Lactic Acidosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LCT001 MIFTS: 52	Lactic Acidosis Categories: Metabolic diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Lactic Acidosis

MalaCards integrated aliases for Lactic Acidosis:

Name: Lactic Acidosis ¹² ²⁹ ⁶ ¹⁵

Acidosis, Lactic ⁴⁴ ⁷³

Acidosis Lactic ⁵⁵

Classifications:

MalaCards categories:
Global: Metabolic diseases Rare diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Endocrine, nutritional and metabolic diseases

Metabolic disorders

Other disorders of fluid, electrolyte and acid-base balance

Acidosis

External Ids:

Disease Ontology ¹² DOID:3650

ICD10 ³³ E87.2

MeSH ⁴⁴ D000140

NCIt ⁵⁰ C98969

SNOMED-CT ⁶⁸ 91273001

UMLS ⁷³ C0001125

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Summaries for Lactic Acidosis

Disease Ontology : ¹² A metabolic acidosis characterized by buildup of lactate.

MalaCards based summary : Lactic Acidosis, also known as acidosis, lactic, is related to myopathy, lactic acidosis, and sideroblastic anemia 1 and myopathy, lactic acidosis, and sideroblastic anemia 3. An important gene associated with Lactic Acidosis is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Metformin and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and kidney.

Wikipedia : ⁷⁶ Lactic acidosis is a medical condition characterized by the buildup of lactate (especially L-lactate) in... more...

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Related Diseases for Lactic Acidosis

Diseases in the Lactic Acidosis family:

Lactic Acidosis, Chronic Adult Form

Lactic Acidosis Congenital Infantile

Diseases related to Lactic Acidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 317)

#	Related Disease	Score	Top Affiliating Genes
1	myopathy, lactic acidosis, and sideroblastic anemia 1	34.3	PUS1 YARS2
2	myopathy, lactic acidosis, and sideroblastic anemia 3	33.9	MT-ATP6 MT-CO3 MT-ND4
3	mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	33.7	LARS2 MT-ATP6 MT-CO3 MT-ND1 MT-ND4 MT-ND5
4	myopathy, lactic acidosis, and sideroblastic anemia	33.6	MT-ATP6 MT-CO3 MT-ND4 PUS1 YARS2
5	pyruvate dehydrogenase e1-alpha deficiency	33.5	PC PDHA1 PDHX
6	mitochondrial myopathy	31.5	ISCU MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
7	leigh syndrome	31.0	DLD MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
8	sideroblastic anemia	30.9	LARS2 MT-ATP6 PUS1 YARS2
9	mitochondrial encephalomyopathy	30.9	LARS2 MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
10	neuropathy	30.1	MT-ATP6 MT-ND1 MT-ND4 MT-ND5 POLG
11	alpha-ketoglutarate dehydrogenase deficiency	30.1	DLD PDHA1
12	myoclonic epilepsy associated with ragged-red fibers	30.0	MT-ND4 MT-ND5 POLG
13	optic nerve disease	29.7	KARS MT-ATP6 MT-ND1 MT-ND4 MT-ND5
14	kearns-sayre syndrome	29.5	MT-ATP6 MT-CYB MT-ND1 MT-ND4 MT-ND5 POLG
15	mitochondrial myopathy with lactic acidosis	12.7
16	myopathy, lactic acidosis, and sideroblastic anemia 2	12.7
17	myopathy with lactic acidosis, hereditary	12.6
18	hydrops, lactic acidosis, and sideroblastic anemia	12.5
19	encephalopathy, neonatal severe, with lactic acidosis and brain abnormalities	12.5
20	neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures	12.5
21	hyperglycinemia, lactic acidosis, and seizures	12.5
22	lactic acidosis congenital infantile	12.3
23	pyruvate carboxylase deficiency	12.2
24	lactic acidosis, chronic adult form	12.2
25	succinic acidemia lactic acidosis congenital	12.2
26	mitochondrial dna depletion syndrome 9	12.2
27	gracile syndrome	12.1
28	dihydrolipoamide dehydrogenase deficiency	12.1
29	combined oxidative phosphorylation deficiency 10	12.0
30	maple syrup urine disease	11.9
31	leigh syndrome, french canadian type	11.9
32	combined oxidative phosphorylation deficiency 18	11.8
33	mitochondrial phosphate carrier deficiency	11.8
34	combined oxidative phosphorylation deficiency 19	11.8
35	sengers syndrome	11.7
36	pyruvate dehydrogenase phosphatase deficiency	11.6
37	pyruvate dehydrogenase e1-beta deficiency	11.6
38	combined oxidative phosphorylation deficiency 3	11.5
39	beriberi	11.5
40	mitochondrial complex iv deficiency	11.4
41	mitochondrial complex i deficiency	11.4
42	lipoyltransferase 1 deficiency	11.4
43	mitochondrial complex iii deficiency	11.4
44	paracetamol poisoning	11.4
45	combined oxidative phosphorylation deficiency 2	11.4
46	mitochondrial complex iii deficiency, nuclear type 6	11.3
47	mitochondrial complex iii deficiency, nuclear type 1	11.2
48	hsd10 mitochondrial disease	11.2
49	barth syndrome	11.2
50	multiple mitochondrial dysfunctions syndrome 1	11.2

Graphical network of the top 20 diseases related to Lactic Acidosis:

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Symptoms & Phenotypes for Lactic Acidosis

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Drugs & Therapeutics for Lactic Acidosis

Drugs for Lactic Acidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 187)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Metformin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

657-24-9

14219 4091

Tramadol

Approved, Investigational

Phase 4

27203-92-5

33741

Parecoxib

Approved

Phase 4

198470-84-7

Celecoxib

Approved, Investigational

Phase 4

169590-42-5

2662

Adefovir Dipivoxil

Approved, Investigational

Phase 4

142340-99-6

60871

Telbivudine

Approved, Investigational

Phase 4

3424-98-4

159269

Stavudine

Approved, Investigational

Phase 4

3056-17-5

18283

Fenoldopam

Approved

Phase 4

67227-57-0, 67227-56-9

3341

Dopamine

Approved

Phase 4,Not Applicable

51-61-6, 62-31-7

681

Lamivudine

Approved, Investigational

Phase 4

134678-17-4

60825

Entecavir

Approved, Investigational

Phase 4

142217-69-4

153941

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

59-30-3

6037

Thiamine

Approved, Investigational, Nutraceutical, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1

59-43-8, 70-16-6

1130

Riboflavin

Approved, Investigational, Nutraceutical, Vet_approved

Phase 4

83-88-5

493570

Adefovir

Investigational

Phase 4

106941-25-7

Antipsychotic Agents

Phase 4

Psychotropic Drugs

Phase 4

Hypoglycemic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Tranquilizing Agents

Phase 4

Central Nervous System Depressants

Phase 4,Phase 2,Phase 3,Not Applicable

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Analgesics

Phase 4,Phase 2,Phase 3

insulin

Phase 4,Phase 2,Not Applicable

Cyclooxygenase 2 Inhibitors

Phase 4

Analgesics, Opioid

Phase 4

Narcotics

Phase 4

Anti-Inflammatory Agents

Phase 4,Phase 1,Not Applicable

Peripheral Nervous System Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Antirheumatic Agents

Phase 4

Cyclooxygenase Inhibitors

Phase 4

Analgesics, Non-Narcotic

Phase 4

Insulin, Globin Zinc

Phase 4,Phase 2,Not Applicable

Antiviral Agents

Phase 4

Nucleic Acid Synthesis Inhibitors

Phase 4

Reverse Transcriptase Inhibitors

Phase 4

Anti-Infective Agents

Phase 4

Anti-Retroviral Agents

Phase 4

Liver Extracts

Phase 4,Not Applicable

Vasodilator Agents

Phase 4,Phase 1,Phase 2,Not Applicable

Vitamin B Complex

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Photosensitizing Agents

Phase 4

Vitamins

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Vitamin B2

Phase 4

Micronutrients

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Vitamin B9

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Thiamin

Phase 4,Phase 2,Phase 3,Phase 1

Folate

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

carnitine

Phase 4

Trace Elements

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Dermatologic Agents

Phase 4

Interventional clinical trials:

(show top 50) (show all 77)

#	Name	Status	NCT ID	Phase	Drugs
1	Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics	Unknown status	NCT00845936	Phase 4	Metformin
2	Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery	Unknown status	NCT01930318	Phase 4	parecoxib
3	Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial	Unknown status	NCT01799486	Phase 4	Telbivudine;Enecavir;Adefovir
4	Lactate Metabolism Study in HIV Infected Persons	Completed	NCT00202228	Phase 4	cofactor supplementation (thiamine, riboflavin, L-carnitine)
5	Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass	Completed	NCT00747331	Phase 4	Fenoldopam mesilate;Placebo
6	Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS)	Completed	NCT01831934	Phase 4
7	Type 2 Diabetes and Ambulatory Surgery Patients	Completed	NCT03179254	Phase 4	Metformin continue;Metformin discontinue
8	The Metformin in Coronary Artery Bypass Graft (CABG) (MetCAB) Trial	Completed	NCT01438723	Phase 4	Metformin;Placebo
9	Body Weight Effects on Glucophage's Efficacy in Chinese Diagnosed T2DM Patients	Completed	NCT00778622	Phase 4	Metformin XR
10	Lactic Acidosis During Entecavir(ETV)Treatment	Terminated	NCT01354652	Phase 4	entecavir, lamivudine
11	Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis	Completed	NCT00004490	Phase 3	sodium dichloroacetate
12	RBC Transfusion in Severe Anemia With Lactic Acidosis	Completed	NCT01586923	Phase 3
13	Metformin Therapy for Overweight Adolescents With Type 1 Diabetes	Completed	NCT01881828	Phase 3	Metformin (glucophage)
14	Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:	Recruiting	NCT02616484	Phase 3	Dichloroacetate (DCA)
15	Alcohol: Thiamine and or Magnesium 1	Recruiting	NCT03466528	Phase 2, Phase 3	Magnesium Sulfate;Pabrinex
16	Patients With Heart Failure ANd Type 2 Diabetes Treated With Placebo Or Metformin (PHANTOM) Pilot Study	Terminated	NCT00325910	Phase 3	Metformin
17	Metformin and Simvastatin in Addition to Fulvestrant	Unknown status	NCT03192293	Phase 2	Metformin/Simvastatin/Fulvestrant
18	Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome	Unknown status	NCT00068913	Phase 2	Dichloroacetate
19	Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study	Unknown status	NCT02848508	Phase 2	Metformin
20	Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes	Completed	NCT00887562	Phase 2	Idebenone;Idebenone
21	Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients	Completed	NCT01262196	Phase 2	MP4OX;Saline
22	Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients	Completed	NCT01004198	Phase 2	MP4OX;MP4OX;Ringers Lactate solution
23	Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia	Completed	NCT00004493	Phase 2	sodium dichloroacetate
24	SELESTIAL: Trial of Insulin to Control Blood Sugar After Acute Stroke Using Magnetic Resonance Imaging (MRI) End-Points	Completed	NCT00124826	Phase 2	Insulin
25	Thiamine as a Metabolic Resuscitator in Septic Shock	Completed	NCT01070810	Phase 1, Phase 2	D5W;Thiamine
26	The KHENERGY Study	Completed	NCT02909400	Phase 2	KH176;placebo
27	Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest	Completed	NCT01509040	Phase 1, Phase 2
28	Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest	Recruiting	NCT02974257	Phase 2	Thiamine
29	Metformin for the Minimization of Geographic Atrophy Progression in Patients With AMD	Recruiting	NCT02684578	Phase 2	Metformin
30	The Effects of Neoadjuvant Metformin on Tumour Cell Proliferation and Tumour Progression in Pancreatic Ductal Adenocarcinoma	Not yet recruiting	NCT02978547	Phase 2	Metformin Hydrochloride 500Mg Tablet
31	Insulin Treatment in Diabetic Older People With Heart Failure.	Not yet recruiting	NCT03665350	Phase 2	Insulin
32	Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study	Not yet recruiting	NCT03710343	Phase 2	Metformin;Placebo Oral Tablet
33	A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease	Terminated	NCT02473445	Phase 2	Cysteamine Bitartrate
34	Phase 2c Dose Comparison Study of MP4OX in Trauma	Withdrawn	NCT01973504	Phase 2	MP4OX;Control
35	A Dose-escalating Clinical Trial With KH176	Completed	NCT02544217	Phase 1	KH176;placebo
36	A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours	Completed	NCT00566410	Phase 1	Dichloroacetate
37	Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL)	Completed	NCT01324180	Phase 1	Metformin;Vincristine;Dexamethasone;PEG-asparaginase;Doxorubicin;Intrathecal chemotherapy
38	Thiamine Supplementation in Patients With Septic Shock	Recruiting	NCT03122678	Phase 1	Thiamine;Placebos
39	Nitroglycerin Infusion During Cardiac Surgery	Unknown status	NCT01901419	Not Applicable	Nitroglycerin infusion
40	Mitochondrial nt3243 A>G Mutation in Taiwan	Unknown status	NCT02114554
41	Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital	Completed	NCT01580111	Not Applicable
42	Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media	Completed	NCT01873859	Not Applicable	Metformin
43	Glucose-insulin-potassium Therapy Improves Lactic Acidosis in Liver Transplantation	Completed	NCT03522181	Not Applicable
44	Study On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis	Completed	NCT00942123
45	Metformin Treatment, Renal Function and Lactic Acidosis	Completed	NCT01358994
46	Lactic Acidosis During and After Seizures	Completed	NCT01833247
47	Dichloroacetate Kinetics, Metabolism and Toxicology	Completed	NCT00015015		Dichloroacetate
48	Pharmacotoxicology of Trichloroethylene Metabolites	Completed	NCT00874276	Not Applicable	Dichloroacetate (DCA)
49	Lactate Acidosis in Postoperative Hearts	Completed	NCT03025659
50	Study of Blood Lactate Levels in Patients Treated With Antipsychotics	Completed	NCT01139463		Haloperidol or olanzapine

Search NIH Clinical Center for Lactic Acidosis

Cochrane evidence based reviews: acidosis, lactic

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Genetic Tests for Lactic Acidosis

Genetic tests related to Lactic Acidosis:

#	Genetic test	Affiliating Genes
1	Lactic Acidosis ²⁹

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Anatomical Context for Lactic Acidosis

MalaCards organs/tissues related to Lactic Acidosis:

⁴¹

Liver, Heart, Kidney, Brain, B Cells, Lung, Prostate

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Publications for Lactic Acidosis

Articles related to Lactic Acidosis:

(show top 50) (show all 1213)

#	Title	Authors	Year
1	The Usefulness of Muscle Biopsy in Initial Diagnostic Evaluation of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes. ( 30554496 )	Baek MS...Lee YM	2019
2	Multiorgan Failure and Refractory Lactic Acidosis due to <i>Pasteurella multocida</i> Septicemia in a Patient with No Animal Exposure. ( 29765783 )	Pena D....Khaja M.	2018
3	Lactic Acidosis and Asthma Exacerbation. ( 29801682 )	MartA-nez-TAcbar M.J....GarcA-a-PachA^n E.	2018
4	Beware of beta! A case of salbutamol-induced lactic acidosis in severe asthma. ( 29914901 )	Sharif Z....Al-Alawi M.	2018
5	Survival analysis of a cohort of Chinese patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) based on clinical features. ( 29406897 )	Zhang Z....Wang Z.	2018
6	Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( 29301418 )	Levine M....Thomas S.H.	2018
7	Significant Lactic Acidosis from Albuterol. ( 29849230 )	Hockstein M....Diercks D.	2018
8	Tenofovir Alafenamide Associated Fatal Lactic Acidosis in an Autologous Hematopoietic Stem Cell Transplant Recipient. ( 29975806 )	Alsunaid S.R....Soubani A.O.	2018
9	Letter to the Editor: Diagnosing Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-Like Episodes (MELAS) Requires Not Only Phenotypic But Also Genotypic Verification. ( 29559858 )	Finsterer J....Zarrouk-Mahjoub S.	2018
10	Extending the phenotypic spectrum of Sengers syndrome: Congenital lactic acidosis with synthetic liver dysfunction. ( 29682452 )	Beck D.B....Leon E.	2018
11	Severe lactic acidosis in an extremely low birth weight infant due to thiamine deficiency. ( 29715193 )	Ozdemir H....Ozek E.	2018
12	Intestinal microbial and metabolic alterations following successful fecal microbiota transplant for D-lactic acidosis. ( 29901551 )	Bulik-Sullivan E.C....Gulati A.S.	2018
13	Fatal Case of Metformin-Associated Lactic Acidosis Associated With Temporary Ileostomy: A Case Report. ( 29846279 )	Tirelli F....Persiani R.	2018
14	Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study. ( 29868840 )	Lazarus B....Grams M.E.	2018
15	Defective mitochondrial ATPase due to rare mtDNA m.8969G&gt;A mutation-causing lactic acidosis, intellectual disability, and poor growth. ( 29350304 )	Isohanni P....Suomalainen A.	2018
16	Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes with severe systemic symptoms: Pathology and biochemistry. ( 29480536 )	Kondo H....Murayama K.	2018
17	Pyruvate is a prospective alkalizer to correct hypoxic lactic acidosis. ( 29695298 )	Wang Y....Zhou H.	2018
18	Mammalian Cells Undergo Endoreduplication in Response to Lactic Acidosis. ( 29440645 )	Tan Z....Rancati G.	2018
19	Risk of lactic acidosis in type 2 diabetes patients using metformin: A case control study. ( 29738540 )	Aharaz A....Lassen A.T.	2018
20	Recurrent lactic acidosis and hypoglycemia with inadvertent metformin use: a case of look-alike pills. ( 29340159 )	Jacob T....Goldberg M.D.	2018
21	The Warburg Effect as a Type B Lactic Acidosis in a Patient With Acute Myeloid Leukemia: A Diagnostic Challenge for Clinicians. ( 29974036 )		2018
22	Severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog. ( 29687945 )		2018
23	A urinary biosignature for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS). ( 29471047 )		2018
24	Type B lactic acidosis, an uncommon paraneoplastic syndrome. ( 29293400 )		2018
25	Wolff-Parkinson-White Syndrome in a Patient with Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes Syndrome Mimicking Juvenile Myoclonic Epilepsy. ( 29629547 )		2018
26	Metformin-associated lactic acidosis mimicking ischaemic bowel. ( 29391354 )		2018
27	Persistent Lactic Acidosis: Thinking Outside the Box. ( 29974016 )		2018
28	Hemodialysis in metformin-associated lactic acidosis due to acute overdose in a metformin-naA^ve patient: A case report. ( 29861374 )		2018
29	Conventional and Diffusional Magnetic Resonance Imaging Features of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes in Chinese Patients: A Study of 40 Cases. ( 29369945 )		2018
30	Metformin-Associated Lactic Acidosis: A Case Report. ( 29427160 )		2018
31	Altered Kinetics Properties of Erythrocyte Lactate Dehydrogenase in Type II Diabetic Patients and Its Implications for Lactic Acidosis. ( 29371768 )		2018
32	Zidovudine-induced lactic acidosis with acute pancreatitis and myopathy: Lethal and rare complications. ( 30505059 )	Mahto SK...Singh A	2018
33	Cardiomyopathy associated with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome. ( 30535308 )	Song SK...Lee SH	2018
34	Treatment of Depression With Duloxetine in Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes. ( 29596118 )	Cozart B...Whiting WL	2018
35	Severe type B lactic acidosis and insulin-resistant hyperglycemia related to cadaveric kidney transplantation. ( 29175664 )	Souki FG...Mahmoudi H	2018
36	A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement. ( 30358850 )	Jackson CB...Schaller A	2018
37	Letter in reply to Levine et al. Re: hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( 29536760 )	Bitton JB...Gosselin S	2018
38	Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery. ( 29058235 )	Deden LN...de Boer H	2018
39	Quantitative relationships among plasma lactate, inorganic phosphorus, albumin, unmeasured anions and the anion gap in lactic acidosis. ( 29080515 )	Figge J...Egi M	2018
40	Metformin intoxication: Vasopressin's key role in the management of severe lactic acidosis. ( 29089189 )	Galiero F...Forfori F	2018
41	D-lactic acidosis in humans: systematic literature review. ( 29218437 )	Bianchetti DGAM...Milani GP	2018
42	Comparative analysis of lactic acidosis induced by linezolid and vancomycin therapy using cohort and case-control studies of incidence and associated risk factors. ( 29222713 )	Mori N...Bito S	2018
43	Comparative assessment of probiotics and monensin in the prophylaxis of acute ruminal lactic acidosis in sheep. ( 29316923 )	Reis LF...Ortolani EL	2018
44	Metformin-Induced Lactic Acidosis (MILA): Review of current diagnostic paradigm. ( 29456175 )	Krowl L...Kaul P	2018
45	Pentobarbital-induced lactic acidosis following status epilepticus barbiturate coma. ( 29472424 )	Golden TR...Ghazala S	2018
46	The Case \| Life-threatening lactic acidosis in a patient with jaundice and liver masses. ( 29475549 )	Abdalla H...Bernardo JF	2018
47	Hyperammonemia and lactic acidosis in adults: Differential diagnoses with a focus on inborn errors of metabolism. ( 29497930 )	Tchan M	2018
48	Early linezolid-associated lactic acidosis in a patient with Child's class C liver cirrhosis and end stage renal disease. ( 29503228 )	Cheng CN...Wu CC	2018
49	Determinants of Lactic Acidosis in Acute Cyanide Poisonings. ( 29543597 )	Baud FJ...Carli P	2018
50	Stoned-A Syndrome of D-Lactic Acidosis and Urolithiasis. ( 29570851 )	Berman CM...Merritt RJ	2018

Sources

Genes for Lactic Acidosis

Genes related to Lactic Acidosis (2 elite genes):

(show all 27)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CHAT	Choline O-Acetyltransferase	Protein Coding	407.53	Pathogenic ⁶ GeneCards inferred via : Variants (show sections)
2	KARS	Lysyl-TRNA Synthetase	Protein Coding	403.06	Pathogenic ⁶ DISEASES inferred ¹⁵
3	YARS2	Tyrosyl-TRNA Synthetase 2	Protein Coding	55.24	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
4	ISCU	Iron-Sulfur Cluster Assembly Enzyme	Protein Coding	52.82	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
5	PUS1	Pseudouridine Synthase 1	Protein Coding	50.83	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications Variants (show sections)	15971356 17056637
6	MT-ND1	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 1	Protein Coding	48.39	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications Variants (show sections)	8338207 16492986
7	MT-ND4	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 4	Protein Coding	47.7	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications Variants (show sections)	8338207
8	PDHA1	Pyruvate Dehydrogenase E1 Alpha 1 Subunit	Protein Coding	43.76	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications (show sections)	14635113 7692352 8337946 (more) 9467016 11935326
9	MT-ND5	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 5	Protein Coding	43.03	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Variants (show sections)	19617458 15767514
10	SUCLG1	Succinate-CoA Ligase Alpha Subunit	Protein Coding	42.72	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries (show sections)
11	PC	Pyruvate Carboxylase	Protein Coding	42.59	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications (show sections)	1650287 11928941 16278852 (more) 7720232 9585002
12	LARS2	Leucyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	42.17	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
13	MT-ATP6	Mitochondrially Encoded ATP Synthase Membrane Subunit 6	Protein Coding	41.83	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
14	PNPLA8	Patatin Like Phospholipase Domain Containing 8	Protein Coding	41.7	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Summaries Variants (show sections)
15	PDHX	Pyruvate Dehydrogenase Complex Component X	Protein Coding	41.62	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Summaries (show sections)	9399911 15303005
16	DLD	Dihydrolipoamide Dehydrogenase	Protein Coding	40.04	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications (show sections)	11687750 8652022
17	PDP1	Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 1	Protein Coding	39.61	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications (show sections)	9530159 18197404 12551913 (more) 16981164 15992085 8983728 9501264 16904023 8032855
18	MT-CO3	Mitochondrially Encoded Cytochrome C Oxidase III	Protein Coding	38.1	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Variants (show sections)	12414820
19	MT-CYB	Mitochondrially Encoded Cytochrome B	Protein Coding	33.49	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)
20	POLG	DNA Polymerase Gamma, Catalytic Subunit	Protein Coding	33.42	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	12859329 15373054 18680693 (more) 11508132 15905734 19195941
21	COX14	Cytochrome C Oxidase Assembly Factor COX14	Protein Coding	32.48	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
22	MTO1	Mitochondrial TRNA Translation Optimization 1	Protein Coding	32.47	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
23	RMND1	Required For Meiotic Nuclear Division 1 Homolog	Protein Coding	22.24	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
24	MT-ND6	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6	Protein Coding	22.15	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)
25	GTPBP3	GTP Binding Protein 3, Mitochondrial	Protein Coding	22.05	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
26	DLAT	Dihydrolipoamide S-Acetyltransferase	Protein Coding	21.7	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Summaries (show sections)
27	MT-CO1	Mitochondrially Encoded Cytochrome C Oxidase I	Protein Coding	21.47	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)

Sources

Variations for Lactic Acidosis

ClinVar genetic disease variations for Lactic Acidosis:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	CHAT	NM_020549.4(CHAT): c.1061C> T (p.Thr354Met)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs769234940	GRCh37	Chromosome 10, 50835781: 50835781
2	CHAT	NM_020549.4(CHAT): c.1061C> T (p.Thr354Met)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs769234940	GRCh38	Chromosome 10, 49627735: 49627735
3	CHAT	NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys)	single nucleotide variant	Pathogenic	rs201439531	GRCh37	Chromosome 10, 50872926: 50872926
4	CHAT	NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys)	single nucleotide variant	Pathogenic	rs201439531	GRCh38	Chromosome 10, 49664880: 49664880
5	KARS	NM_001130089.1(KARS): c.1438del (p.Leu480Trpfs)	deletion	Pathogenic		GRCh37	Chromosome 16, 75664391: 75664391
6	KARS	NM_001130089.1(KARS): c.1438del (p.Leu480Trpfs)	deletion	Pathogenic		GRCh38	Chromosome 16, 75630493: 75630493

Sources

Expression for Lactic Acidosis

Search GEO for disease gene expression data for Lactic Acidosis.

Sources

Pathways for Lactic Acidosis

Pathways related to Lactic Acidosis according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁶ Show member pathways Metabolic pathways ³⁷ Metabolism of lipids and lipoproteins ⁶⁶	13.49	CHAT DLD ISCU KARS MT-ATP6 MT-CO3
2	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. ⁶⁶ Show member pathways Alzheimer disease ³⁷ Alzheimers Disease ¹ Complex I biogenesis ⁶⁶ Electron Transport Chain ¹ Formation of ATP by chemiosmotic coupling ⁶⁶ Huntington disease ³⁷ Non-alcoholic fatty liver disease (NAFLD) ³⁷ Oxidative phosphorylation ³⁷ Oxidative phosphorylation ¹ Parkinson disease ³⁷ Respiratory electron transport ⁶⁶ The citric acid (TCA) cycle and respiratory electron transport ⁶⁶ Thermogenesis ³⁷	13.15	DLD MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
3	Glucose metabolism ⁶⁶ Show member pathways gluconeogenesis ¹ Gluconeogenesis ⁶⁶ glycogen biosynthesis ¹ Glycogen breakdown (glycogenolysis) ⁶⁶ Glycogen storage disease type 0 (liver GYS2) ⁶⁶ Glycogen storage disease type II (GAA) ⁶⁶ Glycogen storage disease type IV (GBE1) ⁶⁶ Glycogen synthesis ⁶⁶ glycolysis ¹ Glycolysis ⁶⁶ Glycolysis / Gluconeogenesis ³⁷ Glycolysis and Gluconeogenesis ¹ Glycolysis and gluconeogenesis (short map) ²² Lysosomal glycogen catabolism ⁶⁶ malate-aspartate shuttle ¹	12.38	DLD PC PDHA1 PDHX
4	Carbon metabolism ³⁷ Show member pathways 2-Oxocarboxylic acid metabolism ³⁷ Biosynthesis of amino acids ³⁷ formaldehyde oxidation ¹	12.1	DLD PC PDHA1 SUCLG1
5	Pyruvate metabolism and Citric Acid (TCA) cycle ⁶⁶ Show member pathways Citric acid cycle (TCA cycle) ⁶⁶ Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ⁶⁶ NAD phosphorylation and dephosphorylation ¹ Pyruvate metabolism ⁶⁶ Regulation of pyruvate dehydrogenase (PDH) complex ⁶⁶ TCA Cycle ¹	11.77	DLD PDHA1 PDHX PDP1 SUCLG1
6	Citrate cycle (TCA cycle) ³⁷ Show member pathways pyruvate decarboxylation to acetyl CoA ¹ superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle ¹ TCA cycle ¹ TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) ¹	11.64	DLD PC PDHA1 SUCLG1
7	Signaling by Retinoic Acid ⁶⁶ Show member pathways RA biosynthesis pathway ⁶⁶	11.45	DLD PDHA1 PDHX
8	Pyruvate metabolism ³⁷ Show member pathways methylglyoxal degradation I ¹ methylglyoxal degradation VI ¹	11.2	DLD PC PDHA1
9	Glyoxylate metabolism and glycine degradation ⁶⁶ Show member pathways D-Arginine and D-ornithine metabolism ³⁷ glycine biosynthesis ¹ glycine cleavage ¹ Glycine degradation ⁶⁶ lipoate biosynthesis and incorporation ¹ lipoate salvage ¹ Lipoic acid metabolism ³⁷	11.16	DLD PDHA1 PDHX
10	Amino Acid metabolism ¹	11.06	DLD LARS2 PC PDHA1 PDHX SUCLG1
11	Acetylcholine Synthesis ¹	10.28	CHAT PDHA1

Sources

GO Terms for Lactic Acidosis

Cellular components related to Lactic Acidosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial inner membrane	GO:0005743	9.8	MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4 MT-ND5
2	mitochondrial matrix	GO:0005759	9.7	DLD ISCU KARS LARS2 PC PDHA1
3	respiratory chain	GO:0070469	9.56	MT-CYB MT-ND1 MT-ND4 MT-ND5
4	mitochondrion	GO:0005739	9.55	DLD ISCU KARS LARS2 MT-CO3 MT-CYB
5	mitochondrial respiratory chain complex I	GO:0005747	9.54	MT-ND1 MT-ND4 MT-ND5
6	pyruvate dehydrogenase complex	GO:0045254	9.33	DLD PDHA1 PDHX

Biological processes related to Lactic Acidosis according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidation-reduction process	GO:0055114	9.95	DLD MT-CYB MT-ND1 MT-ND4 MT-ND5 PDHA1
2	aging	GO:0007568	9.73	DLD MT-ATP6 MT-ND4 POLG
3	mitochondrial respiratory chain complex I assembly	GO:0032981	9.67	MT-ND1 MT-ND4 MT-ND5
4	tRNA aminoacylation for protein translation	GO:0006418	9.54	KARS LARS2 YARS2
5	respiratory electron transport chain	GO:0022904	9.51	MT-CO3 MT-CYB
6	ATP synthesis coupled electron transport	GO:0042773	9.46	MT-ND4 MT-ND5
7	aerobic respiration	GO:0009060	9.43	MT-CO3 MT-ND1 MT-ND4
8	acetyl-CoA biosynthetic process from pyruvate	GO:0006086	9.4	DLD PDHA1
9	response to hyperoxia	GO:0055093	9.33	MT-ATP6 MT-CYB POLG
10	electron transport coupled proton transport	GO:0015990	9.32	MT-CYB MT-ND4
11	mitochondrial electron transport, NADH to ubiquinone	GO:0006120	9.26	DLD MT-ND1 MT-ND4 MT-ND5
12	mitochondrial acetyl-CoA biosynthetic process from pyruvate	GO:0061732	8.8	DLD PDHA1 PDHX

Molecular functions related to Lactic Acidosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidoreductase activity	GO:0016491	9.73	DLD MT-CYB MT-ND1 MT-ND4 MT-ND5 PDHA1
2	electron transfer activity	GO:0009055	9.61	DLD MT-CO3 MT-CYB
3	tRNA binding	GO:0000049	9.58	KARS PUS1 YARS2
4	NADH dehydrogenase (ubiquinone) activity	GO:0008137	9.54	MT-ND1 MT-ND4 MT-ND5
5	aminoacyl-tRNA ligase activity	GO:0004812	9.5	KARS LARS2 YARS2
6	ligase activity	GO:0016874	9.35	KARS LARS2 PC SUCLG1 YARS2
7	NADH dehydrogenase activity	GO:0003954	9.33	MT-ND1 MT-ND4 MT-ND5
8	pyruvate dehydrogenase (NAD+) activity	GO:0034604	8.8	DLD PDHA1 PDHX

Sources

Sources for Lactic Acidosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia