Lacrimal Gland Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lacrimal Gland Adenocarcinoma

MalaCards integrated aliases for Lacrimal Gland Adenocarcinoma:

Name: Lacrimal Gland Adenocarcinoma ¹² ¹⁵

Adenocarcinoma of Lacrimal Gland ¹² ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases Eye diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:298

NCIt ⁵⁰ C4541

SNOMED-CT ⁶⁸ 254988008

UMLS ⁷³ C0346341

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Summaries for Lacrimal Gland Adenocarcinoma

Disease Ontology : ¹² A lacrimal gland carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Lacrimal Gland Adenocarcinoma, also known as adenocarcinoma of lacrimal gland, is related to lacrimal gland adenoid cystic carcinoma and lacrimal system cancer. An important gene associated with Lacrimal Gland Adenocarcinoma is BPTF (Bromodomain PHD Finger Transcription Factor), and among its related pathways/superpathways are MicroRNAs in cancer and Glucose / Energy Metabolism. Affiliated tissues include eye, and related phenotypes are mortality/aging and integument

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Related Diseases for Lacrimal Gland Adenocarcinoma

Diseases related to Lacrimal Gland Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)

#	Related Disease	Score	Top Affiliating Genes
1	lacrimal gland adenoid cystic carcinoma	10.8	BPTF NOTCH2
2	lacrimal system cancer	10.7	BPTF NFIB PSPH
3	lacrimal gland carcinoma	10.7	BPTF NFIB PSPH
4	sigmoid neoplasm	10.6	HRAS KRAS
5	apocrine adenoma	10.6	HRAS KRAS
6	schimmelpenning-feuerstein-mims syndrome	10.6	HRAS KRAS
7	periampullary adenoma	10.5	HRAS KRAS
8	paronychia	10.5	HRAS KRAS
9	cutaneous adenocystic carcinoma	10.4	MYBL1 NFIB
10	lung adenoid cystic carcinoma	10.4	HRAS KRAS NFIB
11	bile duct cysts	10.4	HRAS KRAS
12	aggressive digital papillary adenocarcinoma	10.3	HRAS KRAS
13	core binding factor acute myeloid leukemia	10.3	ABCG2 HRAS KRAS
14	secondary hypertrophic osteoarthropathy	10.3	HRAS KRAS
15	pilocytic astrocytoma	10.3	HRAS KRAS NFIB
16	cell type cancer	10.2	HRAS KRAS PROM1
17	gastrointestinal system cancer	10.2	HRAS KRAS PROM1
18	breast adenoid cystic carcinoma	10.1	MYBL1 NFIB
19	pancreas adenocarcinoma	10.1	HRAS KRAS PROM1
20	adenocarcinoma	10.0
21	adenoid cystic carcinoma	9.9	HRAS KRAS MYBL1 NFIB
22	nasal cavity adenocarcinoma	9.9	HRAS KRAS

Graphical network of the top 20 diseases related to Lacrimal Gland Adenocarcinoma:

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Symptoms & Phenotypes for Lacrimal Gland Adenocarcinoma

MGI Mouse Phenotypes related to Lacrimal Gland Adenocarcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	10.03	BPTF CA9 ENG GLS HRAS KRAS
2	integument	MP:0010771	9.92	ENG HRAS HTATIP2 KRAS MYBL1 NOTCH2
3	digestive/alimentary	MP:0005381	9.91	CA9 ENG HRAS KRAS NFIB NOTCH2
4	neoplasm	MP:0002006	9.63	HRAS HTATIP2 KRAS NOTCH2 PROM1 SHMT1
5	normal	MP:0002873	9.56	ABCG2 ENG GLS HRAS KRAS MYBL1
6	respiratory system	MP:0005388	9.17	ENG GLS HRAS KRAS NFIB NOTCH2

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Drugs & Therapeutics for Lacrimal Gland Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Lacrimal Gland Adenocarcinoma

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Genetic Tests for Lacrimal Gland Adenocarcinoma

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Anatomical Context for Lacrimal Gland Adenocarcinoma

MalaCards organs/tissues related to Lacrimal Gland Adenocarcinoma:

⁴¹

Eye

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Publications for Lacrimal Gland Adenocarcinoma

Articles related to Lacrimal Gland Adenocarcinoma:

#	Title	Authors	Year
1	Surgical excision of a feline orbital lacrimal gland adenocarcinoma with adjunctive cryotherapy and carboplatin-impregnated bead implantation. ( 28799265 )	Dorbandt D.M....Hamor R.E.	2017
2	Primary lacrimal gland adenocarcinoma of the third eyelid in a horse. ( 21199279 )	Mathes R.L....Anthony Moore P.	2011

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Genes for Lacrimal Gland Adenocarcinoma

Genes related to Lacrimal Gland Adenocarcinoma (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	BPTF	Bromodomain PHD Finger Transcription Factor	Protein Coding	15.67	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	PSPH	Phosphoserine Phosphatase	Protein Coding	15.61	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	NFIB	Nuclear Factor I B	Protein Coding	15.1	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	SHMT1	Serine Hydroxymethyltransferase 1	Protein Coding	14.85	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	SDHA	Succinate Dehydrogenase Complex Flavoprotein Subunit A	Protein Coding	14.72	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	GLS	Glutaminase	Protein Coding	14.43	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	NOTCH2	Notch 2	Protein Coding	14.26	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	ENG	Endoglin	Protein Coding	13.69	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	13.57	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	ABCG2	ATP Binding Cassette Subfamily G Member 2 (Junior Blood Group)	Protein Coding	13.54	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	13.4	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	PROM1	Prominin 1	Protein Coding	13.32	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	RPL39L	Ribosomal Protein L39 Like	Protein Coding	6.81	DISEASES inferred ¹⁵
14	RPL39	Ribosomal Protein L39	Protein Coding	6.48	DISEASES inferred ¹⁵
15	MYBL1	MYB Proto-Oncogene Like 1	Protein Coding	5.61	DISEASES inferred ¹⁵
16	HTATIP2	HIV-1 Tat Interactive Protein 2	Protein Coding	5.54	DISEASES inferred ¹⁵
17	BRMS1L	BRMS1 Like Transcriptional Repressor	Protein Coding	5.24	DISEASES inferred ¹⁵
18	SLC1A5	Solute Carrier Family 1 Member 5	Protein Coding	4.79	DISEASES inferred ¹⁵
19	CA9	Carbonic Anhydrase 9	Protein Coding	3.84	DISEASES inferred ¹⁵
20	MAP1LC3A	Microtubule Associated Protein 1 Light Chain 3 Alpha	Protein Coding	3.42	DISEASES inferred ¹⁵

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Variations for Lacrimal Gland Adenocarcinoma

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Expression for Lacrimal Gland Adenocarcinoma

Search GEO for disease gene expression data for Lacrimal Gland Adenocarcinoma.

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Pathways for Lacrimal Gland Adenocarcinoma

Pathways related to Lacrimal Gland Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	MicroRNAs in cancer ³⁷	12.23	GLS HRAS KRAS NOTCH2
2	Glucose / Energy Metabolism ⁴	12.04	ABCG2 CA9 SDHA SHMT1 SLC1A5
3	Thyroid hormone signaling pathway ³⁷	11.72	HRAS KRAS NOTCH2
4	Angiogenesis (CST) ⁴	11.53	CA9 ENG NOTCH2
5	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.44	ABCG2 NOTCH2 PROM1
6	Pathways Affected in Adenoid Cystic Carcinoma ¹	11.32	HRAS MYBL1 NFIB
7	HIF-1-alpha transcription factor network ¹	11.25	ABCG2 CA9 ENG
8	Central carbon metabolism in cancer ³⁷	10.74	GLS HRAS KRAS SLC1A5
9	Extracellular vesicle-mediated signaling in recipient cells ¹	10.61	HRAS KRAS PROM1
10	p38MAPK events ⁶⁶	10.55	HRAS KRAS

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GO Terms for Lacrimal Gland Adenocarcinoma

Biological processes related to Lacrimal Gland Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to isolation stress	GO:0035900	8.96	HRAS KRAS
2	L-serine metabolic process	GO:0006563	8.62	PSPH SHMT1

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