Lacrimal Gland Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lacrimal Gland Adenocarcinoma

MalaCards integrated aliases for Lacrimal Gland Adenocarcinoma:

Name: Lacrimal Gland Adenocarcinoma ¹² ¹⁵

Adenocarcinoma of Lacrimal Gland ¹² ⁷⁴

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Eye diseases Neuronal diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:298

NCIt ⁵¹ C4541

UMLS ⁷⁴ C0346341

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Summaries for Lacrimal Gland Adenocarcinoma

Disease Ontology : ¹² A lacrimal gland carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Lacrimal Gland Adenocarcinoma, also known as adenocarcinoma of lacrimal gland, is related to adenocarcinoma and alacrima, achalasia, and mental retardation syndrome. An important gene associated with Lacrimal Gland Adenocarcinoma is PSPH (Phosphoserine Phosphatase), and among its related pathways/superpathways are One carbon pool by folate and Pyruvate metabolism and Citric Acid (TCA) cycle. Affiliated tissues include eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Lacrimal Gland Adenocarcinoma

Diseases related to Lacrimal Gland Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	adenocarcinoma	10.3
2	alacrima, achalasia, and mental retardation syndrome	9.7	BPTF NFIB
3	lacrimal system cancer	9.3	BPTF NFIB PSPH SHMT1
4	lacrimal gland carcinoma	9.2	BPTF NFIB PSPH SHMT1

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Symptoms & Phenotypes for Lacrimal Gland Adenocarcinoma

GenomeRNAi Phenotypes related to Lacrimal Gland Adenocarcinoma according to GeneCards Suite gene sharing:

²⁷ (show all 13)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	9.47	NFIB
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	9.47	NFIB
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-12	9.47	BPTF
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	9.47	BPTF
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.47	NFIB
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-185	9.47	BPTF
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	9.47	BPTF
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-202	9.47	BPTF
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	9.47	NFIB
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-35	9.47	BPTF NFIB
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-36	9.47	BPTF
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-4	9.47	BPTF
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	9.47	BPTF

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Drugs & Therapeutics for Lacrimal Gland Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Lacrimal Gland Adenocarcinoma

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Genetic Tests for Lacrimal Gland Adenocarcinoma

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Anatomical Context for Lacrimal Gland Adenocarcinoma

MalaCards organs/tissues related to Lacrimal Gland Adenocarcinoma:

⁴²

Eye

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Publications for Lacrimal Gland Adenocarcinoma

Articles related to Lacrimal Gland Adenocarcinoma:

(show all 11)

#	Title	Authors	Year
1	Primary poorly differentiated lacrimal gland adenocarcinoma in left ocular region: A rare case report. ( 30212949 )	Xia F...Ma X	2018
2	Lacrimal gland adenocarcinoma responding to checkpoint inhibition and androgen deprivation. ( 30159157 )	Bulbul A	2018
3	Primary ductal adenocarcinoma of lacrimal gland: Two case reports and review of the literature. ( 29675349 )	Yang HY...Liu CJ	2018
4	Surgical excision of a feline orbital lacrimal gland adenocarcinoma with adjunctive cryotherapy and carboplatin-impregnated bead implantation. ( 28799265 )	Dorbandt D.M....Hamor R.E.	2017
5	A benign presentation of primary ductal adenocarcinoma of lacrimal gland: A rare malignancy. ( 26669339 )	Lau LL...Ahmad SS	2015
6	Clinicopathologic and immunohistochemical features of primary ductal adenocarcinoma of lacrimal gland: five new cases and review of literature. ( 23613093 )	Kubota T...Ichihara S	2013
7	Primary lacrimal gland adenocarcinoma of the third eyelid in a horse. ( 21199279 )	Mathes R.L....Anthony Moore P.	2011
8	Basal cell adenocarcinoma of lacrimal gland. ( 22132848 )	Muduly DK...Samantara S	2011
9	Orbital adenocarcinoma of lacrimal gland origin in a dog. ( 11289213 )	Wang FI...Liu YS	2001
10	Adenocarcinoma of lacrimal gland. ( 8035974 )	Wright JE	1994
11	Adenocarcinoma of lacrimal gland. ( 20256346 )	RUBIN IE	1947

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Genes for Lacrimal Gland Adenocarcinoma

Genes related to Lacrimal Gland Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PSPH	Phosphoserine Phosphatase	Protein Coding	15.39	DISEASES inferred ¹⁵
2	BPTF	Bromodomain PHD Finger Transcription Factor	Protein Coding	15.37	DISEASES inferred ¹⁵
3	NFIB	Nuclear Factor I B	Protein Coding	14.68	DISEASES inferred ¹⁵
4	SHMT1	Serine Hydroxymethyltransferase 1	Protein Coding	14.68	DISEASES inferred ¹⁵
5	SLC16A3	Solute Carrier Family 16 Member 3	Protein Coding	14.49	DISEASES inferred ¹⁵
6	SDHA	Succinate Dehydrogenase Complex Flavoprotein Subunit A	Protein Coding	14.47	DISEASES inferred ¹⁵

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Variations for Lacrimal Gland Adenocarcinoma

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Expression for Lacrimal Gland Adenocarcinoma

Search GEO for disease gene expression data for Lacrimal Gland Adenocarcinoma.

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Pathways for Lacrimal Gland Adenocarcinoma

Pathways related to Lacrimal Gland Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	One carbon pool by folate ³⁸ Show member pathways Antimetabolite Pathway - Folate Cycle, Pharmacodynamics ⁶² dTMP de novo biosynthesis (mitochondrial) ¹ folate transformations I ¹ Methionine metabolism ²³ methionine salvage ¹ Methotrexate Pathway (Cancer Cell), Pharmacodynamics ⁶² One Carbon Metabolism ¹ tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate ¹ Trans-sulfuration and one carbon metabolism ¹	11.41	PSPH SHMT1
2	Pyruvate metabolism and Citric Acid (TCA) cycle ⁶⁷ Show member pathways Citric acid cycle (TCA cycle) ⁶⁷ Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ⁶⁷ NAD phosphorylation and dephosphorylation ¹ Pyruvate metabolism ⁶⁷ Regulation of pyruvate dehydrogenase (PDH) complex ⁶⁷ TCA Cycle ¹	11.27	SDHA SLC16A3
3	Carbon metabolism ³⁸ Show member pathways 2-Oxocarboxylic acid metabolism ³⁸ Biosynthesis of amino acids ³⁸ formaldehyde oxidation ¹	11.12	PSPH SDHA SHMT1
4	Glycine, serine and threonine metabolism ³⁸ Show member pathways glycine betaine degradation ¹ superpathway of choline degradation to L-serine ¹	10.67	PSPH SHMT1

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GO Terms for Lacrimal Gland Adenocarcinoma

Biological processes related to Lacrimal Gland Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	L-serine metabolic process	GO:0006563	8.62	PSPH SHMT1

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