Lactic Acidosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LCT001 MIFTS: 50	Lactic Acidosis Categories: Metabolic diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Download Expand all tables

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Aliases & Classifications for Lactic Acidosis

MalaCards integrated aliases for Lactic Acidosis:

Name: Lactic Acidosis ¹² ²⁹ ⁶ ¹⁵

Acidosis, Lactic ⁴⁴ ⁷³

Acidosis Lactic ⁵⁵

Classifications:

MalaCards categories:
Global: Metabolic diseases Rare diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Endocrine, nutritional and metabolic diseases

Metabolic disorders

Other disorders of fluid, electrolyte and acid-base balance

Acidosis

External Ids:

Disease Ontology ¹² DOID:3650

ICD10 ³³ E87.2

MeSH ⁴⁴ D000140

NCIt ⁵⁰ C98969

SNOMED-CT ⁶⁸ 91273001

UMLS ⁷³ C0001125

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Summaries for Lactic Acidosis

Disease Ontology : ¹² A metabolic acidosis characterized by buildup of lactate.

MalaCards based summary : Lactic Acidosis, also known as acidosis, lactic, is related to myopathy, lactic acidosis, and sideroblastic anemia 1 and myopathy, lactic acidosis, and sideroblastic anemia 3. An important gene associated with Lactic Acidosis is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Metformin and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart.

Wikipedia : ⁷⁶ Lactic acidosis is a medical condition characterized by the buildup of lactate (especially L-lactate) in... more...

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Related Diseases for Lactic Acidosis

Diseases in the Lactic Acidosis family:

Lactic Acidosis, Chronic Adult Form

Lactic Acidosis Congenital Infantile

Diseases related to Lactic Acidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 281)

#	Related Disease	Score	Top Affiliating Genes
1	myopathy, lactic acidosis, and sideroblastic anemia 1	34.9	PUS1 YARS2
2	myopathy, lactic acidosis, and sideroblastic anemia 3	33.6	MT-ATP6 MT-CO3 MT-ND4
3	pyruvate dehydrogenase e1-alpha deficiency	33.5	PC PDHA1 PDHX
4	myopathy, lactic acidosis, and sideroblastic anemia	32.9	MT-ATP6 MT-CO3 MT-ND4 PUS1 YARS2
5	encephalomyopathy	32.7	MT-CYB MT-ND1 MT-ND4 MT-ND5
6	mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	31.7	LARS2 MT-ATP6 MT-CO3 MT-ND1 MT-ND4 MT-ND5
7	sideroblastic anemia	31.1	LARS2 MT-ATP6 PUS1 YARS2
8	optic nerve disease	30.3	MT-ND1 MT-ND4 MT-ND5
9	alpha-ketoglutarate dehydrogenase deficiency	30.3	DLD PDHA1
10	mitochondrial encephalomyopathy	29.8	LARS2 MT-CO3 MT-CYB MT-ND1 MT-ND4 MT-ND5
11	myoclonic epilepsy associated with ragged-red fibers	29.5	MT-ND4 MT-ND5 POLG
12	neuropathy	29.1	MT-ATP6 MT-ND1 MT-ND4 POLG
13	mitochondrial disorders	29.0	MT-ATP6 MT-ND1 MT-ND4 MT-ND5 POLG YARS2
14	mitochondrial myopathy	28.8	MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4 MT-ND5
15	myopathy	27.4	ISCU MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
16	leigh syndrome	27.0	DLD MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
17	mitochondrial myopathy with lactic acidosis	12.6
18	myopathy with lactic acidosis, hereditary	12.6
19	myopathy, lactic acidosis, and sideroblastic anemia 2	12.5
20	hydrops, lactic acidosis, and sideroblastic anemia	12.4
21	encephalopathy, neonatal severe, with lactic acidosis and brain abnormalities	12.4
22	hyperglycinemia, lactic acidosis, and seizures	12.4
23	neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures	12.4
24	lactic acidosis congenital infantile	12.1
25	lactic acidosis, chronic adult form	12.1
26	succinic acidemia lactic acidosis congenital	12.1
27	pyruvate carboxylase deficiency	12.0
28	mitochondrial dna depletion syndrome 9	12.0
29	gracile syndrome	12.0
30	dihydrolipoamide dehydrogenase deficiency	11.9
31	combined oxidative phosphorylation deficiency 10	11.8
32	maple syrup urine disease	11.8
33	leigh syndrome, french canadian type	11.8
34	combined oxidative phosphorylation deficiency 18	11.7
35	mitochondrial phosphate carrier deficiency	11.6
36	combined oxidative phosphorylation deficiency 19	11.6
37	sengers syndrome	11.6
38	pyruvate dehydrogenase phosphatase deficiency	11.4
39	pyruvate dehydrogenase e1-beta deficiency	11.4
40	myopathy with deficiency of iron-sulfur cluster assembly enzyme	11.4
41	combined oxidative phosphorylation deficiency 3	11.4
42	beriberi	11.3
43	mitochondrial complex iv deficiency	11.3
44	mitochondrial complex i deficiency	11.3
45	mitochondrial complex iii deficiency	11.3
46	combined oxidative phosphorylation deficiency 2	11.2
47	mitochondrial complex iii deficiency, nuclear type 6	11.2
48	mitochondrial complex iii deficiency, nuclear type 1	11.1
49	hsd10 mitochondrial disease	11.1
50	barth syndrome	11.1

Graphical network of the top 20 diseases related to Lactic Acidosis:

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Symptoms & Phenotypes for Lactic Acidosis

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Drugs & Therapeutics for Lactic Acidosis

Drugs for Lactic Acidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 170)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Metformin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

657-24-9

14219 4091

Celecoxib

Approved, Investigational

Phase 4

169590-42-5

2662

Parecoxib

Approved

Phase 4

198470-84-7

Tramadol

Approved, Investigational

Phase 4

27203-92-5

33741

Adefovir Dipivoxil

Approved, Investigational

Phase 4

142340-99-6

60871

Telbivudine

Approved, Investigational

Phase 4

3424-98-4

159269

Stavudine

Approved, Investigational

Phase 4

3056-17-5

18283

Dopamine

Approved

Phase 4,Not Applicable

51-61-6, 62-31-7

681

Fenoldopam

Approved

Phase 4

67227-56-9, 67227-57-0

3341

Entecavir

Approved, Investigational

Phase 4

142217-69-4

153941

Lamivudine

Approved, Investigational

Phase 4

134678-17-4

60825

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 1,Phase 2

59-30-3

6037

Riboflavin

Approved, Investigational, Nutraceutical, Vet_approved

Phase 4

83-88-5

493570

Thiamine

Approved, Investigational, Nutraceutical, Vet_approved

Phase 4,Phase 1,Phase 2

59-43-8, 70-16-6

1130

Adefovir

Investigational

Phase 4

106941-25-7

Antipsychotic Agents

Phase 4

Central Nervous System Depressants

Phase 4,Not Applicable

Hypoglycemic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Psychotropic Drugs

Phase 4

Tranquilizing Agents

Phase 4

Analgesics

Phase 4

Analgesics, Non-Narcotic

Phase 4

Analgesics, Opioid

Phase 4

Anti-Inflammatory Agents

Phase 4,Phase 1,Not Applicable

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Antirheumatic Agents

Phase 4

Cyclooxygenase 2 Inhibitors

Phase 4

Cyclooxygenase Inhibitors

Phase 4

insulin

Phase 4,Phase 2

Insulin, Globin Zinc

Phase 4,Phase 2

Narcotics

Phase 4

Peripheral Nervous System Agents

Phase 4,Phase 1,Not Applicable

Anti-Infective Agents

Phase 4

Anti-Retroviral Agents

Phase 4

Antiviral Agents

Phase 4

Liver Extracts

Phase 4,Not Applicable

Nucleic Acid Synthesis Inhibitors

Phase 4

Reverse Transcriptase Inhibitors

Phase 4

Vasodilator Agents

Phase 4,Phase 1,Phase 2,Not Applicable

Dermatologic Agents

Phase 4

Micronutrients

Phase 4,Phase 2,Phase 1

Photosensitizing Agents

Phase 4

Trace Elements

Phase 4,Phase 2,Phase 1

Vitamin B Complex

Phase 4,Phase 1,Phase 2

Vitamins

Phase 4,Phase 1,Phase 2

Antihypertensive Agents

Phase 4,Not Applicable

Dopamine Agents

Phase 4,Not Applicable

Dopamine agonists

Phase 4

Neurotransmitter Agents

Phase 4,Not Applicable

Vaccines

Phase 4

Interventional clinical trials:

(show top 50) (show all 73)

#	Name	Status	NCT ID	Phase	Drugs
1	Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics	Unknown status	NCT00845936	Phase 4	Metformin
2	Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery	Unknown status	NCT01930318	Phase 4	parecoxib
3	Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial	Unknown status	NCT01799486	Phase 4	Telbivudine;Enecavir;Adefovir
4	Lactate Metabolism Study in HIV Infected Persons	Completed	NCT00202228	Phase 4	cofactor supplementation (thiamine, riboflavin, L-carnitine)
5	Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass	Completed	NCT00747331	Phase 4	Fenoldopam mesilate;Placebo
6	Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS)	Completed	NCT01831934	Phase 4
7	Type 2 Diabetes and Ambulatory Surgery Patients	Completed	NCT03179254	Phase 4	Metformin continue;Metformin discontinue
8	The Metformin in Coronary Artery Bypass Graft (CABG) (MetCAB) Trial	Completed	NCT01438723	Phase 4	Metformin;Placebo
9	Body Weight Effects on Glucophage's Efficacy in Chinese Diagnosed T2DM Patients	Completed	NCT00778622	Phase 4	Metformin XR
10	Lactic Acidosis During Entecavir(ETV)Treatment	Terminated	NCT01354652	Phase 4	entecavir, lamivudine
11	Metformin Therapy for Overweight Adolescents With Type 1 Diabetes	Unknown status	NCT01881828	Phase 3	Metformin (glucophage)
12	Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis	Completed	NCT00004490	Phase 3	sodium dichloroacetate
13	RBC Transfusion in Severe Anemia With Lactic Acidosis	Completed	NCT01586923	Phase 3
14	Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:	Recruiting	NCT02616484	Phase 3	Dichloroacetate (DCA)
15	Alcohol: Thiamine and or Magnesium 1	Recruiting	NCT03466528	Phase 2, Phase 3	Magnesium Sulfate;Pabrinex
16	Patients With Heart Failure ANd Type 2 Diabetes Treated With Placebo Or Metformin (PHANTOM) Pilot Study	Terminated	NCT00325910	Phase 3	Metformin
17	Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome	Unknown status	NCT00068913	Phase 2	Dichloroacetate
18	Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study	Unknown status	NCT02848508	Phase 2	Metformin
19	Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes	Completed	NCT00887562	Phase 2	Idebenone;Idebenone
20	Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients	Completed	NCT01262196	Phase 2	MP4OX;Saline
21	Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients	Completed	NCT01004198	Phase 2	MP4OX;MP4OX;Ringers Lactate solution
22	Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia	Completed	NCT00004493	Phase 2	sodium dichloroacetate
23	SELESTIAL: Trial of Insulin to Control Blood Sugar After Acute Stroke Using Magnetic Resonance Imaging (MRI) End-Points	Completed	NCT00124826	Phase 2	Insulin
24	Thiamine as a Metabolic Resuscitator in Septic Shock	Completed	NCT01070810	Phase 1, Phase 2	D5W;Thiamine
25	The KHENERGY Study	Completed	NCT02909400	Phase 2	KH176;placebo
26	Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest	Completed	NCT01509040	Phase 1, Phase 2
27	Metformin and Simvastatin in Addition to Fulvestrant	Recruiting	NCT03192293	Phase 2	Metformin/Simvastatin/Fulvestrant
28	Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest	Recruiting	NCT02974257	Phase 2	Thiamine
29	Metformin for the Minimization of Geographic Atrophy Progression in Patients With AMD	Recruiting	NCT02684578	Phase 2	Metformin
30	The Effects of Neoadjuvant Metformin on Tumour Cell Proliferation and Tumour Progression in Pancreatic Ductal Adenocarcinoma	Not yet recruiting	NCT02978547	Phase 2	Metformin Hydrochloride 500Mg Tablet
31	A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease	Terminated	NCT02473445	Phase 2	Cysteamine Bitartrate
32	Phase 2c Dose Comparison Study of MP4OX in Trauma	Withdrawn	NCT01973504	Phase 2	MP4OX;Control
33	A Dose-escalating Clinical Trial With KH176	Completed	NCT02544217	Phase 1	KH176;placebo
34	A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours	Completed	NCT00566410	Phase 1	Dichloroacetate
35	Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL)	Completed	NCT01324180	Phase 1	Metformin;Vincristine;Dexamethasone;PEG-asparaginase;Doxorubicin;Intrathecal chemotherapy
36	Thiamine Supplementation in Patients With Septic Shock	Recruiting	NCT03122678	Phase 1	Thiamine;Placebos
37	Nitroglycerin Infusion During Cardiac Surgery	Unknown status	NCT01901419	Not Applicable	Nitroglycerin infusion
38	Mitochondrial nt3243 A>G Mutation in Taiwan	Unknown status	NCT02114554
39	Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital	Completed	NCT01580111	Not Applicable
40	Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media	Completed	NCT01873859	Not Applicable	Metformin
41	Glucose-insulin-potassium Therapy Improves Lactic Acidosis in Liver Transplantation	Completed	NCT03522181	Not Applicable
42	Study On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis	Completed	NCT00942123
43	Metformin Treatment, Renal Function and Lactic Acidosis	Completed	NCT01358994
44	Lactic Acidosis During and After Seizures	Completed	NCT01833247
45	Dichloroacetate Kinetics, Metabolism and Toxicology	Completed	NCT00015015		Dichloroacetate
46	Pharmacotoxicology of Trichloroethylene Metabolites	Completed	NCT00874276	Not Applicable	Dichloroacetate (DCA)
47	Study of Blood Lactate Levels in Patients Treated With Antipsychotics	Completed	NCT01139463		Haloperidol or olanzapine
48	Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia	Completed	NCT00004353
49	Prevention of Dichloroacetate Toxicity	Completed	NCT00031161	Not Applicable	Nitisinone (NTBC);Dichloroacetate
50	Effects of Polyphenols Supplementation on Cycling Endurance	Completed	NCT03214276	Not Applicable

Search NIH Clinical Center for Lactic Acidosis

Cochrane evidence based reviews: acidosis, lactic

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Genetic Tests for Lactic Acidosis

Genetic tests related to Lactic Acidosis:

#	Genetic test	Affiliating Genes
1	Lactic Acidosis ²⁹

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Anatomical Context for Lactic Acidosis

MalaCards organs/tissues related to Lactic Acidosis:

⁴¹

Kidney, Liver, Heart, B Cells, Testes, Lung, Brain

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Publications for Lactic Acidosis

Articles related to Lactic Acidosis:

(show top 50) (show all 850)

#	Title	Authors	Year
1	Multiorgan Failure and Refractory Lactic Acidosis due to <i>Pasteurella multocida</i> Septicemia in a Patient with No Animal Exposure. ( 29765783 )	Pena D....Khaja M.	2018
2	Lactic Acidosis and Asthma Exacerbation. ( 29801682 )	MartA-nez-TAcbar M.J....GarcA-a-PachA^n E.	2018
3	Beware of beta! A case of salbutamol-induced lactic acidosis in severe asthma. ( 29914901 )	Sharif Z....Al-Alawi M.	2018
4	Survival analysis of a cohort of Chinese patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) based on clinical features. ( 29406897 )	Zhang Z....Wang Z.	2018
5	Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( 29301418 )	Levine M....Thomas S.H.	2018
6	Significant Lactic Acidosis from Albuterol. ( 29849230 )	Hockstein M....Diercks D.	2018
7	Tenofovir Alafenamide Associated Fatal Lactic Acidosis in an Autologous Hematopoietic Stem Cell Transplant Recipient. ( 29975806 )	Alsunaid S.R....Soubani A.O.	2018
8	Letter to the Editor: Diagnosing Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-Like Episodes (MELAS) Requires Not Only Phenotypic But Also Genotypic Verification. ( 29559858 )	Finsterer J....Zarrouk-Mahjoub S.	2018
9	Extending the phenotypic spectrum of Sengers syndrome: Congenital lactic acidosis with synthetic liver dysfunction. ( 29682452 )	Beck D.B....Leon E.	2018
10	Severe lactic acidosis in an extremely low birth weight infant due to thiamine deficiency. ( 29715193 )	Ozdemir H....Ozek E.	2018
11	Intestinal microbial and metabolic alterations following successful fecal microbiota transplant for D-lactic acidosis. ( 29901551 )	Bulik-Sullivan E.C....Gulati A.S.	2018
12	Fatal Case of Metformin-Associated Lactic Acidosis Associated With Temporary Ileostomy: A Case Report. ( 29846279 )	Tirelli F....Persiani R.	2018
13	Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study. ( 29868840 )	Lazarus B....Grams M.E.	2018
14	Defective mitochondrial ATPase due to rare mtDNA m.8969G&gt;A mutation-causing lactic acidosis, intellectual disability, and poor growth. ( 29350304 )	Isohanni P....Suomalainen A.	2018
15	Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes with severe systemic symptoms: Pathology and biochemistry. ( 29480536 )	Kondo H....Murayama K.	2018
16	Pyruvate is a prospective alkalizer to correct hypoxic lactic acidosis. ( 29695298 )	Wang Y....Zhou H.	2018
17	Mammalian Cells Undergo Endoreduplication in Response to Lactic Acidosis. ( 29440645 )	Tan Z....Rancati G.	2018
18	Risk of lactic acidosis in type 2 diabetes patients using metformin: A case control study. ( 29738540 )	Aharaz A....Lassen A.T.	2018
19	Recurrent lactic acidosis and hypoglycemia with inadvertent metformin use: a case of look-alike pills. ( 29340159 )	Jacob T....Goldberg M.D.	2018
20	The Warburg Effect as a Type B Lactic Acidosis in a Patient With Acute Myeloid Leukemia: A Diagnostic Challenge for Clinicians. ( 29974036 )	Brault C....Maizel J.	2018
21	Severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog. ( 29687945 )	Ueda Y....Borchers A.	2018
22	A urinary biosignature for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS). ( 29471047 )	Esterhuizen K....Louw R.	2018
23	Type B lactic acidosis, an uncommon paraneoplastic syndrome. ( 29293400 )	Wahab A....Barta S.K.	2018
24	Wolff-Parkinson-White Syndrome in a Patient with Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes Syndrome Mimicking Juvenile Myoclonic Epilepsy. ( 29629547 )	Sung J.H....Kim J.B.	2018
25	Metformin-associated lactic acidosis mimicking ischaemic bowel. ( 29391354 )	Ali S....Oud L.	2018
26	Persistent Lactic Acidosis: Thinking Outside the Box. ( 29974016 )	Arif H....Kaura A.	2018
27	Hemodialysis in metformin-associated lactic acidosis due to acute overdose in a metformin-naA^ve patient: A case report. ( 29861374 )	McCabe D.J....Stellpflug S.J.	2018
28	Conventional and Diffusional Magnetic Resonance Imaging Features of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes in Chinese Patients: A Study of 40 Cases. ( 29369945 )	Xu W....Geng D.	2018
29	Metformin-Associated Lactic Acidosis: A Case Report. ( 29427160 )	Umeda T....Summerhill E.	2018
30	Altered Kinetics Properties of Erythrocyte Lactate Dehydrogenase in Type II Diabetic Patients and Its Implications for Lactic Acidosis. ( 29371768 )	Mali A.V....Hegde M.V.	2018
31	Comparison of magnetic resonance spectroscopy (MRS) with arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic Acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS). ( 29921486 )	Li X....Wang H.	2018
32	A case risk study of lactic acidosis risk by metformin use in type 2 diabetes mellitus tuberculosis coinfection patients. ( 29933869 )	Novita B.D....Mertaniasih N.M.	2018
33	Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolaviron Correlates with Reduction in Neurobehavioural Deficits. ( 29887685 )	Akinmoladun A.C....Akindahunsi A.A.	2018
34	Comparative assessment of probiotics and monensin in the prophylaxis of acute ruminal lactic acidosis in sheep. ( 29316923 )	Reis L.F....Ortolani E.L.	2018
35	Lactate levels and risk of lactic acidosis with metformin in diabetic kidney disease patients. ( 29265047 )	Bipi P.K....Mohandas M.K.	2017
36	Metformin-Associated Lactic Acidosis Undergoing Renal Replacement Therapy in Intensive Care Units: A Five-Million Population-Based Study in the North-West of Italy. ( 28668963 )	Mariano F....Cantaluppi V.	2017
37	Uncommon mutation in mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). ( 28242802 )	David J....Elamin M.	2017
38	Hemodialysis for Lactic Acidosis. ( 28904487 )	Karthiraj N....Mani A.K.	2017
39	Metformin-associated Lactic Acidosis Requiring Intensive Care in a Regional Hospital in Hong Kong and Predictive Factors for Mortality. ( 29307973 )	Lun C.T....Lai K.Y.	2017
40	Diabetes mellitus: Complex interplay between metformin, AKI and lactic acidosis. ( 28736433 )	Rhee C.M....Kalantar-Zadeh K.	2017
41	Unusual Case of Severe Lactic Acidosis in a Liver Transplant Patient. ( 29391965 )	Golhar S.Y....Guy S.	2017
42	Probiotics, D-Lactic Acidosis, Oxidative Stress and Strain Specificity. ( 28080206 )	Vitetta L....Hall S.	2017
43	A case of rhabdomyolysis after status epilepticus without stroke-like episodes in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. ( 28637934 )	Yokoyama J....Kira J.I.	2017
44	Adult-onset Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke (MELAS)-like Encephalopathy Diagnosed Based on the Complete Sequencing of Mitochondrial DNA Extracted from Biopsied Muscle without any Myopathic Changes. ( 28050007 )	Mukai M....Takizawa S.	2017
45	Adult-onset of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome with hypothyroidism and psychiatric disorders. ( 29260009 )	Ge Y.X....Wang J.	2017
46	Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) due to a m.10158T&gt;C ND3 Mutation with a Normal Muscle Biopsy. ( 28883258 )	Mukai M....Nagata E.	2017
47	Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) due to a m.10158T&gt;C ND3 Mutation with a Normal Muscle Biopsy. ( 28883250 )	Finsterer J....Zarrouk-Mahjoub S.	2017
48	Gastro-intestinal Involvement in m.3243A&gt;G-associated Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes. ( 29151541 )	Suzuki J....Ito Y.	2017
49	Lactic acidosis associated (or induced by) metformin. ( 28865920 )	Ortiz-Lasa M....PeA+asco MartA-n Y.	2017
50	Hypoglycemia and severe lactic acidosis in a dog following metformin exposure. ( 29225865 )	Barrella N....Simpson S.N.	2017

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Genes for Lactic Acidosis

Genes related to Lactic Acidosis (1 elite genes):

(show all 24)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CHAT	Choline O-Acetyltransferase	Protein Coding	400	Pathogenic ⁶
2	YARS2	Tyrosyl-TRNA Synthetase 2	Protein Coding	54.98	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
3	ISCU	Iron-Sulfur Cluster Assembly Enzyme	Protein Coding	52.58	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
4	PUS1	Pseudouridylate Synthase 1	Protein Coding	50.46	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications Variants (show sections)	15971356 17056637
5	MT-ND1	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 1	Protein Coding	48.28	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications Variants (show sections)	8338207 16492986
6	MT-ND4	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 4	Protein Coding	47.28	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications Variants (show sections)	8338207
7	PDHA1	Pyruvate Dehydrogenase E1 Alpha 1 Subunit	Protein Coding	43.36	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications (show sections)	14635113 7692352 8337946 (more) 9467016 11935326
8	MT-ND5	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 5	Protein Coding	42.62	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Variants (show sections)	19617458 15767514
9	SUCLG1	Succinate-CoA Ligase Alpha Subunit	Protein Coding	42.39	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries (show sections)
10	PC	Pyruvate Carboxylase	Protein Coding	42.24	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications (show sections)	1650287 11928941 16278852 (more) 7720232 9585002
11	LARS2	Leucyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	41.83	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
12	MT-ATP6	Mitochondrially Encoded ATP Synthase Membrane Subunit 6	Protein Coding	41.6	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
13	PNPLA8	Patatin Like Phospholipase Domain Containing 8	Protein Coding	41.37	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Summaries Variants (show sections)
14	PDHX	Pyruvate Dehydrogenase Complex Component X	Protein Coding	41.2	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Summaries (show sections)	9399911 15303005
15	DLD	Dihydrolipoamide Dehydrogenase	Protein Coding	40.1	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications (show sections)	11687750 8652022
16	MT-CO3	Mitochondrially Encoded Cytochrome C Oxidase III	Protein Coding	39.89	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Variants (show sections)	12414820
17	PDP1	Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 1	Protein Coding	39.15	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications (show sections)	9530159 18197404 12551913 (more) 16981164 15992085 8983728 9501264 16904023 8032855
18	MT-CYB	Mitochondrially Encoded Cytochrome B	Protein Coding	33.16	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)
19	POLG	DNA Polymerase Gamma, Catalytic Subunit	Protein Coding	32.91	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	12859329 15373054 18680693 (more) 11508132 15905734 19195941
20	MTO1	Mitochondrial TRNA Translation Optimization 1	Protein Coding	32.04	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
21	COX14	COX14, Cytochrome C Oxidase Assembly Factor	Protein Coding	32.03	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
22	RMND1	Required For Meiotic Nuclear Division 1 Homolog	Protein Coding	21.82	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
23	MT-ND6	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6	Protein Coding	21.71	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)
24	GTPBP3	GTP Binding Protein 3, Mitochondrial	Protein Coding	21.58	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)

Sources

Variations for Lactic Acidosis

ClinVar genetic disease variations for Lactic Acidosis:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	CHAT	NM_020549.4(CHAT): c.1061C> T (p.Thr354Met)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs769234940	GRCh37	Chromosome 10, 50835781: 50835781
2	CHAT	NM_020549.4(CHAT): c.1061C> T (p.Thr354Met)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs769234940	GRCh38	Chromosome 10, 49627735: 49627735
3	CHAT	NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys)	single nucleotide variant	Pathogenic	rs201439531	GRCh37	Chromosome 10, 50872926: 50872926
4	CHAT	NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys)	single nucleotide variant	Pathogenic	rs201439531	GRCh38	Chromosome 10, 49664880: 49664880

Sources

Expression for Lactic Acidosis

Search GEO for disease gene expression data for Lactic Acidosis.

Sources

Pathways for Lactic Acidosis

Pathways related to Lactic Acidosis according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁶ Show member pathways Metabolic pathways ³⁷ Metabolism of lipids and lipoproteins ⁶⁶	13.49	CHAT DLD ISCU MT-ATP6 MT-CO3 MT-CYB
2	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. ⁶⁶ Show member pathways Alzheimer's disease ³⁷ Alzheimers Disease ¹ Complex I biogenesis ⁶⁶ Electron Transport Chain ¹ Formation of ATP by chemiosmotic coupling ⁶⁶ Huntington's disease ³⁷ Non-alcoholic fatty liver disease (NAFLD) ³⁷ Oxidative phosphorylation ³⁷ Oxidative phosphorylation ¹ Parkinson's disease ³⁷ Respiratory electron transport ⁶⁶ The citric acid (TCA) cycle and respiratory electron transport ⁶⁶ Thermogenesis ³⁷	13.15	DLD MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4
3	Glucose metabolism ⁶⁶ Show member pathways gluconeogenesis ¹ Gluconeogenesis ⁶⁶ glycogen biosynthesis ¹ Glycogen breakdown (glycogenolysis) ⁶⁶ Glycogen storage disease type 0 (liver GYS2) ⁶⁶ Glycogen storage disease type II (GAA) ⁶⁶ Glycogen storage disease type IV (GBE1) ⁶⁶ Glycogen synthesis ⁶⁶ glycolysis ¹ Glycolysis ⁶⁶ Glycolysis / Gluconeogenesis ³⁷ Glycolysis and Gluconeogenesis ¹ Glycolysis and gluconeogenesis (short map) ²² Lysosomal glycogen catabolism ⁶⁶ malate-aspartate shuttle ¹	12.38	DLD PC PDHA1 PDHX
4	Carbon metabolism ³⁷ Show member pathways 2-Oxocarboxylic acid metabolism ³⁷ Biosynthesis of amino acids ³⁷ formaldehyde oxidation ¹	12.1	DLD PC PDHA1 SUCLG1
5	Pyruvate metabolism and Citric Acid (TCA) cycle ⁶⁶ Show member pathways Citric acid cycle (TCA cycle) ⁶⁶ Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ⁶⁶ NAD phosphorylation and dephosphorylation ¹ Pyruvate metabolism ⁶⁶ Regulation of pyruvate dehydrogenase (PDH) complex ⁶⁶ TCA Cycle ¹	11.77	DLD PDHA1 PDHX PDP1 SUCLG1
6	Citrate cycle (TCA cycle) ³⁷ Show member pathways pyruvate decarboxylation to acetyl CoA ¹ superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle ¹ TCA cycle ¹ TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) ¹	11.64	DLD PC PDHA1 SUCLG1
7	Signaling by Retinoic Acid ⁶⁶ Show member pathways RA biosynthesis pathway ⁶⁶	11.45	DLD PDHA1 PDHX
8	Pyruvate metabolism ³⁷ Show member pathways methylglyoxal degradation I ¹ methylglyoxal degradation VI ¹	11.2	DLD PC PDHA1
9	Glyoxylate metabolism and glycine degradation ⁶⁶ Show member pathways D-Arginine and D-ornithine metabolism ³⁷ glycine biosynthesis ¹ glycine cleavage ¹ Glycine degradation ⁶⁶ lipoate biosynthesis and incorporation ¹ lipoate salvage ¹ Lipoic acid metabolism ³⁷	11.16	DLD PDHA1 PDHX
10	Amino Acid metabolism ¹	11.06	DLD LARS2 PC PDHA1 PDHX SUCLG1
11	Acetylcholine Synthesis ¹	10.28	CHAT PDHA1

Sources

GO Terms for Lactic Acidosis

Cellular components related to Lactic Acidosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial inner membrane	GO:0005743	9.8	MT-ATP6 MT-CO3 MT-CYB MT-ND1 MT-ND4 MT-ND5
2	mitochondrial matrix	GO:0005759	9.65	DLD ISCU LARS2 PC PDHA1 PDHX
3	respiratory chain	GO:0070469	9.62	MT-CYB MT-ND1 MT-ND4 MT-ND5
4	mitochondrion	GO:0005739	9.55	DLD ISCU LARS2 MT-CO3 MT-CYB MT-ND1
5	mitochondrial respiratory chain complex I	GO:0005747	9.54	MT-ND1 MT-ND4 MT-ND5
6	pyruvate dehydrogenase complex	GO:0045254	9.33	DLD PDHA1 PDHX

Biological processes related to Lactic Acidosis according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidation-reduction process	GO:0055114	9.99	DLD MT-CYB MT-ND1 MT-ND4 MT-ND5 PDHA1
2	metabolic process	GO:0008152	9.93	PC PDHA1 PDHX PNPLA8 SUCLG1
3	aging	GO:0007568	9.78	DLD MT-ATP6 MT-ND4 POLG
4	mitochondrial respiratory chain complex I assembly	GO:0032981	9.7	MT-ND1 MT-ND4 MT-ND5
5	tricarboxylic acid cycle	GO:0006099	9.58	DLD PDHA1 SUCLG1
6	mitochondrial electron transport, NADH to ubiquinone	GO:0006120	9.56	DLD MT-ND1 MT-ND4 MT-ND5
7	respiratory electron transport chain	GO:0022904	9.55	MT-CO3 MT-CYB
8	cellular nitrogen compound metabolic process	GO:0034641	9.54	DLD PDHA1 PDHX
9	response to hyperoxia	GO:0055093	9.5	MT-ATP6 MT-CYB POLG
10	ATP synthesis coupled electron transport	GO:0042773	9.49	MT-ND4 MT-ND5
11	acetyl-CoA biosynthetic process from pyruvate	GO:0006086	9.46	DLD PDHA1
12	electron transport coupled proton transport	GO:0015990	9.43	MT-CYB MT-ND4
13	mitochondrial acetyl-CoA biosynthetic process from pyruvate	GO:0061732	9.33	DLD PDHA1 PDHX
14	pyruvate metabolic process	GO:0006090	9.26	DLD PC PDHA1 PDHX
15	regulation of acetyl-CoA biosynthetic process from pyruvate	GO:0010510	8.92	DLD PDHA1 PDHX PDP1

Molecular functions related to Lactic Acidosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidoreductase activity	GO:0016491	9.73	DLD MT-CYB MT-ND1 MT-ND4 MT-ND5 PDHA1
2	electron transfer activity	GO:0009055	9.54	DLD MT-CO3 MT-CYB
3	NADH dehydrogenase (ubiquinone) activity	GO:0008137	9.5	MT-ND1 MT-ND4 MT-ND5
4	ligase activity	GO:0016874	9.46	LARS2 PC SUCLG1 YARS2
5	NADH dehydrogenase activity	GO:0003954	9.13	MT-ND1 MT-ND4 MT-ND5
6	pyruvate dehydrogenase (NAD+) activity	GO:0034604	8.8	DLD PDHA1 PDHX

Sources

Sources for Lactic Acidosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia