MCID: LCR001
MIFTS: 26

Lacrimal Duct Obstruction

Categories: Neuronal diseases

Aliases & Classifications for Lacrimal Duct Obstruction

MalaCards integrated aliases for Lacrimal Duct Obstruction:

Name: Lacrimal Duct Obstruction 12 6 44 15
Obstruction of Lacrimal Canaliculus 12
Obstruction of Lacrimal Ducts 12
Blocked Lacrimal Canaliculus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13929
MeSH 44 D007767
NCIt 50 C34757
SNOMED-CT 67 95769009
UMLS 70 C0022906

Summaries for Lacrimal Duct Obstruction

MalaCards based summary : Lacrimal Duct Obstruction, also known as obstruction of lacrimal canaliculus, is related to branchiooculofacial syndrome and growth retardation, deafness, femoral epiphyseal dysplasia, and lacrimal duct obstruction. An important gene associated with Lacrimal Duct Obstruction is HOXC13 (Homeobox C13). The drugs Ephedrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include eye, pituitary and kidney.

Related Diseases for Lacrimal Duct Obstruction

Graphical network of the top 20 diseases related to Lacrimal Duct Obstruction:



Diseases related to Lacrimal Duct Obstruction

Symptoms & Phenotypes for Lacrimal Duct Obstruction

Drugs & Therapeutics for Lacrimal Duct Obstruction

Drugs for Lacrimal Duct Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ephedrine Approved Phase 1, Phase 2 299-42-3 9294
2
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
3
Pseudoephedrine Approved Phase 1, Phase 2 90-82-4 7028
4
Tetracaine Approved, Vet_approved Phase 1, Phase 2 94-24-6 5411
5 Anesthetics Phase 1, Phase 2
6 Ether
7 Antibiotics, Antitubercular
8 Mitomycins
9 Alkylating Agents
10 Anti-Bacterial Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Comparative Study of Recessive Spherical Headed Silicone Intubation and Dacryocystorhinostomy Under Nasal Endoscopy in the Treatment of Nasolacrimal Duct Obstruction Completed NCT02636257 Phase 1, Phase 2
2 A Study to Develop a Protocol for Functional Magnetic Resonance Imaging of the Lacrimal Drainage System Unknown status NCT03411889
3 Risk and Importance of Peroperative Nasal Hemorrhage in the Treatment of Lacrimal Duct Obstruction in Young Children Completed NCT02851641
4 Lacrimal Sac Dacryoliths (86 Samples): Chemical and Mineralogic Analyses Completed NCT01826734
5 Long Term Effectiveness of Dacryocystorinostomy With and Without Bicanalicular Intubation Recruiting NCT03960996
6 Recovery After Endoscopic Dacryocystorhinostomy Active, not recruiting NCT00571129
7 Self-retaining Bicanalicular Intubation Stent Versus Bicanalicular Silicone Tube for Management of Canalicular Obstruction Not yet recruiting NCT04706117

Search NIH Clinical Center for Lacrimal Duct Obstruction

Cochrane evidence based reviews: lacrimal duct obstruction

Genetic Tests for Lacrimal Duct Obstruction

Anatomical Context for Lacrimal Duct Obstruction

MalaCards organs/tissues related to Lacrimal Duct Obstruction:

40
Eye, Pituitary, Kidney, Thyroid

Publications for Lacrimal Duct Obstruction

Articles related to Lacrimal Duct Obstruction:

(show top 50) (show all 140)
# Title Authors PMID Year
1
Expression of LIGHT/TNFSF14 and Its Receptors, HVEM and LTβR, Correlates with the Severity of Fibrosis in Lacrimal Sacs from Patients with Lacrimal Duct Obstruction. 61
33188486 2021
2
[Lacrimal Duct Obstruction in Adults]. 61
33207380 2021
3
Biallelic CDK9 variants as a cause of a new multiple-malformation syndrome with retinal dystrophy mimicking the CHARGE syndrome. 61
33640901 2021
4
Automatic screening of tear meniscus from lacrimal duct obstructions using anterior segment optical coherence tomography images by deep learning. 61
33576859 2021
5
Lacrimal Duct Obstruction Caused by Nasomaxillary Fracture: A Retrospective Analysis of Consecutive 12 Patients by Computed Tomographic Dacryocystography. 61
33427771 2021
6
Transcanalicular endoscopic dacryoplasty in patients with primary acquired nasolacrimal duct obstruction. 61
32743774 2021
7
Cardiac sarcoidosis as an incidental finding: A case report. 61
32980628 2020
8
Evaluation of Lacrimal Drainage Function in the Anophthalmic Socket by Dacryoscintigraphy. 61
32796299 2020
9
Ophthalmological outcomes of unilateral coronal synostosis in young children. 61
32753041 2020
10
[Functional nasolacrimal duct decompression for chronic dacryocystitis]. 61
32791645 2020
11
[Lacrimal Stenosis after Chemical and Thermal Ocular Burns]. 61
30939624 2019
12
An Unusual Case of Lacrimal Duct Obstruction in a Teenager. 61
30789663 2019
13
[Transcanalicular endoscopy of the lacrimal pathways]. 61
31573560 2019
14
[Secondary acquired lacrimal duct obstruction and cervical lymphadenopathy]. 61
29460016 2018
15
Pathological changes of the nasolacrimal duct in rabbit models of chronic dacryocystitis: correlation with lacrimal endoscopic findings. 61
30187128 2018
16
The relationship between topical anti-glaucoma medications and the development of lacrimal drainage system obstruction. 61
30304090 2018
17
[A model of ophthalmological network care including primary care centers and a tertiary care hospital]. 61
30534867 2018
18
[Foreign body obstruction in the lacrimal duct after exploration of the duct]. 61
30152326 2018
19
[Recognition and prevention of problems in lacrimal duct surgery]. 61
29761204 2018
20
An insertion mutation in HOXC13 underlies pure hair and nail ectodermal dysplasia with lacrimal duct obstruction. 61
29278420 2018
21
Prevalence and Risk Factors of Amblyopia among Refractive Errors in an Eastern European Population. 61
30344237 2018
22
The role of "after washing imaging" in evaluation of tear drainage system by dacryoscintigraphy. 61
29956816 2018
23
[Exophthalmometry with computed tomography]. 61
29771884 2018
24
Learning Curve in External DCR - A Trainee's Perspective. 61
29634700 2017
25
Causes of dacryocystorhinostomy failure: External versus endoscopic approach. 61
28490404 2017
26
Factors Associated With the Efficacy of Probing for Adult Patients With Lacrimal Duct Obstruction. 61
27015237 2017
27
KCNK9 Imprinting Syndrome 61
28333430 2017
28
[The radiologic study of the nasolacrimal duct decompression surgery for treatment of chronic]. 61
29871244 2017
29
Intervention using a novel biodegradable hollow stent containing polylactic acid-polyprolactone-polyethylene glycol complexes against lacrimal duct obstruction disease. 61
28570687 2017
30
Cytokine Profiles of Tear Fluid From Patients With Pediatric Lacrimal Duct Obstruction. 61
28114586 2017
31
Risk factors for aerobic bacterial conjunctival flora in preoperative cataract patients. 61
27419840 2016
32
[The treatment of nose-eye correlated diseases with external nasal incision combined with nasal cavity approach surgery through endoscope]. 61
29798331 2016
33
[Rosenmüller valve during endoscopic dacryocystorhinostomy in treating refractory nasolacrimal duct obstruction]. 61
27480301 2016
34
[A Retrospective Analysis of Epiphora Due to Docetaxel]. 61
27306811 2016
35
High-resolution dacryoendoscopy for observation for pediatric lacrimal duct obstruction. 61
29503884 2016
36
[A comparative study of lacrimal magnetic resonance hydrography and lacrimal endoscopy examination in the diagnosis and treatment of lacrimal duct obstructive diseases]. 61
26906707 2016
37
[Comparing of Treatment Results of Monocanalicular and Bicanalicular Intubation in Inborn Lacrimal Duct Obstruction]. 61
28224803 2016
38
Lacrimal Duct Occlusion Is Associated with Infectious Keratitis. 61
27766030 2016
39
[Erratum to: Treatment of congenital lacrimal duct obstruction : A prospective clinical cohort study]. 61
26577890 2015
40
[Treatment of congenital lacrimal duct obstruction: A prospective clinical cohort study]. 61
26070835 2015
41
Bilateral congenital lacrimal fistulas in an adult as part of ectrodactyly-ectodermal dysplasia-clefting syndrome: A rare anomaly. 61
26655010 2015
42
Pathology of the lower nasolacrimal duct mucosa at multiple time points after lacrimal retrograde catheterization in rabbit. 61
26214474 2015
43
[A case of lacrimal duct obstruction caused by capecitabine]. 61
25596694 2015
44
Long-term tear volume changes after blepharoptosis surgery and blepharoplasty. 61
25425312 2014
45
Bacterial spectrum and antimicrobial susceptibility patterns in acquired and connatal lacrimal duct stenosis. 61
24912091 2014
46
Endonasal nasolacrimal duct surgery: a comparative study of two techniques. 61
24190758 2014
47
[Case of lacrimal duct obstruction]. 61
25112109 2014
48
Epiphora in lung cancer patients receiving docetaxel: a case series. 61
24886618 2014
49
Relationship between frequent swimming pool use and lacrimal duct obstruction. 61
24112783 2014
50
Short-term changes in tear volume after blepharoptosis repair. 61
24212766 2014

Variations for Lacrimal Duct Obstruction

Expression for Lacrimal Duct Obstruction

Search GEO for disease gene expression data for Lacrimal Duct Obstruction.

Pathways for Lacrimal Duct Obstruction

GO Terms for Lacrimal Duct Obstruction

Biological processes related to Lacrimal Duct Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-strand break repair GO:0006302 9.16 EYA1 DDX1
2 anatomical structure development GO:0048856 8.96 TFAP2A EYA1
3 inner ear morphogenesis GO:0042472 8.62 TFAP2A EYA1

Sources for Lacrimal Duct Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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