MCID: LCR008
MIFTS: 40

Lacrimal Apparatus Disease

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Lacrimal Apparatus Disease

MalaCards integrated aliases for Lacrimal Apparatus Disease:

Name: Lacrimal Apparatus Disease 12 15 17
Lacrimal Apparatus Diseases 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1400
ICD9CM 34 375
MeSH 43 D007766
NCIt 49 C26809
SNOMED-CT 67 31053003
ICD10 32 H04
UMLS 71 C0022904

Summaries for Lacrimal Apparatus Disease

Disease Ontology : 12 An eye disease that affects the lacrimal apparatus (the lacrimal gland and its related structures) which moisten and drain the eye.

MalaCards based summary : Lacrimal Apparatus Disease, also known as lacrimal apparatus diseases, is related to excessive tearing and chronic inflammation of lacrimal passage, and has symptoms including visual disturbance, eye manifestations and dacryops. An important gene associated with Lacrimal Apparatus Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye and thyroid, and related phenotypes are digestive/alimentary and immune system

Wikipedia : 74 The lacrimal apparatus is the physiological system containing the orbital structures for tear production... more...

Related Diseases for Lacrimal Apparatus Disease

Diseases in the Lacrimal Apparatus Disease family:

Rare Disorder of the Lacrimal Apparatus

Diseases related to Lacrimal Apparatus Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 507)
# Related Disease Score Top Affiliating Genes
1 excessive tearing 12.0
2 chronic inflammation of lacrimal passage 11.4
3 physiological polycythemia 10.6 TNF IL1B
4 external pathological resorption 10.6 TNF IL6
5 diffuse infiltrative lymphocytosis syndrome 10.6 TRIM21 SSB CD4
6 scorpion envenomation 10.6 TNF IL6
7 parotid disease 10.6 TRIM21 SSB CD4
8 subacute cutaneous lupus erythematosus 10.6 TRIM21 TNF
9 anti-basement membrane glomerulonephritis 10.6 IL1B CD4 CCR6
10 systemic onset juvenile idiopathic arthritis 10.6 TNF IL1B
11 esophageal candidiasis 10.6 IL17A CD4 CCR6
12 subcutaneous mycosis 10.6 IL17A CD4 CCR6
13 dermatophytosis 10.6 IL17A CD4 CCR6
14 autoimmune inner ear disease 10.6 TNF MMP9
15 senile ectropion 10.6 MUC5AC MMP9 DCXR
16 mononeuropathy 10.6 TRIM21 TNF SSB
17 staphylococcal toxic shock syndrome 10.6 TNF IL1B
18 silo filler's disease 10.6 MUC5AC IL1B IL17A
19 pustulosis of palm and sole 10.6 TNF IL17A CCR6
20 idiopathic anterior uveitis 10.6 TNF IL6
21 prosthetic joint infection 10.6 IL6 IL1B
22 retinal vasculitis 10.6 TNF CD4 CCR6
23 filamentary keratitis 10.6 MUC5AC LACRT BPIFA2
24 legume allergy 10.6 ICOSLG CD4 CCR6
25 fruit allergy 10.6 ICOSLG CD4 CCR6
26 seborrheic dermatitis 10.6 TNF CD4 CCR6
27 paratyphoid fever 10.6 TNF IL1B CCR6
28 periodontitis, chronic 10.6 IL6 IL1B
29 autoimmune polyendocrine syndrome type 1 10.6 IL17A CD4 CCR6
30 primary thrombocytopenia 10.5 ICOSLG CD4 CCR6
31 autoimmune polyendocrine syndrome 10.5 IL1B IL17A CCR6
32 palladium allergic contact dermatitis 10.5 TNF IL1B IL17A
33 nasopharyngitis 10.5 TNF IL17A CCR6
34 igg4-related disease 10.5 ICOSLG CD4 CCR6
35 limited scleroderma 10.5 TRIM21 SSB CCR6
36 folliculitis 10.5 TNF CD4 CCR6
37 streptococcal toxic-shock syndrome 10.5 TNF IL6
38 crohn's colitis 10.5 TNF IL1B CCR6
39 immunoglobulin alpha deficiency 10.5 ICOSLG CD4 CCR6
40 anemia, autoimmune hemolytic 10.5 ICOSLG CD4 CCR6
41 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 TNF IL6
42 oral candidiasis 10.5 IL17A CD4 CCR6
43 pneumonic plague 10.5 TNF IL17A CD4
44 vulvar vestibulitis syndrome 10.5 TNF IL1B
45 anaerobic pneumonia 10.5 TNF IL6 IL1B
46 conjunctivitis 10.5 TNF MMP9 IL6
47 stachybotrys chartarum 10.5 TNF IL6 IL1B
48 intermediate uveitis 10.5 TNF IL6 CCR6
49 hemorrhagic cystitis 10.5 TNF IL1B CD4
50 choroiditis 10.5 TNF IL17A CD4

Graphical network of the top 20 diseases related to Lacrimal Apparatus Disease:



Diseases related to Lacrimal Apparatus Disease

Symptoms & Phenotypes for Lacrimal Apparatus Disease

UMLS symptoms related to Lacrimal Apparatus Disease:


visual disturbance, eye manifestations, dacryops

MGI Mouse Phenotypes related to Lacrimal Apparatus Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.56 AQP5 CD4 HSPG2 IL17A IL6 MMP9
2 immune system MP:0005387 9.36 CCR6 CD4 HSPG2 IL17A IL1B IL6

Drugs & Therapeutics for Lacrimal Apparatus Disease

Drugs for Lacrimal Apparatus Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
7 Methylprednisolone Acetate Phase 4
8 Antineoplastic Agents, Hormonal Phase 4
9 Neuroprotective Agents Phase 4
10 Antiemetics Phase 4
11 Protective Agents Phase 4
12 Gastrointestinal Agents Phase 4
13 Anesthetics Phase 4
14 Anesthetics, Local Phase 4
15 Proxymetacaine Phase 4
16
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
17
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
18
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 2 53-43-0 9860744
19 Adjuvants, Immunologic Phase 2
20 Androgens Phase 2
21 DHEA (Dehydroepiandrosterone) Phase 2
22 abobotulinumtoxinA Phase 2
23 Cholinergic Agents Phase 2
24 Botulinum Toxins Phase 2
25 Botulinum Toxins, Type A Phase 2
26 Neurotransmitter Agents Phase 2
27
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
28
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
29 BB 1101 Phase 1
30
Iodine Approved, Investigational 7553-56-2 807
31 cadexomer iodine
32 Emollients
33 Benoxinate

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 The Role of Anterior Segment Optical Coherence Tomography in Management of Acquired Punctal Stenosis Completed NCT04318652 Phase 4 Methylprednisolone eyedrops
2 Prospective Clinical Evaluation of Dacryocystorhinostomy (DCR) With Lacrimal Intubation Completed NCT01010659 Phase 4
3 Does Administration of Proparacaine Hydrochloride 0.5% Ophthalmic Solution Prior to Canalicular Probing and Irrigation Decrease Patient Discomfort Not yet recruiting NCT04229771 Phase 4 Proparacaine Hydrochloride ophthalmic solution, USP 0.5%;Balanced salt solution
4 Comparison of Autologous Serum 20% and Autologous Serum 50% for the Treatment of Severe Dry Eye Enrolling by invitation NCT03436576 Phase 3 Autologous Serum 20%;Autologous Serum 50%
5 Dehydroepiandrosterone (DHEA) Treatment for Sjogren's Syndrome Completed NCT00001598 Phase 2 Dehydroepiandrosterone
6 Determination of the Optimum Delivery Route for the Intraglandular Administration of Botulinum Toxin A in Patients With Refractory Epiphora Completed NCT01282541 Phase 2 Botulinum Toxin Type A;Botulinum Toxin Type A
7 An Adaptive Phase 2 Randomized Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Multiple LOU064 Doses in Patients With Moderate to Severe Sjögren's Syndrome (LOUiSSe) Recruiting NCT04035668 Phase 2 LOU064;Placebo
8 Improving Epiphora & Ptosis With Bupivacaine Suspended NCT03266081 Phase 2 0.75% bupivacaine
9 Pilot Study of a Homeopathic Therapy in Combination With Cyclosporin (Restasis) in the Treatment of Dry Eye Disease Terminated NCT01072526 Phase 2 Euphrasia-based homeopathic therapy;Cyclosporin solution
10 A Double-Blind Study Evaluating the Safety and Efficacy of Cyclosporine Ophthalmic Emulsion 0.05% [Restasis] in Subjects With Epiphora Secondary to Docetaxel [Taxotere] Treatment for Various Cancers Withdrawn NCT00824811 Phase 2 Cyclosporine Eye Drops (Restasis);Lubricant Eye Drops (Refresh Endura™);Fluorometholone Eye Drops (FML Forte®)
11 A Double Blind Interventional Study of the Efficacy of Topical Eye Treatment in the Prevention of Docetaxel Induced Dacryostenosis Completed NCT00266838 Phase 1 Maxidex; Lacrystat
12 Lacrimal Drainage System Obstruction Associated to Radioactive Iodine Therapy for Thyroid Carcinoma Unknown status NCT01579344 Radioiodine therapy
13 Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome (OCT) Unknown status NCT02849093
14 Symptomatic Acquired Lacrimal Passage Obstruction: Clinical Evaluation of the Level of Obstruction in Adult Patients of Upper Egypt Completed NCT04240431
15 Adult Encysted Dacryocystocele: Prevalence Among Patients With Epiphora and Its Management Completed NCT04240938
16 The Sinopsys Lacrimal Stent Used During the Repair of the Lacrimal System in Patients With Epiphora Completed NCT02240615 Early Phase 1
17 Long Term Follow up of Nasolacrimal Intubation in Adults With Mild Epiphora Completed NCT00706251
18 Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops Completed NCT03706443
19 Lacrimal Sac Dacryoliths (86 Samples): Chemical and Mineralogic Analyses Completed NCT01826734
20 A Simple Surgical Approach for the Management of Acquired Severe Lower Punctual Stenosis Completed NCT03731143
21 The Efficacy of Punctal Dilatation With Insertion of Perforated Punctal Plugs for the Management of Acquired Punctal Stenosis Due to Allergic Conjunctivitis Completed NCT02503956
22 Lacrimal Drainage Resistance Study Completed NCT01766232
23 Innovative Imaging of the Conjunctiva, Cornea, and Ocular Adnexa : Study of a Handheld in Vivo Confocal Microscope and of a Fluorescent in Vivo Confocal Microscope Recruiting NCT02386774
24 Safety and Efficacy of the Slit Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction Not yet recruiting NCT03705000

Search NIH Clinical Center for Lacrimal Apparatus Disease

Genetic Tests for Lacrimal Apparatus Disease

Anatomical Context for Lacrimal Apparatus Disease

MalaCards organs/tissues related to Lacrimal Apparatus Disease:

40
Eye, Thyroid

Publications for Lacrimal Apparatus Disease

Articles related to Lacrimal Apparatus Disease:

# Title Authors PMID Year
1
[Disorders of the Lacrimal Apparatus, Part 2: Basics of Therapy]. 61
32314340 2020
2
[Laryngeoscopic approach for Lacrimal Apparatus Diseases]. 61
26591016 2015
3
[Endoscopic dacryocystorhinostomy]. 61
20629424 2010
4
[Application of endoscopic operation in ophthalmology]. 61
14740551 2003
5
[High resolution functional magnetic resonance tomography with Gd-DTPA eyedrops in diagnosis of lacrimal apparatus diseases]. 61
9782730 1998
6
[The hollow probe in the diagnosis and therapy of lacrimal apparatus diseases]. 61
639135 1978

Variations for Lacrimal Apparatus Disease

Expression for Lacrimal Apparatus Disease

Search GEO for disease gene expression data for Lacrimal Apparatus Disease.

Pathways for Lacrimal Apparatus Disease

Pathways related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 TRIM21 TNF MUC5AC MMP9 IL6 IL1B
2
Show member pathways
13.29 TRIM21 TNF MMP9 IL6 IL1B IL17A
3
Show member pathways
12.76 TNF IL6 IL1B IL17A ICOSLG CD4
4
Show member pathways
12.54 TNF IL6 IL1B IL17A CD4
5
Show member pathways
12.53 TNF IL6 IL1B IL17A CD4
6
Show member pathways
12.51 TNF IL6 IL1B IL17A CD4
7
Show member pathways
12.07 TNF MUC5AC MMP9 IL6 IL1B IL17A
8 11.94 TNF MMP9 IL6 IL1B
9 11.87 TNF MMP9 IL6 IL1B
10 11.82 TNF MMP9 IL6 IL1B IL17A
11 11.81 TNF IL6 IL1B CD4
12 11.76 TNF IL6 IL1B IL17A
13
Show member pathways
11.74 IL6 IL1B IL17A CD4
14
Show member pathways
11.74 TNF IL6 IL1B IL17A CD4
15 11.69 TNF IL6 IL1B
16 11.63 TNF IL6 IL1B CD4
17 11.56 TNF IL6 IL1B
18
Show member pathways
11.53 TNF MMP9 IL6 IL1B
19 11.5 TNF IL6 IL1B
20 11.5 TNF MMP9 IL6 IL1B
21 11.48 TNF IL6 IL1B
22 11.47 TNF MMP9 IL6
23 11.43 TNF IL6 IL1B
24 11.32 TNF IL6 IL1B
25 11.29 TNF IL6 IL1B
26 11.22 TNF IL6 IL1B
27 10.96 TNF IL6 IL1B IL17A
28 10.92 TNF IL1B IL17A CD4 CCR6
29 10.72 TNF IL6 IL1B CD4

GO Terms for Lacrimal Apparatus Disease

Cellular components related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 TNF MUC5AC MMP9 LCN1 LACRT IL6
2 external side of plasma membrane GO:0009897 9.55 TNF IL17A ICOSLG CD4 CCR6
3 extracellular space GO:0005615 9.28 TNF MUC5AC MMP9 LCN1 LACRT IL6

Biological processes related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 TNF IL6 IL1B IL17A HSPG2
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.86 TRIM21 TNF IL1B CD4
3 positive regulation of protein phosphorylation GO:0001934 9.85 TNF MMP9 IL1B CD4
4 immune response GO:0006955 9.85 TNF IL6 IL1B IL17A CD4 CCR6
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 TRIM21 TNF IL6 IL1B
6 positive regulation of T cell proliferation GO:0042102 9.75 IL6 IL1B CD4
7 humoral immune response GO:0006959 9.74 TNF IL6 CCR6
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.71 TRIM21 TNF IL6 IL1B
9 positive regulation of interleukin-6 production GO:0032755 9.7 TNF IL6 IL1B
10 positive regulation of interleukin-6 secretion GO:2000778 9.65 TNF IL1B IL17A
11 regulation of neuroinflammatory response GO:0150077 9.61 MMP9 IL6
12 positive regulation of viral entry into host cell GO:0046598 9.61 TRIM21 CD4
13 negative regulation of lipid storage GO:0010888 9.6 TNF IL6
14 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.59 TNF IL17A
15 regulation of establishment of endothelial barrier GO:1903140 9.58 TNF IL1B
16 positive regulation of fever generation GO:0031622 9.51 TNF IL1B
17 negative regulation of neurogenesis GO:0050768 9.5 TNF IL6 IL1B
18 sequestering of triglyceride GO:0030730 9.46 TNF IL1B
19 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 TNF IL1B
20 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.43 TNF IL6 IL17A
21 positive regulation of glial cell proliferation GO:0060252 9.33 TNF IL6 IL1B
22 positive regulation of neuroinflammatory response GO:0150078 9.13 TNF IL6 IL1B
23 cytokine-mediated signaling pathway GO:0019221 9.1 TNF MMP9 IL6 IL1B IL17A CD4

Molecular functions related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IL6 IL1B IL17A
2 identical protein binding GO:0042802 9.23 TRIM21 TNF MMP9 ICOSLG DCXR CRYAA

Sources for Lacrimal Apparatus Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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