MCID: LCR008
MIFTS: 39

Lacrimal Apparatus Disease

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Lacrimal Apparatus Disease

MalaCards integrated aliases for Lacrimal Apparatus Disease:

Name: Lacrimal Apparatus Disease 12 15 17
Lacrimal Apparatus Diseases 71

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:1400
ICD9CM 34 375 375.9
MeSH 43 D007766
NCIt 49 C26809
SNOMED-CT 67 31053003
ICD10 32 H04 H04.9
UMLS 71 C0022904

Summaries for Lacrimal Apparatus Disease

Disease Ontology : 12 An eye disease that affects the lacrimal apparatus (the lacrimal gland and its related structures) which moisten and drain the eye.

MalaCards based summary : Lacrimal Apparatus Disease, also known as lacrimal apparatus diseases, is related to excessive tearing and chronic inflammation of lacrimal passage, and has symptoms including visual disturbance, eye manifestations and dacryops. An important gene associated with Lacrimal Apparatus Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Allograft rejection and IL-17 Family Signaling Pathways. The drugs Acetylcholine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and skin, and related phenotype is digestive/alimentary.

Wikipedia : 74 The lacrimal apparatus is the physiological system containing the orbital structures for tear production... more...

Related Diseases for Lacrimal Apparatus Disease

Diseases in the Lacrimal Apparatus Disease family:

Rare Disorder of the Lacrimal Apparatus

Diseases related to Lacrimal Apparatus Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 348)
# Related Disease Score Top Affiliating Genes
1 excessive tearing 33.4 LCN1 DCXR
2 chronic inflammation of lacrimal passage 11.4
3 external pathological resorption 10.6 TNF IL6
4 mononeuritis of upper limb and mononeuritis multiplex 10.6 TRIM21 SSB CD4
5 mononeuritis multiplex 10.6 TRIM21 SSB CD4
6 parotid disease 10.6 TRIM21 SSB CD4
7 mikulicz disease 10.6 ICOSLG CD4 CCR6
8 hyperglobulinemic purpura 10.6 TRIM21 HSPG2
9 autoimmune glomerulonephritis 10.6 ICOSLG CD4 CCR6
10 nut allergy 10.6 ICOSLG CD4 CCR6
11 scorpion envenomation 10.6 TNF IL6
12 senile ectropion 10.6 MUC5AC MMP9 DCXR
13 subacute cutaneous lupus erythematosus 10.6 TRIM21 TNF
14 thrombocytopenia due to platelet alloimmunization 10.6 ICOSLG CD4 CCR6
15 igg4-related disease 10.6 ICOSLG CD4 CCR6
16 autoimmune disease of skin and connective tissue 10.6 ICOSLG CD4 CCR6
17 primary thrombocytopenia 10.6 ICOSLG CD4 CCR6
18 dermatophytosis 10.6 IL17A CD4 CCR6
19 coccidioidomycosis 10.6 IL17A CD4 CCR6
20 immunoglobulin alpha deficiency 10.6 ICOSLG CD4 CCR6
21 intestinal schistosomiasis 10.6 IL17A CD4 CCR6
22 chronic follicular conjunctivitis 10.5 PRR4 LCN1 LACRT
23 autoimmune inner ear disease 10.5 TNF MMP9
24 acute transverse myelitis 10.5 MMP9 IL6
25 bullous skin disease 10.5 ICOSLG CD4 CCR6
26 t cell deficiency 10.5 IL17A CD4 CCR6
27 plasma protein metabolism disease 10.5 IL6 CD4 CCR6
28 limited scleroderma 10.5 TRIM21 SSB CCR6
29 thymus gland disease 10.5 ICOSLG CD4 CCR6
30 thymus cancer 10.5 ICOSLG CD4 CCR6
31 corneal ulcer 10.5 MUC5AC MMP9 LACRT
32 idiopathic anterior uveitis 10.5 TNF IL6
33 hypopyon 10.5 IL6 IL17A CD4
34 oral candidiasis 10.5 IL17A CD4 CCR6
35 thrombocytopenic purpura, autoimmune 10.5 ICOSLG CD4 CCR6
36 autoimmune vasculitis 10.5 TNF CD4 CCR6
37 streptococcal toxic-shock syndrome 10.5 TNF IL6
38 syphilis 10.5 IL17A CD4 CCR6
39 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 TNF IL6
40 pustulosis of palm and sole 10.5 TNF IL17A CCR6
41 systemic autoimmune disease 10.5 MMP9 IL6 IL17A
42 diabetes mellitus, insulin-dependent, 23 10.5 TNF CD4
43 lymphatic system cancer 10.5 ICOSLG CD4 CCR6
44 dental pulp disease 10.5 TNF IL6 CCR6
45 palladium allergic contact dermatitis 10.5 TNF IL17A
46 uveoparotid fever 10.5 TNF SSB CD4
47 colonic benign neoplasm 10.5 IL6 IL17A CCR6
48 histoplasmosis 10.5 TNF CD4 CCR6
49 conjunctivitis 10.5 TNF MMP9 IL6
50 cecal disease 10.5 TNF IL6 CCR6

Graphical network of the top 20 diseases related to Lacrimal Apparatus Disease:



Diseases related to Lacrimal Apparatus Disease

Symptoms & Phenotypes for Lacrimal Apparatus Disease

UMLS symptoms related to Lacrimal Apparatus Disease:


visual disturbance, eye manifestations, dacryops

MGI Mouse Phenotypes related to Lacrimal Apparatus Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.23 AQP5 CD4 HSPG2 IL17A IL6 MMP9

Drugs & Therapeutics for Lacrimal Apparatus Disease

Drugs for Lacrimal Apparatus Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
2
Bupivacaine Approved, Investigational Phase 2 38396-39-3, 2180-92-9 2474
3
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 2 53-43-0 9860744
4 Adjuvants, Immunologic Phase 2
5 DHEA (Dehydroepiandrosterone) Phase 2
6 Androgens Phase 2
7 abobotulinumtoxinA Phase 2
8 Neurotransmitter Agents Phase 2
9 Acetylcholine Release Inhibitors Phase 2
10 Botulinum Toxins Phase 2
11 Neuromuscular Agents Phase 2
12 Cholinergic Agents Phase 2
13 Botulinum Toxins, Type A Phase 2
14 Anesthetics, Local Phase 2
15 Anesthetics Phase 2
16 Central Nervous System Depressants Phase 2
17
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
18
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
19
protease inhibitors Phase 1
20 Antiemetics Phase 1
21 BB 1101 Phase 1
22 Gastrointestinal Agents Phase 1
23 HIV Protease Inhibitors Phase 1
24 Autonomic Agents Phase 1
25 Antineoplastic Agents, Hormonal Phase 1
26
Iodine Approved, Investigational 7553-56-2 807
27 Nutrients
28 Anti-Infective Agents, Local
29 Trace Elements
30 Micronutrients
31 cadexomer iodine
32 Emollients
33 Benoxinate

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Prospective Clinical Evaluation of Dacryocystorhinostomy (DCR) With Lacrimal Intubation Completed NCT01010659 Phase 4
2 Comparison of Autologous Serum 20% and Autologous Serum 50% for the Treatment of Severe Dry Eye Enrolling by invitation NCT03436576 Phase 3 Autologous Serum 20%;Autologous Serum 50%
3 Dehydroepiandrosterone (DHEA) Treatment for Sjogren's Syndrome Completed NCT00001598 Phase 2 Dehydroepiandrosterone
4 Determination of the Optimum Delivery Route for the Intraglandular Administration of Botulinum Toxin A in Patients With Refractory Epiphora Completed NCT01282541 Phase 2 Botulinum Toxin Type A;Botulinum Toxin Type A
5 An Adaptive Phase 2 Randomized Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Multiple LOU064 Doses in Patients With Moderate to Severe Sjögren's Syndrome (LOUiSSe) Recruiting NCT04035668 Phase 2 LOU064;Placebo
6 Improving Epiphora & Ptosis With Bupivacaine Suspended NCT03266081 Phase 2 0.75% bupivacaine
7 Pilot Study of a Homeopathic Therapy in Combination With Cyclosporin (Restasis) in the Treatment of Dry Eye Disease Terminated NCT01072526 Phase 2 Euphrasia-based homeopathic therapy;Cyclosporin solution
8 A Double-Blind Study Evaluating the Safety and Efficacy of Cyclosporine Ophthalmic Emulsion 0.05% [Restasis] in Subjects With Epiphora Secondary to Docetaxel [Taxotere] Treatment for Various Cancers Withdrawn NCT00824811 Phase 2 Cyclosporine Eye Drops (Restasis);Lubricant Eye Drops (Refresh Endura™);Fluorometholone Eye Drops (FML Forte®)
9 A Double Blind Interventional Study of the Efficacy of Topical Eye Treatment in the Prevention of Docetaxel Induced Dacryostenosis Completed NCT00266838 Phase 1 Maxidex; Lacrystat
10 Lacrimal Drainage System Obstruction Associated to Radioactive Iodine Therapy for Thyroid Carcinoma Unknown status NCT01579344 Radioiodine therapy
11 Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome (OCT) Unknown status NCT02849093
12 The Sinopsys Lacrimal Stent Used During the Repair of the Lacrimal System in Patients With Epiphora Completed NCT02240615 Early Phase 1
13 Long Term Follow up of Nasolacrimal Intubation in Adults With Mild Epiphora Completed NCT00706251
14 Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops Completed NCT03706443
15 Lacrimal Sac Dacryoliths (86 Samples): Chemical and Mineralogic Analyses Completed NCT01826734
16 A Simple Surgical Approach for the Management of Acquired Severe Lower Punctual Stenosis Completed NCT03731143
17 The Efficacy of Punctal Dilatation With Insertion of Perforated Punctal Plugs for the Management of Acquired Punctal Stenosis Due to Allergic Conjunctivitis Completed NCT02503956
18 Lacrimal Drainage Resistance Study Completed NCT01766232
19 Innovative Imaging of the Conjunctiva, Cornea, and Ocular Adnexa : Study of a Handheld in Vivo Confocal Microscope and of a Fluorescent in Vivo Confocal Microscope Recruiting NCT02386774
20 Safety and Efficacy of the Slit Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction Not yet recruiting NCT03705000

Search NIH Clinical Center for Lacrimal Apparatus Disease

Genetic Tests for Lacrimal Apparatus Disease

Anatomical Context for Lacrimal Apparatus Disease

MalaCards organs/tissues related to Lacrimal Apparatus Disease:

40
Eye, Bone, Skin, Lung, B Cells, Thymus, Spinal Cord

Publications for Lacrimal Apparatus Disease

Articles related to Lacrimal Apparatus Disease:

# Title Authors PMID Year
1
[Laryngeoscopic approach for Lacrimal Apparatus Diseases]. 61
26591016 2015
2
[Endoscopic dacryocystorhinostomy]. 61
20629424 2010
3
[Application of endoscopic operation in ophthalmology]. 61
14740551 2003
4
[High resolution functional magnetic resonance tomography with Gd-DTPA eyedrops in diagnosis of lacrimal apparatus diseases]. 61
9782730 1998
5
[The hollow probe in the diagnosis and therapy of lacrimal apparatus diseases]. 61
639135 1978

Variations for Lacrimal Apparatus Disease

Expression for Lacrimal Apparatus Disease

Search GEO for disease gene expression data for Lacrimal Apparatus Disease.

Pathways for Lacrimal Apparatus Disease

Pathways related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 TNF IL6 IL17A ICOSLG CD4
2
Show member pathways
11.89 TNF MUC5AC MMP9 IL6 IL17A
3
Show member pathways
11.85 TNF IL6 IL17A CD4
4
Show member pathways
11.81 TNF MMP9 IL6 HSPG2
5 11.68 TNF MMP9 IL6 IL17A
6 11.56 TNF IL6 CD4
7
Show member pathways
11.47 TNF MMP9 IL6
8 11.45 TNF MMP9 IL6
9 11.31 TNF MMP9 IL6
10 11.16 TNF IL17A CD4 CCR6
11 11.05 TNF IL6 IL17A
12 10.9 TNF IL6 CD4
13 10.78 TNF MMP9 IL6 IL17A

GO Terms for Lacrimal Apparatus Disease

Cellular components related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 TNF PRR4 MUC5AC MMP9 LCN1 LACRT
2 external side of plasma membrane GO:0009897 9.55 TNF IL17A ICOSLG CD4 CCR6
3 extracellular region GO:0005576 9.32 TNF PRR4 MUC5AC MMP9 LCN1 LACRT

Biological processes related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.77 TNF IL6 IL17A CD4 CCR6
2 positive regulation of neuroinflammatory response GO:0150078 9.4 TNF IL6
3 regulation of neuroinflammatory response GO:0150077 9.32 MMP9 IL6
4 positive regulation of viral entry into host cell GO:0046598 9.26 TRIM21 CD4
5 negative regulation of lipid storage GO:0010888 9.16 TNF IL6
6 humoral immune response GO:0006959 9.13 TNF IL6 CCR6
7 cytokine-mediated signaling pathway GO:0019221 9.02 TNF MMP9 IL6 IL17A CD4

Molecular functions related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.23 TRIM21 TNF MMP9 ICOSLG DCXR CRYAA

Sources for Lacrimal Apparatus Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....