MCID: LCR006
MIFTS: 32

Lacrimal Gland Adenoid Cystic Carcinoma

Categories: Cancer diseases, Endocrine diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Lacrimal Gland Adenoid Cystic Carcinoma

MalaCards integrated aliases for Lacrimal Gland Adenoid Cystic Carcinoma:

Name: Lacrimal Gland Adenoid Cystic Carcinoma 12 15 17
Adenoid Cystic Carcinoma of Lacrimal Gland 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4870
NCIt 51 C4540
UMLS 74 C0346340

Summaries for Lacrimal Gland Adenoid Cystic Carcinoma

MalaCards based summary : Lacrimal Gland Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of lacrimal gland, is related to adenoid cystic carcinoma and myoepithelial carcinoma, and has symptoms including pain An important gene associated with Lacrimal Gland Adenoid Cystic Carcinoma is NOTCH2 (Notch Receptor 2), and among its related pathways/superpathways are Neuroscience and Pre-NOTCH Expression and Processing. Affiliated tissues include bone, eye and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Lacrimal Gland Adenoid Cystic Carcinoma

Diseases related to Lacrimal Gland Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 10.9
2 myoepithelial carcinoma 10.2
3 degos 'en cocarde' erythrokeratoderma 10.2
4 aplasia cutis congenita, nonsyndromic 10.2
5 nodular regenerative hyperplasia 10.0 NOTCH1 NOTCH2
6 lung adenoma 10.0 NOTCH1 NOTCH2
7 alagille syndrome 1 10.0 NOTCH1 NOTCH2
8 hajdu-cheney syndrome 9.9 NOTCH1 NOTCH2
9 dowling-degos disease 9.9 NOTCH1 NOTCH2
10 lacrimal gland adenocarcinoma 9.8 BPTF PSPH
11 lacrimal system cancer 9.8 BPTF PSPH
12 lacrimal gland carcinoma 9.8 BPTF PSPH
13 mouth disease 9.7 NOTCH1 NOTCH2

Graphical network of the top 20 diseases related to Lacrimal Gland Adenoid Cystic Carcinoma:



Diseases related to Lacrimal Gland Adenoid Cystic Carcinoma

Symptoms & Phenotypes for Lacrimal Gland Adenoid Cystic Carcinoma

UMLS symptoms related to Lacrimal Gland Adenoid Cystic Carcinoma:


pain

GenomeRNAi Phenotypes related to Lacrimal Gland Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.36 GLUD1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.36 BPTF
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.36 BPTF GLUD1 NOTCH1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.36 GLUD1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.36 BPTF
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.36 BPTF
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.36 NOTCH1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.36 BPTF
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.36 NOTCH1

MGI Mouse Phenotypes related to Lacrimal Gland Adenoid Cystic Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.88 BPTF GLUD1 NOTCH1 NOTCH2 PSPH SOD2
2 embryo MP:0005380 9.73 BPTF NOTCH1 NOTCH2 PSPH
3 integument MP:0010771 9.67 NOTCH1 NOTCH2 PSPH SOD2
4 liver/biliary system MP:0005370 9.62 NOTCH1 NOTCH2 PSPH SOD2
5 muscle MP:0005369 9.56 NOTCH1 NOTCH2 PSPH SOD2
6 pigmentation MP:0001186 9.33 NOTCH1 NOTCH2 SOD2
7 renal/urinary system MP:0005367 9.26 NOTCH1 NOTCH2 PSPH SOD2
8 vision/eye MP:0005391 8.92 NOTCH1 NOTCH2 PSPH SOD2

Drugs & Therapeutics for Lacrimal Gland Adenoid Cystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Lacrimal Gland Adenoid Cystic Carcinoma

Genetic Tests for Lacrimal Gland Adenoid Cystic Carcinoma

Anatomical Context for Lacrimal Gland Adenoid Cystic Carcinoma

MalaCards organs/tissues related to Lacrimal Gland Adenoid Cystic Carcinoma:

42
Bone, Eye, Bone Marrow, Lung

Publications for Lacrimal Gland Adenoid Cystic Carcinoma

Articles related to Lacrimal Gland Adenoid Cystic Carcinoma:

(show all 23)
# Title Authors Year
1
Long-term Outcomes of Globe-Preserving Surgery With Proton Beam Radiation for Adenoid Cystic Carcinoma of Lacrimal Gland. ( 30709640 )
2019
2
miR-93-5p enhance lacrimal gland adenoid cystic carcinoma cell tumorigenesis by targeting BRMS1L. ( 29760585 )
2018
3
Long-Term Outcomes of Eye-Sparing Surgery for Adenoid Cystic Carcinoma of Lacrimal Gland. ( 28221296 )
2018
4
Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma. ( 28820917 )
2017
5
Intra-arterial Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma. ( 27898620 )
2017
6
Expression of Autophagy and Reactive Oxygen Species-Related Proteins in Lacrimal Gland Adenoid Cystic Carcinoma. ( 26847304 )
2016
7
Expression of metabolism-related proteins in lacrimal gland adenoid cystic carcinoma. ( 25780012 )
2015
8
Adjuvant Radiotherapy with Three-Dimensional Conformal Radiotherapy of Lacrimal Gland Adenoid Cystic Carcinoma. ( 26557600 )
2015
9
Recurred adenoid cystic carcinoma of lacrimal gland with aggressive local invasion to the maxillary bone marrow without increased uptake in PET-CT. ( 25646064 )
2015
10
Influence of ribosomal protein L39-L in the drug resistance mechanisms of lacrimal gland adenoid cystic carcinoma cells. ( 24998577 )
2014
11
Does intra-arterial chemotherapy improve survival for lacrimal gland adenoid cystic carcinoma? ( 24268857 )
2014
12
Disease recurrence after intraarterial chemotherapy in 2 patients with adenoid cystic carcinoma of lacrimal gland. ( 23561610 )
2013
13
Lacrimal gland adenoid cystic carcinoma with high-grade transformation to myoepithelial carcinoma: report of a case and review of literature. ( 22829347 )
2013
14
Long-term outcomes of neoadjuvant intra-arterial cytoreductive chemotherapy for lacrimal gland adenoid cystic carcinoma. ( 23582989 )
2013
15
Multiple cutaneous metastases: a rare and late sequelae of lacrimal gland adenoid cystic carcinoma. ( 23899266 )
2013
16
Influence of Ginkgo biloba extract on the proliferation, apoptosis of ACC-2 cell and Survivin gene expression in adenoid cystic carcinoma of lacrimal gland. ( 23146805 )
2012
17
Adjuvant chemotherapy in lacrimal gland adenoid cystic carcinoma. ( 19743515 )
2009
18
American Joint Committee on Cancer classification predicts outcome of patients with lacrimal gland adenoid cystic carcinoma. ( 19395039 )
2009
19
Clinical analysis of the effect of intraarterial cytoreductive chemotherapy in the treatment of lacrimal gland adenoid cystic carcinoma. ( 16386975 )
2006
20
Microdissection genotyping analysis of the effect of intraarterial cytoreductive chemotherapy in the treatment of lacrimal gland adenoid cystic carcinoma. ( 16386976 )
2006
21
Clinical and microdissection genotyping analyses of the effect of intra-arterial cytoreductive chemotherapy in the treatment of lacrimal gland adenoid cystic carcinoma. ( 17057810 )
2005
22
Adenoid cystic carcinoma of lacrimal gland. ( 6304387 )
1983
23
Lacrimal gland adenoid cystic carcinoma: intracranial and extracranial en bloc resection. ( 6269133 )
1981

Variations for Lacrimal Gland Adenoid Cystic Carcinoma

Expression for Lacrimal Gland Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Lacrimal Gland Adenoid Cystic Carcinoma.

Pathways for Lacrimal Gland Adenoid Cystic Carcinoma

GO Terms for Lacrimal Gland Adenoid Cystic Carcinoma

Biological processes related to Lacrimal Gland Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Notch signaling pathway GO:0007219 9.43 NOTCH1 NOTCH2
2 cellular amino acid biosynthetic process GO:0008652 9.4 GLUD1 PSPH
3 endoderm development GO:0007492 9.37 BPTF NOTCH1
4 positive regulation of Ras protein signal transduction GO:0046579 9.32 NOTCH1 NOTCH2
5 pulmonary valve morphogenesis GO:0003184 9.26 NOTCH1 NOTCH2
6 Notch signaling involved in heart development GO:0061314 9.16 NOTCH1 NOTCH2
7 regulation of developmental process GO:0050793 8.96 NOTCH1 NOTCH2
8 negative regulation of growth rate GO:0045967 8.62 NOTCH1 NOTCH2

Molecular functions related to Lacrimal Gland Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 8.8 NOTCH1 NOTCH2 PSPH

Sources for Lacrimal Gland Adenoid Cystic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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