MCID: LCR001
MIFTS: 28

Lacrimal Duct Obstruction

Categories: Neuronal diseases
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Aliases & Classifications for Lacrimal Duct Obstruction

MalaCards integrated aliases for Lacrimal Duct Obstruction:

Name: Lacrimal Duct Obstruction 11 5 43 14
Obstruction of Lacrimal Canaliculus 11
Obstruction of Lacrimal Ducts 11
Blocked Lacrimal Canaliculus 11

Classifications:



External Ids:

Disease Ontology 11 DOID:13929
MeSH 43 D007767
NCIt 49 C34757
SNOMED-CT 68 95769009
UMLS 71 C0022906

Summaries for Lacrimal Duct Obstruction

MalaCards based summary: Lacrimal Duct Obstruction, also known as obstruction of lacrimal canaliculus, is related to branchiooculofacial syndrome and growth retardation, deafness, femoral epiphyseal dysplasia, and lacrimal duct obstruction. An important gene associated with Lacrimal Duct Obstruction is HOXC13 (Homeobox C13), and among its related pathways/superpathways is Hypothetical craniofacial development pathway. The drugs Silicon and Lactitol have been mentioned in the context of this disorder. Affiliated tissues include eye, tongue and pituitary, and related phenotype is vision/eye.

Related Diseases for Lacrimal Duct Obstruction

Diseases related to Lacrimal Duct Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 branchiooculofacial syndrome 31.8 TFAP2A EYA1
2 growth retardation, deafness, femoral epiphyseal dysplasia, and lacrimal duct obstruction 11.5
3 lacrimal duct defect 11.5
4 blepharonasofacial malformation syndrome 11.4
5 hypertelorism, preauricular sinus, punctal pits, and deafness 11.2
6 excessive tearing 10.6
7 dacryocystitis 10.5
8 chronic dacryocystitis 10.2
9 orofacial cleft 1 10.1 TFAP2A EYA1
10 branchiootorenal syndrome 1 10.1 TFAP2A EYA1
11 patulous eustachian tube 10.1 SIX5 EYA1
12 eustachian tube disease 10.1 SIX5 EYA1
13 cranioectodermal dysplasia 2 10.1 WDR27 SMIM23
14 deafness, autosomal dominant 10 10.1 SIX5 EYA1
15 congenital anomalies of kidney and urinary tract 2 10.0 SIX5 EYA1
16 renal hypoplasia 10.0 SIX5 EYA1
17 waardenburg syndrome, type 1 10.0 SMIM23 EYA1
18 papillorenal syndrome 10.0 SIX5 EYA1
19 down syndrome 10.0
20 spastic ataxia, charlevoix-saguenay type 10.0
21 ectodermal dysplasia 4, hair/nail type 10.0
22 acute dacryocystitis 10.0
23 phlegmonous dacryocystitis 10.0
24 ectodermal dysplasia 10.0
25 conjunctivitis 10.0
26 purulent endophthalmitis 10.0
27 dacryocystocele 10.0
28 cytokine deficiency 10.0
29 eaf 10.0
30 nasolacrimal duct cyst 10.0
31 branchiootic syndrome 10.0 SIX5 EYA1
32 branchiootorenal syndrome 10.0 TFAP2A SIX5 EYA1
33 townes-brocks syndrome 9.9 SIX5 EYA1
34 van der woude syndrome 9.8 TP63 TFAP2A
35 orofacial cleft 9.8 TP63 TFAP2A SMIM23 EYA1

Graphical network of the top 20 diseases related to Lacrimal Duct Obstruction:



Diseases related to Lacrimal Duct Obstruction

Symptoms & Phenotypes for Lacrimal Duct Obstruction

MGI Mouse Phenotypes related to Lacrimal Duct Obstruction:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.17 EYA1 HOXC13 RGPD3 SEC14L5 SIX5 TFAP2A

Drugs & Therapeutics for Lacrimal Duct Obstruction

Drugs for Lacrimal Duct Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Silicon Approved, Investigational Phase 2, Phase 3 7440-21-3 4082203
2
Lactitol Approved, Investigational Phase 3 585-86-4 157355
3
Tobramycin Approved, Investigational Phase 3 32986-56-4 36294
4 Anti-Bacterial Agents Phase 3
5 Antibiotics, Antitubercular Phase 3
6 Ophthalmic Solutions Phase 3
7
Racephedrine Approved, Experimental Phase 1, Phase 2 299-42-3, 90-82-4, 90-81-3 5032 9294 7028
8
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
9
Tetracaine Approved, Vet_approved Phase 1, Phase 2 94-24-6 5411
10
Besifloxacin Approved Phase 1 141388-76-3 22743624 10178705
11
Polymyxin B Approved, Vet_approved Phase 1 1405-20-5, 1404-26-8 4868
12
Levoleucovorin Approved, Experimental, Investigational Phase 1 68538-85-2, 58-05-9, 73951-54-9 149436 6006
13
Trimethoprim Approved, Vet_approved Phase 1 738-70-5 5578
14
Folic acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
15 Folic Acid Antagonists Phase 1
16 Folate Phase 1
17 Vitamin B9 Phase 1
18 Anti-Infective Agents Phase 1
19 Antiprotozoal Agents Phase 1
20 Antiparasitic Agents Phase 1
21 Fluoroquinolones Phase 1
22 Vitamin B Complex Phase 1
23 Antimalarials Phase 1
24 Polymyxins Phase 1
25 Pharmaceutical Solutions Phase 1
26 Cytochrome P-450 Enzyme Inhibitors Phase 1
27
Mitomycin Approved 50-07-7 5746
28
Racepinephrine Approved, Vet_approved 51-43-4, 329-65-7 838 5816
29
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
30
Atracurium Approved, Experimental, Investigational 64228-79-1 47319
31
Acetaminophen Approved 103-90-2 1983
32
Nitroglycerin Approved, Investigational 55-63-0 4510
33
Sevoflurane Approved, Vet_approved 28523-86-6 5206
34
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
35
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
36
Tannic acid Approved 1401-55-4 16129878 16129778
37
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
38
Diethyl ether Experimental 60-29-7 3283
39 Alkylating Agents
40 Anesthetics
41 Analgesics
42 Neurotransmitter Agents
43 Antipyretics
44 Neuromuscular Nondepolarizing Agents
45 Neuromuscular Blocking Agents
46 Epinephryl borate
47 Antihypertensive Agents
48 Vasodilator Agents
49 Anesthetics, Local
50 Platelet Aggregation Inhibitors

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 A Randomised Controlled Trial to Compare Success and Complication Rates in Endonasal Dacryocystorhinostomy Surgery With and Without Silicone Tubes Completed NCT00784992 Phase 4
2 Recanalization of Congenital Nasolacrimal Duct Obstruction by Endodiathermy Probe and Intubation Versus Intubation Only Unknown status NCT04148170 Phase 2, Phase 3
3 A Randomized Trial Comparing Immediate Probing in an Office Setting With Deferred Probing in a Facility Setting for Treatment of Nasolacrimal Duct Obstruction in Children 6 to <10 Months Old Completed NCT00780741 Phase 3
4 Euphrasia Eye Drops in Preterm Infants With First Signs of Congestion of Nasolacrimal Duct - a Randomized Double-blind Controlled Trial Completed NCT04122300 Phase 3 Euphrasia Officinalis Preparation;Placebo
5 Monocanalicular Versus Bicanalicular Intubation in the Treatment of Congenital Nasolacrimal Duct Obstruction Completed NCT01233596 Phase 3
6 A Comparative Study of Recessive Spherical Headed Silicone Intubation and Dacryocystorhinostomy Under Nasal Endoscopy in the Treatment of Nasolacrimal Duct Obstruction Completed NCT02636257 Phase 1, Phase 2
7 A Prospective, Double-Blinded, Parallel-Group, Randomized Study to Assess the Safety and Efficacy of Besivance™ for Treatment of Congenital Nasolacrimal Duct Obstruction in Children Completed NCT01431170 Phase 1 Besivance Treatment Group;Polytrim Treatment Group
8 Recovery After Endoscopic Dacryocystorhinostomy Unknown status NCT00571129
9 Self-retaining Bicanalicular Intubation Stent Versus Bicanalicular Silicone Tube for Management of Canalicular Obstruction Unknown status NCT04706117
10 Endoscopy Assisted Probing Versus Simple Probing in Patients With Primary Congenital Nasolacrimal Duct Obstruction: A Randomized Clinical Trial Unknown status NCT03242681
11 To Estimate Whether Corneal Epithelial Defects Occur in Patients With Acquired Nasolacrimal Duct Obstructions is Linked to Changes Occurring Within Ocular Bacterial Flora in These Patients, and What Are the Specific Changes in Their Flora. Unknown status NCT02234700
12 Risk and Importance of Peroperative Nasal Hemorrhage in the Treatment of Lacrimal Duct Obstruction in Young Children Completed NCT02851641
13 Retrospective Data Analysis of Patients Undergoing Lacrimal Drainage System Interventions at The Department of Ophthalmology and Optometry During The Years 2013 - 2017 Completed NCT04931186
14 A Study to Develop a Protocol for Functional Magnetic Resonance Imaging of the Lacrimal Drainage System Completed NCT03411889
15 Long Term Effectiveness of Dacryocystorinostomy With and Without Bicanalicular Intubation Completed NCT03960996
16 Lacrimal Sac Dacryoliths (86 Samples): Chemical and Mineralogic Analyses Completed NCT01826734
17 Case Control Study of the Factors That Affected the Outcome of Treatment of Congenital Nasolacrimal Duct Obstruction Completed NCT02081781
18 External Dacryocystorhinostomy Versus Canalicular Silicone Intubation With Mitomycin C in Primary Acquired Nasolacrimal Duct Obstruction Completed NCT03780868
19 Effect of Counseling and Reminders in Improving the Follow-up Rate of Pediatric Patients (0-16 Years) at Bharatpur Eye Hospital, Nepal: an Intervention Study Completed NCT04837534
20 A Prospective Study of Surgical Procedures for the Treatment of Persistent Nasolacrimal Duct Obstruction in Children Less Than Four Years Old Completed NCT00315315
21 A Prospective Study of Primary Surgical Treatment of Nasolacrimal Duct Obstruction in Children Less Than Four Years Old Completed NCT00315289
22 Lacrimal Drainage Resistance Study Completed NCT01766232
23 Multi-center Clinical Study of Low Temperature Plasma Ablation Combined With Lacrimal Duct Catheterization in the Treatment of Lacrimal Duct Obstructive Diseases Recruiting NCT04943055
24 Safety and Efficacy of the Slit Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction Recruiting NCT03705000
25 Comparison of Local Anesthesia and Induced Hypotensive Anesthesia on Quality of External Dacryocystorhinostomy Operation Under General Anesthesia Not yet recruiting NCT05241054 Bupivacaine;Nitroglycerine;Propofol;Fentanyl;Atracurium Besylate;Sevoflurane;Lactated Ringers;Paracetamol

Search NIH Clinical Center for Lacrimal Duct Obstruction

Cochrane evidence based reviews: lacrimal duct obstruction

Genetic Tests for Lacrimal Duct Obstruction

Anatomical Context for Lacrimal Duct Obstruction

Organs/tissues related to Lacrimal Duct Obstruction:

MalaCards : Eye, Tongue, Pituitary, Thyroid, Breast, Lung, Bone

Publications for Lacrimal Duct Obstruction

Articles related to Lacrimal Duct Obstruction:

(show top 50) (show all 152)
# Title Authors PMID Year
1
Commentary: Rule out lacrimal duct obstruction before every intraocular procedure. 62
36308106 2022
2
[Effect of endonasal endoscopic dacryocystorhinostomy combined with lacrimal duct drainage tube implantation in treating lacrimal duct obstruction]. 62
36347577 2022
3
Ocular manifestations of ANCA-associated vasculitis. 62
36440847 2022
4
Dacryoendoscopic findings in the failed silicone tube intubations without dacryoendoscopy. 62
36220637 2022
5
Rhinological Status of Patients with Nasolacrimal Duct Obstruction. 62
35846831 2022
6
Familial cleft tongue caused by a unique translation initiation codon variant in TP63. 62
34629465 2022
7
Analysis of Lacrimal Duct Morphology from Cone-Beam Computed Tomography Dacryocystography in a Japanese Population. 62
35770249 2022
8
Lacrimal Duct Obstruction and Infection Associated with Non-Traumatic Corneal Perforation: A Case Series. 62
35769810 2022
9
Impact of habitual swimming on the success of lacrimal surgery. 62
34357441 2021
10
Biallelic CDK9 variants as a cause of a new multiple-malformation syndrome with retinal dystrophy mimicking the CHARGE syndrome. 62
33640901 2021
11
[The effect of endoscopic dacryocystorhinostomy on different lacrimal duct obstruction]. 62
34304525 2021
12
Detection & analysis of inflammatory cytokines in tears of patients with lacrimal duct obstruction. 62
35662094 2021
13
Automatic screening of tear meniscus from lacrimal duct obstructions using anterior segment optical coherence tomography images by deep learning. 62
33576859 2021
14
Application of a symptoms score questionnaire after conjunctivodacryocystorhinostomy: outcomes. 62
34264918 2021
15
Lacrimal Duct Obstruction Caused by Nasomaxillary Fracture: A Retrospective Analysis of Consecutive 12 Patients by Computed Tomographic Dacryocystography. 62
33427771 2021
16
Expression of LIGHT/TNFSF14 and Its Receptors, HVEM and LTβR, Correlates with the Severity of Fibrosis in Lacrimal Sacs from Patients with Lacrimal Duct Obstruction. 62
33188486 2021
17
[Lacrimal Duct Obstruction in Adults]. 62
33207380 2021
18
Transcanalicular endoscopic dacryoplasty in patients with primary acquired nasolacrimal duct obstruction. 62
32743774 2021
19
Cardiac sarcoidosis as an incidental finding: A case report. 62
32980628 2020
20
Evaluation of Lacrimal Drainage Function in the Anophthalmic Socket by Dacryoscintigraphy. 62
32796299 2020
21
Ophthalmological outcomes of unilateral coronal synostosis in young children. 62
32753041 2020
22
[Functional nasolacrimal duct decompression for chronic dacryocystitis]. 62
32791645 2020
23
[Lacrimal Stenosis after Chemical and Thermal Ocular Burns]. 62
30939624 2019
24
An Unusual Case of Lacrimal Duct Obstruction in a Teenager. 62
30789663 2019
25
[Transcanalicular endoscopy of the lacrimal pathways]. 62
31573560 2019
26
[Secondary acquired lacrimal duct obstruction and cervical lymphadenopathy]. 62
29460016 2018
27
The relationship between topical anti-glaucoma medications and the development of lacrimal drainage system obstruction. 62
30304090 2018
28
Pathological changes of the nasolacrimal duct in rabbit models of chronic dacryocystitis: correlation with lacrimal endoscopic findings. 62
30187128 2018
29
[A model of ophthalmological network care including primary care centers and a tertiary care hospital]. 62
30534867 2018
30
[Foreign body obstruction in the lacrimal duct after exploration of the duct]. 62
30152326 2018
31
[Recognition and prevention of problems in lacrimal duct surgery]. 62
29761204 2018
32
An insertion mutation in HOXC13 underlies pure hair and nail ectodermal dysplasia with lacrimal duct obstruction. 62
29278420 2018
33
Prevalence and Risk Factors of Amblyopia among Refractive Errors in an Eastern European Population. 62
30344237 2018
34
[Exophthalmometry with computed tomography]. 62
29771884 2018
35
The role of "after washing imaging" in evaluation of tear drainage system by dacryoscintigraphy. 62
29956816 2018
36
Learning Curve in External DCR - A Trainee's Perspective. 62
29634700 2017
37
Causes of dacryocystorhinostomy failure: External versus endoscopic approach. 62
28490404 2017
38
Factors Associated With the Efficacy of Probing for Adult Patients With Lacrimal Duct Obstruction. 62
27015237 2017
39
KCNK9 Imprinting Syndrome 62
28333430 2017
40
[The radiologic study of the nasolacrimal duct decompression surgery for treatment of chronic]. 62
29871244 2017
41
Intervention using a novel biodegradable hollow stent containing polylactic acid-polyprolactone-polyethylene glycol complexes against lacrimal duct obstruction disease. 62
28570687 2017
42
Cytokine Profiles of Tear Fluid From Patients With Pediatric Lacrimal Duct Obstruction. 62
28114586 2017
43
Risk factors for aerobic bacterial conjunctival flora in preoperative cataract patients. 62
27419840 2016
44
[The treatment of nose-eye correlated diseases with external nasal incision combined with nasal cavity approach surgery through endoscope]. 62
29798331 2016
45
[Rosenmüller valve during endoscopic dacryocystorhinostomy in treating refractory nasolacrimal duct obstruction]. 62
27480301 2016
46
[A Retrospective Analysis of Epiphora Due to Docetaxel]. 62
27306811 2016
47
High-resolution dacryoendoscopy for observation for pediatric lacrimal duct obstruction. 62
29503884 2016
48
[A comparative study of lacrimal magnetic resonance hydrography and lacrimal endoscopy examination in the diagnosis and treatment of lacrimal duct obstructive diseases]. 62
26906707 2016
49
Lacrimal Duct Occlusion Is Associated with Infectious Keratitis. 62
27766030 2016
50
[Comparing of Treatment Results of Monocanalicular and Bicanalicular Intubation in Inborn Lacrimal Duct Obstruction]. 62
28224803 2016

Variations for Lacrimal Duct Obstruction

Expression for Lacrimal Duct Obstruction

Search GEO for disease gene expression data for Lacrimal Duct Obstruction.

Pathways for Lacrimal Duct Obstruction

Pathways related to Lacrimal Duct Obstruction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
9.58 TP63 TFAP2A

GO Terms for Lacrimal Duct Obstruction

Sources for Lacrimal Duct Obstruction

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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