MCID: LCR008
MIFTS: 39

Lacrimal Apparatus Disease

Categories: Eye diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Lacrimal Apparatus Disease

Summaries for Lacrimal Apparatus Disease

Disease Ontology: 11 An eye disease that affects the lacrimal apparatus (the lacrimal gland and its related structures) which moisten and drain the eye.

MalaCards based summary: Lacrimal Apparatus Disease, also known as lacrimal apparatus diseases, is related to dry eye syndrome and chronic inflammation of lacrimal passage, and has symptoms including visual disturbance, eye manifestations and dacryops. An important gene associated with Lacrimal Apparatus Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include eye and thyroid, and related phenotypes are digestive/alimentary and immune system

Related Diseases for Lacrimal Apparatus Disease

Diseases in the Lacrimal Apparatus Disease family:

Rare Disorder of the Lacrimal Apparatus

Diseases related to Lacrimal Apparatus Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 717)
# Related Disease Score Top Affiliating Genes
1 dry eye syndrome 30.4 TRPM8 TRIM21 TNF SSB PRR4 P2RY2
2 chronic inflammation of lacrimal passage 11.2
3 keratoconjunctivitis 10.4 TRIM21 TNF MUC5AC
4 external pathological resorption 10.4 TNF IL6
5 chronic atticoantral disease 10.4 TNF MUC5AC
6 diffuse infiltrative lymphocytosis syndrome 10.4 TRIM21 SSB CD4
7 apperceptive agnosia 10.4 LCN1 LACRT
8 histiocytosis 10.4 TNF IL17A CCR6
9 pollen allergy 10.4 ICOSLG CD4 CCR6
10 immunodeficiency 14 10.4 ICOSLG CD4 CCR6
11 orbital cellulitis 10.4 LACRT IL6 CD4
12 acute orbital inflammation 10.4 LACRT IL6 CD4
13 igg4-related disease 10.4 ICOSLG CD4 CCR6
14 immunodeficiency 16 10.4 ICOSLG CD4 CCR6
15 legume allergy 10.4 ICOSLG CD4 CCR6
16 fruit allergy 10.4 ICOSLG CD4 CCR6
17 drug-induced lupus erythematosus 10.4 TRIM21 TNF SSB
18 nonspecific interstitial pneumonia 10.4 TRIM21 CD4 CCR6
19 peanut allergy 10.4 ICOSLG CD4 CCR6
20 enterocolitis 10.4 TNF IL6 CXCL8
21 physiological polycythemia 10.4 TNF IL6 IL1B
22 ischemic colitis 10.4 TNF IL6 CCR6
23 autoimmune pancreatitis 10.4 ICOSLG CD4 CCR6
24 multicentric castleman disease 10.4 IL6 CD4 CCR6
25 accommodative spasm 10.4 P2RY2 LACRT AQP5
26 castleman disease 10.4 IL6 CD4 CCR6
27 senile entropion 10.4 TNF CXCL8
28 esophageal candidiasis 10.4 IL17A CD4 CCR6
29 subcutaneous mycosis 10.4 IL17A CD4 CCR6
30 pericoronitis 10.4 TNF IL6 IL1B
31 chronic apical periodontitis 10.4 TNF IL6 IL1B
32 pernicious anemia 10.4 ICOSLG CD4 CCR6
33 cicatricial entropion 10.4 LCN1 LACRT
34 miller fisher syndrome 10.4 TNF IL6 CCR6
35 farmer's lung 10.4 TNF CD4 CCR6
36 tinea pedis 10.4 IL17A CD4 CCR6
37 autoimmune cholangitis 10.4 IL17A CD4 CCR6
38 angioimmunoblastic t-cell lymphoma 10.4 ICOSLG CD4 CCR6
39 immunoglobulin alpha deficiency 10.4 ICOSLG CD4 CCR6
40 acute disseminated encephalomyelitis 10.4 IL6 CD4 CCR6
41 frozen shoulder 10.4 TNF IL6 IL1B
42 mesenteric lymphadenitis 10.4 TNF IL6 IL1B
43 periodontitis, chronic 10.4 IL6 IL1B
44 acute retinal necrosis syndrome 10.4 TNF IL6 CD4
45 chancroid 10.4 CXCL8 CD4 CCR6
46 inflammatory and toxic neuropathy 10.4 TNF IL6 IL1B
47 graves ophthalmopathy 10.4 TNF IL6 IL1B
48 viral exanthem 10.4 TNF IL6 CD4
49 tuberculoid leprosy 10.4 TNF CD4 CCR6
50 acute necrotizing pancreatitis 10.4 TNF IL6 IL1B

Graphical network of the top 20 diseases related to Lacrimal Apparatus Disease:



Diseases related to Lacrimal Apparatus Disease

Symptoms & Phenotypes for Lacrimal Apparatus Disease

UMLS symptoms related to Lacrimal Apparatus Disease:


visual disturbance; eye manifestations; dacryops

MGI Mouse Phenotypes related to Lacrimal Apparatus Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.56 AQP5 CD4 IL17A IL6 MMP9 MUC4
2 immune system MP:0005387 9.4 CCR6 CD4 ICOSLG IL17A IL1B IL6

Drugs & Therapeutics for Lacrimal Apparatus Disease

Drugs for Lacrimal Apparatus Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 4894 5755
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5 1875
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 4159 6741
6
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7 4897
7 Ophthalmic Solutions Phase 4
8 Pharmaceutical Solutions Phase 4
9 Hormones Phase 4
10 Hormone Antagonists Phase 4
11 Anti-Inflammatory Agents Phase 4
12 glucocorticoids Phase 4
13 Antineoplastic Agents, Hormonal Phase 4
14 Neuroprotective Agents Phase 4
15 Antiemetics Phase 4
16
Methylprednisolone Acetate Phase 4 584547
17 Gastrointestinal Agents Phase 4
18 Protective Agents Phase 4
19 Proxymetacaine Phase 4
20 Lubricant Eye Drops Phase 2, Phase 3
21 Cyclosporins Phase 2, Phase 3
22
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
23
Prasterone Approved, Investigational, Nutraceutical Phase 2 53-43-0 5881
24 Adjuvants, Immunologic Phase 2
25 Androgens Phase 2
26 DHEA (Dehydroepiandrosterone) Phase 2
27 Neurotransmitter Agents Phase 2
28
abobotulinumtoxinA Phase 2
29 Botulinum Toxins, Type A Phase 2
30 Botulinum Toxins Phase 2
31 Cholinergic Agents Phase 2
32
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3 3680
33
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 3003 5743
34 BB 1101 Phase 1
35
Iodine Approved, Investigational 7553-56-2 807
36
Lidocaine Approved, Vet_approved 137-58-6 3676
37
Oxybuprocaine Approved, Investigational 99-43-4 4633
38
Cadexomer iodine Experimental 94820-09-4
39 Hemostatics
40 Emollients

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 The Role of Anterior Segment Optical Coherence Tomography in Management of Acquired Punctal Stenosis Completed NCT04318652 Phase 4 Methylprednisolone eyedrops
2 Prospective Clinical Evaluation of Dacryocystorhinostomy (DCR) With Lacrimal Intubation Completed NCT01010659 Phase 4
3 Does Administration of Proparacaine Hydrochloride 0.5% Ophthalmic Solution Prior to Canalicular Probing and Irrigation Decrease Patient Discomfort Recruiting NCT04229771 Phase 4 Proparacaine Hydrochloride ophthalmic solution, USP 0.5%;Balanced salt solution
4 Comparison of Autologous Serum 20% and Autologous Serum 50% for the Treatment of Severe Dry Eye Unknown status NCT03436576 Phase 3 Autologous Serum 20%;Autologous Serum 50%
5 Topical Cyclosporine-A for Management of Epiphora in Eyes With Acquired Punctal Stenosis Completed NCT04637633 Phase 2, Phase 3 topical 0.05% CsA (Restasis®, Allergan Inc, Irvine, California)twice daily dose,
6 Dehydroepiandrosterone (DHEA) Treatment for Sjogren's Syndrome Completed NCT00001598 Phase 2 Dehydroepiandrosterone
7 Determination of the Optimum Delivery Route for the Intraglandular Administration of Botulinum Toxin A in Patients With Refractory Epiphora Completed NCT01282541 Phase 2 Botulinum Toxin Type A
8 A Double-Blind Study Evaluating the Safety and Efficacy of Cyclosporine Ophthalmic Emulsion 0.05% [Restasis] in Subjects With Epiphora Secondary to Docetaxel [Taxotere] Treatment for Various Cancers Withdrawn NCT00824811 Phase 2 Cyclosporine Eye Drops (Restasis);Lubricant Eye Drops (Refresh Endura™);Fluorometholone Eye Drops (FML Forte®)
9 Improving Epiphora & Ptosis With Bupivacaine Withdrawn NCT03266081 Phase 2 0.75% bupivacaine
10 A Double Blind Interventional Study of the Efficacy of Topical Eye Treatment in the Prevention of Docetaxel Induced Dacryostenosis Completed NCT00266838 Phase 1 Maxidex; Lacrystat
11 Lacrimal Drainage System Obstruction Associated to Radioactive Iodine Therapy for Thyroid Carcinoma Unknown status NCT01579344 Radioiodine therapy
12 A Comparison Between Placement of Three Interrupted Sutures After Triangular Three-snip Punctoplasty vs Conventional Triangular Three-snip Punctoplasty for Treatment of Lower Punctal Stenosis Unknown status NCT04680078
13 Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome (OCT) Unknown status NCT02849093
14 Long Term Follow up of Nasolacrimal Intubation in Adults With Mild Epiphora Completed NCT00706251
15 Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops Completed NCT03706443
16 Symptomatic Acquired Lacrimal Passage Obstruction: Clinical Evaluation of the Level of Obstruction in Adult Patients of Upper Egypt Completed NCT04240431
17 Lacrimal Sac Dacryoliths (86 Samples): Chemical and Mineralogic Analyses Completed NCT01826734
18 Adult Encysted Dacryocystocele: Prevalence Among Patients With Epiphora and Its Management Completed NCT04240938
19 The Sinopsys Lacrimal Stent Used During the Repair of the Lacrimal System in Patients With Epiphora Completed NCT02240615 Early Phase 1
20 A Simple Surgical Approach for the Management of Acquired Severe Lower Punctual Stenosis Completed NCT03731143
21 The Efficacy of Punctal Dilatation With Insertion of Perforated Punctal Plugs for the Management of Acquired Punctal Stenosis Due to Allergic Conjunctivitis Completed NCT02503956
22 Non-endoscopic Endonasal, Transcanalicular, or External Dacryocystorhinostomy for Functional Epiphora: Which is Better? Completed NCT04952454
23 Lacrimal Drainage Resistance Study Completed NCT01766232
24 Innovative Imaging of the Conjunctiva, Cornea, and Ocular Adnexa : Study of a Handheld in Vivo Confocal Microscope and of a Fluorescent in Vivo Confocal Microscope Recruiting NCT02386774
25 Design of an Augmented Reality System by Integration of CT Scan or MRI Data With Endoscopic Images for Video-assisted Endonasal Endoscopic Surgery Recruiting NCT04968561
26 Safety and Efficacy of the Slit Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction Recruiting NCT03705000
27 Comparative Study Between Wide and Narrow Fenstrum Endoscopic DCR Active, not recruiting NCT04833452

Search NIH Clinical Center for Lacrimal Apparatus Disease

Genetic Tests for Lacrimal Apparatus Disease

Anatomical Context for Lacrimal Apparatus Disease

Organs/tissues related to Lacrimal Apparatus Disease:

MalaCards : Eye, Thyroid

Publications for Lacrimal Apparatus Disease

Articles related to Lacrimal Apparatus Disease:

# Title Authors PMID Year
1
[Endoscopic dacryocystorhinostomy]. 62
20629424 2010
2
[Application of endoscopic operation in ophthalmology]. 62
14740551 2003

Variations for Lacrimal Apparatus Disease

Expression for Lacrimal Apparatus Disease

Search GEO for disease gene expression data for Lacrimal Apparatus Disease.

Pathways for Lacrimal Apparatus Disease

Pathways related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 BPIFA2 CCR6 CD4 CXCL8 ICOSLG IL17A
2
Show member pathways
13.61 TNF MMP9 IL6 IL1B IL17A CXCL8
3
Show member pathways
13.38 CCR6 CD4 CXCL8 IL17A IL1B IL6
4
Show member pathways
13.29 TRIM21 TNF MMP9 IL6 IL1B IL17A
5
Show member pathways
13.26 TNF IL6 IL1B IL17A CXCL8 CD4
6
Show member pathways
12.81 TNF MMP9 IL6 IL1B CXCL8
7
Show member pathways
12.59 CXCL8 IL1B IL6 MUC5AC TNF
8
Show member pathways
12.56 TNF IL6 IL1B IL17A CD4
9
Show member pathways
12.47 TNF IL6 IL1B CXCL8
10
Show member pathways
12.38 TNF IL6 IL1B CXCL8
11
Show member pathways
12.29 TNF IL6 IL1B CXCL8
12
Show member pathways
12.17 TNF MUC5AC MMP9 IL6 IL17A CXCL8
13 12.14 TNF IL6 IL1B CXCL8
14 11.99 TNF MMP9 IL6 IL1B CXCL8
15
Show member pathways
11.92 TNF IL6 IL1B IL17A CD4
16 11.87 CXCL8 IL17A IL1B TNF
17
Show member pathways
11.85 IL6 IL1B IL17A CD4
18 11.75 TNF IL6 IL1B CD4
19
Show member pathways
11.74 IL6 CXCL8 CD4
20 11.72 MMP9 IL6 CD4
21 11.71 IL6 IL1B IL17A CD4
22 11.69 TNF IL6 ICOSLG
23 11.68 CXCL8 IL6 MMP9
24 11.67 TNF IL1B IL17A CD4 CCR6
25 11.63 TNF IL6 CXCL8
26 11.62 TNF IL6 IL1B
27 11.59 CXCL8 IL1B IL6 MMP9 TNF
28 11.53 TNF IL6 CXCL8
29 11.52 TNF IL6 IL1B CXCL8
30 11.47 TNF IL6 IL1B
31 11.47 TNF MMP9 IL6 IL1B IL17A CXCL8
32
Show member pathways
11.45 TNF MMP9 IL6 IL1B CXCL8
33 11.35 TNF MMP9 IL6 IL1B CXCL8
34 11.34 MMP9 IL6 CXCL8
35 11.34 TNF IL6 IL1B
36 11.32 TNF IL6 IL1B IL17A
37 11.26 TNF IL6 IL1B CXCL8
38 11.25 TNF MMP9 IL6
39 11.22 TNF IL6 IL1B CD4
40 11.17 TNF IL6 IL17A CXCL8
41 11.04 TNF IL6 CXCL8
42 10.99 TNF IL6 IL1B IL17A CXCL8
43 10.77 IL6 IL1B
44 10.68 IL6 CXCL8
45 10.55 TNF MMP9 IL6 IL1B IL17A CXCL8
46
Show member pathways
10.37 CXCL8 IL6 TNF

GO Terms for Lacrimal Apparatus Disease

Cellular components related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.28 TRPM8 TNF P2RY2 MUC4 CD4 CCR6
2 plasma membrane GO:0005887 10.28 TRPM8 TNF P2RY2 MUC4 CD4 CCR6
3 extracellular region GO:0005576 9.98 BPIFA2 CXCL8 IL17A IL1B IL6 LACRT
4 external side of plasma membrane GO:0009897 9.93 CCR6 CD4 ICOSLG IL17A TNF TRPM8
5 extracellular space GO:0005615 9.7 TNF PRR4 MUC5AC MUC4 MMP9 LCN1

Biological processes related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 10.13 TNF IL6 IL1B IL17A
2 positive regulation of DNA-binding transcription factor activity GO:0051091 10.11 IL1B IL6 TNF TRIM21
3 positive regulation of interleukin-6 production GO:0032755 10.06 TNF IL6 IL1B IL17A
4 regulation of insulin secretion GO:0050796 10.03 TNF IL6 IL1B
5 immune response GO:0006955 10 CCR6 CD4 CXCL8 IL17A IL1B IL6
6 positive regulation of chemokine production GO:0032722 9.95 TNF IL6 IL1B
7 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.88 IL17A IL6 TNF
8 negative regulation of neurogenesis GO:0050768 9.85 TNF IL6 IL1B
9 positive regulation of fever generation GO:0031622 9.84 TNF IL1B
10 sequestering of triglyceride GO:0030730 9.8 TNF IL1B
11 positive regulation of glial cell proliferation GO:0060252 9.8 TNF IL6 IL1B
12 leukocyte migration GO:0050900 9.78 TNF MMP9 IL1B
13 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.73 TNF IL1B
14 positive regulation of neuroinflammatory response GO:0150078 9.63 TNF IL6 IL1B
15 vascular endothelial growth factor production GO:0010573 9.43 TNF IL6 IL1B
16 calcium-mediated signaling GO:0019722 9.4 TRPM8 TNF LACRT CXCL8 CD4 CCR6

Molecular functions related to Lacrimal Apparatus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 TNF IL6 IL1B IL17A CXCL8

Sources for Lacrimal Apparatus Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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