MCID: LCT001
MIFTS: 52

Lactic Acidosis

Categories: Metabolic diseases, Rare diseases

Aliases & Classifications for Lactic Acidosis

MalaCards integrated aliases for Lactic Acidosis:

Name: Lactic Acidosis 12 29 6 15
Acidosis, Lactic 44 73
Acidosis Lactic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:3650
ICD10 33 E87.2
MeSH 44 D000140
NCIt 50 C98969
SNOMED-CT 68 91273001
UMLS 73 C0001125

Summaries for Lactic Acidosis

Disease Ontology : 12 A metabolic acidosis characterized by buildup of lactate.

MalaCards based summary : Lactic Acidosis, also known as acidosis, lactic, is related to myopathy, lactic acidosis, and sideroblastic anemia 1 and myopathy, lactic acidosis, and sideroblastic anemia 3. An important gene associated with Lactic Acidosis is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Metformin and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and kidney.

Wikipedia : 76 Lactic acidosis is a medical condition characterized by the buildup of lactate (especially L-lactate) in... more...

Related Diseases for Lactic Acidosis

Diseases in the Lactic Acidosis family:

Lactic Acidosis, Chronic Adult Form Lactic Acidosis Congenital Infantile

Diseases related to Lactic Acidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 317)
# Related Disease Score Top Affiliating Genes
1 myopathy, lactic acidosis, and sideroblastic anemia 1 34.3 PUS1 YARS2
2 myopathy, lactic acidosis, and sideroblastic anemia 3 33.9 MT-ATP6 MT-CO3 MT-ND4
3 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 33.7 LARS2 MT-ATP6 MT-CO3 MT-ND1 MT-ND4 MT-ND5
4 myopathy, lactic acidosis, and sideroblastic anemia 33.6 MT-ATP6 MT-CO3 MT-ND4 PUS1 YARS2
5 pyruvate dehydrogenase e1-alpha deficiency 33.5 PC PDHA1 PDHX
6 mitochondrial myopathy 31.5 ISCU MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
7 leigh syndrome 31.0 DLD MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
8 sideroblastic anemia 30.9 LARS2 MT-ATP6 PUS1 YARS2
9 mitochondrial encephalomyopathy 30.9 LARS2 MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
10 neuropathy 30.1 MT-ATP6 MT-ND1 MT-ND4 MT-ND5 POLG
11 alpha-ketoglutarate dehydrogenase deficiency 30.1 DLD PDHA1
12 myoclonic epilepsy associated with ragged-red fibers 30.0 MT-ND4 MT-ND5 POLG
13 optic nerve disease 29.7 KARS MT-ATP6 MT-ND1 MT-ND4 MT-ND5
14 kearns-sayre syndrome 29.5 MT-ATP6 MT-CYB MT-ND1 MT-ND4 MT-ND5 POLG
15 mitochondrial myopathy with lactic acidosis 12.7
16 myopathy, lactic acidosis, and sideroblastic anemia 2 12.7
17 myopathy with lactic acidosis, hereditary 12.6
18 hydrops, lactic acidosis, and sideroblastic anemia 12.5
19 encephalopathy, neonatal severe, with lactic acidosis and brain abnormalities 12.5
20 neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures 12.5
21 hyperglycinemia, lactic acidosis, and seizures 12.5
22 lactic acidosis congenital infantile 12.3
23 pyruvate carboxylase deficiency 12.2
24 lactic acidosis, chronic adult form 12.2
25 succinic acidemia lactic acidosis congenital 12.2
26 mitochondrial dna depletion syndrome 9 12.2
27 gracile syndrome 12.1
28 dihydrolipoamide dehydrogenase deficiency 12.1
29 combined oxidative phosphorylation deficiency 10 12.0
30 maple syrup urine disease 11.9
31 leigh syndrome, french canadian type 11.9
32 combined oxidative phosphorylation deficiency 18 11.8
33 mitochondrial phosphate carrier deficiency 11.8
34 combined oxidative phosphorylation deficiency 19 11.8
35 sengers syndrome 11.7
36 pyruvate dehydrogenase phosphatase deficiency 11.6
37 pyruvate dehydrogenase e1-beta deficiency 11.6
38 combined oxidative phosphorylation deficiency 3 11.5
39 beriberi 11.5
40 mitochondrial complex iv deficiency 11.4
41 mitochondrial complex i deficiency 11.4
42 lipoyltransferase 1 deficiency 11.4
43 mitochondrial complex iii deficiency 11.4
44 paracetamol poisoning 11.4
45 combined oxidative phosphorylation deficiency 2 11.4
46 mitochondrial complex iii deficiency, nuclear type 6 11.3
47 mitochondrial complex iii deficiency, nuclear type 1 11.2
48 hsd10 mitochondrial disease 11.2
49 barth syndrome 11.2
50 multiple mitochondrial dysfunctions syndrome 1 11.2

Graphical network of the top 20 diseases related to Lactic Acidosis:



Diseases related to Lactic Acidosis

Symptoms & Phenotypes for Lactic Acidosis

Drugs & Therapeutics for Lactic Acidosis

Drugs for Lactic Acidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 187)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 657-24-9 14219 4091
2
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
3
Parecoxib Approved Phase 4 198470-84-7
4
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
5
Adefovir Dipivoxil Approved, Investigational Phase 4 142340-99-6 60871
6
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
7
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
8
Fenoldopam Approved Phase 4 67227-57-0, 67227-56-9 3341
9
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
10
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
11
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59-30-3 6037
13
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-43-8, 70-16-6 1130
14
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
15
Adefovir Investigational Phase 4 106941-25-7
16 Antipsychotic Agents Phase 4
17 Psychotropic Drugs Phase 4
18 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Tranquilizing Agents Phase 4
20 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
21 Anti-Inflammatory Agents, Non-Steroidal Phase 4
22 Analgesics Phase 4,Phase 2,Phase 3
23 insulin Phase 4,Phase 2,Not Applicable
24 Cyclooxygenase 2 Inhibitors Phase 4
25 Analgesics, Opioid Phase 4
26 Narcotics Phase 4
27 Anti-Inflammatory Agents Phase 4,Phase 1,Not Applicable
28 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
29 Antirheumatic Agents Phase 4
30 Cyclooxygenase Inhibitors Phase 4
31 Analgesics, Non-Narcotic Phase 4
32 Insulin, Globin Zinc Phase 4,Phase 2,Not Applicable
33 Antiviral Agents Phase 4
34 Nucleic Acid Synthesis Inhibitors Phase 4
35 Reverse Transcriptase Inhibitors Phase 4
36 Anti-Infective Agents Phase 4
37 Anti-Retroviral Agents Phase 4
38 Liver Extracts Phase 4,Not Applicable
39 Vasodilator Agents Phase 4,Phase 1,Phase 2,Not Applicable
40 Vitamin B Complex Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Photosensitizing Agents Phase 4
42 Vitamins Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Vitamin B2 Phase 4
44 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Vitamin B9 Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
46 Thiamin Phase 4,Phase 2,Phase 3,Phase 1
47 Folate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 carnitine Phase 4
49 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 Dermatologic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 77)
# Name Status NCT ID Phase Drugs
1 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
2 Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery Unknown status NCT01930318 Phase 4 parecoxib
3 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4 Telbivudine;Enecavir;Adefovir
4 Lactate Metabolism Study in HIV Infected Persons Completed NCT00202228 Phase 4 cofactor supplementation (thiamine, riboflavin, L-carnitine)
5 Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass Completed NCT00747331 Phase 4 Fenoldopam mesilate;Placebo
6 Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS) Completed NCT01831934 Phase 4
7 Type 2 Diabetes and Ambulatory Surgery Patients Completed NCT03179254 Phase 4 Metformin continue;Metformin discontinue
8 The Metformin in Coronary Artery Bypass Graft (CABG) (MetCAB) Trial Completed NCT01438723 Phase 4 Metformin;Placebo
9 Body Weight Effects on Glucophage's Efficacy in Chinese Diagnosed T2DM Patients Completed NCT00778622 Phase 4 Metformin XR
10 Lactic Acidosis During Entecavir(ETV)Treatment Terminated NCT01354652 Phase 4 entecavir, lamivudine
11 Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis Completed NCT00004490 Phase 3 sodium dichloroacetate
12 RBC Transfusion in Severe Anemia With Lactic Acidosis Completed NCT01586923 Phase 3
13 Metformin Therapy for Overweight Adolescents With Type 1 Diabetes Completed NCT01881828 Phase 3 Metformin (glucophage)
14 Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: Recruiting NCT02616484 Phase 3 Dichloroacetate (DCA)
15 Alcohol: Thiamine and or Magnesium 1 Recruiting NCT03466528 Phase 2, Phase 3 Magnesium Sulfate;Pabrinex
16 Patients With Heart Failure ANd Type 2 Diabetes Treated With Placebo Or Metformin (PHANTOM) Pilot Study Terminated NCT00325910 Phase 3 Metformin
17 Metformin and Simvastatin in Addition to Fulvestrant Unknown status NCT03192293 Phase 2 Metformin/Simvastatin/Fulvestrant
18 Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome Unknown status NCT00068913 Phase 2 Dichloroacetate
19 Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study Unknown status NCT02848508 Phase 2 Metformin
20 Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes Completed NCT00887562 Phase 2 Idebenone;Idebenone
21 Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients Completed NCT01262196 Phase 2 MP4OX;Saline
22 Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients Completed NCT01004198 Phase 2 MP4OX;MP4OX;Ringers Lactate solution
23 Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia Completed NCT00004493 Phase 2 sodium dichloroacetate
24 SELESTIAL: Trial of Insulin to Control Blood Sugar After Acute Stroke Using Magnetic Resonance Imaging (MRI) End-Points Completed NCT00124826 Phase 2 Insulin
25 Thiamine as a Metabolic Resuscitator in Septic Shock Completed NCT01070810 Phase 1, Phase 2 D5W;Thiamine
26 The KHENERGY Study Completed NCT02909400 Phase 2 KH176;placebo
27 Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest Completed NCT01509040 Phase 1, Phase 2
28 Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest Recruiting NCT02974257 Phase 2 Thiamine
29 Metformin for the Minimization of Geographic Atrophy Progression in Patients With AMD Recruiting NCT02684578 Phase 2 Metformin
30 The Effects of Neoadjuvant Metformin on Tumour Cell Proliferation and Tumour Progression in Pancreatic Ductal Adenocarcinoma Not yet recruiting NCT02978547 Phase 2 Metformin Hydrochloride 500Mg Tablet
31 Insulin Treatment in Diabetic Older People With Heart Failure. Not yet recruiting NCT03665350 Phase 2 Insulin
32 Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study Not yet recruiting NCT03710343 Phase 2 Metformin;Placebo Oral Tablet
33 A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease Terminated NCT02473445 Phase 2 Cysteamine Bitartrate
34 Phase 2c Dose Comparison Study of MP4OX in Trauma Withdrawn NCT01973504 Phase 2 MP4OX;Control
35 A Dose-escalating Clinical Trial With KH176 Completed NCT02544217 Phase 1 KH176;placebo
36 A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours Completed NCT00566410 Phase 1 Dichloroacetate
37 Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL) Completed NCT01324180 Phase 1 Metformin;Vincristine;Dexamethasone;PEG-asparaginase;Doxorubicin;Intrathecal chemotherapy
38 Thiamine Supplementation in Patients With Septic Shock Recruiting NCT03122678 Phase 1 Thiamine;Placebos
39 Nitroglycerin Infusion During Cardiac Surgery Unknown status NCT01901419 Not Applicable Nitroglycerin infusion
40 Mitochondrial nt3243 A>G Mutation in Taiwan Unknown status NCT02114554
41 Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital Completed NCT01580111 Not Applicable
42 Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media Completed NCT01873859 Not Applicable Metformin
43 Glucose-insulin-potassium Therapy Improves Lactic Acidosis in Liver Transplantation Completed NCT03522181 Not Applicable
44 Study On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis Completed NCT00942123
45 Metformin Treatment, Renal Function and Lactic Acidosis Completed NCT01358994
46 Lactic Acidosis During and After Seizures Completed NCT01833247
47 Dichloroacetate Kinetics, Metabolism and Toxicology Completed NCT00015015 Dichloroacetate
48 Pharmacotoxicology of Trichloroethylene Metabolites Completed NCT00874276 Not Applicable Dichloroacetate (DCA)
49 Lactate Acidosis in Postoperative Hearts Completed NCT03025659
50 Study of Blood Lactate Levels in Patients Treated With Antipsychotics Completed NCT01139463 Haloperidol or olanzapine

Search NIH Clinical Center for Lactic Acidosis

Cochrane evidence based reviews: acidosis, lactic

Genetic Tests for Lactic Acidosis

Genetic tests related to Lactic Acidosis:

# Genetic test Affiliating Genes
1 Lactic Acidosis 29

Anatomical Context for Lactic Acidosis

MalaCards organs/tissues related to Lactic Acidosis:

41
Liver, Heart, Kidney, Brain, B Cells, Lung, Prostate

Publications for Lactic Acidosis

Articles related to Lactic Acidosis:

(show top 50) (show all 1213)
# Title Authors Year
1
The Usefulness of Muscle Biopsy in Initial Diagnostic Evaluation of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes. ( 30554496 )
2019
2
Multiorgan Failure and Refractory Lactic Acidosis due to <i>Pasteurella multocida</i> Septicemia in a Patient with No Animal Exposure. ( 29765783 )
2018
3
Lactic Acidosis and Asthma Exacerbation. ( 29801682 )
2018
4
Beware of beta! A case of salbutamol-induced lactic acidosis in severe asthma. ( 29914901 )
2018
5
Survival analysis of a cohort of Chinese patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) based on clinical features. ( 29406897 )
2018
6
Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( 29301418 )
2018
7
Significant Lactic Acidosis from Albuterol. ( 29849230 )
2018
8
Tenofovir Alafenamide Associated Fatal Lactic Acidosis in an Autologous Hematopoietic Stem Cell Transplant Recipient. ( 29975806 )
2018
9
Letter to the Editor: Diagnosing Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-Like Episodes (MELAS) Requires Not Only Phenotypic But Also Genotypic Verification. ( 29559858 )
2018
10
Extending the phenotypic spectrum of Sengers syndrome: Congenital lactic acidosis with synthetic liver dysfunction. ( 29682452 )
2018
11
Severe lactic acidosis in an extremely low birth weight infant due to thiamine deficiency. ( 29715193 )
2018
12
Intestinal microbial and metabolic alterations following successful fecal microbiota transplant for D-lactic acidosis. ( 29901551 )
2018
13
Fatal Case of Metformin-Associated Lactic Acidosis Associated With Temporary Ileostomy: A Case Report. ( 29846279 )
2018
14
Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study. ( 29868840 )
2018
15
Defective mitochondrial ATPase due to rare mtDNA m.8969G&amp;gt;A mutation-causing lactic acidosis, intellectual disability, and poor growth. ( 29350304 )
2018
16
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes with severe systemic symptoms: Pathology and biochemistry. ( 29480536 )
2018
17
Pyruvate is a prospective alkalizer to correct hypoxic lactic acidosis. ( 29695298 )
2018
18
Mammalian Cells Undergo Endoreduplication in Response to Lactic Acidosis. ( 29440645 )
2018
19
Risk of lactic acidosis in type 2 diabetes patients using metformin: A case control study. ( 29738540 )
2018
20
Recurrent lactic acidosis and hypoglycemia with inadvertent metformin use: a case of look-alike pills. ( 29340159 )
2018
21
The Warburg Effect as a Type B Lactic Acidosis in a Patient With Acute Myeloid Leukemia: A Diagnostic Challenge for Clinicians. ( 29974036 )
2018
22
Severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog. ( 29687945 )
2018
23
A urinary biosignature for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS). ( 29471047 )
2018
24
Type B lactic acidosis, an uncommon paraneoplastic syndrome. ( 29293400 )
2018
25
Wolff-Parkinson-White Syndrome in a Patient with Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes Syndrome Mimicking Juvenile Myoclonic Epilepsy. ( 29629547 )
2018
26
Metformin-associated lactic acidosis mimicking ischaemic bowel. ( 29391354 )
2018
27
Persistent Lactic Acidosis: Thinking Outside the Box. ( 29974016 )
2018
28
Hemodialysis in metformin-associated lactic acidosis due to acute overdose in a metformin-naA^ve patient: A case report. ( 29861374 )
2018
29
Conventional and Diffusional Magnetic Resonance Imaging Features of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes in Chinese Patients: A Study of 40 Cases. ( 29369945 )
2018
30
Metformin-Associated Lactic Acidosis: A Case Report. ( 29427160 )
2018
31
Altered Kinetics Properties of Erythrocyte Lactate Dehydrogenase in Type II Diabetic Patients and Its Implications for Lactic Acidosis. ( 29371768 )
2018
32
Zidovudine-induced lactic acidosis with acute pancreatitis and myopathy: Lethal and rare complications. ( 30505059 )
2018
33
Cardiomyopathy associated with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome. ( 30535308 )
2018
34
Treatment of Depression With Duloxetine in Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes. ( 29596118 )
2018
35
Severe type B lactic acidosis and insulin-resistant hyperglycemia related to cadaveric kidney transplantation. ( 29175664 )
2018
36
A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement. ( 30358850 )
2018
37
Letter in reply to Levine et al. Re: hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( 29536760 )
2018
38
Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery. ( 29058235 )
2018
39
Quantitative relationships among plasma lactate, inorganic phosphorus, albumin, unmeasured anions and the anion gap in lactic acidosis. ( 29080515 )
2018
40
Metformin intoxication: Vasopressin's key role in the management of severe lactic acidosis. ( 29089189 )
2018
41
D-lactic acidosis in humans: systematic literature review. ( 29218437 )
2018
42
Comparative analysis of lactic acidosis induced by linezolid and vancomycin therapy using cohort and case-control studies of incidence and associated risk factors. ( 29222713 )
2018
43
Comparative assessment of probiotics and monensin in the prophylaxis of acute ruminal lactic acidosis in sheep. ( 29316923 )
2018
44
Metformin-Induced Lactic Acidosis (MILA): Review of current diagnostic paradigm. ( 29456175 )
2018
45
Pentobarbital-induced lactic acidosis following status epilepticus barbiturate coma. ( 29472424 )
2018
46
The Case | Life-threatening lactic acidosis in a patient with jaundice and liver masses. ( 29475549 )
2018
47
Hyperammonemia and lactic acidosis in adults: Differential diagnoses with a focus on inborn errors of metabolism. ( 29497930 )
2018
48
Early linezolid-associated lactic acidosis in a patient with Child's class C liver cirrhosis and end stage renal disease. ( 29503228 )
2018
49
Determinants of Lactic Acidosis in Acute Cyanide Poisonings. ( 29543597 )
2018
50
Stoned-A Syndrome of D-Lactic Acidosis and Urolithiasis. ( 29570851 )
2018

Variations for Lactic Acidosis

ClinVar genetic disease variations for Lactic Acidosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh37 Chromosome 10, 50835781: 50835781
2 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh38 Chromosome 10, 49627735: 49627735
3 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh37 Chromosome 10, 50872926: 50872926
4 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh38 Chromosome 10, 49664880: 49664880
5 KARS NM_001130089.1(KARS): c.1438del (p.Leu480Trpfs) deletion Pathogenic GRCh37 Chromosome 16, 75664391: 75664391
6 KARS NM_001130089.1(KARS): c.1438del (p.Leu480Trpfs) deletion Pathogenic GRCh38 Chromosome 16, 75630493: 75630493

Expression for Lactic Acidosis

Search GEO for disease gene expression data for Lactic Acidosis.

Pathways for Lactic Acidosis

Pathways related to Lactic Acidosis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 CHAT DLD ISCU KARS MT-ATP6 MT-CO3
2
Show member pathways
13.15 DLD MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
3
Show member pathways
12.38 DLD PC PDHA1 PDHX
4
Show member pathways
12.1 DLD PC PDHA1 SUCLG1
5
Show member pathways
11.77 DLD PDHA1 PDHX PDP1 SUCLG1
6
Show member pathways
11.64 DLD PC PDHA1 SUCLG1
7
Show member pathways
11.45 DLD PDHA1 PDHX
8
Show member pathways
11.2 DLD PC PDHA1
9
Show member pathways
11.16 DLD PDHA1 PDHX
10 11.06 DLD LARS2 PC PDHA1 PDHX SUCLG1
11 10.28 CHAT PDHA1

GO Terms for Lactic Acidosis

Cellular components related to Lactic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.8 MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4 MT-ND5
2 mitochondrial matrix GO:0005759 9.7 DLD ISCU KARS LARS2 PC PDHA1
3 respiratory chain GO:0070469 9.56 MT-CYB MT-ND1 MT-ND4 MT-ND5
4 mitochondrion GO:0005739 9.55 DLD ISCU KARS LARS2 MT-CO3 MT-CYB
5 mitochondrial respiratory chain complex I GO:0005747 9.54 MT-ND1 MT-ND4 MT-ND5
6 pyruvate dehydrogenase complex GO:0045254 9.33 DLD PDHA1 PDHX

Biological processes related to Lactic Acidosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.95 DLD MT-CYB MT-ND1 MT-ND4 MT-ND5 PDHA1
2 aging GO:0007568 9.73 DLD MT-ATP6 MT-ND4 POLG
3 mitochondrial respiratory chain complex I assembly GO:0032981 9.67 MT-ND1 MT-ND4 MT-ND5
4 tRNA aminoacylation for protein translation GO:0006418 9.54 KARS LARS2 YARS2
5 respiratory electron transport chain GO:0022904 9.51 MT-CO3 MT-CYB
6 ATP synthesis coupled electron transport GO:0042773 9.46 MT-ND4 MT-ND5
7 aerobic respiration GO:0009060 9.43 MT-CO3 MT-ND1 MT-ND4
8 acetyl-CoA biosynthetic process from pyruvate GO:0006086 9.4 DLD PDHA1
9 response to hyperoxia GO:0055093 9.33 MT-ATP6 MT-CYB POLG
10 electron transport coupled proton transport GO:0015990 9.32 MT-CYB MT-ND4
11 mitochondrial electron transport, NADH to ubiquinone GO:0006120 9.26 DLD MT-ND1 MT-ND4 MT-ND5
12 mitochondrial acetyl-CoA biosynthetic process from pyruvate GO:0061732 8.8 DLD PDHA1 PDHX

Molecular functions related to Lactic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.73 DLD MT-CYB MT-ND1 MT-ND4 MT-ND5 PDHA1
2 electron transfer activity GO:0009055 9.61 DLD MT-CO3 MT-CYB
3 tRNA binding GO:0000049 9.58 KARS PUS1 YARS2
4 NADH dehydrogenase (ubiquinone) activity GO:0008137 9.54 MT-ND1 MT-ND4 MT-ND5
5 aminoacyl-tRNA ligase activity GO:0004812 9.5 KARS LARS2 YARS2
6 ligase activity GO:0016874 9.35 KARS LARS2 PC SUCLG1 YARS2
7 NADH dehydrogenase activity GO:0003954 9.33 MT-ND1 MT-ND4 MT-ND5
8 pyruvate dehydrogenase (NAD+) activity GO:0034604 8.8 DLD PDHA1 PDHX

Sources for Lactic Acidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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