MCID: LCT001
MIFTS: 50

Lactic Acidosis

Categories: Metabolic diseases, Rare diseases

Aliases & Classifications for Lactic Acidosis

MalaCards integrated aliases for Lactic Acidosis:

Name: Lactic Acidosis 12 29 6 15
Acidosis, Lactic 44 73
Acidosis Lactic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:3650
ICD10 33 E87.2
MeSH 44 D000140
NCIt 50 C98969
SNOMED-CT 68 91273001
UMLS 73 C0001125

Summaries for Lactic Acidosis

Disease Ontology : 12 A metabolic acidosis characterized by buildup of lactate.

MalaCards based summary : Lactic Acidosis, also known as acidosis, lactic, is related to myopathy, lactic acidosis, and sideroblastic anemia 1 and myopathy, lactic acidosis, and sideroblastic anemia 3. An important gene associated with Lactic Acidosis is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Metformin and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart.

Wikipedia : 76 Lactic acidosis is a medical condition characterized by the buildup of lactate (especially L-lactate) in... more...

Related Diseases for Lactic Acidosis

Diseases in the Lactic Acidosis family:

Lactic Acidosis, Chronic Adult Form Lactic Acidosis Congenital Infantile

Diseases related to Lactic Acidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 281)
# Related Disease Score Top Affiliating Genes
1 myopathy, lactic acidosis, and sideroblastic anemia 1 34.9 PUS1 YARS2
2 myopathy, lactic acidosis, and sideroblastic anemia 3 33.6 MT-ATP6 MT-CO3 MT-ND4
3 pyruvate dehydrogenase e1-alpha deficiency 33.5 PC PDHA1 PDHX
4 myopathy, lactic acidosis, and sideroblastic anemia 32.9 MT-ATP6 MT-CO3 MT-ND4 PUS1 YARS2
5 encephalomyopathy 32.7 MT-CYB MT-ND1 MT-ND4 MT-ND5
6 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 31.7 LARS2 MT-ATP6 MT-CO3 MT-ND1 MT-ND4 MT-ND5
7 sideroblastic anemia 31.1 LARS2 MT-ATP6 PUS1 YARS2
8 optic nerve disease 30.3 MT-ND1 MT-ND4 MT-ND5
9 alpha-ketoglutarate dehydrogenase deficiency 30.3 DLD PDHA1
10 mitochondrial encephalomyopathy 29.8 LARS2 MT-CO3 MT-CYB MT-ND1 MT-ND4 MT-ND5
11 myoclonic epilepsy associated with ragged-red fibers 29.5 MT-ND4 MT-ND5 POLG
12 neuropathy 29.1 MT-ATP6 MT-ND1 MT-ND4 POLG
13 mitochondrial disorders 29.0 MT-ATP6 MT-ND1 MT-ND4 MT-ND5 POLG YARS2
14 mitochondrial myopathy 28.8 MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4 MT-ND5
15 myopathy 27.4 ISCU MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
16 leigh syndrome 27.0 DLD MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
17 mitochondrial myopathy with lactic acidosis 12.6
18 myopathy with lactic acidosis, hereditary 12.6
19 myopathy, lactic acidosis, and sideroblastic anemia 2 12.5
20 hydrops, lactic acidosis, and sideroblastic anemia 12.4
21 encephalopathy, neonatal severe, with lactic acidosis and brain abnormalities 12.4
22 hyperglycinemia, lactic acidosis, and seizures 12.4
23 neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures 12.4
24 lactic acidosis congenital infantile 12.1
25 lactic acidosis, chronic adult form 12.1
26 succinic acidemia lactic acidosis congenital 12.1
27 pyruvate carboxylase deficiency 12.0
28 mitochondrial dna depletion syndrome 9 12.0
29 gracile syndrome 12.0
30 dihydrolipoamide dehydrogenase deficiency 11.9
31 combined oxidative phosphorylation deficiency 10 11.8
32 maple syrup urine disease 11.8
33 leigh syndrome, french canadian type 11.8
34 combined oxidative phosphorylation deficiency 18 11.7
35 mitochondrial phosphate carrier deficiency 11.6
36 combined oxidative phosphorylation deficiency 19 11.6
37 sengers syndrome 11.6
38 pyruvate dehydrogenase phosphatase deficiency 11.4
39 pyruvate dehydrogenase e1-beta deficiency 11.4
40 myopathy with deficiency of iron-sulfur cluster assembly enzyme 11.4
41 combined oxidative phosphorylation deficiency 3 11.4
42 beriberi 11.3
43 mitochondrial complex iv deficiency 11.3
44 mitochondrial complex i deficiency 11.3
45 mitochondrial complex iii deficiency 11.3
46 combined oxidative phosphorylation deficiency 2 11.2
47 mitochondrial complex iii deficiency, nuclear type 6 11.2
48 mitochondrial complex iii deficiency, nuclear type 1 11.1
49 hsd10 mitochondrial disease 11.1
50 barth syndrome 11.1

Graphical network of the top 20 diseases related to Lactic Acidosis:



Diseases related to Lactic Acidosis

Symptoms & Phenotypes for Lactic Acidosis

Drugs & Therapeutics for Lactic Acidosis

Drugs for Lactic Acidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 170)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 657-24-9 14219 4091
2
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
3 Parecoxib Approved Phase 4 198470-84-7
4
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
5
Adefovir Dipivoxil Approved, Investigational Phase 4 142340-99-6 60871
6
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
7
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
8
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
9
Fenoldopam Approved Phase 4 67227-56-9, 67227-57-0 3341
10
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
11
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
13
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
14
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-43-8, 70-16-6 1130
15
Adefovir Investigational Phase 4 106941-25-7
16 Antipsychotic Agents Phase 4
17 Central Nervous System Depressants Phase 4,Not Applicable
18 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Psychotropic Drugs Phase 4
20 Tranquilizing Agents Phase 4
21 Analgesics Phase 4
22 Analgesics, Non-Narcotic Phase 4
23 Analgesics, Opioid Phase 4
24 Anti-Inflammatory Agents Phase 4,Phase 1,Not Applicable
25 Anti-Inflammatory Agents, Non-Steroidal Phase 4
26 Antirheumatic Agents Phase 4
27 Cyclooxygenase 2 Inhibitors Phase 4
28 Cyclooxygenase Inhibitors Phase 4
29 insulin Phase 4,Phase 2
30 Insulin, Globin Zinc Phase 4,Phase 2
31 Narcotics Phase 4
32 Peripheral Nervous System Agents Phase 4,Phase 1,Not Applicable
33 Anti-Infective Agents Phase 4
34 Anti-Retroviral Agents Phase 4
35 Antiviral Agents Phase 4
36 Liver Extracts Phase 4,Not Applicable
37 Nucleic Acid Synthesis Inhibitors Phase 4
38 Reverse Transcriptase Inhibitors Phase 4
39 Vasodilator Agents Phase 4,Phase 1,Phase 2,Not Applicable
40 Dermatologic Agents Phase 4
41 Micronutrients Phase 4,Phase 2,Phase 1
42 Photosensitizing Agents Phase 4
43 Trace Elements Phase 4,Phase 2,Phase 1
44 Vitamin B Complex Phase 4,Phase 1,Phase 2
45 Vitamins Phase 4,Phase 1,Phase 2
46 Antihypertensive Agents Phase 4,Not Applicable
47 Dopamine Agents Phase 4,Not Applicable
48 Dopamine agonists Phase 4
49 Neurotransmitter Agents Phase 4,Not Applicable
50 Vaccines Phase 4

Interventional clinical trials:

(show top 50) (show all 73)
# Name Status NCT ID Phase Drugs
1 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
2 Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery Unknown status NCT01930318 Phase 4 parecoxib
3 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4 Telbivudine;Enecavir;Adefovir
4 Lactate Metabolism Study in HIV Infected Persons Completed NCT00202228 Phase 4 cofactor supplementation (thiamine, riboflavin, L-carnitine)
5 Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass Completed NCT00747331 Phase 4 Fenoldopam mesilate;Placebo
6 Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS) Completed NCT01831934 Phase 4
7 Type 2 Diabetes and Ambulatory Surgery Patients Completed NCT03179254 Phase 4 Metformin continue;Metformin discontinue
8 The Metformin in Coronary Artery Bypass Graft (CABG) (MetCAB) Trial Completed NCT01438723 Phase 4 Metformin;Placebo
9 Body Weight Effects on Glucophage's Efficacy in Chinese Diagnosed T2DM Patients Completed NCT00778622 Phase 4 Metformin XR
10 Lactic Acidosis During Entecavir(ETV)Treatment Terminated NCT01354652 Phase 4 entecavir, lamivudine
11 Metformin Therapy for Overweight Adolescents With Type 1 Diabetes Unknown status NCT01881828 Phase 3 Metformin (glucophage)
12 Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis Completed NCT00004490 Phase 3 sodium dichloroacetate
13 RBC Transfusion in Severe Anemia With Lactic Acidosis Completed NCT01586923 Phase 3
14 Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: Recruiting NCT02616484 Phase 3 Dichloroacetate (DCA)
15 Alcohol: Thiamine and or Magnesium 1 Recruiting NCT03466528 Phase 2, Phase 3 Magnesium Sulfate;Pabrinex
16 Patients With Heart Failure ANd Type 2 Diabetes Treated With Placebo Or Metformin (PHANTOM) Pilot Study Terminated NCT00325910 Phase 3 Metformin
17 Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome Unknown status NCT00068913 Phase 2 Dichloroacetate
18 Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study Unknown status NCT02848508 Phase 2 Metformin
19 Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes Completed NCT00887562 Phase 2 Idebenone;Idebenone
20 Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients Completed NCT01262196 Phase 2 MP4OX;Saline
21 Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients Completed NCT01004198 Phase 2 MP4OX;MP4OX;Ringers Lactate solution
22 Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia Completed NCT00004493 Phase 2 sodium dichloroacetate
23 SELESTIAL: Trial of Insulin to Control Blood Sugar After Acute Stroke Using Magnetic Resonance Imaging (MRI) End-Points Completed NCT00124826 Phase 2 Insulin
24 Thiamine as a Metabolic Resuscitator in Septic Shock Completed NCT01070810 Phase 1, Phase 2 D5W;Thiamine
25 The KHENERGY Study Completed NCT02909400 Phase 2 KH176;placebo
26 Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest Completed NCT01509040 Phase 1, Phase 2
27 Metformin and Simvastatin in Addition to Fulvestrant Recruiting NCT03192293 Phase 2 Metformin/Simvastatin/Fulvestrant
28 Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest Recruiting NCT02974257 Phase 2 Thiamine
29 Metformin for the Minimization of Geographic Atrophy Progression in Patients With AMD Recruiting NCT02684578 Phase 2 Metformin
30 The Effects of Neoadjuvant Metformin on Tumour Cell Proliferation and Tumour Progression in Pancreatic Ductal Adenocarcinoma Not yet recruiting NCT02978547 Phase 2 Metformin Hydrochloride 500Mg Tablet
31 A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease Terminated NCT02473445 Phase 2 Cysteamine Bitartrate
32 Phase 2c Dose Comparison Study of MP4OX in Trauma Withdrawn NCT01973504 Phase 2 MP4OX;Control
33 A Dose-escalating Clinical Trial With KH176 Completed NCT02544217 Phase 1 KH176;placebo
34 A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours Completed NCT00566410 Phase 1 Dichloroacetate
35 Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL) Completed NCT01324180 Phase 1 Metformin;Vincristine;Dexamethasone;PEG-asparaginase;Doxorubicin;Intrathecal chemotherapy
36 Thiamine Supplementation in Patients With Septic Shock Recruiting NCT03122678 Phase 1 Thiamine;Placebos
37 Nitroglycerin Infusion During Cardiac Surgery Unknown status NCT01901419 Not Applicable Nitroglycerin infusion
38 Mitochondrial nt3243 A>G Mutation in Taiwan Unknown status NCT02114554
39 Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital Completed NCT01580111 Not Applicable
40 Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media Completed NCT01873859 Not Applicable Metformin
41 Glucose-insulin-potassium Therapy Improves Lactic Acidosis in Liver Transplantation Completed NCT03522181 Not Applicable
42 Study On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis Completed NCT00942123
43 Metformin Treatment, Renal Function and Lactic Acidosis Completed NCT01358994
44 Lactic Acidosis During and After Seizures Completed NCT01833247
45 Dichloroacetate Kinetics, Metabolism and Toxicology Completed NCT00015015 Dichloroacetate
46 Pharmacotoxicology of Trichloroethylene Metabolites Completed NCT00874276 Not Applicable Dichloroacetate (DCA)
47 Study of Blood Lactate Levels in Patients Treated With Antipsychotics Completed NCT01139463 Haloperidol or olanzapine
48 Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia Completed NCT00004353
49 Prevention of Dichloroacetate Toxicity Completed NCT00031161 Not Applicable Nitisinone (NTBC);Dichloroacetate
50 Effects of Polyphenols Supplementation on Cycling Endurance Completed NCT03214276 Not Applicable

Search NIH Clinical Center for Lactic Acidosis

Cochrane evidence based reviews: acidosis, lactic

Genetic Tests for Lactic Acidosis

Genetic tests related to Lactic Acidosis:

# Genetic test Affiliating Genes
1 Lactic Acidosis 29

Anatomical Context for Lactic Acidosis

MalaCards organs/tissues related to Lactic Acidosis:

41
Kidney, Liver, Heart, B Cells, Testes, Lung, Brain

Publications for Lactic Acidosis

Articles related to Lactic Acidosis:

(show top 50) (show all 850)
# Title Authors Year
1
Multiorgan Failure and Refractory Lactic Acidosis due to <i>Pasteurella multocida</i> Septicemia in a Patient with No Animal Exposure. ( 29765783 )
2018
2
Lactic Acidosis and Asthma Exacerbation. ( 29801682 )
2018
3
Beware of beta! A case of salbutamol-induced lactic acidosis in severe asthma. ( 29914901 )
2018
4
Survival analysis of a cohort of Chinese patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) based on clinical features. ( 29406897 )
2018
5
Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( 29301418 )
2018
6
Significant Lactic Acidosis from Albuterol. ( 29849230 )
2018
7
Tenofovir Alafenamide Associated Fatal Lactic Acidosis in an Autologous Hematopoietic Stem Cell Transplant Recipient. ( 29975806 )
2018
8
Letter to the Editor: Diagnosing Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-Like Episodes (MELAS) Requires Not Only Phenotypic But Also Genotypic Verification. ( 29559858 )
2018
9
Extending the phenotypic spectrum of Sengers syndrome: Congenital lactic acidosis with synthetic liver dysfunction. ( 29682452 )
2018
10
Severe lactic acidosis in an extremely low birth weight infant due to thiamine deficiency. ( 29715193 )
2018
11
Intestinal microbial and metabolic alterations following successful fecal microbiota transplant for D-lactic acidosis. ( 29901551 )
2018
12
Fatal Case of Metformin-Associated Lactic Acidosis Associated With Temporary Ileostomy: A Case Report. ( 29846279 )
2018
13
Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study. ( 29868840 )
2018
14
Defective mitochondrial ATPase due to rare mtDNA m.8969G&amp;gt;A mutation-causing lactic acidosis, intellectual disability, and poor growth. ( 29350304 )
2018
15
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes with severe systemic symptoms: Pathology and biochemistry. ( 29480536 )
2018
16
Pyruvate is a prospective alkalizer to correct hypoxic lactic acidosis. ( 29695298 )
2018
17
Mammalian Cells Undergo Endoreduplication in Response to Lactic Acidosis. ( 29440645 )
2018
18
Risk of lactic acidosis in type 2 diabetes patients using metformin: A case control study. ( 29738540 )
2018
19
Recurrent lactic acidosis and hypoglycemia with inadvertent metformin use: a case of look-alike pills. ( 29340159 )
2018
20
The Warburg Effect as a Type B Lactic Acidosis in a Patient With Acute Myeloid Leukemia: A Diagnostic Challenge for Clinicians. ( 29974036 )
2018
21
Severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog. ( 29687945 )
2018
22
A urinary biosignature for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS). ( 29471047 )
2018
23
Type B lactic acidosis, an uncommon paraneoplastic syndrome. ( 29293400 )
2018
24
Wolff-Parkinson-White Syndrome in a Patient with Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes Syndrome Mimicking Juvenile Myoclonic Epilepsy. ( 29629547 )
2018
25
Metformin-associated lactic acidosis mimicking ischaemic bowel. ( 29391354 )
2018
26
Persistent Lactic Acidosis: Thinking Outside the Box. ( 29974016 )
2018
27
Hemodialysis in metformin-associated lactic acidosis due to acute overdose in a metformin-naA^ve patient: A case report. ( 29861374 )
2018
28
Conventional and Diffusional Magnetic Resonance Imaging Features of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes in Chinese Patients: A Study of 40 Cases. ( 29369945 )
2018
29
Metformin-Associated Lactic Acidosis: A Case Report. ( 29427160 )
2018
30
Altered Kinetics Properties of Erythrocyte Lactate Dehydrogenase in Type II Diabetic Patients and Its Implications for Lactic Acidosis. ( 29371768 )
2018
31
Comparison of magnetic resonance spectroscopy (MRS) with arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic Acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS). ( 29921486 )
2018
32
A case risk study of lactic acidosis risk by metformin use in type 2 diabetes mellitus tuberculosis coinfection patients. ( 29933869 )
2018
33
Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolaviron Correlates with Reduction in Neurobehavioural Deficits. ( 29887685 )
2018
34
Comparative assessment of probiotics and monensin in the prophylaxis of acute ruminal lactic acidosis in sheep. ( 29316923 )
2018
35
Lactate levels and risk of lactic acidosis with metformin in diabetic kidney disease patients. ( 29265047 )
2017
36
Metformin-Associated Lactic Acidosis Undergoing Renal Replacement Therapy in Intensive Care Units: A Five-Million Population-Based Study in the North-West of Italy. ( 28668963 )
2017
37
Uncommon mutation in mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). ( 28242802 )
2017
38
Hemodialysis for Lactic Acidosis. ( 28904487 )
2017
39
Metformin-associated Lactic Acidosis Requiring Intensive Care in a Regional Hospital in Hong Kong and Predictive Factors for Mortality. ( 29307973 )
2017
40
Diabetes mellitus: Complex interplay between metformin, AKI and lactic acidosis. ( 28736433 )
2017
41
Unusual Case of Severe Lactic Acidosis in a Liver Transplant Patient. ( 29391965 )
2017
42
Probiotics, D-Lactic Acidosis, Oxidative Stress and Strain Specificity. ( 28080206 )
2017
43
A case of rhabdomyolysis after status epilepticus without stroke-like episodes in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. ( 28637934 )
2017
44
Adult-onset Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke (MELAS)-like Encephalopathy Diagnosed Based on the Complete Sequencing of Mitochondrial DNA Extracted from Biopsied Muscle without any Myopathic Changes. ( 28050007 )
2017
45
Adult-onset of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome with hypothyroidism and psychiatric disorders. ( 29260009 )
2017
46
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) due to a m.10158T&amp;gt;C ND3 Mutation with a Normal Muscle Biopsy. ( 28883258 )
2017
47
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) due to a m.10158T&amp;gt;C ND3 Mutation with a Normal Muscle Biopsy. ( 28883250 )
2017
48
Gastro-intestinal Involvement in m.3243A&amp;gt;G-associated Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes. ( 29151541 )
2017
49
Lactic acidosis associated (or induced by) metformin. ( 28865920 )
2017
50
Hypoglycemia and severe lactic acidosis in a dog following metformin exposure. ( 29225865 )
2017

Variations for Lactic Acidosis

ClinVar genetic disease variations for Lactic Acidosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh37 Chromosome 10, 50835781: 50835781
2 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh38 Chromosome 10, 49627735: 49627735
3 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh37 Chromosome 10, 50872926: 50872926
4 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh38 Chromosome 10, 49664880: 49664880

Expression for Lactic Acidosis

Search GEO for disease gene expression data for Lactic Acidosis.

Pathways for Lactic Acidosis

Pathways related to Lactic Acidosis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 CHAT DLD ISCU MT-ATP6 MT-CO3 MT-CYB
2
Show member pathways
13.15 DLD MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
3
Show member pathways
12.38 DLD PC PDHA1 PDHX
4
Show member pathways
12.1 DLD PC PDHA1 SUCLG1
5
Show member pathways
11.77 DLD PDHA1 PDHX PDP1 SUCLG1
6
Show member pathways
11.64 DLD PC PDHA1 SUCLG1
7
Show member pathways
11.45 DLD PDHA1 PDHX
8
Show member pathways
11.2 DLD PC PDHA1
9
Show member pathways
11.16 DLD PDHA1 PDHX
10 11.06 DLD LARS2 PC PDHA1 PDHX SUCLG1
11 10.28 CHAT PDHA1

GO Terms for Lactic Acidosis

Cellular components related to Lactic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.8 MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4 MT-ND5
2 mitochondrial matrix GO:0005759 9.65 DLD ISCU LARS2 PC PDHA1 PDHX
3 respiratory chain GO:0070469 9.62 MT-CYB MT-ND1 MT-ND4 MT-ND5
4 mitochondrion GO:0005739 9.55 DLD ISCU LARS2 MT-CO3 MT-CYB MT-ND1
5 mitochondrial respiratory chain complex I GO:0005747 9.54 MT-ND1 MT-ND4 MT-ND5
6 pyruvate dehydrogenase complex GO:0045254 9.33 DLD PDHA1 PDHX

Biological processes related to Lactic Acidosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.99 DLD MT-CYB MT-ND1 MT-ND4 MT-ND5 PDHA1
2 metabolic process GO:0008152 9.93 PC PDHA1 PDHX PNPLA8 SUCLG1
3 aging GO:0007568 9.78 DLD MT-ATP6 MT-ND4 POLG
4 mitochondrial respiratory chain complex I assembly GO:0032981 9.7 MT-ND1 MT-ND4 MT-ND5
5 tricarboxylic acid cycle GO:0006099 9.58 DLD PDHA1 SUCLG1
6 mitochondrial electron transport, NADH to ubiquinone GO:0006120 9.56 DLD MT-ND1 MT-ND4 MT-ND5
7 respiratory electron transport chain GO:0022904 9.55 MT-CO3 MT-CYB
8 cellular nitrogen compound metabolic process GO:0034641 9.54 DLD PDHA1 PDHX
9 response to hyperoxia GO:0055093 9.5 MT-ATP6 MT-CYB POLG
10 ATP synthesis coupled electron transport GO:0042773 9.49 MT-ND4 MT-ND5
11 acetyl-CoA biosynthetic process from pyruvate GO:0006086 9.46 DLD PDHA1
12 electron transport coupled proton transport GO:0015990 9.43 MT-CYB MT-ND4
13 mitochondrial acetyl-CoA biosynthetic process from pyruvate GO:0061732 9.33 DLD PDHA1 PDHX
14 pyruvate metabolic process GO:0006090 9.26 DLD PC PDHA1 PDHX
15 regulation of acetyl-CoA biosynthetic process from pyruvate GO:0010510 8.92 DLD PDHA1 PDHX PDP1

Molecular functions related to Lactic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.73 DLD MT-CYB MT-ND1 MT-ND4 MT-ND5 PDHA1
2 electron transfer activity GO:0009055 9.54 DLD MT-CO3 MT-CYB
3 NADH dehydrogenase (ubiquinone) activity GO:0008137 9.5 MT-ND1 MT-ND4 MT-ND5
4 ligase activity GO:0016874 9.46 LARS2 PC SUCLG1 YARS2
5 NADH dehydrogenase activity GO:0003954 9.13 MT-ND1 MT-ND4 MT-ND5
6 pyruvate dehydrogenase (NAD+) activity GO:0034604 8.8 DLD PDHA1 PDHX

Sources for Lactic Acidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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