IL6 IL17A CXCL8
41	Overview of nanoparticle effects ⁷⁴	11.04	TNF IL6 CXCL8
42	G-protein signaling_Rap2B regulation pathway ²²	10.99	TNF IL6 IL1B IL17A CXCL8
43	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.77	IL6 IL1B
44	COVID-19 adverse outcome pathway ⁷⁴	10.68	IL6 CXCL8
45	Prostaglandin signaling ⁷⁴	10.55	TNF MMP9 IL6 IL1B IL17A CXCL8
46	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.37	CXCL8 IL6 TNF

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GO Terms for Lacrimal Apparatus Disease

Cellular components related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	10.28	TRPM8 TNF P2RY2 MUC4 CD4 CCR6
2	plasma membrane	GO:0005887	10.28	TRPM8 TNF P2RY2 MUC4 CD4 CCR6
3	extracellular region	GO:0005576	9.98	BPIFA2 CXCL8 IL17A IL1B IL6 LACRT
4	external side of plasma membrane	GO:0009897	9.93	CCR6 CD4 ICOSLG IL17A TNF TRPM8
5	extracellular space	GO:0005615	9.7	TNF PRR4 MUC5AC MUC4 MMP9 LCN1

Biological processes related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	defense response to Gram-positive bacterium	GO:0050830	10.13	TNF IL6 IL1B IL17A
2	positive regulation of DNA-binding transcription factor activity	GO:0051091	10.11	IL1B IL6 TNF TRIM21
3	positive regulation of interleukin-6 production	GO:0032755	10.06	TNF IL6 IL1B IL17A
4	regulation of insulin secretion	GO:0050796	10.03	TNF IL6 IL1B
5	immune response	GO:0006955	10	CCR6 CD4 CXCL8 IL17A IL1B IL6
6	positive regulation of chemokine production	GO:0032722	9.95	TNF IL6 IL1B
7	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.88	IL17A IL6 TNF
8	negative regulation of neurogenesis	GO:0050768	9.85	TNF IL6 IL1B
9	positive regulation of fever generation	GO:0031622	9.84	TNF IL1B
10	sequestering of triglyceride	GO:0030730	9.8	TNF IL1B
11	positive regulation of glial cell proliferation	GO:0060252	9.8	TNF IL6 IL1B
12	leukocyte migration	GO:0050900	9.78	TNF MMP9 IL1B
13	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.73	TNF IL1B
14	positive regulation of neuroinflammatory response	GO:0150078	9.63	TNF IL6 IL1B
15	vascular endothelial growth factor production	GO:0010573	9.43	TNF IL6 IL1B
16	calcium-mediated signaling	GO:0019722	9.4	TRPM8 TNF LACRT CXCL8 CD4 CCR6