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MCID: LCR001
MIFTS: 33

Lacrimal Duct Obstruction

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Lacrimal Duct Obstruction

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MalaCards integrated aliases for Lacrimal Duct Obstruction:

Name: Lacrimal Duct Obstruction 12 45 15
Obstruction of Lacrimal Canaliculus 12
Obstruction of Lacrimal Ducts 12
Blocked Lacrimal Canaliculus 12

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13929
MeSH 45 D007767
NCIt 51 C34757
SNOMED-CT 69 95769009
UMLS 74 C0022906
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Summaries for Lacrimal Duct Obstruction

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MalaCards based summary : Lacrimal Duct Obstruction, also known as obstruction of lacrimal canaliculus, is related to branchiooculofacial syndrome and chronic dacryocystitis. An important gene associated with Lacrimal Duct Obstruction is DCXR (Dicarbonyl And L-Xylulose Reductase), and among its related pathways/superpathways is Hypothetical Craniofacial Development Pathway. The drugs Tetracaine and Ephedrine have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are behavior/neurological and endocrine/exocrine gland

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Related Diseases for Lacrimal Duct Obstruction

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Diseases related to Lacrimal Duct Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 branchiooculofacial syndrome 31.9 EYA1 SIX5 TFAP2A
2 chronic dacryocystitis 29.9 DCXR PGRMC1
3 growth retardation, deafness, femoral epiphyseal dysplasia, and lacrimal duct obstruction 12.4
4 blepharonasofacial malformation syndrome 11.5
5 lacrimal duct defect 11.4
6 deafness, epiphyseal dysplasia, short stature 11.4
7 branchiootorenal syndrome 1 10.1 EYA1 SIX1
8 deafness, autosomal dominant 23 10.1 EYA1 SIX1
9 ear malformation 10.0 EYA1 TFAP2A
10 ectodermal dysplasia 4, hair/nail type 10.0
11 ectodermal dysplasia 10.0
12 dacryoadenitis 10.0
13 dacryocystitis 10.0
14 eaf 10.0
15 chronic inflammation of lacrimal passage 9.9 DCXR PGRMC1
16 deafness, autosomal dominant 10 9.9 EYA1 SIX1 SIX5
17 branchiootic syndrome 9.9 EYA1 SIX1 SIX5
18 branchiootorenal syndrome 9.9 EYA1 SIX1 SIX5
19 renal hypodysplasia/aplasia 1 9.9 EYA1 SIX5

Graphical network of the top 20 diseases related to Lacrimal Duct Obstruction:



Diseases related to Lacrimal Duct Obstruction
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Symptoms & Phenotypes for Lacrimal Duct Obstruction

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MGI Mouse Phenotypes related to Lacrimal Duct Obstruction:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 EYA1 HOXC13 PGRMC1 SIX1 TFAP2A TGFB1
2 endocrine/exocrine gland MP:0005379 9.95 EYA1 PGRMC1 SIX1 SIX5 TFAP2A TGFB1
3 craniofacial MP:0005382 9.93 EYA1 HOXC13 SIX1 TFAP2A TGFB1 TP63
4 digestive/alimentary MP:0005381 9.91 EYA1 HOXC13 SIX1 TFAP2A TGFB1 TP63
5 reproductive system MP:0005389 9.8 EYA1 PGRMC1 PRSS21 SIX5 TGFB1 TP63
6 muscle MP:0005369 9.77 EYA1 SIX1 SIX5 TGFB1 TP63
7 respiratory system MP:0005388 9.65 EYA1 SIX1 TFAP2A TGFB1 TP63
8 skeleton MP:0005390 9.63 EYA1 HOXC13 SIX1 TFAP2A TGFB1 TP63
9 vision/eye MP:0005391 9.17 EYA1 HOXC13 SIX1 SIX5 TFAP2A TGFB1
10 taste/olfaction MP:0005394 9.13 PGRMC1 SIX1 TP63
Sources

Drugs & Therapeutics for Lacrimal Duct Obstruction

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Drugs for Lacrimal Duct Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tetracaine Approved, Vet_approved Phase 1, Phase 2 94-24-6 5411
2
Ephedrine Approved Phase 1, Phase 2 299-42-3 9294
3
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
4
Pseudoephedrine Approved Phase 1, Phase 2 90-82-4 7028
5 Anesthetics Phase 1, Phase 2
6 Mitomycins Not Applicable
7 Ether Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Comparative Study of Two Endoscopic Operations for Lacrimal Duct Obstruction Completed NCT02636257 Phase 1, Phase 2
2 Analysis of 86 Dacryoliths at the University Hospital Ostrava Completed NCT01826734
3 Risk and Importance of Peroperative Nasal Hemorrhage in the Treatment of Lacrimal Duct Obstruction in Young Children Recruiting NCT02851641
4 Endoscopic Dacryocystorhinostomy Prospective Research Active, not recruiting NCT00571129 Not Applicable
5 Long Term Effectiveness of Dacryocystorinostomy With and Without Bicanalicular Intubation Not yet recruiting NCT03960996 Not Applicable
6 A Feasibility Study to Develop a Protocol for Functional Lacrimal Magnetic Resonance Imaging Not yet recruiting NCT03411889 Not Applicable

Search NIH Clinical Center for Lacrimal Duct Obstruction

Cochrane evidence based reviews: lacrimal duct obstruction

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Genetic Tests for Lacrimal Duct Obstruction

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Anatomical Context for Lacrimal Duct Obstruction

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MalaCards organs/tissues related to Lacrimal Duct Obstruction:

42
Eye
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Publications for Lacrimal Duct Obstruction

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Articles related to Lacrimal Duct Obstruction:

(show all 18)
# Title Authors Year
1
An Unusual Case of Lacrimal Duct Obstruction in a Teenager. ( 30789663 )
2019
2
An insertion mutation in HOXC13 underlies pure hair and nail ectodermal dysplasia with lacrimal duct obstruction. ( 29278420 )
2018
3
Factors Associated With the Efficacy of Probing for Adult Patients With Lacrimal Duct Obstruction. ( 27015237 )
2017
4
Cytokine Profiles of Tear Fluid From Patients With Pediatric Lacrimal Duct Obstruction. ( 28114586 )
2017
5
Intervention using a novel biodegradable hollow stent containing polylactic acid-polyprolactone-polyethylene glycol complexes against lacrimal duct obstruction disease. ( 28570687 )
2017
6
High-resolution dacryoendoscopy for observation for pediatric lacrimal duct obstruction. ( 29503884 )
2016
7
Relationship between frequent swimming pool use and lacrimal duct obstruction. ( 24112783 )
2014
8
Direct endoscopic probing for congenital lacrimal duct obstruction. ( 23566023 )
2013
9
Transcanalicular approach to adult lacrimal duct obstruction: a review of instruments and methods. ( 19320304 )
2009
10
Uncommon presentation of congenital lacrimal duct obstruction a case report of congenital amniontocele. ( 22400096 )
2007
11
Eosinophilic angiocentric fibrosis: an unusual entity producing complete lacrimal duct obstruction. ( 16754230 )
2006
12
The clinical value of dacryoscintigraphy in the selection of surgical approach for patients with functional lacrimal duct obstruction. ( 16248384 )
2005
13
Diagnostic Ophthalmology. Left dacryocystitis with naso-lacrimal duct obstruction. ( 15600163 )
2004
14
Dilatation and stenting for naso-lacrimal duct obstruction: a pilot project. ( 10551300 )
1999
15
Bacteriology of lacrimal duct obstruction in adults. ( 9135406 )
1997
16
Silicone intubation for the treatment of congenital lacrimal duct obstruction: successful results removing the tubes after six weeks. ( 3211482 )
1988
17
CORTICOSTEROIDS AND FIBROLYSIN IN THE PREVENTION OF LACRIMAL DUCT OBSTRUCTION. ( 18170750 )
1962
18
The management of lacrimal duct obstruction. ( 14824621 )
1951
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Variations for Lacrimal Duct Obstruction

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Expression for Lacrimal Duct Obstruction

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Search GEO for disease gene expression data for Lacrimal Duct Obstruction.
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Pathways for Lacrimal Duct Obstruction

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Pathways related to Lacrimal Duct Obstruction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Hypothetical Craniofacial Development Pathway 1
9.53 TFAP2A TP63
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GO Terms for Lacrimal Duct Obstruction

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Cellular components related to Lacrimal Duct Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microvillus GO:0005902 8.62 DCXR TGFB1

Biological processes related to Lacrimal Duct Obstruction according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.96 EYA1 HOXC13 SIX1 SIX5 TP63
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.92 SIX1 TFAP2A TGFB1 TP63
3 positive regulation of transcription, DNA-templated GO:0045893 9.8 EYA1 SIX1 TFAP2A TGFB1 TP63
4 negative regulation of transcription, DNA-templated GO:0045892 9.72 SIX1 SIX5 TFAP2A TGFB1 TP63
5 sensory perception of sound GO:0007605 9.69 EYA1 SIX1 TFAP2A
6 positive regulation of epithelial cell proliferation GO:0050679 9.64 EYA1 TGFB1
7 embryonic skeletal system morphogenesis GO:0048704 9.64 EYA1 SIX1
8 inner ear development GO:0048839 9.63 SIX1 TGFB1
9 outflow tract morphogenesis GO:0003151 9.63 EYA1 SIX1
10 branching involved in ureteric bud morphogenesis GO:0001658 9.61 EYA1 SIX1
11 hair follicle development GO:0001942 9.61 HOXC13 TP63
12 pattern specification process GO:0007389 9.61 EYA1 SIX1 TP63
13 embryonic cranial skeleton morphogenesis GO:0048701 9.6 SIX1 TFAP2A
14 positive regulation of bone mineralization GO:0030501 9.59 TFAP2A TGFB1
15 embryonic forelimb morphogenesis GO:0035115 9.58 TFAP2A TP63
16 regulation of neuron differentiation GO:0045664 9.58 EYA1 SIX1
17 cochlea morphogenesis GO:0090103 9.57 EYA1 SIX1
18 middle ear morphogenesis GO:0042474 9.55 EYA1 SIX1
19 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.54 SIX1 TGFB1
20 inner ear morphogenesis GO:0042472 9.54 EYA1 SIX1 TFAP2A
21 pharyngeal system development GO:0060037 9.52 EYA1 SIX1
22 neuron fate specification GO:0048665 9.49 EYA1 SIX1
23 aorta morphogenesis GO:0035909 9.48 EYA1 SIX1
24 otic vesicle development GO:0071599 9.46 EYA1 SIX1
25 ureteric bud development GO:0001657 9.33 EYA1 SIX1 TGFB1
26 positive regulation of secondary heart field cardioblast proliferation GO:0072513 9.26 EYA1 SIX1
27 positive regulation of transcription by RNA polymerase II GO:0045944 9.17 EYA1 HOXC13 SIX1 SIX5 TFAP2A TGFB1
28 anatomical structure development GO:0048856 9.13 EYA1 SIX1 SIX5
29 regulation of transcription, DNA-templated GO:0006355 10.02 HOXC13 SIX1 SIX5 TFAP2A TP63

Molecular functions related to Lacrimal Duct Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.72 HOXC13 SIX1 SIX5 TFAP2A TP63
2 chromatin binding GO:0003682 9.46 HOXC13 SIX1 TFAP2A TP63
3 transcription regulatory region DNA binding GO:0044212 9.43 SIX1 TFAP2A TP63
4 transcription regulatory region sequence-specific DNA binding GO:0000976 9.13 SIX1 SIX5 TFAP2A
5 sequence-specific DNA binding GO:0043565 9.02 HOXC13 SIX1 SIX5 TFAP2A TP63
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Sources for Lacrimal Duct Obstruction

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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