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MCID: LCT001
MIFTS: 52

Lactic Acidosis

Categories: Metabolic diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Lactic Acidosis

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MalaCards integrated aliases for Lactic Acidosis:

Name: Lactic Acidosis 12 30 6 15 17
Acidosis, Lactic 45 74
Acidosis Lactic 56

Classifications:

MalaCards categories:
Global: Metabolic diseases Rare diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:3650
MeSH 45 D000140
NCIt 51 C98969
SNOMED-CT 69 91273001
ICD10 34 E87.2
UMLS 74 C0001125
Sources

Summaries for Lactic Acidosis

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Disease Ontology : 12 A metabolic acidosis characterized by buildup of lactate.

MalaCards based summary : Lactic Acidosis, also known as acidosis, lactic, is related to myopathy, lactic acidosis, and sideroblastic anemia 1 and myopathy, lactic acidosis, and sideroblastic anemia 3. An important gene associated with Lactic Acidosis is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Metformin and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and heart.

Wikipedia : 77 Lactic acidosis is a medical condition characterized by the buildup of lactate (especially L-lactate) in... more...

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Related Diseases for Lactic Acidosis

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Diseases in the Lactic Acidosis family:

Lactic Acidosis, Chronic Adult Form Lactic Acidosis Congenital Infantile

Diseases related to Lactic Acidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 367)
# Related Disease Score Top Affiliating Genes
1 myopathy, lactic acidosis, and sideroblastic anemia 1 34.8 PUS1 YARS2
2 myopathy, lactic acidosis, and sideroblastic anemia 3 34.3 MT-ATP6 MT-CO3 MT-ND4
3 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 34.2 LARS2 MT-ATP6 MT-CO3 MT-ND1 MT-ND4 MT-ND5
4 myopathy, lactic acidosis, and sideroblastic anemia 33.8 MT-ATP6 MT-CO3 MT-ND4 PUS1 YARS2
5 pyruvate dehydrogenase e1-alpha deficiency 33.8 PC PDHA1 PDHX
6 leigh syndrome 31.4 DLD MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
7 sideroblastic anemia 31.2 LARS2 MT-ATP6 PUS1 YARS2
8 mitochondrial encephalomyopathy 31.0 LARS2 MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
9 mitochondrial myopathy 30.9 ISCU MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
10 neuropathy 30.8 MT-ATP6 MT-ND1 MT-ND4 MT-ND5
11 kearns-sayre syndrome 30.4 MT-ATP6 MT-CYB MT-ND1 MT-ND4 MT-ND5
12 pyruvate dehydrogenase e3-binding protein deficiency 30.4 DLD PDHA1 PDHX
13 alpha-ketoglutarate dehydrogenase deficiency 30.2 DLD PDHA1
14 optic nerve disease 29.8 KARS MT-ATP6 MT-ND1 MT-ND4 MT-ND5
15 mitochondrial myopathy with lactic acidosis 12.8
16 myopathy with lactic acidosis, hereditary 12.8
17 mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes 12.7
18 myopathy, lactic acidosis, and sideroblastic anemia 2 12.7
19 hydrops, lactic acidosis, and sideroblastic anemia 12.7
20 encephalopathy, neonatal severe, with lactic acidosis and brain abnormalities 12.6
21 neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures 12.6
22 hyperglycinemia, lactic acidosis, and seizures 12.6
23 dihydrolipoamide dehydrogenase deficiency 12.3
24 lactic acidosis congenital infantile 12.3
25 pyruvate carboxylase deficiency 12.3
26 lactic acidosis, chronic adult form 12.2
27 succinic acidemia lactic acidosis congenital 12.2
28 mitochondrial dna depletion syndrome 9 12.2
29 gracile syndrome 12.2
30 combined oxidative phosphorylation deficiency 10 12.2
31 maple syrup urine disease 12.0
32 leigh syndrome, french canadian type 11.9
33 combined oxidative phosphorylation deficiency 18 11.9
34 mitochondrial phosphate carrier deficiency 11.8
35 combined oxidative phosphorylation deficiency 19 11.8
36 sengers syndrome 11.8
37 pyruvate dehydrogenase e1-beta deficiency 11.6
38 pyruvate dehydrogenase phosphatase deficiency 11.6
39 combined oxidative phosphorylation deficiency 11 11.6
40 combined oxidative phosphorylation deficiency 23 11.6
41 combined oxidative phosphorylation deficiency 3 11.6
42 beriberi 11.5
43 mitochondrial complex iv deficiency 11.5
44 mitochondrial complex i deficiency, nuclear type 1 11.5
45 mitochondrial complex iii deficiency 11.5
46 lipoyltransferase 1 deficiency 11.4
47 combined oxidative phosphorylation deficiency 26 11.4
48 paracetamol poisoning 11.4
49 combined oxidative phosphorylation deficiency 2 11.4
50 mitochondrial complex iii deficiency, nuclear type 6 11.4

Graphical network of the top 20 diseases related to Lactic Acidosis:



Diseases related to Lactic Acidosis
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Symptoms & Phenotypes for Lactic Acidosis

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Drugs & Therapeutics for Lactic Acidosis

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Drugs for Lactic Acidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 175)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 657-24-9 14219 4091
2
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
3
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
4
Parecoxib Approved Phase 4 198470-84-7
5
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
6
Adefovir dipivoxil Approved, Investigational Phase 4 142340-99-6 60871
7
Stavudine Approved, Investigational Phase 4,Phase 2,Phase 3 3056-17-5 18283
8
Fenoldopam Approved Phase 4 67227-56-9, 67227-57-0 3341
9
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
10
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
11
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
12
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 70-16-6, 59-43-8 1130
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59-30-3 6037
14
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 83-88-5 493570
15
Adefovir Investigational Phase 4 106941-25-7
16 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Tranquilizing Agents Phase 4
18 Psychotropic Drugs Phase 4
19 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
20 Antipsychotic Agents Phase 4
21 Narcotics Phase 4
22 Analgesics Phase 4,Phase 2,Phase 3
23 Antirheumatic Agents Phase 4
24 Cyclooxygenase 2 Inhibitors Phase 4
25 Anti-Inflammatory Agents Phase 4,Phase 1,Not Applicable
26 Insulin, Globin Zinc Phase 4,Phase 2,Not Applicable
27 Analgesics, Opioid Phase 4
28 Anti-Inflammatory Agents, Non-Steroidal Phase 4
29 Analgesics, Non-Narcotic Phase 4
30 insulin Phase 4,Phase 2,Not Applicable
31 Cyclooxygenase Inhibitors Phase 4
32 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
33 Liver Extracts Phase 4,Not Applicable
34 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
35 Anti-Retroviral Agents Phase 4,Phase 2,Phase 3,Not Applicable
36 Antiviral Agents Phase 4,Phase 2,Phase 3,Not Applicable
37 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
38 Reverse Transcriptase Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
39 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
40 Vitamins Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Vitamin B Complex Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Nutrients Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Folate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Vitamin B9 Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
46 Thiamin Phase 4,Phase 2,Phase 3,Phase 1
47 Vasodilator Agents Phase 4,Phase 1,Phase 2,Not Applicable
48 Photosensitizing Agents Phase 4,Phase 2,Phase 3
49 carnitine Phase 4
50 Dermatologic Agents Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 83)
# Name Status NCT ID Phase Drugs
1 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
2 Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery Unknown status NCT01930318 Phase 4 parecoxib
3 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4 Telbivudine;Enecavir;Adefovir
4 Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery Unknown status NCT01524315 Phase 4 Vitamin B1-ratiopharm;Placebo
5 Lactate Metabolism Study in HIV Infected Persons Completed NCT00202228 Phase 4 cofactor supplementation (thiamine, riboflavin, L-carnitine)
6 Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass Completed NCT00747331 Phase 4 Fenoldopam mesilate;Placebo
7 Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS) Completed NCT01831934 Phase 4
8 Type 2 Diabetes and Ambulatory Surgery Patients Completed NCT03179254 Phase 4 Metformin continue;Metformin discontinue
9 The Metformin in Coronary Artery Bypass Graft (CABG) (MetCAB) Trial Completed NCT01438723 Phase 4 Metformin;Placebo
10 Body Weight Effects on Glucophage's Efficacy in Chinese Diagnosed T2DM Patients Completed NCT00778622 Phase 4 Metformin XR
11 Lactic Acidosis During Entecavir(ETV)Treatment Terminated NCT01354652 Phase 4 entecavir, lamivudine
12 Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis Completed NCT00004490 Phase 3 sodium dichloroacetate
13 RBC Transfusion in Severe Anemia With Lactic Acidosis Completed NCT01586923 Phase 3
14 Metformin Therapy for Overweight Adolescents With Type 1 Diabetes Completed NCT01881828 Phase 3 Metformin (glucophage)
15 D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE) Completed NCT00143702 Phase 2, Phase 3 d4T;Abacavir;Riboflavin and Thiamine (Supplementation)
16 Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: Recruiting NCT02616484 Phase 3 Dichloroacetate (DCA)
17 Alcohol: Thiamine and or Magnesium 1 Recruiting NCT03466528 Phase 2, Phase 3 Magnesium Sulfate;Pabrinex
18 Metformin as RenoProtector of Progressive Kidney Disease Not yet recruiting NCT03831464 Phase 3 Metformin Hydrochloride;Placebo Oral Tablet
19 Patients With Heart Failure ANd Type 2 Diabetes Treated With Placebo Or Metformin (PHANTOM) Pilot Study Terminated NCT00325910 Phase 3 Metformin
20 Metformin and Simvastatin in Addition to Fulvestrant Unknown status NCT03192293 Phase 2 Metformin/Simvastatin/Fulvestrant
21 Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome Unknown status NCT00068913 Phase 2 Dichloroacetate
22 Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study Unknown status NCT02848508 Phase 2 Metformin
23 Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes Completed NCT00887562 Phase 2 Idebenone;Idebenone
24 Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients Completed NCT01262196 Phase 2 MP4OX;Saline
25 Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients Completed NCT01004198 Phase 2 MP4OX;MP4OX;Ringers Lactate solution
26 Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia Completed NCT00004493 Phase 2 sodium dichloroacetate
27 SELESTIAL: Trial of Insulin to Control Blood Sugar After Acute Stroke Using Magnetic Resonance Imaging (MRI) End-Points Completed NCT00124826 Phase 2 Insulin
28 Thiamine as a Metabolic Resuscitator in Septic Shock Completed NCT01070810 Phase 1, Phase 2 D5W;Thiamine
29 The KHENERGY Study Completed NCT02909400 Phase 2 KH176;placebo
30 Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest Completed NCT01509040 Phase 1, Phase 2
31 Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest Recruiting NCT02974257 Phase 2 Thiamine
32 Insulin Treatment in Diabetic Older People With Heart Failure. Recruiting NCT03665350 Phase 2 Insulin
33 Metformin for the Minimization of Geographic Atrophy Progression in Patients With AMD Recruiting NCT02684578 Phase 2 Metformin
34 The Effects of Neoadjuvant Metformin on Tumour Cell Proliferation and Tumour Progression in Pancreatic Ductal Adenocarcinoma Not yet recruiting NCT02978547 Phase 2 Metformin Hydrochloride 500Mg Tablet
35 Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study Not yet recruiting NCT03710343 Phase 2 Metformin;Placebo Oral Tablet
36 A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease Terminated NCT02473445 Phase 2 Cysteamine Bitartrate
37 Phase 2c Dose Comparison Study of MP4OX in Trauma Withdrawn NCT01973504 Phase 2 MP4OX;Control
38 A Dose-escalating Clinical Trial With KH176 Completed NCT02544217 Phase 1 KH176;placebo
39 A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours Completed NCT00566410 Phase 1 Dichloroacetate
40 Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL) Completed NCT01324180 Phase 1 Metformin;Vincristine;Dexamethasone;PEG-asparaginase;Doxorubicin;Intrathecal chemotherapy
41 L-Citrulline Dose Finding Safety Study in MELAS Not yet recruiting NCT03952234 Phase 1 L-Citrulline
42 Thiamine Supplementation in Patients With Septic Shock Withdrawn NCT03122678 Phase 1 Thiamine;Placebos
43 Nitroglycerin Infusion During Cardiac Surgery Unknown status NCT01901419 Not Applicable Nitroglycerin infusion
44 Mitochondrial nt3243 A>G Mutation in Taiwan Unknown status NCT02114554
45 Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital Completed NCT01580111 Not Applicable
46 Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media Completed NCT01873859 Not Applicable Metformin
47 Glucose-insulin-potassium Therapy Improves Lactic Acidosis in Liver Transplantation Completed NCT03522181 Not Applicable
48 Study On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis Completed NCT00942123
49 Metformin Treatment, Renal Function and Lactic Acidosis Completed NCT01358994
50 Lactic Acidosis During and After Seizures Completed NCT01833247

Search NIH Clinical Center for Lactic Acidosis

Cochrane evidence based reviews: acidosis, lactic

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Genetic Tests for Lactic Acidosis

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Genetic tests related to Lactic Acidosis:

# Genetic test Affiliating Genes
1 Lactic Acidosis 30
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Anatomical Context for Lactic Acidosis

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MalaCards organs/tissues related to Lactic Acidosis:

42
Liver, Kidney, Heart, Brain, Lung, B Cells, Prostate
Sources

Publications for Lactic Acidosis

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Articles related to Lactic Acidosis:

(show top 50) (show all 1934)
# Title Authors Year
1
Late-onset Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes Presenting With Auditory Agnosia. ( 31045719 )
2019
2
Lactic Acidosis and Asthma Exacerbation. ( 29801682 )
2019
3
Lactic acidosis due to metformin in type 2 diabetes mellitus and chronic kidney disease stage 3-5: is it significant? ( 30963454 )
2019
4
Severe and persistent hypoglycemia with lactic acidosis in an elderly lady with type 2 diabetes mellitus and lymphoma∖leukemia: A rare case report. ( 30641783 )
2019
5
Severe Encephalopathy, Lactic Acidosis and Hyperammonaemia With FOLFIRI Plus Aflibercept After Two-stage Hepatectomy: A Case Report. ( 30804142 )
2019
6
Chorea-ballism as a dominant clinical manifestation in heteroplasmic mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes syndrome with A3251G mutation in mitochondrial genome: a case report. ( 30837005 )
2019
7
Focal cerebellar infarction as an initial sign of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. ( 30693531 )
2019
8
Cardiomyopathy associated with mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome. ( 30535308 )
2019
9
A urinary biosignature for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS). ( 29471047 )
2019
10
A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement. ( 30358850 )
2019
11
A patient with solid gynecologic cancer causing lactic acidosis, severe hypercalcemia, and hypoglycemia. ( 30656010 )
2019
12
Gap acidosis except lactic acidosis develops and progresses during chronic kidney disease stage G5. ( 31062197 )
2019
13
Incidence, factors related to presentation, course and mortality of metformin-associated lactic acidosis in the healthcare area of a tertiary hospital. ( 30060893 )
2019
14
The Usefulness of Muscle Biopsy in Initial Diagnostic Evaluation of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes. ( 30554496 )
2019
15
Albuterol-Induced Lactic Acidosis. ( 30664522 )
2019
16
Levetiracetam administration is correlated with lower mortality in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes: a retrospective study. ( 30681492 )
2019
17
White matter connection's damage, not cortical activation, leading to language dysfunction of mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes. ( 30707182 )
2019
18
Congenital lactic acidosis, cerebral cysts and pulmonary hypertension in an infant with FOXRED1 related complex I deficiency. ( 30723688 )
2019
19
Absence of TXNIP in Human Gives Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate. ( 30755400 )
2019
20
Metformin-associated lactic acidosis, a ghost or a murderer? ( 30782389 )
2019
21
Type B Lactic Acidosis: A Rare Initial Presentation of Childhood Acute Lymphoblastic Leukemia. ( 30814800 )
2019
22
Inconsistencies in Reporting Studies of Lactic Acidosis. ( 30830191 )
2019
23
Inconsistencies in Reporting Studies of Lactic Acidosis-Reply. ( 30830196 )
2019
24
Does reduced oxygen delivery cause lactic acidosis in falciparum malaria? An observational study. ( 30909915 )
2019
25
Metformin-associated Severe Lactic Acidosis in the Setting of Acute Kidney Injury. ( 30911453 )
2019
26
Lactic acidosis caused by repressed lactate dehydrogenase subunit B expression down-regulates mitochondrial oxidative phosphorylation via the pyruvate dehydrogenase (PDH)-PDH kinase axis. ( 30923124 )
2019
27
A Challenging Case of Coexisting Type A and Type B Lactic Acidosis: A Case Report. ( 30937242 )
2019
28
Thiamine and Difficulties in Differentiating Type A From B Lactic Acidosis. ( 30985471 )
2019
29
Hypertonic saline solution (NaCl 7.2%) enhances renal excretion of acids in cattle with acute ruminal lactic acidosis. ( 30997766 )
2019
30
Life-threatening lactic acidosis occurring in adults with mitochondrial disorders. ( 31053354 )
2019
31
Congenital lactic acidosis, cerebral cysts and pulmonary hypertension in an infant with FOXRED1 related complex 1 deficiency. ( 31065540 )
2019
32
Zidovudine-induced lactic acidosis with acute pancreatitis and myopathy: Lethal and rare complications. ( 30505059 )
2018
33
Beware of beta! A case of salbutamol-induced lactic acidosis in severe asthma. ( 29914901 )
2018
34
A case risk study of lactic acidosis risk by metformin use in type 2 diabetes mellitus tuberculosis coinfection patients. ( 29933869 )
2018
35
Treatment of Depression With Duloxetine in Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes. ( 29596118 )
2018
36
Wolff-Parkinson-White Syndrome in a Patient with Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes Syndrome Mimicking Juvenile Myoclonic Epilepsy. ( 29629547 )
2018
37
Gastro-intestinal Involvement in m.3243A>G-associated Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes. ( 29151541 )
2018
38
Acute necrotizing esophagitis presenting with severe lactic acidosis and shock. ( 30948978 )
2018
39
Case report: lactic acidosis and rhabdomyolysis during telbivudine and tenofovir treatment for chronic hepatitis B. ( 29625557 )
2018
40
Severe type B lactic acidosis and insulin-resistant hyperglycemia related to cadaveric kidney transplantation. ( 29175664 )
2018
41
Letter in reply to Levine et al. Re: hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( 29536760 )
2018
42
Severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog. ( 29687945 )
2018
43
Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( 29301418 )
2018
44
Recurrent lactic acidosis and hypoglycemia with inadvertent metformin use: a case of look-alike pills. ( 29340159 )
2018
45
Linezolid-Induced Lactic Acidosis Sets Stage for Surgery to Rule Out Mesenteric Ischemia: A Case Report. ( 29634533 )
2018
46
Determinants of Lactic Acidosis in Acute Cyanide Poisonings. ( 29543597 )
2018
47
Letter to the Editor: Diagnosing Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-Like Episodes (MELAS) Requires Not Only Phenotypic But Also Genotypic Verification. ( 29559858 )
2018
48
Stoned-A Syndrome of D-Lactic Acidosis and Urolithiasis. ( 29570851 )
2018
49
Range of therapeutic metformin concentrations in clinical blood samples and comparison to a forensic case with death due to lactic acidosis. ( 29574345 )
2018
50
Persistent Profound Lactic Acidosis: an Unusual Case. ( 29581080 )
2018
Sources

Variations for Lactic Acidosis

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ClinVar genetic disease variations for Lactic Acidosis:

6 (show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh37 Chromosome 10, 50835781: 50835781
2 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh38 Chromosome 10, 49627735: 49627735
3 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh37 Chromosome 10, 50872926: 50872926
4 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh38 Chromosome 10, 49664880: 49664880
5 KARS NM_001130089.1(KARS): c.1438del (p.Leu480Trpfs) deletion Pathogenic GRCh37 Chromosome 16, 75664391: 75664391
6 KARS NM_001130089.1(KARS): c.1438del (p.Leu480Trpfs) deletion Pathogenic GRCh38 Chromosome 16, 75630493: 75630493
7 UQCRFS1 NM_006003.3(UQCRFS1): c.215-1G> C single nucleotide variant Pathogenic GRCh37 Chromosome 19, 29699066: 29699066
8 UQCRFS1 NM_006003.3(UQCRFS1): c.215-1G> C single nucleotide variant Pathogenic GRCh38 Chromosome 19, 29208159: 29208159
9 UQCRFS1 NM_006003.3(UQCRFS1): c.610C> T (p.Arg204Ter) single nucleotide variant Pathogenic GRCh38 Chromosome 19, 29207763: 29207763
10 UQCRFS1 NM_006003.3(UQCRFS1): c.610C> T (p.Arg204Ter) single nucleotide variant Pathogenic GRCh37 Chromosome 19, 29698670: 29698670
11 UQCRFS1 NM_006003.3(UQCRFS1): c.41T> A (p.Val14Asp) single nucleotide variant Pathogenic GRCh38 Chromosome 19, 29213078: 29213078
12 UQCRFS1 NM_006003.3(UQCRFS1): c.41T> A (p.Val14Asp) single nucleotide variant Pathogenic GRCh37 Chromosome 19, 29703985: 29703985
Sources

Expression for Lactic Acidosis

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Search GEO for disease gene expression data for Lactic Acidosis.
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Pathways for Lactic Acidosis

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Pathways related to Lactic Acidosis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Metabolism 67
Show member pathways
 13.2 CHAT DLD ISCU KARS MT-ATP6 MT-CO3
2
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 67
Show member pathways
 13.19 DLD MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
3
Glucose metabolism 67
Show member pathways
 12.39 DLD PC PDHA1 PDHX
4
Carbon metabolism 38
Show member pathways
 12.1 DLD PC PDHA1 SUCLG1
5
Pyruvate metabolism and Citric Acid (TCA) cycle 67
Show member pathways
 11.77 DLD PDHA1 PDHX PDP1 SUCLG1
6
Citrate cycle (TCA cycle) 38
Show member pathways
 11.64 DLD PC PDHA1 SUCLG1
7
Cardiac muscle contraction 38
11.56 MT-CO3 MT-CYB UQCRFS1
8
Signaling by Retinoic Acid 67
Show member pathways
 11.45 DLD PDHA1 PDHX
9
Amino Acid metabolism 1
11.39 DLD LARS2 PC PDHA1 PDHX SUCLG1
10
Pyruvate metabolism 38
Show member pathways
 11.2 DLD PC PDHA1
11
Glyoxylate metabolism and glycine degradation 67
Show member pathways
 11.16 DLD PDHA1 PDHX
12
Propanoate metabolism 38
11.03 DLD SUCLG1
13
Acetylcholine Synthesis 1
10.28 CHAT PDHA1
Sources

GO Terms for Lactic Acidosis

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Cellular components related to Lactic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.87 MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4 MT-ND5
2 mitochondrial matrix GO:0005759 9.7 DLD ISCU KARS LARS2 PC PDHA1
3 respiratory chain GO:0070469 9.55 MT-CYB MT-ND1 MT-ND4 MT-ND5 UQCRFS1
4 mitochondrion GO:0005739 9.55 DLD ISCU KARS LARS2 MT-CO3 MT-CYB
5 mitochondrial respiratory chain complex I GO:0005747 9.54 MT-ND1 MT-ND4 MT-ND5
6 mitochondrial membrane GO:0031966 9.46 MT-ND1 MT-ND4
7 pyruvate dehydrogenase complex GO:0045254 9.43 DLD PDHA1 PDHX
8 mitochondrial respiratory chain complex III GO:0005750 9.4 MT-CYB UQCRFS1
9 mitochondrial respiratory chain complex IV GO:0005751 9.13 UQCRFS1

Biological processes related to Lactic Acidosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.7 DLD MT-CYB MT-ND1 MT-ND4 MT-ND5 PDHA1
2 mitochondrial respiratory chain complex I assembly GO:0032981 9.63 MT-ND1 MT-ND4 MT-ND5
3 tRNA aminoacylation for protein translation GO:0006418 9.54 KARS LARS2 YARS2
4 respiratory electron transport chain GO:0022904 9.51 MT-CO3 MT-CYB
5 mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 9.49 MT-CYB UQCRFS1
6 response to hyperoxia GO:0055093 9.48 MT-ATP6 MT-CYB
7 ATP synthesis coupled electron transport GO:0042773 9.43 MT-ND4 MT-ND5
8 aerobic respiration GO:0009060 9.43 MT-CO3 MT-ND1 MT-ND4
9 acetyl-CoA biosynthetic process from pyruvate GO:0006086 9.4 DLD PDHA1
10 electron transport coupled proton transport GO:0015990 9.32 MT-CYB MT-ND4
11 mitochondrial electron transport, NADH to ubiquinone GO:0006120 9.26 DLD MT-ND1 MT-ND4 MT-ND5
12 mitochondrial acetyl-CoA biosynthetic process from pyruvate GO:0061732 8.8 DLD PDHA1 PDHX

Molecular functions related to Lactic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.63 DLD MT-CO3 MT-CYB
2 tRNA binding GO:0000049 9.58 KARS PUS1 YARS2
3 oxidoreductase activity GO:0016491 9.56 DLD MT-CYB PDHA1 UQCRFS1
4 NADH dehydrogenase (ubiquinone) activity GO:0008137 9.54 MT-ND1 MT-ND4 MT-ND5
5 aminoacyl-tRNA ligase activity GO:0004812 9.5 KARS LARS2 YARS2
6 2 iron, 2 sulfur cluster binding GO:0051537 9.48 ISCU UQCRFS1
7 ubiquinol-cytochrome-c reductase activity GO:0008121 9.43 MT-CYB UQCRFS1
8 ligase activity GO:0016874 9.35 KARS LARS2 PC SUCLG1 YARS2
9 NADH dehydrogenase activity GO:0003954 9.33 MT-ND1 MT-ND4 MT-ND5
10 pyruvate dehydrogenase (NAD+) activity GO:0034604 8.8 DLD PDHA1 PDHX
Sources

Sources for Lactic Acidosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
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32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
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70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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