MCID: LCR006
MIFTS: 29

Lacrimal Gland Adenoid Cystic Carcinoma

Categories: Neuronal diseases, Cancer diseases, Eye diseases, Endocrine diseases

Aliases & Classifications for Lacrimal Gland Adenoid Cystic Carcinoma

MalaCards integrated aliases for Lacrimal Gland Adenoid Cystic Carcinoma:

Name: Lacrimal Gland Adenoid Cystic Carcinoma 12 15
Adenoid Cystic Carcinoma of Lacrimal Gland 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4870
NCIt 50 C4540
SNOMED-CT 68 254987003
UMLS 73 C0346340

Summaries for Lacrimal Gland Adenoid Cystic Carcinoma

MalaCards based summary : Lacrimal Gland Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of lacrimal gland, is related to adenoid cystic carcinoma and adenoiditis, and has symptoms including pain An important gene associated with Lacrimal Gland Adenoid Cystic Carcinoma is NOTCH2 (Notch 2), and among its related pathways/superpathways are Neuroscience and Diseases of glycosylation. Affiliated tissues include eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Lacrimal Gland Adenoid Cystic Carcinoma

Diseases related to Lacrimal Gland Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 10.7
2 adenoiditis 10.7
3 myoepithelioma 10.1
4 nodular regenerative hyperplasia 9.8 NOTCH1 NOTCH2
5 lacrimal gland adenocarcinoma 9.8 BPTF NOTCH2
6 lung adenoma 9.7 NOTCH1 NOTCH2
7 alagille syndrome 1 9.5 NOTCH1 NOTCH2
8 hajdu-cheney syndrome 9.3 NOTCH1 NOTCH2

Graphical network of the top 20 diseases related to Lacrimal Gland Adenoid Cystic Carcinoma:



Diseases related to Lacrimal Gland Adenoid Cystic Carcinoma

Symptoms & Phenotypes for Lacrimal Gland Adenoid Cystic Carcinoma

UMLS symptoms related to Lacrimal Gland Adenoid Cystic Carcinoma:


pain

GenomeRNAi Phenotypes related to Lacrimal Gland Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.73 GLUD1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.73 BPTF
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.73 GLUD1 NOTCH1 BPTF
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.73 GLUD1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.73 BPTF
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.73 BPTF
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.73 NOTCH1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.73 BPTF
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.73 NOTCH1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.73 NOTCH1
11 Increased Nanog expression GR00371-A-1 9.02 BPTF
12 Increased Nanog expression GR00371-A-2 9.02 NOTCH2 BPTF
13 Increased Nanog expression GR00371-A-4 9.02 NOTCH2 BPTF

MGI Mouse Phenotypes related to Lacrimal Gland Adenoid Cystic Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.35 BPTF GLUD1 NOTCH1 NOTCH2 SOD2
2 pigmentation MP:0001186 8.8 NOTCH1 NOTCH2 SOD2

Drugs & Therapeutics for Lacrimal Gland Adenoid Cystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Lacrimal Gland Adenoid Cystic Carcinoma

Genetic Tests for Lacrimal Gland Adenoid Cystic Carcinoma

Anatomical Context for Lacrimal Gland Adenoid Cystic Carcinoma

MalaCards organs/tissues related to Lacrimal Gland Adenoid Cystic Carcinoma:

41
Eye

Publications for Lacrimal Gland Adenoid Cystic Carcinoma

Articles related to Lacrimal Gland Adenoid Cystic Carcinoma:

(show all 20)
# Title Authors Year
1
miR-93-5p enhance lacrimal gland adenoid cystic carcinoma cell tumorigenesis by targeting BRMS1L. ( 29760585 )
2018
2
Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma. ( 28820917 )
2017
3
Intra-arterial Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma. ( 27898620 )
2017
4
Expression of Autophagy and Reactive Oxygen Species-Related Proteins in Lacrimal Gland Adenoid Cystic Carcinoma. ( 26847304 )
2016
5
Expression of metabolism-related proteins in lacrimal gland adenoid cystic carcinoma. ( 25780012 )
2015
6
Adjuvant Radiotherapy with Three-Dimensional Conformal Radiotherapy of Lacrimal Gland Adenoid Cystic Carcinoma. ( 26557600 )
2015
7
Influence of ribosomal protein L39-L in the drug resistance mechanisms of lacrimal gland adenoid cystic carcinoma cells. ( 24998577 )
2014
8
Does Intra-arterial Chemotherapy Improve Survival for Lacrimal Gland Adenoid Cystic Carcinoma? ( 24268857 )
2014
9
Lacrimal gland adenoid cystic carcinoma with high-grade transformation to myoepithelial carcinoma: report of a case and review of literature. ( 22829347 )
2013
10
Long-term outcomes of neoadjuvant intra-arterial cytoreductive chemotherapy for lacrimal gland adenoid cystic carcinoma. ( 23582989 )
2013
11
Multiple cutaneous metastases: a rare and late sequelae of lacrimal gland adenoid cystic carcinoma. ( 23899266 )
2013
12
Disease recurrence after intraarterial chemotherapy in 2 patients with adenoid cystic carcinoma of lacrimal gland. ( 23561610 )
2013
13
Influence of Ginkgo biloba extract on the proliferation, apoptosis of ACC-2 cell and Survivin gene expression in adenoid cystic carcinoma of lacrimal gland. ( 23146805 )
2012
14
American Joint Committee on Cancer classification predicts outcome of patients with lacrimal gland adenoid cystic carcinoma. ( 19395039 )
2009
15
Adjuvant chemotherapy in lacrimal gland adenoid cystic carcinoma. ( 19743515 )
2009
16
[Protein expression of p53, bcl-2, and bax in adenoid cystic carcinoma of lacrimal gland]. ( 19062739 )
2008
17
Clinical analysis of the effect of intraarterial cytoreductive chemotherapy in the treatment of lacrimal gland adenoid cystic carcinoma. ( 16386975 )
2006
18
Microdissection genotyping analysis of the effect of intraarterial cytoreductive chemotherapy in the treatment of lacrimal gland adenoid cystic carcinoma. ( 16386976 )
2006
19
Clinical and microdissection genotyping analyses of the effect of intra-arterial cytoreductive chemotherapy in the treatment of lacrimal gland adenoid cystic carcinoma. ( 17057810 )
2005
20
Lacrimal gland adenoid cystic carcinoma: intracranial and extracranial en bloc resection. ( 6269133 )
1981

Variations for Lacrimal Gland Adenoid Cystic Carcinoma

Expression for Lacrimal Gland Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Lacrimal Gland Adenoid Cystic Carcinoma.

Pathways for Lacrimal Gland Adenoid Cystic Carcinoma

Pathways related to Lacrimal Gland Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1 11.87 GLUD1 NOTCH1 NOTCH2
2
Show member pathways
11.67 NOTCH1 NOTCH2
3
Show member pathways
11.65 NOTCH1 NOTCH2
4 11.63 NOTCH1 NOTCH2
5
Show member pathways
11.56 NOTCH1 NOTCH2
6 11.5 NOTCH1 NOTCH2
7 11.47 NOTCH1 NOTCH2
8 11.38 NOTCH1 NOTCH2
9 11.27 NOTCH1 NOTCH2
10 11.15 NOTCH1 NOTCH2
11 10.5 NOTCH1 NOTCH2
12 10.05 NOTCH1 NOTCH2

GO Terms for Lacrimal Gland Adenoid Cystic Carcinoma

Biological processes related to Lacrimal Gland Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell cycle arrest GO:0007050 9.46 NOTCH1 NOTCH2
2 Notch signaling pathway GO:0007219 9.43 NOTCH1 NOTCH2
3 mitochondrion organization GO:0007005 9.4 GLUD1 SOD2
4 endoderm development GO:0007492 9.37 BPTF NOTCH1
5 positive regulation of Ras protein signal transduction GO:0046579 9.32 NOTCH1 NOTCH2
6 pulmonary valve morphogenesis GO:0003184 9.26 NOTCH1 NOTCH2
7 Notch signaling involved in heart development GO:0061314 9.16 NOTCH1 NOTCH2
8 regulation of developmental process GO:0050793 8.96 NOTCH1 NOTCH2
9 negative regulation of growth rate GO:0045967 8.62 NOTCH1 NOTCH2

Sources for Lacrimal Gland Adenoid Cystic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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