Lacrimal Gland Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lacrimal Gland Adenocarcinoma

MalaCards integrated aliases for Lacrimal Gland Adenocarcinoma:

Name: Lacrimal Gland Adenocarcinoma ¹¹ ¹⁴

Adenocarcinoma of Lacrimal Gland ¹¹ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:298

NCIt ⁴⁹ C4541

SNOMED-CT ⁶⁸ 254988008

UMLS ⁷¹ C0346341

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Summaries for Lacrimal Gland Adenocarcinoma

Disease Ontology: ¹¹ A lacrimal gland carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary: Lacrimal Gland Adenocarcinoma, also known as adenocarcinoma of lacrimal gland, is related to lacrimal gland carcinoma and adenocarcinoma. An important gene associated with Lacrimal Gland Adenocarcinoma is RPL39L (Ribosomal Protein L39 Like), and among its related pathways/superpathways are Regulation of expression of SLITs and ROBOs and Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics.

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Related Diseases for Lacrimal Gland Adenocarcinoma

Diseases related to Lacrimal Gland Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	lacrimal gland carcinoma	26.9	SHMT1 RPL39L RPL39 PSPH NFIB LYPD5
2	adenocarcinoma	10.2
3	ataxia with vitamin e deficiency	10.0
4	conjunctivitis	10.0
5	posttransplant acute limbic encephalitis	10.0
6	rare tumor	10.0
7	serine deficiency	9.6	SHMT1 PSPH
8	lacrimal system cancer	8.7	RPL39L RPL39 PSPH NFIB LYPD5 LVRN
9	lacrimal gland adenoid cystic carcinoma	7.6	SHMT1 RPL39L RPL39 PSPH NFIB LYPD5

Graphical network of the top 20 diseases related to Lacrimal Gland Adenocarcinoma:

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Symptoms & Phenotypes for Lacrimal Gland Adenocarcinoma

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Drugs & Therapeutics for Lacrimal Gland Adenocarcinoma

Search Clinical Trials, NIH Clinical Center for Lacrimal Gland Adenocarcinoma

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Genetic Tests for Lacrimal Gland Adenocarcinoma

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Anatomical Context for Lacrimal Gland Adenocarcinoma

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Publications for Lacrimal Gland Adenocarcinoma

Articles related to Lacrimal Gland Adenocarcinoma:

(show all 22)

#	Title	Authors	PMID	Year
1	Title: Clinico-pathological and survival profiles of orbito-ocular tumors in Enugu Nigeria. Is there an emerging trend? ⁶²	Uche NJ...Uche EO	35222873	2022
2	De novo adenocarcinoma of the lacrimal gland: Case report. ⁶²	Issiaka M...El Belhadji M	33868676	2021
3	Primary De novo ductal adenocarcinoma of the lacrimal gland. ⁶²	Tripathy D...Mittal R	33186791	2021
4	Bilateral Poorly Differentiated Adenocarcinoma of the Lacrimal Gland With Tumor Regression After Treatment With Pembrolizumab. ⁶²	Tran AQ...Lee BW	32282640	2020
5	Periorbital squamous cell carcinoma with simultaneous adenocarcinoma in the right orbit. ⁶²	Ho CLT...Deshmukh M	32062504	2020
6	Primary poorly differentiated lacrimal gland adenocarcinoma in left ocular region: A rare case report. ⁶²	Xia F...Ma X	30212949	2018
7	Lacrimal gland adenocarcinoma responding to checkpoint inhibition and androgen deprivation. ⁶²	Bulbul A	30159157	2018
8	Surgical excision of a feline orbital lacrimal gland adenocarcinoma with adjunctive cryotherapy and carboplatin-impregnated bead implantation. ⁶²	Dorbandt DM...Hamor RE	28799265	2018
9	Primary ductal adenocarcinoma of lacrimal gland: Two case reports and review of the literature. ⁶²	Yang HY...Liu CJ	29675349	2018
10	Adenocarcinoma of the lacrimal gland: a case report. ⁶²	Touil A...Benjaafar N	28889800	2017
11	A benign presentation of primary ductal adenocarcinoma of lacrimal gland: A rare malignancy. ⁶²	Lau LL...Ahmad SS	26669339	2015
12	GCDFP-15, AR, and Her-2 as biomarkers for primary ductal adenocarcinoma of the lacrimal gland: a Chinese case and literature review. ⁶²	Zhu MM...Teng XD	25999735	2015
13	CORE needle biopsy of orbital tumors. ⁶²	Yarovoy AA...Golubeva OV	23515750	2013
14	Clinicopathologic and immunohistochemical features of primary ductal adenocarcinoma of lacrimal gland: five new cases and review of literature. ⁶²	Kubota T...Ichihara S	23613093	2013
15	[Clinical analysis for the treatment of 63 cases of orbital tumors in Xinjiang]. ⁶²	Xue Z...Liu GY	23336410	2012
16	Basal cell adenocarcinoma of lacrimal gland. ⁶²	Muduly DK...Samantara S	22132848	2011
17	[Adenocarcinoma of the lacrimal gland in bilateral retinoblastoma treated with external radiotherapy: a case report]. ⁶²	Bubella DM...Lodato G	21978539	2011
18	Primary lacrimal gland adenocarcinoma of the third eyelid in a horse. ⁶²	Mathes RL...Anthony Moore P	21199279	2011
19	[Adenocarcinoma in a pleomorphic adenoma of the lacrimal gland: a case study]. ⁶²	Galatoire O...Morax S	16249774	2005
20	Orbital adenocarcinoma of lacrimal gland origin in a dog. ⁶²	Wang FI...Liu YS	11289213	2001
21	Adenocarcinoma of lacrimal gland. ⁶²	Wright JE	8035974	1994
22	Adenocarcinoma of lacrimal gland. ⁶²	RUBIN IE	20256346	1947

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Genes for Lacrimal Gland Adenocarcinoma

Genes related to Lacrimal Gland Adenocarcinoma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	RPL39L	Ribosomal Protein L39 Like	Protein Coding	6.5	DISEASES inferred ¹⁴
2	RPL39	Ribosomal Protein L39	Protein Coding	5.98	DISEASES inferred ¹⁴
3	LYPD5	LY6/PLAUR Domain Containing 5	Protein Coding	5.94	DISEASES inferred ¹⁴
4	PSPH	Phosphoserine Phosphatase	Protein Coding	5.77	DISEASES inferred ¹⁴
5	LVRN	Laeverin	Protein Coding	5.64	DISEASES inferred ¹⁴
6	AHCYL2	Adenosylhomocysteinase Like 2	Protein Coding	5.53	DISEASES inferred ¹⁴
7	CMTM2	CKLF Like MARVEL Transmembrane Domain Containing 2	Protein Coding	5.4	DISEASES inferred ¹⁴
8	BPTF	Bromodomain PHD Finger Transcription Factor	Protein Coding	5.26	DISEASES inferred ¹⁴
9	NFIB	Nuclear Factor I B	Protein Coding	5	DISEASES inferred ¹⁴
10	CPLX2	Complexin 2	Protein Coding	4.96	DISEASES inferred ¹⁴
11	SHMT1	Serine Hydroxymethyltransferase 1	Protein Coding	4.92	DISEASES inferred ¹⁴
12	LACC1	Laccase Domain Containing 1	Protein Coding	4.86	DISEASES inferred ¹⁴

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Variations for Lacrimal Gland Adenocarcinoma

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Expression for Lacrimal Gland Adenocarcinoma

Search GEO for disease gene expression data for Lacrimal Gland Adenocarcinoma.

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Pathways for Lacrimal Gland Adenocarcinoma

Pathways related to Lacrimal Gland Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Regulation of expression of SLITs and ROBOs ⁶⁶ Show member pathways Metabolism of amino acids and derivatives ⁶⁶ Signaling by ROBO receptors ⁶⁶	12.34	SHMT1 RPL39L RPL39 PSPH
2	Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics ⁶⁰ Show member pathways Antimetabolite Pathway - Folate Cycle, Pharmacodynamics ⁶⁰ One-carbon metabolism ⁷⁴ tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate ⁶¹	11.03	SHMT1 AHCYL2
3	One-carbon metabolism and related pathways ⁷⁴ Show member pathways dTMP de novo biosynthesis (mitochondrial) ⁶¹ Trans-sulfuration, one-carbon metabolism and related pathways ⁷⁴	10.89	SHMT1 PSPH AHCYL2
4	serine and glycine biosynthesis ⁶¹ Show member pathways Amino acid metabolism in triple-negative breast cancer cells ⁷⁴ L-serine biosynthesis I ⁶¹ Serine biosynthesis ⁶⁶ serine biosynthesis (phosphorylated route) ⁶¹ Serine metabolism ⁷⁴ superpathway of L-serine and glycine biosynthesis I ⁶¹	10.58	SHMT1 PSPH

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GO Terms for Lacrimal Gland Adenocarcinoma

Biological processes related to Lacrimal Gland Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	one-carbon metabolic process	GO:0006730	9.26	SHMT1 AHCYL2
2	L-serine metabolic process	GO:0006563	8.92	SHMT1 PSPH

Molecular functions related to Lacrimal Gland Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hydrolase activity	GO:0016787	9.02	SHMT1 PSPH LVRN LACC1 AHCYL2

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Sources for Lacrimal Gland Adenocarcinoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

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⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

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¹⁵ DrugBank

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¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

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⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

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⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LCR009 MIFTS: 21	Lacrimal Gland Adenocarcinoma Categories: Cancer diseases, Endocrine diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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